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med_alpaca_standardized_cluster_33_std

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3
6.34k
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2.69M
Please summerize the given abstract to a title
instruction
0
77,198
33
231,184
COVID-19 vaccines: Current evidence and considerations
output
1
77,198
33
231,185
The coronavirus disease 2019 (COVID-19) pandemic is a global crisis, with devastating health, business and social impacts. Vaccination is a safe, simple, and effective way of protecting a person against COVID-19. By the end of August 2021, only 24.6% of the world population has received two doses of a COVID-19 vaccine....
input
2
77,198
33
231,186
Please summerize the given abstract to a title
instruction
0
77,248
33
231,334
[Pharmacotherapeutic options for SARS-CoV-2 infection / COVID-19]
output
1
77,248
33
231,335
There is currently no proven effective therapy for COVID-19 Without wishing to be exhaustive, the drugs most studied in this regard are presented below Each of the listed therapeutic options is considered experimental at this stage However, given the severe public health implications of the epidemic and the potentially...
input
2
77,248
33
231,336
Please summerize the given abstract to a title
instruction
0
77,335
33
231,595
Hydroxychloroquine and chloroquine in COVID-19: should they be used as standard therapy?
output
1
77,335
33
231,596
The pandemic of the new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has urged the nations to an unprecedented world-wide reaction, including an accelerated exploration of therapeutic options. In the absence of a vaccine and specifically designed antivirals, the medical community ...
input
2
77,335
33
231,597
Please summerize the given abstract to a title
instruction
0
77,365
33
231,685
A Veterinary Vaccine for SARS-CoV-2: The First COVID-19 Vaccine for Animals
output
1
77,365
33
231,686
As coronaviruses have a wide range of host species, many animals harbor these pathogens, however only a handful of them become severely infected [...].
input
2
77,365
33
231,687
Please summerize the given abstract to a title
instruction
0
77,374
33
231,712
COVID-19: Vaccine Delivery System, Drug Repurposing and Application of Molecular Modeling Approach
output
1
77,374
33
231,713
The acute respiratory syndrome coronavirus (SARS-CoV-2) has spread across the world, resulting in a pandemic COVID-19 which is a human zoonotic disease that is caused by a novel coronavirus (CoV) strain thought to have originated in wild or captive bats in the initial COVID outbreak region. The global COVID-19 outbreak...
input
2
77,374
33
231,714
Please summerize the given abstract to a title
instruction
0
77,393
33
231,769
Therapy of Type 2 Diabetes in Patients with SARS-CoV-2 Infection
output
1
77,393
33
231,770
COVID-19 infection poses an important clinical therapeutic problem, especially in patients with coexistent diseases such as type 2 diabetes. Potential pathogenetic links between COVID-19 and diabetes include inflammation, effects on glucose homeostasis, haemoglobin deoxygenation, altered immune status and activation of...
input
2
77,393
33
231,771
Please summerize the given abstract to a title
instruction
0
77,403
33
231,799
Systemic Medications of Dermatological Importance in COVID-19
output
1
77,403
33
231,800
Early December 2019 witnessed an international outbreak of a novel coronavirus (COVID 19) designated severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) Since then, a number of therapeutic molecules have been explored to have potential efficacy against the SARS-Cov-2 per se or its sequelae There are no Food an...
input
2
77,403
33
231,801
Please summerize the given abstract to a title
instruction
0
77,468
33
231,994
Immunopathological Roles of Neutrophils in Virus Infection and COVID-19
output
1
77,468
33
231,995
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been spread around the world and is currently affecting global public health. Clinical evidence indicates that the elevated number of peripheral neutrophils and higher ratio of neutrophils-to-lymphoc...
input
2
77,468
33
231,996
Please summerize the given abstract to a title
instruction
0
77,544
33
232,222
Contribution of Nanotechnology in the Fight Against COVID-19
output
1
77,544
33
232,223
Coronavirus disease (COVID-19) is a respiratory infectious disease caused by a newly discovered virus strain, severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) This pandemic spread quickly across nations with a high mortality rate in immunocompromised patients This contagious disease posed a serious threat t...
input
2
77,544
33
232,224
Please summerize the given abstract to a title
instruction
0
77,684
33
232,642
Antiviral Potential of Nanoparticles-Can Nanoparticles Fight Against Coronaviruses?
output
1
77,684
33
232,643
Infectious diseases account for more than 20% of global mortality and viruses are responsible for about one-third of these deaths. Highly infectious viral diseases such as severe acute respiratory (SARS), Middle East respiratory syndrome (MERS) and coronavirus disease (COVID-19) are emerging more frequently and their w...
input
2
77,684
33
232,644
Please summerize the given abstract to a title
instruction
0
77,820
33
233,050
Vitamin D, zinc and glutamine: Synergistic action with OncoTherad immunomodulator in interferon signaling and COVID­19 (Review)
output
1
77,820
33
233,051
Coronavirus disease 2019 (COVID­19), caused by severe acute respiratory syndrome coronavirus 2 (SARS­CoV­2), was identified in December, 2019 in Wuhan, China. Since then, it has continued to spread rapidly in numerous countries, while the search for effective therapeutic options persists. Coronaviruses, including SARS­...
input
2
77,820
33
233,052
Please summerize the given abstract to a title
instruction
0
77,825
33
233,065
A review on Remdesivir: A broad-spectrum antiviral molecule for possible COVID-19 treatment.
output
1
77,825
33
233,066
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus strain and the causative agent of COVID-19 was identified to have emerged in Wuhan, China, in December 2019 [1]. This pandemic situation and magnitude of suffering has led to global effort to find out effective measures for discovery of n...
input
2
77,825
33
233,067
Please summerize the given abstract to a title
instruction
0
78,053
33
233,749
Delivery Routes for COVID-19 Vaccines
output
1
78,053
33
233,750
The novel coronavirus, SARS-CoV-2, which causes COVID-19, has resulted in a pandemic with millions of deaths. To eradicate SARS-CoV-2 and prevent further infections, many vaccine candidates have been developed. These vaccines include not only traditional subunit vaccines and attenuated or inactivated viral vaccines but...
input
2
78,053
33
233,751
Please summerize the given abstract to a title
instruction
0
78,105
33
233,905
Drug delivery systems as Immunomodulators for therapy of infectious disease: relevance to COVID-19
output
1
78,105
33
233,906
The emergence of SARS-CoV-2, and the ensuing global pandemic, has resulted in an unprecedented response to identify therapies that can limit uncontrolled inflammation observed in patients with moderate to severe COVID-19. The immune pathology behind COVID-19 is complex and involves the activation and interaction of mul...
input
2
78,105
33
233,907
Please summerize the given abstract to a title
instruction
0
78,131
33
233,983
Management of sars-cov-2 (Covid-19) infection with special focus on use of hydroxychloroquine and lopinavir/ritonavir
output
1
78,131
33
233,984
Editor’s comment-A The covid-19 pandemic is the greatest challenge for the current generation of physicians, scientists and health administrators B Strict use of PPE, face masks, isolation and quarantine are the most effective methods of prevention of this infection C The immunomodulator hydroxychloroquine is approved ...
input
2
78,131
33
233,985
Please summerize the given abstract to a title
instruction
0
78,190
33
234,160
[Umifenovir and coronavirus infections: a review of research results and clinical practice]
output
1
78,190
33
234,161
Coronaviruses are known to cause acute respiratory infections. Antiviral therapy, including for COVID-19, is based on clinical practice, experimental data and trial results. The purpose of this review is to: provide and systematize actual preclinical data, clinical trials results and clinical practice for antiviral age...
input
2
78,190
33
234,162
Please summerize the given abstract to a title
instruction
0
78,265
33
234,385
Homeopathic Treatment for COVID-19-Related Symptoms: A Case Series
output
1
78,265
33
234,386
BACKGROUND: Severe acute respiratory syndrome due to coronavirus 2 (SARS CoV-2) is a novel infectious disease, which has quickly developed into a pandemic. The spectrum of COVID-19 symptoms is broad, ranging from a mild, self-limiting respiratory tract illness to severe progressive pneumonia, multi-organ failure and po...
input
2
78,265
33
234,387
Please summerize the given abstract to a title
instruction
0
78,288
33
234,454
Open Questions for Harnessing Autophagy-Modulating Drugs in the SARS-CoV-2 War
output
1
78,288
33
234,455
At a time when the world faces an emotional breakdown, crushing our dreams if not taking our lives, we realize that together we must fight the war against the COVID-19 outbreak even if almost the majority of the scientific community finds itself confined to home. Every day, like everyone else, we, scientists, listen to...
input
2
78,288
33
234,456
Please summerize the given abstract to a title
instruction
0
78,298
33
234,484
COVID-19 occurring during Natalizumab treatment: a case report in a patient with extended interval dosing approach
output
1
78,298
33
234,485
BACKGROUND: The novel Coronavirus SARS-CoV-2, which was identified after a recent outbreak in Wuhan, China, in December 2019, has generated a global pandemic impacting over 200 countries around the world. Recent reports suggest that ACE2, which is the target protein to invade the host, has a ubiquitous presence in huma...
input
2
78,298
33
234,486
Please summerize the given abstract to a title
instruction
0
78,377
33
234,721
Interleukin‐6 Receptor Antagonist Therapy to Treat SARS‐CoV‐2 Driven Inflammatory Syndrome in a Renal Transplant Recipient
output
1
78,377
33
234,722
Coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a pandemic that is evolving rapidly at present with unprecedented global health and societal implications. Herein, we report a case of successful treatment of SARS‐CoV‐2 induced inflammatory syndrome by utiliza...
input
2
78,377
33
234,723
Please summerize the given abstract to a title
instruction
0
78,453
33
234,949
Arginine depletion as a therapeutic approach for patients with COVID-19
output
1
78,453
33
234,950
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a source of significant morbidity and death worldwide, and effective treatments are urgently needed. Clinical trials have focused largely on direct antiviral therapies or on immunomodulation in patients with severe manifes...
input
2
78,453
33
234,951
Please summerize the given abstract to a title
instruction
0
78,584
33
235,342
Therapeutic Options for Treatment of COVID-19: A Review from Repur-posed Drugs to New Drug Targets.
output
1
78,584
33
235,343
A new virus pandemic, COVID-19, has instigated substantial damage to human wellness in terms of death and ailment, economic compromises along with restriction of daily routine life. There is a profound increase in the number of victims and causalities day by day. Thus far, there is no available treatment and vaccinatio...
input
2
78,584
33
235,344
Please summerize the given abstract to a title
instruction
0
78,596
33
235,378
Ivermectin the Promising Drug to Stave off the COVID-19 Crisis: A Review
output
1
78,596
33
235,379
The Coronavirus disease 2019 (COVID-19) outbreak, forcing us to face unprecedented moments in the world The huge devastating impact of the world due to the covid-19 attack causes the brink of no return However, there is no proven and specific treatment for Covid -19 Very few medications have received Emergency Use of A...
input
2
78,596
33
235,380
Please summerize the given abstract to a title
instruction
0
78,701
33
235,693
Metabolic Reprogramming in COVID-19
output
1
78,701
33
235,694
Plenty of research has revealed virus induced alternations in metabolic pathways, which is known as metabolic reprogramming. Studies focusing on COVID-19 have uncovered significant changes in metabolism, resulting in the perspective that COVID-19 is a metabolic disease. Reprogramming of amino acid, glucose, cholesterol...
input
2
78,701
33
235,695
Please summerize the given abstract to a title
instruction
0
78,719
33
235,747
Role of Polypeptide Inflammatory Biomarkers in the Diagnosis and Monitoring of COVID-19
output
1
78,719
33
235,748
The COVID-19 (coronavirus disease 2019) pandemic that took over the world in December 2019 has had everlasting devastating impacts on the lives of people globally. It manifests a huge symptom spectrum ranging from asymptomatic to critically ill patients with an unpredictable outcome. Timely diagnosis and assessment of ...
input
2
78,719
33
235,749
Please summerize the given abstract to a title
instruction
0
78,750
33
235,840
COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications
output
1
78,750
33
235,841
COVID-19 is a severe infectious disease that has claimed >150,000 lives and infected millions in the United States thus far, especially the elderly population. Emerging evidence has shown the virus to cause hemorrhagic and immunologic responses, which impact all organs, including lungs, kidneys, and the brain, as well ...
input
2
78,750
33
235,842
Please summerize the given abstract to a title
instruction
0
78,783
33
235,939
Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China
output
1
78,783
33
235,940
A novel coronavirus (2019-nCoV) originating in Wuhan, China presents a potential respiratory viral pandemic to the world population. Current efforts are focused on containment and quarantine of infected individuals. Ultimately, the outbreak could be controlled with a protective vaccine to prevent 2019-nCoV infection. W...
input
2
78,783
33
235,941
Please summerize the given abstract to a title
instruction
0
78,823
33
236,059
Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective Role
output
1
78,823
33
236,060
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections present with increased disease severity and poor clinical outcomes in diabetic patients compared with their nondiabetic counterparts. Diabetes/hyperglycemia-triggered endothelial dysfunction and hyperactive inflammatory and immune responses are cor...
input
2
78,823
33
236,061
Please summerize the given abstract to a title
instruction
0
79,000
33
236,590
Lithium and coronaviral infections. A scoping review.
output
1
79,000
33
236,591
The current rapid spread of the novel coronavirus (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) calls for a rapid response from the research community. Lithium is widely used to treat bipolar disorder, but has been shown to exhibit antiviral activity. This brief review took a systematic approach to identify ...
input
2
79,000
33
236,592
Please summerize the given abstract to a title
instruction
0
79,148
33
237,034
Management of SARS-CoV-2 Infection: Key Focus in Macrolides Efficacy for COVID-19
output
1
79,148
33
237,035
Macrolides (e g , erythromycin, fidaxomicin, clarithromycin, and azithromycin) are a class of bacteriostatic antibiotics commonly employed in medicine against various gram-positive and atypical bacterial species mostly related to respiratory tract infections, besides they possess anti-inflammatory and immunomodulatory ...
input
2
79,148
33
237,036
Please summerize the given abstract to a title
instruction
0
79,407
33
237,811
Gene therapies and COVID-19 vaccines: a necessary discussion in relation with viral vector-based approaches
output
1
79,407
33
237,812
The COVID-19 pandemic is adding an unanticipated concern for those affected by genetic diseases. Most of the new treatment achievements for these patients are made possible as a result of advances in viral-based products. Among them, adenoviruses (AdV) and especially adeno-associated viruses (AAV) are important players...
input
2
79,407
33
237,813
Please summerize the given abstract to a title
instruction
0
79,451
33
237,943
Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections
output
1
79,451
33
237,944
The recent Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak poses a serious threat to public health. Here, we summarize recent advances in identifying human neutralizing monoclonal antibodies (mAbs) against MERS-CoV, describe their mechanisms of action, and analyze their potential for treatment of MERS-...
input
2
79,451
33
237,945
Please summerize the given abstract to a title
instruction
0
79,470
33
238,000
Evolutionary artificial intelligence based peptide discoveries for effective Covid-19 therapeutics
output
1
79,470
33
238,001
An epidemic caused by COVID-19 in China turned into pandemic within a short duration affecting countries worldwide. Researchers and companies around the world are working on all the possible strategies to develop a curative or preventive strategy for the same, which includes vaccine development, drug repurposing, plasm...
input
2
79,470
33
238,002
Please summerize the given abstract to a title
instruction
0
79,541
33
238,213
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