input stringlengths 1 5.61k | output stringlengths 14 122k |
|---|---|
### Instruction:
Please answer the letter of option truthfully
### Response:
C
### Response:
| Q:Over 1 year, a study is conducted to assess the antileukemic activity of a new tyrosine kinase inhibitor in patients with chronic myeloid leukemia in blast crisis. All patients enrolled in the study are informed that they would be treated with the tyrosine kinase inhibitor. They are assigned to successive dose cohort... |
### Instruction:
Answer this question truthfully
### Response:
The formula to calculate the attributable risk percent in the exposed (ARPexposed) is: ARPexposed = 100 x [(RR-1)/RR]. In epidemiology, the attributable risk percent (ARP) is a measure of the proportion of disease incidence in an exposed population that ca... | What is the formula to calculate the attributable risk percent in the exposed (ARPexposed)? |
### Instruction:
Answer this question truthfully
### Response:
The formula used to calculate bioavailability using graphs of plasma concentration vs time for nonintravenous and intravenous administration is F = (AUC oral x dose IV) / (AUC IV x dose oral).
### Response:
| What is the formula used to calculate bioavailability using graphs of plasma concentration vs time for nonintravenous and intravenous administration? |
### Instruction:
Answer this question truthfully
### Response:
Tisagenlecleucel is a CAR T-cell Therapy that is indicated for relapsed B-cell acute lymphoblastic leukemia (B-ALL) by targeting the CD19 antigen.
### Response:
| What is the indication for Tisagenlecleucel, a CAR T-cell Therapy, and which antigen does it target? |
### Instruction:
Answer this question truthfully
### Response:
The main objectives of Phase II in clinical trials are to assess optimal dosing, treatment efficacy, and adverse effects. During this phase, aspects of the treatment such as safety, efficacy, and dosage are typically evaluated.
### Response:
| What are the main objectives of Phase II in clinical trials and what aspects of the treatment are typically evaluated during this phase? |
### Instruction:
Answer this question truthfully
### Response:
The purpose of Phase III in clinical trials is to confirm the safety and efficacy of a treatment under investigation. During this phase, a large number of patients are randomly assigned either to the treatment being studied or to the best available treatme... | What is the purpose of Phase III in clinical trials and how are patients typically assigned to different treatment groups during this phase? |
### Instruction:
Answer this question truthfully
### Response:
To calculate a 95% confidence interval when given a sample mean and standard error, you can use the formula CI = X ± Z(SE), where CI is the confidence interval, X is the sample mean, SE is the standard error, and Z is the critical value from the standard n... | How do you calculate a 95% confidence interval when given a sample mean and standard error? |
### Instruction:
Answer this question truthfully
### Response:
The rates of survival for neoplastic meningitis varies depending on the source of primary tumor, but generally median survival rate without treatment is limited to 1 to 2 months. With treatment, this could extend to 2 to 5 months for breast cancer, 3 to 6 ... | What to expect if I have Neoplastic meningitis (Outlook/Prognosis)? |
### Instruction:
Answer this question truthfully
### Response:
People who are at risk of head and neck cancers ―particularly those who use tobacco ―should talk with their doctor about ways that they may be able to reduce their risk. They should also discuss with their doctor how often to have checkups. In addition, on... | How can I reduce my risk of developing head and neck cancers? |
### Instruction:
Answer this question truthfully
### Response:
Current literature suggests that in patients with refractory chronic rhinosinusitis endoscopic sinus surgery(ESS) is superior to continued medical therapy in terms of symptom relief, quality of life and cost effectiveness with reported incremental cost eff... | How cost-effective is therapy for treating rhinosinusitis? |
### Instruction:
Answer this question truthfully
### Response:
Recent advances in the understanding of the pathogenesis of mantle cell lymphoma have led to the development of targeted therapies which have shown potential promise as effective therapeutic approaches in the future.. In addition to the ongoing assessment ... | What are the potential future or experimental treatments for mantle cell lymphoma? |
### Instruction:
Answer this question truthfully
### Response:
WikiDoc Resources for Omegaven Articles Most recent articles on Omegaven Most cited articles on Omegaven Review articles on Omegaven Articles on Omegaven in N Eng J Med, Lancet, BMJ Media Powerpoint slides on Omegaven Images of Omegaven Photos of Omegaven ... | What is Omegaven and what is an overview of it? |
### Instruction:
Answer this question truthfully
### Response:
Stem cell transplant may be offered for CML in the chronic phase. It is sometimes used as a primary treatment option for younger people who have an HLA -matched donor. It is a treatment option for some people who do not achieve a complete response or devel... | What medical therapy is used to treat chronic myelogenous leukemia? |
: | What medical therapy is utilized for HIV and AIDS? |
### Instruction:
Answer this question truthfully
### Response:
The mainstay of treatment for mantle cell lymphoma is chemotherapy. However, immunotherapy, radioimmunotherapy, targeted therapy using newer biologic agents and stem cell transplantation are also used along with chemotherapy to treat the disease. Mantle ce... | Can you provide a summary of mantle cell lymphoma? |
### Instruction:
Answer this question truthfully
### Response:
In 1882, A.C. Doyle reported on the efficacy of arsenic in acute promyelocytic leukemia. In 1957, Leif Hillestad described acute promyelocytic leukemia as a distinct clinical condition for the first time. He noted the syndrome of low fibrinogen levels, fi... | What is the historical context surrounding acute promyelocytic leukemia? |
### Instruction:
Answer this question truthfully
### Response:
The objective of this trial is to study the effect of dalcetrapib on cardiovascular mortality and morbidity in patients with recent acute coronary syndrome in patients on statin therapy.
### Response:
| What are the results or findings of the Dal-OUTCOMES trial? |
### Instruction:
Answer this question truthfully
### Response:
Class IIa " 5. In intermediate-risk adults, risk-enhancing factors favor initiation or intensification of statin therapy (Level of Evidence B-R)".'' 6. In intermediate-risk or selected borderline-risk adults, if the decision about statin use remains uncert... | What is the purpose of the ACC: AHA guideline for primary prevention of hypercholesterolemia? |
### Instruction:
Answer this question truthfully
### Response:
FDA declined approval of rivaroxaban for ACS in May 2012 , citing: High incomplete follow up (12%) Vital status missing (9%) Uncounted deaths Different rates of outcomes between first and second halves of the trial are concerning for informative censoring ... | Can you provide an instance of ATLAS that was mentioned by JC? |
### Instruction:
Answer this question truthfully
### Response:
The table below summarizes the different standard treatment options according to the TNM criteria for non-small cell lung cancer. To have a detailed information on the sequential management please click on each TNM stage in the table.
Standard Treatment O... | What is the approach to managing non-small cell lung cancer? |
### Instruction:
Answer this question truthfully
### Response:
Rifabutin is as effective for tuberculosis treatment as rifampin, but has much less effect on drugs metabolized through the CYP3A system. However, rifabutin is either not available or is very expensive in countries with high rates of HIV-related tubercu... | What is the meaning of drug interaction? |
### Instruction:
Answer this question truthfully
### Response:
Using either technetium 99 mTc pertechnetate or I123 Radionuclide scan is contraindicated during pregnancy Thyroid scintigraphy is useful to determine the functional status of a nodule. It is specifically indicated in patients with thyroid nodule and a low... | What imaging findings are there besides the thyroid nodule? |
### Instruction:
Answer this question truthfully
### Response:
E7070 E7389 EBV ecchymosis echocardiography ecteinascidin 743 ectocervical edatrexate edotecarin edrecolomab EF5 efaproxiral effector cell efficacy eflornithine EGb761 EGFR EKB-569 electroacupuncture electrodesiccation electrolarynx electroporation therapy... | What are some terms related to oncology that can be listed? |
### Instruction:
Answer this question truthfully
### Response:
WikiDoc Resources for Timeline of peptic ulcer disease and Helicobacter pylori Articles Most recent articles on Timeline of peptic ulcer disease and Helicobacter pylori Most cited articles on Timeline of peptic ulcer disease and Helicobacter pylori Review ... | What is the timeline for the development of peptic ulcer disease in relation to Helicobacter pylori? |
### Instruction:
Answer this question truthfully
### Response:
Selected patients with high-risk disease have an increased occurance of relapse during delayed intensification chemotherapy This includes patients with severe hypodiploid acute lymphoblastic luekemia, those with the KMT2A rearrangement, and infants with ac... | What is the appropriate medical treatment for acute lymphoblastic leukemia? |
### Instruction:
Answer this question truthfully
### Response:
The selection of a TKI for initial treatment of CML in chronic is determined by the following: Prognostic score Side effect profiles Comorbid illnesses Cost
The following suggestions for treatment of chronic phase CML are influenced by the CML risk score (... | What medical treatment is available for chronic myelogenous leukemia? |
### Instruction:
Answer this question truthfully
### Response:
WikiDoc Resources for Treatment of Crohn's disease Articles Most recent articles on Treatment of Crohn's disease Most cited articles on Treatment of Crohn's disease Review articles on Treatment of Crohn's disease Articles on Treatment of Crohn's disease in... | What is the recommended treatment for Crohn's disease? |
### Instruction:
Answer this question truthfully
### Response:
The precise incidence of POEMS syndrome is difficult to determine and we have no well established data to quote. The median age at presentation has been 51 years with the majority of the patients comprising of males. A median survival of 165 months has als... | Can you provide a summary of the POEMS syndrome? |
### Instruction:
Answer this question truthfully
### Response:
Incidence and severity of objectively documented deep vein thrombosis (DVT) and/or pulmonary embolism (PE) Time Frame: Duration of intervention per patient (24 months) Designated as safety issue: Yes
Incidence and severity of signs and symptoms associated ... | What is the level of safety and effectiveness of using a D-Dimer-guided strategy to extend secondary prophylaxis of venous thromboembolism, as tested in a prospective and randomized management trial? |
### Instruction:
Answer this question truthfully
### Response:
Study Description Study Type Interventional Study Phase Phase III Study Design Allocation Randomized Endpoint Safety/Efficacy Study Interventional Model Parallel Assignment Masking Double Blind Study Details Primary Purpose Treatment Condition Coronary Hea... | What are the outcomes of the Dal-OUTCOMES Trial? |
### Instruction:
Answer this question truthfully
### Response:
Mesalazine File:Mesalazine structure.svg Clinical data Routes of administration oral rectal ATC code A07EC02 (WHO) Pharmacokinetic data Bioavailability orally: 20-30% absorbed rectally: 10-35% Metabolism Rapidly & extensively metabolised intestinal mucosal... | What exactly is Mesalazine and can you provide a summary of it? |
### Instruction:
Answer this question truthfully
### Response:
The main aims of therapy are prolonging survival, improving quality of life and avoiding treatment-induced toxicity. Given that treatment is palliative, patients should be given treatment holidays in order to reduce drug-induced toxicity. HER2 overexpressi... | What is the chemotherapy treatment for breast cancer? |
### Instruction:
Answer this question truthfully
### Response:
Pegylated Interferon Alfa-2B (Peg Intron) plus Ribavirin versus Standard Interferon Alfa-2B (Intron A) plus Ribavirin:
This was a randomized, phase 3, open-label, parallel group study. Four hundred sixteen treatment naïve patients were assigned to 1.5 mcg/... | What medical treatment is used for individuals co-infected with HIV and hepatitis C? |
### Instruction:
Answer this question truthfully
### Response:
James Cerhan and colleagues, try to determine genetic susceptibility that exists for this cancer by meta-analysis of three genome-wide association studies (GWAS). For this, a total of 3,857 cases and 7,666 controls were analyzed. This study is divided int... | What are the potential treatments that are still in development or being investigated for diffuse large B cell lymphoma in the future? |
### Instruction:
Answer this question truthfully
### Response:
A pivotal study published in 1993 compared CHOP to several other chemotherapy regimens (e.g. m-BACOD, ProMACE-CytaBOM, MACOP-B). CHOP emerged as the regimen with the least toxicity but similar efficacy.
### Response:
| What is the explanation for the relationship between CHOP and history? |
### Instruction:
Answer this question truthfully
### Response:
Prior to the introduction of readily available diagnostics and targeted therapeutics, the prognosis of acute promyelocytic leukemia was previously very poor, especially in the early phase of the disease. The poor prognosis was due to high bleeding risk a... | What are the natural history, prognosis, and potential complications associated with acute promyelocytic leukemia? |
### Instruction:
Answer this question truthfully
### Response:
Tests and treatment go through four different phases of clinical trail to test the benefits of it. The four phases of treatment are as follows.
Phase 1 trial
It aims to find out the best dose of a new drug with the lowest side effects
Phase 2 trial
Asses ... | What therapies are currently under investigation for the treatment of liposarcoma in the future? |
### Instruction:
Answer this question truthfully
### Response:
The majority of patients with symptomatic, first-episode genital HSV-2 infection subsequently experience recurrent episodes of genital lesions. All patients who develop recurrent genital herpes require antimicrobial therapy using either suppressive therap... | What is the antiviral treatment for herpes simplex virus that causes recurrent genital herpes? |
### Instruction:
Answer this question truthfully
### Response:
The treatment of HIV associated nephropathy (HIVAN) includes: combined antiretroviral therapy (cART), renin–angiotensin–aldosterone system (RAAS) blockade, corticosteroids and renal replacement with dialysis.
Kidney transplantation is increasing in HIV -p... | Can you provide an overview of nephropathy associated with HIV? |
### Instruction:
Answer this question truthfully
### Response:
A 53-week, randomized, double-blind, placebo-controlled Phase II/III trial demonstrated that Elaprase provides clinically important benefits to Hunter syndrome patients. The primary efficacy endpoint of the trial was a composite analysis of changes from ba... | What is the medical treatment for Hunter Syndrome? |
### Instruction:
Answer this question truthfully
### Response:
Support groups and organizations are available to help individuals learn more about vitiligo, understand treatment options, and find support from other individuals with vitiligo.
Vitiligo Support International is the largest vitiligo organization in the wo... | What is vitiligo and what are the important facts to know about this condition? |
### Instruction:
Answer this question truthfully
### Response:
Those with ALK positivity have a better prognosis. ALK-negative anaplastic large cell lymphomas represent other T-cell lymphomas in a final common pathway of disease progression. Overall better prognosis than other aggressive lymphomas. ALK-positive anapl... | What is the natural history, prognosis, and potential complications associated with anaplastic large cell lymphoma? |
### Instruction:
Answer this question truthfully
### Response:
According to the Myeloma Mayo Stratification of Myeloma and Risk-Adapted Therapy (Myeloma M-SMART), medical therapy for transplant-eligible patients is individualized based on the patient risk. The algorithm is shown below:
According to the Myeloma Mayo ... | What is the medical therapy for multiple myeloma? |
### Instruction:
Answer this question truthfully
### Response:
Once the suspicious lesion is evaluated, the medical therapy is based upon the low-risk and high-risk basal cell carcinoma patients.
The table below summarizes the characteristics in low-risk and high-risk lesions .
Area H = “mask areas” of face (central f... | What is the medical treatment for basal cell carcinoma? |
### Instruction:
Answer this question truthfully
### Response:
Rhabdomyosarcoma treatment include combination of surgery, radiotherapy, and chemotherapy. Rhabdomyosarcoma treatments depends on staging classification and risk stratification. For more information click here. Rhabdomyosarcoma chemotherapy depends on pat... | What medical treatment is recommended for Rhabdomyosarcoma? |
### Instruction:
Answer this question truthfully
### Response:
Much clinical use of statins reflects marketting rather than the practice of evidenced based medicine. In Quebec by 2003 Atorvastatin had 44% of the market share while simvastatin had 29.9%. In contrast up to the previous year simvastatin had 133,341 of RC... | What information is currently available regarding statins? |
### Instruction:
Answer this question truthfully
### Response:
Despite the FDA issuing an approvable letter in February 2006 for the obesity indication and a non-approvable letter for smoking cessation, the drug did not enter the market in the United States in 2006. The French pharma firm Sanofi-Aventis disclosed that... | What is the reason for the approval of Rimonabant? |
### Instruction:
Please answer with one of the option in the bracket
### Response:
C: 400 / (400+50)
### Response:
| Q:A novel PET radiotracer is being evaluated for its ability to aid in the diagnosis of Alzheimer’s disease (AD). The study decides to use a sample size of 1,000 patients, and half of the patients enrolled have AD. In the group of patients with AD, 400 are found positive on the novel type of PET imaging examination. In... |
### Instruction:
Please answer with one of the option in the bracket
### Response:
B: Phase III
### Response:
| Q:An experimental new drug (SD27C) is being studied. This novel drug delivers insulin via the intranasal route. Consent is obtained from participants who are diabetic and are taking insulin as their current treatment regimen to participate in a clinical trial. 500 patients consent and are divided into 2 groups, and a d... |
### Instruction:
Please answer with one of the option in the bracket
### Response:
B: 53%
### Response:
| Q:A pharmaceutical company has created an experimental medication, Drug Z, for patients with relapsing-remitting multiple sclerosis. Drug Z has been deemed to be safe in rats and is nearly ready for human trials. Before initiating a Phase I clinical trial, the company would like to study the medication’s pharmacokineti... |
### Instruction:
Please answer with one of the option in the bracket
### Response:
B: Level 2
### Response:
| Q:A research team develops a new monoclonal antibody checkpoint inhibitor for advanced melanoma that has shown promise in animal studies as well as high efficacy and low toxicity in early phase human clinical trials. The research team would now like to compare this drug to existing standard of care immunotherapy for ad... |
### Instruction:
Please answer with one of the option in the bracket
### Response:
A: 450 / (450 + 50)
### Response:
| Q:You conduct a medical research study to determine the screening efficacy of a novel serum marker for colon cancer. The study is divided into 2 subsets. In the first, there are 500 patients with colon cancer, of which 450 are found positive for the novel serum marker. In the second arm, there are 500 patients who do n... |
### Instruction:
Please answer with one of the option in the bracket
### Response:
C: Yes, the research team has seen an improvement in sensitivity of almost 7% according to the new results listed.
### Response:
| Q:A research team is working on a new assay meant to increase the sensitivity of testing in cervical cancer. Current sensitivity is listed at 77%. If this research team’s latest work culminates in the following results (listed in the table), has the sensitivity improved, and, if so, then by what percentage?
Research te... |
### Instruction:
Please answer with one of the option in the bracket
### Response:
D: 49%
### Response:
| Q:A randomized controlled trial was initiated to evaluate a novel DPP-4 inhibitor for blood glucose management in diabetic patients. The study used a commonly prescribed sulfonylurea as the standard of care treatment. 2,000 patients were enrolled in the study with 1,000 patients in each arm. One of the primary outcomes... |
### Instruction:
Please answer with one of the option in the bracket
### Response:
A: Lead time bias; Pygmalion effect
### Response:
| Q:Two studies are reviewed for submission to an oncology journal. In Sudy A, a novel MRI technology is evaluated as a screening tool for ovarian cancer. The authors find that the mean survival time is 4 years in the control group and 10 years in the MRI-screened group. In Study B, cognitive behavioral therapy (CBT) and... |
### Instruction:
Please answer with one of the option in the bracket
### Response:
C: The range of outcome values resulting from the trial has a 95% probability of encompassing the true value.
### Response:
| Q:A randomized control double-blind study is conducted on the efficacy of 2 sulfonylureas. The study concluded that medication 1 was more efficacious in lowering fasting blood glucose than medication 2 (p ≤ 0.05; 95% CI: 14 [10-21]). Which of the following is true regarding a 95% confidence interval (CI)??
{'A': 'It r... |
### Instruction:
Please answer with one of the option in the bracket
### Response:
C: Randomization
### Response:
| Q:A group of investigators seeks to compare the non-inferiority of a new angiotensin receptor blocker, salisartan, with losartan for reduction of blood pressure. 2,000 patients newly diagnosed with hypertension are recruited for the trial; the first 1,000 recruited patients are administered losartan, and the other half... |
### Instruction:
Please answer with one of the option in the bracket
### Response:
D: To reduce selection bias
### Response:
| Q:Please refer to the summary above to answer this question
In the study, all participants who were enrolled and randomly assigned to treatment with pulmharkimab were analyzed in the pulmharkimab group regardless of medication nonadherence or refusal of allocated treatment. A medical student reading the abstract is con... |
### Instruction:
Please answer with one of the option in the bracket
### Response:
B: Latency period
### Response:
| Q:A study seeks to investigate the therapeutic efficacy of treating asymptomatic subclinical hypothyroidism in preventing symptoms of hypothyroidism. The investigators found 300 asymptomatic patients with subclinical hypothyroidism, defined as serum thyroid-stimulating hormone (TSH) of 5 to 10 μU/mL with normal serum t... |
### Instruction:
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
### Response:
This is no advice
### Response:
| The efficacy and safety of everolimus plus trastuzumab and paclitaxel as first-line treatment for HER2+ advanced breast cancer in the Asian subset was consistent with that reported previously in the overall population. |
### Instruction:
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
### Response:
This is no advice
### Response:
| After standard neoadjuvant chemotherapy containing anthracycline, taxane, or both, the addition of adjuvant capecitabine therapy was safe and effective in prolonging disease-free survival and overall survival among patients with HER2-negative breast cancer who had residual invasive disease on pathological testing. |
### Instruction:
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
### Response:
This is no advice
### Response:
| Among patients with HER2-negative metastatic breast cancer and a germline BRCA mutation, olaparib monotherapy provided a significant benefit over standard therapy; median progression-free survival was 2.8 months longer and the risk of disease progression or death was 42% lower with olaparib monotherapy than with stand... |
### Instruction:
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
### Response:
This is no advice
### Response:
| In summary, RTX therapy induces resolution of pulmonary granulomatous inflammation in GPA following prolonged B cell depletion. |
### Instruction:
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
### Response:
This is no advice
### Response:
| This retrospective study investigated the correlation between liver tests abnormalities and treatment outcomes in patients with unresectable advanced or metastatic soft tissue sarcomas (STS) treated with trabectedin 1.5 mg/m(2) once every 3 weeks at three reference centers in Italy. |
### Instruction:
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
### Response:
This is no advice
### Response:
| Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. |
### Instruction:
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
### Response:
This is no advice
### Response:
| This study aimed to explore the combined association between AKT serine/threonine kinase 1 (AKT1) polymorphisms and congenital heart disease (CHD) risk, meanwhile, the role of AKT1 single polymorphism on CHD was also analyzed.In the first, AKT1 polymorphisms were genotyped in 130 CHD patients and 145 healthy people wit... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Treatment Outcomes of IL-17 Inhibitors in Hidradenitis Suppurativa: A Systematic Review.
### Response:
| The IL-17 pathway is a potential therapeutic target shown to be implicated in hidradenitis suppurativa (HS), however, it remains unclear whether evidence from mechanistic studies may translate into clinical practice. This systematic review summarizes available treatment outcomes of IL-17 inhibitors in patients with HS.... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Cervical Cancer Screening with HPV Testing: Updates on the Recommendation.
### Response:
| The present update is a reassessment of the 2018 'Guidelines for HPV-DNA Testing for Cervical Cancer Screening in Brazil' (Zeferino et al.)9, according to the changes observed in new international guidelines and knowledge updates. The most relevant and recent guidelines were assessed. Questions regarding the clinical p... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Screening for Dental Infections Achieves 6-Fold Reduction in Dental Emergencies During Induction Chemotherapy for Acute Myeloid Leukemia
### Response:
| PURPOSE: Patients with newly diagnosed acute myeloid leukemia (AML) are at risk of infection, including odontogenic infections, during induction chemotherapy. It is unknown whether clinical dental screening to diagnose and treat odontogenic disease in these patients can reduce the incidence of dental emergencies. METHO... |
### Instruction:
Please summerize the given abstract to a title
### Response:
False sense of safety by daily QTc interval monitoring during methadone IVPCA titration in a patient with chronic pain.
### Response:
| It has been proposed that some deaths attributed to methadone are related to prolongation of the QTc interval; however, there are no clear recommendations on electrocardiogram (ECG) monitoring in patients undergoing intravenous methadone infusion. This is a report on a patient receiving methadone intravenous patient-co... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Effect of hepatitis C antiviral therapy on oral lichen planus and hyposalivation in inmates
### Response:
| BACKGROUND: Oral lichen planus (OLP) and hyposalivation have been reported as extrahepatic manifestations of hepatitis C virus (HCV) infection. Our study evaluated the effect of direct antiviral agents (DAAs) on OLP and hyposalivation in convicts with chronic hepatitis C, examining patients before, during and after the... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Principal stratum strategy: Potential role in drug development.
### Response:
| A randomized trial allows estimation of the causal effect of an intervention compared to a control in the overall population and in subpopulations defined by baseline characteristics. Often, however, clinical questions also arise regarding the treatment effect in subpopulations of patients, which would experience clini... |
### Instruction:
Please summerize the given abstract to a title
### Response:
SER-109, an Investigational Microbiome Drug to Reduce Recurrence After Clostridioides difficile Infection: Lessons Learned From a Phase 2 Trial
### Response:
| BACKGROUND: Recurrent Clostridioides difficile infection (rCDI) is associated with loss of microbial diversity and microbe-derived secondary bile acids, which inhibit C. difficile germination and growth. SER-109, an investigational microbiome drug of donor-derived, purified spores, reduced recurrence in a dose-ranging,... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Cost-effectiveness of postmastectomy hypofractionated radiation therapy vs conventional fractionated radiation therapy for high-risk breast cancer
### Response:
| BACKGROUND: The phase 3 NCT00793962 trial demonstrated that postmastectomy hypofractionated radiation therapy (HFRT) was noninferior to conventional fractionated radiation therapy (CFRT) in patients with high-risk breast cancer. This study assessed the cost-effectiveness of postmastectomy HFRT vs CFRT based on the NCT0... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Skin Tests in The Work-Up of Cutaneous Adverse Drug Reactions: A Review and Update.
### Response:
| Skin tests, including patch tests (PTs), prick tests and intradermal tests (IDTs), are useful to identify the culprit(s) of a cutaneous adverse drug reaction (CADR), and to determine (a) safer alternative drug(s). PTs have a low sensitivity but are valuable to investigate maculopapular exanthema (MPE), as well as sever... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Chronic Cognitive Impairment in AQP4+ NMOSD With Improvement in Cognition on Eculizumab: A Report of Two Cases
### Response:
| Cognitive impairment may be associated with aquaporin-4 antibody positive (AQP4+) NMOSD, particularly where there is prominent cerebral, corpus callosum, or thalamic involvement. It is unclear to what extent this phenomenon may be treatable after months to years. We describe two cases of AQP4+ NMOSD with cognitive impa... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Childhood-onset systemic lupus erythematosus and immune thrombocytopenia: Prevalence and risk factors
### Response:
| BACKGROUND: There are few studies examining the prevalence and clinical risk factors for subsequent systemic lupus erythematosus (SLE) development after long-term follow-up in childhood immune thrombocytopenia (ITP). The aims of this study were to evaluate the prevalence and risk factors for subsequent SLE development ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Experience with tacrolimus in children with steroid-resistant nephrotic syndrome
### Response:
| Children with steroid-resistant nephrotic syndrome (SRNS) are at risk of developing renal failure. We report here the results of a single-center retrospective observational study of the remission rate in pediatric patients with SNRS receiving tacrolimus. Serial renal biopsies from children on tacrolimus therapy were ev... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Predictive Performance of Serum S100B Versus LDH in Melanoma Patients: A Systematic Review and Meta-Analysis
### Response:
| BACKGROUND: Currently, no consensus on the use of blood tests for monitoring disease recurrence in patients with resected melanoma exists. The only meta-analysis conducted in 2008 found that elevated serum S100B levels were associated with significantly worse survival in melanoma patients. Serum LDH is an established p... |
### Instruction:
Please summerize the given abstract to a title
### Response:
429 Incidence and management of adverse events among COVID-19 vaccination receipts with Brugada syndrome. Results from a multicentre-prospective European registry
### Response:
| AIMS: Patients with Brugada syndrome have an increased risk of life-threatening arrhythmias when experience fever. Therefore, a prompt treatment of non-steroidal anti-inflammatory drugs (NSAI) is suggested in these patients. COVID-19 vaccination can be associated with fever in about 20% of patients. The aim of the stud... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Influenza and Other Prophylactic Vaccination Coverage in Polish Adult Patients Undergoing Allergen Immunotherapy—A Survey Study among Patients and Physicians
### Response:
| Vaccines against infectious diseases may raise safety concerns in patients undergoing allergen immunotherapy (AIT). The objective of our study was to investigate influenza vaccine and other selected prophylactic vaccines coverage in patients treated with AIT and the attitude of physicians towards vaccinations in this g... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Cancer patient survival can be parametrized to improve trial precision and reveal time-dependent therapeutic effects
### Response:
| Individual participant data (IPD) from oncology clinical trials is invaluable for identifying factors that influence trial success and failure, improving trial design and interpretation, and comparing pre-clinical studies to clinical outcomes. However, the IPD used to generate published survival curves are not generall... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Monitoring tumor growth rate to predict immune checkpoint inhibitors' treatment outcome in advanced NSCLC
### Response:
| Introduction: Radiological response assessment to immune checkpoint inhibitor is challenging due to atypical pattern of response and commonly used RECIST 1.1 criteria do not take into account the kinetics of tumor behavior. Our study aimed at evaluating the tumor growth rate (TGR) in addition to RECIST 1.1 criteria to ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Qualitative analysis of gynecologic oncology patients’ experience with treatment holidays
### Response:
| OBJECTIVE: Patients with advanced or recurrent gynecologic malignancies occasionally take breaks from systemic treatment colloquially referred to as “treatment holidays” or “chemotherapy holidays.” There are no data from the patient perspective that help describe this experience. METHODS: Patients with recurrent or adv... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Sequencing Therapies for Metastatic Renal Cell Carcinoma
### Response:
| In an era of several therapeutic options available, optimal treatment sequencing is crucial to providing patients the most effective therapy and promoting quality of life. In clear cell renal cell carcinoma, a combination approach with an immunotherapy backbone, such as nivolumab/ipilimumab or axitinib/pembrolizumab, h... |
### Instruction:
Please summerize the given abstract to a title
### Response:
A Preterm Case of Cow’s Milk Allergy Presenting with Recurrent Ascites Treated with Donor Breast Milk
### Response:
| We report a case of a preterm infant who developed cow’s milk allergy. This male infant presented with recurrent ascites and was successfully treated with donated breast milk. He was born at 24 weeks’ gestation with a birthweight of 506 g. From day 20, infant formula, soy protein-based formula, and casein-hydrolyzed fo... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Repeated Multimodality Ablative Therapies for Oligorecurrent Pulmonary Metastatic Disease.
### Response:
| Stereotactic body radiotherapy (SBRT) and percutaneous thermal ablation (TA) are alternatives to surgery for the management of pulmonary oligometastases. In this collaborative work, we retrospectively analyzed patients who had undergone iterative focal ablative treatments of pulmonary oligometastases. We hypothesized t... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Comparative efficacy of placebos in short-term antidepressant trials for major depression: a secondary meta-analysis of placebo-controlled trials
### Response:
| BACKGROUND: The issue of unblinded outcome-assessors and patients has repeatedly been stressed as a flaw in allegedly double-blind antidepressant trials. Unblinding bias can for example result from a drug's marked side effects. If such unblinding bias is present for a given drug, then it might be expected that the plac... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Rapidly progressive cognitive decline associated with teprotumumab in thyroid eye disease
### Response:
| Teprotumumab (Tepezza), an insulin-like growth factor type 1 receptor antagonist, was approved for treatment of thyroid eye disease in 2020. Teprotumumab is administered intravenously every 3 weeks for a total of eight doses. Common side effects include nausea, diarrhoea, muscle spasms, hearing impairment, dysgeusia, h... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Report from the CVOT Summit 2020: new cardiovascular and renal outcomes
### Response:
| The 6th Cardiovascular Outcome Trial (CVOT) Summit "Cardiovascular and Renal Outcomes 2020" was the first to be held virtually on October 29-30, 2020. As in previous years, this summit served as reference meeting for in-depth discussions on the topic of recently completed and presented major outcome trials. This year, ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Clozapine resistant schizophrenia: Newer avenues of management
### Response:
| About 40%-70% of the patients with treatment-resistant schizophrenia have a poor response to adequate treatment with clozapine. The impact of clozapine-resistant schizophrenia (CRS) is even greater than that of treatment resistance in terms of severe and persistent symptoms, relapses and hospitalizations, poorer qualit... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Differences in Use of Aggressive Therapy for Localized Prostate Cancer in New York City
### Response:
| BACKGROUND: Socioeconomic factors may impact how a patient is treated for prostate cancer (CaP). Our objective was to determine if county of residence or neighborhood socioeconomic characteristics were associated with treatment for CaP in New York City (NYC). MATERIALS AND METHODS: We used the NYSPACED database to iden... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Illustrative Cases from the Pathfinder Clinical Trials of Patients with Hemophilia A Treated with Turoctocog Alfa Pegol (N8-GP)
### Response:
| PURPOSE: To illustrate the benefits of the extended half-life (EHL) recombinant factor VIII product N8-GP (Esperoct(®), turoctocog alfa pegol) by describing individual cases of patients with severe hemophilia A treated with N8-GP in the pathfinder clinical trial program. PATIENTS AND METHODS: This manuscript presents s... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Homologous Recombination Deficiency in Patients With Pancreatic Ductal Adenocarcinoma and Response to Chemotherapy.
### Response:
| PURPOSE Mutations or copy number abnormalities of genes involved in homologous recombination (HR) occur in pancreatic ductal adenocarcinoma (PDAC). DNA-based measures of HR deficiency (HRD) have been developed and may help identify tumors with better response to DNA-damaging agents. This study aimed to describe the HR ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
A prognostic nomogram for colorectal cancer liver metastases after percutaneous thermal ablation.
### Response:
| PURPOSE To assess the efficacy of percutaneous thermal ablation in treating colorectal cancer liver metastases (CRCLM), and to propose a prognostic nomogram for overall survival (OS). MATERIALS AND METHODS Seventy-one patients with CRCLM undergoing thermal ablation at our institute from 2009 to 2013 were identified and... |
### Instruction:
Please summerize the given abstract to a title
### Response:
A Rare Case of Large-Vessel Vasculitis following Checkpoint Inhibitor Therapy and Pegfilgrastim
### Response:
| Checkpoint inhibitors (CPIs) and pegfilgrastim, a long-acting growth factor agent, are vital components of current cancer treatments. Immune-related adverse events (irAEs) such as colitis and pneumonitis are well-established toxicities associated with CPI therapy. However, large-vessel vasculitis secondary to CPI utili... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Utility of remission criteria for the renal prognosis of IgA nephropathy
### Response:
| BACKGROUND: Novel criteria for the remission of Immunoglobulin A nephropathy (IgAN) based on an opinion survey of Japanese nephrologists and literature review were proposed in 2013. This single-center, longitudinal retrospective cohort study was conducted to validate this criteria. METHODS: Present study included the I... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Safety and family satisfaction of a home-delivered chemotherapy program for children with cancer
### Response:
| BACKGROUND: Home chemotherapy programs for children with cancer are safe and feasible, and their impact on the quality of life has been reported in different countries. A home chemotherapy program was implemented between 2011 and 2019 in an Italian region. This pilot study investigates its safety and feasibility, along... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Metastatic prostate cancer presenting as incidental pelvic lymphadenopathy – a report of three cases with literature review
### Response:
| The presence of metastatic lymph nodes is a poor prognostic factor in patients with prostate cancer. Currently, there is no national prostate cancer screening program through prostate-specific antigen testing and the benefits of initiating such a scheme have not yet been proven. However, an informed choice program is i... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Skin Cancer Incidence and Mortality in Spain: A Systematic Review and Meta-Analysis.
### Response:
| INTRODUCTION AND OBJECTIVES The aim of this systematic review was to describe the incidence and mortality of basal cell carcinoma, squamous cell carcinoma, melanoma, and Merkel cell carcinoma in Spain. MATERIAL AND METHODS We performed a search of the MEDLINE and Embase databases and reviewed articles from the Spanish ... |
End of preview. Expand in Data Studio
- Downloads last month
- 2