Add pipeline tag and improve model card
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by nielsr HF Staff - opened
README.md
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<h1 align="center">
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TD3B: Transition-Directed Discrete Diffusion for Allosteric Binder Generation
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</h1>
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<div align="center">
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<a href="https://arxiv.org/abs/2605.09810"><img src="https://img.shields.io/badge/Arxiv-2605.09810-red?style=for-the-badge&logo=Arxiv" alt="arXiv"/></a>
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</div>
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TD3B is a sequence-based generative framework that designs peptide binders with specified agonist or antagonist behavior. It combines a Direction Oracle, a soft binding-affinity gate, and amortized fine-tuning of a pre-trained discrete diffusion model (MDLM).
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## Installation
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@inproceedings{
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cao2026td3b,
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title={TD3B: Transition-Directed Discrete Diffusion for Allosteric Binder Generation},
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author={
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booktitle={Forty-third International Conference on Machine Learning},
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year={2026},
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url={https://
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}
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```
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---
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pipeline_tag: text-generation
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---
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<h1 align="center">
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TD3B: Transition-Directed Discrete Diffusion for Allosteric Binder Generation
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</h1>
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<div align="center Murphy">
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<a href="https://huggingface.co/papers/2605.09810"><img src="https://img.shields.io/badge/Paper-2605.09810-red?style=for-the-badge" alt="Paper"/></a>
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<a href="https://arxiv.org/abs/2605.09810"><img src="https://img.shields.io/badge/Arxiv-2605.09810-red?style=for-the-badge&logo=Arxiv" alt="arXiv"/></a>
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</div>
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TD3B is a sequence-based generative framework that designs peptide binders with specified agonist or antagonist behavior. It combines a target-aware Direction Oracle, a soft binding-affinity gate, and amortized fine-tuning of a pre-trained discrete diffusion model (MDLM).
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The model was presented in [TD3B: Transition-Directed Discrete Diffusion for Allosteric Binder Generation](https://huggingface.co/papers/2605.09810).
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## Installation
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@inproceedings{
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cao2026td3b,
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title={TD3B: Transition-Directed Discrete Diffusion for Allosteric Binder Generation},
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author={Hanqun Cao and Aastha Pal and Sophia Tang and Yinuo Zhang and Jingjie Zhang and Pheng Ann Heng and Pranam Chatterjee},
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booktitle={Forty-third International Conference on Machine Learning},
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year={2026},
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url={https://huggingface.co/papers/2605.09810}
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}
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```
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