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# Oxford Protein Informatics Group (OPIG)

**Computational research at the interface of protein science, immunology, and drug discovery**

We are a research group led by [Charlotte Deane](https://www.stats.ox.ac.uk/~deane/) in the [Department of Statistics, University of Oxford](https://www.stats.ox.ac.uk/). Our work combines machine learning, structural biology, and cheminformatics to tackle fundamental problems in protein structure, antibody engineering, and small molecule drug design.

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## Research Areas

**Immunoinformatics** — Antibody and T-cell receptor structure prediction, developability assessment, repertoire analysis, and antigen binding.

**Protein Structure** — Structure prediction, conformational dynamics, protein folding, and language models for genomic and proteomic sequences.

**Small Molecules** — Structure-based drug design, molecular docking, generative models for drug-like molecules, and binding affinity prediction.

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## Key Open-Source Tools & Databases

| Tool | Description |
|------|-------------|
| [**SAbDab**](http://opig.stats.ox.ac.uk/webapps/newsabdab/sabdab) | Structural Antibody Database — all antibody structures from the PDB, updated weekly |
| [**OAS**](http://opig.stats.ox.ac.uk/webapps/oas) | Observed Antibody Space — billions of antibody sequences from immune repertoire sequencing studies |
| [**STCRDab**](http://opig.stats.ox.ac.uk/webapps/stcrdab) | Structural T-Cell Receptor Database |
| [**CoV-AbDab**](http://opig.stats.ox.ac.uk/webapps/coronavirus) | Coronavirus Antibody Database — antibodies targeting SARS-CoV-2 and related coronaviruses |
| [**AbLang**](https://github.com/oxpig/AbLang) | Antibody language model for sequence infilling and representation |
| [**ANARCI**](https://github.com/oxpig/anarci) | Antibody and TCR sequence numbering and annotation |
| [**ABlooper**](https://github.com/oxpig/ABlooper) | Fast, accurate CDR loop structure prediction |
| [**Paragraph**](https://github.com/oxpig/Paragraph) | Graph neural network-based antibody paratope prediction |
| [**MolSnapper**](https://github.com/oxpig/MolSnapper) | Conditioning diffusion models for structure-based drug design |
| [**STRIFE**](https://github.com/oxpig/STRIFE) | Fragment elaboration using pharmacophoric constraints |
| [**CaLM**](https://github.com/oxpig/CaLM) | Codon-aware language model for protein engineering |

All of our open-source code lives at **[github.com/oxpig](https://github.com/oxpig)**.

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## Get Involved

- 🌐 **Website**: [opig.stats.ox.ac.uk](https://opig.stats.ox.ac.uk)
- 📝 **Blog**: [blopig.com/blog](https://blopig.com/blog) — tutorials, methods explainers, and research updates
- 🦋 **Bluesky**: [@opig.stats.ox.ac.uk](https://bsky.app/profile/opig.stats.ox.ac.uk)
- 🐦 **X/Twitter**: [@OPIGlets](https://x.com/OPIGlets)
- 💼 **LinkedIn**: [Oxford Protein Informatics Group](https://www.linkedin.com/company/oxford-protein-informatics-group-opig/)

Interested in a DPhil or postdoc? See our [current research](https://opig.stats.ox.ac.uk/research) and [get in touch](https://opig.stats.ox.ac.uk/contact).