TASK_DATA = { "known_signal_easy": { "reports": [ { "report_id": "PV-EASY-001", "patient_age": 59, "patient_sex": "female", "drugs": ["Lisinopril 20mg"], "suspect_drug": "Lisinopril", "reaction": "Persistent dry cough", "onset_days": 11, "severity": "mild", "outcome": "not_recovered", "similar_reports_last_30d": 1264, } ], "ground_truth": { "classification": "known_side_effect", "suspect_drug": "Lisinopril", "severity_assessment": "mild", "recommended_action": "log_and_monitor", }, "drug_interaction_db": { "Lisinopril": { "known_reactions": ["dry cough", "hyperkalemia", "angioedema"], "class_note": "ACE inhibitors frequently cause persistent non-productive cough.", } }, }, "cluster_signal_medium": { "reports": [ { "report_id": "PV-MED-001", "patient_age": 44, "patient_sex": "female", "drugs": ["Cardiovexa"], "suspect_drug": "Cardiovexa", "reaction": "symptomatic bradycardia with dizziness", "onset_days": 9, "severity": "moderate", "outcome": "not_recovered", "similar_reports_last_30d": 5, }, { "report_id": "PV-MED-002", "patient_age": 69, "patient_sex": "male", "drugs": ["Cardiovexa"], "suspect_drug": "Cardiovexa", "reaction": "heart rate 32 with near-syncope", "onset_days": 13, "severity": "severe", "outcome": "not_recovered", "similar_reports_last_30d": 5, }, { "report_id": "PV-MED-003", "patient_age": 57, "patient_sex": "female", "drugs": ["Cardiovexa"], "suspect_drug": "Cardiovexa", "reaction": "fatigue and sinus bradycardia", "onset_days": 7, "severity": "moderate", "outcome": "not_recovered", "similar_reports_last_30d": 5, }, { "report_id": "PV-MED-004", "patient_age": 63, "patient_sex": "male", "drugs": ["Cardiovexa"], "suspect_drug": "Cardiovexa", "reaction": "bradyarrhythmia requiring ER evaluation", "onset_days": 11, "severity": "severe", "outcome": "not_recovered", "similar_reports_last_30d": 5, }, ], "ground_truth": { "classification": "new_signal", "suspect_drug": "Cardiovexa", "severity_assessment": "severe", "recommended_action": "escalate", }, "drug_interaction_db": { "Cardiovexa": { "known_reactions": ["headache", "fatigue"], "approval_date": "5 months ago", "label_note": "No labeled conduction or rhythm adverse effects.", } }, }, "confounded_hard": { "reports": [ { "report_id": "PV-HARD-001", "patient_age": 63, "patient_sex": "male", "drugs": [ "Tacrolimus", "Prednisone", "Amlodipine", "Magnesium oxide", "Voriconazole", "Trimethoprim-sulfamethoxazole", ], "suspect_drug": "Trimethoprim-sulfamethoxazole", "reaction": "Acute kidney injury with tacrolimus trough 4x baseline", "onset_days": 6, "severity": "critical", "outcome": "not_recovered", "similar_reports_last_30d": 1, } ], "ground_truth": { "classification": "new_signal", "suspect_drug": "Tacrolimus+Voriconazole", "severity_assessment": "critical", "recommended_action": "escalate", }, "drug_interaction_db": { "Voriconazole": { "strong_metabolic_inhibitor": True, "interacts_with": ["Tacrolimus", "Cyclosporine"], "interaction_note": "Markedly increases tacrolimus exposure; dose reduction and level monitoring required.", }, "Tacrolimus": { "narrow_therapeutic_index": True, "known_reactions": ["nephrotoxicity", "tremor"], "requires_level_monitoring": True, }, }, }, }