data/raw/knowledge/drug_knowledge.json

{
  "drug_classes": {
    "warfarin_like": "anticoagulant",
    "benzodiazepine_like": "sedative",
    "metformin_like": "glucose_lowering",
    "statin_like": "lipid_lowering",
    "ace_inhibitor_like": "antihypertensive",
    "nsaid_like": "analgesic",
    "opioid_like": "analgesic",
    "ssri_like": "antidepressant",
    "ppi_like": "gastro",
    "beta_blocker_like": "antihypertensive"
  },
  "example_top_pairs": [
    [
      "warfarin_like",
      "nsaid_like"
    ],
    [
      "benzodiazepine_like",
      "opioid_like"
    ]
  ],
  "side_effect_tags": {
    "benzodiazepine_like": [
      "sedation",
      "falls"
    ],
    "opioid_like": [
      "respiratory_depression",
      "sedation"
    ],
    "warfarin_like": [
      "bleeding"
    ],
    "nsaid_like": [
      "bleeding",
      "renal_injury"
    ]
  },
  "substitutions": {
    "nsaid_like": [
      "acetaminophen_like",
      "topical_nsaid_like"
    ],
    "benzodiazepine_like": [
      "non_benzo_sleep_support"
    ],
    "opioid_like": [
      "non_opioid_analgesic"
    ]
  },
  "taper_required": {
    "warfarin_like": false,
    "benzodiazepine_like": true,
    "metformin_like": false,
    "statin_like": false,
    "ace_inhibitor_like": false,
    "nsaid_like": false,
    "opioid_like": true,
    "ssri_like": false,
    "ppi_like": false,
    "beta_blocker_like": false
  },
  "renal_flags": {
    "warfarin_like": false,
    "benzodiazepine_like": false,
    "metformin_like": true,
    "statin_like": false,
    "ace_inhibitor_like": false,
    "nsaid_like": true,
    "opioid_like": false,
    "ssri_like": false,
    "ppi_like": false,
    "beta_blocker_like": false
  },
  "hepatic_flags": {
    "warfarin_like": false,
    "benzodiazepine_like": true,
    "metformin_like": false,
    "statin_like": false,
    "ace_inhibitor_like": false,
    "nsaid_like": false,
    "opioid_like": true,
    "ssri_like": false,
    "ppi_like": false,
    "beta_blocker_like": false
  }
}