Repaying your debts can be a burden, especially when the world is recovering from a pandemic that has caused significant economic challenges. Many people don’t know where to start, and their debts accumulate to hard-to-pay levels. However, you must pay what you owe, for instance, by acquiring debt from Priority Plus Financial and other reputable lenders. Nonetheless, you must also understand the best debt management, primarily after such a finance-draining season. This article explains these steps in detail for better comprehension.
Avoid Borrowing if Possible
The first and best way to manage your debts is to avoid them if you can. One mistake many make is acquiring loans just because they qualify for one or a lender avails it. Getting a debt without apparent reasons jeopardizes your finances, knowing the lender will require you to pay back their money.
You must be strategic in how you borrow. It’s recommendable to have a clear plan on how to spend the cash you borrow, but only if you have an unavoidable need for a loan. Primarily, ensure you use the money you borrow to generate more income to help you cover your debt. Alternatively, you can get a debt to cover urgent expenses, such as a stinging hospital bill.
Review Your Budget
How you spend your money can contribute to better debt management or financial crisis, whether at home or in your business. A lack of a detailed budget can lead to over-borrowing, meaning you get a bigger debt than you require. On the flip side, it can also lead you to borrow less than you need, making it necessary to consider getting another loan to cover the balance.
You must be strategic about your budget and know your required amount. If your savings cover these expenses, you can return to the first tip and avoid acquiring a needless loan. Alternatively, your budget will guide you on the amount to borrow if the need arises.
Consider Debt Consolidation
Debt consolidation loans have gained popularity in the current world as more people realize their benefits. Debt consolidation refers to the financing you acquire to facilitate your other debts. The main idea behind this funding is to refund your personal and credit card unpaid amounts using a home mortgage option with a higher cost-efficiency.
Understand the Borrowing Terms
Different lenders have varying terms and requirements. Unfortunately, many borrowers just read the agreement but don’t understand what it entails. You must be keen on all the laid-out details when getting a debt, before taking the plunge. You can consult with a financier who understands these terms and conditions. Interest rates are among the subjects that confuse many borrowers, and they end up paying a lot when clearing their debts. Ask questions for clarity wherever you need help understanding.
Debt management is a phenomenon confusing many people globally. Fortunately, the points above expound further on this subject to paint a clearer image. The information is just the tip of the iceberg. There are many details about debt management from different sources, making it vital to research more.


So, in a nutshell, ‘crisis’
does not equal ‘opportunity’. This was a myth that’s been propagated over the years due to a misinterpretation of the Chinese characters. danger opportunity â. crisis
The third, and fatal, misapprehension is the author’s definition of jÄ« as “opportunity.” While it is true that wÄ.ijÄ« does indeed mean “crisis” and that the wÄ.i syllable of wÄ.ijÄ« does convey the notion of “danger,” the jÄ« syllable of wÄ.ijÄ« most definitely does not signify “opportunity.” Webster’s Ninth New Collegiate Dictionary defines “opportunity” as:
a favorable juncture of circumstances; a good chance for advancement or progress.
While that may be what our Pollyanaish advocates of “crisis” as “danger” plus “opportunity” desire jÄ« to signify, it means something altogether different.
The jÄ« of wÄ.ijÄ«, in fact, means something like “incipient moment; crucial point (when something begins or changes).” Thus, a wÄ.ijÄ« is indeed a genuine crisis, a dangerous moment, a time when things start to go awry.


The EB-5 Regional Center Program, which was suspended since June 30, 2021, will restart. The U.S. Congress included in the government spending bill the authorization and reform of the EB-5 Regional Center Program, referred to as the
“EB-5 Reform and Integrity Act”.
After nearly 8.5 months in lapse the EB-5 Regional Center Program may be authorized until September 30, 2027 – with the following significant changes, among others:
InvestmentAmounts Investment amounts would increase to $800,000 in Targeted Employment Areas (TEA’s), geographic areas designated by the appropriate government authority as priority high-unemployment areas, and $1,050,000 in non-TEAs with investment amounts adjusted for inflation every five years starting January 1, 2027. Concurrent Filing of EB-5 Petition andApplication to Adjust Status Investorsin the United States will be able to file their EB-5 petitions along with their application for a “conditional” green card, which adjusts status from a “non-immigrant” to a conditional permanent resident if a visa is available. concurrently “Grandfathering” Existing Investors If Congress fails to authorize the EB-5 Regional Center Program after its expiration September 30, 2027, DHS shall continue to process petitions filed on or before September 30, 2026 – preventing a repeat of what has happened to existing EB-5 regional center investors since June 30, 2021. Visa set-asides The approximately 10,000 EB-5 visas available every year (including dependents) will include set-asides for the following categories: Rural Projects (20%) – Priority Processing Rural areas are defined as areas outside a Metropolitan Statistical area, or within the outer boundary of any city or town with a population of 20,000 or more. Distressed Urban Area Projects (10%) Distressed Urban Areas are defined as areas where average unemployment rate for the census tract(s) is 150% of the national average unemployment rate Infrastructure Projects (2%) Infrastructure Projects are defined as a “capital investment project” administered by a “governmental entity” that serves as the “job-creating entity” which receives capital from EB-5 investors, and contracts with a regional center. Unused visas “carry over” in the same category in the immediately following year Unused visas in any category made generally available for any project, in the year immediately following the “carry-over” year
Pending EB-5 petitions submitted until June 30, 2021, will not be subject to the new rules or higher investment amount and adjudication of these petitions and adjustment of status applications or consular processing will resume upon the effective date of the legislation.
Written by Chris Costa, Senior Associate at Drummond Advisors, and Matheus Etrusco, Associate at Drummond Advisors


In a 2021 State of Hispanic Homeownership report published by the National Association of Hispanic Real Estate Professionals (NAHREP), Latinos are 81% more likely to be denied mortgage financing for a conventional home loan than white applicants. Median white households possess more than five times the wealth of median Latino households, boosting their options of having on-hand all-cash offers or easily qualifying for pre-approval in the current hot real estate market because of intergenerational wealth disparities. These all play a crucial role in the current homeownership gap.
Achieving the dream of homeownership is a significant accomplishment for most everyone; however, the barriers faced by Black and Latino homebuyers are greater, especially first-time homebuyers, still hampered by racial discrimination, income inequality, and the lasting effects of predatory lending and redlining.
Bias in home appraisals for those two groups of color results in lower rates of homeownership. In a 2021 study by Freddie Mac, Blacks and Hispanics are more likely to experience undervalued homes in neighborhoods where they are a majority compared to majority-white communities. Data extrapolated from more than twelve million appraisals conducted between January 2015 to December 2020 showed that 15.4% of Latino census tracts were appraised at values lower than the contract price compared with 7.4% of homes in white census tracts.
Those rejected for a conventional home loan often consider mortgages insured by the Federal Housing Administration (FHA) as an alternative. Latinos are twice as likely to opt for this loan than their non-Hispanic White counterparts. These loans appear to be a great option, especially for those with non-traditional credit or lower credit scores. However accessible, they come with a higher cost that includes mortgage insurance or MI, added to the monthly payment for the life of the loan when the borrower opts for the lowest down payment option.
Over the next two decades, Latinos are projected to make up 70% of homeownership growth. Credit unions that serve this growing demographic would be well-positioned with expanded approval guidelines that take much more into account than conventional credit underwriting criteria to meet this demand.
About Inclusiv/Mortgage
Expanding access to homeownership is a key component of Inclusiv's mission of financial inclusion. Launched in 2005, Inclusiv's mortgage initiative, Inclusiv/Mortgage established a secondary market for member credit unions’ mortgage loans to low- and moderate-income members. Over the years demand has grown significantly with a portfolio now comprised of $26 million in affordable home mortgages originated by more than thirty Community Development Credit Unions (CDCUs) nationwide (as of July 2022.)
Historically, lenders have limited financing to no more than 80% of the home’s loan-to-value due to the inherent risk of extending credit to Individual Taxpayer Identification Number (ITIN) holders and a significant percentage of Latino homebuyers. Despite the overall positive performance of ITIN loans, the secondary market has been slow to adjust risk exposure accordingly. Inclusiv/Mortgage recently began offering approved sellers an outlet for up to 90% loan-to-values on ITIN mortgage loans.


Enterprise hardware and software assets come with default settings for easy use and quick deployment. However, these default configurations introduce security risks to the organization’s network. For example, open ports, unnecessary applications, and services provide hackers with potential attack vectors.
Creating configuration standards from scratch is a tough sell for most organizations. So instead, they rely on publicly available third-party configuration baselines to secure their assets. The two most common baselines include Security Technical Implementation Guide (STIG) and Center for Internet Security (CIS) Benchmarks.
This guide is dedicated to helping you choose the best configuration standards for your organization.
Our Recommendation = Use CIS Benchmarks
For most organizations, it makes sense to implement CIS Benchmarks over the STIG framework. The benchmarks cover all common assets, including network devices, mobile devices, operating systems, applications, and cloud hosting services. Whatever the asset, you are guaranteed the industry’s best configuration settings for hardening your systems.
CIS Benchmarks also tie into major regulatory frameworks such as PCI DSS, ISO 27000, HIPPA, SWIFT, and NIST CSF. For example, PCI DSS standards recommend using benchmarking tools. Given the CIS Benchmarks are consensus-driven and internationally recognized, it makes sense to implement them as a first step toward mandatory regulatory compliance.
Furthermore, CIS Benchmarks are more widely used than the STIG Framework. The Center for Internet Security comprises a consortium of subject matter experts drawn from the private sector, manufacturing, vendors, government, research, and academia. Therefore, there is plenty of supporting material to complement the CIS Benchmarks.
By contrast, the STIG Framework was developed by the Defense Information Systems Agency (DISA). As a result, additional supporting information, research, resources, and tools may be more challenging to come by. This limitation is a natural consequence of the limited scope of parties involved in developing the framework, particularly compared to the CIS.
Finally, the STIG Framework is designed primarily for the Department of Defense (DoD) and its affiliates. The Framework is still freely available to the private sector. However, you can tell from the documentation and jargon that it is geared toward U.S Government use. The terminology may be difficult and borderline frustrating to translate for private businesses that don’t require STIG compliance.
The CIS caters to a broader target audience, including government institutions, private businesses, and organizations of all sizes and industries. The terminology is simple and universal and easy to cross-reference with other known standards and regulatory frameworks.
When To Use STIGs Instead
Again, the STIGs were developed for the Department of Defense. So STIG is the defacto configuration framework for DoD agencies. So, it makes sense for a Federal IT professional within the DoD to comply with STIGs over CIS Benchmarks.
However, all organizations that are part of the Department of Defense Information Networks (DoDIN) are legally and contractually required to comply with STIGs. This category includes contractors that connect to DoD systems and networks. So, a defense contractor may want to focus on meeting STIG compliance before deploying the CIS Benchmarks.
STIG compliance is also a requirement for software and hardware operating on DoD systems and networks. So, vendors whose products are meant for use in the Defense Information Networks should focus on complying with STIG cybersecurity requirements.
Finally, organizations that require high-level security configurations may opt for STIGs. These requirements are more stringent than CIS Benchmarks. However, it makes sense since they are developed for the Department of Defense, which works with highly sensitive and classified data. STIGs are also updated every 90 days, so you’re always guaranteed the most current standards.
Pricing – Is STIG or CIS the Better Deal?
We won’t attempt to compare the cost of implementing STIG vs. CIS Benchmarks, because the cost of deploying these baseline controls varies widely between organizations. Instead, we’ll compare the price of the documentation and supporting tools.
The Security Technical Implementation Guides (STIGs) are free to download. By default, the guidelines are available in XML format. You can visit the DoD Cyber Exchange website to download the relevant STIGs for your device and operating system.
The CIS Benchmarks are also free to download in PDF format. However, you’ll need to sign up for an account to download the benchmarks. Signing up for the account is free.
STIG vs. CIS – File Formats
The file format may not be a deal-breaker for most people. However, it’s still worth investigating. STIGs are available in XML format, precisely the XCCDF format. Unfortunately, the format is notoriously difficult to read. But you can overcome this problem by parsing the document with an XCCDF viewer.
The CIS Benchmarks are available in PDF format. It’s a more accessible choice for most people. You can also convert the benchmarks into XCCDF files with the paid version of the CIS-CAT. We go into more details about the CIS-CAT in a different section of this post.
SITG vs. CIS – Commercial Adoption Winner = CIS
Both STIG and CIS see extensive commercial adoption. However, STIGs are often used by government agencies and private sector businesses that work within the national supply chain. Still, STIGs are publicly available for commercial adoption.
It’s no surprise that the CIS Benchmarks enjoy broader adoption in the private sector. The benchmarks are heavily peer-reviewed and consensus-driven. STIGs tend to use government-mandated language, which might be unpopular for organizations that aren’t required to comply with the standards.
STIG vs. CIS – Ease of Implementation Winner = CIS
Both STIGs and CIS Benchmarks are relatively easy to implement. This ease is primarily thanks to the documents’ clear structure.
For instance, STIG categorizes its controls based on risk level. There are three main categories, including:
CAT 1 – This is the most severe risk level. The controls in this category help neutralize direct threats to system availability and data integrity. CAT 2 – The vulnerabilities are less severe than CAT 1 but still open to exploitation. There is a lower risk of compromised system availability and data integrity. However, these vulnerabilities are serious and should be addressed quickly. CAT 3 – These vulnerabilities do not pose an immediate risk of system failure or cybersecurity incidents. However, the vulnerabilities may still affect an organization’s overall security posture.
Similarly, the CIS Benchmarks categorize recommendations based on the potential impact of the recommendation. These categories are called profiles and include:
Level 1 Profile – This level focuses on surface-level recommendations to remediate the most common cybersecurity vulnerabilities. The recommendations in this profile can be implemented quickly and with little or no disruption to normal operations. Level 2 Profiles – This level features more complex recommendations that deal with high-level threats. These recommendations benefit organizations that prioritize cybersecurity or are accountable to cybersecurity regulations and compliance. However, implementing recommendations in this category may cause some disruption to normal operations.
In short, STIG and CIS standards offer a simple and straightforward framework for configuring networks. However, the CIS uses more concise language and might be easier to implement.
STIG vs. CIS – Implementation and Compliance Tools
Security control frameworks often feature hundreds of recommendations. The extensive documentation helps provide organizations with actionable recommendations for system hardening. However, manually applying each recommendation is tedious, if not impossible. Implementation tools help to automate the process and reduce incidents of human error.
STIG Implementation and Tools Winner = CIS
STIG offers handy tools to help you automate recommendations, implementation, and compliance.
The most popular tool is the STIG Viewer. You can download the JAR file for free at the DoD Public Cyber Exchange website. The tool allows you to view the STIGs XML file in OVAL or XCCDF format, depending on your use case.
Additionally, the STIG Viewer allows you to create a STIG checklist. Simply import the STIG file you downloaded to the STIG Viewer. Then, select the relevant STIG, and the tool will create a checklist for you to follow during implementation.
It’s worth noting that the STIG Viewer is designed to simplify the recommendations. The tool doesn’t automate implementation or compliance. It also doesn’t scan your system for compliance.
Still, it’s a valuable tool for managing compliance. It provides all STIGs in a central place. You can also select specific rules for your organization and get in-depth information about each control.
For example, each selected STIG rule explains why the item is essential. It also guides how to check for compliance with the specific STIG rule. Finally, the STIG Viewer provides specific action steps for complying with the selected rules.
SCAP Compliance Checker (SCC)
The Secure Content Automation Protocol (SCAP) checker is a helpful tool for assessing compliance. It’s more robust than the STIG Viewer and, therefore, worth deploying. It’s available for free at the DoD Cyber Exchange Website.
The SCAP Checker displays all available STIG benchmarks when you launch the tool. Then, you can select specific criteria and scan a local or remote system. You’ll receive checklist files with the scan results, which you can import into the STIG Viewer.
Again, this tool doesn’t automatically remediate non-compliant items. However, it’s still helpful in determining your compliance posture. You can then use the STIG Viewer for the action steps to remediate non-compliant items.
Overall, STIG offers limited tools to automate compliance. You’ll have to rely on third-party tools such as PowerSTIG to automate the implementation. Specifically, PowerSTIG is an open-source project that lets you create Desired State Configurations based on STIG guidelines.
CIS Implementation and Compliance Tools
The Center for Internet Security offers a tool similar to the SCAP Compliance Checker. It’s known as the CIS-CAT Benchmark Assessment Tool and is slightly more robust than the STIG tool.
For example, you can track CIS compliance over time, assign user roles, and collaborate across teams. You can also upload supporting documentation and monitor compliance with additional benchmarks such as PCI, HIPPA, and FISMA. This is much more than you get with the SCAP SCC.
The version of the tool is the CIS-CAT Lite. It is available for free download. This version lets you scan CIS Benchmarks compliance for Google Chrome, Ubuntu, and Windows 10. You’ll receive a compliance score from 1-100. You’ll also receive specific remediation steps to ensure compliance.
The CIS-CAT Pro version offers more features. For instance, you can scan for more than 80 CIS Benchmarks, unlike the Light version, which is limited to selected benchmarks. This version also supports more operating systems and applications. In addition, you can customize the benchmark contents and view assessment results directly from the CIS-CAT Pro dashboard.
However, you’ll need a paid CIS Membership to access the CIS-CAT Pro. The membership price starts at $1 452 per year. Discounts are available if you opt for a two or three-year membership.
Additionally, CIS Members get access to CIS Build Kits. These are available as Group Policy Objects (GPOs) for Windows and shell scripts for Linux. However, you can download and test a sample Build Kit for free before you decide if it is worth the membership.
The Build Kits also come with detailed deployment instructions for the specific system. In addition, they help to automate the implementation of many of the CIS Benchmarks.
STIG vs. CIS – Applications and Operating System Coverage Winner = Draw
SITGs and CIS benchmarks offer impressive coverage for the most commonly used operating systems and applications. In addition, you’ll find coverage for most modern operating systems, including multiple versions of Windows, macOS, Microsoft Windows Server, Red Hat Enterprise Linux, Amazon Linux, Ubuntu, and CentOS.
The standards cover popular infrastructure software and platforms such as VMware and Cisco. However, the instances where STIG covers specific systems while CIS doesn’t and vice versa.
For example, STIGs do not cover Microsoft Azure, GCP, and AWS. Instead, you’ll need to rely on the DISA Security Requirements Guide (SRG), whose recommendations are more generic than STIGs. Similarly, CIS doesn’t have specific benchmarks for Red Hat JBoss F5 BigIP and IBM Websphere (zip). But you can find STIGs for these environments.
Overall, both STIGs and CIS Benchmarks offer sufficient coverage for most people. However, the choice may come from the specific environment and systems you’re working with. You can simply implement the available standards in this case.


Learn to assess, mitigate and prevent cyber security threats
As threats to our cyber infrastructure increase, so does the need to mount a vigorous defense against them. It’s becoming such a big focus area that the global threat intelligence market is expected to be more than $26 billion by 2028, according to the firm Brandessence Market Research.
Now is the ideal time for you to emerge as a leader in this rapidly growing sector. And earning an online Cyber Security Analyst certificate from the University of North Dakota can help you get there.
By completing this nine-credit certificate program, you can:
Boost your knowledge of the most current trends in cyber security and the challenges organizations face in securing sensitive data and defending against malicious acts.
Enhance your ability to create a secure system by learning to assess potential threats more effectively.
Gain a greater understanding of how human behavior can impact cyber systems.
Prepare to sit for the EC-Council Certified Threat Intelligence Analyst (CTIA) certification exam.
Apply the credits you earn from this certificate toward our online Master of Science in Cyber Security program — that’s 25% of the credits you’ll need for the full master’s.
Expected completion time: This certificate program consists of three 14-week courses, which can be finished in as little as one year, including breaks between terms.
This course examines the critical role human behavior plays in maintaining or conversely endangering cyber security. The science of human attention, perception, learning, and cognition is applied to the problem of maintaining secure cyber systems.
CSCI 585
Vulnerability Assessment
3 Credits
The ability to assess potential threats is a critical prerequisite to creating a secure system. This course will cover the following topics: cyber threats, security requirements, data collection and analysis, and dissemination of results.
EE 611
Emerging Threats and Defenses
3 Credits
Cyber-attacks are a serious economic and security threat. To combat both immediate and future dangers, businesses and governments are investing in cyber security. Understanding trends in cyber-security and how machine-learning techniques defenses can respond to threats is a critical component of protecting networks, infrastructure, and users. This course explores the growing challenges of securing sensitive data and networks to defend against malicious acts.
Are you considering a career change to cyber security?
The University of North Dakota welcomes students from all backgrounds into our graduate certificate program.
Depending on your prior educational and professional experience, you may be required to take up to two foundation courses: Analytical Foundations of Cyber Security and/or Computing Foundations of Cyber Security. Speaking to an enrollment advisor can help you determine whether you meet these prerequisites.
Prepare to sit for industry certification exams
Earn your certificate in as little as 1 year
Apply with no GRE required for admission
Earn credits that can be applied toward a master’s in cyber security


DescriptionHaploid gametes are formed by a specialized cell division called meiosis. During meiosis there is one round of DNA replication, but two rounds of DNA segregation which leaves the daughter cells with half the amount of DNA as the parents. This special division is highly regulated to ensure that exactly one copy of each chromosome is included in each gamete. Once replicated the sister chromatids are held together by cohesion, and the homologous pairs are held together by the synaptonemal complex (SC). Without either of these two complexes, the chromosomes do not segregate properly at meiosis I. Mitotic cohesin is comprised of four subunits SMC1/SMC3/SCC1/SCC3, which form a ring. However, in many organisms there are meiosis specific cohesin subunits that have been discovered, such as Rec8 that substitutes for SCC1. This dissertation aims to gain insight into the meiosis specific complexes in Drosophila. There is evidence for two meiosis specific cohesin complexes functioning in Drosophila. One of the complexes is comprised of SMC1/SMC3/SOLO/SUNN. This complex has a minor role in SC assembly, but, is required for sister centromere cohesion. The other complex demonstrated is SMC1/SMC3/C(2)M/SA and is primarily responsible for SC assembly, is not involved in sister centromere cohesion and, is highly dynamic. To confirm this complex forms cohesin rings, we have made point mutations within the regions of C(2)M which are thought to mediate interactions with SMC1 and SMC3. The data collected from these mutations, to date, reveals that N-terminal amino acid residues may not be important. We are working to learn if there are alternate roles for C(2)M outside of interacting with the SMCs or if the interface between the SMCs and C(2)M is different than proposed.


Abstract
Objectives: To investigate the relationship between passive smoking at home and the incidence of various cancers in a population-based prospective study. Methods: The subjects were 9675 Japanese lifelong nonsmoking women aged over 40 years who lived in three municipalities of Miyagi Prefecture, and completed a self-administration questionnaire in 1984. During 9 years of follow-up, 426 cancers were identified by record linkage to the population-based cancer registry. The data were analyzed using the Cox proportional hazards model. Results: The age-adjusted relative risks (RR) and 95% confidence intervals (CI) of smoking-related cancers and lung cancer for women who had smoking husbands, compared with women whose husbands did not smoke, were 1.7 (0.94-2.9, p = 0.079) and 1.9 (0.81-4.4, p = 0.14), respectively. In contrast, a significant inverse association was observed for breast cancer; the RR (95% CI) was 0.58 (0.34-0.99, p = 0.047). After multivariate adjustment for confounding factors, the risks of smoking-related cancers and breast cancer were materially unchanged. Conclusions: These results show that passive smoking may affect the risk of cancers other than lung cancer.
Keywords Breast neoplasms Environmental tobacco smoke Involuntary tobacco smoke Japan Lung neoplasms Passive smoking Prospective study Tobacco smoke pollution ASJC Scopus subject areas Oncology Cancer Research


What Causes Water Heaters to Burst?
According to the Insurance Institute for Business and Home Safety (IBHS), burst water heaters are one of the most common sources of residential water damage. Fortunately, the plumbers at Deer Valley Plumbing Contractors have all it takes to offer reliable water heater services.
Below are factors that can lead to a burst water heater.
Sediment Build-Up
Hard water contains minerals that build-up at the bottom of your heater over time. This prevents the water from accessing the burner. In turn, your heater will take longer to heat the water. This, in turn, leads to overheating and general deterioration. We recommend that you flush your heater at least once a year to drain out any mineral build-up. You can also turn to a plumber to take care of the buildup.
If the buildup is severe, a water heater replacement might benefit you better.
Rust
Because water heaters are commonly made of steel, they eventually rust due to continuous contact with water. Conventional water heaters have an anode rod that prevents rusting. However, the rod can still deteriorate. Apart from replacing this sacrificial anode rod periodically, prompt water heater repair in Sun City, AZ can also prevent your water heater from bursting.
While a tankless water heater can still rust in other places, you might want to consider getting one the next time you want to upgrade your water heater unit.
Internal Pressure
As the name suggests, your water heater’s temperature and pressure relief valve keeps the pressure and temperature all nice and stable. Needless to say, you could have a real mess in your hands should the valve fail.
Scary as it seems, water heater explosions are actually preventable through regular maintenance and proper use. If you think there might be something wrong with your water heater, don’t think twice about reaching out to our team.
Trust the Pros
At Deer Valley Plumbing Contractors, we offer a wide range of plumbing services including water heater installation, repair, and replacement. Contact us today for efficient, long-lasting solutions.


Authors:Aija Lulle Pages: 76 - 78 Abstract: There is a paradox: While life courses are de facto pluralising, the pull to conform to an imagined standard is strong. In this thematic issue, we unpack the question: To whose standards do people cohere over the course of their lives' We seek the answers through the idea of life course justice, by which we mean a critical inquiry into how wealth, opportunities, and privilege are distributed and constrained in certain life stages and situations, and geographically. The dual focus of this thematic issue is thus on how people forge new ways to learn and work and how they try to resolve life course differences. PubDate: 2022-11-10 DOI: 10.17645/si.v10i4.6269 Issue No:Vol. 10, No. 4 (2022)
Authors:Olga Cara Pages: 79 - 92 Abstract: This article explores the issue of “geography of education” focusing on the pivotal contribution of place to one’s education. The geographic location of schools and the administrative organisation of local authorities that are responsible for state schools in England create sociospatial inequalities that are associated with individual life‐course trajectories and can contribute to the intergenerational transfer of disadvantage. This article focuses on Latvian migrant families for whom better status often can be achieved through being included in the education system of the country. Therefore, the educational achievement of the children who speak Latvian at home but live and attend schools in England is the main focus of this article. The academic attainment of these children is well below not only the national average across all levels of compulsory education but also compared to both monolingual English speakers and all pupils speaking English as an additional language. The article provides evidence that in addition to the sociodemographic individual and family‐level factors geography also plays a significant role in explaining the educational achievement gaps. As the descriptive quantitative analysis of the geographical and educational data indicates, Latvian children are disproportionally present in local authorities where there is a relatively high proportion of low‐quality schools, a higher‐than‐average proportion of individuals with low qualifications and those in low‐qualified jobs. PubDate: 2022-11-10 DOI: 10.17645/si.v10i4.5809 Issue No:Vol. 10, No. 4 (2022)
Authors:Judite Ie, Marit Ursin Pages: 93 - 104 Abstract: While there is a growing body of research on Ciganos/Roma in Portugal, little is known about how Cigano youth transition into adulthood. In this article, we address this gap by drawing on a qualitative study on the transitions of young Ciganos living in Cascais, a coastal municipality in the Lisbon district. Using a multi‐method approach, we explore the life course trajectories of Cigano youth within the areas of education, livelihoods, and marriage, and how these areas shape their transition experiences. The empirical material shows that the transition into adulthood of Cigano youth is influenced by broader structural and socio‐cultural factors. Processes of socialization, ethnicity, and gender restrict young Ciganos’ participation in education and formal labor markets, which increases their vulnerability to marginalization and exclusion in society. Cigano youth, however, initiate different pathways in their life trajectories to achieve adulthood. By focusing on the voices of Cigano youth, we challenge the homogenization of their lives in Portugal and highlight how social age and linked lives shape their transitions into adulthood. PubDate: 2022-11-10 DOI: 10.17645/si.v10i4.5683 Issue No:Vol. 10, No. 4 (2022)


Alignment of people, process and structure are key to an organization’s success. And a critical player in ensuring that alignment is the HR department. When the HR strategies, policies, practices and messages align with organizational goals and culture, GREAT things can happen. Following a significant leadership change within a local community bank, Performance Dimensions Group was hired to support the existing HR function of the organization. Goals for the work included review of existing policies and practices, including performance management, to ensure that the new management and leadership culture was accurately reflected and supported within the organization. In addition to providing behind-the-scenes senior HR “bench strength”, together with the existing team, the organization adopted policies and internal practices that effectively aligned with organizational goals while improving internal customer service.


Since the initial identification of cytochrome P450 monooxygenases (CYPs/P450s), great progress has been made in understanding their structure-function relationship, diversity and application in producing compounds beneficial to humans. However, the molecular evolution of P450s in terms of their dynamics both at protein and DNA levels and functional conservation across kingdoms still needs investigation. In this study, we analyzed 17 598 P450s belonging to 113 P450 families (bacteria -42; fungi -19; plant -28; animal -22; plant and animal -1 and common P450 family -1) and found highly conserved and rapidly evolving P450 families. Results suggested that bacterial P450s, particularly P450s belonging to mycobacteria, are highly conserved both at protein and DNA levels. Mycobacteria possess the highest P450 diversity percentage compared to other microbes and have a high coverage of P450s (≥1%) in their genomes, as found in fungi and plants. Phylogenetic and functional analyses revealed the functional conservation of P450s despite belonging to different biological kingdoms, suggesting the adherence of P450s to their innate function such as their involvement in either generation or oxidation of steroids and structurally related molecules, fatty acids and terpenoids. This study's results offer new understanding of the dynamic structural nature of P450s.


In
Public Value and the Digital Economy, Dr Usman W. Chohan, Director Economic Affairs and National Development at the Centre for Aerospace & Security Studies, explores the digital economy through the lens of Public Value Theory (PVT), to answer questions related to creating and co-creating value at the managerial level. The author identifies a theoretical gap in the understanding of the relationship between the agents ‘who must co-create public value,’ and throughout the book, he emphasises the Value Co-Creation (VCC) approach and the relationship between different agents, i.e., public managers, politicians, civil society, and private interest.
Various practical learnings can be abstracted from the book, which ultimately converges towards digital inclusion and the integration of different social/technological systems. For example, Chohan illustrates the relationship between politicians and public managers (bureaucrats) and highlights the need to form a ‘Parliamentary Technology Office (PTO)’ as a way through which technical assistance can be provided to parliamentarians. The book draws a parallel to the Parliamentary Budgetary Office, which in practical terms can be beneficial for developing and emerging economies. He then explores another significant relationship – public managers and civil society. The Public Value literature has not explored this relationship comprehensively, but this subject has been increasingly gaining traction.
Virtual assets (cryptocurrency specifically) are used across several developed and developing countries. The author, in this regard, highlights the debate related to innovation vs. accountability and freedom vs. security. This helps show how different values in a digital context need to be reconciled, which is a difficult balancing act. Chohan makes prescient observations on trends that are only now emerging, such as regulatory issues related to cryptocurrency that are discussed in the daily news only now, such as El Salvador’s currency switch.
Dr Chohan also highlights a significant link between ‘accommodative value co-creation through Public-Private Partnerships (PPP)’. In the realm of the digital economy, there are often cases where the public sector seeks assistance and collaboration from the private sector due to a lack of expertise in this domain. In practice, it is seen, at the government level, even in Pakistan, that there are working groups and projects formed through PPPs, especially in areas of digital transformation. Moreover, he explains the increasing power of tech companies serving their own private interests and how these companies avoid tax systems. The US, along with other developed economies, has amplified its focus on digital taxation recently, so his exhaustive explanation, about the ways to counter private monopolistic powers through strong digital taxation policies, rings very true.
The book also offers a futuristic vision using the interaction of PVT and the digital medium to explore governance aspects. Furthermore, it delves into new concepts like ‘Decentralized Autonomous Organizations (DAOs)’ by visualising a world where managerial functions are possible without humans. Dr Chohan highlights some of the limitations regarding DAOs but emphasises that this futuristic approach will enhance the value creation process through higher efficiency, greater transparency, and equity-focused results.
This publication is certainly worth reading as it offers an insightful perspective on how to explore the digital economy in detail without being confusing or difficult. In fact, it should be on the must reading list of those in public administration and economics, and particularly those eager to understand the rapidly evolving global digital economy through the Public Value Theory (PVT) perspective. The book presents a comprehensive literature review that zooms in at the micro level to understand the relationships between the different agents of society who can co-create value in a digital context.
M. Mubashir Ehsan is a former Researcher who worked at the Centre for Aerospace & Security Studies (CASS), Islamabad, Pakistan.


Temporary structures should not be designed with the characteristic values of wind velocity or velocity pressure from the Eurocode 1.
Indeed, these characteristic values are determined considering a return period of 50 years, which does not suit the provisional nature of such temporary constructions. Therefore, temporary structures will often be designed with a smaller return period than the usual 50 years.
Return period
Recommended return periods (n) are given in EN1991-1-6:
This return period value is then used to compute the probability factor (c
prob) as per formula (4.2) from EN1991-1-4:
Where:
K is the shape parameter defined in the national appendix. The recommended value is K = 0,2 p = 1/n (with n being the return period, in years) nis the exponent defined in the national appendix. The recommended value is n= 0,5 Be careful, in the c prob formula, n (the exponent) should not be mistaken with n (return period).
Of course, considering a 50-year return period in the above formula leads to c
prob = 1,0.
Therefore, do not expect any benefit from the c
prob factor for structures in use for more than a year:
Wind velocity for a return period of n years is then given by:2
Example
Assume the case of a temporary structure in use from September to November (3 months) in a region where where characteristic wind velocity (for a return period of 50 years) is 24 m/s.
This temporary structure will be designed for a return period of 5 years:
The corresponding probability factor will be:
Resulting I the following wind velocity:
This results in a 15% reduction on wind velocity.
Advance Design results
Advance Design lets the user set the desired return period as well as the shape parameter and the probability exponent.
The corresponding wind velocity is then automatically computed:
Conclusion
Considering the appropriate return period when designing a temporary structure can lead to a significant reduction of wind velocity, thus scaling down the corresponding wind forces.
Not to mention the other parameters, such as the season factor c
season, that can diminish wind action even more.


Vietnam grows on strong footing: German newspaper
Vietnam has seen strong growth in two years of COVID-19 and an increase in foreign direct investment (FDI), according to an article on the Southeast Asian nation’s development freshly published on Germany’s Junge Welt newspaper.
Vietnam was among the fastest-growing countries in the region. (Source: VNA)
The author, Gerhard Feldbauer, noted that while western economies are showing signs of recession, Vietnam's economy is developing well.
The article cited data from the General Statistics Office of Vietnam, which showed that up to 85% of businesses surveyed expressed their optimism in the third quarter of 2022, with only 15% were pessimistic about the coming months.
The author assessed that Vietnam seems to have successfully overcome the difficulties of the world economy caused by the conflict in Ukraine. Its GDP in the second quarter this year expanded by 7.72% over the same period in 2021 and grew sharply from 5.05% in the first quarter. This positive result was mainly due to the strong increase in exports. In June alone, Vietnam's exports jumped by 20% year-on-year.
According to HSBC, Vietnam was among the fastest growing countries in the region because it was one of the few in the world that still attained growth in two consecutive years since the beginning of COVID-19. Vietnam's economy started 2022 on a firm footing. Sticking with a policy to "co-live with the virus," the country has accelerated its vaccination drive and gradually removed local restrictions, fuelling consumer sentiment, leading to an ongoing rebound in local consumption.
HSBC noted that Vietnam's foreign direct investment is also increasing, for example, Samsung recently started building a 220 million USD R&D centre in Hanoi, its largest in Southeast Asia, and is set to expand its plants in northern Bac Ninh and Thai Nguyen provinces. Meanwhile, Apple has also moved 11 factories from Taiwan to Vietnam.


Investment interest in wind and solar energy projects planned to offer their output through power purchase agreements (PPAs) has grown sharply, as indicated by a large number of preliminary PPA agreements submitted by investors to power grid operator IPTO for entry into a priority-status category established through a ministerial decision.
A 1,500-MW limit that had been set by the ministerial decision for this category has been greatly exceeded, according to energypress sources. The energy ministry has already decided to elevate this limit, but it remains unclear if the bar will be raised sufficiently to fully cover the heightened level of investment interest being declared.
RES producers are turning to PPAs in greater numbers as a result of lower fixed tariffs being offered at RES auctions staged by RAE, the Regulatory Authority for Energy, market officials have pointed out.
Another key factor behind this trend is the greater need for green power generation being expressed by suppliers, due to a wholesale cap, as well as industrial players, all of which is creating favorable PPA conditions offering RES producers higher fees.
A considerable amount of grid capacity for PPA-based RES projects is expected to be made available through the cancellation, by energy authorities, of RES projects that have held connection terms for quite some time but inexplicably remained stagnant.


Case Abstract
This case study explores the advantages and limitations of conducting focus groups online. Though virtual focus groups have long been positioned as supplemental or inferior alternatives to in-person focus groups, this case study emphasizes the flexibility, accessibility, and possibility of conducting focus groups virtually. Providing examples from virtual focus groups conducted during a qualitative research course, this case study first discusses positive aspects of online focus groups, such as easy incorporation of complementary technology and participation access for a diversity of participants. The case study then explores the challenges and limitations of virtual focus groups, including the facilitators’ technological knowledge and participants’ internet reliability. This case study ends by acknowledging that there are a range of logistical concerns that will inevitably shape online focus groups, including facilitators’ and participants’ familiarity with online platforms and dependability of technology and internet access. However, despite these challenges, there are a range of advantages, such as accommodating participants’ unique needs, offering multiple modes of participation, and providing reasonably equitable access to any media used in the interactions. Ultimately, the authors argue that like any research method, moving focus groups online does not make them inherently better or worse; it does, however, require some new considerations and strategies for implementation, which offer substantial opportunities for focus group research.


Beskrivning
WINNER 2016 Grawemeyer Award in Education Helping students develop their ability to deliberate political questions is an essential component of democratic education, but introducing political issues into the classroom is pedagogically challenging and raises ethical dilemmas for teachers. Diana E. Hess and Paula McAvoy argue that teachers will make better professional judgments about these issues if they aim toward creating ”political classrooms,” which engage students in deliberation


The origins of Brandy were clearly tied to the development of distillation. While the process was known in classical times, it wasn’t used for significant beverage production until the 15th century.
Initially wine was distilled as a preservation method and as a way to make it easier for merchants to transport. It is also thought that wine was originally distilled to lessen the tax which was assessed by volume. The intent was to add the water removed by distillation back to the brandy shortly before consumption. It was discovered that after having been stored in wooden casks, the resulting product had improved over the original distilled spirit. In addition to removing water, the distillation process led to the formation and decomposition of numerous aromatic compounds, fundamentally altering the composition of the distillate from its source. Non-volatile substances such as pigments, sugars, and salts remained behind in the still. As a result, the taste of the distillate was often quite unlike that of the original source.
Brandy is a spirit produced by distilling wine. Brandy generally contains 35–60% alcohol by volume and is typically drunk as an after-dinner digestif. Quality brandies are aged in wooden casks, others are coloured with caramel colouring to imitate the effect of aging, and some are produced using a combination of both aging and colouring. Varieties of wine brandy can be found across the winemaking world. Among the most renowned are Cognac and Armagnac from southwestern France.
In a broader sense, the term “Brandy” also denotes liquors obtained from the distillation of pomace (yielding pomace brandy) or mash or wine of any other fruit (fruit brandy). These products are also called eau de vie (which translates to “water of life”).
Northern Italy is also noted since the Middle Ages for another type of wine spirit, Grappa, which is generally colourless but has some top-shelf varieties called barrique which are aged in oak casks and achieve the same caramel colour as regular brandies.


Zero-emission vehicles are increasing popular on Queensland, Australia roads, with the Tesla Model 3 the most prevalent, according to a report in the Australian edition of
Fleet Auto News.
The Queensland government’s August Electric Snapshot, the Tesla Model 3 represented 55% of the 5,695 battery electric vehicles (BEV) registered in the state, a significant increase from the 2,862 total BEVs recorded in January 2021.
The BEV growth in Queensland is notable since unlike other states such as Victoria, New South Wales and South Australia, Queensland has not offered an electric vehicle purchase rebate,
Fleet Auto News pointed out. However, the Queensland’s annual registration is cheaper, and the new-car stamp duty is less than a four-cylinder internal combustion engine.
The Queensland government’s Electric Vehicle Snapshot provides an overview of measurable zero emission vehicle (ZEV) statistics, including registrations, vehicle market share and usage figures for the Queensland Electric Super Highway, a three-phase network of fast-charging stations.
0 Comments


Increasing certain minerals in the diet can help with lowering your systolic blood pressure, typically within just a few days of eating them. The more of these minerals you have circulating in the digestive tract and bloodstream, the less sodium you'll typically retain from food. That means less bloating, lower blood pressure, and a more true weight!


The web Browser you are currently using is unsupported, and some features of this site may not work as intended. Please update to a modern browser such as Chrome, Firefox or Edge to experience all features Michigan.gov has to offer.
CAV Corridor CAV Corridor
The vision for the corridor is intended to create lanes that are purpose-built to accelerate and enhance the full potential of CAVs and move people. To achieve this, Cavnue will work with regional partners to plan, design, and develop the world’s most sophisticated roadway, combining innovations in physical, digital, coordination, and operational infrastructure to help increase the safety, efficiency, resilience and operations of roadways, and improve the mobility experience for users by enabling a faster and more coordinated dedicated autonomous mobility corridor. At its core, the project is designed to be “future-proofed” and evolve to meet transportation goals, beginning with connected buses and shared mobility vehicles such as vans and shuttles, and expanding to additional types of CAVs such as freight and personal vehicles.
The project will advance key policy goals, including improving safety, achieving neutrality among vehicle OEMs through standards-based approaches, enhancing accessibility, affordability, and equity, and aligning with regional planning, thus encouraging innovation, R&D, economic development, open data access and shared learnings, cybersecurity, and replicability. Throughout the planning and development process, stakeholders will carefully evaluate potential impacts on the transportation workforce and ensure that it supports good-paying jobs.
The project envisions connecting Detroit and Ann Arbor along with key communities and destinations along Michigan Avenue and Interstate 94 in Wayne County and Washtenaw County with an innovative infrastructure solution that allows for a mix of connected and autonomous vehicles, traditional transit vehicles, shared mobility, and freight and personal vehicles. It will build on existing investments made by the state of Michigan and local communities in smart infrastructure and transit and will link key destinations including the University of Michigan, Detroit Metropolitan Airport, and Michigan Central Station. The corridor includes up to a dozen Opportunity Zones, where expanded mobility will connect individuals, small businesses and communities to Southeast Michigan’s most important industrial, technological, and academic clusters. This includes leading test tracks, universities, automotive companies, and key economic anchors.


Eligible high-earning foreign professionals can apply for a Personalised Employment Pass. Pass holders have greater job flexibility than with other work passes. However, they need to meet certain requirements to hold the pass.
Who is eligible
You can apply for a Personalised Employment Pass (PEP) if you are:
An overseas foreign professional and your last drawn fixed monthly salary overseas was at least $18,000. Your last drawn salary should have been within 6 months before you apply. An existing Employment Pass holder earning a fixed monthly salary of at least $12,000.
From 1 September 2023, the fixed monthly salary criteria for both existing EP holders and overseas foreign professionals will be raised to $22,500. This is benchmarked to the top 10% of EP holders.
Who is not eligible
You are not eligible for the PEP if you are:
An Employment Pass holder under the sponsorship scheme. A freelancer or foreigner who intends to work on a freelance-basis. A sole proprietor, partner or where a director is also a shareholder in an ACRA-registered company. A journalist, editor, sub-editor or producer. Note: You are not allowed to start a business or conduct any form of entrepreneurial activity while on a PEP. If you intend to do so, you should apply for an EntrePass or Overseas Networks & Expertise Pass. Requirements of the pass
To keep holding a PEP, you must:
Benefits of the PEP
The PEP gives you greater job flexibility than other work passes:
You can generally hold a job in any sector. However, the PEP does not exempt you from complying with registration requirements to practise in Singapore for professions such as medicine, dentistry, pharmacy, architecture, law, etc. You do not need to re-apply for a new pass if you change jobs; you only need to notify us. You can stay in Singapore for a continuous period of up to 6 months without a job to search for new employment. Passes for family members
If you hold a PEP, you can bring in your family members on these passes:
Dependant's Pass for your:
Spouse (legally married). Children under 21 years old
Long-Term Visit Pass for your:
Common-law spouse Unmarried handicapped children aged 21 and above Unmarried stepchildren under 21 years old Parents
You need to submit a separate application for each family member even if they currently hold a Dependant’s Pass or Long-Term Visit Pass. You can submit their applications along with the PEP application.


Overview
TMR is planning to connect growing communities with more frequent and reliable train services between Brisbane, Logan and the Gold Coast.
To support growing population and rail patronage demand, TMR needs to double the number of Beenleigh and Gold Coast train services over the next 20 years. The rail line between Kuraby and Beenleigh is a key capacity bottleneck on the rail corridor.The Queensland Government, together with the Australian Government, is planning to increase the number of tracks between Kuraby and Beenleigh from two to four, with modernised rail systems, stations upgrades and level crossing removals. Currently, trains between Kuraby and Beenleigh share a single track in each direction, limiting the number of peak services that can run. Additional tracks will require a wider corridor and track straightening in some areas.
Have your say
Thank you to all the property owners and community members who participated in the 8-week consultation process for the project during September and October. Consultation has now closed.
TMR appreciates the feedback received and thank everyone who participated in engagement events or provided feedback via the survey and interactive map during the consultation period.
Feedback from the community and stakeholders will now be reviewed and used to refine the project design. The Australian and Queensland governments will then decide on whether to fund the project and timeframes for detailed design and construction.
Submissions closed on
31 October 2021.


Innovations in artificial intelligence and advanced analytics are creating performance and efficiency opportunities across industries and markets. Within pharmaceutical sales and marketing, a domain that also has a significant reliance on human functions such as expertise and reasoning, the impact of AI can be substantial.
Companies that use AI to orchestrate a cohesive customer experience will drive stronger differentiation, better customer access and higher sales impact. This article provides specific opportunities for machine and human integration in pharmaceutical sales and marketing and insight into how to truly realize the value of AI enablement.


Every fall, Monmouth County, New Jersey home and business owners brace for the onslaught of three invasive insect pests looking for a warm place to spend the winter. Stink bugs, box elder bugs and Asian ladybird beetles overwinter in building soffits, attics, wall and ceiling voids.
In the fall, these insects may gather by the thousands on sunny exterior walls searching for a way indoors. In some neighborhoods, these pests can be so numerous that they coat siding, decks and patios and must be constantly swept away.
Stinky House Guests
These overwintering insects make unpleasant house guests. When startled or crushed, they emit a foul, lingering odor and can also stain fabrics and wallpaper with their excrement. As temperatures drop, these insects will seek shelter in wall voids, reappearing in the spring to return to the outdoors. However, warm winter days may bring these pests out of hiding to bask on sunny interior walls.
Top Overwintering Pests Stink bugs.A significant agricultural pest, stink bugs cost New Jersey farmers millions of dollars each year. These insects have thin, shield-shaped bodies that allow them to slip through window and door frames. Usually dull brown or gray, stink bugs may also be green, blue or black. Box elder bugs.Black with distinctive red or orange markings, box elder bugs feed on box elder, ash and maple trees but pose no threat to vegetation. Asian ladybird beetles.Orange with black spots, these Asian transplants are beneficial agricultural pest deterrents but are so numerous they can overwhelm buildings in the fall.
Don’t let overwintering pests bug you. Call Allison Pest Control’s pest extermination experts for safe, effective pest control.


Glover’s Reef is a marine reserve established in 1993 to recover Caribbean spiny lobster populations and other exploited species. This reserve covers 74 km2, including different habitats: coral reefs, seagrasses, and mangroves. In 1998, when monitoring and surveillance began consistently, the density of lobsters inside and outside the reserve was similar. After three years, lobsters were three times more abundant and had biomass 45 times higher inside the marine reserve than outside.
Belize Case – Glover’s Reef
Alianza Kanan Kay
- February 2, 2022 - 0 comments


Life changes, such as moving to a new home or to an entirely new city, can be difficult for most people, including teens. Dr. Sarah Garwood, Adolescent Medicine Specialist at St. Louis Children’s Hospital, shares tips for how you can help your teen adjust to moving, including providing empathy and validation, involving them in the planning process, and focusing on the positives of this new opportunity. Moving can be a great adventure, and setting the example of a positive attitude during the changes that come with a move can help ease the adjustment for both you and your child.


Title Date of Graduation
5-2015
Document Type
Dissertation (PhD)
Program Affiliation
Molecular Carcinogenesis
Degree Name
Doctor of Philosophy (PhD)
Advisor/Committee Chair
Kevin M. McBride, Ph.D
Committee Member
Rick A. Finch, Ph.D.
Committee Member
Ellen R. Richie, Ph.D.
Committee Member
Richard D. Wood, Ph.D.
Committee Member
Mark T. Bedford, Ph.D.
Abstract
Activation-induced cytidine deaminase (AID) is a mutagenic enzyme that is expressed in mammalian B-cells and initiates the antibody diversification processes of somatic hypermuntation (SHM) and isotype class switch recombination (CSR). AID is targeted to the immunoglobulin gene locus where it deaminates cytosines to generate uracil residues in DNA. This generates guanine-uracil (U:G) mismatch lesion which are recognized by uracil DNA glycosylase (UNG), a DNA repair enzyme that removes uracil from DNA and triggers downstream repair of the lesion. While UNG is a ubiquitously expressed DNA repair enzyme, its recognition and removal of AID introduced uracils is essential in both SHM and CSR. Mice lacking AID or UNG are deficient in SHM and CSR resulting in a compromised immune system.
Due to its mutagenic activity AID is heavily regulated by diverse mechanisms including post-translational modification. Here we investigate the effect of AID phosphorylation in CSR, and identify potential phospho-AID interacting factors. Using an
in vitro CSR assay we show that preventing AID phosphorylation at novel sites threonine-150, serine-169 and tyrosine-184 significantly reduces CSR efficiency. We identified potential phospho-AID binding proteins using a protein domain array screen, which may prove to be important in modulating AID activity.
Herpes viruses posses a large double stranded DNA genome and many carry a form of uracil DNA glycosylase. Many of these viruses, such as Epstein-Barr virus (EBV), infect mammalian B-cells. Our experiments show that viral UNGs are able to partially restore CSR when expressed in B-cells from
Ung deficient mice. Intriguingly we discovered that viral UNGs suppress CSR when expressed in wild-type B-cells, and that UNG catalytic activity is not required for this suppressive effect. We also found that viral UNG expression in mouse B-cells reduces the frequency of AID induced IgH-cMYC translocations, suggesting that viral UNG may play a role in protecting the host cell genome from damage. These studies have revealed a novel mechanism by which herpes viruses might impede the host immune system.


Title
Polymer Nanoparticles for Optimized Gene Delivery to Mucosal Tissues
Date of Award
Fall 10-1-2021
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Engineering and Applied Science
First Advisor
Saltzman, Mark
Abstract
After decades of pre-clinical and clinical research, gene therapies are finally achieving clinical success. There is rapidly growing interest in using the potential of nucleic acids to develop new treatment options in diverse fields of medicine, but effective gene therapies are still limited by effective delivery systems. Localized gene delivery to mucosal tissues—which include the eyes, respiratory system, digestive system, and female reproductive tract—are being developed to treat disorders and diseases ranging from cystic fibrosis to HIV. However, agent penetration through the mucus barrier that is common to all of these tissues poses a significant challenge to delivery vector design. Many groups have reported that coating delivery vehicles with polyethylene glycol (PEG) can improve diffusion through mucus, but PEG coatings can also inhibit gene delivery.In this dissertation, we examined the effect of PEGylation on gene delivery with nanoparticles made of poly(amine-co-ester) (PACE). PACEs are family of cationic polymers that can effectively deliver a variety of nucleic acids, such as DNA plasmids, mRNA and siRNA. By tuning the lactone content, PACE can be synthesized as a liquid polymer that forms polyplexes by electrostatic attraction to nucleic acids—or as a solid polymer that forms nanoparticles with sustained nucleic acid release. We developed a method of producing PACE polyplexes with tunable PEG content by blending different ratios of PACE and PEG-conjugated PACE. PACE polyplexes with PACE-PEG content as low as 0.25% by weight were more stable than non-PEGylated polyplexes over 3 days, but similar percentages of PACE-PEG inhibited transfection of pDNA, mRNA, and siRNA in vitro. By contrast, incorporation of up to 5% PACE-PEG significantly improved intratracheal mRNA transfection to the lung compared to non-PEGylated polyplexes, highlighting the potential benefits of optimized PEGylation for gene delivery. Next, we tested PACE polymers with modified end group chemistry to enhance endosomal escape of mRNA and improve protein expression. We demonstrated that intratracheal delivery of mRNA polyplexes with end-capped PACE (1,3-diamino-2-hydroxypropane) produced 100-fold higher protein expression in the lung compared to unmodified polymer. Blending end group-modified PACE with PACE-PEG further improved polyplex distribution and mRNA transfection in the lung. Our results indicate that PACE end-capped with 1,3-diamino-2-hydroxypropane and blended with 10% PACE-PEG is a promising delivery vehicle for inhaled mRNA therapies. Finally, we evaluated the safety and kinetics of bioadhesive nanoparticles (BNPs) when administered to the vaginal mucosa of non-human primates. We administered BNPs formed from a block copolymer of poly(lactic acid) and hyperbranched polyglycerol—a system previously shown to be effective in mice for intravaginal delivery of anti-retroviral drugs. We used PET imaging to examine the retention and distribution of 89Zr-labeled BNPs after vaginal application and found that 1.7% of BNPs were retained in the vaginal canal for 24 hours, and BNPs were still detectable after at least 5 days. Additionally, we tracked inflammatory vaginal biomarkers before and after BNP administration to confirm vehicle safety. We observed no significant increase in TNFα, IL-6, MIP-1α, and IL-1RA, suggesting that BNPs are non-reactive and biocompatible, even after multiple vaginal doses. Stealthy nanoparticles—with coatings of PEG or HPG—are promising vehicles for the delivery of genes or drugs to mucosal tissues. This dissertation work concludes that optimized PEGylation can significantly improve the stability and pulmonary transfection efficiency of PACE polyplexes. We also highlight the promise of bioadhesive HPG coatings for safe and prolonged delivery of vaginal therapeutics.
Recommended Citation
Grun, Molly, "Polymer Nanoparticles for Optimized Gene Delivery to Mucosal Tissues" (2021).
Yale Graduate School of Arts and Sciences Dissertations. 343. https://elischolar.library.yale.edu/gsas_dissertations/343


Heme sensing and detoxification by HatRT contributes to pathogenesis during Clostridium difficile infection AUTHORS PMID: 30576368 [PubMed]. ABSTRACT
Clostridium difficile is a Gram-positive, spore-forming anaerobic bacterium that infects the colon, causing symptoms ranging from infectious diarrhea to fulminant colitis. In the last decade, the number of C. difficile infections has dramatically risen, making it the leading cause of reported hospital acquired infection in the United States. Bacterial toxins produced during C. difficile infection (CDI) damage host epithelial cells, releasing erythrocytes and heme into the gastrointestinal lumen. The reactive nature of heme can lead to toxicity through membrane disruption, membrane protein and lipid oxidation, and DNA damage. Here we demonstrate that C. difficile detoxifies excess heme to achieve full virulence within the gastrointestinal lumen during infection, and that this detoxification occurs through the heme-responsive expression of the heme activated transporter system (HatRT). Heme-dependent transcriptional activation of hatRT was discovered through an RNA-sequencing analysis of C. difficile grown in the presence of a sub-toxic concentration of heme. HatRT is comprised of a TetR family transcriptional regulator (hatR) and a major facilitator superfamily transporter (hatT). Strains inactivated for hatR or hatT are more sensitive to heme toxicity than wild-type. HatR binds heme, which relieves the repression of the hatRT operon, whereas HatT functions as a heme efflux pump. In a murine model of CDI, a strain inactivated for hatT displayed lower pathogenicity in a toxin-independent manner. Taken together, these data suggest that HatR senses intracellular heme concentrations leading to increased expression of the hatRT operon and subsequent heme efflux by HatT during infection. These results describe a mechanism employed by C. difficile to relieve heme toxicity within the host, and set the stage for the development of therapeutic interventions to target this bacterial-specific system.


Article Title Abstract
There is a dearth of research about the experiences of the Latino population in raising a child with autism spectrum disorder (ASD). This includes a lack of cross-cultural perspectives and perspectives from fathers. Although there are similar experiences in raising a child with ASD among parents, we hypothesize that there will be different experiences due to culture. The current study is an exploratory qualitative research design, where we sought to understand the experiences of Latino and non-Latino White parents who are raising a child with ASD. Results indicated similarities across all families that include: self-efficacy beliefs, challenges, stress and coping, and goals and expectations. Different themes emerged in the Latino families that were not evident in non-Latino White families. Specifically, Latino families emphasized religion and faith, involvement and love, extended family support, Latino pride, and importance of collaboration. Implications are discussed for further cross-cultural family studies, the need to inform healthcare professionals on the early signs of ASD especially with regard to culture, and the importance of collaboration among parents and professionals.
Keywords
Autism Spectrum Disorder, Parents, Exploratory Research, Qualitative Research
Acknowledgements
The authors gratefully acknowledge the families who participated in the study.
Publication Date
8-13-2017
Creative Commons License This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 International License. DOI
10.46743/2160-3715/2017.3261
Recommended APA Citation
Casillas, N., Vigil, D., & Wang, H. (2017). Latino and Non-Latino White Parents’ Experiences Raising their Child with ASD: An Exploratory Study.
The Qualitative Report, 22(8), 2173-2195. https://doi.org/10.46743/2160-3715/2017.3261


Cytosolic phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme that is highly expressed in the liver and kidney but is also expressed at lower levels in a variety of other tissues where it may play adjunct roles in fatty acid esterification, amino acid metabolism, and/or TCA cycle function. PEPCK is expressed in the enterocytes of the small intestine, but it is unclear whether it supports a gluconeogenic rate sufficient to affect glucose homeostasis. To examine potential roles of intestinal PEPCK, we generated an intestinal PEPCK knockout mouse. Deletion of intestinal PEPCK ablated ex vivo gluconeogenesis but did not significantly affect glycemia in chow, high-fat diet, or streptozotocin-treated mice. In contrast, postprandial triglyceride secretion from the intestine was attenuated in vivo, consistent with a role in fatty acid esterification. Intestinal amino acid profiles and
13C tracer appearance into these pools were significantly altered, indicating abnormal amino acid trafficking through the enterocyte. The data suggest that the predominant role of PEPCK in the small intestine of mice is not gluconeogenesis but rather to support nutrient processing, particularly with regard to lipids and amino acids. NEW & NOTEWORTHY The small intestine expresses gluconeogenic enzymes for unknown reasons. In addition to glucose synthesis, the nascent steps of this pathway can be used to support amino acid and lipid metabolisms. When phosphoenolpyruvate carboxykinase, an essential gluconeogenic enzyme, is knocked out of the small intestine of mice, glycemia is unaffected, but mice inefficiently absorb dietary lipid, have abnormal amino acid profiles, and inefficiently catabolize glutamine. Therefore, the initial steps of intestinal gluconeogenesis are used for processing dietary triglycerides and metabolizing amino acids but are not essential for maintaining blood glucose levels. Keywords: amino acids; cataplerosis; gluconeogenesis; glyceroneogenesis; small intestine.


WHAT THIS MEANS FOR MERCHANTS
The term ‘chargeback’ is often thought to be synonymous with ‘transaction dispute’. Technically, the two aren’t interchangeable.
All chargebacks are transaction disputes, but not all transaction disputes are chargebacks.
Regulations E and Z give cardholders the right to dispute transactions, but only the card brands offer a chargeback process.
Why does that matter?
Think about your dispute management strategy. What does it entail? Are you focused solely on activity facilitated by the card brands — alerts, order validation, and chargebacks? If so, you might not have a complete understanding of the customer experience.
Chargeback data is incredibly valuable. It can help you identify hidden issues and resolve problems at their source. However, there are several reasons why a consumer complaint might not ever make it to a chargeback — an issuer’s choice to limit protections is just one of the reasons. Therefore, chargebacks shouldn’t be the only metric you use to gauge customer satisfaction, the effectiveness of your processes, and the risk of potential revenue loss.
Focus on creating an exemplary customer experience — one that ensures satisfaction and resolves issues without the need of a chargeback.


Diabetes: To control diabetes, drink this one thing mixed with milk every night before going to bed.
Diabetes: The disease of diabetes is spreading rapidly. This disease is caused by increased blood sugar level and non-release of pancreatic hormones. Health experts advise diabetic patients to exercise daily and avoid sweets. This keeps diabetes under control. If you are also a diabetic patient and want to control sugar, then consume milk daily. At the same time, drinking something mixed with milk before going to bed at night keeps the sugar under control. Let’s know everything about it…
Milk: It has been revealed in a research that drinking milk every morning helps in controlling blood sugar. Milk is successful in slowing down the digestion process of carbohydrates. This keeps sugar under control throughout the day. For this, diabetic patients should consume milk every morning. Linseed: Linseed is no less than a boon for health. Many essential nutrients are found in it, including fiber, protein, zinc, anti-oxidant, iron, omega-3 fatty acids, which prove beneficial for health. Flaxseed medicines are similar, especially for obesity and diabetes. For this, diabetic patients can consume linseed daily on the advice of a doctor. Along with this, due to the presence of fiber, flax seeds prove to be helpful in controlling weight. Along with this, bad cholesterol also remains under control. how to consume
For this, you can mix one spoon of flaxseed powder in a glass of warm milk and drink it every night before going to bed. Its use helps in controlling diabetes. Along with this, you can consume cinnamon mixed with milk.


Vanguard is a different kind of investment company. It was founded in the United States in 1975 on a simple but revolutionary idea: that an investment company should manage its funds solely in the interests of its clients.
This is a philosophy that has helped millions of people around the world to achieve their goals with low-cost, uncomplicated investments.
It's what we stand for: value to investors.
*Data as of 30 June 2022. Monetary figures are in US dollars.
**The Vanguard Group, Inc. is owned by Vanguard's US-domiciled funds and ETFs. Those funds in turn are owned by their investors.
*** Crew headcount updated annually as of 12/31/2021.
It’s easy and often tempting to focus on short-term market movements, the economy, manager ratings or the performance of individual funds. This may lead you to overlook the basic principles that we believe will give you the best chance of success.
These principles are based on a simple idea: Focus on what you can control.
Create clear, attainable goals
The first step in creating a financial plan is to set measurable and attainable goals. This helps investors stay focused and avoid unnecessary risks.
In the market, as in life, there will always be unexpected twists and turns. That’s why plans can change over time. But planning early can help investors develop a more goal-oriented asset allocation, avoid mistakes and enjoy the feeling of not leaving their future up to chance.
Develop a suitable asset allocation using broadly diversified funds
A successful investment strategy is based on a diversified portfolio aligned with its objective. By diversifying their investments across markets, regions and sectors, investors can avoid unnecessary risks and limit volatility.
The higher the return potential of an investment, the greater its risk and potential volatility. That’s why the asset allocation should be based on realistic return expectations and a thorough understanding of one’s own risk tolerance.
Minimise cost
You can’t control the markets, but you can control how much you pay to invest. Investors should always be aware of their costs, since every euro that you pay in fees comes at the expense of your potential return.
In fact, our research suggests that lower-cost investments have tended to outperform higher-cost alternatives. So, when it comes to investing money, a higher price does not always indicate better quality.
Stay focused and think long-term
Investing evokes emotions that can disrupt the plans of even the most sophisticated investors – often at the expense of returns. When investors sell assets out of fear or follow a market trend, they often end up trailing the market. And every time they reconfigure their portfolio, they may incur costs or be subject to taxation.
You can counter emotions with discipline and a long-term perspective. This can help you stick to your plan.
Investors can't control the markets, but they can control costs. Every pound paid in fees is a pound less of potential return. That is why we focus on low-cost, uncomplicated funds that can help investors meet their long-term goals. Explore our range below.
View all equity funds registered for sale in your country
View all fixed income funds registered for sale in your country
View all multi-asset funds registered for sale in your country
We don’t offer investment advice based on personal circumstances. If you are unsure whether the products mentioned on this site are suitable for you, please speak to a financial adviser.
Past performance is not a reliable indicator of future results. The value of investments, and the income from them, may fall or rise and you may get back less than you invested.
Investment in one or more units or shares of any UCITS is not exempt from risk. Before any investment, we recommend that you read the relevant prospectus, and especially its section on risks, and Key Investor Information Document(s) (“KIID”).


This article is free to access.
Background: Tibetan chickens, a unique native breed in the Qinghai-Tibet Plateau of China, possess a suite of adaptive features that enable them to tolerate the high-altitude hypoxic environment. Increasing evidence suggests that long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play roles in the hypoxic adaptation of high-altitude animals, although their exact involvement remains unclear. Results: This study aimed to elucidate the global landscape of mRNAs, lncRNAs, and miRNAs using transcriptome sequencing to construct a regulatory network of competing endogenous RNAs (ceRNAs) and thus provide insights into the hypoxic adaptation of Tibetan chicken embryos. In total, 354 differentially expressed genes (DE genes), 389 differentially expressed lncRNAs (DE lncRNAs), and 73 differentially expressed miRNAs (DE miRNAs) were identified between Tibetan chickens (TC) and control Chahua chickens (CH). GO and KEGG enrichment analysis revealed that several important DE miRNAs and their target DE lncRNAs and DE genes are involved in angiogenesis (including blood vessel development and blood circulation) and energy metabolism (including glucose, carbohydrate, and lipid metabolism). The ceRNA network was then constructed with the predicted DE gene-DE miRNA-DE lncRNA interactions, which further revealed the regulatory roles of these differentially expressed RNAs during hypoxic adaptation of Tibetan chickens. Conclusions: Analysis of transcriptomic data revealed several key candidate ceRNAs that may play high-priority roles in the hypoxic adaptation of Tibetan chickens by regulating angiogenesis and energy metabolism. These results provide insights into the molecular mechanisms of hypoxic adaptation regulatory networks from the perspective of coding and non-coding RNAs.
CITATION STYLE
Zhang, Y., Su, W., Zhang, B., Ling, Y., Kim, W. K., & Zhang, H. (2021). Comprehensive analysis of coding and non-coding RNA transcriptomes related to hypoxic adaptation in Tibetan chickens.
Journal of Animal Science and Biotechnology, 12(1). https://doi.org/10.1186/s40104-021-00582-2


The SYSVAC registry includes a variety of systematic reviews, including living, rapid and umbrella reviews, allowing users to search for reviews using free text and keywords (e.g., disease/pathogen, population). Reviews in the registry have been assessed for quality, using the AMSTAR 2 (A MeaSurement Tool to Assess systematic Reviews 2) appraisal tool.
To include the most relevant systematic reviews in the field, registry staff regularly conduct searches of multiple databases, including Medline, Embase, and The Cochrane Library. For the registry’s December 2020 launch, priority was given to systematic reviews related to COVID-19. Systematic reviews covering more diseases/pathogens have been added since 2021.


Alaska is the most tectonically active area in North America with abundant seismic and volcanic activities, and its unique lithosphere structures record a series of tectonic events of collision and deformation. Studying the subsurface structures is crucial for understanding these tectonic processes. Seismic imaging, which builds the Earth’s velocity model by analyzing the travel times of seismic waves, is one of the most important method to map the subsurface structures. The recent increasingly available seismic data in Alaska due to the deployment of USArray provides us with an unprecedented opportunity to conduct seismic imaging in that area.
In this presentation, I will start with a brief overview of the historic and current tectonics in Alaska. Then I will use some examples to illustrate how can we study the subsurface structures by mapping the velocities. Finally, I will talk about our seismic imaging project in Alaska using ambient noise data and the full-waveform inversion technique, including a short introduction of our method and a demonstration of our preliminary result.


Abstract
Periodontitis is a prevalent disease characterized by the loss of periodontal supporting tissues, bone, periodontal ligament, and cementum. The application of a bone tissue engineering strategy with Decellularized Human Amniotic Membrane (DAM) with adipose-derived stromal cells (ASCs) has shown to be convenient and valuable. This study aims to investigate the treatments of a rat periodontal furcation defect model with DAM, ASCs, and a mineralized extracellular matrix (ECM). Rat ASCs were expanded, cultivated on DAM, and with a bone differentiation medium for four weeks, deposited ECM on DAM. Periodontal healing for four weeks was evaluated by micro-computed tomography and histological analysis after treatments with DAM, ASCs, and ECM and compared to untreated defects on five consecutive horizontal levels, from gingival to apical. The results demonstrate that DAM preserves its structure during cultivation and healing periods, supporting cell attachment, permeation, bone deposition on DAM, and periodontal regeneration. DAM and DAM+ASCs enhance bone healing compared to the control on the gingival level. In conclusion, DAM with ASC or without cells and the ECM ensures bone tissue healing. The membrane supported neovascularization and promoted osteoconduction.
Keywords Adipose-derived stromal cells Bone tissue engineering Human amniotic membrane Periodontal regeneration Stem cell transplantation ASJC Scopus subject areas Chemical Engineering (miscellaneous) Process Chemistry and Technology Filtration and Separation


Sexual assault can impact a survivor physically and emotionally. In fact, sexual violence survivors often experience significant psychological impacts, both in the short term and in the long term. These effects can lead to the development of unhealthy coping mechanisms, substance abuse, and mental illnesses such as Post-Traumatic Stress Disorder (PTSD), anxiety, and depression, impacting how a survivor experiences his or her daily life.
#1: Depression
Depression is a mood disorder that involves feelings of sadness and hopelessness, and is a common long-term effect that sexual assault survivors experience. These depressive thoughts and feelings can interrupt a survivor’s regular thoughts, behaviors, and relationships with others.
Depression is not a sign of weakness — it is incredibly common in the United States, with an estimated 17.3 million adults experiencing depression in 2017. While depression can make certain activities difficult and reduce the enjoyment of life, survivors can treat this condition through medication, therapy, and counseling.
#2: Post-Traumatic Stress Disorder
PTSD is another common psychological effect of sexual assault. Commonly associated with military members, a person can develop PTSD after a traumatic event — and sexual assault qualifies as a type of trauma. There are three main symptoms of PTSD.
Re-experiencing the trauma through intrusive thoughts, flashbacks, and dreams Changing behaviors or actions to avoid scenarios that remind the survivor of the traumatic event Feeling on edge constantly, experiencing insomnia, exhibiting agitation, and other signs of hyper-arousal
Living with PTSD can be difficult and interfere with daily life. A survivor may feel like he or she is in constant danger, and feel heightened symptoms of anxiety, stress, and fear. However, many treatment options are available for people with PTSD, including service dogs, therapy, and medication.
#3: Substance Abuse
The aftermath of sexual assault can lead survivors to develop unhealthy coping mechanisms, including reliance on substances such as drugs and alcohol. Survivors may use alcohol or drugs to feel better, relieve the pain associated with sexual assault, or to numb themselves. A lack of an effective support system and confusion may also lead to substance abuse.
Substance abuse can lead to significant physical, emotional, and interpersonal damage over time, harming relationships, employment, quality of life, and more. It can be difficult to differentiate substance abuse from healthy drinking habits.
If a survivor experiences any of the following warning signs, he or she should seek professional treatment as soon as possible.
Poor performance at work or school due to substance use Driving while under the influence of alcohol or drugs Lying about or hiding substance use from friends and family Taking money or valuables from others to pay for substances Breaking the law while using substance abuse Losing interest in activities or hobbies to use substances
The long-term psychological effects of sexual assault can be painful and interfere with a survivor’s quality of life. If you experienced sexual assault, you can seek help by visiting a sexual assault resource center, speaking to a mental health professional, or joining a support group.
If you wish to pursue civil or criminal charges against the perpetrator of your assault, speak to a sexual assault attorney as soon as possible. Your lawyer can help you understand what your options are, including the damages you can collect in a sexual assault lawsuit for psychological damage. Contact your lawyer to discuss your story and plan your next steps.


Summary
Fermented foods are consumed in diets worldwide and can be an important part of a dietary strategy to prevent and manage cardiometabolic diseases. However, precise associations between the consumption of fermented foods and cardiometabolic health have not been well established. This could be partly due to the difficulty of accurately capturing their intake through self-report dietary assessment methods. This thesis set out to identify food intake biomarkers (FIBs) for the habitual intake of fermented foods, which can act as more objective measures of intake. In addition, several candidate FIBs for dairy foods that were identified from non-targeted, controlled intervention studies needed to be validated under free-living conditions. These aims were achieved using data from a free-living cohort in the Netherlands (NQplus). Alongside, associations between fermented food and dairy food intake, biomarkers, and cardiometabolic factors were explored, revealing the diverse metabolic effects of these foods.


Under the recent Bill to amend the Companies Ordinance (Cap. 622), the government is adding the new requirement for companies to keep a Significant Controllers Register.
All Hong Kong incorporated companies with or without share structure, except listed companies and exempt companies, will need to maintain this new register. The main purpose of this Bill is to meet Hong Kong’s obligations to combat money laundering and terrorist financing by showing who has the significant control of a suspected company. The register must be kept in the English or Chinese language. Even your company has no significant controller, you still need to maintain this register open for inspection by law enforcement officers. Law enforcement officers include but not limited to officers of the following agencies: Companies Registry (C/R), Customs and Excise Department, Monetary Authority, Police Force, Immigration Department, Inland Revenue Department (IRD), Insurance Authority, Independent Commission Against Corruption (ICAC), and Securities and Futures Commission.
Please refer to our Technical Support Bulletin (August 2017 Issue) for law interpretation and implementation detail. If you have not yet received the TSB please call us at 2521-3110.
Details of Who is a Significant Controller? What needs to be recorded on a Significant Controllers Register? What is the proper procedure when you just find out there is a Significant Controller? What if there is no Significant Controller? What if there is an unidentified Significant Controller? What if you cannot confirm the particulars of that identified Significant Controller? What if the company is currently trying to obtain the required information? What if a matter noted in its significant controllers’ register is no longer true? What is the penalty for non-compliance? CSA Expert update.


global study co-led by NUI Galway into causes of stroke has found that one in 11 survivors experienced a period of anger or upset in the one hour leading up to it. One in 20 patients had engaged in heavy physical exertion.
The suspected triggers have been identified as part of the global INTERSTROKE study – the largest research project of its kind, which analysed 13,462 cases of acute stroke, involving patients with a range of ethnic backgrounds in 32 countries, including Ireland.
Stroke prevention is a priority for physicians, and despite advances it remains difficult to predict when a stroke will occur. Many studies have focused on medium to long-term exposures, such as hypertension, obesity or smoking. Our study aimed to look at acute exposures that may act as triggers.
The research analysed patterns in patients who suffered ischemic stroke – the most common type of stroke, which occurs when a blood clot blocks or narrows an artery leading to the brain, and also intracerebral haemorrhage – which is less common and involves bleeding within the brain tissue itself.
The research has been published in the European Heart Journal.
Release date: 03 December 2021
Source: National University of Ireland Galway


On Wednesday, May 4, 2021, a grandmother was killed in a hit and run by a gray pickup truck. About 24 hours later, Las Vegas police arrested Lemar Gant on suspicion of the hit and run and charged him with failing to stop at the scene of an accident. This tragic accident highlights the ongoing need for improved pedestrian safety and awareness in Las Vegas.
Las Vegas remains one of the most dangerous cities for pedestrians, cyclists, and motorcyclists. According to the National Highway Traffic Safety Administration (NHTSA), Las Vegas is 15th out of 34 large U.S. Cities for fatal pedestrian accidents. Approximately 2.51 pedestrians are killed for every 100,000 residents. Las Vegas trails much larger cities such as Fort Worth, Los Angeles, and Detroit. Moreover, the state government declared pedestrian fatalities an epidemic when pedestrian accidents surged 50%.
Pedestrian Fatalities in Las Vegas
According to NHTSA, pedestrian fatalities account for 25% of all traffic-related deaths in Las Vegas. Further, according to NHTSA, the most dangerous streets in Vegas aren’t on or near the Strip but are instead on major boulevards further from the Strip. These other boulevards see more fatalities despite the Strip having far more pedestrians and cars than any other street in Las Vegas.
Causes of Pedestrian Accidents
According to an NHTSA report, most pedestrian accidents involve one or more of the following factors:
Jaywalking, Inattention, Alcohol, Drugs, and Pedestrians are not watching for turning vehicles.
NHTSA found that approximately 10% of all pedestrian fatalities can be linked to the pedestrian’s inattention. Additionally, nationwide distracted walking is an increasing hazard, with fatalities linked to a 2% increase in pedestrian deaths.
Moreover, an increasing number of traffic accidents in Vegas is linked to marijuana use. Since the legalization of marijuana, pedestrians and drivers are more likely to be under the influence of this drug and become involved in accidents.
Pedestrian Awareness
The Nevada Department of Transportation (DOT) warns pedestrians to stay alert. While pedestrians have the right of way in most scenarios, pedestrians are the ones who will bear the brunt of injury or death if they are hit by a car. As a result, the DOT is undertaking more safety improvements in Las Vegas, including enhanced lighting, S-islands, pedestrian medians, and rapid flashing beacons to alert drivers and pedestrians.


Abstract
In 2014, High School Curriculum Guideline Adjustment has become a national controversial issue with furious legal and historical debates. The issues that have emerged include the content of curriculum, procedures for curriculum decision-making, and the authority of curriculum decision-making. Rather than focusing on the legal and historical dimensions of the debates, this paper focuses on the political dimension of curriculum decision using Amy Gutmann’s Democratic Education Theory. Under the assumption of conscious social reproduction and following the rule of non-discrimination and non-repression, this paper discusses how political disagreement about curriculum should be handled. Cultivating the ability of public deliberation and public participation is critical for a democratic society and should be included in education.
Keywords A. Gutmann Curriculum decision-making Democratic education Politics of education Public deliberation ASJC Scopus subject areas Education