Abstract
Federal regulations require refuge alternatives (RAs) to be installed in underground coal mines. RAs provide miners safe shelter from life-threatening environments during a mine emergency when escape is not possible. Built-in-place (BIP) RAs require ventilation systems that supply breathable air to occupants. Relief valves provide critical functions to the ventilation system by limiting pressure within the RA, allowing ventilation air to exit while preventing contamination ingress, and protecting occupants from external pressure due to mine explosions. As such, relief valves for BIP RAs must be developed and tested to ensure pressure relief, adequate airflow, and the ability to withstand a 103-kPa (15-psi) blast overpressure with a duration of 0.2 seconds.
The National Institute for Occupational Safety and Health (NIOSH) has published research on relief valve opening pressures and airflow rates. However, the ability of RA relief valves to withstand a survivable mine explosion must be demonstrated. As such, NIOSH researchers tested the ability of RA relief valves to withstand overpressure representative of a survivable mine explosion. For this, seven relief valves were subjected to 103-kPa (15-psi) target overpressure waveforms, produced using methane-air explosions within a fixed-volume enclosure. All seven relief valves survived the overpressure testing, maintained normal performance, and did not incur any critical component deformation. One instance of valve leakage was observed during the tests.
This paper presents the methodology and results of testing the ability of RA relief valves to withstand a survivable mine explosion. Information in this publication can be used for evaluating relief valve design and determining parameters critical to their ability to reliably withstand a survivable mine explosion and protect RA occupants. Research presented in this paper is applicable to testing and improving RA designs for underground coal mines, and could also be extended to similar applications and industries involving explosion testing.


By using techniques such as slow motion and motion graphics, food producers can create engaging and visually appealing videos that showcase their products in a new light. This trend has led to a boom in food industry video production, with many companies now hiring videographers and filmmakers to create content for their websites and social media channels.
While some argue that this trend is superficial and does not really add anything to the quality of the food itself, there is no denying that it is an effective way of marketing products and reaching new audiences.


Abstract
In this paper, we present a non-invasive assay using scanning electrochemical microscopy (SECM) for detecting osteogenic differentiation at physiological conditions (pH 7.5) on arrays of C2C12 microtissues. Upon exposure to bone morphogenic protein 2 (BMP-2), C2C12 microtissues differentiate and express alkaline phosphatase (ALP), which is indirectly detected through an enzymatic assay producing an electroactive species. The latter is detected using SECM by scanning at constant height over live microtissues at physiological pH (7.5) as well as more alkaline pH (8.5). As a control, expression of ALP is confirmed using a standard colorimetric assay. Detecting differentiation on live samples at physiological conditions represents a significant improvement for continuous monitoring of tissue differentiation or further use of the microtissues for, e.g., regenerative medicine.
Keywords EWI-25472 IR-93335 METIS-309757


Breastfeeding is more than a child suckling at the breast.
The current international breastfeeding symbol only shows a child nursing at the breast.
The Universal Breastfeeding Symbol recognizes that there are more ways to chest/breastfeed. For example, research* shows that the vast majority of breastfeeders express milk at some point, so why doesn’t the current symbol include this? Why might a lactating person not nurse at the chest or breast?
They might be:
Temporarily separated from their child, for example at work, at school, or on a trip (or expressing milk in anticipation of being away from their child). E xclusively pumpingbecause of issues with nursing, their child is in the NICU, they were a gestational surrogate, or they simply chose to. Maintaining their milk supplywhile working on getting their child to latch. Relieving or stimulating an oversupplyso as to store or donate milk. Stimulating more milk supplyin the case of undersupply. Inducing lactationprior to welcoming a non-gestational child into their family or to restart human milk feeding of their own child. Permanently separated from their child, for example due to a custody dispute, incarceration, or because they are unable to care for their child. Expressing their milk after the loss of a child, also known as grief pumping. Taking medication that is unsafefor their child and need to express their milk until it is safe again. The Universal Breastfeeding Symbol
This led me to developing the
Universal Breastfeeding Symbol, which depicts both nursing and the most common form of milk expression, a breast pump.
I recognize that this symbol only includes two ways to feed.
Head to www.breastfeedingsymbols.com for other symbols, such as exclusive pumping, grief pumping, and tube feeding.
* 98% of all respondents had expressed milk: Clemons, S. N., & Amir, L. H. (2010). Breastfeeding women’s experience of expressing: A descriptive study.
Journal of Human Lactation, 26(3), 258–265. http://doi.org/10.1177/0890334410371209
85% of respondents had expressed milk by 6 months: Johns, H. M., Amir, L. H., McLachlan, H. L., & Forster, D. A. (2016). Breast pump use amongst mothers of healthy term infants in Melbourne, Australia: A prospective cohort study.
Midwifery, 33, 82–89. http://doi.org/10.1016/j.midw.2015.10.009


Abstract This paper examines the impact of social media in developing Arab women’s interest in sports. A survey questionnaire based on the uses and gratification theory was distributed to 411 Arab women from different age groups, education levels, and employment statuses. In analyzing the results to explore the participants’ motivation …Read More »
Abstract: This article tackles the complex struggles faced by Arab women, including multiple layers of invisibility, marginalization and inequality,[1] all of which have significantly worsened during the COVID-19 pandemic. This examination includes a special focus on how and why the “digital divide,” defined as the gap between the technological haves …Read More »


What is a intimacy disorder?
Intimacy Disorders are another way of stating of unhealthy boundaries. Boundaries are the road signs that guide you on the highway of life. Boundaries indicate to self and others when to "yield, stop, do not enter, enter, go with caution, under construction, and so on." So, if boundaries are road signs on the highway of life, how would boundaries look if they are not working, invisible or are not used? Simply, the highway is cluttered with too many signs, not enough signs, or missing signs. Therefore, the security and confidence of a safe highway is not experienced by the driver. So, what is the explanation for you, the driver?
You were not given a driver's education class to experience how to be secure and confident with your signs. Therefore, you may be avoidant of the signs, fearful of the signs, dismissive of the signs, or preoccupied on the signs.
Your thought and question, now, may be - I have been struggling too long. How do I learn and use these boundaries and how can you help me? First, you admit that the struggle is real. You learn to adapt and to survive the fear of insecurity with signs on the highway. With confidence, I believe what has been learned can be unlearned. I can help you gain knowledge about yourself and relationships. I can help you gain an understanding how these unhealthy and insecure boundaries have impacted how you relate with yourself and others. I can provide different ways to see your journey and to empower you on your journey. If you are reading this, you have started the knowledge building and the empowerment already. You can continue the journey by contacting me at 469-708-6387 or email me at rubyjohnsonlcsw@gmail.com TODAY. This road sign reads:


Know Your Rights: Weingarten Rights and Disciplinary Protection
While the 100,000 represented employees of Local 1000 are represented by 10 different bargaining units, include more than 700 different classifications, and are employed at more than 2,000 worksites, we all have at least one thing in common: the strong fundamental protection provided by what’s commonly called your “Weingarten Rights.”
Your Weingarten Rights state that it’s your right to have a representative present during an interview that you reasonably believe could lead to discipline. The right to this kind of representation stems from the 1975 Supreme Court case, NLRB v. J. Weingarten.
If you are ever called into a meeting with your supervisor or manager and believe the meeting or the information gathered in the meeting may result in discipline, you have specific representational rights. These include:
You have the right to have a union steward present. If you want a steward present, you must ask for him or her. If you do not know why your manager wants to meet with you, ask him/her if it is a meeting that could result in discipline. If your manager refuses to allow you to bring a Job Steward, repeat your request in front of a witness. Do not refuse to attend the meeting but respectfully decline to answer questions until your union representative is present. You have the right to speak privately with your Job Steward before and during the meeting. Your Job Steward has the right to play an active role in the meeting—they’re not just a witness. If your manager denies the request for union representation and directs you to answer questions even without your Job Steward present, they are committing an unfair labor practice and the employee has the right to refuse to answer. Any discipline taken under these circumstances could be challenged as improper at PERB. This statement could save your job: If this discussion could in any way lead to my being disciplined or terminated, I respectfully request that my steward be present at the meeting before I answer any questions. Without representation present, I choose not to respond to any questions or statements. How to take action
If you feel these rights have been violated, contact your Local 1000 Job Steward or call the Member Resources Center from 7:00 a.m. – 7:00 p.m. Monday through Friday at 866.471.SEIU (7348).


In its most recent evaluation report on Greece, released on June 9, 2022, the United Nations Committee on the Rights of the Child (UNCRC) has demanded that Greece cease its detention of refugee youth and reform its policies towards refugee children, which violate their rights as per the UN Convention on the Rights of the Child. During the months of April and May, the UNCRC reviewed evidence provided by Still I Rise (SIR) and I HAVE RIGHTS (IHR) that demonstrate human rights violations of children on Samos. SIR and IHR raised specific concerns regarding de facto detention and inhumane living conditions, deficiencies in age and vulnerability assessment procedures, lack of access to asylum, and lack of services.
Thanks partly to the evidence we provided, the UNCRC has officially acknowledged violations of the rights of the child by the Greek government and have confirmed SIR and IHR’s concerns regarding the state of refugee children and Unaccompanied Minors (UAMs). Ultimately, this report supports our advocacy efforts to grant appropriate and legally mandated living conditions, services and access to asylum as per the human rights standards enshrined in the Convention of the Rights of the Child.
UNCRC’s Evaluation of Greece’s Violations
In its Concluding Observations, the UNCRC clearly states that they acknowledge “numerous violations of the rights of asylum-seeking, refugee and migrant children in Greece.” This contradicts the official Greek narrative and is in line with SIR and IHR’s perspective. Within the report, the UNCRC validated all four topics of concern raised by SIR and IHR.
De Facto Detention and Inhumane Living Conditions
The UN’s report clearly acknowledged Greece’s use of “immigration detention of children for identification purposes” and the unfortunate reality of “precarious living conditions in reception centers (RICs) on the Aegean islands.” In line with the concerns of SIR and IHR, which have witnessed and received testimony of people living in prison-like conditions, the Committee pressed the Greek government to “completely ban the placing of children in immigration detention” and to “prioritize the immediate transfer of asylum-seeking children and their families out of detention centres.” Additionally, the Committee headed SIR and IHR’s calls to push the Greek government to provide refugees, asylum seekers, and UAMs with proper accomodation”outside detention” and to “promptly closing[close] “safe zones,” a tool used to further isolate UAMs from other parts of the facility. SIR and IHR arehave been vocal about the deplorable conditions in the Samos CCAC “safe zone,” where UAMs are supervised by untrained personnel and access to particular services, including formal education, is severely limited.
Deficiencies in Age and Vulnerability Assessment Procedures
The Committee’s Concluding Observations also noted the Greek government utilizes a “generalized and inappropriate age determination procedure,” which particularly affects UAMs on Samos. The Committee urged the Greek government to “ensure that the age-determination procedure is…respectful of children’s rights,” and more importantly, to use only in “cases of serious doubt about the claimed age.” As it currently stands, age-determination and vulnerability assessments are often led by untrained and unprepared personnel on Samos, a fact that SIR and IHR communicated in our submission to the UN.
Lack of Access to Asylum
The report additionally notes that the asylum reform (Law 4636/2019), otherwise known as the Internal Protection Alternative (IPA), lacks the “safeguards to protect children’s rights.” The Committee called on the Greek government to review its legal obligations to “ensure that…appropriate safeguards in asylum proceedings are provided for children, including unaccompanied and separated children…” and that “children are exempt from the accelerated border asylum procedures.” On Samos, SIR and IHR have collected testimonies which suggest children are not adequately protected by the current law and are wrongly treated by the authorities.
Lack of Services
Regarding the lack of services, including access to legal assistance, education, healthcare, and other social services, the Committee largely disapproved of Greece’s present performance. The Committee urged Greece to “ensure access to free legal aid…essential services, including food and hygiene…[and] healthcare,” to “address the barriers hindering access to education,” and to “provide all possible facilities, services and protection to all refugees on an equal basis with Ukrainian refugees.” The Committee’s recommendations cover a wide range of services that should legally be provided to refugee youth and UAMs. Yet as SIR and IHR indicated in our submission, the Greek government fails to provide the services it is obligated to do. On Samos, the conditions of the prison-like camp create severe mental health challenges for the people living there. At the same time, limited, and in some cases, zero access to essential services abandons those in need. This dynamic of isolation, enclosure, and withholding essential services from refugees and asylum-seekers is a truly cruel practice that must end.
From Law to Practice
Thanks in part to the evidence provided by SIR and IHR, the UNCRC has officially recognized human rights violations against refugee and UAM children and pressed the Greek government to uphold its legal responsibilities. However, the UNCRC’s Concluding Observations will not impact their present situation unless the Greek government change its current practices. We thus continue our fight, now with backing from the UNCRC, in pushing the Greek government to provide refugees and asylum-seekers with the rights and services they are legally guaranteed.
Relevant Articles:


Abstract:
We tested the hypothesis that increased hypoxia in Lake Victoria provides a refugium for the cyprinid dagaa (Rastrineobola argentea) against hypoxia-sensitive Nile perch (Lates niloticus). 2. Hypoxia in the main habitat of dagaa was rare during 1979–80, but lasted 3–5 months in 1987 and 1988, during which time adult dagaa spent the day just above the oxycline instead of near the bottom. 3. Dissolved oxygen concentrations in the layer just above the oxycline were not critical for Nile perch, but a mass kill of this species following a sudden upwelling of hypoxic water suggested that oxycline-dwelling is risky. 4. Our data suggest no difference between dagaa and Nile perch in the level at which dissolved oxygen starts to limit their vertical distribution in the water column, but dagaa seems to be even more sensitive to extreme hypoxia (B1–2 mg O2 L1) than Nile perch. 5. We argue that oxycline-dwelling dagaa are not seeking a predation refugium but that they are limited by low oxygen levels in reaching their feeding areas near the bottom.


Real-Time Network Operations Research Project Full Title: Lina Sela Principal Investigator(s): Rapid urbanization, depleting water resources and infrastructure deterioration pose new challenges in maintaining modern infrastructure. Resilient urban infrastructure, including water distribution systems, are crucial for societal well-being. Smart infrastructure operation driven by sensing and actuation technologies are one of the primary solutions toward resilient urban systems. This work focuses on: Full Abstract: Design:Sensor placement configurations for network-wide coverage and identification of pipe failure locations given budget constraints. Develop computational efficient algorithms scalable to large-scale networks. Sela Perelman, W. Abbas, X. Koutsoukos, and S. Amin. “Minimum test cover approach for fault location identification in flow networks.” Automatica, 72, pp. 166-177, 2016. Monitoring:Real-time sensor network for continuous monitoring of water pressure to detect transients caused by fluctuations in demands and system routine operations. This is an ongoing project to establish a test-bed to involve the real worldin the process of developing algorithms. Operation:Combining real-time data acquired from the sensor networks with modeling and machine-learning tools for system state estimation, pipe failure detection and prediction.


A Roth IRA calculator is a great way to estimate your potential savings and returns. You can use it to determine whether or not the Roth IRA is right for you. You can also use it to compare different
types of retirement account. Knowing which option will offer you the most significant benefit can make the decision easier. However, you should always consult a financial professional before deciding.
Roth IRA contribution limits are based on your modified adjusted gross income. However, certain income levels allow you to make partial contributions to your Roth IRA. Traditional IRAs do not have income limits and may be deductible. However, there is an excise tax on excess contributions.
If you have made excess contributions, you must withdraw them before the end of the year to avoid paying tax penalties. You must also withdraw the earnings from your IRA within six months, or you will be subject to a 6% penalty. You can work with a tax professional to ensure you don’t exceed these limits. If you are uncertain whether you can meet the Roth IRA contribution limits, check the IRS website.
For investors 50 and over, the last day to make contributions is April 15 of the following year. For example, in 2021, the maximum contribution limit is $7,000, while investors under 50 can make $6,000 this year. After that, if you don’t meet these limits, you have until April 15, 2023, to make maximum contributions.
The Required Minimum Distribution (RMD) is the amount of money a person must take out of an IRA account each year. This amount is determined by taking the account balance divided by your age and your spouse’s age. Most people use the IRS’ Joint Life and Uniform Life Table to calculate their RMD. If you are younger than your spouse, your RMD will be lower.
You may also defer RMDs until you reach retirement age. Check with your employer to find out if your employer will allow you to do this. The IRS’s website has the latest tables and calculation worksheets. These tables have been updated to reflect changes in life expectancy.
RMDs are taxable income calculated at the individual federal income tax rate. They may also be subject to state and local taxes. As a result, you may need to consider after-tax contributions to calculate the required amount. While after-tax contributions may reduce your taxable income, you may be pushed into a higher tax bracket and have to pay more for
Social Security.
There are several ways to reduce the tax on a Roth conversion. One strategy is to utilize tax-loss harvesting, which means you can offset gains with losses to lower your regular income. Another strategy is to make sizable charitable gifts during the year of conversion. This strategy can reduce the tax on a Roth conversion by a significant amount.
Converting your IRA into a Roth is an intelligent way to protect your retirement money. However, it can be a complex process. You must carefully consider your tax situation and consult a tax advisor before making any big decisions. The IRS has specific rules for calculating your taxes.
Before you decide to convert, you must understand the tax implications of the move. For example, if you’re moving to a higher-tax state, you must consider your state taxes. It would help if you also determined how much traditional IRA you need to convert.
Roth IRAs are retirement accounts that allow you to invest at tax-free rates. Withdrawals from a Roth IRA are tax-free because the IRS has already paid your tax on your contributions. In addition, you do not have to withdraw money every year like you would with a
traditional IRA. However, there are some restrictions and limitations regarding Roth IRA withdrawals.
Tax-free growth may be a significant benefit if you are still working and planning to retire. While you can’t take tax deductions, your earnings grow tax-free, meaning you will not pay taxes until you withdraw them. And because withdrawals from your Roth IRA will be tax-free, you may have more time to invest than you thought.
A Roth IRA is a great way to save for retirement because you’ll pay lower taxes now and avoid higher taxes later. You can withdraw your contributions without paying taxes, and your earnings will grow tax-free. And because you’re not required to take distributions, you can make contributions whenever possible. You can even fund your higher education.


During this past week, I once again grew to appreciate the continued good service of American Express. I lost an American Express credit card while on a trip to Boston. For a moment I panicked, but I was quickly reassured by American Express that all will be okay. The AE operator assured me that my old card would be cancelled, I would not be held responsible for any charges made by the possible finder of the card, and I would have a new card the next day. They even asked if I needed any cash. And, yes, the card was delivered by UPS the next day.
This is what you call “good service” and good execution by a company to fulfill the customer’s expectations. This is their differentiation value, or “DV,” from other credit card companies. It is the reason I continue to believe in their service and reputation, and keep renewing my card with them.
Customer loyalty also comes in different sizes and ways. I am a “Starbucks snob,” I guess. The reason I enjoy Starbucks is that I get a consistent good cup of coffee. I also like walking into my Starbucks and hearing Heidi, the store manager, tell me good morning and remember what my drink order is—a triple latte, skinny, no foam with an equal on bottom. She even remembers my name. Good service and customer recognition: that is why I go out of my way to visit “THIS Starbucks” store versus another, or their competition.
This is what small establishments often do well: they successfully compete by delivering good customer service, securing a loyal customer base. The integration of good customer service training in our operations, along with our corporate culture, translates into customer loyalty. This is how you retain clients and customers. There is parity between good service and the resulting loyal customers.


For those of you who have had an H. pylori infection, you remember the ulcers, gastric reflux, bloating, nausea or a deep gnawing pain in your stomach that sent you running to the doctor. But did you know that these bacteria may also cause frequent belching, reduced appetite, unexplained weight loss, joint or muscle pain, chronic fatigue, thyroid issues, and psychological symptoms? H. pylori can put you in a brain fog where you feel like you can’t figure anything out,


This collection provides an introduction to the field of neuroscience, exploring five major branches of study: neurophysiology; neuroanatomy; cell and molecular neuroscience; behavioral neuroscience; and developmental neuroscience.
This collection introduces the field of developmental biology and cover five areas: developmental genetics; molecular developmental biology; stem cell biology; organogenesis; and aging and regeneration.
This collection focuses on genetics and incorporates five broad subdisciplines: the genetics of individuals and populations; genetics and disease; gene expression; epigenetics; and genetic engineering.
This collection provides a glimpse into the field of cell biology and profiles five important cellular phenomena: cell division; motility; endocytosis and exocytosis; metabolism; and cell death.
This collection covers many staple techniques of immunology labs, including the labeling and sorting of immune cells. It also demonstrates proliferation methods for immune cells and antibodies, as well as common assays for immune activity including ELISA. Finally, it demonstrates staining and imaging of immune tissue and cell samples.
This collection demonstrates the key tools of microbiological investigation, including proper sterile technique and plating, how to use selective media and enrich samples, and culturing methods for mixed or pure samples. Additionally, it looks at common methods for identifying microbial isolates, as well as procedures for the genetic manipulation of bacteria.


Patient Panels
This should be between 250-300 words.
Patient panels are developed by individuals with guidance from their organization’s internal experts. In some settings, such as government-run facilities, patient panel structure is more strictly directed.
Briefly explain how a patient panel is constructed (for example, in a free-standing primary care clinic). Who is involved in the process? Are internal policies involved?
Should patient panel size and diversity be regulated by the government? Explain your position.
Please be sure to validate your opinions and ideas with citations and references in APA format.


Abstract Abstract
The study was designed to investigate the quantity and reasons of wastage of blood products. This was an observational study conducted from February 2018 to February 2019 at the National Institute of Blood Disease and Bone Marrow Transplantation (NIBD and BMT), PECHS campus. The study was approved by the institutional review board. Wastage and reasons of wastage for all the blood products were evaluated. Frequencies were calculated by using SPSS version 23.0. A total of 2,880 bags of blood products were available, including 960 each of platelets, packed red cells and fresh frozen plasma. The overall wastage rate was 3.5%. Packed red cells and platelets were fully consumed, yet shortage of supply was observed. However, highest wastage was observed in fresh frozen plasma i.e. 102 bags. Expiry of unused products 60 (59%) followed by broken bags 30 (29%) were two common modes of wastage.
Continuous...


CCs (cubic centimetres) and mL (millilitres) are both volume units that have the same value but are derived from distinct base units. A volume expressed in CCs can be translated to mL by multiplying by 1, as 1 CC equals 1 mL.
The centimetre is exactly 1 percent of a metre and is derived from the metre. A cubic centimetre represents precisely 0.0001% of a cubic metre. The millilitre is derived from the litre, which, unlike the metre, is a volume unit. A millilitre is exactly 0.001% of a litre. Before using a ruler to measure a particular volume of liquid, it is most practical to convert the volume to CCs or cubic metres.


Molecular dynamics simulation has become a powerful tool for studying biochemical properties. At the heart of these calculations is the potential energy function that describes intermolecular interactions in the system, and often it is the accuracy of the potential energy surface that determines the reliability of simulation results. The current...
Creator:
Gao, Jiali (University of Minnesota, Twin Cities)
Created:
2009-01-15
Contributed By:
University of Minnesota, Institute for Mathematics and its Applications.


Rising inflation and interest rates have spurred the IRS to make record increases in retirement plan contribution and compensation limits for 2023.
These changes are outlined in IRS Notice 2022-55, but here are some of the highlights:
Elective annual deferral limits for most employer-sponsored retirement plans will rise from $20,500 to $22,500, the largest increase in decades. Annual catch-up contributions for 401(k), 403(b) and similar defined contribution plans will rise from $6,500 to $7,500. The annual aggregate contribution limit (the combined total of both employee contributions and employer matching and profit-sharing contributions) for defined contribution plans is increasing from $61,000 to $66,000. Annual contribution limits for Traditional and Roth IRAs will rise from $6,000 to $6,500. Catch-up contributions, currently $1,000 per year, are not increasing.
The table below summarizes the key changes for 2023.
1 Employee deferrals to all 401(k) and 403(b) plans must be aggregated for purposes of this limit. 2 Contributors must be age 50 or older during the calendar year. 3 All compensation from a single employer (including all members of a controlled group) must be aggregated for purposes of this limit. This material has been provided for general informational purposes only and does not constitute either tax, legal or investment advice. Retirement savers should consult a tax preparer, attorney or financial advisor to discuss their specific situation.
###
Michael Flaherty is a financial advisor located at Canby Financial Advisors, 161 Worcester Road, Framingham, MA 01701. He offers securities and advisory services as an Investment Adviser Representative of Commonwealth Financial Network®, Member FINRA/SIPC, a Registered Investment Adviser. He can be reached at 508.598.1082 or mflaherty@canbyfinancial.com
© 2022 Canby Financial Advisors and Commonwealth Financial Network.


Announcing: CancerIQ for Preventive Care CancerIQ is enabling primary care providers to assess every patient’s comprehensive cancer risk and navigate them through hyper-personalized cancer prevention pathways. We're expanding beyond hereditary cancers to reduce risk across all types of cancer, allowing health systems to realize the clinical and financial benefits of risk-based cancer screening at the population level. Improving outcomes at the population level
Each person’s cancer risk is based on a unique combination of factors, including family history, lifestyle choices and screening adherence. But the current healthcare system relies on a one-size-fits-all, age-driven approach to cancer screening and prevention — meaning many patients receive late-stage diagnoses that could have been detected earlier or avoided altogether.
“Every patient who walks through the door deserves a personalized, evidence-based action plan to ensure they get the right care, at the right time, to reduce their cancer risk. And primary care providers deserve to have a platform that enables them to make that a reality.”
Live at HLTH on The Newsroom Stage CancerIQ CEO invites health systems to join 7 others in national PREVENT initiative to measure the impact of risk-based cancer screening at scale The expanded platform Personalized risk assessments
Our expanded platform conducts personalized risk assessments using patient-collected data, EHR data, & the latest risk models and oncology guidelines.
Risk stratification
The platform’s risk stratification and recommendation engine make it easy for primary care providers to segment all patients by risk level across the population.
Automated documentation
Automated documentation and test ordering tools are built directly into the workflow to streamline and guide shared decision making and patient activation at the point of care.
Patient education
Engage and educate patients, and generate care plan recommendations with included patient letters.
Initial clinical findings
An initial implementation of CancerIQ’s expanded platform at three health systems found clinical and financial benefits. Of assessed patients, the platform identified 36% needed hereditary cancer testing, 5% needed a low-dose lung CT, and 16% needed a colonoscopy. Without CancerIQ, these patients may have missed out on these tests that can help prevent a late-stage cancer diagnosis.
36% OF PATIENTS
needed hereditary cancer screening
5% OF PATIENTS
needed low-dose lung CT screening
16% OF PATIENTS
needed colorectal cancer screening At HLTH, CancerIQ extended the invitation to forward-thinking hospitals and health systems that want to reduce cancer risk and improve outcomes at the population level.
CancerIQ is conducting the PREVENT initiative to continue to measure the clinical and financial impact of its expanded platform across more diverse clinical settings. PREVENT stands for patient risk evaluation, education, navigation and testing). Seven health systems from across the country, serving urban and rural patient populations, have already signed on to participate.


CMBG3 is committed to supporting our community and giving back through out CMBG3 Cares program, an initiative that ensures that every month, our team members have a way to volunteer their time to our community or make a contribution in some way to those in need. Every month, CMBG3 Cares chooses a “theme” by which to focus our charitable and community initiatives.
In March 2021, the Cares theme was children in need. This year, we chose to focus our efforts on supporting charities that support children placed into the foster care system through no fault of their own. In California, our team identified the Orangewood Foundation, an organization that works one-on-one with youth transitioning to adult life to help them identify their own strengths, attributes, and aptitudes to empower them to overcome their challenges and reach their greatest potential. The organization works with youth in four critical areas: health & wellness, housing, life skills & employment, and education. The firm made a financial contribution to Orangewood Foundation that will help their efforts supporting children in the foster system transition as they age out.
Similarly, in Boston, the firm supported Comfort Cases, which aims to support the nearly 437,500 children that find themselves on a daily basis in the foster care system in the United States. They do so by recognizing that many children are removed from dangerous home situations so hastily that they are removed from their home with only the clothes on their backs or a trashbag with which they can hastily pack a few essential items. Comfort Cases steps in to provide children in foster care their own personal duffel bag or backpack with which they can store and carry their personal belongings, or Comfort Cares will provide children in need with a duffel bag or backpack full of essential items, such as pajamas, a set of clothes, toothbrushes, small toys, or a warm blanket.
If you would like more information about our community and charitable giving programs, please contact John Gardella (jgardella@cmbg3.com), or visit us at our CMBG3 Cares page.


You're better off paying out of pocket (you sort of already are...)
Coffee is widely known for magically increasing focus and energy, but that's not the case for all.
This star has always been charitable, but now he's dedicating time to supporting the troops.
You may want to skip over these next time you're at the grocery store, per the advice of dietitians.
Researchers found that regularly drinking caffeinated coffee might minimize the risk of type 2 diabetes.
It certainly wasn't the chain we were expecting.
A dirty coffee maker may become a home for bacteria, yeast, or mold.
Ending my relationship with caffeine was one of the best decisions I ever made.
You won't even have to leave your car!
Making these small shifts first thing in the morning can help you manage your weight loss goals.
Now, you'll have the best and latest food and healthy eating news right in your inbox—every single day


Do insurers have blind spots when it comes to protecting their data and networks? Unfortunately, the answer is a resounding yes. In fact, many insurers are actively ignoring significant risk due to a lack of holistic security visibility, waning internal expertise, and real-time, accessible and actionable tools.
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Yesterday, the United States Supreme Court announced that it would hear legal challenges to Harvard’s admissions process, which currently considers race as one factor among many. The Harvard Black Men’s Forum supports Harvard’s admissions process and strongly believes in the importance of creating a diverse campus community. This lawsuit threatens to undermine efforts at Harvard and universities across the country to diversify their student populations and increase access to institutions of higher learning. As supported by multiple legal victories in lower courts, Harvard’s admissions process is constitutional and works to create a diverse academic and social experience for all students. In closing, the Harvard Black Men’s Forum urges the Supreme Court to support Harvard’s admission process.


Hello, I am Priom Patel, proud owner of Primrose School of East Brunswick. My husband, Nilesh Patel, and I are long-time residents of New Jersey and parents of two beautiful children who are our pride and joy.
As parents, we naturally wanted the best for our children while looking for child care options during their early developmental years. However, we were often left feeling challenged when we realized that most of them did not meet our expectations. So when life offered us an opportunity to contribute to this arena and fulfill our dream of creating an establishment that offered a safe, healthy and a happy environment for children, we decided to partner with Primrose, the Leader in Early Education and Care.
What impressed us the most about Primrose was their vision for innovation within childcare and advocacy for providing premier early education. We value the importance of education and we understand that the first 5 years of life are crucial for healthy brain development. Primrose’s research-informed and time tested curriculum is geared in that direction. Primrose has a strong sense of collaboration that interlocks within the school, families and the community to help children build a strong educational foundation for life while providing an environment that ensures their safety. The exclusive early learning approach from Primrose, balances purposeful play with nurturing guidance from teachers to encourage curiosity, creativity, confidence and compassion. We deliver much more than just a curriculum; it’s a life-changing early learning experience for children and their families.
We are honored and thrilled to bring the Primrose School experience to the vibrant, diverse and family-friendly community of East Brunswick and surrounding areas, and thereby make a positive impact in the lives of others. Our goal is to ensure all families have peace of mind knowing that their children are receiving high-quality early education and care in a happy, healthy and safe environment.
I have over 15 years of corporate experience in HR with expertise in building strong relationships based on trust, good understanding and integrity. I am fully committed to serve as the ‘Chief Caring Officer’ of the school.
Looking forward to meet you and welcome you to our Primrose family!


The Federal Trade Commission is facing mounting pressure to block Amazon’s proposed $1.65 billion purchase of iRobot, the company behind Roomba autonomous vacuums.
In a letter to FTC Chair Lina Khan on Thursday, a group of Democratic lawmakers argued that the proposed merger would unfairly bolster Amazon’s dominance in the smart home market by acquiring one of the company’s leading competitors. They also criticized Amazon’s data privacy and security practices following past acquisitions of companies like Ring, including data sharing partnerships with over 600 law enforcement agencies across the country.
“iRobot is a powerful market incumbent, and Amazon, given its vast resources, history of producing smart vacuums… and powerful platform, is an extraordinarily significant ‘potential entrant’ into the market,” the lawmakers wrote on Thursday.
“Amazon’s ability to acquire iRobot would cause substantially less competition”
Sen. Elizabeth Warren (D-MA) led Thursday’s letter along with four other House lawmakers, including Rep. Pramila Jayapal (D-WA), who represents thousands of Amazon workers in Seattle.
Over the last two years, antitrust enforcers in the US and EU have launched a series of investigations into Amazon and its products. Most recently,
Politico reported that the FTC was investigating the company’s plans to enter the healthcare market by purchasing One Medical for nearly $4 billion. Earlier this year, Amazon finalized its purchase of MGM for $8.45 billion, but it’s unclear if the agency plans to further review the deal as of publication.
Earlier this month,
The Wall Street Journal reported that antitrust enforcers at the FTC were already reviewing the proposed deal. iRobot confirmed in recent securities filings that the FTC formally requested any documents outlining the proposed purpose and scope of the merger.
“Given Amazon’s record of infringing on consumers’ privacy, and their ongoing history of anticompetitive mergers to increase their monopoly power, the FTC should use its authority to oppose the Amazon – iRobot transaction,” the lawmakers wrote.
These investigations would be led by Chair Khan, whose criticisms of Amazon’s market power led to her rise in prominence. Khan published a legal paper in 2017 arguing that the federal government may need to pass new antitrust statutes to properly address the market dominance of online tech platforms like Amazon.


Title: Cis-acting gene regulationby long noncoding RNAs.
Abstract:
It is now clear that many intergenic regions in eukaryoticgenomes give rise to a range of processed and regulated transcripts that do notappear to code for functional proteins. A subset of these are long (>200nt), capped, and polyadenylated RNAs transcribed by RNA polymerase II andcollectively called long noncoding RNAs (lncRNAs). The recent estimates arethat the human genome may have >50,000 distinct lncRNA-producing loci, manyof which show tissue-specific activity and dysregulation in human disease,including cancer and neurodegeneration.
Giventhe growing number of lncRNAs implicated in human disease or required forproper development, fundamental questions that need to be addressed are: WhichlncRNAs are functional? How is functional information encoded in the lncRNAsequence? Is this information interpreted in the context of the mature or thenascent RNA? What are the identities and functional roles of specific sequencedomains within lncRNA genes? These are challenging questions, primarilybecause of the substantial heterogeneity in mechanisms utilized by lncRNAs andthe current paucity of lncRNAs with well-understood mechanisms. We are tacklingthese questions by combination of experimental methods with a focus on lncRNAfunctions in early cell fate decisions and computational methods focused onlncRNA evolution. I will describe our efforts to decode conserved combinationsof short functional sequence elements in lncRNAs, with a particular focus onthe Chaserr/Chd2 and Silc1/Sox11 pathways.
Host: Sagi Levy


Much has been written about terroir—about conveying a sense of place in our food and drink—and perhaps no beer ingredient can do that as palpably as yeast can.
Locally grown malt and hops can reflect their soil and weather, but they are also just local versions of the same varieties grown elsewhere—like cover bands riffing on widely popular tunes. Yeast, on the other hand, have evolved over millennia to the local flora. They are unique to their home environment; they represent original music.
Here are a few ways that breweries are creatively applying these yeasts, often in unexpected ways, along with some pros and cons to consider in your own brewery.


Animals possess the ability to effortlessly and precisely time their actions even though information received from the world is often ambiguous, is corrupted by the influence of noise and is inadvertently transformed as it traverses through neural circuitry. With such uncertainty pervading through our nervous systems, we could expect that much of human and animal behavior relies on inference that incorporates an important additional source of information, prior knowledge of the environment. These concepts have long been studied under the framework of Bayesian inference with substantial corroboration over the last decade that human time perception is consistent with such models. However, we know little about the neural mechanisms that enable Bayesian signatures to emerge in temporal perception. I will present our work on three facets of this problem, how Bayesian estimates are encoded in neural populations, how these estimates are used to generate time intervals and how prior knowledge for these tasks is acquired and optimized by neural circuits. We trained monkeys to perform an interval reproduction task and found their behavior to be consistent with Bayesian inference. Using insights from electrophysiology and in silico models, we propose a mechanism by which cortical populations encode Bayesian estimates and utilize them to generate time intervals. In the second part of my talk, I will present a circuit model for how temporal priors can be acquired by cerebellar machinery leading to estimates consistent with Bayesian theory. Based on electrophysiology and anatomy experiments in rodents, I will provide some support for this model. Overall, these findings attempt to bridge insights from normative frameworks of Bayesian inference with potential neural implementations for the acquisition, estimation and production of timing behaviours.


Hypertrophic cardiomyopathy (HCM), a disease in which the heart muscle becomes abnormally thick, is the most common form of acquired heart disease in cats. Unfortunately, cats with HCM are predisposed to feline arterial thromboembolism (FATE), where abnormal blood clot formation obstructs blood flow to parts of the body. Cats with HCM and FATE usually have poor blood flow to their hind legs, which results in paralysis and severe pain. These cats are often euthanized due to poor quality of life and limited treatment options. Despite the clinical significance of FATE associated with HCM, the underlying factors that predispose cats with HCM to FATE are poorly understood.
The primary aim of this proposed study is to determine whether cats with HCM have evidence of hypercoagulability, which is the tendency for blood to clot excessively. Hypercoagulability will be determined using a blood test called thromboelastography (TEG). A secondary aim is to determine whether cats with more advanced HCM that have heart chamber enlargement have similar TEG parameters as cats with HCM that do not have heart chamber enlargement. These findings can significantly impact diagnosis, treatment, and prevention of FATE.
(Ricky Fund)


An allergic reaction to cocoa is considered rare. In case a reaction arises after consuming cocoa or other related products, it might be a reaction to another ingredient in the product.
What are the possible culprits?
If the cacao bean is ground into powder form, it is exposed to the surfaces and other substances. The equipment might be utilized to process other products and the powder might be mixed with sweeteners and preservatives before added to a chocolate product.
The conventional chocolate bars include not only cacao beans, but other ingredients such as milk, sugar, nuts, artificial sweeteners, soy, wheat, caffeine and corn syrup. An individual with gluten or lactose intolerance might react to the wheat or milk while those with nut allergy might react to the peanut oil or peanut bits. In some cases, chocolate might also include nickel which can trigger skin reactions in some individuals.
What are the signs?
The symptoms often linked with allergies to cocoa or related products include:
Hives Headaches Heartburn Rectal itching Confusion Difficulty breathing
In severe cases, exposure to cocoa can trigger anaphylaxis or a severe reaction with symptoms such as confusion, shortness of breath, chest pain, rapid drop in the blood pressure, dizziness, nausea, heart palpitations, diarrhea and loss of consciousness. If these symptoms are present, seek emergency care help right away.
Management
If an individual is allergic to the cacao beans, he/she must avoid all products that include cocoa. Any cola products must be carefully considered since the antigens might be linked and can trigger similar allergic reactions.
In case an individual is sensitive to a component often mixed with cocoa, carefully read to labels before consumption.
Depending on the seriousness of the allergy, the individual should use a medical alert ID bracelet. If the doctor prescribes epinephrine, the individual should have it on hand always. For skin rashes, the doctor might prescribe antihistamines or lotions while digestive issues might require an antacid or anti-diarrheal drug.


Native American Heritage Month
UI Health celebrates Native American Heritage Month. Native American Heritage Month was declared a monthlong observance in 1990 to celebrate and honor the achievements and numerous contributions that Native Americans have made to our country.
This commemorative month aims to provide a platform for Native and Indigenous people to share their culture, heritage, and experiences.
This year we are recognizing Native American Heritage Month by sharing UIC’s land acknowledgment and highlighting UIC’s educational campaign, “Acknowledge is a verb.”
Land Acknowledgment
We acknowledge that the University of Illinois at Chicago resides on the traditional Territories of the Three Fire Peoples – the Ojibwe, Odawa and Bodewadmi, purchased after two-and-a-half years of open warfare, decades of violent encroachment, and the defeat of a pan-Indian movement to keep settlers out of the Great Lakes region at the Treaty of Chicago in 1821, receiving their final payment before moving westward in 1835. The area was also a site of trade, gathering, and healing for more than a dozen other Native tribes.
Acknowledge is a Verb
However, as we extend our land acknowledgment, we must uphold that “acknowledge” is a verb. Our understanding and appreciation of Native and Indigenous people should not begin or end with the idea that Native Americans are “of the past” or represent any stereotypes. Instead, we must strive to demonstrate that “acknowledge is a verb.”
As part of the University of Illinois Chicago (UIC), UI Health is proud to ensure the importance of the history of the land we occupy and the present Indigenous communities in our area are foundational to our institution. In this spirit, UI Health has adopted the UIC campaign, ‘Acknowledge is a Verb.’
In addition to land acknowledgments, we will collaborate with our Native American and Indigenous patients, staff, faculty, and community members to ensure our policies and practices actively support them.
Confirming our UI Health policies and practices: Create more equitable health and economic opportunities for Native American and Indigenous peoples. Work to eliminate harmful images and historical stereotypes. And recognize Native American and Indigenous people as contributing members of the UI Health and UIC communities.


Past, present and future: positioning the Boards of Appeal of European Union agencies in the European Administration
PhD student: Mrs S. Oosterhuis
Promotors: Prof R.J.G.M. Widdershoven, Mrs Dr M.O. Scholten, M. Gargantini
Duration: 1/3/2021 - 28/2/2025
Abstract:
Over the last couple of decades, the European Union (EU) experienced an increased recourse to a particular kind of administrative bodies: the European agencies. This agentification process has led to a more decentralised and specialised European administration, in which more and more agencies are empowered to adopt binding individual decisions. In these agencies, boards of appeal are established as dispute settlement mechanisms. Although the oldest board of appeal has existed for more than 25 years, the nature of the appeal procedure has always been unclear. Boards of appeal were initially intended as an internal control mechanism within the agency, operating as administrative bodies. At the same time, they possess some judicial features which qualify them as hybrid or quasi-judicial bodies. Their administrative nature has, nevertheless, been emphasised several times by the EU courts. However, recent developments show a shift from qualifying the boards of appeal as judicial bodies rather than administrative bodies. Their new judicial position has implications for the the functioning of the boards of appeal, as they are likely to operate more like the EU courts rather than the agencies. It is still unclear if and how this new position can be reconciled with the original intended administrative position of the boards of appeal. This shift also address the underlying, and more existential question: why do we have boards of appeal in the first place? This dissertation aims to clarify the nature of the appeal proceedings at the boards of appeal and to explore how the they should be positioned within the European administration. With the use of empirical methods, such as interviews and surveys, the historical, current and intended functioning of the boards of appeal is analysed. This includes looking into procedural and institutional aspects, such as the intensity of review and independence safeguards.


Researchers discuss different applications for neurotech including monitoring criminals, interacting in the metaverse, and enhancing cognitive abilities.
Searches for abortion medications spiked within one how of POLITICO publishing the leak of the SCOTUS ruling, with searches 162% higher during the first 72 hours following the leak. Researchers say there were significantly more searches for abortion medications during the first 72 hours in states that threatened more restrictive reproductive rights.
A new ethical framework proposes researchers should already assume brain organoids already have consciousness, rather than waiting for research to confirm they do.
Study established four general categories of claims made by companies for their consumer-based wearable brain devices. Researchers suggest better ways manufacturers could communicate both the positive and negative outcomes of using their products in a more ethical way.
UCSF researchers report the food and beverage industries push sugary products while obfuscating the significant health issues added sugars can cause. The findings shed light on sugars' link to disease and exposes industrial tactics to downplay the public health risks of diets too high in sugar.
Researchers debate the growing use of tES to enhance creativity, concluding there is a potential value in brain stimulation. However, researchers say, the use of tES raises a number of neuroethical, legal and social issues that must be addressed.


The short messaging service (SMS) is one of the most valuable inventions of the twentieth century, allowing for easier and faster communication than ever before. Despite having a significantly high open rate, SMS is a vastly underutilized marketing medium. With the emergence of instant messaging and social networking platforms, many marketers assume SMS is no longer relevant. However, the truth is that SMS marketing is still one of the most successful digital marketing methods available. Marketers are constantly looking for new methods to boost mobile customer engagement. Several studies show that mobile is a powerful tool for generating sales. ...Read more


Uposatha (Sanskrit, uposadha) is a general term for days of observance in the lunar calendar. All the major Buddhist holidays such as Vesak are uposatha days. This is similar to Hinduism’s Purnima celebrations, which are also keyed to cycles of the moon. The Buddha, in discussion with a laywoman in the Muluposatha Sutta, referred to uposatha (sometimes translated as “sabbath”) as “the cleansing of the defiled mind through the proper technique.” Today, while all Buddhist traditions observe religious holidays, only the Theravada tradition regularly maintains the tradition of uposatha, gathering weekly or bi-weekly.
Uposatha days are ritual cleansing days observed by nuns, monks, and laypeople. Laypeople undertake additional precepts beyond the usual five, specifically celibacy, fasting, avoiding entertainments, and so on. These prohibitions are identical to those undertaken by initiates joining the sangha, except that monastics are not allowed to handle money.
Phases of the moon dictate uposatha. In Southeast Asian Theravada Buddhism, gatherings are held on the full moon, new moon, and quarter moons, while in Sri Lanka, only the full moon and new moon are observed. These days are particularly active at Theravada monasteries, with many lay people visiting, preparing food for nuns and monks in the morning, listening to chanting and sermons, and helping with the maintenance of the monastery grounds. Lay people often dress in white, make offerings, meditate, perform circumambulations, and often spend hours, if not all day, at the monastery.
For Theravada monastics, uposatha is a time of purification. On the new and full moon uposatha days, nuns and monks gather to recite the
Patimokkha (Sanskrit, Pratimoksa), the monastic code of conduct, and confess misdeeds. The Buddha considered this ceremony to be one of the centerpieces of monastic life and one of the practices that defined the sangha. Not attending was excused only in cases of great illness.
While uposatha is commonly observed only in Theravada countries, the practice exists in modified form in some Mahayana traditions. For example, Japan’s
roku sainichi, or six days of fasting (per month), follows the same principles, and laypeople temporarily observe monastic rules. Tricycle is more than a magazine
Gain access to the best in sprititual film, our growing collection of e-books, and monthly talks, plus our 25-year archiveSubscribe now


Digitalisation, EVs, and last-mile logistics represent major challenges and opportunities for local authority parking divisions and private parking operators.
Our new report draws on the experience of local authorities and parking innovators. It shares insight on how to navigate the coming disruption from changes in demographics, behaviour, and sustainability goals, and maximise opportunities from parking space in the post-COVID world.


This educational activity is intended for an international audience of non-US gastroenterologists, dermatologists, and rheumatologists.
The goal of this activity is to increase clinicians' knowledge and competence regarding the management of patients with chronic immune-mediated inflammatory diseases (IMIDs) during the coronavirus disease 2019 (COVID-19) pandemic.
Upon completion of this activity, participants will:
WebMD Global requires each individual who is in a position to control the content of one of its educational activities to disclose any relevant financial relationships occurring within the past 12 months that could create a conflict of interest.
The Faculty of Pharmaceutical Medicine of the Royal Colleges of Physicians of the United Kingdom (FPM) has reviewed and approved the content of this educational activity and allocated it 0.50 continuing professional development credits (CPD).
For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance, contact [email protected]
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This activity is designed to be completed within the time designated on the title page; physicians should claim only those credits that reflect the time actually spent participating in the activity. To successfully earn credit, participants must complete the activity online during the credit eligibility period that is noted on the title page. Follow these steps to claim a credit certificate for completing this activity:
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King, Lauren K; Birmingham, Trevor B; Kean, Crystal O; Jones, Ian C; Bryant, Dianne M; Giffin, J. Robert
The purpose of this study was to evaluate the effects of a 12-wk high-intensity knee extensor and flexor resistance training program on strength, pain, and adherence in patients with advanced knee osteoarthritis and varus malalignment. The results showed significant improvements in knee extensor and flexor strength were observed without increases in pain during or after training.
These findings suggest that patients with advanced knee osteoarthritis and malalignment can experience substantial gains in strength after a high-intensity resistance training program without concomitant increases in pain, adverse events, or compromised adherence.
Medicine & Science in Sports & Exercise, 2008, 40(8), 1376-1384


Date: Tuesday, September 7, 2021 Time: 8.00 - 9.30 AM ET/ 5.30 - 7.00 PM IST
Literacy is crucial for overcoming poverty and contributing to upward social and economic advancement. Yet, despite years of investments, illiteracy continues to be a core impediment to inclusion of individuals on the margins of society, particularly women.
This Digital Empowers virtual session will explore:
The role of literacy as a catalyst for creating transformational social impact and disrupting intergenerational cycles of poverty The impact of illiteracy on businesses and their role in overcoming illiteracy How digital technologies can be leveraged to expand access to literacy and improve learning outcomes The impact of the COVID-19 pandemic on literacy outcomes for youth and adults How national literacy policies and strategies can be improved to provide enhanced support for educators for adult literacy How we can ensure that our youth do not grow up to be unlettered adults?
Please join us for this exciting event by registering on the form.
If you experience any issues with registering for this event, please email
brinda.hardas@tcs.com


Philosophical Explorations12 (1):19 – 40 (2009) AbstractStandard discussions of prudence treat it as requiring time-slice management. That this is the standard view of prudence can be seen by its presence in two seemingly opposed positions on prudence, those of Thomas Nagel and Derek Parfit. I argue that this kind of view fails to properly appreciate the difficulty with being prudent, treating imprudence as a kind of theoretical mistake. I then offer a characterization of prudence as integrity, the holding together of disparate but temporally extended parts of the self in a manner that makes the act of reasoning possible. My notes Similar books and articles
Pagan Virtue and Christian Prudence.Charles Pinches - 1995 -
Journal of Religious Ethics23 (1):93 - 115.
Moral and Political Prudence in Kant.Eric Sean Nelson - 2004 -
International Philosophical Quarterly44 (3):305-319.
Response to “Commentaire Sur le Texte de Sr Prudence Allen Par Jocelyne St-Arnaud”.Prudence Allen - 1987 -
Dialogue26 (2):277.
The Futures of Prudence: Pure Strategy and Aristotelian and Hobbesian Strategists.Nathan D. Grundstein - 1983 - Enterprise Achievement Associates.
Analytics Added to PP
2009-01-28
Downloads
107 (#114,570)
6 months
1 (#417,896)
Historical graph of downloads References found in this work
Self-Constitution: Agency, Identity, and Integrity.Christine M. Korsgaard - 2009 - Oxford University Press.
Reasons and Persons.Joseph Margolis - 1986 -
Philosophy and Phenomenological Research47 (2):311-327.


Overview
Iceland: risk assessment Sovereign
risk
Currency
risk
Banking
sector risk
Political
risk
Economic
structure risk
Country
risk
July 2022 BB BBB BB A B BBB Prianthi Roy (lead analyst); Matthew Oxenford (analyst). Published 01 July 2022, 2100 GMT. The ratings contained in this report and the report itself were produced outside the United Kingdom and therefore are not issued by the EIU credit rating agency, which is registered in accordance with The Credit Rating Agencies (Amendment etc.) (EU Exit) Regulations 2019, SI 2019/266. This report and the ratings, therefore, are not issued pursuant to such Regulations and do not fall within their scope. Nor are this report and these ratings issued pursuant to, or within the scope of, any other regulation including, but not limited to Regulation (EC) No 1060/2009 of September 16th 2009 on credit rating agencies, as amended.
Sovereign risk
The sovereign risk rating remains at BB, supported by firm growth, exports and a falling public debt burden. A still-substantial debt burden, due to ongoing support for the rising cost of living amid the war in Ukraine and the external financing requirement, weigh on the rating, along with Iceland's default in 2011.
Currency risk
The currency risk rating remains unchanged at BBB. A modest rebound in exports and a small current-account surplus in recent months support the rating. As a small, open, largely undiversified economy with a large external-financing requirement, Iceland remains vulnerable to international shocks, notably inflation and asset-price bubbles.
Banking sector risk
The banking sector risk rating remains at BB. Since Iceland's banking crisis, financial supervision has been strengthened and banks remain largely profitable. However, owing to its small size, Iceland's banking sector assets are large as a percentage of GDP, increasing its vulnerability to any potential financial crisis and limiting the potential for further improvement. The score worsens on the back of rising credit growth, falling foreign-exchange reserves and banks' falling net foreign asset position.
Political risk
The rating is unchanged, at A. The coalition that has governed Iceland for the past five years was re-elected in the last election, which has reduced the risk of a snap election. EIU expects it to last a full term to 2025, but Russia's invasion of Ukraine has increased the risk of external conflict and weighs on the rating.
Economic structure risk
Rapid growth in tourism in the years before the pandemic contributed to a reduction in Iceland's reliance on fisheries and finance. However, this has increased the economy's vulnerability, as the tourism sector has only partially recovered from the effects of the pandemic. Iceland's goods exports are similarly undiversified, relying heavily on aluminium smelting and fishing.


Research integration Research
The Centre’s team and affiliates are engaged in the collaborative production, dissemination, and communication of high-quality research.
Topics include, and are not limited to:
Advancing pedagogies that inspire and instill collaborative knowledge and approaches for interprofessional learning - e.g. Teaching for Critical Reflection Understanding the links between IPC, team dynamics, and quality improvement - e.g. Team dynamics within quality improvement teams: a scoping review Innovating collaborative models of care and identifying latent social/collaborative threats - e.g. Getting everyone to the table Designing metrics that drive meaning and collaboration - e.g. Meaningful Impact Building collaborative nudges into technologies for practice, care, and education Engaging in inquiry into high-performing teams to understand the best of collaboration Developing collaborative virtual team-based care Exploring and developing understandings of Student-Led Environments (SLE) and collaborative student leadership models Developing collaborative advocacy and partnered education: www.capelearning.ca Integration
Integrating curricula, knowledge, and practice by connecting people, places, and programs is at the heart of our work and part of our strategic vision’s Aspirations. As knowledge mobilizers and boundary spanners, we infuse varied perspectives and knowledges across all spheres of work within the Centre and focus on integrating the Centre’s work with external communities.
The Centre’s curriculum and professional/faculty development portfolios inform research, scholarship, and evaluation questions while incorporating scientific knowledge and personal/experiential knowledges into curriculum and program development. Valuing patient/client. family/caregivers, learners, and educators as essential partners and meaningful inclusion of their voices in activities from curriculum design to scholarship and evaluation ensures integration of important experiential knowledge in the Centre’s development of collaborative healthcare and education practices.
Our Strategic Advisors connect the Centre to health, education, and policy sectors and ensures a collaborative lens directly informs decision-making for these various community members . The Centre looks to build and strengthen relationships, apply different forms of knowledge, and leverage knowledge and networks to advance collaboration toward the goal of supporting a healthier world. While doing so, we attend to building trust and meaningful partnerships, addressing power relations and its effects on collaborative healthcare and education, and truly valuing and infusing diverse perspectives and knowledges in all our work. Our online supplement on ethical research collaboration may be of interest: www.authorshipethics.com


Each year, the Acumen Fellowship in West Africa selects Fellows from across sectors, countries, and backgrounds who are tackling issues of poverty and injustice, and equips them with the practices and community needed to deepen and sustain their impact.
The Fellowship begins with a year-long fully-funded leadership programme, where Fellows remain in their role while taking part in a series of immersive seminars, workshops, and group practice. This is where practical skills meet moral imagination. The programme is designed to equip Fellows with the tools, mindset, and community to tackle poverty and injustice in their communities
About 2022 Acumen Fellowship Leadership Programme
The Fellowship begins with a year-long leadership programme – where practical skills meet moral imagination. After the first year, Fellows become part of Acumen’s global community of social innovators – committed to lifelong learning, collaboration and accompaniment as they build a world based on dignity.
The Fellowship is a deep commitment and serious investment from Fellows and the Acumen Academy team. Over the course of a year, Fellows will engage in a series of virtual workshops and immersive held across West Africa.
Our curriculum draws on powerful leadership frameworks, tools, and approaches, including Adaptive Leadership, Authentic Voice, Good Society Readings, Immunity to Change, and Polarities Management
Host: Acumen West Africa Fellowship Category: Leadership Training Eligible Country: West Africans Application Closing Date: 12 July 2022 Available Leadership Paths Social Entrepreneur:Founder of a for-profit or non-profit organization that develop market-based solutions to tackle issues of poverty & injustice. Organizational Builder:Supporting the growth of institutions from within (eg. Country Director, CEO, COO) Intrapreneur:Creating solutions from within existing institutions (eg. Team lead, Head of Dept) What you will Learn
Fellows will explore how they can approach personal, organisational and societal challenges differently as they build the tools and mindset to:
Lead diverse stakeholders through recurring and complex challenges Develop stories that speak across lines of difference & move others to action Understand systemic problems and design more effective interventions Navigate uncertainty and embrace the meaningful process of change Cultivate a deeper understanding of yourself and your work Programme Eligibility The Acumen Fellows program in West Africa is for individuals who are leading an initiative in any of these five countries: Ghana, Liberia, Nigeria, Sierra Leone, and The Gambia. English proficiency is a requirement. All seminars and training are conducted in English. We are looking for individuals who currently have a leadership role in an organization or initiative committed to fighting poverty or injustice on a full-time basis. There are no specific academic prerequisites. Programme Benefits Fellows are equipped with the knowledge, support systems and skills to challenge the status quo, work across lines of difference and mobilize their communities. Acumen covers all fellowship-related expenses during the fellowship year. This includes all costs associated with the seminars including lodging, food, transportation, and visas. We do provide need-based scholarships for travel and accommodation for individuals selected to attend for Stage 3 Selection Conference How to Apply for 2022 Acumen Fellowship Leadership Programme
The deadline for the application is 12 July. Upon application submission, our selection team will carefully review submissions and participation at each stage of the process, and select candidates who will advance to the next stage. At each stage of the application process, all candidates will receive communication from our team about the progress of their application. Click the Apply now button below to apply. For more details, visit the official website.


By admin
Global merger and acquisition (M&A) activity fell to its lowest level last year since the financial crisis, but a surge in the final quarter is expected to continue in 2021, according to new data from Willis Towers Watson (WTW).
The research in partnership with the M&A Research Centre at The Business School, formerly Cass, reveals that Covid-19 dragged M&A activity in 2020 to its lowest level for years.
Companies worldwide completed just 674 deals valued at more than $100m. This is significantly less than 774 in the previous year and the lowest annual volume since 332 were record in 2009, according to WTW’s Quarterly Deal Performance Monitor (QDPM).
But the QDPM shows a sharp rise in M&A volume during the final quarter with 246 deals completed worldwide, compared to 210 in Q4 2019. There were 61 large deals valued between $1bn and $10bn, which is the highest ever recorded during a final quarter.
This Q4 resurgence was driven by a strong uptick in North America, which saw a record 136 deals for a final quarter.
WTW said that despite the uncertain economic outlook, conditions are primed for a global “dealmaking surge” in 2021.
Jana Mercereau, head of corporate M&A consulting, Great Britain at WTW, said: “The year 2020 has been unlike anything we’ve ever seen, fuelled by an enduring pandemic, massive economic uncertainty, a highly divisive US presidential election and rising geopolitical tensions. While the world in 2021 remains a volatile place, pent-up demand, ample funding, ultra-low interest rates and confidence returning to boardrooms indicate conditions are ripe for one of the biggest M&A years on record.
“That said, dealmakers should not assume a corner has been turned, with uncertainty set to remain. It will be as critical as ever for acquirers to pick their targets carefully for growth before jumping into a deal, if they are to give themselves the best chance of success. A dedicated focus on HR and people-related risks during due diligence and integration can help achieve this,” she added.
WTW’s monitor also shows that acquirers worldwide have now, on average, failed to add value from transactions for four consecutive years, based on share-price performance. They underperformed the global index by 1.9 percentage points during the past year. But this is an improvement on underperformance of five and three percentage points in 2019 and 2018 respectively.
European buyers, meanwhile, outperformed their regional index by 12.2 percentage points in 2020 and by 5.3 percentage points in Q4.
UK acquirers beat the European Index by 4.1 percentage points for the full year.


Organised by Professor Peter Robinson and Dr Rana el Kaliouby
Charles Darwin highlighted the importance of emotional expression as part of human communication. Advances in computer technology now allow machines to recognise and express emotions, paving the way for improved human-computer and human-human communications.
This meeting will present recent advances in neuroscience, theories of emotion and affect, their embodiment in computational systems, the implications for general communications, and broader applications.
The discussion meeting runs from 9am to 5pm on each day. The registration desk will open at 8.30am on each day.
The meeting programme and book of abstracts is available below. The audio recordings of the meeting are available below.
The proceedings of this meeting are scheduled to be published in a future publication of Philosophical Transactions B.


Data from: Rumbling orchids: how to assess divergent evolution between chloroplast endosymbionts and the nuclear hostOscar Alejandro Pérez-Escobar, Juan Antonio Balbuena & Marc Gottschling
Phylogenetic relationships inferred from multilocus organellar and nuclear DNA data are often difficult to resolve because of evolutionary conflicts among gene trees. However, conflicting or “outlier” associations (i.e., linked pairs of “operational terminal units” in two phylogenies) among these data sets often provide valuable information on evolutionary processes such as chloroplast capture following hybridization, incomplete lineage sorting, and horizontal gene transfer. Statistical tools that to date have been used in cophylogenetic studies only also have...
2 citations reported since publication in 2015.


The digital transformation taking place at the CCA is allowing the institution to rethink its processes. In particular, we question if the role of the institution is still and only “to collect and give access,” or if it can also be “to research and give access”. Find & Tell Elsewhere is a pilot project that is contributing to a potential shift in museum culture and will inform the CCA’s future collaborations. The project is based on the post-custodial model of archival practice and is supported by digital technology, in pursuit of a more collaborative approach to transnational archival work. However, online access does not necessarily mean improved access for everyone, nor should it be mistaken for digital preservation in and of itself. Moreover, there are significant ethical implications must be considered: when we digitize collections, who is doing the labour? Careful engagement with these ethical issues forms a crucial component of the participatory collecting practices that Martien de Vletter, Associate Director, Collection will discuss at The New Institute in the context of digital transformation.
This conference is open to the public (not free).
Het Nieuwe Instituut
Museumpark 25 3015 CB Rotterdam
To register and consult the program, please visit the website of the event.
You can search for everything here—our exhibitions and events, our archives, the library and bookstore, the articles we publish. If you have any questions, please email us at publications@cca.qc.ca.
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Patient Monitoring & Treatment
Dedicated Computing is a strategic supplier for several of the leading healthcare original equipment manufacturers (OEMs). Global OEMs rely on Dedicated Computing to deliver the compute systems needed to power the advanced applications of the patient monitoring and treatment market.
Powering Advanced Applications for the Patient Monitoring and Treatment Market
As the population ages, so does the need for monitoring and treatment of diseases, leading to increased growth in the industry. However, with increased regulation, accountability, and reimbursement issues, we understand the significant challenges our customers face in bringing products to market.
With increased competition, advancements like 3D mapping are also driving changes to the market. Success will be determined by the use of innovative products that improve quality and create efficiencies in the delivery of care.
By partnering with Dedicated Computing, you can stay focused on developing and enhancing your current technology, not on building hardware.
Reduce time to market. Our highly engineered and purpose-built systems are designed to meet the needs of the patient monitoring and treatment industry. Let our engineers focus on optimizing a hardware and software stack that is tailored for your application. Avoid costly validation and verification. We work closely with our customers to reduce the complexity of product lifecycle management – component changes are planned to synchronize with your system updates, not with the IT market. Improve system uptime. Proactive monitoring and management improves reliability and corrects potential failures before they become a reality, avoiding downtime and reducing security threats associated with software stack vulnerabilities.


Tandem Diabetes Care (Nasdaq:TNDM) issued an urgent field safety notice in Europe for its t:slim X2 insulin pump with Basal-IQ technology.
The notice, dated February 2022, alerts users of Tandem’s insulin pump with a software version of 6.3.0.1 that there may be a potential safety risk when using the pump within its normal specifications. Tandem’s t:slim X2 with Control-IQ technology is not affected.
According to the notice, Tandem’s insulin pumps include a “Personal Profile” feature that allows users to personalize the settings that define the delivery of basal and bolus insulin within specific time segments in a 24-hour period. After a user inputs a basal rate into the screen, a “Confirm Settings?” screen is displayed and must be acknowledged, but a user could inadvertently program and confirm a basal rate with an incorrectly placed decimal point.
Inputting incorrect values can lead to under-delivery or over-delivery of insulin, which could result in hyperglycemia or hypoglycemia. Users have been informed by Tandem that they can continue using the pump with extra precautions:
Take extra care when creating or editing your personal profile. Confirm the basal rate change was correctly entered in the “Confirm Settings?” page. Double-check all values entered before advancing past “Confirm Settings?” Regularly check blood sugar to ensure that levels are not unexpectedly high or low.
Tandem will be releasing a t:slim X2 with Basal-IQ technology software update that rectifies the issues noted above, while the company has already implemented an additional feature called “Basal Limit” on the t:slim X2 with Control-IQ technology insulin pumps.


With an estimated 94,324 residents, Suffolk is the ninth-most populous city in Virginia. The city is a great place to live in. Suffolk offers good job opportunities, a moderate cost of living, and fair weather. It is also home to a diverse community of people, a decent nightlife scene, and plenty of outdoor activities.
Notable attractions in Suffolk include the Seaboard Station Railroad Museum, Riddick’s Folly, the Great Dismal Swamp National Wildlife Refuge, the Suffolk Center for Cultural Arts, Suffolk Historic District, Lake Drummond, and St. Luke’s Historic Church & Museum.
In Virginia, there are about 8,725 community associations. These community associations are also found in Suffolk, such as Burbage Grant, Parkside at Bennett’s Creek, and Hillpoint Farms. Virginia’s monthly average HOA dues lie between $200 and $300. However, some associations may charge as much as $1,000 if it is located in an affluent area.
Living in an HOA community offers a lot of advantages. Residents can use the association’s many amenities, which are often exclusive for member use. These amenities can include pools, fitness centers, tennis courts, and even golf courses. Additionally, HOAs can provide services such as garbage removal, landscaping, and common area maintenance.
But, homeowners associations don’t just manage themselves. Board members are tasked with the responsibility of maintaining the entire community. Their duties include preparing the budget, managing the HOA’s finances, collecting dues and assessments, and making sure all common areas are well-maintained.
Because board members are not always well-equipped to handle community management, it is often necessary to hire a professional. This is why HOAs need a Suffolk homeowners association management company.
Association management is often more difficult than it seems. Board members usually have a hard time balancing their duties with other aspects of their personal and professional lives. Many board members also lack the skills needed to keep the community running smoothly.
This is where a Suffolk association management company comes in. With professional assistance, HOA boards can delegate most of their tasks to a trained manager. This will leave them with more time to focus on bigger projects and decisions.
HOA management companies typically provide the following services:
If you need help finding a reliable HOA management company, HOAManagement.com is your best resource. Using our online directory, you can search for HOA management companies, lawyers, and vendors based on your chosen location.


Despite global M&A volume exceeding $3 trillion for the fourth consecutive year, there can be no doubt that uncertainty has affected the transactional market during the past year, and will continue to do so in 2018, but this isn’t to say that all of its effects will be negative.
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Joe manages ITR’s online and print coverage, and the publication’s events worldwide. He covers a range of tax issues affecting multinational corporations, particularly indirect tax matters and case studies.


By Lori Lines
The Power of Words
Think back to a time when someone gave you heartfelt praise, “great job,” “impressive,” or “way to go”! Were you filled with pride, a sense of appreciation, or the satisfaction of accomplishment? Alternatively, can you remember when someone diminished your efforts or harshly criticized you? “I’m disappointed in you?” “Is that the best you could’ve done?” What emotions did that stir within you? How did it make you feel?
Words can hurt, or they can heal. Some wield words as weapons striking out to cause injury. Others carelessly toss words around, unconsciously letting them fall where they may. And there are those sacred moments when we use our words like a soothing balm to comfort the pain of others. Words have power. Yet like a sword, they cut both ways.
“Main Character Energy”
A new term for an old mindset, main character energy, can refer to someone who sees themselves as the main character across circumstances, with others playing supporting roles. This type of worldview is dangerous because things can become deeply personal! A neighbor not saying hello, leads to a whirlwind of theories about how we have offended them. A warm moment between coworkers becomes fodder for a passionate attraction they supposedly feel for us. And an offhanded remark or inconsiderate putdown becomes a profound affront to us, shaking the foundation of our self-esteem.
The reason for someone’s words may be a poor night’s sleep, the fact that you remind them of a selfish ex or demanding parent, or they may not even have intended it the way you perceived it. They may have a blunt way of communicating, or something may have been lost in translation due to text or email. It often has very little to do with us when someone says something offensive… or does it?
Seeing Things as We Are
Anaïs Nin once said, “we don’t see things as they are; we see things as
we are.” And that is why despite the words of others often having very little to do with us, our perception and response ultimately have everything to do with us. Therefore, it is essential to recognize when we feel offended so that we can identify our triggers, mitigate our defensiveness, and use the moment to awaken instead of agonize.
We might feel shameful, sorrowful, or fearful when we are offended. Some people become indignant, full of rage, or vengeful. These are all defense mechanisms the ego-self employs to protect itself from being wounded or triggered. And fundamentally, defense mechanisms are a means of rejecting and denying something that may or may not be true but, nevertheless, disrupts our sense of self and worth. So, be mindful when you feel yourself shutting down or lashing out!
Your Trigger, Your Responsibility
Once we can recognize when we are offended, we soon discover that when someone’s words are offensive, it is often because they poked around an old unhealed wound. It is essential to identify these triggers to strengthen ourselves against future pain and offense and heal past traumas and emotional blockages.
Some questions to ask once you have recognized that you are offended are…
When have I experienced this before?
Who or what do these feelings remind me of?
How did it make me feel then?
How does this trigger me to feel now?
How does this contradict how I perceive myself?
How does this affirm how I perceive myself?
Of course, these questions are just the beginning of learning to acknowledge, find the root of, accept, and heal triggers. Remember, a trigger isn’t a “bad” or shameful thing; it can be a powerful tool for self-exploration and personal growth!
Toxic or Tactful Defensiveness?
Just as triggers aren’t all “bad,” vulnerability isn’t all good. We are often encouraged to be receptive and open-hearted; Genuine has become synonymous with wearing our hearts on our sleeves. However, this, like most extremes, is not healthy. To swing too far on the spectrum, being totally “open” leaves us defenseless against those who would do us harm, destabilize our self-wroth, and compromise our sense of self. Too far in the opposite direction, we would be narrow-minded, emotionally detached, unable, and unwilling to change.
Ultimately, it is the difference between a blockage and a boundary. Boundaries are a matter of self-worth. Blockages stem from self-doubt. Toxic defensiveness is a cage, limiting our growth and keeping away everyone and everything that would challenge our limiting beliefs or lead to change. Tactful defensiveness creates a healthy boundary between you, others, and their opinion. It allows you to define who you are while adapting to who you are becoming.
How to Not Take Things Personally
Taking things personally can significantly impede our self-esteem, ability to communicate with others, and journey to enlightenment. How much more evolved would we all be if we took things a little less personally and chose to be responsive instead of reactive? Learning to do so is a practice; Each day, it is a moment-to-moment choice to move through life consciously, mindful of the grey areas between our perception, reality, and the perception of others. Practicing a
CALM approach to life, you will soon discover the freedom of not taking things personally!
Confidence - Create a self-care routine and spiritual practice that nourishes self-worth and personal conviction. Accountability – Non-judgementally, hold yourself accountable for your perceptions, reactions, growth, and healing. Learn – Take a step back and explore what the “offense” has triggered for you and why. Be willing to learn more about what you need to heal. Move On – Acceptance is a big part of the journey. Even if someone intended to harm you, accept that you cannot control others, only your response; Know when it is time to let go and move on.
In love and truth,
Lori Lines
Author Lori Lines
Disclaimer: Lori is a high-level channel. The information contained on this site is intended for educational purposes only and is not a substitute for advice, diagnosis or treatment by a licensed physician. You should seek prompt medical care for any health issues and consult your doctor before using alternative medicine or making a change to your regimen.
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In this podcast, I have briefly described the concept of meditation and mindfulness meditation. I have also mentioned about just a few benefits that the practice of mindfulness meditation will bring to practitioners.
My intention is to explain this simple yet profound practice that will bring you the gift of self-awareness and self-realization. It helps you to connect to your inner self and become familiar with your thoughts, emotions, and feelings, noticing them as they arise. It empowers you to manage your emotions better.
This practice will clear your mind, and you can live in present moment, more focus, attentive, and in peace!
Namaste,
Gita Nilforoush
Published: June 13, 2016


NCSL Media Alert
March 8, 2021
Washington, D.C.—Immigration-related legislation took a hit in 2020 due to the impact of the pandemic, resulting in 127 state-enacted laws compared with 181 in 2019. Lawmakers also adopted 79 resolutions related to immigration.
A new report, “Immigrant Policy Project: Report on State Immigration Laws, 2020,” by the National Conference of State Legislatures (NCSL), summarizes state laws and resolutions enacted between January and December 2020 and trends in immigration legislation throughout the year.
During this period, states took innovative approaches to sustaining health care and public benefits during the pandemic and addressed barriers to occupational licenses for foreign-trained professionals.
Other key takeaways from the report include:
Twenty-two states enacted 43 laws that appropriated funds. Ten states enacted 14 immigration laws aimed at employment. Nine states enacted 19 immigration laws associated with law enforcement efforts. Four states enacted seven immigration laws connected to education. Sixteen states and the District of Columbia adopted 79 immigration-related resolutions.
The report includes information on the following immigration topics:
Budget. Education. Employment. Health. Human trafficking. ID/driver’s licenses. Law enforcement. Public benefits.
Access “Immigrant Policy Project: Report on State Immigration Laws, 2020.”
NCSL is a bipartisan organization that serves the legislators and staffs of the states, commonwealths and territories. It provides research, technical assistance and opportunities for policymakers to exchange ideas on the most pressing state issues and is an effective and respected advocate for the interests of the states in the American federal system.