Being pregnant and welcoming a new pēpē (baby) into your whānau is exciting and special. But even at the best of times, it can be stressful, emotional and overwhelming. You’re not alone if the COVID-19 situation has you feeling more stressed than normal. Here are tips to help you or a māmā you know get through it.


A wave of academic periodicals devoted to theory started appearing in the 1970s. Criticism wasn't far behind.
Some countries argue that they should keep their ocean territories, even if the land they're based on is submerged.
Emitting just 1 ton of nitrous oxide—a common ingredient in synthetic fertilizer—is roughly equivalent to emitting 300 tons of carbon dioxide.
There's often a disconnect between the ambitions of scientists engaging the public and the potential participants themselves.


Abstract
Various functions for glycosylphosphatidylinositol (GPI) protein anchors have been described in mammalian and protozoan systems. These data suggest that some functions are common to higher and lower eukaryotes, whereas others may represent adaptations that are specifically advantageous to either unicellular or metazoan organisms. In this article, Mike Ferguson discusses the current theories of GPI function that have relevance to protozoan parasites and their mammalian hosts.


Abstract
Bupropion is a widely used antidepressant and smoking cessation aid in addition to being one of two US Food and Drug Administration–recommended probe substrates for evaluation of cytochrome P450 2B6 activity. Racemic bupropion undergoes oxidative and reductive metabolism, producing a complex profile of pharmacologically active metabolites with relatively little known about the mechanisms underlying their elimination. A liquid chromatography-tandem mass spectrometry assay was developed to simultaneously separate and detect glucuronide metabolites of (R,R)- and (S,S)-hydroxybupropion, (R,R)- and (S,S)-hydrobupropion (threo) and (S,R)- and (R,S)-hydrobupropion (erythro), in human urine and liver subcellular fractions to begin exploring mechanisms underlying enantioselective metabolism and elimination of bupropion metabolites. Human liver microsomal data revealed marked glucuronidation stereoselectivity [
Cl int, 11.4 versus 4.3 µl/min per milligram for the formation of (R,R)- and (S,S)-hydroxybupropion glucuronide; and Cl max, 7.7 versus 1.1 µl/min per milligram for the formation of (R,R)- and (S,S)-hydrobupropion glucuronide], in concurrence with observed enantioselective urinary elimination of bupropion glucuronide conjugates. Approximately 10% of the administered bupropion dose was recovered in the urine as metabolites with glucuronide metabolites, accounting for approximately 40%, 15%, and 7% of the total excreted hydroxybupropion, erythro-hydrobupropion, and threo-hydrobupropion, respectively. Elimination pathways were further characterized using an expressed UDP-glucuronosyl transferase (UGT) panel with bupropion enantiomers (both individual and racemic) as substrates. UGT2B7 catalyzed the stereoselective formation of glucuronides of hydroxybupropion, (S,S)-hydrobupropion, (S,R)- and (R,S)-hydrobupropion; UGT1A9 catalyzed the formation of (R,R)-hydrobupropion glucuronide. These data systematically describe the metabolic pathways underlying bupropion metabolite disposition and significantly expand our knowledge of potential contributors to the interindividual and intraindividual variability in therapeutic and toxic effects of bupropion in humans. Footnotes Received December 16, 2015. Accepted January 20, 2016.
This work was supported by the National Institutes of Health (NIH) National Institute of General Medical Sciences [Grant R01 GM078501]. B.T.G. is supported by the NIH General Medical Sciences [Grant T32 GM008425].
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics


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It's one of the justice system's little secrets. Take a selective and sometimes deceptive memory, add flawed police procedures, and witnesses will identify the wrong person — but no one knows how often.
2009 | 3-part Series 1h each | CCIn the aftermath of a crime, especially a violent one, how reliable is human memory? Why can’t police rely on eyewitness accounts to determine exactly what happened? Using hidden cameras, simulated crimes, and ten unsuspecting volunteers, this three-part series reveals the science behind the role of memory in criminal investigation. Interviews with experts in forensic psychology, identification, and the science of human perception help viewers interpret the experiment as it unfolds. Original Open University broadcast title: Eyewitness. 3-part series, 59 minutes each.
This book is designed to provide law enforcement personnel with response guidelines and evidence gathering techniques that may be utilized when responding to an incident involving the use or threatened use of a weapon of mass destruction (WMD).


Diversity of lichens and allied fungi on Norway spruce (Picea abies) in the middle boreal forests of Republic of Karelia (Russia) Abstract
A detailed study of lichen diversity and estimation of epiphytic lichen cover characteristics on spruce as a key ecosystem component was performed in boreal forests of Karelia (NW Russia). The aims of the present paper are: (1) to study lichen diversity on Norway spruce in the middle boreal forests of southern Karelia (NW Russia), and (2) to estimate the main characteristics of epiphytic lichen cover on spruce trunks and branches. In total, 158 species of lichens and allied fungi were found on spruce, including 108 species on trunks, 78 on branches and 55 on snags. Seventeen species are listed in the Red Data Book of Republic of Karelia. Ten species are new for the biogeographical province
Karelia transonegensis and two for the province Karelia onegensis. Twenty-two species are considered old-growth forest indicators. The total epiphytic lichen cover on spruce trees averaged 59% at the trunk base, 12% at a height of 1.3 m above ground level and 61% on branches. Predominantly, only 12 species contributed to the lichen cover of trunk and branches. Despite the predominance of crustose lichens colonising spruce trees, the main epiphytic lichen cover both on trunks and branches was provided largely by foliose species (57% of the total cover). Due to a variety of morphological features, spruce provides diverse microhabitats, which leads to high lichen species richness with different ecological requirements. Spruce trees play a significant role in maintaining the diversity and conservation of rare species. Downloads Folia Cryptogamica Estonica, 55, 133-149. https://doi.org/10.12697/fce.2018.55.14


PSA Conducts PSDP 2018-2023 Update Regional Dissemination Forum for Mindanao Cluster
03 August 2022 – Davao City. The Philippine Statistics Authority (PSA) conducted the Regional Dissemination Forum on the Philippine Statistical Development Program (PSDP) 2018-2023 Update for the Mindanao Cluster on 03 August 2022 at the Grand Regal Hotel, Davao City. The forum was attended by 299 participants (233 online and 66 on-site) representing the member agencies of the Regional Statistics Committees, various regional line agencies, academe, local government units, and the media.
The message of PSA Undersecretary Dennis S. Mapa, National Statistician and Civil Registrar General, underscored the inclusion of statistical development programs (SDPs) to strengthen the local statistical system, and to generate more locally-disaggregated data for more informed decisions in support of countryside development.
Meanwhile, the message from Undersecretary Rosemarie G. Edillon from the National Economic and Development Authority (NEDA) highlighted that statistics should be produced and communicated in such a way that it will be understood by everyone and will stimulate action from policymakers. She also emphasized the need for more disaggregated data and called for stronger collaboration in providing timely, relevant, and reliable statistics.
The highlights of the PSDP 2018-2023 Update which included the formulation process, the accomplishments from 2018 to 2021, and the updated SDPs were presented by Officer-in-Charge (OIC)-Assistant National Statistician Severa B. De Costo in the forum.
Honorable Bai Hundra Cassandra Dominique N. Advincula delivered the keynote message on behalf of Mayor Sebastian Z. Duterte of Davao City. In his message, he emphasized that the PSA plays an important role in providing statistical data and information needed by the government. He mentioned that the cooperation between the PSA and its stakeholders will surely encourage greater collaboration to ensure that the government’s priority projects and programs are aligned with the updated development plan.
PSA-Region IX Regional Director (RD) Mewchun WS. Pamaran presented the highlights of the Regional Statistical Development Program (RSDP) 2018-2023 Update for Regions IX, X, XI, XII, Caraga, and BARMM. This was followed by a panel discussion with RD Phlorita A. Ridao of NEDA-Region IX, RD Mylah Faye Aurora B. Cariño of NEDA-Region X, Mr. Rosendo Aya-ay of NEDA-Region XI, RD Teresita Socorro C. Ramos of NEDA-Region XII, RD Priscilla R. Sonido of NEDA-Caraga, and Director General Mohajirin T. Ali of Bangsamoro Planning and Development Authority-BARMM, as panelists, while Mr. John Frederick P. De Guia served as the moderator. The panelists recommended more data innovations, investments in technology, and that the statistics produced should be timely and relevant, among others. It was also suggested that the successor RSDP be reflective of the statistical needs of the regions, such as the need to adopt various statistical frameworks and indicators like the Tourism Satellite Accounts and Climate Change Indicators.
PSA OIC-Deputy National Statistician Minerva Eloisa P. Esquivias concluded the event with a call on everyone to continually exert efforts for the successful implementation of the PSDP and RSDP 2018-2023 Update.
- Censuses and Technical Coordination Office


Our practical understanding of the challenges businesses face in the context of decarbonization, helps us make sense of the complex decisions and considerations faced. By working closely with our clients to understand the individual needs of their business, we accompany them on the journey and are driven by their successes.
Both for a corporates’ own operations or with a supply chain focus, the roadmap creates a foundation to align market insights with an understanding of what the renewable energy transition can deliver. We strive to enable our clients to make strategic, informed decisions that result in the best-suited solutions for their business goals.


Article
The Protecting Access to Medicare Act
A comprehensive AUC consultation requirement
The Protecting Access to Medicare Act (PAMA) requires that physicians ordering advanced imaging exams consult Appropriate Use Criteria (AUC) through a qualified Clinical Decision Support Mechanism (qCDSM).
Ordering providers
1 are required to consult AUC for all Medicare Part B advanced diagnostic imaging services (CT, MR, NM, PET).
Consultation is required in all applicable settings as outlined by the Centers for Medicare & Medicaid Services. These include physician offices, hospital outpatient departments (including emergency departments), ambulatory surgical centers, and independent diagnostic testing facilities.
Program Timeline Priority clinical areas and physician measurement
CMS has outlined eight priority clinical areas (PCAs) as a baseline of clinical coverage to measure outlier physicians:
Coronary artery disease (suspected or diagnosed) Suspected pulmonary embolism Headache (traumatic and nontraumatic) Hip pain Low back pain Shoulder pain (to include suspected rotator cuff injury) Cancer of the lung (primary or metastatic, suspected or diagnosed) Cervical or neck pain
Outlier calculation will be based on both AUC adherence within the PCAs and applicability of the AUC to the service. In addition to outlier calculation, the PCAs can serve as a guide to begin your CareSelect
® Imaging implementation. With a focus on quality improvement opportunities, the PCAs offer a springboard to create immediate impact to address imaging overutilization. What information is required on the claim?
CMS will accept all consultation data, as defined by the regulation, in the form of G-codes with Healthcare Common Procedure Coding System (HCPCS) modifiers. The G-code will be used to define the qCDSM ID, and CPT will be amended with HCPCS modifiers to indicate pertinent AUC consultation data.
The defined information is as follows:
Information about which qCDSM was consulted by the ordering professional for the service. Information regarding: Whether the service ordered adheres to the applicable AUC. Whether the service ordered does not adhere to such criteria. Whether such criteria are not applicable to the service ordered. The NPI of the ordering professional. All claims will require CPT codes appended with the appropriate HCPCS modifier and G-codes that indicate which CDSM was consulted to qualify for payment.
Qualified CDSMs have been assigned a G-code that is specific to each mechanism.
In addition to the G-code/HCPCS modifier structure, CareSelect Imaging produces a unique consultation identifier (UCI) or decision support number (DSN). While the DSN is not required for claims purposes, it provides a valuable link between consultation and claims data. This is particularly important when the ordering and furnishing facilities are disparate domains. CareSelect retains this information for six years.
Exemptions
CMS has finalized three circumstances where ordering providers are not required to consult AUC.
These have been defined as:
Emergency services 2 If the service is furnished under Medicare Part A Hardship
The 2019 final rule clarifies the proposed hardship exclusion and makes the ordering provider “self-report” their exclusion from criteria; 2019 rule-making finalized a definition for “hardship” as:
Insufficient Internet access EHR or CDSM vendor issues Extreme and uncontrollable circumstances
These criteria add to the existing emergency services exclusion, where consultation is not required if it will cause undue harm to the patient.
The 2019 rule finalizes the proposal for ordering professionals experiencing a significant hardship to self-attest and include that information on the order. The furnishing professional or facility would communicate on the Medicare claim for the service by appending an HCPCS modifier identifying the ordering professional’s self-attested significant hardship category.
1 The following roles are defined as “ordering professionals” by the statute: a) A physician assistant, nurse practitioner, or clinical nurse specialist b) A certified registered nurse anesthetist c) A certified nurse-midwife d) A clinical social worker e) A clinical psychologist f) A registered dietitian or nutrition professional 2 Emergency Services have been defined in Section 1867 of the Social Security Act. The term “emergency medical condition” means: a) A medical condition manifesting itself by acute symptoms of sufficient severity (including severe pain) such that the absence of immediate medical attention could reasonably be expected to result in: i. Placing the health of the individual (or, with respect to a pregnant woman, the health of the woman or her unborn child) in serious jeopardy. ii. Serious impairment to bodily functions. iii. Serious dysfunction of any bodily organ or part. b) With respect to a pregnant woman who is having contractions: i. That there is inadequate time to affect a safe transfer to another hospital before delivery. ii. That transfer may pose a threat to the health or safety of the woman or the unborn child..


Lag control v4
Data throughput of database applications on a BDR origin node can exceed the rate at which committed data can be safely replicated to downstream peer nodes. If this disparity persists beyond a period of time or chronically in high availability applications, then organizational objectives related to disaster recovery or business continuity plans might not be satisfied.
The replication lag control (RLC) feature is designed to regulate this imbalance using a dynamic rate-limiting device so that data flow between BDR group nodes complies with these organizational objectives. It does so by controlling the extent of replication lag between BDR nodes.
Some of these objectives include the following:
Recovery point objective (RPO) specifies the maximum tolerated amount of data that can be lost due to unplanned events, usually expressed as an amount of time. In nonreplicated systems, RPO is used to set backup intervals to limit the risk of lost committed data due to failure. For replicated systems, RPO determines the acceptable amount of committed data that hasn't been safely applied to one or more peer nodes.
Resource constraint objective (RCO) acknowledges that there are finite storage constraints. This storage includes database files, WAL, and temporary or intermediate files needed for continued operation. For replicated systems, as lag increases the demands on these storage resources also increase.
Group elasticity objective (GEO) ensures that any node isn't originating new data at a clip that can't be acceptably saved to its peer nodes. When that is the case then the detection of that condition can be used as one metric in the decision to expand the number of database nodes. Similarly, when that condition abates then it might influence the decision to contract the number of database nodes.
Lag control manages replication lag by controlling the rate at which client connections can commit READ WRITE transactions. Replication lag is measured either as lag time or lag size, depending on the objectives to meet. Transaction commit rate is regulated using a configured BDR commit-delay time.
To get started using lag control:
Determine the maximum acceptable commit delay time
bdr.lag_control_max_commit_delaythat can be tolerated for all database applications.
Decide on the lag measure to use. Choose either lag size
bdr.lag_control_max_lag_sizeor lag time
bdr.lag_control_max_lag_time.
Decide on the number of BDR nodes in the group
bdr.lag_control_min_conforming_nodesthat must satisfy the lag measure chosen in step 2 as the minimal acceptable number of nodes.
Lag control is configured on each BDR node in the group using
postgresql.confconfiguration parameters. To enable lag control, set
bdr.lag_control_max_commit_delay and either
bdr.lag_control_max_lag_size or
bdr.lag_control_max_lag_time to positive non-zero values.
bdr.lag_control_max_commit_delay allows and encourages a specificationof milliseconds with a fractional part, including a sub-millisecondsetting if appropriate.
By default,
bdr.lag_control_min_conforming_nodes is set to 1.For a complete list, see Lag control
Lag control is a dynamic TPS rate-limiting mechanism that operates at the client connection level. It's designed to be as unobtrusive as possible while satisfying configured lag-control constraints. This means that if enough BDR nodes can replicate changes fast enough to remain below configured lag measure thresholds, then the BDR runtime commit delay stays fixed at 0 milliseconds.
If this isn't the case, minimally adjust the BDR runtime commit delay as high as needed, but no higher, until the number of conforming nodes returns to the minimum threshold.
Even after the minimum node threshold is reached, lag control continues to attempt to drive the BDR runtime commit delay back to zero. The BDR commit delay might rise and fall around an equilibrium level most of the time, but if data throughput or lag-apply rates improve then the commit delay decreases over time.
The BDR commit delay is a post-commit delay. It occurs after the transactionhas committed and after all Postgres resources locked or acquired by thetransaction are released. Therefore, the delay doesn't preventconcurrent active transactions from observing or modifying its values oracquiring its resources. The same guarantee can't be made for externalresources managed by Postgres extensions. Regardless of extensiondependencies, the same guarantee can be made if the BDR extension is listedbefore extension-based resource managers in
postgresql.conf.
Strictly speaking, the BDR commit delay is not a per-transaction delay. It is the mean value of commit delays over a stream of transactions for a particular client connection. This technique allows the commit delay and fine-grained adjustments of the value to escape the coarse granularity of OS schedulers, clock interrupts, and variation due to system load. It also allows the BDR runtime commit delay to settle within microseconds of the lowest duration possible to maintain a lag measure threshold.
Note
Don't conflate the BDR commit delay with the Postgres commit delay. They are unrelated and perform different functions. Don't substitute one for the other.
The BDR commit delay is applied to all READ WRITE transactions that modify data for user applications. This implies that any transaction that doesn't modify data, including declared READ WRITE transactions, is exempt from the commit delay.
Asynchronous transaction commit also executes a BDR commit delay. This might appear counterintuitive, but asynchronous commit, by virtue of its performance, can be one of the greatest sources of replication lag.
Postgres and BDR auxillary processes don't delay at transaction commit. Most notably, BDR writers don't execute a commit delay when applying remote transactions on the local node. This is by design as BDR writers contribute nothing to outgoing replication lag and can reduce incoming replication lag the most by not having their transaction commits throttled by a delay.
The maximum commit delay
bdr.lag_control_max_commit_delay is a ceilingvalue representing a hard limit. This means thata commit delay never exceeds the configured value. Conversely, themaximum lag measures
bdr.lag_control_max_lag_size and
bdr.lag_control_max_lag_time are soft limits that can be exceeded.When the maximum commit delay is reached, there's no additionalback pressure on the lag measures to prevent their continued increase.
There's no way to exempt origin transactions that don't modify BDR replication sets from the commit delay. For these transactions, it can be useful to SET LOCAL the maximum transaction delay to 0.
Application TPS is one of many factors that can affect replication lag. Other factors include the average size of transactions for which BDR commit delay can be less effective. In particular, bulk load operations can cause replication lag to rise, which can trigger a concomitant rise in the BDR runtime commit delay beyond the level reasonably expected by normal applications, although still under the maximum allowed delay.
Similarly, an application with a very high OLTP requirement and modest data changes can be unduly restrained by the acceptable BDR commit delay setting.
In these cases, it can be useful to use the
SET [SESSION|LOCAL] command tocustom configure lag control settings for those applications or modifythose applications. For example, bulk load operations are sometimes splitinto multiple, smaller transactions to limit transaction snapshot durationand WAL retention size or establish a restart point if the bulk load fails.In deference to lag control, those transaction commits can also schedule verylong BDR commit delays to allow digestion of the lag contributed by theprior partial bulk load.
In the example objectives list earlier:
RPO can be met by setting an appropriate maximum lag time. RCO can be met by setting an appropriate maximum lag size. GEO can be met by monitoring the BDR runtime commit delay and the BDR runtime lag measures,
As mentioned, when the maximum BDR runtime commit delay is pegged at the BDR configured commit-delay limit and the lag measures consistently exceed their BDR-configured maximum levels, this scenario can be a marker for BDR group expansion.
export const _frontmatter = {"title":"Lag control"}


CODE OF CONDUCT
Only licensed or registered persons may engage in regulated activities in Hong Kong, which include sponsoring IPOs and bookbuilding/placing in a share or debt offering. In conducting such activities, they must comply with the revised Code of Conduct for Persons Licensed by or Registered with the Securities and Futures Commission.
CAUSE FOR CONCERN
While syndicate members in Hong Kong IPOs are given more leadership titles, responsibilities over key activities become less defined among the many leaders.
Also, the SFC notes increasing concern over the behaviour of intermediaries engaged in IPOs not in line with maintaining a healthy capital market, or possible conflicts of interest. For example, firms marketing the offering to investors without a mandate from the issuer, and subsequently convincing the issuer to accept them as syndicate members.
In this case, the issuer provides fee incentives at a late stage, further bringing about last-minute scrambles for orders and fees. Syndicate leaders thus have much less control over the whole bookbuilding and share allocation exercise at the last critical phase of the IPO.
For IPO sponsorship, the SFC also notices that fees are currently not aligned with sponsors’ costs and responsibilities. Based on its analysis of 99 IPOs listed from January to September 2020, the average sponsor fee was HKD6.3 million (USD804,000) and the average underwriting fixed fee was HKD43.9 million. This causes concerns over sufficient effort by sponsors in conducting due diligence on the issuers.


What Is Bank Discount Basis?
Bank discount basis, also known as discount yield, is a convention used by financial institutions when quoting prices for fixed-income securities sold at a discount, such as municipal and U.S. Treasury bills. The quote is presented as a percentage of face value and is determined by discounting the bond by using a 360-day-count convention, which assumes there are twelve 30-day months in a year.
Key Takeaways The bank discount bias, or discount yield, calculates the expected return of a bond sold at a discount to its par value, or face value. It is most often used to determine the yield on treasury bills, commercial paper, and municipal notes. These bonds are purchased at a discount, held to maturity, and then sold at face value, netting the holders a profit. The bank discount bias, an annualized yield expressed as a percentage, is determined by using a 30-day month and a 360-day year. Understanding Bank Discount Basis
The bank discount basis is an annualized yield stated as a percentage. It is the return on investment generated by purchasing the instrument at a discount and then selling it par when the bond matures. Treasury bills, along with many forms of corporate commercial paper and municipal notes, are issued at a discount from par value (the face value). U.S. Treasury bills have a maximum maturity of 52 weeks, while Treasury notes and bonds have longer maturity dates.
While the 30/360 day-count convention is the standard banks use when quoting treasury bonds, the bank discount rate will be lower than the actual yield on your short-term money market investment, because there are 365 days in a year. Therefore, the rate should not be used as an exact measurement of the yield to be received. Over longer maturities, the day count convention will have a greater impact on the current "price" of a bond than if the time to maturity is much shorter.
To convert a 360-day yield to a 365-day yield, simply "gross-up" the 360-day yield by the factor 365/360. A 360-day yield of 8% would equate to an 8.11% yield based on a 365-day year.
8%×360365=8.11%
If an investor sells a security before the maturity date, the rate of return earned will be based on the sale price of the security at the time. It might be higher or lower than the price the investor would have seen had the bond been held to maturity.
How To Calculate the Bank Discount Rate
The bank discount basis, or bank discount rate, is calculated using the following formula:
Bank Discount Rate=PVDPV×Days to Maturity360BankDiscountRate=PVPV−PP×Days to Maturity360where:DPV=Discount from par valuePV=Par valuePP=Purchase price
Assume an investor purchases a $10,000 Treasury bill at a $300 discount from par value (a price of $9,700), and that the security matures in 120 days. In this case, the discount yield is:
$10,000 par value$300 discount×120 days to maturity360
or a 9% yield.
Discount Yield vs. Bond Accretion
Securities sold at a discount use the discount yield to calculate the investor's rate of return, and this method is different than bond accretion. Bonds that use bond accretion can be issued a par value, at a discount or at a premium, and accretion is used to move the discount amount into bond income over the remaining life of the bond.
Assume an investor purchases a $1,000 corporate bond for $920, and the bond matures in 10 years. Since the investor receives $1,000 at maturity, the $80 discount is bond income to the owner, along with the interest earned on the bond.
Bond accretion, however, means the $80 discount is posted to bond income over the 10-year life, and an investor can use a straight-line method or the effective interest rate method. Straight-line posts the same dollar amount into bond income each year, and the effective interest rate method uses a more complex formula to calculate the bond income amount. Bonds with a coupon can also be quoted at on a yield basis.


OUR CHALLENGE: First-time collaborator – Finding a research partner
Archway is an SME that designs and manufactures road repair equipment in Co. Leitrim. We’ve developed specialised equipment with several patented features for spray injection patching. This process involves a precisely controlled mixture of aggregate and bitumen emulsion that’s simultaneously pre-mixed and sprayed into road potholes. It’s more efficient and sustainable than traditional forms of patching.
Spray injection patching is a relatively new area, however understanding the chemistry is challenging. We needed to evaluate the properties of the materials to identify the optimum and edge conditions, so we had the right mix at the right time. A literature search yielded nothing so we knew we needed to find an academic partner and conduct our own research.
As we had no knowledge of relevant researchers in Ireland, we turned to IRDG who circulated our challenge to the academic institutions. We were delighted with the response which identified several key researchers with the expertise we were looking for.
Brexit is demanding our attention presently, but we will soon begin the process of choosing our partner. This will be a new experience for Archway and we look forward to collaborating to deliver the outcome of a gold-standard operating procedure for the spray injection patching process. This will keep us at the forefront of the market, and meeting the needs of key customers such as the Department of Transport UK.


Water theft is a growing concern in California, with illegal cannabis cultivators one of the main contributors to water scarcity. In the midst of a severe drought, illegal growers have been siphoning water from fire hydrants, drilling unauthorized water wells, breaking into secure water stations and drilling into water lines. The diversion of water can threaten supply to hundreds of local residents’ homes, particularly when water valves are improperly shut off, and can cause tens of thousands of dollars of damage.
A recent sting in Antelope Valley, Los Angeles, saw the seizure of two water trucks and 19 individuals charged with water theft. According to Curt Fallin, a Drug Enforcement Administration special agent, the water used by illegal cannabis grow operations in Los Angeles, Riverside, and San Bernardino has been estimated at approximately 5.4 million gallons of water per day. Water theft by illegal growers, however, is not a new phenomenon. As the number of illegal growers explodes, so too does illicit water use.
In 2020, the Narcotics Bureau identified 150 illegal outdoor operations in the Antelope Valley. In 2021, more than 500 illegal grow sites were found during reconnaissance flights. Scientists have also found that the state’s main watersheds are losing water rapidly due to unlawful cannabis cultivation. The plundering of water from watersheds additionally represents a source of potential damage and strain to fragile ecosystems already pressured by unprecedented droughts. Many protected species, such as Chinook salmon and steelhead trout, inhabit the watersheds. In one recent raid of illegal grow sites, the Humboldt County Sheriff’s Office Marijuana Enforcement Team found about 100 environmental violations and juvenile fish in dammed pools in the watersheds where water was being illegally pumped.


Wheat, maize, peas, mustard are the major Rabi crops have reported major losses.Accurate figures are yet to be ascertained. Rains had started during the early morning hours and continued throughout the day.
According to Skymet Weather, an active Western Disturbance over Jammu and Kashmir had induced a cyclonic circulation over Northwest Rajasthan. Both the systems were strong in nature and thus, resulted in widespread rain and thundershowers. However,
it was intense hailstorm that has caused the major damage to the standing crop.
At present, the crop was in standing stage and such intense weather activity can either destroy the crop completely or damage the quality. We are afraid that one of both might be the case this time.
Both the prevailing weather systems have now moved away, and rains have also departed. However, this is not all, as
weathermen are predicting another spell of rain and thundershowers next week.Although intensity of weather activities would not as intense as this week, but threat of crop damage still looms large.


- See: aminoglycosides and addition of aminoglyocides to cement
- Discussion: - adult dose w/ normal renal F(x) & serious infection: 1mg/kg q8hr; - peds: 7.5 mb/kg/day q8hr (Levels: trough <2; peak: 4-8 hr) - for life threatening infection may use 1.66mg/kg q8hr (reduce dose as soon as possible); - commonly added to cement for treatment of infections; (see: addition of tobra to cement / addition of antibiotics to cement) - gent and tobra may have similar antibacterial spectra; however, in vitro a given concetration of tobra is may be twice as effective as gent against pseudomonas - tobra is more active than gent against pseudomonas, including gent-resistant strains, and is usually indicated over gent for pseudomonas infections, in combination with an antipseudomonal penicillin (AMA, 1983). - diffusion from blood into CSF minimal even w/Inflammation; - Cautions: - in patients with impaired renal f(x); - give initial loading dose of 1mg/kg; - additional doses should be adjusted based on the creatinine clearance; - must measure serum levels; use with caution in patients w/ renal failure; - avoid other nephrotoxic, ototoxic drugs; Monitor CN VIII F(x); - note that advanced age and dehydration increase the risk of toxicity; - dosing regimens for patients with renal insufficiency: dose for 70kg adult: gm / dosing interval (hr): - >80: 0.10-.14/8; CrCl:50-79:.10-.14/8-12hr; - CrCl:30-49:0.10-0.14/12-18hr; CrCl:10-29:: 0.10-0.14/24-36hr; - 84-93% of drug will be excreted in to urine (w/ nl RF(x)); - supplement dose after dialysis: - hemo: 1-2 mg/kg - CAPD: 3-4 mg/Lit of dialysis - neuromuscular blockade; hallucinations; - interactions: - will interact with cephalothin (nephrotoxicity), Cis platin (nephrotoxicity, ototoxicity) - neuromuscular blocking agents (apnea or respiratory paralysis), loop diuretics (ototoxicity), penicilln in RF (decrease aminoglycocans effectiveness) vancomycin (nephrotoxicity), oral anticoagulants (increase PT) - References for Tobramycin:
- References for use with Calcium Sulfate Beads:
- Local and Systemic Levels of Tobramycin Delivered from Calcium Sulfate Bone Graft Substitute Pellets - Systemic exposure to tobramycin after local antibiotic treatment with calcium sulphate as carrier material - Effectiveness of commercially-available antibiotic-impregnated implants - Antibiotic Beads and Osteomyelitis: Here Today, What's Coming Tomorrow? - Antibiotic-impregnated Calcium Sulfate Use in Combat-related Open Fractures - In vitro gentamicin release from calcium phosphate bone substitutes influence of carrier type on duration of the release profile - Tobramycin-impregnated Calcium Sulfate Prevents Infection in Contaminated Wounds - The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant - USE OF BIODEGRADABLE ANTIBIOTIC BEADS IN ORTHOPAEDIC INFECTIONS - Treatment of Infected Hip Arthroplasty with Antibiotic-Impregnated Calcium Hydroxyapatite. - Antimicrobial Bone Graft Substitutes - The in vitro elution characteristics of vancomycin from calcium phosphate-calcium sulfate beads. - Locally-administered antibiotics in wounds in a limb - Clinical Application of Tobramycin-Impregnated Calcium Sulfate Beads in Six Dogs (2002-2004) - In vitro comparison of elution characteristics of vancomycin from calcium phosphate cement and polymethylmethacrylate - Effectiveness of Local Antibiotic Delivery with an Osteoinductive and Osteoconductive Bone-Graft Substitute
The absence of nephrotoxicity and differential nephrotoxicity between tobramycin and gentamicin.
Wound and serum levels of tobramycin with the prophylactic use of tobramycin-impregnated polymethylmethacrylate beads in compound fractures. Aminoglycoside pharmacokinetics: dosage requirements and nephrotoxicity in trauma patients. Comparative cost effectiveness of gentamicin and tobramycin. Systematically individualizing tobramycin dosage regimens.
What Is the Role of Antibiotic-Containing Cement in Total Knee Arthroplasty?: Commentary on articles by Robert S. Namba, MD, et al.: “Risk Factors Associated with Deep Surgical Site Infections After Primary Total Knee Arthroplasty. An Analysis of 56,216 Knees,” and Pedro Hinarejos, MD, PhD, et al.: “The Use of Erythromycin and Colistin-Loaded Cement in Total Knee Arthroplasty Does Not Reduce the Incidence of Infection. A Prospective Randomized Study in 3000 Knees”


Marketers are facing performance issues and their leaders are facing the heat. Average CMO tenure in 2021 was 40 months, the lowest in more than a decade, according to Spencer Stuart, an executive search firm. A 2020 study by Korn Ferry, another executive search firm, found average CMO tenure was 3.5 years, the lowest of all C-suite titles.
We live in a world of intense competition to win new business and retain customers. Customers are facing product parity – most products are as good as everything else on offer. Marketers can no longer acquire customers by building awareness about features and benefits of their products.
Marketers must start positive conversations with and about their brands to get leads, increase sales and create raving fans. To make this happen, they must inspire their customers with three Cs – Content, Capability and Campaign. Content marketers must create, new capabilities they must develop, and how they should execute campaigns to engage with their audiences effectively. Here's also a look at how top brands are using this "3C" model to trigger change in attitudes and buying behaviours in their favour.
Content
Brand recognition is no longer enough. Customers expect brands to differentiate themselves through meaningful content. What type of content must you create? Don’t overwhelm your audience with the features and benefits of your solution.
Your content must inspire, entertain or educate your audience. “Authentic content” and “Relatable content” are among the most effective content types, according to 2022 State of Inbound esb电竞数据投注电脑版 Trends report published by HubSpot,
Authentic and relatable content has helped Red Bull to generate about US$6.9billion in revenues in 2021. It also features in Forbes’ 2021 list of most valuable brands. Red Bull produces videos and even magazines. The content appeals to its target audience: physically actively people with a high-energy lifestyle. It showcases extreme sports and aims to inspire its customers to challenge the limits they may have set for themselves. Red Bull never talks about its energy drink.
According to the book,
The Challenger Sale , successful B2B companies challenge their clients with commercial insights. A commercial insight is a compelling perspective from a supplier that directly addresses a client’s business drivers and leads back to the supplier’s unique capabilities. A company will have one or more of these seven business drivers: increase revenue, decrease costs, utilise assets, mitigate risks, improve efficiencies, build employer brand, drive innovation. An insight that focuses on these business drivers becomes a compelling commercial insight.
Marketers must investigate their clients’ business drivers by collaborating with subject matter experts. They must create commercial insights addressing these drivers. McKinsey Quarterly, a newsletter, is a dependable resource for global executives to help them address their most critical business drivers.
esb电竞数据投注电脑版 teams must act like media organisations. TED Talk videos have transformed how people educate themselves. You must create more informational videos. Clients love to learn from their peers. You must recruit existing clients to share how they overcome their challenges.
Capability
Customers self-educate on a purchase using digital channels, before engaging with a supplier. According to marketing consultancy Sirius Decisions, 70% of the buyer’s journey is complete before a buyer even reaches out to a sales team.
Therefore, the best driver for increasing sales is to teach the customer something new. This requires a new set of marketing skills. Skills related to writing content for flyers, creating brochures and executing roadshows are important skills, but they are no longer enough. Successful marketers adopt a newspaper's mindset for their brand. They think like a publisher and act like a journalist. They figure out what would make news, and what type of content is likely to get their audience inspired. They tell stories that appeal to both needs and aspirations.
Marketers must be change agents. The secret of change is to focus all of your energy not on fighting the old, but on building the new. Marketers must create a “hot cause” that arouses emotion and forges a collective identity. They must also introduce “cool mobilisation” techniques that inspire action and sustain commitment.
The hot cause for marketers now is to turbocharge sales. For this to happen, you must transform the way your organisation shares content with the outside world. The cool sources of mobilisation are content advocacy tools such as GaggleAMP and Dynamic Signal. These tools make it very easy for every employee to amplify their organisation’s insights via their personal social media feeds. Other cool tools are cloud-based video creation applications such as Wochit. They make it fun to produce high-quality videos quickly.
Campaign
A campaign is a series of marketing activities designed around content assets and tools. It focuses on building loyalty or acquiring new customers. To execute a campaign, you must think about the questions you will ask and the insights you will share. Content assets used in a campaign include: research reports, opinion pieces, slide decks, blog posts, infographs, video clips, whitepapers, social media posts and client stories. Campaign tools help to amplify these content assets to engage with audiences. These include landing pages, webinars, events, email, direct mail, LinkedIn, Twitter, blogs, newsletters, speaking slots and sponsorships.
You must also execute a pull-based strategy using web content. This must include keywords used by your prospective clients to research solutions, so that they are drawn to your message. Use SEM to make sure your content gets found online.
Don’t underestimate PR. Help journalists write stories by providing them insights and data related to your industry. Use these stories to add a solid layer of credibility to your brand. A campaign turns your business into a series of critical moments. It is enabled by content writers, PR experts, designers, SEO experts, and CRM tools such as Eloqua and Salesforce. And it is supported by timely tracking and follow-up of leads.
The digital HR campaign of professional services firm Aon is an example of a successful campaign. The aim of the firm was to raise awareness about creating a consumer-grade experience for employees, and to acquire new clients for its transformation services.
Aon’s marketing team interviewed its subject matter experts, extracted commercial insights, wrote an opinion piece and pitched it to the trade-journals. This resulted in many published pieces. Those insights were shared during events. The team then extracted sound bites from there and converted them into blogs, video clips, infographs and a whitepaper. These were hosted on Aon.com and promoted via LinkedIn.
By repurposing insights into multiple content assets, this campaign helped Aon to engage with their clients in different ways and multiple times. This created highly qualified leads and new sales for Aon’s services. You will build a thriving marketing career if you focus on starting new conversations that grow revenue. The world is your oyster when you create new customers and raving fans with content, capability and campaigns.
The writer is marketing veteran and former Aon head of marketing and communications Maneesh Sah.


I started content writing without a laptop. Yes, you can read that again! Well, It's not because I didn't like one, but because I couldn't afford it.
I wrote every day on my android phone, sometimes trying to complete 10,800 words (set articles from a client) in a day and working 8am to 12am Monday to Sunday, without holidays to make enough for sustainability. The pay was meagre, though, but I was passion-driven.
When I got paid for writing or editing, no matter how little, I felt fulfilled because this was something I could do for free.
Then, I registered on Upwork. Being a highly competitive platform, I struggled to land my first gig. I tried different things, from rewriting my bio and title to adjusting my hourly rates and changing my profile picture. I checked online to read more about getting jobs on Upwork and kept checking every thirty minutes to see if there were new job uploads I could bid for.
During this period, I kept working on myself. I read more books, especially inspirational books, to keep me going. I also understood that to be a good writer; one must be a good reader. Thus, I invested significantly in reading and personal development.
I read about many great people who started from nothing and built the kind of life they wanted. One of these people stands out — Abraham Lincoln, the 16th president of the United States. I read about how he lost his mother at a young age and could only afford about twelve months of formal education. However, his poor background didn’t stop him from becoming a self-trained lawyer and, consequently, a representative in the Illinois house of representatives. Lincoln defied all odds and became the president of one of the most powerful nations on earth.
After reading about this icon, I was more motivated to succeed than ever, and I took him as a role model. I remember looking at myself in the mirror and saying, “Abraham Lincoln got it worse than me at the beginning, but he eventually succeeded. If he can do it, so can I.”
Although, at a point, I wanted to quit, thinking this was not for me. However, I had no better alternative to reach the kind of clients I desired than Upwork quickly. Thus, I kept trying. I’d set my alarm in batches so that I wake every two hours at night to see if clients have responded and check if there are new content writing, editing, or video transcription jobs to bid on — I didn’t want to miss a single opportunity.
Eventually, I landed my first job on Upwork, but the big break happened when I got a video transcription gig a few weeks after my first gig. There were over 50 proposals submitted, but I think mine stood out because I had the perfect sample for the job. Unfortunately, the task can't be completed on an android phone except with a laptop. I checked my account balance, perhaps to get a laptop, but it frowned at me.
What should I do? Should I borrow a laptop for this long-term project? Should I reject the offer because I don't have the facility? None seems like a smart move. So, I reached out to a friend to borrow $400 to purchase a new laptop. He did, and guess what, I went on to earn almost $5000 from the job. Six months later, I made over $20k on Upwork with a top-rated plus badge by delivering top-notch content for individuals and companies across the world.
If you do the math, you'd realize that not only can I purchase any laptop of my choice today, I can, in fact, buy as many laptops as I want, perhaps to start a laptop retailing business. Lol. A few days ago, I purchased my first house in Lagos, Nigeria.
Reminiscing about my content writing journey, I realized I wouldn't have come this far if I had waited to have all I needed before starting my freelance career as a content writer and editor. If I chose to wait until I could afford a laptop, I'd still be where I used to be. But I dared to try; I started with what I had.
So, I ask you, my friend, what is holding you back from pursuing your dream?
This article was submitted by and expresses the views and opinions of the individual listed as the author. They do not necessarily represent the views or opinions of Upwork, and Upwork does not explicitly sponsor or endorse any of the views, opinions, tools or services mentioned in this article, all of which are provided as potential options according to the view of the author. Each reader and company should take the time needed to adequately analyze and determine the tools, practices, and services that would best fit their specific needs and situations.


One of the most critical factors in a successful options trading strategy is having clear and well-defined objectives. Whether you are looking to find short-term opportunities, diversify your portfolio, or learn more about investing, you must understand what you are trying to achieve to adequately plan your approach and choose the best strategies for meeting your goals.
There are many different factors to consider when choosing an options trading strategy. Some key considerations are listed below. You can check here to learn more about options trading.
Your investment time horizon
How long are you looking to hold onto your position? Are you seeking short-term gain, having a longer investment horizon, and using options as part of a more diversified portfolio strategy?
Your risk tolerance
Options trading can be hazardous, especially for beginners. Before engaging in any options trading activity, it is crucial to understand the risks involved and have the financial resources necessary to weather any market downturns without incurring significant losses.
Your expected return on investment
How much do you wish to make from each trade? This question will help inform which strategies are most suitable for your goals. For example, if you want a quick ROI of 10% or less, then short-term trades may
Your risk tolerance
How much leverage do you want to use, and are you willing to take on additional risk in exchange for potentially higher returns? Different risk management strategies offer different leverage levels; some carry the potential for more significant losses should market conditions change.
Once you clearly understand your personal investment goals, it will be much easier to choose an options trading strategy that is right for you. By following these tips and working with a knowledgeable broker or financial advisor, you can learn how to achieve your objectives while minimising your risks and maximising your chances to do well. You can become a successful options trader with time, patience, and a well-planned approach.
Additionally, it’s crucial to consider market conditions and trends when you begin trading options. More aggressive strategies may be more successful in bull markets, while conservative strategies may better suit market volatility or uncertainty periods.
The two categories of options trading objectives
There are two broad categories of options trading objectives: directional and non-directional. With a directional strategy, your goal is to profit from movements in the underlying asset. A non-directional strategy is intended to generate income by selling options rather than buying them for speculation purposes.
Options trading strategies
Many different trading strategies within each category can help you achieve your objectives. Some common examples include;
Covered calls are where you purchase shares in a company and then write call options against them. Straddles and strangles, where you simultaneously buy and sell options, providing a hedge against market volatility. A Butterfly spread trading strategy aims to take advantage of changes in volatility or time, and credit spreads where your goal is to earn guaranteed income rather than making a directional bet on the underlying asset. What are the risks associated with trading listed options?
Options trading can be risky, and it’s essential to understand the risks involved before beginning to trade. Some critical risk factors associated with options include limited control over your trades, unlimited losses, and high leverage levels that can magnify gains or losses. Before engaging in any options trading activity, taking proactive steps to manage these risks and protecting your portfolio is crucial.
Some best practices for reducing risk when trading options include setting clear investment goals, doing your research on potential trades, diversifying your portfolio with a variety of strategies and assets, seeking guidance from experienced traders or financial professionals whenever necessary, being patient and disciplined with your investments, and maintaining realistic expectations about potential returns.
Final thought
Whether you are looking to achieve short-term gains or long-term growth, options trading can be a powerful tool for investors looking to do well in the market and minimise risk. With the right approach and a solid commitment to taking intelligent risks, you can learn how to achieve your trading objectives while minimising your risks and taking advantage of opportunities that show up.


Start Small
As a startup, you might have other priorities when setting your business
For that reason you can start with small practices, like selecting a recycling or energy saving programme in your office
As you grow, you can increase your efforts in implementing CSR practices
Think locally
Try to align your company activity with local issues. For example, you can support a movement that encourages sustainable farming in urban areas or join school feeding schemes.
Listen to Your Staff and Customers
Your employees have the closest opinion and experience about your business, by engaging with them and following their opinion you will achieve a successful implementation of CSR within your business.
Identify the causes that matter
In other words, ask yourself what is the core of your business and then find the causes related to CSR that are linked to it
Additionally, ask your employees, working in an environment where their interests are covered, will help them to stay motivated


Establishing conditioned reinforcers in individuals with developmental disabilities: comparison of the stimulus-stimulus pairing procedure and the discriminative control procedure Date2014 Author
Schnerch, Gabriel
MetadataShow full item record Abstract
Individuals with developmental disabilities may be sensitive to a limited number of conditioned reinforcers. Therefore, the development of effective procedures to establish conditioned reinforcers in this population is of major practical importance. However, therapeutic procedures targeting the acquisition of novel conditioned reinforcers have not been extensively evaluated in the applied literature. Stimulus-stimulus pairing, a procedure consistent with a Pavlovian conditioning paradigm, has demonstrated inconsistent results. A second alternative suggests that stimuli may be conditioned as reinforcers due to their role as discriminative stimuli during operant responding. In Experiment 1, I evaluated the level of conditioned reinforcement produced by these two methods. For four of the five participants of Experiment 1, both procedures induced levels of responding above the baseline range. However, the effects were often variable and delayed. Only one participant showed differentiated levels of responding across procedures. Experiment 1 did not explore the mechanisms involved in conditioned reinforcement. Therefore, in Experiment 2 I examined the effects of satiating the primary (unconditional) reinforcers, which could reveal the learning principle involved. Experiment 2 also demonstrated the acquisition of conditioned reinforcers through both procedures. However, the satiation manipulation did not significantly change the levels of operant responding established through conditioned reinforcement, which would be consistent with a Pavlovian hypothesis.


Although working during the pandemic poses its own difficulties, this should not be an obstacle to upskilling and reskilling a company’s employees. Effective digital transformation can depend on digital learning. However, the investment can be costly when employees don’t fully utilize the online training available to them. In this article, AMPOS identifies its three key stages of developing successful employee training software, while considering organizational goals.
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In his paper ‘Miracles: metaphysics, physics, and physicalism’,1 Kirk McDermid appears to have two primary goals. The first is to demonstrate that my account of how God might produce a miracle without violating any laws of nature is radically flawed. The second is to suggest two alternative accounts, one suitable for a deterministic world, one suitable for an indeterministic world, which allow for the occurrence of a miracle without violation of the laws of nature, yet do not suffer from the defects of what McDermid terms the ‘Larmerian’ model. I briefly describe my model, reply to McDermid's criticism of it, and evaluate his alternative accounts.


A qualitative evidence synthesis to explore healthcare professionals' experience of prescribing opioids to adults with chronic non-malignant pain Toye F., Seers K., Tierney S., Barker KL.
© 2017 The Author(s). Background: Despite recent guidelines suggesting that patients with chronic non-malignant pain might not benefit, there has been a significant rise in opioid prescription for chronic non-malignant pain. This topic is important because an increasing number of HCPs are prescribing opioids despite very limited evidence for long-term opioid therapy for chronic non-malignant pain outside of end-of-life care. To better understand the challenges of providing effective treatment, we conducted the first qualitative evidence synthesis to explore healthcare professionals' experience of treating people with chronic non-malignant pain. We report findings that explore healthcare professionals' experience of prescribing opioids to this group of patients. Methods: We searched five electronic bibliographic databases (Medline, Embase, CINAHL, PsychINFO, AMED) from inception to November 2015 and screened titles, abstracts and full texts of potential studies. We included studies in English that explored healthcare professionals' experience of treating adults with chronic non-malignant pain. Two reviewers quality appraised each paper. We used the methods of meta-ethnography developed and refined for large reviews, and the GRADE-CERQual framework to rate confidence in review findings. Results: We screened 954 abstracts and 184 full texts, and included 77 studies in the full review. 17 of these 77 studies included concepts that explored the experience of prescribing opioids. We abstracted these concepts into 6 overarching themes: (1) Should I, shouldn't I? (2) Pain is Pain; (3) Walking a fine line; (4) Social guardianship; (5) Moral boundary work; (6) Regulations and guidelines. We used the GRADE-CERQual framework to evaluate confidence in findings. A new overarching concept of 'ambiguity' explains the balancing required around the factors taken into account when prescribing opioids. Managing this ambiguity is challenging and these findings can inform healthcare professionals dealing with these decisions. Conclusions: This conceptual model demonstrates the complexity of making a decision to prescribe opioids to someone with chronic non-malignant pain. Although opioid prescription is underpinned by the therapeutic aim of alleviating pain, this aim may be misplaced. This has implications for education in light of the new regulations for opioid prescription. Findings also demonstrate that the decision is influenced by intra- and interpersonal factors and broader external concerns.


The global digital forensics market size was valued at USD 1.72 billion in 2018 and is expected to expand at a CAGR of 12.3% over the forecast period. Increasing cases of sophisticated digital crime coupled with rising security concerns across various industries, such as financial institutions, IT and telecom, and retail, among others are expected to drive the market growth. Furthermore, the emergence of the Internet of Things (IoT) and increasing use of smartphones, computers, tablets, and other electronic devices is anticipated to further contribute to the growth.
Rising adoption of cloud services and devices with in-built IoT has given a leeway to cybercriminals to exploit technological limitations and gain access to customer information. Increased risk of viruses and malware, allows hackers to gain access to customer information. Rising use of electronic devices along with rising penetration of the internet gives hackers easy access to customer data, such as emails, messages, and financial transactions, among others. These factors are expected to drive demand for digital forensics to investigate financial frauds and cyberattacks.
Enterprises across the globe are focusing on the digitization of data. Sharing this large volume of data in an internal and external environment has made enterprises vulnerable to cybercrime. Cyberattacks adversely affect the enterprises in terms of data breach and revenue loss and create a dent on the brand and reputation. For instance, according to the Cyber Security Breaches Survey 2019, commissioned by Department for Digital, Culture, Media and Sport, U.K., 32% businesses and 22% charities in U.K. experience data breaches or cyber-attacks. Thus, the growing vulnerability of enterprises to cyberattacks has led to high demand for digital forensics solutions and services.
To counter rising cyberattacks, various universities and government facilities are emphasizing on organizing workshops for demonstrating digital forensics and cybercrime investigation tools. For instance, in May 2019, Cybercrime Programme Office of the Council of Europe (C-PROC) along with the University College Dublin Center for Cybersecurity and Cybercrime Investigation (UCD CCI) organized FREE TOOL Showcase Workshop in Romania. The workshop demonstrated tools for live data forensics, encryption detection, memory analysis, and open-source intelligence gathering. Such initiatives are instrumental in increasing awareness about the benefits of digital forensics.
However, significant cost incurred in installing and licensing digital forensics solutions and services is expected to pose a challenge to the market growth. Also, the rising usage of proprietary operating systems and the high level of encryption used in the new smartphone apps are other factors that may hinder the market growth. Lack of technical expertise among digital investigators and lack of pre-planning to deploy digital forensics solutions and services among the enterprises are further anticipated to thwart the market growth. Furthermore, the lack of availability of cloud forensic tools may hinder the growth of the market to investigate cloud-based frauds.
Based on components, the digital forensics market is segmented into hardware, software, and services. The services segment is further bifurcated into professional services and managed services. The software segment accounted for a significant market share in 2018 as it minimizes processing time and also detects fraud and theft based on evidence. Digital forensic software allows a user to understand the trends related to the relevant data, fluctuations in data, and to analyze potential risk factors.
Digital forensic software enables users to quickly search, identify, and prioritize the evidence, through mobile devices and computers. Also, the companies are focusing on developing flexible digital forensic software, which can gather data from various mobile devices. For instance, EnCase Forensic, a flexible digital forensic solution offered by OpenText Corp, can gather data from GPS, smartphones, and tablets, among other mobile devices. The development of such flexible software digital investigation is further expected to propel the segment growth.
The computer forensics segment dominated the market in terms of revenue with USD 555.8 million in 2018. Increasing the adoption of computer forensics in both criminal and private law investigation to inspect and recover data related to computer crime is expected to drive the segment growth. Furthermore, increased organizational spending on improving information technology for computer and network security is expected to propel the segment growth over the forecast period.
Technological advancements have strengthened the sophistication of attacks on digital devices, such as laptops and computers. The computer forensics solution deals with the collection, identification, analysis, and reporting of evidence found on such devices. Computer forensics is widely accepted as a reliable investigation tool within the European and U.S. court system to recover deleted files from the computer, live analysis, and cross-drive analysis. These solutions can extract device information, calendar events, contacts, messages, and also metadata, which is important for digital investigations.
The forensics data analysis segment dominated the market in 2018 and is expected to maintain its dominance over the forecast period. This tool offers retrieval and recording competences with deep analysis competences through metadata to offer better visibility of data risks. Increasing incidences of financial crimes and rising demand to investigate structured data for financial crimes is further driving the segment growth.
The data acquisition and preservation segment are expected to witness remarkable growth over the forecast period. The primary part of a forensic investigation is to safely obtain the evidence and preserve it without making any damage to the integrity of the data. The data acquisition and preservation tool provide the functionality to preserve the obtained evidence. The tool also provides functionality to preserve digital evidence at a secure physical site so that the original data cannot be changed or modified.
The government was the leading end-use segment in 2018 accounting for a high revenue share. This dominance can be attributed to the increasing adoption of digital forensics solutions in court systems. The government vertical is the most vulnerable segment to cyberattacks. Cyberattacks on government verticals are usually for political gains, for regional rivalry, and terrorism, among others. For instance, in August 2019, The Texas Department of Information Resources (DIR) stated that 23 government agencies in Texas witnessed a cyberattack. To deal with such incidence, the government agencies are now focusing on adopting digital forensics solutions and services.
Criminals use advanced technology to attack financial institutions and steal funds. For instance, in 2018, 54% of total fraud cases registered in the U.K. were cyber-related. Increasing the incidence of breaking bank databases and stealing customer information are major factors expected to drive demand for digital forensics solutions in the BFSI segment. Furthermore, financial institutions have now digitalized their business functions, which increases the need to opt for cybersecurity. Digital forensic is one such tool BFSI prefers to avoid financial frauds and conduct a fraud investigation.
North America dominated the market in 2018 and was valued at USD 667.0 million. This steady regional demand can be attributed to growing instances of cybercrimes and the need to follow various compliances proposed by the government for the protection of organizational data. Banks in the U.S. such as the Citigroup, Bank of America, Wells Fargo, and JPMorgan Chase, have confronted cyberattacks that led to exposed data of their consumers. These banks were recommended by the government authorities to screen their network activities. Such government impositions are further expected to drive regional market growth.
Presence of major market players such as FireEye Inc.; Access data; OpenText Corp; and LogRhythm Inc.; among others is expected to propel the demand for digital forensics in North America. Furthermore, increasing penetration of the internet and electronic devices in the region is anticipated to drive the growth. Rising technological advancements in the forensics department and development of advance theft mechanisms are encouraging public as well as public sectors to invest in the market, providing lucrative revenue generation opportunities for established players as well as new entrants to gain greater market share.
Guidance Software Inc.; LogRhythm Inc.; Access data; Paraben Corporation; FireEye Inc.; Digital Detective Group Limited; MSAB; and Oxygen Forensics Inc.; are some of the key market players. Most players heavily invest in R&D activities to drive product innovation and boost the value of their offerings. For instance, in 2018 OpenText Corporation invested USD 926 million in R&D activities.
The market players focus on initiatives, such as product updates and new product launches, to stay competitive in the market. For instance, in November 2018, Paraben Corporation launched Version 2.0 of the E3 Platform, a digital forensic tool. The platform includes features, such as Python SDK allowing customers to develop their scripts of the E3 Platform. The developed scripts are expected to support the latest mobile operating system.
The base year for estimation
2018
Actual estimates/Historical data
2015 - 2017
Forecast period
2019 - 2026
Market representation
Revenue in USD Billion and CAGR from 2019 to 2026
Regional scope
North America, Europe, Asia Pacific, Latin America, and MEA
Country scope
U.S., Canada, Germany, the U.K., India, Japan, China, and Brazil
Report coverage
Revenue forecast, company ranking, competitive landscape, growth factors, and trends
15% free customization scope (equivalent to 5 analyst working days)
If you need specific information that is not currently within the scope of the report, we will provide it to you as a part of the customization
This report forecasts revenue growth at global regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2015 to 2026. For this study, Grand View Research has segmented the global digital forensics market report based on component, type, tool, end-use, and region:
Component Outlook (Revenue, USD Million, 2015 - 2026)
Hardware
Software
Service
Professional Services
Managed Services
Type Outlook (Revenue, USD Million, 2015 - 2026)
Computer Forensics
Network Forensics
Mobile Device Forensics
Cloud Forensics
Tool Outlook (Revenue, USD Million, 2015 - 2026)
Data Acquisition & Preservation
Forensic Data Analysis
Data Recovery
Review & Reporting
Forensic Decryption
Others
End-Use Outlook (Revenue, USD Million, 2015 - 2026)
Government
Banking, Financial Services, and Insurance (BFSI)
IT & Telecom
Retail
Healthcare
Others
Regional Outlook (Revenue, USD Million, 2015 - 2026)
North America
The U.S.
Canada
Europe
U.K.
Germany
Asia Pacific
China
India
Japan
Latin America
Brazil
MEA
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Artificial Intelligence (AI), Virtual Reality (VR), and Augmented Reality (AR) solutions are anticipated to substantially contribute while responding to the COVID-19 pandemic and address continuously evolving challenges. The existing situation owing to the outbreak of the epidemic will inspire pharmaceutical vendors and healthcare establishments to improve their R&D investments in AI, acting as a core technology for enabling various initiatives. The insurance industry is expected to confront the pressure associated with cost-efficiency. Usage of AI can help in reducing operating costs, and at the same time, can increase customer satisfaction during the renewal process, claims, and other services. VR/AR can assist in e-learning, for which the demand will surge owing to the closure of many schools and universities. Further, VR/AR can also prove to be a valuable solution in providing remote assistance as it can support in avoiding unnecessary travel. The report will account for Covid19 as a key market contributor.


We have known natural essential oils as compounds extracted from the plant parts. The way these essential oils are extracted is very important, as they involve natural compounds and are not obtained from any chemical processes.
There are about more than 90 types of natural essential oils that are used in the homemade cosmetics industry, the perfume industry, and what not. Nowadays, when more people are moving towards the healthy and naturalistic use of everything, the application of these oils have been increased in homemade cosmetics. These oils supply the skin with the precious nutrients that are not harmful to health but nourish it.
Importance of Essential oils in Cosmetics
Essentials oils and cosmetics are a perfect blend together because the oils consist of a lot of anti-inflammatory and antiviral properties that are very safe to apply on skin. So Why not it can be used as an ingredient in cosmetics. This is where it all started. Being served as a natural preserving agents, essential oils have a positive effect on the human organism.
It is always important to notice the quality of the essential oils used in cosmetics. Because not all essential oils can be used. The user should have to be cautious as only pure essentials oils have positive effects on the skin. So unnecessary selection of the oil may lead to irritation or even allergic reactions.
The fragrance of the oil affects the limbic system in the brain. Therefore, some of these oils have a mood-enhancing effect too.
When cosmetics are applied on the skin containing natural essential oil in it, individual molecules are transported into the bloodstream where they integrate with the cell membrane. This further helps in the renewal of the new cells while stimulating the metabolic process.
Application of essential oils in cosmetics
Firstly, it is always advised to avoid essentials oils coming into contact with mucus membranes and eyes. Also, avoid using these oils in their undiluted state. So it is best if you use it in the form of an ingredient in cosmetics. However, the concentration level should not exceed 0.5%. Use wisely these oils and do not forget to wear protective clothing such as gloves while working with it.
The following people should avoid essentials oils as this may lead to allergic reactions:
Babies and children allergic-people People prone to epilepsy High-blood pressure sufferer Elderly people with a weak immune system What Essential Oil is suitable for skin?
For Normal Skin: It is best to use Lavender essential oil, Rose essential oil, and Rose Geranium essential oil.
For oily skin: Cistrose essential oil, Myrtle essential oil, Vetiver essential oil. For acne akin: Manuka essential oil, Myrrh essential oil, and Tea-tree essential oil is effective. For dry skin: Carrot Seed essential oil, Incense essential oil, Linaloe essential oil, Rose essential oil is beneficial. For irritated skin: Yarrow essential oil, Benzoin Siam essential oil, and Patchouli essential oil is suitable.
If you see any allergic reaction, stop using the cosmetic with that particular essential oil. And consult your dermatologist. Every essence of Natural essential has some effect. be it positive or negative.


Immediate Decrease of Muscle Biomechanical Stiffness following Dry Needling in Asymptomatic Participants Authors: Joseph P.Kelly PT, PhD, 1, Shane L.Koppenhaver PT, PhD, 2, Lori A.Michener PT, ATC, PhD, 3, Morey J. Kolber PT, PhD, 4, Joshua A.Cleland PT, PhD 5 Affiliations: Bradley University, Peoria, IL, US Baylor University, Waco, TX, US & South College, Knoxville TN, US Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, US Nova Southeastern University, Fort Lauderdale, Florida, US Franklin Pierce University, Manchester, New Hampshire, US Journal: Journal of Bodywork and Movement Therapies - April 2021, Volume 27, Pages 605 - 611 (DOI: 10.1016/j.jbmt.2021.04.014) Medical Musculoskeletal disorder Musculoskeletal rehabilitation Treatment evaluation Myofascia Field & Applications: Background: Biomechanical muscle stiffness has been linked to musculoskeletal disorders. Assessing changes in muscle stiffness following DN may help elucidate a physiologic mechanism of DN. This study characterizes the effects of dry needling (DN) to the infraspinatus, erector spinae, and gastrocnemius muscles on biomechanical muscle stiffness. Method: 60 healthy participants were randomized into infraspinatus, erector spinae, or gastrocnemius groups. One session of DN was applied to the muscle in standardized location. Stiffness was assessed using a MyotonPRO at baseline, immediately post DN, and 24 hours later. The presence of a localized twitch response (LTR) during DN was used to subgroup participants. Results: A statistically significant decrease in stiffness was observed in the gastrocnemius, the LTR gastrocnemius, and the LTR erector spinae group immediately following DN treatment. However, stiffness increased after 24 hours. No significant change was found in the infraspinatus group. Conclusions: DN may cause an immediate, yet transitory change in local muscle stiffness. It is unknown whether these effects are present in a symptomatic population or related to improvements in clinical outcomes. Future studies are necessary to determine if a decrease in biomechanical stiffness is related to improvement in symptomatic individuals.
Keywords: Dry needling, myofascial trigger point, muscle stiffness
The direct relationship of increased muscle stiffness and injury is not well established and poorly understood. The increased stiffness of MTrPs could impact the performance of the muscle and may contribute to localized trauma. DN may provide immediate, but temporary decrease in stiffness. Clinical observation of LTR combined with measurement of biomechanical stiffness may be a beneficial biomarker for successful DN outcomes, but requires further investigation.


A common question I receive about trauma insurance is “How do I keep it affordable, especially as I get older.?”
As a reminder, trauma insurance will pay you a lump sum if you have a major illness or accident. It provides your payment that is free of taxes. However, the issue with trauma insurance is that it can become quite expensive, especially as you get to my age.
You could consider restructuring the policy, so it provided a combination of standard and severe trauma cover. A severe trauma policy covers the majority of the same conditions covered under a standard trauma policy and in some cases identical criteria. I’ve used that for some conditions, but more severe criteria are used for a claim to be considered. The advantage of focusing on the policy covering you for more severe conditions is that it can result in a significant reduction in what you pay for your trauma cover. Because severe trauma cover is priced significantly lower than the standard trauma cover.
If you have any other questions about this or any other insurance-related matter, please contact me, adrian@adrianschwartz.com.


PRESS RELEASE
November 04, 2014: Descartes, the global leader in uniting logistics-intensive businesses in commerce, announced that Gist, a leading supply chain services provider, has expanded its use of Descartes Smartanalysis, a tachograph analysis and compliance management solution, across its European road transport operations.
"We've been using Descartes Smartanalysis for over four years in the UK with more than 1,000 heavy goods vehicles and 2,000 drivers," said Ken Clarke, Head of Transport Operations in Europe for Gist.
"Before using Descartes, managing compliance for our large and widely dispersed fleet in Europe was a time-consuming and labour-intensive operation for Gist. By extending our use of Smartanalysis to include the Netherlands, Austria, Italy, Czech Republic, France and Scandinavia, we can drive additional efficiencies in our business."
The European Union is continuing its efforts to harmonise the enforcement of legislation regarding tachograph data and drivers' hours across member states to promote road safety and ensure a level competitive landscape between commercial road transport operators.
As part of Descartes' Smart Compliance suite designed to address these regulations, Descartes Smartanalysis is a cloud-based tachograph analysis solution that helps road transport operators with fleets of all sizes, like Gist, meet legal obligations with regard to drivers' hours, working time, and tachograph regulations. It also has capabilities to verify that drivers hold a valid driving licence and to access tachograph data, analysis and reports via the Internet.
"As enforcement efforts increase across Europe, leading transport operators such as Gist are more proactively managing their compliance," said Steve Fisher, Managing Director of Descartes UK. "By using Descartes Smartanalysis for its European operations, Gist has enhanced its compliance capabilities, allowing it to be more focused on running its core business and better serving customers."
Gist provides innovative bespoke supply chain solutions that deliver cost savings, environmental benefits and competitive advantage. Gist Limited is a supply chain company with a history spanning over 100 years. They have over 3,000 customers from a wide range of commercial and industrial sectors including market leaders such as Marks & Spencer and Starbucks.


As noted by Dr. Stanley and Dr. White in this week’s media presentation, professional nurses should be engaging in advocacy efforts to improve health and nursing practice through involvement in the policy process at the institutional, local, state, or federal levels. This array of possibilities for involvement provides opportunities for all nurses, regardless of time, or other possible constraints. Successful policy making is a collaborative effort, and one that commands mutual respect from all involved. Your involvement in policy making can lead to expanded opportunities as both a nurse leader and as a respected member of an interprofessional health care team.
Note: This Discussion provides a forum for discussing advocacy opportunities and honing your presentation skills in a small group setting. To prepare: Reflect on the insights offered by Dr. Stanley and Dr. White on engaging in advocacy through the policy process. Identify a practice issue that is of interest to you and that could benefit from advocacy efforts through the policy process. Consider the stakeholders and any special interest or professional organizations that would support your issue. Develop a short, yet persuasive PowerPoint (up to 3 slides IN APA FORMAT) as follows:
1) Identify the practice issue that would benefit from being addressed through the policy process
2) Represent the key stakeholders (i.e. use graphical images when possible)
3) Propose one strategy for how a nurse could advocate for this issue
The PowerPoint should be succinct, visually appealing, and effective.


Customizing your house is one of the most exciting parts of homeownership, as you can transform the space into the perfect home for your family. However, some major projects may backfire if the property value stays the same or decreases after making your improvements. Here are a few projects that don’t add value to a home. If a good return on investment is important, you might want to rethink these updates.
Projects That Don’t Add Value: Luxury Kitchen and Bathroom Upgrades
If you love cooking elaborate meals for your family or enjoy long soaks in a spa-sized bathroom, you likely will appreciate luxury kitchen or bathroom renovations. However, don’t expect the cost to reflect in the house’s value.
Many potential buyers won’t see value in high-end kitchen appliances or a spa tub and luxury shower in a large bathroom. For a better return on investment, focus on more straightforward upgrades like fresh paint, new energy-efficient appliances, hardwood flooring, or a kitchen island.
Installing a Hot Tub or Swimming Pool
Homeowners who love to entertain friends during the summer or spend money on frequent visits to the pool or waterpark might consider installing a pool. While that may seem like a good idea, pools involve costly upkeep and maintenance. You’ll be responsible for establishing and maintaining a pool fence, water treatment chemicals, and regular pool cleaning. Some buyers want a pool, but most are not interested in the constant attention that a swimming pool or hot tub requires.
Outdoor Projects That Don’t Add Value
Landscaping and hardscaping home improvement projects are costly and require ongoing maintenance and care to keep them attractive and functional. Features that add to your enjoyment, like a fountain or gazebo, are more work and responsibility for prospective homebuyers.
Let’s look at ways you can boost the value of your property on the outside.
Hire a professional landscaping company to care for your lawn, edge your garden beds, and handle tricky tasks like pruning. Add fresh mulch around the base of trees and shrubs. Install a patio or deck. Plant trees a safe distance from the home. Use landscape lighting to highlight architectural features and improve the safety of walkways and your home’s security. Design and construct a fire pit in the backyard. Custom Closet Remodels
Walk-in closets are a feature that many homebuyers expect. However, there is a difference between a versatile walk-in closet and a custom closet that cuts into square footage with dressing areas, built-in shelving, and oversized mirrors that only appeal to a specific type of buyer. Closet remodels can easily cost five figures on average, and your home’s value will only raise a small fraction.


OFFSHORE TRUST
Why High Net Worth Client Need Offshore Trust ?
Offshore trusts are frequently regarded by High-Net-Worth (HNW) clients as the pinnacle of efficient tax and estate planning, providing them with numerous opportunities to reduce taxes and protect assets for beneficiaries while potentially retaining significant control, particularly for those owning global businesses or real estate.
Why Offshore Trust Give Asset Protection ? Offshore trusts are a type of asset protection tool that entails establishing a trust or business entity in a favourable legal jurisdiction outside of your home country. Offshore assets are placed under the control of trustees or managers who are located outside of your home country and manage your estate after your death. People with both significant assets and higher risks of legal liability can establish offshore “asset protection trusts” to avoid legal battles from creditors in jurisdictions beyond the reach of their residing country’s courts.


Ninety-seven per cent of Philippine companies (around 50,000 firms) have complied with providing holiday pay to their employees in the first nine months of this year, according to the Department of Labor and Employment (DOLE).
During a Laging Handa briefing, DOLE’s Policy and Program Development Division Chief Nicanor Bon confirmed that the compliance rate reached as high as 97%. However, over 1,400 firms failed to comply with the measure.
Bon also stated that businesses that stopped their operations during the lockdowns are exempted from the policy.
Under the labor department’s rules, employees who reported to their companies during regular holidays shall be paid 200% of their regular salary for the first eight hours of work. Those who did not go to work shall still receive 100% of their salary for that day.
Special conditions are also applied to workers who worked overtime or had their rest day fall on a regular holiday.
Bon added that the public may report to DOLE offices, call the DOLE Hotline 1349, or go to the DOLE website to report establishments that have not paid the holiday pay of their workers.


Over a 10-year period, self-storage real estate investment trusts have exploded, earning annual returns north of 19.1%, as SPGlobal reports. While there are many REIT sectors, including mortgage, industrial, healthcare, pure leasing and more, self-storage has the highest 10-year returns.
The increase in self-storage can be attributed to the needs of younger generations, such as millennials, looking for extra storage as they cramped in their apartments. Not to mention, many retirees who travel may find it more cost-effective to have a storage unit and a smaller home in their hometown.
Also read: 2 Industrial Equity REITs With Higher Than Average Yields National Storage Affiliates reports that for the past 28 years since 1994, self-storage REITs saw an average 18.8% return. Here are two for investors to consider. National Storage Affiliates Trust NSA With a strong track record of increasing its dividend for six consecutive years, using quarterly payments, is offering a dividend yield of 5.81% annually, or $2.20 per share. National Storage Affiliates is a real estate investment trust that owns, operates, and acquires self-storage properties located within metropolitan statistical areas throughout the United States.
National Storage is currently one of the largest owners and operators of self-storage facilities in the US and operates 1,100 self-storage properties with approximately 71.5 million rentable square feet in 42 states and Puerto Rico as of September 30, 2022. does.
National Storage has seen 900% growth since the formation of its multi-faceted acquisition strategy, primarily due to joint ventures and third-party acquisitions.
global self storage yourself Paying quarterly, with a rare track record of increasing its dividend payments, is offering a dividend yield of 5.84% annually, or 29 cents per share. Global Self Storage is a self-governing and self-managed real estate investment trust that owns, operates, manages, acquires, develops and redevelops self-storage properties for residential and commercial clients.
Global Self Storage currently has 13 self-storage properties with a total of 968,563 square feet in several states including Connecticut, Illinois, Indiana, New York, Ohio, Oklahoma, Pennsylvania and South Carolina.
Global Self Storage’s strategic plans for growth include acquisitions directly or through joint ventures and expansion projects on existing assets.
To read about the latest developments in the industry, visit Benzinga’s real estate homepage


Abstract
Background:: Hemorrhagic shock causes hypoperfusion of peripheral tissues and promotes endothelial dysfunction, which may lead to further tissue injury. Trauma increases extrahepatic activity of arginase, an enzyme which competes for l-arginine with nitric oxide synthase, and plays a key role in the development of endothelial dysfunction during aging, hypertension, and diabetes. However, the role of arginase in hemorrhage-induced endothelial dysfunction has not been studied. This study tests the hypothesis that arginase inhibition improves endothelial function after hemorrhage. Methods:: Male Sprague-Dawley rats were implanted with indwelling arterial catheters for blood pressure measurements and blood removal. Awake animals were subjected to a 45% fixed volume controlled hemorrhage and blood pressure was monitored. Unbled rats served as controls. Skeletal muscle arterioles were isolated 24 hours after hemorrhage and cannulated in a pressure myograph system. To study endothelial function, arterioles were exposed to constant midpoint, but altered endpoint pressures, to establish graded levels of luminal flow and internal diameter was measured. Results:: Hemorrhage lowered mean arterial pressure that spontaneously recovered to 78% and 88% of baseline in 2 hours and 20 hours, respectively. Vascular arginase II and blood glucose levels were elevated, whereas hemoglobin and insulin levels were decreased 24 hours after blood loss. In posthemorrhage arterioles, flow-induced dilation was abolished. Acute in vitro treatment with an inhibitor of arginase, N
ω-hydroxy-nor-l-arginine, restored flow-induced dilation to unbled control levels. Similarly, the arginase and nitric oxide synthase substrate, l-arginine, but not the inactive isomer, d-arginine, restored flow-induced dilation. Conclusions:: These results indicate that arginase contributes to endothelial dysfunction in resistance vessels after significant hemorrhage.
Original language English (US) Pages (from-to) 384-391 Number of pages 8 Journal Journal of Trauma - Injury, Infection and Critical Care Volume 69 Issue number 2 DOIs State Published - Aug 2010 Keywords Arginase Arginine Endothelial dysfunction Hemorrhage Shock Vascular tone ASJC Scopus subject areas Surgery Critical Care and Intensive Care Medicine


Reading the Word
“
For lack of wood the fire goes out, and where there is no whisperer, quarreling ceases.” (Proverbs 26:20, ESV) Understanding and Applying the Word
Perhaps the most damaging aspect of conflict is that it can be difficult to bring it to an end. Why is that? When we are hurt by someone else, it is natural for us to want to get even. We want to somehow inflict pain on the other person or gather others to our side so we feel justified in whatever took place. In most cases, we continue to engage in our quarrel by talking about the other person or the incident(s). As we talk to others, attitudes and actions are fed and the conflict continues.
Proverbs 26:20 reminds us that if we stop feeding a fire, it will go out. The same is true of quarreling. If we stop adding to the conflict, it will often fade away. We can do this by choosing not to talk poorly about the other person and by being careful with our actions. Conflict is difficult, but we only make it more difficult when we continue to engage in it. We need to learn to stop adding fuel to the fire.
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