This paper presents an alternative to the constituent power theory (CPT), which it terms as a theory of elite democratic bargaining (TEDB). According to TEDB, constitution-making and reform must be based on a bargain between different elite groups in society – controversially not excluding discredited, displaced, or authoritarian elite groups. Using TEDB instead of CPT as a baseline to assess the legitimacy and legality of constitution-making and reform can serve as a better framework for all seasons and aligns with the practical realities of modern constitution-making and reform, which depend predominantly on elite negotiations. Though TEDB can make constitutional changes arduous and moderated, and by its heightened focus on elites, poses tough philosophical questions, this paper will argue how the net benefits of TEDB in building a stable democratic society might warrant its consideration as a viable alternative to CPT.
We look forward to welcoming you on July 3-5, 2023 for our Annual Conference entitled "Islands and Ocean: Public Law in a Plural World." The conference will take place at the Victoria University of Wellington, in New Zealand. We will be announcing more details about the conference soon, including financial support to early career and global south scholars!


Department of Physiology, University of Kentucky, Lexington, USA. laura.ashley@uky.edu
Fatigue is one of the most common symptoms of cancer and its treatment, manifested in the clinic through weakness and exercise intolerance. These side effects not only compromise patient's quality of life (QOL), but also diminish physical activity, resulting in limited treatment and increased morbidity. Oxidative stress, mediated by cancer or chemotherapeutic agents, is an underlying mechanism of the drug-induced toxicity. Nontargeted tissues, such as striated muscle, are severely affected by oxidative stress during chemotherapy, leading to toxicity and dysfunction. These findings highlight the importance of investigating clinically applicable interventions to alleviate the debilitating side effects. This article discusses the clinically available chemotherapy drugs that cause fatigue and oxidative stress in cancer patients, with an in-depth focus on the anthracycline doxorubicin. Doxorubicin, an effective anticancer drug, is a primary example of how chemotherapeutic agents disrupt striated muscle function through oxidative stress. Further research investigating antioxidants could provide relief for cancer patients from debilitating muscle weakness, leading to improved quality of life.
Laura A A Gilliam, Daret K St Clair.Chemotherapy-induced weakness and fatigue in skeletal muscle: the role of oxidative stress.
Antioxidants & redox signaling.2011 Nov 1;15(9):2543-63
PMID:
21457105


This study investigated the orientation dependence of myelin water fraction (MWF) as evaluated with a 3D multiple-spin echo sequence (MSE). MSE and diffusion tensor scans were acquired at 7-T from two excised rat brains at three different orientations with respect to the main magnetic field. Region of interest analysis of the corpus callosum and the internal capsule revealed that there is no clear orientation dependency for MWF in these white matter tracts. This result is also evidenced by the minimal orientational modulation of the T
2 spectra for both ROIs across both brains.


Financial planning for business owners & real estate investors
Coordinated legal, tax, and compliance solutions.
Coordinated Advisory Services Real solutions for business owners and real estate investors
Many financial advisors stumble when it comes to businesses and real estate investments. The advice is often to liquidate these assets to free up cash to invest in the market. This may not be the right advice.
Businesses and real estate can and have produced superior results with less volatility and risk. This raises questions about advisor conflicts given that most financial advisors are paid by selling stocks, bonds, mutual funds, or insurance products.
Many fee-only financial planners focus on these traditional investments as well. They focus on asset allocation with these investments and develop retirement projections based on these assets. If you do not have a significant amount of these types of investments, they may not really be interested in helping you. You are the odd-man-out.
This is where Axiom Edge comes in. We focus on clients like you who have “non-traditional” investments.
We take a team approach. We coordinate the efforts of your existing advisors and help you invest in, manage, and grow your business and real estate investments.
Our Financial, Legal & Tax Focus
We focus on ongoing planning and advisory services. This allows us to get to know our clients and tailor our services to those clients needed today, tomorrow, and in the future.


Data qualityand data capabilities within an asset management organization is vital when addressing operational transformation. Often,data practices are an afterthought when attempting to engage in an operational transformation initiative. The reality is that organizations lacking good, clean data and solid data practices will find implementing the future state model challenging, longer than necessary and more costly to deploy.


What is an ephelis?
An ephelis is a freckle, a small, light brown or tan mark on the skin.
The plural of ephelis is ephelides. The can be hundreds or thousands of them on exposed skin.
Who gets ephelides?
Ephelides are particularly common in fair-skinned Celtic children. They are not present at birth. People with white skin that cannot tan (Fitzpatrick skin phototype 1) often have red hair and numerous ephelides. Ephelides can also occur in other races that have dark brown or black hair.
What causes ephelides?
Ephelides are an inherited characteristic. People with many ephelides have at least one copy of a variant MC1R gene, which is the same variant that causes red hair. Freckles in non-Caucasians are associated with a different variant of the gene.
The pigment-forming cells, melanocytes, produce more pigment than usual in ephelides. The pigment is packaged as melanosomes and distributed to surrounding keratinocytes.
Ephelides increase in number following exposure to ultraviolet radiation in sunlight.
What are the clinical features of ephelides?
Ephelides are found on sun-exposed sites, particularly the nose and cheeks.
They are prominent during summer and fade during winter. Light to dark brown flat macules 3–10 mm in diameter Poorly defined and may merge into large patches Any shape; often round Freckles Complications of ephelides How is an ephelis diagnosed?
Ephelides are usually diagnosed clinically. However, from time to time, the diagnosis is made by a histopathologist after skin biopsy of a pigmented lesion.
An increase in pigment is noted in otherwise normal skin There is no increase in the number of melanocytes (unlike lentigines) What is the treatment for ephelides?
No treatment is necessary. Occasionally, people seek treatment for ephelides. They can be advised to protect affected areas using broad-spectrum, sun protection factor 50+ sunscreen.
Cosmetic camouflage can be applied to disguise ephelides Pigment laser treatment may result in temporary lightening of the freckles How can ephelides be prevented?
As they are an inherited characteristic, they cannot be prevented. However, the summer darkening can be reduced by careful sun protection.
What is the outlook for ephelides?
Ephelides are particularly prominent in children. They often become less obvious in adult life.


Usually, we buy water heaters once in a long while. Either when we build a new home and are shopping for a water geyser for it or when our current water heater is faulty and needs replacement.
Therefore, given that we utilize water heaters for several years before finally getting another opportunity to replace them, it would be best to choose wisely.
Here are six factors to consider before buying a
water geyser. 1. Type Of Water Heater
Different water heaters fall into these five general categories:
Conventional storage water heaters: These come equipped with a storage tank or reservoir to store the hot water required for everyday use. Tankless water geyser: These tanks heat water directly on demand without using a storage tank. Heat pump water heaters: Instead of directly heating the water in a tank, this type of water heater transfers heat from one place to another. Result? A significant reduction in heating costs and higher efficiencies. Solar water heaters: These heaters rely on the sun’s heat to provide hot water, thus resulting in cheaper energy bills. Solar water heaters are ideal in hot areas due to the abundance of sunlight and heat. Indirect and tankless coil water heaters: These kinds use your home’s space heating system to provide hot water. 2. Fuel Source
Residential water heaters usually use either electricity or gas as their fuel source. Gas-fired water heaters might be categorized into propane or natural gas water heaters.
They require special ventilation for safety and health purposes. However, one advantage of gas models is that they have lower operating costs. The low cost allows you to offset their initial higher up-front costs.
Electric water heaters may initially cost less but have higher operating and water heater repair costs, which will cost you more in the end.
3. Energy Efficiency
Next to the HVAC system, the water geyser is one of the largest consumers of energy in the home. Prudently select a water heater with higher energy efficiency.
4. Type of storage
As mentioned earlier, water heaters can either have storage tanks or are tankless. The heaters with storage tanks continually heat and store hot water.
They release hot water from the top of the tank while letting in cold water from the bottom to replace the used water, thus ensuring that the tank is always full.
The tankless water heaters (also known as on-demand water heaters) direct cold water into a unit and heat it as needed. These tankless water heaters also ensure that the hot water never runs out.
However, in a large household, where several people require hot water at once, the limited flow rate typical of tankless water heaters might bring an issue.
5. Storage Capacity
Depending on the family size and the hot water usage, you need to select a water geyser with a suitably sized tank. A large household may require more water to run the dishwasher, wash laundry, and take several showers daily.
Thus, these activities need a larger-sized water heater or a tankless water
heater. These tanks can deliver a high amount of hot water in a short time. 6. Space Required
It is also essential to ensure that the water geyser fits into a space. For instance, you can find wider and shorter boilers that can fit into areas with limited headroom, such as under cabinets.
Tankless water heaters also take up much smaller spaces when compared to traditional storage tanks.
Conclusion
When choosing your water heater, the factors above-mentioned should be enough to point you in the right direction.


The
Federal Register is a daily journal of federal government activity that includes presidential documents, proposed and final rules, and public notices. It is a common measure of an administration’s regulatory activity, accounting for both regulatory and deregulatory actions.
From June 6 through June 10, the
Federal Register grew by 1,576 pages for a year-to-date total of 35,642 pages.
The
Federal Register hit an all-time high of 95,894 pages in 2016.
This week’s
Federal Register featured the following 576 documents: 454 notices Eight presidential documents 42 proposed rules 72 final rules
Four proposed rules, including revisions to the 2020 water quality certification regulatory requirements under the Clean Water Act (CWA) section 401 from the Environmental Protection Agency, and four final rules, including an amendment to regulations to waive excess and unauthorized grazing fees as a result of unforeseen circumstances from the Forest Service Agency were deemed significant under E.O. 12866—defined by the potential to have large impacts on the economy, environment, public health, or state or local governments. Significant actions may also conflict with presidential priorities or other agency rules. The Biden administration has issued 86 significant proposed rules, 113 significant final rules, and one significant notice as of June 10.
Ballotpedia maintains page counts and other information about the
Federal Register as part of its Administrative State Project. The project is a neutral, nonpartisan encyclopedic resource that defines and analyzes the administrative state, including its philosophical origins, legal and judicial precedents, and scholarly examinations of its consequences. The project also monitors and reports on measures of federal government activity.
Additional reading:


Crime Time: How Ambient Light Affects Crime
Date
May 2019
This paper studies the effect of ambient light on crime, taking advantage of the daylight saving time (DST) policy, which imposes exogenous variations in daylight exposure at specific hours of the day. The paper uses a rich administrative database managed by Chile’s national police, a centralized agency that collects detailed information regarding each crime incident. A 20% decrease (increase) in crimes is found when the DST transition increases (decreases) the amount of sunlight by one hour during the 7-9 p.m. period. Importantly, no significant response is detected induced by DST associated with a plausible demand-side response such as the population’s commuting time pattern, and no substantial short-term displacement is found. Most of the changes in property crime due to the DST policy are driven by robbery in residential areas.


How Animal Crossing Triggered a Rape Flashback
This article discusses the theory of flashbacks, which involves a repeating traumatic event in an effort to understand what happened. A flashback is when a person experiences flashbacks. The brain recognizes similarities between the current situation, and the last time that he or she was in danger, then reacts accordingly. This theory suggests that the flashback is a way for the brain to learn how to avoid future situations and to practice life-saving behavior.
Rape is a horrible and distressing experience that becomes part of the victim’s identity. The experience can make a victim feel vulnerable, anxious and scared. These sensations can trigger flashbacks and intense feelings.


We’re shining light on the growing problem of inequality inside of tech workplaces, specifically for contract workers.
Housing technology garners venture-backed excitement, but without ethical frameworks and processes to ensure equitable housing outcomes, racial and economic inequities may abound.
We believe tech companies have the unique ability to create opportunities for those who have been previously shut out—workers who have a conviction history.


Miga Health is a heart health platform focused on preventing the next million heart attacks and strokes.https://www.migahealth.com/
Miga Health is an end-to-end vertical treatment platform for hypertension (high blood pressure) centered around the consumer. Miga was founded by Dr. Jarrad Aquirre (Yale undergrad, Rhodes Scholar, Stanford MD / MBA) and Dre Limberopoulos (previous founder of a wearable tech company and an early employee at TrialSpark) in Q4 2021.
Miga Health is a digital-first provider of hypertension-related care. Consumers sign up for a monthly subscription to Miga, and will be able to purchase add-ons (e.g., medication and quarterly lab check-ins). In return, Miga will send the consumer a free cuff for measuring blood pressure and plans to offer additional services, including a virtual community, personalized coaching, gamified collection of blood pressure (BP) readings, data shared with a PCP or physician, medication management, and fingerstick labs.
Almost half of all adults in the U.S. (>116 million) have some form of hypertension. Approximately 37 million adults have stage 2 hypertension, defined as blood pressure of 140/90 mmHg or higher, and are usually recommended to take medication along with lifestyle changes. It is estimated that approximately $130-$200 billion is spent on hypertension annually in the U.S. Expanding to include the larger cardiovascular market, it is estimated that cardiovascular issues cost the U.S. ~$360 billion annually.
Yale (BS, Biology), University of Oxford (MPhil, Medical Anthropology), Stanford University School of Medicine (MD), Stanford University Graduate School of Business (MBA)
Monash University (BSE, Bachelor of Software Engineering)
Cardiovascular disease is one of the largest and most expensive diseases in the U.S., causing 1 in 3 deaths and costing society upwards of $360 billion annually. However, ~80% of premature heart attacks and strokes are preventable. Hypertension is the foremost modifiable risk for cardiovascular disease and is highly prevalent. The current solution for treating hypertension is fragmented, inconvenient, and leaves the onus on the patient, who must actively show up in person, be diligent about recording their blood pressure daily with no short-term incentives, coordinate sporadic check-ins with their doctor, visit labs for blood tests, etc. We see Miga Health in the broader context of our theme around patient-centric disruptive solutions for chronic disease.


“Pay discrimination often is rooted in different forms of bias [and] these biases can lead to Black women being underpaid; being passed over for promotions; and being excluded from better, more lucrative jobs.
Ongoing anti-bias training is critical to combat workplace biases that devalue the contributions of Black women. Employers requiring all staff throughout the company to undertake such training on an annual basis could help counter discriminatory attitudes and create more equitable workplace environments for all workers.”
-Jocelyn Frye | President, National Partnership for Women & Families


Keywords: indigenous communities
Towards rangatiratanga in pest management? Maori perspectives and frameworks on novel biotechnologies in conservationS. Palmer, O. R. Mercier and A. King-Hunt, Pacific Conservation Biology,
11.
2020.
We gathered Maori perspectives on novel biotechnological controls for pest wasps through three distinct studies. Study participants included tertiary students, businesses, and spiritual or religiously affiliated groups. All participants drew from their identities as Maori people ...
Keywords: consent, conservation tools, gene drive synthetic, genetic biocontrol, indigenous communities, New Zealand' social license' informed-consent, wasp


The cost of living varies considerably across the nation’s metro areas. These differences are driven largely by the prices of housing, food, and transportation. For many workers in many of these metro areas, local wages reflect local differences in the cost of living, but this is less likely to be true for lower-skilled workers. This article explores the variation in the cost of living across metro areas and the implications of this variation for low-income residents. It also explores factors that deter low-income residents from migrating away from high-cost-of-living areas, and public policies that might alleviate the hardships experienced by these residents.
This article appeared in the Second Quarter 2022 issue of Economic Insights. Download and read the full issue.


During DoDIIS Worldwide, senior decision makers, technical experts, and innovators from across the Department of Defense, Intelligence Community, industry, and academia will come together to collaborate and share unique insights. The theme of this year’s conference – Transcending Strategic Competitors through Innovation, Adaptation, and Collaboration – underscores the urgent race to collectively develop and unleash emerging technologies to maintain strategic and tactical advantage. Mission success in an era of strategic competition demands a willingness to embrace disruption and elevating partnerships to serve as overwhelming force multipliers.
For 20 years, this conference has offered attendees the opportunity to hear from distinguished speakers, collaborate with trusted partners, and experience ground-breaking technical solutions to support the warfighter. This immersive in-person event is designed to bring together leading subject matter experts, decision makers, and stakeholders to forge relationships.


As the demand for Science, Technology, Engineering and Math (STEM) jobs continues to grow, companies need to focus on sustainably building equity into such opportunities. Discovery Education strategically partners with like-minded organizations, such as the Caterpillar Foundation, to deliver engaging learning experiences every single day to classrooms in the U.S. and across the world to foster more pathways for STEM careers.
Here are a few examples of how the private sector, in tandem with NGOs and the federal government, is investing in innovations focused on the end-of-life recovery of plastics.
The U.S. Chamber Foundation is pleased to announce a new sustainable plastics initiative to help us harness the full potential of plastics while ensuring we plan for their end-of-life management. This initiative will explore innovations across the plastics value chain, all the way from material science to end-of-life reuse and repurposing.
Shaping the future – and diversity – of the science, technology, engineering and math (STEM) workforce starts with education today.
In the era of COVID-19, an economic recession, and widespread social unrest, mental health is the next crisis we need to prepare for.


Digital technologies are ubiquitous in media, government, commerce and education. Educators need to be knowledgeable and critical users and creators of digital technologies. This unit introduces you to a range of digital technologies currently in use in education, discusses critically the ways such technologies can enhance learning, and examines in detail the limitations of Information and Communication Technologies (ICT). It focuses on the role of the digital world for children and emphasises the critical knowledge and skills necessary for safe, responsible and ethical use of ICTs in learning and teaching. The unit also supports student to select and use digital technologies to enhance their own learning.
On successful completion of this unit, students will be able to:
This unit is studied as part of the following course(s):


Culture, Technology, and Process in “Media Theories”: Toward a shift in the understanding of media in organizational research
Publikation: Beiträge in Zeitschriften › Zeitschriftenaufsätze › Forschung › begutachtet
Authors
The concept of ‘media’ can provide an anchor point for developing organizational theories about information and communication technologies, materiality, communication, and organizational change. However, to date, organizational research often takes the meaning of the term media for granted. This article therefore explores various conceptions of media, outlining how such theories can be used for advancing the conception of media in organizational research. Using three ideal-typical branches of conceptions of media, we explore key concerns regarding media in existing literature outside of organizational research. First, the culture and power branch problematizes how cultural practices and power structures are inscribed through media; second, the technology and infrastructure branch emphasizes the inherent ‘eigenlogik’ of media technology; and third, the process and change branch explores how existing economic and aesthetic conventions in media persist over time. Using organizational media in general and enterprise social media in particular we discuss how each of these three ideal-typical branches offer pathways for organizational research. Specifically we argue for shifting the use of the term media beyond merely describing tools for communication as media theories offer insights for understanding the long-term consequences of materiality and ontological co-constitution within sociomaterial assemblages.


Journal Articles
Buchanan, A, When Knowing What Is Just and Being Committed to Achieving it Is Not Enough,
Journal of Applied Philosophy, vol. 38 no. 5
(November, 2021),
pp. 725-735 [doi].
(last updated on 2022/12/06)
Abstract: In this article, I argue that overly-optimistic beliefs about how much progress toward justice has been made and overly-pessimistic beliefs about what progress toward justice can be made can both help perpetuate injustices. Further, such beliefs can help perpetuate injustices even if those who hold them have a firm grasp of the correct principles of justice, a robust commitment to realize them, and the political influence to make their commitment effective. I also argue that when mistaken beliefs about justice of either sort are embedded in ideologies, they are an especially serious obstacle to moral progress. Finally, I conclude that ideologies can help perpetuate injustices even if they do not ‘mask’ them, if they include either overly-optimistic or overly-pessimistic beliefs about progress toward justice.


The following is a media release from Sen. Ed Markey and Sen Elizabeth Warren’s offices. Both were elected by voters in the Commonwealth of Massachusetts to serve the state in Washington DC in the US Senate. Both are Democrats.
***
WASHINGTON DC –
Such funding would help mitigate the devastating impact that COVID-19 has had on higher education in the Commonwealth, and prevent the need for colleges and universities in Massachusetts and across the country to raise tuition costs for students or layoff workers.
There are over one hundred colleges and universities in Massachusetts — including prestigious research universities, state public colleges, private liberal arts institutions, and community colleges — that employ a significant share of the workforce in Massachusetts and serve students from communities all over the Commonwealth and around the world.
These institutions have taken unprecedented steps to respond to the global pandemic, from identifying new ways to deliver classes online and implementing necessary campus-wide closures, to helping lead the urgent search for COVID-19 treatment and a vaccine.
However, as a result of COVID-19, colleges and universities in Massachusetts — which rely on tuition-face significant losses in revenue while facing new, unexpected costs.
“COVID-19 has jeopardized the health, learning, and livelihoods of millions of vulnerable students, and threatens to further destabilize the institutions of higher education upon which our nation depends, including colleges and universities in Massachusetts,” the lawmakers wrote.
“We implore you to include vigorous financial assistance for students and higher education institutions in the forthcoming COVID-19 relief package.”
Specifically, the lawmakers asked that Congressional leaders prioritize the following measures:
Emergency aid to students: an emergency increase in grant aid to students to help students with financial need pay for things like transportation, food, and relocation assistance. The lawmakers also requested that student aid be retained regardless of COVID-19 related changes in enrollment, work status, or circumstances which would otherwise jeopardize aid eligibility. Emergency stop-gap funding for colleges and universities:robust stop-gap funding to support institutions as they deal with unprecedented disruption, lost revenue, and increased costs associated with such a rapid response to COVID-19, including costs associated with protecting and relocating students. The lawmakers argue this funding is critical to prevent tuition increases or worker layoffs. Funding support for technology:grant funding to ensure that students and institutions are supported in the transition to high-quality online learning with regular and substantive engagement with qualified faculty, while also ensuring that students do not lose access to their educations as a result of the shift.


Plant-derived materials such as cellulose often exhibit thermally insulating properties. A new material made from nanoscale cellulose fibers shows the reverse, high thermal conductivity. This makes it useful in areas previously dominated by synthetic polymer materials. Materials based on cellulose have environmental benefits over polymers, so research on this could lead to greener technological applications where thermal conductivity is needed.


Our Strategic Focus
Since the first national coaching strategy in 2004, New Zealand has always placed significant importance on the role of HP coaches in achieving international success. The emergence of performance pathways as the key strategic anchor within HPSNZ’s 2024 strategy further highlights the central role that HP coaches will play as the kaitiaki (guardian) of athlete performance pathways in New Zealand.
A recent evaluation of the current state of HP coaching across the New Zealand HP system has identified the following key priorities and desired outcomes relating to HPSNZ’s 2024 strategy.
Our 2024 Priorities Desired Outcomes 1. Retain our most successful coaches and provide tailored support designed to sustain athlete success 2. Identify the next generation of HP coaches and develop their capability with next cycle success in mind 3. Partner with NSOs to enhance system capability to lead HP coaching and upskill their coaches
For further information on our strategic focus please contact
Daragh Sheridan Ph.D.
Manager, HP Coaching, HPSNZ T: +64211958963 E:daragh.sheridan@hpsnz.org.nz


If your health could be better, and you’re becoming frustrated with your conventional doctor, you might want to consider naturopathy. Naturopaths are degreed doctors of naturopathic medicine. While they can’t perform major surgery or prescribe pharmaceuticals, they can do a lot for your health. Naturopaths rely on diet, exercise, and other non-invasive techniques to optimize … [Read more...] about Why You Might Want to Consider Naturopathy


The age of digital transformation produced by industrial enterprises shifting to new formsof production and actively using versatile information and communications technologies has madeissues with the management of digital potential especially vital. These trends have prompted theformation of integrated intellectual structures, called strategic innovatively active industrialclusters, whose primary unique feature is that they operate on a single digital platform. The purposeof this study is the construction of a structural-functional model for managing the digital potentialof a strategic innovatively active industrial cluster to use for creating a methodology to assess thispotential. The research methods include analysis and synthesis as well as graphic interpretationand content analysis. The main results of this study are as follows: a structural-functional model hasbeen developed for use in managing the digital potential of a strategic innovatively active industrialcluster that harmoniously reflects the roles of all the subsystems forming the cluster, and amethodology has also been developed based on the created model to help measure the digitalpotential of a cluster, using one such cluster in the city of St. Petersburg, Russia as an example. Thenovelty of this study is in its development of a model that fully and comprehensively reflects thespecial features of managing the digital potential of newly integrated structures such as strategicinnovatively active industrial clusters. In addition, the practical significance of the obtained resultsis that they can be used to calculate the real current values of the digital potential of these clustersand assist in the making of relevant management decisions for operational and strategic planning.


There are many causes for someone to cough, including the common cold, flu, or chest infection. Some essential oils may ease symptoms of cough or cold by soothing the throat, reducing inflammation, and clearing away mucus. Many essential oils can be used to relieve these symptoms. Eucalyptus essential oil This oil’s key compound is called…
Ravintsara Cinnamomum Camphora Ravintsara is a pale yellow or colourless essential oil, that originates from Madagascar. It is extracted from the dark green and waxy leaves of the large Cinnamomum Camphora tree in the Lauraceae family. Its name actually means "good leaf" in Madagascar. Ravintsara has a fresh smell that is similar to Eucalyptus or Camphor. Over…


While drivers who break traffic laws do not commit driver negligence, they may be cited for their role in a crash. Careless driving is one example of driver negligence, and it can lead to a collision. Common actions involving reckless driving include speeding, running stop signs, and illegal overtaking. These actions, and others, can place other drivers at risk. A citation can land you in jail for several months. If you were involved in a car accident because of a negligent driver, you should understand the dangers that such actions present.
Reckless driving
Reckless driving is the act of violating traffic laws by exceeding the posted speed limit or engaging in another unsafe driving behavior. Reckless drivers often violate traffic laws by speeding, failing to yield the right of way to pedestrians or vehicles, or driving while intoxicated. These dangerous driving behaviors are illegal and can result in traffic tickets, license suspensions, and even jail time. Here are some dangerous driving behaviors to avoid.
Reckless driving can be punishable by a fine of $100 to $300 and possibly jail time. The punishment for reckless driving will depend on the severity of the accident. If the driver has not given proper time to drive safely, it’s best to avoid dangerous behaviors such as speeding, swerving, running traffic lights, and changing lanes without signaling. Drivers should also refrain from being distracted while driving, as this can result in a crash and other dangerous behaviors.
Negligent driving
Driving with a lack of care is dangerous. Even minor violations can cause serious accidents and injuries. Drivers who are impaired may not be aware of the consequences of their actions and fail to react appropriately. In addition, drunk drivers can cause devastating accidents, even though they may be under the influence. However, it is important to note that it is not necessary to be legally drunk to be sued for negligence. While a drunk driver may be guilty of a violation, it is still important to show that they were directly responsible for the accident.
According to a highly experienced
truck driver negligence accident lawyer, the first driver negligence danger involves texting while driving. This is dangerous because it takes your hands off the wheel, distracts your attention, and can cause a collision. Fortunately, most states have laws that prohibit texting while driving. Another driver negligence danger is drinking hot coffee while driving. This can cause a car accident and burn the driver’s hands. Moreover, drinking coffee while driving can distract the driver and prevent them from paying attention to the road. Criminal negligence Driving recklessly and not paying attention to the road are dangerous and can lead to criminal negligence charges. A negligent person will act differently than the rest of the population. For example, it is dangerous to leave a loaded gun in the car with a small child. Driver negligence can even lead to involuntary manslaughter charges. This type of crime requires the plaintiff to prove that the other party was reckless or that the negligent driver failed to keep a safe distance from the child.
Driver negligence can come in many forms. It can include speeding more than the speed limit or operating a vehicle while intoxicated. There are other forms of driver negligence, including texting while driving and violating texting laws. These actions can result in accidents, including fatal crashes. Another type of driver negligence is intentionally leaving a child in the car. Despite its serious nature, driver negligence is extremely common in the United States, and many people have been charged with it.
Aggressive driving
The
driver’s negligence may have resulted in an accident, which may have led to injuries or even death. In some cases, the aggressive driving may have begun many years before the crash, and it may have even led to an accident before the driver was aware that their behavior was putting others at risk. If this behavior was not avoided, the driver may be held liable for criminal charges or civil liability. The injured party may also file a lawsuit against the aggressive driver, claiming that their negligent behavior caused the accident.
Drivers who are in a hurry are often more likely to engage in aggressive driving and road rage. They are often in a hurry to get somewhere, so they fail to factor in any potential delays. By giving yourself ample time to reach your destination, you will prevent some of the dangers of aggressive driving. By being cautious when approaching other vehicles and avoiding eye contact, you can help prevent a collision. Even though this may result in a traffic ticket, avoiding aggressive driving is still essential for your own safety.


A modern data strategy gives you a comprehensive plan to manage, access, analyze, and act on data. As a result, there is a shift to consider the adoption of a data mesh architecture where data is organized by domain, clear ownership of data and technology stack is enhanced, & a more agile setup is achieved. This would enable R&D teams in clinical & pre-clinical set-ups to further enhance discovery programs by achieving faster breakthroughs.
Sign up on our website and get the latest information in the field of bioinformatics.


PEAK PERFORMANCE
Peak performance, also known as flow, is a state of optimal functioning and is for individuals who are looking to improve their performance in mental, emotional, relational, occupational, social, and/or physical tasks. Improvement in these areas is achieved through a combination of biofeedback, neurofeedback, meditation, psychotherapy, and cognitive-behavioral therapy.
Fee: $200 per session


In a previous article, we noted that RFPs are expensive for both the vendor and the client. This heightens your team`s need to have a clear idea of what your firm is trying to accomplish by acquiring a new product or service. StartFragment Is the problem you`re trying to solve worth issuing an RFP? One way to approach better decision‐making is to review the different types of purchases where a competitive selection process is warranted. Replacement of an Existing Commodity Se


The Global Blockchain Business Council (GBBC) recently published its 2019 Annual Report, “Beyond the Hype: Building Blockchains for Real World.” The report provides a comprehensive update on the global regulatory landscape surrounding blockchain technology along with an overview of some of the blockchain solutions being built by GBBC members.
Steptoe authored an overall insights piece, titled “Regulation in the US: Where are We, and Where are We Going?,” which looks at where the United States stands in terms of regulation and predicts what we’ll see in terms of regulation in 2019. Steptoe also provided regulatory updates for the United States as part of a global regulatory overview, with specific insights on ICO regulation in the US.
To access the GBBC 2019 Annual Report click here.


Let’s take a quick quiz to help you gauge your capability. It’s a quick pen-and-paper exercise, and you’ll really get a lot out of it.
What are you capable of?
Answer Y=Yes or N=No to the following:
I prefer taking action rather than waiting for direction. I often prefer to express myself even if my perspective is different. I enjoy new and different challenges. I prefer doing similar things but in different ways. People describe me as confident and courageous. I prefer to share what I’m doing and support others whenever possible. I’m not put off by conflict, even if I don’t create it. I often seek higher personal goals. If I had a choice, I’d prefer doing what I like best regardless of where the experience takes me. I’m inclined to weigh all the options before diving in. I appreciate others and their contributions. I often feel like I’m holding myself back. I prefer to manage risk to avoid embarrassment. I can agree with the motto: “no pain, no gain.” I enjoy opportunities to test my talents and skills. I feel drained when I have to spend all my time figuring something out by myself. I like taking my experiences to a new level. I focus easily. I prefer structure in my free time. People tell me I’m a conscious listener.
How many statements did you mark Y for yes or N for no? Are you surprised at the results? There are no fixed scores.
Both being fearful or fearless falls along a continuum. Many people find themselves somewhere in between. The more you answered YES, the more likely you are to become more confident, more courageous and ultimately, more Fearless.
Whether you are just beginning your dream of becoming a leader or you already lead on some level, you can become even better.
Let me know – how did you do? Did you feel fearless or fearful? Why do you think you answered as you did?
Thanks for sharing.
For questions about this post or for information on becoming a fearless leader, contact Dr. Cathy Greenberg and The Fearless Leader Group at (888) 320-1299 or by email at hello@fearlessequalsfreedom.com.


A process that results in a new home. Architectural clients might experience confusion about this term because it represents several phases of the home design process. The process of residential design includes a contract that specifies details about design, construction and pricing obligations. Home owners who plan on interacting with an architectural firm can benefit from exploring residential design related concepts before the residential design meetings begin.
Once an owner outlines their needs, a residential design project launches. The creative activity behind meeting the desires of architectural clients is considered the first phase of residential design. The outcome of this effort is a home design plan, which will contain illustrations and informative details such as the required building materials, fixtures, appliances, hardware, doors and windows. This initial phase is refined until construction documents can evolve from the approved plan.
It is commonly understood that clients don't need to participate during the construction process. However, architectural clients can benefit from reviewing the final kitchen and bathroom layouts to inspect matters such as cabinet organization. A client might wish to increase participation during this stage of home design.
Talented architects offer clients the support they need during the construction of a new home. The residential design process may stretch beyond the scope of traditional architecture and into matters related to landscapes, interior design and pool or water features.
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The 101 on Fluoride
Fluoride is derived from the 13th most abundant element in nature, Fluorine. It naturally appears in the environment in the form of water and air. However, water is considered a vital dietary source of fluoride. In the 20th century, community water fluoridation was announced as one of the best public health achievements. Since this method was not feasible, especially in rural areas, experts like researchers and public policy makers started introducing fluoride to the general public through various methods. The various forms included adding fluoride to milk, toothpaste, and table salt.
Benefits of Fluoride
Although fluoride is typically added to foods and water, a dentist recommends that it be directly applied to the teeth through fluoridated mouth rinses and toothpaste. Mouth rinses generally contain fluoride in lower concentrations. However, more substantial concentrations need a dentist’s prescription. Fluoride supplements like tablets and liquids are available in markets and must be prescribed by a dentist or pediatric dentist.
The benefits of fluoride to teeth are mentioned below,
It protects teeth against decay which helps to strengthen the developing enamel. It slowdowns the loss of minerals and acid production of bacteria caused by plaque. It protects teeth against demineralization and promotes remineralization. It reverses early signs of tooth decay. It prevents cavities and the growth of harmful oral bacteria.
While fluoride is a naturally occurring compound, the intake of lower or higher fluoride concentrations can take a toll on your tooth health. The intake of lower fluoride concentrations leads to several health issues, including bone cancer, arthritis, and kidney-related diseases. The intake of higher fluoride concentrations leads to health issues, namely dental fluorosis and skeletal fluorosis, which occur when we consume too much fluoride. Dental fluorosis is generally observed in children under the age of eight as they tend to swallow toothpaste. It occurs when a child consumes excessive fluoride during the formation of teeth under the gums, resulting in white spots on the surface of the teeth. Skeletal fluorosis occurs due to long-term exposure to excessive fluoride, primarily through drinking water and sometimes swallowing toothpaste. Various reasons for higher fluoride in water sources include naturally large geologic deposits and accidental contamination from explosions or fires. Skeletal fluorosis involves weakening bones, including symptoms like stiffness and joint pains.
Dentists are worried about people opting for fluoride-free or natural toothpaste, as they don’t prove cavity prevention and only whiten the surface of teeth. Dentists will typically always recommend toothpaste that contains fluoride for oral hygiene. However, fluoride-free toothpaste can be recommended to people in very exemptional cases. For example, the person is allergenic to fluoride or due to swallowing habits (especially in children).
How to safely use fluoride
As per the data highlighted by the World Health Organization (WHO), it is found that around 2.4 billion people globally suffer from permanent dental caries, among which 486 million are children. As per studies, dental inequalities are evident when children (living in poorer countries) consuming non-fluoridated drinking water tend to get affected with tooth decay five times more than children consuming drinking water in fluoridated areas. When researching fluoride, it is best to discuss their views on fluoride in drinking water with your dentist or family physician.
When encouraging oral hygiene habits, it is recommended to supervise the children when they brush their teeth to ensure they won’t swallow toothpaste. Using concentrated fluoride oral health products must be under the supervision or advice of a dentist or pediatric dentist for young ones to use fluoride safely.
Before receiving a fluoride treatment, you must give the dentist or pediatric dentist details of your or the child’s health history. Fluoride treatment involves the direct application of highly concentrated foam, varnish, or gel through a brush, swab, mouthwash, or tray.
Before a dental cleaning or filling treatment, be sure to discuss any concerns related to fluoride and fluoride treatments.
As recommended by dentists, people need to use toothpaste that receives a seal of acceptance, like the ADA seal of acceptance in the United States. Children under the age of two are recommended to use not more than a grain-of-rice-sized amount of toothpaste.
To protect your enamel, please follow the recommended tips mentioned below:
Avoid eating drinks and acidic foods. Eat lots of veggies, fruits, and dairy products Don’t overbrush and avoid grinding your teeth Go for regular dental check-ups Avoid swimming in chlorinated pools
Have more questions on fluoride? Contact Ashraf Dentistry today!


Moments of sensory overload can be distressing for a child with autism as well as family members. It can often feel like the world is closing in, which can be extremely hard to communicate, primarily if the family member it affects the most struggles to express this feeling.
Our team at My World ABA understands this, and we want to support your family’s needs in these moments. This is why today’s blog will cover calming practices to engage your child during moments of sensory overload. We will be discussing two types of activities to engage in specifically to help prevent and move through sensory overload: organizing and calming activities.
Organizing Activities
Some individuals require physical activity to work through nervous energy. For children with autism, the understanding that they need to engage in an activity to help themselves might not be inherent to them. Some excellent practices to encourage would be to engage in the following exercises:
Resistance bands Running an obstacle course Stacking chairs Organizing crayons Sitting on a “move and sit” therapy ball
These activities allow them to focus the part of their mind that is seeking order or a puzzle-solving aspect to their daily routine, which can be calming during a moment of distress.
Calming Activities
For children who are already past the point of overstimulation, engaging in an activity that increases their blood pressure is not wise. Instead, the goal should be lowering their blood pressure and calming their breathing. Activities we recommend include:
Rocking slowly over a ball on their stomach Brushing over arms, backs, and legs Wrapping your child in a heavy blanket, body sock, or lycra material Allowing your child to create a dark, safe space by turning lights off in a room or making a tent
Moments that are perfect for children to engage in activities could include:
During a moment, your child is running around and becoming overstimulated Before/After an event that causes your child anxiety Before/After changes in routine Before/After school My World ABA On ABA Practices
Our team at My World ABA focuses on teaching each individual that passes through our doors what it means to be a kind, well-adjusted, and autonomous individual. We believe it is kind to teach people to function optimally within the beautiful boundaries of their world. Our goal is to help your family adjust in the way that works best for them. If your family needs additional support for calming practices, don’t hesitate to contact us online or call (417) 818-5784.


Detailed West Virginia Development
The West Virginia State Tax Department recently clarified that sales of streaming services are subject to the state’s sales and use tax. Under West Virginia law, all sales of services are subject to sales and use tax unless there is a specific exception or exemption. There is no exemption for streaming services. Streaming service providers, the guidance notes, are generally suppliers of entertainment or other content delivered electronically, usually by the internet, satellite, or cable connection to a subscriber’s device. The guidance then specifically differentiates between streaming services and sales of digital products, which are not subject to West Virginia sales and use tax. A digital product is a discrete identifiable item (e.g., the purchase or lease of a digital movie), whereas the purchase of streaming services provides a consumer purchasing access to curated entertainment content in the streaming service’s catalog, but has not procured a right to any specified digital product.
The West Virginia Department of Revenue has updated its SSUTA taxability matrix dated August 2, 2021 to reflect that while subscription services that provide digital content for permanent use (like a purchase) or less than permanent use (like a rental) are not subject to sales tax, streaming services are subject to the tax. Please contact Mark Balistrieri with questions on TSD-445 issued September 1, 2021.
This Week's Developments


The Minister of Communications, Dr. Isa Pantami, has reiterated the need for government officials to take the issue of E-Government from theoretical to a practical approach to ensure effective implementation E-Government, in line with the next level agenda of Mr. President.
Pantami stated this during a meeting with the Korea International Cooperation Agency (KOICA), led by it’s Country Director, Mr. Woochan Chang on Monday in Abuja.
The Minister said that the government officials must ensure that the country reaps the expected result for its socio-economic development by creating digital jobs.
“We must sit down and take the issue of E-Government from theoretical to practical approach. I am glad we already have the Master Plan in place.
“I always challenge my colleagues that, producing a master plan, blueprint or strategies is not enough until we do what we can to translate it into action.
“If a document is produced and documented in our place without implementation, the aim would have been defeated because the strategy is just theoretical.
“Execution of that theory is where our expertise needs to be displayed.
“We want to ensure that all the agencies in the ministry play significant roles in the area of E-Government implementation,” he said.
He commended KOICA for the support, collaboration and training it facilitated for many public servants in Nigeria.
Pantami expressed the commitment of the Federal government to continue partnering with KOICA, to move the E-Government implementation to the next level and thanked the organization for the provision of E-Government Training Centre at the Public Service Institute of Nigeria (PSIN).
He assured that government would ensure all that Ministries, Departments and Agencies partake in the training.
Earlier, Chang said that KOICA had been collaborating with the Ministry to develop E-Government in Nigeria for effective implementation of the E-Government in Nigeria.
Chang noted that the agency had engaged with other stakeholders such as the Open Government Partnership (OGP), Civil Society Organization (CSO) among others to achieve the aim.
He urged the ministry to come up with operational plans that would involve MDAs and state governments to ensure effective implementation of E-Government.


Car crashes do not always result in injuries, motorcycle accidents rarely do not. With few protections, motorcyclists involved in a crash are at high risk for injury. And many of them are quite serious. The Insurance Institute for Highway Safety (IIHS) reports that a death is 27 times more likely in a motorcycle crash.
As a motorcyclist in California, you must follow traffic laws, wear safety gear, and ride smartly. This will decrease your chances of being in an accident. Still, you may not escape a ride unscathed. Here are some of the more common motorcycle accident injuries we see:
Head Injuries
Head injuries are the most common injury type motorcyclists receive. A hit, puncture, or violent shake can be very serious. The injured rider is at risk for traumatic brain injury (TBI). This may be internal bleeding or a concussion. In this case, the rider needs emergency services ASAP for treatment. These injuries can have long-term consequences including permanent disability.
Head injuries are also a leading cause of motorcyclists’ deaths. The easiest way to reduce the risk of a fatal head injury is to wear a helmet. The U.S. Centers for Disease Control and Prevention report that helmets reduce the risk of death by 37 percent, and reduce the risk of head injury by 69 percent.
Thoracic Injuries
Thoracic injuries refer to injuries either in the thoracic spine (mid-region of the spine) or to the thoracic cavity, otherwise known as the chest cavity. These injuries may include:
Fractures to vertebrae within the thoracic spine; Fractures to ribs; Direct damage to lungs or airways; and Clavicle fractures.
These injuries can be very serious. They may lead to internal bleeding, a spinal cord injury, pain, and more. Also, a crash could lead to paralysis or death, too.
External Injuries and Injuries to Extremities
External injuries and injuries to extremities are also common. These types of injuries might include:
lacerations bruises road rash bone fractures amputation or crush injuries facial injuries
These injuries are very painful. They can be life-threatening, too. Severe bleeding or fracture leading to puncture of an internal organ could be fatal.
An experienced motorcycle accident lawyer can ensure you have the compensation needed to recover.


From zooming on smartphones and mid-air gestures to deformable user interfaces, thumb-index pinching grips are used in many interaction techniques. However, there is still a lack of systematic understanding of how the accuracy and efficiency of such grips are affected by various factors such as counterforce, grip span, and grip direction. Therefore, in this paper, we contribute an evaluation (N = 18) of thumb-index pinching performance in a visual targeting task using scales up to 75 items. As part of our findings, we conclude that the pinching interaction between the thumb and index finger is a promising modality also for one-dimensional input on higher scales. Furthermore, we discuss and outline implications for future user interfaces that benefit from pinching as an additional and complementary interaction modality.


1
Focus on emotional regulation:
The Skills System
Children and Adults who have experienced Adverse Childhood Experiences tend to have significant difficulties managing emotions, which impacts their abilities to effectively form and maintain relationships, display pro-social behaviors, and often results in impulsive behaviors placing them at risk of further adverse experiences. The Skills System® created by Dr. Julie Brown is a Dialectical Behavior Therapy-informed emotion regulation skills training curriculum consisting of nine core skills and three System Tools that help people be effective at all levels of emotion. The Skills System is taught in the context of group therapy (or individual if needed) and is inclusive of the primary caretaker, such as a parent or DSP. The primary caretaker is also provided with an opportunity to participate in weekly consultation with the LifeConnect Health team to receive support in being effective in helping the individuals to practice and master the skills in their daily environment.
2
Who can benefit?
LifeConnect Health's goal is to provide necessary, appropriate, and accessible services to those who are either underserved or in need of innovative interventions. Therefore, our focus has been to support:
- Adults and Children with I/DD who experience behavioral challenges and for whom traditional interventions have not been effective.
- Children, adolescents and transitional age youth who have experienced adverse childhood experiences.
- Children and Adults who are Deaf or Hard of Hearing, specifically those who have been exposed to language deprivation or have experienced trauma driven by the absence of linguistically competent supports.
3
What to expect from the service
Our service is defined by the integration of evidenced-based and theoretical models, including:
- Julie Brown’s Emotion Regulation Skills System®,
- Biopsychosocial approach,
- Systems of Care model,
- Person First approach, Trauma Informed, and Positive Psychology,
- Peer Support recovery-oriented approach
- Neuropsychiatric cognitive capacity measures
Each individual served receives a comprehensive assessment to help define an individualized appropriate treatment plan. We recognize individuals referred may have diverse needs therefore we offer an array of services to create a comprehensive treatment delivery.
Services offered include:
- Emotional Regulation Skills training group
- Daily Morning Meetup group therapy
- Peer Support Services
- Psychiatric Advocacy, including pharmacology review and coordination of physical and behavioral health.
- Collaboration of care with existing caretakers and treatment teams.
- Administration of specialized testing when needed, such as evidenced-based service intensity scales and cognitive assessment.
- Although group therapy is the main treatment modality, trauma-focused team based individual therapy is provided when necessary.
4
Why Telehealth?
Telehealth offers significant benefits in our model and has proven to be a very successful delivery model:
1- Telehealth allows us to bring practitioners from multiple states who have unique expertise in supporting our members, including psychiatrists and therapists who are Deaf and able to deliver the services in ASL.
2- Telehealth removes the transportation barriers for our members, their families, or residential providers.
3- Telehealth also promotes self-direction and accountability as the member has ownership over his/her level of participation in his/her own treatment.
4- Most importantly, as we work with individuals who experience frequent placement disruptions, it allows for the relationships that they have formed with our providers and their peers to move with them, reducing the experience of relationship loss they are so frequently affected by.
5- With the portability of the services provided goes along the treatment history and critical information which can be communicated effectively to new treatment settings, minimizing the risk of repeating unsuccessful interventions.


Executive Summary
Recent inflation headlines have many investors on edge. As investors, we constantly challenge our own thinking and question when a transitory inflationary period may evolve into something different. In this instance, however, we believe high inflation is a confirmation of an accelerating expansion phase in the business cycle and investors should remain constructive on the market outlook. Our outlook is predicated on two primary objectives: containing COVID-19 and a reacceleration of global earnings revisions. Third-quarter earnings season is underway, and revisions thus far remain positive. We believe inflation pressure from supply chain bottlenecks stem from labor shortages due to the pandemic. PNC Economics expects to see further progress in the labor market in the coming months, which should continue to alleviate near-term supply chain shortages. We continue to keep a close eye on market indicators but believe markets are priced for a long-term recovery from last year’s recession.
Highlights The Consumer Price Index (CPI) has remained above 5% for the longest period since the early 1990s. When compared to the accelerating expansion phase we experienced after the 2009 recession ended, recent CPI data shows a nearly identical trough-to-peak spread. Over the past year, there have been three distinct waves of global COVID-19 cases that overlap with notable movements in commodity prices such as lumber and semiconductors. While the first CPI report above 5% was on June 10, from June 10 through October 15, equity markets were driven by large-cap and growth stocks — not at all what a sustained high inflation backdrop would suggest. Markets can adapt to new information quickly and look beyond the short term.


Liquidity Pools and Liquidity Mining Explained
Besides yield farming, liquidity mining has become one of the hottest DeFi trends. Liquidity pools enable investors to earn interest via liquidity mining. But how do these liquidity pools work, and what are they?
Currently, Uniswap is still the leader in terms of total value locked (TVL) in their liquidity pools, with a locked value of $1.38 billion. Sushiswap closely follows Uniswap with a $1.03 billion TVL.
This article explores how liquidity pools work, rebalancing, automated market makers, how they prevent slippage, and the investors' incentive to add liquidity? An Introduction to Liquidity Pools
To better understand the need for liquidity pools, let’s first examine what problems they solve. Traditional peer-to-peer decentralized exchanges often lack liquidity. This lack of liquidity is a significant user experience (UX) problem for its users as they frequently experience slippage.
“Slippage refers to the difference between the expected price of a trade and the price at which the trade is executed.” - Investopedia
To illustrate this with an example, imagine you place an order for a particular cryptocurrency at the price of $9.50. However, due to a lack of volatility, your order closes at the price of $9.60 or even higher.
In other words, you’ve just paid more money than you expect to pay for your order. Slippage can be dangerous for trading bots that rely on predictable pricing. Even a small percentage of slippage can turn a profitable trade into an unprofitable trade like arbitrage trading.
This problem led to the introduction of liquidity pools.
Liquidity Pools and Pool Rebalancing
Liquidity pools guarantee liquidity at every price level. A liquidity pool always consists of two cryptocurrencies. When participating in a liquidity pool, we’ve to add equal value for both currencies. On top of that, we want to maintain a fixed 50/50 ratio for the value in both pools. If that value deviates, we have to rebalance the pool.
Imagine we’ve created a fictive liquidity pool that allows traders to swap lemons and strawberries. We have to set a constant value that determines the balance between both
currencies. For example, each lemon is worth five strawberries.
Now, Carly wants to sell one lemon in return for five strawberries. Therefore, this swap adds one lemon to the lemons pool and removes five strawberries from the corresponding pool. However, this means that there’s no 50/50 ratio anymore.
In this case, we have to rebalance the pool. We can rebalance the pool by adjusting the price between lemons and strawberries. As there are fewer strawberries, the price for strawberries increases. In contrast, there are more lemons. Therefore, the price for lemons decreases.
All these actions are controlled by an automated smart contract that holds both balances and automatically adjusts prices. People often refer to this mechanism as automated market makers (AMM).
How Does Rebalancing Guarantee Liquidity?
Rebalancing is essential to guarantee liquidity at each pricing level. You might wonder why, as the pool will eventually run out of lemons or strawberries.
Yes, you are right about that. However, we also have to consider economic rules.
Every time a user swaps lemons for strawberries, the price for strawberries will increase. As this is a y = k/x graph (hyperbola graph), the price increases rapidly the more people swap lemons for strawberries.
At some point, users will spot this opportunity and will start swapping strawberries for lemons as they have become incredibly cheap. This event is known as market efficiency or market balancing. Often, arbitrage bots are good at maintaining a healthy balance for open markets.
How Does a Liquidity Pool Prevent Slippage?
To understand how liquidity pools prevent slippage, we must understand the difference between traditional P2P exchanges and liquidity pool exchanges (or swap exchanges).
A traditional P2P exchange maintains an order book where traders can add orders. Often, there aren’t plenty of orders for more exotic trading pairs, making it hard to use these exchanges.
However, liquidity exchanges don’t rely on an order book to enable trading. Investors add funds to these pools to guarantee liquidity. By automatically adjusting the price, there’s always liquidity at each price level.
It is great because we can create any new trading pair and add immediate liquidity as long as plenty of people add funds to the pool.
For example, you want to swap USDT for USDC. However, no centralized exchange offers this trading pair, you don’t want to make additional trading steps to end up with USDC, and there’s not sufficient liquidity on a P2P exchange to fulfill your large order.
We can quickly create a new USDT/USDC trading pool and wait for people to add tokens to the pool. Now, you can easily swap your USDT for USDC. It’s an excellent alternative for traders who want to enjoy a great user experience while staying within the decentralized space.
Why Would Investors Add Funds to Liquidity Pools?
Here comes the juicy part: gain more profits! For each swap, a trader pays a small fee. For example, Uniswap charges a 0.3% fee. This fee gets added to the pool.
Imagine the same USDT/USDC pool. As both coins are stablecoins worth one dollar, we have to add equal amounts of both tokens. Therefore, we decide to add $100 of USDT and $100 of USDC.
Every time a trader swaps tokens in any direction, the fee gets added to the pool. As a liquidity provider, we can claim a proportional stake of this pool’s fees based on our stake in the pool.
For example, our $200 investment represents 0.8% of the pool’s balance. Therefore, we can claim 0.8% of the accrued fees when withdrawing our investment from the pool.
Aren’t You Losing Money as an Investor by Adding Money to Liquidity Pools?
No, this is not true. We’ve mentioned the 50/50 ratio we want to maintain for each pool. Our underlying smart contract (automated market maker) takes care of managing this ratio.
Your funds' distribution will indeed shift. In our lemons and strawberries example, Carly sells one lemon for five strawberries. Imagine the pool consisted of 100 lemons and 500 strawberries. Now, the balance has shifted towards 101 lemons and 495 strawberries. The smart contract will adjust the price, so the value of each pool is equal.
As you can see, your investment will shift over time between both
currencies, but the invested value remains the same due to the 50/50 ratio. Conclusion: Why Use a Liquidity Pool Exchange?
To conclude this article, let’s take a look at the arguments for using a liquidity pool exchange. Here they are.
Guaranteed liquidity at every price level No need to use centralized exchanges or decentralized exchanges with high slippage Often offers low trading fees Freedom to create new liquidity pools Allows for new projects to gain immediate liquidity without the need for an ICO
If you consider investing in liquidity pools, stick to well-established liquidity pools. We’ve seen several rug pulls for scam tokens being listed as new liquidity pools where the token creators remove their liquidity after attracting some initial liquidity.


In law, fraud is intentional deception to secure unfair or unlawful gain, or to deprive a victim of a legal right. Fraud can violate civil law (e.g., a fraud victim may sue the fraud perpetrator to avoid the fraud or recover monetary compensation) or criminal law (e.g., a fraud perpetrator may be prosecuted and imprisoned by governmental authorities), or it may cause no loss of money, property, or legal right but still be an element of another civil or criminal wrong. The purpose of fraud may be monetary gain or other benefits, for example by obtaining a passport, travel document, or driver’s license, or mortgage fraud, where the perpetrator may attempt to qualify for a mortgage by way of false statements.A hoax is a distinct concept that involves deliberate deception without the intention of gain or of materially damaging or depriving a victim. https://en.wikipedia.org/wiki/Fraud


The gastrointestinal tract in the adult Drosophila serves as a model system for exploring the mechanisms underlying digestion, absorption and excretion, stem cell plasticity, and inter-organ communication, particularly through the gut–brain axis. It is also useful for studying the cellular and adaptive responses to dietary changes, alterations in microbiota and immunity, and systematic and endocrine signals. Despite the various cell types and distinct regions in the gastrointestinal tract, few tools are available to target and manipulate the activity of each cell type and region, and their gene expression. Here, we report 353 GAL4 lines and several split-GAL4 lines that are expressed in enteric neurons (ENs), progenitors (ISCs and EBs), enterocytes (ECs), enteroendocrine cells (EEs), or/and other cell types that are yet to be identified in distinct regions of the gut. We had initially collected approximately 600 GAL4 lines that may be expressed in the gut based on RNA sequencing data, and then crossed them to UAS-GFP to perform immunohistochemistry to identify those that are expressed selectively in the gut. The cell types and regional expression patterns that are associated with the entire set of GAL4 drivers and split-GAL4 combinations are annotated online at /index.php (K-Gut Project). This GAL4 resource can be used to target specific populations of distinct cell types in the fly gut, and therefore, should permit a more precise investigation of gut cells that regulate important biological
processes.


Studies have shown that seniors who regularly read have better decision-making ability, reduced stress, and improved memory. Reading can also reduce anxiety, allow you to sleep better, and delay the onset of Alzheimer’s disease and dementia.
Below is a list of 5 must-read books for seniors along with a short summary of each book. 1. The Nightingale by Kristin Hannah.
This novel celebrates the durability of women and the resilience of the human spirit. The Nightingale takes place during World War II, telling the story of the struggle of two sisters, Vianne and Isabelle, to survive. Each sister embarks on a dangerous path toward freedom, survival, and love.
2. A Man Called Ove by Fredrick Backman.
In this book, the neighbours of a sad and lonely old man call him the bitter neighbour from hell because of his grumpy nature. However, this changes when new, young neighbours move next door to him. This novel explores the power of intergenerational friendship. If you enjoy reading the book, there is a movie, which is also called A Man Called Ove, based on the book.
3. I Am Malala: The Girl Who Stood Up for Education and Was Shot by the Taliban by Malala Yousafzai.
This novel is an autobiography following Malala’s activism for female education that resulted in an attempted assassination against Malala. This novel earned Malala the Nobel Peace Prize in 2014.
4. When Breath Becomes Air by Paul Kalanithi.
This is a non-fiction autobiographical book about Paul Kalanithi’s life from a neurosurgeon treating patients to a patient being treated and struggling to live.
5. The Handmaid’s Tale by Margaret Atwood.
In this novel, the United States government is overthrown by a totalitarian state. It explores many themes including the role of childbearing in society, the role of religion in society, and women’s rights.
This article is not intended to be a substitute for professional medical advice or diagnosis. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.


Abstract
The X11/MINT family proteins are adaptor scaffolding proteins involved in formation of multiprotein complexes, and trafficking and metabolism of membrane proteins such as the beta-amyloid precursor protein. We found that a significant portion of X11L and X11L2 are recovered in nuclear fraction of mouse brain homogenates. EGFP-X11s were not detected in the nucleus of N2a neuroblastoma cells; however, administration of leptomycin B (LMB) induced substantial nuclear accumulation of EGFP-X11L and EGFP-X11L2, while EGFP-X11 showed little accumulation. Fluorescence loss in photobleaching (FLIP) analysis indicated that EGFP-X11L2 and EGFP-X11L are shuttled between the cytoplasm and nucleus, the former more effectively than the latter. We identified a nuclear export signal (NES) in the N-terminus of X11L2, mutation of which induces nuclear accumulation of EGFP-X11L2 in the absence of LMB. X11L2 fused to the Gal4 DNA binding domain (DBD) showed transcriptional activity, suggesting that X11L2 could function as a transcriptional activator if tethered near a promoter. Interestingly, attenuation of the nucleo-cytoplasmic shuttling of GAL4-DBD-X11L2 by mutating the NES or attaching the SV40 nuclear localization signal significantly decreased the apparent transcriptional activity. Our observations suggest that X11L2 functions in the nucleus by a mechanism distinct from conventional transactivators.
Keywords MINT1 MINT2 MINT3 Nuclear export Nuclear localization Nucleo-cytoplasmic shuttling X11 X11L X11L2 ASJC Scopus subject areas Cell Biology


Students are restrained across Texas on a daily basis, but many schools underreport or fail to report incidents altogether. A child may be restrained twelve times in a school day, but in official records, it may only say once or zero. Both state and federal reports have listed major Texas school districts as potentially underreporting due to anomalous data.
Restraint results in both short and long-term consequences, hampering a child’s ability to develop socially, emotionally, and academically. Accurate data is necessary to ensure that comprehensive legislation regarding restraint can be introduced and existing policies can be evaluated.


Asset Publisher
Energy major ONGC has been recognized as the ‘Maharatna of the Year (Non-Manufacturing)’ among India’s Best Public Sector Undertakings 2020 by the Dalal Street Investment Journal. This recognition is a testament to ONGC’s sustained contribution to nation-building, ensuring energy security and supporting the country’s economic growth. It holds special significance in the face of the hardship brought by the ongoing COVID-19 pandemic.
Strong operational and financial performance in the strategically important sectors of oil and gas has put ONGC among the top performing PSEs. The acknowledgement of ONGC’s contribution by DSIJ, one of the country’s leading voices in trade and investment, delivers a much-needed boost to the morale of the energy soldiers of the country.
The recognition was awarded to ONGC after an in-debt assessment of the stature, finances, performance, operational efficiency and growth of the company relative to its peers in the category by a panel of eminent jurists of DSIJ. The basic parameters to assess the winner companies are in terms of balance sheet, size, net sales and profitability. The awards will be published as a Collector’s Edition with the Dalal Street Journal May 2021 edition.
The journal has been recognizing the efforts and brilliant achievements of the PSUs in India since 2009 with this flagship initiative. Over the years, it has served as an exclusive platform to recognize the accomplishments of PSUs in India. Notably, ONGC has featured in the list of Best Public Sector Undertakings numerous times in one or another category.
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Abstract
There is growing evidence that populations of the northern flying squirrel (Glaucomys sobrinus) are declining in the eastern United States, perhaps due to competition with the southern flying squirrel (Glaucomys volans). Potential causes include parasite-mediated or apparent competition from the shared intestinal nematode, Strongyloides robustus, which has been shown to detrimentally affect the northern flying squirrel but not the southern flying squirrel. To investigate this hypothesis, we conducted a preliminary study on the parasite community of both flying squirrel species from sites in Pennsylvania where the two species occur sympatrically and where G. sabrinus is now considered endangered at the state level. We compared these parasite communities with those from northern flying squirrels from northern New York where the southern flying squirrel is absent. We found eight species of gastrointestinal parasites (Pterygodermatites peromysci, Lemuricola sciuri, Syphacia thompsoni, Syphacia spp., Capillaria spp., Citellinema bifurcatum, Stwgyloitdes robustus, and an unidentifiable cestode species) in both species of flying squirrels examined for our study. The parasite-mediated competition hypothesis was partially supported. For example, in Pennsylvania, S. robustus was overdispersed in southern flying squirrels, such that a small proportion of the hosts carried a large proportion of the worm population. In addition, we found S. robustus to be present in northern flying squirrels when the species were sympatric, but not where southern flying squirrels were absent in New York. However, there was no association between S. robustus and the body condition of flying squirrels. We detected a potential parasite community interaction, as S. robustus abundance was positively associated with P. peromysci.
All Science Journal Classification (ASJC) codes Ecology, Evolution, Behavior and Systematics Ecology


In the CASEL framework, authentic partnership with families and caregivers is one of four key settings for SEL efforts. In an authentic partnership, partners work together to define challenges, develop shared goals, and design plans to promote SEL. This requires intentional relationship-building and genuine appreciation for the perspectives and skills that families bring (from this point forward, the word “families” is used to refer inclusively to the variety of attached relationships between students and the adults who care for them in homes and residences). When schools and families work together, they can build strong connections to ensure that SEL is taught in culturally responsive ways that celebrate the assets, identities, and diversity students bring to school, making SEL more impactful and lasting.
School personnel must reflect on the power dynamics between schools and families that may hinder authentic partnership, then work to recalibrate relationships. It is common for family engagement strategies to be enacted with a deficit lens, especially in communities where many families experience marginalization based on race, class, language, or immigration status (Mapp & Bergman, 2021). Recalibration requires that school staff position all families as experts about their own children, whose experience and knowledge make them essential partners for shaping students’ school experiences. Schools build trust with families when they are aware of and responsive to community needs, cultural practices, and history, and when they center the voices of students, families, and the community as they set goals and make decisions.
Research suggests that evidence-based SEL programs are more effective when they include strategies for connecting with students’ families (Albright & Weissberg, 2010). Families can provide educators with key insights about their children, their community, and their values. Schools can build upon and learn from these funds of knowledge and the strategies that families are already using to support SEL (Mapp et al., 2013).
Families are far more likely to join partnership efforts when the school’s norms, values, and cultural representations reflect their own experiences (Atunez, 2000). A sense of school connectedness is stronger when students feel that they, their family, their culture, and the people and contexts with which they feel most at home are respected and included in their schools. For these reasons, it is important for teams to foster a culturally responsive and welcoming school environment as they authentically engage families as partners in promoting students’ SEL.
If you have already begun develop family partnerships for SEL, use the rubric or the questions below to identify areas for continuous improvement:


Given the size of the vehicles they command, truck drivers must take their jobs seriously and remain focused on the road ahead of them when they are behind the wheel. Unfortunately, even a single reckless act or moment of carelessness by a commercial truck operator can have serious consequences for anyone involved in an ensuing crash.
If you sustained injuries because of a truck driver or trucking company’s negligence, you have a limited amount of time to retain a skilled attorney and seek the compensation you deserve for your damages. By speaking with a Braselton truck accident lawyer sooner rather than later, you could more effectively enforce your legal rights and pursue a positive case resolution.
Everyone in control of a moving motor vehicle—especially those operating commercial trucks that weigh tens of thousands of pounds—have an implicit obligation to obey the law, watch out for surrounding cars, and generally act in a reasonable way. A violation of this “duty of care” forms the foundation of a personal injury lawsuit. If an injured plaintiff can prove a defendant’s breach of duty directly caused their injuries, they could hold that defendant liable for all damages those injuries cause.
Just like commuter car operators, truck drivers can bear liability for reckless or careless actions that proximately cause crashes, like merging without signaling, exceeding the speed light, or not checking blind spots before turning. However, trucking companies may also bear fault for these kinds of incidents, either by assuming vicarious liability for their employee’s irresponsibility, or because they were reckless themselves in some way.
In other cases, third parties not directly involved in a truck crash may still be to blame for that incident occurring. For instance, a mechanic may have failed to repair a defective truck component, or a supplier may have overloaded a truck with cargo or failed to secure cargo before transit. A Braselton truck accident attorney could provide crucial assistance identifying the right party or parties to incorporate into a claim as defendant(s).
A truck crash victim who successfully proves another party at fault for their injuries may seek restitution for every direct consequence of the physical harm they sustained. Importantly, recoverable damages may be economic or non-economic, and they may include both losses the plaintiff has already experienced at the time of filing and losses they will likely experience in the long term because of their injuries.
Specific damages that a local truck crash lawyer could potentially pursue restitution for on a plaintiff’s behalf include:
Truck drivers and trucking companies each have an important obligation to act carefully and safely so they can minimize the risk of life-altering traffic accidents. When an accident occurs because of someone acting negligently, civil litigation may be the best means for impacted parties to achieve financial stability and protect their future prospects afterwards.
A qualified Braselton truck accident lawyer could be the ally you need to effectively pursue the restitution you deserve. Call Smith Hulsey today to learn more.
Smith Hulsey Law


Immune checkpoint inhibitors and MDSCs Immune checkpoint inhibitors and MDSCsThe development of immune checkpoint inhibitors (ICIs) targeting lymphoid cells has remarkedly transformed therapeutic approaches for the treatment of cancer. However, response rates to T cell checkpoint inhibitors vary between individuals with some patients showing minimal to no clinical benefit. In these patients, resistance to this immunotherapy may be partly attributed to myeloid- derived suppressor cells (MDSCs), a heterogeneous population of myeloid progenitors and immature myeloid cells that function as immune suppressors. July 16, 2020


Horror is a genre of literature, film, and television that is meant to scare, startle, shock, and even repulse audiences. The key focus of a horror novel, horror film, or horror TV show is to elicit a sense of dread in the reader through frightening images, themes, and situations. In the horror genre, story and characters are just as important as mood and atmosphere. A horror story often shocks and provokes with its exploration of the unknown.
The horror genre in literature dates back to Ancient Greece and Ancient Rome, where horror stories explored themes related to death, demons, evil spirits, and the afterlife. Examples include the ancient Greek tragedy Hippolytus by Euripides, a gruesome story about how jealousy and a lack of empathy can lead to tragedy; and Parallel Lives by Plutarch, a series of biographies highlighting the many moral failures of man.
The gothic novel, a genre of horror that focuses specifically on death, originated in the eighteenth century and is exemplified by the author Edgar Allan Poe. Horror literature in the nineteenth century and twentieth centuries often focused on tales involving occult ideas, like Mary Shelly’s Frankenstein (1818) or Bram Stoker’s Dracula (1897).
Modern horror novels have expanded the genre to include new elements and contemporary themes, like serial killers and slasher stories—Stephen King’s The Shining (1977) is a perfect example—as well as genre mashups that combine horror with historical fantasy, and modern interpretations of fantastical creatures, like ghosts, vampires, werewolves, and witches.
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Today, Prime Minister Justin Trudeau was joined by ministers and senior officials for a second meeting of the Incident Response Group to discuss the impacts of Hurricane Fiona, which is affecting hundreds of thousands of people across Atlantic Canada and Eastern Quebec.
During the meeting, the group expressed concern over the devastating impacts of the hurricane. Despite efforts over the last 24 hours, thousands of Canadians remain without power, and many people in the most affected regions have lost homes and have been displaced due to flooding, extremely high winds, and storm surges. They also spoke of the hurricane’s significant impact on the local fishing industry.
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The federal government and the @CanadianForces will do whatever it takes to help Canadians deal with the impacts of Hurricane Fiona. Here’s an update on what we’re doing to keep Canadians safe: pic.twitter.com/L06W5fsEri
— Anita Anand (@AnitaAnandMP) September 25, 2022
Officials briefed the group on the trajectory of the storm, which continues to weaken as it moves northward, noting that improving conditions should facilitate work to assess damage and initiate cleanup efforts. The Prime Minister and ministers acknowledged the modelling work of the Canadian Hurricane Centre, which helped provincial and municipal officials and Canadians prepare for and mitigate potential impacts of the storm.
Ministers and senior officials provided an update on ongoing efforts across the federal government to engage with provincial counterparts, municipal partners, and local First Nations communities to provide support in areas affected by the hurricane. They also recognized the tireless work of first responders and emergency relief organizations, including the Canadian Red Cross, in providing support to impacted communities.
The group was briefed on the work of Canadian Armed Forces (CAF) members, who have been deployed in Nova Scotia in response to a request by the province, to help assess the hurricane’s impacts, remove debris, and restore transportation routes. Officials also noted that Transport Canada’s National Aerial Surveillance Program is currently conducting reconnaissance over affected areas and providing data to support restoration efforts. The group noted the approval of Prince Edward Island’s request for assistance and potential requirements for assistance in Newfoundland and Labrador – a request from Newfoundland and Labrador has since been received and approved. CAF members and other federal personnel and equipment, including the Canadian Coast Guard, Royal Canadian Navy, and Royal Canadian Air Force, have been mobilized and are ready to help in affected areas.
The Prime Minister and ministers discussed the severe damage from the hurricane to power and telecommunications infrastructure, and the ongoing work within provinces to restore these services. Ministers and officials continue to engage with their provincial counterparts and with industry and utility representatives to ensure that all necessary support is available and that services can be restored as quickly as possible.
Recognizing the longer-term economic impact of the storm, the group spoke of the federal financial assistance available to impacted provinces through the Disaster Financial Assistance Arrangements to help with response and recovery costs. The group also discussed how the Canadian Red Cross and matching federal funds will be available to address more immediate requirements for support for affected Canadians and their families.
The Prime Minister reiterated that the federal government stands ready to provide support to impacted provinces during this difficult time. He asked ministers and senior officials to continue working closely with provincial and local governments, affected First Nations communities, and emergency response organizations to respond to the needs of impacted people and communities. The Prime Minister urged Canadians to stay safe by following the advice from their local authorities and committed to visiting impacted areas as soon as it is possible and responsible to do so.
SOURCE PMO


As schools begin this fall, educators across Ohio are rightly concerned about student attendance and engagement. From 2020-2021 to 2021-2022, the statewide rate of students missing at least 10% of their instructional time due to absences increased by six percentage points to 30.2%. Chronic absenteeism has risen across nearly all grade levels, district types and student subgroups
To address these concerns, the Ohio Department of Education has developed a new resource. Keeping Ohio Students Present, Engaged and Supported offers multitiered interventions that schools and districts can implement to address and prevent chronic absenteeism. The guidance addresses four key areas: taking a team approach, positive conditions for learning, using a multitiered approach and working with partners.
For more information about supporting student attendance, visit the Department’s Attendance Support webpage.
Please direct questions to the Office of Whole Child Supports at attendance@education.ohio.gov or (614) 387-2202.


Editorials Atopic dermatitis (AD) is a very common skin disease associated with substantial burdens on patient health and quality of life. Knowledge regarding the pathogenesis of AD has expanded within recent years, leading to novel and efficacious therapeutic agents. Similarly, our knowledge of the impact of AD on patient's mental and physical health has also expanded. This review summarizes updates on the evolution, comorbidities, and therapeutic options of AD. AD is associated with increased cardiovascular risk, allergic diseases, and adverse mental health outcomes. T2-low asthma is an often severe asthma subtype with limited treatment options and biologic therapeutics are lacking. Several monoclonal antibodies (mAbs) targeting non-T2 cytokines were previously reported to be ineffective in asthma. These trials often investigated heterogeneous asthma populations and negative outcomes could be related to unsuitable study cohorts. More tailored approaches in selecting participants based on specific biomarkers have been beneficial in treating severe T2-high asthma. Severe asthma is associated with substantial personal and economic burden; maintaining disease control is the key management goal. Increased understanding of asthma heterogeneity and development of type 2 (T2)-targeting biologics has substantially advanced disease management and outcomes; however, despite both being driven by T2 inflammation, allergic and eosinophilic asthma have different treatment recommendations. We sought to better understand the similarities and differences between allergic and eosinophilic asthma and highlight where misconceptions may arise. Treatment for chronic rhinosinusitis with nasal polyps (CRSwNP) generally involves intranasal corticosteroids (INCS) and saline irrigation, followed by short courses of systemic corticosteroids (SCS) or surgery with postoperative medical therapy for patients who do not respond to INCS. However, both SCS use and surgery are associated with a range of adverse effects or complications, have a high recurrence rate, and are unsuitable for some patients. Biologics targeting the underlying pathophysiology are promising treatment alternatives for these patients.


The Russell 2000 index, which gauges the performance of small-capitalization stocks, ended Thursday down more than 20% from its recent high, meeting the commonly used definition of a bear market.
The index
RUT, which closed at a record of 2,442.742 on Nov. 8, finished about 21% from its peak on Thursday, marking its first bear market since March 9, 2020. The index needed to avoid a close at or below 1,954.19 to avert a bear market, but selling pressure forced the index deep into the red.
The index led the way in the past stock-market downturn in 2020 as the COVID pandemic took hold in the U.S. The benchmark is often viewed as an area of the market that tends to be more sensitive to concerns about economic growth, rising inflation and rising interest rates, all conditions that the economy is experiencing or will likely experience in coming months as the U.S. Federal Reserve sets the stage for a series of rate increases starting in March.
After the Russell 2000 index entered a bear market in early March, the Dow Jones Industrial Average
DJIA, closed in bear market on March 11. The S&P 500 SPX, and Nasdaq Composite COMP, entered bear markets a day later.
Flash forward to 2022 and the Nasdaq Composite is already in correction, defined as a decline of at least 10% (but not more than 20%) from its Nov. 19 peak. The index is about 17% from its November peak and the S&P 500 stands about 10 points from a correction, as of Thursday’s close.


October 15 th Australian immunologist and pathologist who, with Swiss-born Rolf Zinkernagel, shared the Nobel Prize for Physiology or Medicine in 1996 for their project at the John Curtin School of Medical Research in Canberra, Australia (1973-5). Using mice, they studied how the immune system’s T-lymphocytes, recognize virus-infected cells from healthy cells. The “killer T-cells,” in a test tube killed cells infected by a virus, and worked only against a specific virus in a specific mouse and could not be transferred to a different animal.


Protecting The Springs
The pump yard’s large tank stores chlorinated drinking water. In the past, rare overflow events discharged water from the tank into the springs, potentially harming the invertebrates living in this sensitive ecosystem. As part of the site’s restoration, we added overflow sensors to the tank and modified its overflow pipe to prevent chlorinated water from entering the springs in the unlikely event of a future overflow.
If an overflow does occur, the elevated pipe will divert the chlorinated water away from the springs and into the splash basin on the nearby hilltop. This allows natural drainage and filtration to neutralize the chlorine in the water before it reaches sensitive waterways.
Uncapping the Springs
A key element of our environmental restoration effort was the removal of a portion of the 1930s-era concrete cap that covered the site’s headwater spring. With the spring cap now open, organic matter falls into the water, living plants thrive, and beneficial microorganisms proliferate. This adds nutrients critical to the health of the spring’s fragile ecosystem, which is home to several rare and endangered species.