Here, we report the complete genome sequence and full methylome analysis of a newly isolated, aerobic, thermophilic, Gram-positive actinomycete, a strain of Thermoactinomyces vulgaris designated strain 2H.Copyright © 2019 Mankai et al.
Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of methylated residues in bacterial genomes has prevented a full understanding of their functions. Now, advances in DNA sequencing technology, including single-molecule, real-time sequencing and nanopore-based sequencing, have provided new opportunities for systematic detection of all three forms of methylated DNA at a genome-wide scale and offer unprecedented opportunities for achieving a more complete understanding of bacterial epigenomes. Indeed, as the number of mapped bacterial methylomes approaches 2,000, increasing evidence supports roles for methylation in regulation of gene expression,…
The Geobacter species evolved respiratory versatility to utilize a wide range of terminal electron acceptors. To explore this adaptive mechanism, Fe(III) citrate, hydrous ferric oxide, and fumarate were selected as electron acceptors, and the methylome and metabolome of Geobacter sulfurreducens PCA grown on each electron acceptor were investigated via third-generation, single-molecule real-time DNA sequencing and gas chromatography/time-of-flight mass spectrometry-based metabolomics, respectively. Results showed that the patterns of 4-methylcytosine (m4C) and 6-methyladenine (m6A) modification, the concentrations of fatty acids (e.g., caprylic acid, capric acid, and squalene), and the activity of antioxidant enzymes (e.g., superoxide dismutase, catalase, and glutathione reductase) were all…
Pseudorabies virus (PRV) is the causative agent of Aujeszky’s disease giving rise to significant economic losses worldwide. Many countries have implemented national programs for the eradication of this virus. In this study, long-read sequencing was used to determine the nucleotide sequence of the genome of a novel PRV strain (PRV-MdBio) isolated in Serbia.In this study, a novel PRV strain was isolated and characterized. PRV-MdBio was found to exhibit similar growth properties to those of another wild-type PRV, the strain Kaplan. Single-molecule real-time (SMRT) sequencing has revealed that the new strain differs significantly in base composition even from strain Kaplan, to…
Ethanol-type fermentation is one of three main fermentation types in the acidogenesis of anaerobic treatment systems. Non-spore-forming Ethanoligenens is as a typical genus capable of ethanol-type fermentation in mixed culture (i.e. acetate-ethanol fermentation). This genus can produce ethanol, acetate, CO2, and H2 using carbohydrates, and has application potential in anaerobic bioprocesses. Here, the complete genome sequences and methylome of Ethanoligenens harbinense strains with different autoaggregative and coaggregative abilities were obtained using the PacBio single-molecule real-time sequencing platform. The genome size of E. harbinense strains was about 2.97-3.10?Mb with 55.5% G+C content. 3020-3153 genes were annotated, most of which were methylated…
In 1995 a severe haemolytic-uremic syndrome (HUS) outbreak in Adelaide occurred. A recent genomic analysis of Shiga toxigenic Escherichia coli (STEC) O111:H- strains 95JB1 and 95NR1 from this outbreak found that the more virulent isolate, 95NR1, harboured two additional copies of the Shiga toxin 2 (Stx2) genes encoded within prophage regions. The structure of the Stx2-converting prophages could not be fully resolved using short-read sequence data alone and it was not clear if there were other genomic differences between 95JB1 and 95NR1. In this study we have used Pacific Biosciences (PacBio) single molecule real-time (SMRT) sequencing to characterise the genome…
Genome-wide analysis of DNA methylation patterns using single molecule real-time DNA sequencing has boosted the number of publicly available methylomes. However, there is a lack of tools coupling methylation patterns and the corresponding methyltransferase genes. Here we demonstrate a high-throughput method for coupling methyltransferases with their respective motifs, using automated cloning and analysing the methyltransferases in vectors carrying a strain-specific cassette containing all potential target sites. To validate the method, we analyse the genomes of the thermophile Moorella thermoacetica and the mesophile Acetobacterium woodii, two acetogenic bacteria having substantially modified genomes with 12 methylation motifs and a total of 23…
Clostridium spp. can synthesize valuable chemicals and fuels by utilizing diverse waste-stream substrates, including starchy biomass, lignocellulose, and industrial waste gases. However, metabolic engineering in Clostridium spp. is challenging due to the low efficiency of gene transfer and genomic integration of entire biosynthetic pathways.We have developed a reliable gene transfer and genomic integration system for the syngas-fermenting bacterium Clostridium ljungdahlii based on the conjugal transfer of donor plasmids containing large transgene cassettes (>?5 kb) followed by the inducible activation of Himar1 transposase to promote integration. We established a conjugation protocol for the efficient generation of transconjugants using the Gram-positive origins of…
Pear ring rot disease, mainly caused by Botryosphaeria dothidea, is widespread in most pear and apple-growing regions. Mycoviruses are used for biocontrol, especially in fruit tree disease. BdCV1 (Botryosphaeria dothidea chrysovirus 1) and BdPV1 (Botryosphaeria dothidea partitivirus 1) influence the biological characteristics of B. dothidea strains. BdCV1 is a potential candidate for the control of fungal disease. Therefore, it is vital to explore interactions between B. dothidea and mycovirus to clarify the pathogenic mechanisms of B. dothidea and hypovirulence of B. dothidea in pear. A high-quality full-length genome sequence of the B. dothidea LW-Hubei isolate was obtained using Single Molecule…


Does top-down information about speaker age guise influence perceptual compensation for coarticulatory /u/-fronting? Georgia Zellou, Linguistics Department, University of California, Davis, Davis, California, United States Michelle Cohn, University of California, Davis, Davis, California, United States Aleese Block, UC Davis, Davis, California, United States AbstractThe current study explores whether the top-down influence of speaker age guise influences patterns of compensation for coarticulation. /u/-fronting variation in California is linked to both phonetic and social factors: /u/ in alveolar contexts is fronter than in bilabial contexts and /u/-fronting is more advanced in younger speakers. We investigate whether the apparent age of the speaker, via a guise depicting a 21-year-old woman or a 55-year-old woman, influences whether listeners compensate for coarticulation on /u/. Listeners performed a paired discrimination task of /u/ with a raised F2 (fronted) in an alveolar consonant context (/sut/), compared to non-fronted /u/ in a non-coronal context. Overall, discrimination was more veridical for the younger guise, than for the older guise, leading to the perception of more inherently fronted variants for the younger talker. Results indicate that apparent talker age may influence perception of /u/-fronting, but not only in coarticulatory contexts.
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Abstract: Thermal transient response of internal combustion engines (ICEs) canenormously be improved by maintaining desired temperatures of coolantcirculating in engine cooling system. Thus, fuel consumption and tailpipeemissions can be significantly reduced. Computer controlled servo actuatorsare the main components of advanced automotive thermal management systems.It is evident that desired thermal conditions can be achieved when allelectrically controlled actuators function in harmony. In this paper,various control techniques are proposed for implementation on hydraulicactuated automotive cooling systems where they were never found in theliterature implemented on such systems. A neural network optimalcontrol (NNOC) and a sliding mode control (SMC) are designed and introducedto examine transient temperature tracking while minimize the smartcomponents' power consumption of thermal management system. Representativenumerical simulations are introduced to demonstrate the functionality of theproposed control schemes in accurately tracking prescribed temperatureprofiles.
Keywords: NN optimal control, sliding mode control, temperature control, hydraulic actuated cooling system


Browse the document links below to better understand the DBC Concussion Protocol.
Adapted from: Parachute. Canadian Guideline on Concussion in Sport. www.parachute.ca/concussion
Dragon Boat Canada (DBC) has developed the DBC Concussion Protocol to help guide the management of athletes who may have a suspected concussion as a result of participation in dragon boat activities.
Purpose This protocol covers the recognition, medical diagnosis, and management of sport participants who may sustain a suspected concussion during a sport activity. It aims to ensure that athletes with a suspected concussion receive timely and appropriate care and proper management to allow them to return back to their sport safely. This protocol may not address every possible clinical scenario that can occur during sport-related activities but includes critical elements based on the latest evidence and current expert consensus. Who should use this protocol? This protocol is intended for use by all individuals who interact with athletes inside and outside the context of organized sports activity (school and non-school based), including athletes, parents, coaches, officials, teachers, trainers, and licensed healthcare professionals.
For a summary of the DBC Concussion Protocol please refer to the DBC Sport Concussion Pathway figure at the end of the document linked below.


A research team led by Dr. Stefan Strauf, who serves as the Director of the NanoPhotonics Laboratory (NPL) at Stevens Institute of Technology, has developed a new method based on holographic lithography (HL) process for producing plasmonic nanogap arrays, which are evenly placed metallic nanostructures.
The novel method enhances the production of plasmonic nanogap arrays, while concurrently decreasing expenditure and setup. Existing nanogap array production methods are time-consuming and expensive and have low output.
Plasmonic nanogap arrays have small air gaps between them. By generating strongly controlled electrically fields using optical illumination, these small air gaps enable researchers to utilize the arrays in numerous applications, including ultra-sensitive sensing and photonic circuit miniaturization. Such sensors could be utilized in high-resolution microscopy or are useful in determining the presence of certain chemicals or proteins at single molecule level. Nanophotonic circuits, which can transfer large quantities of data, are critical in future-generation computing power.
HL, an optical method that produces periodic patterns using interference patterns of laser beams, was earlier utilized for the formation of sub wavelength features. The research team upgraded the HL process by coupling the compound lattice concept and four-beam interference to produce tunable twin motive patterns into a polymer template, yielding metallic nanostructures with air gaps as low as 7 nm, which is 70 folds lesser than the blue laser light wavelengths used to create the features.
The researchers scaled up the usage of HL method to form gaps with yields equivalent to that of painstaking serial production methods such as focused ion beam milling or electron beam lithography. Their method is not only easier and economical but does not need a clean room. At present, the unique method attains 90% consistency in the array pattern. It realizes the rapid and economical production of large-scale superior-quality arrays.
Source: http://www.stevens.edu


Abstract
The COVID-19 crisis has affected everyone, especially elementary school-aged children who might be too young to fully understand the sudden changes in familiar social norms as well as the unprecedented pandemic-induced educational context. This article is based on a case study that explores the perspective of the experiences of ten parents of elementary school children in French Immersion programs from different school boards during the March–June 2020 schools’ closure in Alberta. The findings show that parents had a special concern for the mental health of their children during the transition into lockdown and the ramifications of such experiences in the future as students return to school at the start of the academic year under a different climate. This includes adapting to new social norms and a certain apprehension of how school hygiene and safety measures in place will prevent a new coronavirus outbreak in schools.


Mr TARZIA (Hartley) (15:17): Today, I bring to the house's attention a significant local issue in my community, namely, that concerning the development of the former Magill Training Centre site. This proposed development continues to raise significant concerns within the local community, including the residents of Magill.
I attended a recent community meeting with local residents and community leaders, including the member for Morialta, on Thursday 12 May at the Rostrevor College Pavilion, and it was at times a loud meeting, let me tell you. Many residents were rightly furious about the arrogance of the current government and its failure to address the challenges which this proposed development will present. Over 115 residents attended. I note that neither the Minister for Planning, the Minister for Transport nor the Minister for Road Safety attended the meeting. The only gentleman, in fact, who attended on behalf of the government was Mr Paul Gelston, a very capable man who I am sure will have reported to his minister the severe levels of concern in the area.
It was back in 2009 that the state government decided to flog off the site. Since then, since 2011 and 2012, hundreds of residents have attended an array of public meetings, putting forward various valid propositions. In the state government's complete arrogance, a ministerial DPA was released right near Christmas 2013, ignoring most of the community's feedback. Land division was submitted with the local Adelaide Hills Council in July 2015.
In a joint venture between Starfish Developments and Devine Limited, we have now learnt that the DAC has approved close to 400 developments at the site. I note that a number of regulated trees, even eight significant trees, are proposed to be removed. An array of issues were raised at the meeting, as you can understand, notably the inappropriate increase to near 400 homes from 250. Whilst the government has already allowed that, it does have the power to change other aspects which affect the development.
Before I was elected as the member for Hartley, I lobbied, and now as the member for Hartley I continue to lobby for improvements to our area to make it the best that it can be. The state government has the budget, and not only the budget but the capacity, to improve the transport solutions surrounding the site. These include cycling infrastructure and public transport infrastructure, as well as improvement of key roads and intersections that have issues now, even before the traffic of 400 dwellings hits the area.
As reiterated by the feedback received from local residents in the local traffic survey I recently sent out—and I thank the hundreds of residents who sent in their surveys—the increase of 400 dwellings to the site will increase traffic by thousands of movements every day. Various intersections will be negatively impacted by the development, including Glen Stuart Road and Moules Road, Moules Road and St Bernards Road, and Magill Road and Norton Summit Road. Additionally, roads such as Koongarra Avenue, Edward Street and surrounding streets will have dramatically increased volumes.
Along with the member for Morialta I wrote to the Minister for Transport in December 2015 to alert him to these issues. The minister must now escalate these concerns. With the state government to receive over $50 million from the sale of the site it simply cannot bank a tonne of cash from developers and ignore the concerns of my residents. The state government must implement a road traffic management plan, it must allocate funding for these problem intersections and roads. I will continue to lobby the state government on this issue, because my residents demand and deserve action to be taken.


The 2018 Washington State Legislature directed WSIPP to assess the impact of changes to the Juvenile Justice Act (JJA), as outlined in E2SSB 6160. To the extent possible, the study should include impacts to community safety, racial disproportionality, recidivism, state expenditures, and youth rehabilitation.
The 2019 Legislature amended WSIPP’s assignment to include an assessment of additional components contained in Sections 2-6 of E2SHB 1646. WSIPP must also conduct a benefit-cost analysis which includes the health impacts and recidivism effects of extending the JJA to include all offenses committed under the age of twenty-one.
A preliminary report is due to the legislature by December 1, 2023 with a final report due December 1, 2031.
Lauren Knoth, (360) 664-9805
View Legislation


Abstract
Optical input/output interfaces between silicon-on-insulator (SOI) waveguides and optical fibers, allowing robust, costeffective and low-loss coupling of light, are fundamental functional elements in the library of silicon photonic devices. Surface grating couplers are particularly desirable as they allow wafer-scale device testing, yield improved alignment tolerances, and are compatible with state-of-the-art integration and packaging technologies. While several factors jointly contribute to the coupler performance, the grating directionality is a critical parameter for high-efficiency fiber-chip coupling. To address this issue, conventional coupler designs typically call upon comparatively complex architectures to improve light coupling efficiency. Increasing the intrinsic directionality of the grating by exploiting the blazing effects is another promising solution. In this paper, we report on our recent advances in development of low-loss grating couplers that afford excellent directionality, close to the theoretical limit of 100%. In particular, we demonstrate, by theory and experiments, several implementations of blazed grating couplers with layout features that are compatible with deepultraviolet (deep-UV) optical lithography. Devices can be advantageously implemented on various photonic platforms, including industry-specific and the offerings of publicly accessible foundries. The first experimental realizations of uniform deep-UV-compatible couplers yield losses of -2.7 dB at 1.55-µm and a 3-dB bandwidth of 62 nm. A subwavelength-index-engineered impedance matching transition is used to reduce back-reflections down to -20 dB.


This drug belongs to a class of drugs called DPP-4 inhibitors. A class of drugs refers to medications that work similarly. They are often used to treat similar conditions.
Normally, hormones are released into your bloodstream as you start to eat. They cause insulin to be released into your bloodstream, which helps pick up and store the carbohydrates and sugar from the meal. Alogliptin helps these hormones to continue the release of insulin to help lower your blood sugar levels.


Carbon Capture and Storage Consultation Launched
The Department for Business, Enterprise and Regulatory Reform has launched a consultation on the future of Carbon Capture and Storage.
A burgeoning population and consequent increase in demand for energy means that meeting global, national and regional carbon emission reduction targets will become increasingly difficult. In response, the government has proposed to build additional coal-fired power stations to meet the growing demand for energy. However, these proposals have been met with fierce criticism from environmental campaigners and leading scientists such as the President of the Royal Society, as the government’s commitment to energy supply is not presently concomitant with appropriate measures to reduce carbon emissions using carbon capture and storage technology.
The consultation document seeks a range of perspectives on various components of the regulation of Carbon Capture and Storage. Specifically, the document will consult on aspects of the proposed EU Directive on the Geological Storage of Carbon Dioxide and welcomes views on the principle of ‘carbon capture readiness’ for combustion plants and the regulation of Carbon Dioxide storage.
BES members are invited to take part in the consultation response, and contributions are strongly welcomed from readers of the blog.
Like what we stand for?
Support our mission and help develop the next generation of ecologists by donating to the British Ecological Society.


If you were lost or unsure of which direction to move in, would your rather have a map or a compass? Obviously both would be ideal. Let me suggest that a map is like a goal. It shows you where you can go but it is static. A compass points the direction. A compass is like a value. Goals can change frequently and need adjusting based on performance. Values tend to be more permanent. You may have reached your goals in 2016 and need to reset them for 2017. Values don’t need the same adjustment. If honesty and hard work were values for you in 2016, they will likely remain for 2017.
My suggestion for 2017 is that you review your goals and clarify your values. Look at your goals through the filter of your values. What is really important to you? Which values do you hold dearly? Which values help you to clarify everything you do? Which values do you hold so firmly that you would resign rather than violate them?
You need a map and a compass for 2017.


This education activity is intended for GPs only.
Despite the complexities associated with this population, GPs are ideally placed to engage with patients presenting with borderline personality disorder (BPD). This education session provides an outline of how the GPs can provide effective support and treatment options for these patients.
At the end of this session GPs will be able to:
Please note: This education session will follow SAPMEA’s social distancing measures. See our COVID-19 protocols page for full information. Event details
Tuesday, September 22
6:00pm - 08:30pm Location Name Sage Hotel - 208 South Tce, Adelaide SA 5000 Presented By Dr Cathy Ludbrook Psychiatrist
This event has already occured.
If you have any questions about it, please contact-us.


Abstract
The gastrointestinal peptide hormone gastrin is responsible for initiating the release of gastric acid in the stomach in response to the presence of food and/or humoral factors such as gastrin releasing peptide. However, it has a role in the growth and maintenance of the gastric epithelium, and has been implicated in the formation and growth of gastric cancers. Hypergastrinemia resulting from atrophic gastritis and pernicious anemia leads to hyperplasia and carcinoid formation in rats, and contributes to tumor formation in humans. Additionally, gastrin has been suspected to play a role in the formation and growth of cancers of the colon, but recent studies have instead implicated gastrin processing intermediates, such as gastrin-17-Gly, acting upon a putative, non-cholecystokinin receptor. This review summarizes the production and chemical structures of gastrin and of the processing intermediate gastrin-17-Gly, as well as their activities in the gastrointestinal tract, particularly the promotion of colon cancers.
All Science Journal Classification (ASJC) codes Structural Biology Biochemistry


Before every summer and winter, the Electric Reliability Council of Texas (ERCOT) forecasts potential electricity demand and capacity. If it appears that customer demand will exceed supply, ERCOT will initiate its Energy Emergency Alert (EEA) system.
Although most of these alerts call for energy conservation, ERCOT may call a statewide power emergency that could result in "rotating outages"—controlled, planned service interruptions designed to ensure grid stability.
We anticipate that there will be sufficient generation to meet peak customer demand this summer and work closely with state and local officials to prepare for increased demand. But, we are always prepared if ERCOT must declare a power emergency.
Here's what you can expect if ERCOT calls a power emergency:
If ERCOT requires CoServ to lower the demand on its system, it will result in rotating outages. These outages will only last 15-20 minutes per neighborhood.
If you're signed up for outage alerts, you'll receive a text or email indicating an outage at your residence. Our system automatically assesses a 2-hour estimated restoration time so we recommend visiting our outage map to ensure if you're experiencing a rotating outage. If so, you'll see a red box over our service territory with a red message indicating that mandated rotating outages are in effect. You will still receive a notification when power has been restored.
Please report any outages lasting longer than 25 minutes while rotating outages are in effect.
We want to keep the grid secure during these hot summer months. Want to do your part to conserve energy this summer? Check out our Energy Saving Tips!


Abstract
The Nougaret form of dominant stationary night blindness is linked to a G38D mutation in the rod transducin-α subunit (Tα). In this study, we have examined the mechanism of Nougaret night blindness using transgenic mice expressing TαG38D. The biochemical, electrophysiological, and vision-dependent behavioral analyses of the mouse model revealed a unique phenotype of reduced rod sensitivity, impaired activation, and slowed recovery of the phototransduction cascade. Two key deficiencies in TαG38D function, its poor ability to activate PDE6 (cGMP phosphodiesterase) and decreased GTPase activity, are found to be the major mechanisms altering visual signaling in transgenic mice. Despite these defects, rod-mediated sensitivity in heterozygous mice is not decreased to the extent seen in heterozygous Nougaret patients.
Keywords G-proteins Night blindness Photoreceptor Phototransduction Retina Transducin ASJC Scopus subject areas Neuroscience(all)


Active Smoking - significantly increases the risk of infertility in both men and women.
Due to the toxins from cigarettes, smokers are more likely to suffer from miscarriage than non-smokers. In addition, smoking increases several health risks during pregnancy, such as
preterm labour and ectopic pregnancy,
Ovulation problems, Genetic issues, Damage to reproductive organs, Damage to eggs or premature menopause, Increased risk of cancer and increased risk of miscarriage.Smoking during fertility treatment - Smoking undermines the effects of fertility treatment.
Smoking during pregnancy - increases the chance of pregnancy loss.


APAC Wholesale Voice Carrier Market share to exceed USD 7 billion in 2026 and is set to register a lucrative growth between 2020 and 2026, growing at a CAGR of over 8%. The total voice traffic across APAC exceeded 200 billion minutes in 2019.
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The APAC market is witnessing a rapid telecom shift toward HD voice calling and VoIP technologies. CSPs and telecom service providers are increasingly purchasing wholesale voice carrier services to improve revenues and mitigate financial losses, creating new avenues for market expansion. Wholesale voice carrier services have increasingly gained market traction amid the ongoing COVID-19 pandemic as subscribers are making frequent and long-duration calls. Nations, such as India, Taiwan, Malaysia, and Hong Kong, are rapidly building a strong VoIP landscape amid the ongoing pandemic, which is expected to proliferate further as work from home and remote working trends continue to rise.
The interconnect billing segment is set to attain a CAGR of nearly 10% by 2026. Interconnect billing solutions are becoming mainstream as telecom enterprises look for convergent billing systems to accelerate their digital transformation strategies. Convergent billing solutions enable telecom operators to eliminate the dependency on multiple legacy billing platforms and lower the total cost of ownership.
The leased transmission network segment accounted for over 25% of market share in 2019, attributed to the growing uptake of leased network infrastructure for VoIP call termination across multiple geographical locations in the APAC. The highly competitive nature of the telecom industry has led to an increase in the number of tier-2 and tier-3 providers, who are increasingly leasing network capacities from tier-1 operators to reduce total cost of ownership and gain profitability.
The traditional switching segment held around 70% of the market share in 2019. This is attributed to the high use of traditional (non-VoIP) voice calls by subscribers in developing APAC nations due to the existing legacy infrastructure. In addition, expensive cellular internet and limited choice of unlimited data packs have also refrained several subscribers from switching to VoIP, thereby increasing market share of traditional switching technologies.
The wholesale voice carrier market in South Korea is expected to grow significantly with robust ICT Infrastructure. The advancements in the telecom industry and commercialization of 5G network services are anticipated to support the market growth. For instance, in April 2019, KT Corporation launched its first 5G commercial network with high reliable and rapid connectivity in South Korea. The company provides voice traffic wholesale services with call termination service and interconnection support to VoIP, TDM & IPX.
The APAC market has witnessed the launch of several new services by key players to leverage their wholesale voice infrastructure for capitalizing on new opportunities. For instance, in December 2019, Airtel launched Airtel Wi-Fi Calling, its VoIP service, across major cities in India. Though this service, customers can benefit from enhanced calling experience at free of cost. In May 2018, Airtel launched its innovative voice platform that offers quick voice interconnects and real-time traffic analytics for global carriers across the world. The company also uses this platform for offering wholesale voice carrier services.
Some of the leading companies operating in the market include Alepo, AT&T, Inc., Bharti Airtel Ltd., BICS SA, BT Group Plc, CenturyLink, Inc., China Telecommunications Corporation, CITIC Telecom International Holdings Limited, Comarch SA, Deutsche Telekom AG, Emirates Telecommunication Group Company PJSC (Etisalat), Globitel, IDT Corporation, NTT Corporation, Orange SA, Singapore Telecommunications Limited, Sprint (T-Mobile), Tata Communications Ltd., Telenor ASA, Telstra Corporation Ltd., Verizon Communications Inc., and Vodafone Group Plc.


This report highlights recent data that show, from 2007 to 2014, the preterm birth rate decreased for all age groups, and the overall birth rate for teens and women aged 20-24 years also decreased. The changing distribution of maternal age might indicate success of programs to prevent teen and unintended pregnancies.


People often have to queue for a busy service in many places around a city, and knowing the queue time can be helpful for making better activity plans to avoid long queues. Traditional solutions to the queue time monitoring are based on pre-deployed infrastructures, such as cameras and infrared sensors, which are costly and fail to deliver the queue time information to scattered citizens. This paper presents CrowdQTE, a mobile crowdsensing system, which utilizes the sensor-enhanced mobile devices and crowd human intelligence to monitor and provide real-time queue time information for various queuing scenarios. When people are waiting in a line, we utilize the accelerometer sensor data and
ambient contexts to automatically detect the queueing behavior and calculate the queue time. When people are not waiting in a line, it estimates the queue time based on the information reported manually by participants. We evaluate the performance of the system with a two-week and 12-person deployment using commercially-available smartphones. The results demonstrate that CrowdQTE is effective in estimating queuing status.


The global crisis due to the coronavirus COVID-19 in 2020 is unique in world history in its scale and impact. We need to overcome this crisis, but we also need to understand how best to help the individuals experiencing it, at all scales. We need to understand the social, mental health, and crisis management impacts…
Read more


AEGIS has designed and implemented the AEGIS Advanced Visualization Toolkit that is an extensible software with a wide application scope, ranging from Digital Forensic Analysis to Big Data analytics.
The AEGIS Advanced Visualisation Toolkit provides an extensible platform for data visualization and transformation. It is a versatile solution that can use different visualization techniques to cover the needs of IT experts as well as non-IT literate users. Via its intuitive monitoring dashboards, configurable visual representations and collaboration features, the toolkit serves as an advanced system that can support easy exploration and insight gaining from big volumes of multidimensional data.
AEGIS Advanced Visualization Toolkit (AVT) is a set of specialized tools that can turn input data into meaningful insights through creative visualizations. Key features include:
Visualizations of both batch data analytics and streaming analytics Processing of large and complex data sets Addressing needs of experts and non-IT experts Multiple Granularity in data representations Advanced visualisations that include dynamic real-time graphs, spatiotemporal representations (interactive maps, etc) apart from traditional charts (pie, bar, etc) Extensibility and customization for specific needs and requirements Powerful User & Access Management Business and industry Data-driven and decision-wise SMEs and large enterprises Domain-agnostic solution Digital economy Information technology, services, research and retail etc.
Tangibly validated in telecommunication, banking and manufacturing sectors and relative use-cases.
The Data Visualization Market is expected to have a significant growth (reach $ 19.20 Billion by 2027, based on Business Insights report) that accounts of the increasing inclination towards visual analytics, scientific visualization, and information visualization by various enterprises. The increasing adoption of data visualization in small and medium enterprises is expected to fuel the growth of the data visualization market that AEGIS AVT competes.
The incorporation of
internet of things (IoT) in all aspects of business is adding to the increase in the number of data. The rising need for decisions to be made in a short span of time requires tools to help derive analytical information from large chunks of unorganized data in a quick turn-around time. Technological advancements and flexibility in business intelligence solutions are paving the need for data integration and data analysis across varied industry sectors, this has led to the growing requirements of data visualization software for graphical representation purposes.
The market faces intense competition with many open source and proprietary offerings. The major differentiation factors of AVT offering are the specialized visualization needs of niche target market, the interactive visualization that supports and enhances the user’s insights and ease-of-use functionality that address the needs of experts and non-expert personnel.
The emerging nature of data visualization is encouraging a shift toward analytically driven businesses, where users can explore data in various forms of graphical representation, which were initially only available in tabular reports. Growth in big data, IoT and IIoT, customized reports for specific roles, ongoing training for business users, and constantly changing optimizing dashboards are the main benefits of AEGIS AVT offering. Moreover, factors, such as the shortage of skills, budget restraints and the lack of technical skills for report creation and data analysis, are highlighting the need for adoption of visualization tools, tailor-made for the specialized needs of data-driven domains.
AEGIS AVT is designed with modularity and scalability in mind, offering multidisciplinary, intuitive and effective visualization and interaction capabilities for the end-users. Several types of programming languages and advanced visualization tools have been used to develop a platform easy-to-use for experts and non-expert users. The agnostic-domain nature of AVT allows the user to grasp information and insights from o large amount of data with ease. AVT also helps decision-makers to identify focus areas between multi-dimensional data-sets and offers effective features and tools to interpret the data.


The success of any test involving fluorescence (LPI, MPI, contamination, etc.) is based on having sufficiently high UV intensity and low visible light intensity for optimum contrast. All relevant NDT Codes stipulate these values.
It should be noted that legacy Mercury vapor lamps decrease in intensity with age, use and contamination. This results in a decrease in intensity over time. We offer Radiometers (UV Meters) and Photometers (Visible Light Meters) from Spectronics, Baugh & Weedon, Gould-Bass, UV Products, Magnaflux and our Economical House Brand.


Abstract
Induced responses to insect herbivory are a common phenomenon in the plant kingdom. So far, induced responses have mostly investigated in aerial plant parts. Recently it was found that root herbivore may also elicit both local and systemic responses affecting aboveground herbivores and their natural enemies. Using broccoli (Brassica oleracea subsp. italica L.) and turnip (Brassica rapa subsp. rapa L.), two cultivated brassicaceaous plants differing in their chemistry and morphology, we analysed the local and systemic induced responses triggered by Delia radicum L. damage, JA and SA application. We also assessed whether the root induction treatments affected D. radicum larval performance. Both D. radicum damage and JA induced changes in glucosinolate and sugar content as well as affected D. radicum performance, while SA application did not. Despite the uniform chemical responses, the effect on larval performance on broccoli and turnip plantswas very different. On broccoli, JA root treatment reduced herbivore performance, whereas in turnips the same treatment enhanced it. JA- and D. radicum-induced responses followed similar patterns, which suggests that the JA signalling pathway is involved in rootinduced responses to larval feeding. Glucosinolate induction cannot fully explain the differences found in the performance of D. radicum on the different species. Changes in other resistance factors might significantly contribute to the induced resistance in these brassicaceaeous species as well.
Keywords international


In this work, we present a theoretical analysis framework for relational ensemble models. We show that ensembles of collective classifiers can improve predictions for graph data by reducing errors due to variance in both learning \emph{and} inference. In addition, we propose a relational ensemble framework that combines a relational ensemble learning approach with a relational ensemble inference approach for collective classification. This combination allows the relational ensemble to reduce errors due to variance in both learning and inference. The proposed ensemble techniques are applicable for both single and multiple graph settings. Experiments on both synthetic and real-world data demonstrate the effectiveness of the proposed framework. Finally, our experimental results support the theoretical analysis and confirm that ensemble algorithms that explicitly focus on both learning and inference processes and aim at reducing errors associated with both, are the best performers.Learn More


Abstract
Background: Budgetary restrictions and shorter hospital admission times have increased demands upon nursing time leading to nurses missing or rationing care. Previous research studies involving perceptions of missed care have predominantly occurred outside of Australia. This paper reports findings from the first South Australian study to explore missed nursing care. Aim: To determine and explore nurses' perceptions of reasons for missed care within the South Australian context and across a variety of healthcare settings. Method: The survey was a collaborative venture between the Flinders University of South Australia, After Hours Nurse Staffing Work Intensity and Quality of Care project team and the Australian Nursing and Midwifery Federation, SA Branch.Electronic invitations using Survey Monkey were sent to randomly selected nurses and midwives and available online for two months. Three hundred and fifty-four nurses and midwives responded. This paper reports qualitative data from answers to the open questions. Findings: Three main reasons for missed care were determined as: competing demands that reduce time for patient care; ineffective methods for determining staffing levels; and skill mix including inadequate staff numbers. These broad issues represented participants' perceptions of missed care. Conclusion: Issues around staffing levels, skill mix and the ability to predict workload play a major role in the delivery of care. This study identified the increasing work demands on nurses/midwifes. Solutions to the rationing of care need further exploration.
Keywords Missed care Nursing and midwifery Rationed care Skill mix Staffing


Electronic Thesis/Dissertation Development of a Novel DNA Break Capture Method to Study the Repair Dynamics of Topoisomerase-DNA Lesions Open Access Downloadable ContentDownload PDF
The last decades have seen major advances in our understanding of how DNA breaks are detected, signaled to cell-cycle checkpoints, and repaired. However, a more complete understanding of how the genomic landscape influences DNA double strand break (DSB) generation and repair is needed. To address these challenges, we have developed a new method, END-seq, to measure DSBs and DNA end-resection genome-wide at base-pair resolution in vivo. By providing a snapshot of DSBs genome-wide at a given time in a population of cells, END-seq can be utilized to study the causes and consequences of genomic instability, as well as the influence of chromatin on DNA damage response. We utilized END-seq to first determine the frequency and spectrum of restriction-enzyme, zinc-finger-nuclease, and RAG-induced DSBs, and then to study the repair dynamics of topoisomerase-induced lesions. Topoisomerase II (TOP2) relieves topological stress in DNA that arises during physiological processes by introducing double strand breaks (DSBs) via a transient intermediate that contains a covalently linked DNA-bound TOP2 molecule (TOP2cc). This structural state is normally rapidly reversible, but can be stabilized by TOP2 poisons, such as the chemotherapeutic agent Etoposide (ETO), which traps TOP2ccs on DNA. Cells are thought to remove trapped TOP2ccs primarily by proteolytic degradation followed by DNA DSB repair. However, ETO is a highly reversible drug which does not permanently inhibit the enzymatic function of TOP2. Therefore, we wanted to explore if inhibiting the proteasome created conditions where TOP2cc reversibility is favored over DSB repair upon ETO washout, and what impact suppressing proteasome mediated repair of TOP2 DNA-protein adducts would have on genome stability. Here, we show that proteasome inhibitors when used in conjunction with ETO can both potentiate and suppress the genotoxic effects of ETO, depending on what order the drugs are added to the cells. Pre-treating cells with proteasome inhibitors prevented the proteolytic processing of trapped TOP2ccs, which completely protected cells from ETO-induced genome instability and preserved cellular viability, whereas treating cells with proteasome inhibitors after ETO did not. Furthermore, by preventing RNF4-mediated ubiquitination of TOP2ccs, proteasome recruitment was suppressed, which significantly enhanced genome integrity. Despite blocking DNA damage response (DDR) signaling to ETO-induced lesions, proteasome inhibitors did not prevent the formation of TOP2-linked DSBs. Rather, by suppressing the DDR to these DNA-protein adducts, TOP2 had time to uncouple itself from the DNA following ETO washout in an error-free manner that generated fewer genotoxic lesions compared to the canonical proteasome mediated repair response. Thus, inhibiting proteasome-based repair of TOP2-DNA adducts presents a possible mechanism of resistance to topoisomerase poisons.
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Traditionally, basil is appreciated mainly for its antispasmodic and digestive qualities.
Basil is a herbaceous plant, native to India, which can reach up to 60cm. It is grown all over the world and is mainly used as an aromatic plant. In India we revere the variety known as tulsi, or sacred basil, as a sacred plant.
The composition of its essential oil differs according to its geographical origin. Its therapeutic efficacy is not unanimous, however it is widely used throughout the world for a large number of ailments.
Properties of basil:
Basil will be useful in cases of
- difficult digestion
- inappetence - anxiety - bloating and flatulence - intestinal parasites - acne - insomnia of nervous origin - migraines of nervous origin - tonic of the nervous system (balance, does not stimulate) Main Benefits: Acne According to Indian scientists, basil oil is effective in destroying bacteria in the skin. This would make it effective in reducing acne (externally applied to the skin). Stimulates the immune system Animal research has demonstrated that basil produces an increase of 20% in antibody production. This would explain the reputation of this plant for fighting bacteria. Intestinal parasites Basil oil would be effective in eliminating intestinal parasites. It is used for this purpose, particularly in Malaysia. Young children and pregnant women should not be treated with basil oil. Digestion and antispasmodic The use of Basilis recommended by herbalists concerns the digestive, carminative and antispasmodic properties of the Basilisk. In the form of an infusion of leaves. (3 to 4 leaves per cup of water, let infuse for a few minutes, do not exceed 3 cups per day. Precautions
It is therefore not advisable to use the Basilisk in an abusive and prolonged manner, especially in the form of essential oil.
Instructions for use
Internal use: 1 dessert spoonful per cup of hot water. Let infuse 5 to 10 minutes. Drink one to three cups a day, after meals.
Essential oil: 3 to 5 drops in a little honey. Do not abuse the use of basil in the form of essential oil.


Workers’ Compensation
payout will be. Does your employer still send you a paycheck? Does the money come from the insurance company? The following are some basics in receiving a payout while receiving medical treatment and recovering from your injury or illness.
Open Claims
Claims vary by state and occupation, with some offering more of a payout and others offering less. If your claim is open, the payout received will typically depend on the severity of your injury and whether you’ll be heading back to work any time soon. Even if you can safely complete lighter duty work, for the time being, it is considered going back to work, so your payout from workers’ compensation may not be as great.
Closed Claims
In most cases, injured workers do not receive any type of payout after the claim is closed. Though that is the case for most situations, there are some exceptions. First, someone who has a permanent disability could receive a pension. Second, someone with a partial permanent disability could continue to receive a weekly payout. Finally, an individual who enters a structured settlement would receive funds following the claim closure.
Time Loss Compensation
Temporary disability benefits are given in the form of time-loss compensation. They are paid out periodically and typically cover 66.67% of your average weekly wage. Unfortunately, it’s not the same amount you are used to receiving in a typical paycheck, but it’s a great benefit if you were injured at work. This payout may come to you twice each month, though each state varies on the frequency. You might receive a check every week, or possibly only once every month.
Loss of Earning Power
One benefit of workers’ compensation is Loss of Earning Power. This is given to individuals who are injured to the point they can’t perform their typical duties, but who can perform a job in a lower-paying position. The employer would pay the employee a portion of the difference between the two positions’ wages. The payment would come through workers’ compensation.
Receiving Assistance
When you are injured on the job, you may not know where to start. When should you report your injury? How do you file a claim with the insurance company? When will you receive your payout, and for what? Contacting a workers’ compensation attorney, like a New Jersey workers’ compensation attorney, is one of the best ways to find answers to these questions. Contact an attorney today.
Thanks to Rispoli & Borneo, P.C. for their insight into how workers’ compensation pay works.


A survey shows that men enjoy on average 40 minutes more leisure time than women.
For both sexes the number one leisure activity was consuming mass media which constitutes watching TV, reading or listening to music.
The work-life balance study was carried out by the Office of National Statistics (ONS) in the U.K.
On average men spend six hours and nine minutes per week on leisure pursuits compared to five hours and 29 minutes for women.
The study found that women were more likely then men to perform unpaid work. Unpaid work was classified in the study as childcare, adult care, volunteering, cooking, cleaning, washing clothes, ironing, giving lifts to others, gardening and DIY.
Women were also found to be more sociable then men, the study found that they spent four hours and 19 minutes per week, compared with three hours and two minutes for men.
The study shows that on average 16 to 24-year-olds enjoy six hours of leisure time per week the same as those aged between 55-64.
The highest leisure time per week–seven hours and 10 minutes–was reserved for those aged 65 and over.
While 25 to 34-year-olds had the least amount of leisure time at just four hours and 46 minutes per week.
The study revealed that those who worked in skilled-trade professions spent the least time on leisure just four hours and 34 minutes per day. This figure is compared with people in sales and customer services professions who spent the most at five hours and 21 minutes per day, report The Guardian .


Optical coherence tomography (OCT) has gained wide adoption in biological research and medical imaging due to its exceptional tissue penetration, 3D imaging speed and rich contrast. However, OCT plays a relatively small role in molecular and cellular imaging due to the lack of suitable biomolecular contrast agents. In particular, while the green fluorescent protein has provided revolutionary capabilities to fluorescence microscopy by connecting it to cellular functions such as gene expression, no equivalent reporter gene is currently available for OCT. Here we introduce gas vesicles, a class of naturally evolved gas-filled protein nanostructures, as genetically encodable OCT contrast agents. The ...


Vietnamese potato supply fails to meet demand
Vietnam has favourable condition to grow potatoes, with supply abundant in many localities. However, domestic potato processing firms are facing supply shortages.
In 2018, Orion Vina confectionery Company needs 18,000 tonnes of potato. To ensure local potato supply, the company has collaborated with 15,000 potato farms nationwide. However, they can only meet 40 percent of the company’s need.
Orion Vina’s demand for potato supply will increase in the future. Specifically, in the next two years, it needs up to 22,000 and 25,000 tonnes of potato each.
Vietnam produces 350,000 tonnes of potato each year. However, only 100,000 tonnes can be used for processing. Therefore, numerous companies are importing potato for processing.
Vietnam now has only three varieties of potato suitable for processing.
The potato crop lasts for only three months in the winter. It is necessary to create potato varieties which are more heat-resilient to ensure potato supply throughout the year./.


The difference in proton radii measured with $\mu p$ atoms and with $ep$atoms and scattering remains an unexplained puzzle. The PSI MUSE proposal is tomeasure $\mu p$ and $e p$ scattering in the same experiment at the same time.The experiment will determine cross sections, two-photon effects, form factors,and radii independently for the two reactions, and will allow $\mu p$ and $ep$results to be compared with reduced systematic uncertainties. These data shouldprovide the best test of lepton universality in a scattering experiment todate, about an order of magnitude improvement over previous tests. Measuringscattering with both particle polarities will allow a test of two-photonexchange at the sub-percent level, about a factor of four improvement onuncertainties and over an order of magnitude more data points than previous lowmomentum transfer determinations, and similar to the current generation ofhigher momentum transfer electron experiments. The experiment has the potentialto demonstrate whether the $\mu p$ and $ep$ interactions are consistent ordifferent, and whether any difference results from novel physics or two-photonexchange. The uncertainties are such that if the discrepancy is real it shouldbe confirmed with $\approx$5$\sigma$ significance, similar to that alreadyestablished between the regular and muonic hydrogen Lamb shift.
We report on new p$(e,e^\prime p)\pi^\circ$ measurements at the$\Delta^{+}(1232)$ resonance at the low momentum transfer region. The mesoniccloud dynamics is predicted to be dominant and rapidly changing in thiskinematic region offering a test bed for chiral effective field theorycalculations. The new data explore the low $Q^2$ dependence of the resonantquadrupole amplitudes while extending the measurements of the Coulombquadrupole amplitude to the lowest momentum transfer ever reached. The resultsdisagree with predictions of constituent quark models and are in reasonableagreement with dynamical calculations that include pion cloud effects, chiraleffective field theory and lattice calculations. The reported measurementssuggest that improvement is required to the theoretical calculations andprovide valuable input that will allow their refinements.
We present an up-to-date, comprehensive summary of the rates for all types ofcompact binary coalescence sources detectable by the Initial and Advancedversions of the ground-based gravitational-wave detectors LIGO and Virgo.Astrophysical estimates for compact-binary coalescence rates depend on a numberof assumptions and unknown model parameters, and are still uncertain. The mostconfident among these estimates are the rate predictions for coalescing binaryneutron stars which are based on extrapolations from observed binary pulsars inour Galaxy. These yield a likely coalescence rate of 100 per Myr per Milky WayEquivalent Galaxy (MWEG), although the rate could plausibly range from 1 perMyr per MWEG to 1000 per Myr per MWEG. We convert coalescence rates intodetection rates based on data from the LIGO S5 and Virgo VSR2 science runs andprojected sensitivities for our Advanced detectors. Using the detectorsensitivities derived from these data, we find a likely detection rate of 0.02per year for Initial LIGO-Virgo interferometers, with a plausible range between0.0002 and 0.2 per year. The likely binary neutron-star detection rate for theAdvanced LIGO-Virgo network increases to 40 events per year, with a rangebetween 0.4 and 400 per year.


Zero Tolerance is an initiative led by National Disability Services in partnership with the disability sector. REAL has adopted a continuous improvement approach to ensure a Zero Tolerance culture is integral to the organisation’s practices and policies
Zero Tolerance aims to assist disability service providers to understand, implement and improve practices which safeguard the rights of people they support.
This evidence-based framework outlines strategies for service providers to improve prevention, early intervention and responses to abuse, neglect and violence experienced by people with disability. An expanding range of Zero Tolerance tools and resources for the disability sector are available to support broader safeguarding approaches for people with a disability.
Formore information and resources read the
Zero Tolerance Framework orvisit https://www.nds.org.au/resources/zero-tolerance.


Addressing distribution equity in spatial conservation prioritization for small-scale fisheries Type:Journal Article Year of publication:2020 Date published:05/2020 Journal title:PLOS ONE Volume:15 Issue:5 Pages:e0233339
Spatial conservation prioritization is used worldwide for designing marine protected areas (MPA) that achieve set conservation objectives with minimal impacts to marine users. People involved in small-scale fisheries (SSF) may incur negative and disproportionate impacts from implementing MPAs, yet limited available data often restricts their representation in MPA planning. Using a Philippines case study, we focus here on the systematic design of a MPA network that aims to minimize and distribute costs equitably for SSF whilst achieving representation targets for biodiversity conservation. The objectives of the study are to: (1) document a participatory mapping approach for collecting SSF data for prioritization using the local knowledge of fishers; and (2) examine how the completeness and resolution of SSF data may affect prioritization outputs in terms of biodiversity representation, spatial efficiency, and distribution equity. In the data-poor region, we conducted participatory mapping workshops with fishers in 79 communities to collect data on the spatial distribution patterns of different SSF fisheries and communities, and employed remote sensing techniques to define coastal habitats, which were targeted for inclusion in MPAs. The datasets were integrated within the decision-support tool Marxan with Zones to develop three scenarios. The SSF data incorporated in each scenario varied based on their completeness (considered all fishing methods or only dominant methods) and resolution (fishing methods itemized by community or municipality). All scenarios derived MPA plans that met representation targets with similar area coverage. The outputs, however, varied in terms of distribution equity, measured by the distribution of opportunity costs (loss of fishing grounds) across different fisheries and communities. Scenarios that did not include minority fisheries or variations between communities, led to inequitable costs. These results highlight the need to incorporate detailed data on SSF at appropriate resolutions, and how this can be achieved through participatory approaches.


The development of treatment and preventive measures of neurological disorders is possible only if accurate estimates on incidence, prevalence, mortality, and disability are known. State-level estimates of neurological disorders in the US are not present. This study aims to determine the burden estimates of major neurological disorders.
This systematic analysis comprises data from the Global Burden of Disease (GBD) 2017 study. The researchers analyzed data on the incidence, mortality, prevalence, and disability-adjusted life years of major neurological disorders. 12 of these major disorders included Parkinson’s disease, epilepsy, Alzheimer’s disease, motor neuron disease, migraine, multiple sclerosis, cancers, meningitis, encephalitis, tetanus, tension-type headache, traumatic brain injury, and spinal cord injuries. The primary outcome of the study was actual numbers calculated by age-standardized rates.
The results suggested that stroke (3.58), Alzheimer’s disease (2.55), and migraine (2.40) were the most burdensome neurological disorders in the US. It was also found that the burden of all neurological disorders increased from 1990 to 2017. The only exceptions to this trend were traumatic brain injury incidence, spinal cord injury prevalence, spinal cord injury prevalence, and deaths.
The research concluded that there was a substantial burden of neurological disorders in the US, with the burden being the most significant for stroke, Alzheimer’s disease, and migraine.


It may sound obvious but caring for our feet often slips our mind and can put us at risk of having a fall.
Did you know that good vision helps prevent us from having a fall?
Our vision plays a key role in maintaining our balance and identifying hazards in our environment, so we can navigate around them. Continue reading “Healthy Eyes for Falls Prevention”


Legal Ramifications of Elderly Cohabitation: Necessity for Recognition of Its Implications by Family Psychotherapists
SUMMARY. This paper views cohabitation among the elderly from a legal perspective and presents realities of which many family practitioners may not be aware. Five key areas that the therapist and his or her clients should recognize will provide a foundation for under-
standin~ the responsibilities and potential legacy of the cohabitation. By deSign, this paper should contribute to the avoidance of the costly and unpleasant resort to legal suit. An appended list of 28 legally-oriented items should be considered at the outset of cohabitation.


I'm so excited to be sharing a different kind of post with you today! Over the last few months, I've been working really hard on my health and fitness routine. I preface this by saying I am not a doctor, dietitian, etc., but what I've been doing the last few months - eating right, working out five or more times a week - has really made me feel better.
Like many of us, come the new year, I always make a resolution to work out more. To be honest, I usually always fail. Back in my 20's I could eat whatever I wanted, not go to the gym, and I it didn't affect me
at all. I remember someone saying to me, "Just wait until you turn 30." Yeah, right I thought (insert eye-roll), but sadly, they were right. I definitely saw a change in my energy, metabolism and the fact that I couldn't have all those carbs I love so much without it being visible. I realized quickly I needed to start working out, and be more aware of what I eat. Even after I turned 30 though, I kept dipping my foot in, but not fully jumping in...until this year.
I think what gave me the extra push at the beginning of 2019 was that one of my favorite workout classes, The Bar Method, was having a 'New Year New You' (or something like that) challenge. The challenge was to do 20 classes in 30 days. Phew, it's a lot, and if you've ever done a barre class before, you know how hard they are. I thought to myself, I
wantto do this, I cando this. You know what, I did(!!!), and since then, I've signed up for and completed two more challenges.
The workout is a mix of yoga, pilates, and ballet. Not only is it great for strengthening and creating long lean muscles, but they focus a lot on stretching too, which is great for my arthritis. If you're new around here, I shared more about my journey with arthritis in a post a few years ago, which you can read here. I've seen my flexibility and mobility increase, and just have felt stronger. This is definitely not a sponsored post, although I'd happily welcome it (pst, Bar Method!). I truly just have found a workout that is perfect for me. I feel more confident, and I'm not talking confident in my appearance (although I definitely can see a difference). I'm more confident in my capabilities, myself, my work ethic, my commitment and my sense of community. When you work from home, it's nice to have that interaction at a gym/studio, and the ladies (and a few men), that go to Bar are great. The instructors at the Montrose studio are amazing, fun, and so encouraging, which is what keeps me coming back. An added bonus, it's perfect for all ages and skill levels!
I also mix in spinning/biking on our Peloton at home, and when it's not 100 degrees, my favorite form of exercise is walking. I could walk for forever if it was possible! It's true what they say, you just feel better after working out.
I found these great monthly exercise calendars (see below) from a fellow blogger, and they've really helped me hold myself accountable to getting in those five days a week. I'd love to hear what your favorite workout is and why. Be sure to stay tuned for health and wellness posts, too!


Each journey in our personal and professional lives will take us through the highs and the lows. If we only decide to celebrate once we get to the mountain top, then we’re not realizing the beauty in the journey itself. The joy of reaching the mountain top is a feat in itself. To make our lives more happy and meaningful, we should take the good with the bad.
I remember a time when a speaker at an event I attended many years ago said “
People are like plants: we need both sun and water to grow .“


Global Societies Journal The Battle for Development: Economic Growth versus Institutions, Fighting for Long-term Sustainable Outcomes Author(s): Brown, Hannah K. et al. Abstract
The globalization process, accelerated through technology proliferation, has “brought about profound changes in the international context [and] could have far-reaching implications for development” according to Deepak Nayyar. He argues a myth exists advocating the spread of globalization and global economic wealth convergence; however, globalization is uneven and a sharp divide between rich and poor countries persists. For example, during the 1980s and 1990s poverty increased in most Latin American, Caribbean, and Sub-Saharan African countries. However, not all developing nations have stagnated, some have experienced high sustained economic growth rates. Both China and Botswana have been hailed as such examples in the developing world while some of their neighbors, notably Mongolia and Zimbabwe, have had more trouble. This begs the question, why have some developing countries achieved development while others have not? To begin to address this question, one must look at various development models and case studies. Before trying to achieve rapid economic growth, it is critical that nations have strong institutions embedded within state infrastructure to ensure long-term sustainable development.


I dreamed I was walking with a group of 5 females, we were good friends and laughing while on a short weekend getaway. I felt soooooo happy. I woke up smiling.
I think I know what this one means, but please interpret. Thank you Mary Ann
Hi Mary Ann,
What a pleasant dream! While we often think that our dreams are prophetic as in foretelling the coming future, it isn't always the case. However, they do reflect our fears and desires.
The symbols in your dream (five females, good friends, laughing, weekend getaway, feeling happy) are all very positive. It will be a good thing for you to engage all of your five senses in relishing life (for example, taking care to appreciate the fragrance of a flower, inhale fresh air, gaze at beautiful things, savor flavors). Dreaming of friends often signals coming positive times or news.
Dreaming of a getaway tells you to do just that: take time out for a mini-escape from your waking life stresses. Your mind is telling you what you need, what your body is yearning for.
Laughing in your dream underscores your need to be unburdened from waking life stresses.
Perhaps you yearn for trusted, comfortable friendships. If you do have them in your waking life, be sure not to take them for granted. Set aside time to nurture them. This is not a luxury for you but a necessity, as serious as taking medicine for an ailment.
Positive social connections, laughter, getaways are incredibly healing. But don't wait until you are feeling beaten down before you reach for the elixir. An ounce of prevention is worth a pound of cure.


Abstract
Alopecia areata (AA) is the second most common cause of hair loss. It is crucial for the clinician to differentiate AA from other types of hair loss as it differs in prognosis and treatment. The diagnosis of AA can be made clinically; however, there are many nuances making an exact diagnosis challenging. This paper describes the differential diagnoses of both scarring and non-scarring hair loss that may mimic AA. It also highlights the diagnostic tests and pertinent findings that help distinguish AA from other types of hair loss.
Keywords alopecia areata alopecia totalis alopecia universalis dermoscopy diagnosis trichoscopy ASJC Scopus subject areas Dermatology


Edited by Kerry Mallam
You can also purchase the digital version of this publication.
Picture Books and Beyond examines a wide selection of picture books, graphics novels, films, e-picture books and apps that reflects the diversity of various evolving cultural artefacts, and their opportunities for education and delight. It aligns closely with the goals and directions of the Australian Curriculum: English, and considers the potential of texts for enabling students to respond critically and creatively. It also highlights links to other curricula, general capabilities, and cross-curriculum priorities.
Chapters are generously illustrated incorporating a range of relevant images from the picture books and other texts discussed by the contributors. Each chapter offers readings and interpretive opportunities through the complex interplay of words and images, narrative strategies, digital interactivity, or filmic adaptation in the sample texts. At the end of each chapter a list of 'Additional texts' is intended to lead readers to other useful examples that relate to the topics discussed.


In 2018, the European Commission adopted criteria to assess whether a biocide or pesticide is an endocrine disruptor. A guidance document was written on how to do this in practice. In this webinar, FREIA partner Julie Boberg (Technical University of Denmark) will explain the process of ED identification, using butylparaben as an example.
Butylparaben is often used in cosmetics to prevent microbial growth. It is on the candidate list of substances of very high concern of the European Chemicals Agency for its endocrine disrupting properties. Not only will Ms Boberg show that butylparaben has more negative effects on reproduction than previously thought, but she will also explain how this substance is a great example of how current criteria and EDC identification tools may also be suitable for other chemical regulations. This webinar is organised by the FREIA project, with support from the Health and Environment Alliance (HEAL). Participation is free. For more details, please contact info@freiaproject.eu


The power of self reflection is profound. Without checking back deep within ourselves and listening to what is happening within, we cannot grow and prosper. We might remain slaves to what we have been taught to feel, to sense, to think. Yet we are slaves without shackles. Nothing is truly bounding us, but..
the limitations of our mind. In our journey to explore the depth of our soul, we are never alone. While some may seek to stop us, many seek to guide us on our path. Authors, priests, gurus, therapist, friends; their consult may work or it may come unsolicited and irritate us with irrelevancy. However, one guide holds the wisdom to deliver accurate, remarkably authentic and pure advice. If we are committed to liberating our soul and opening the door for development and growth, we must pay heed to the guidance of mankind's oldest friend; the horse.
Horses have incredible powers to teach people about self imposed limitations, unproductive thought patterns and self destructive tendencies that prohibit them from reaching full potential. And yet the majority of people uses horses as a tool for self advancement in a more superficial nature. We seek success, monetary gain, approval, excitement and use horses to gain access to those things. In the process, the horses are gagged; after all, their voices would only hinder our quest for the things we think we need. Sometimes we silence them gently and with empathy. Other times our frustration steers us toward impatience and violence. No matter our approach, whenever we silence our horse, we take away our source for genuine, unbiased feedback; their freedom to respond to us the way they see fit.
Last week I finalized my certification with EAGALA, a world leader in Equine Assisted Psychotherapy. Their concept is simple, yet profoundly effective; bring horses and people together without restrains, allow the people and the horses to interact with each other and ask the people to reflect on their experience. While learning about the method, I participated in sessions with the horses. The experience was humbling. After years as a business consultant, I believed the reviews and coaching I received, had made me pretty aware of my thought patterns and proclivities. Yet the horses demonstrated my ignorance, and allowed me discover my authentic self. They showed me how my lingering perfectionism hinders me in finding peace. They demonstrated how I still struggle with conformity versus following my own heart. They uncovered how deep inside I am not satisfied with working all by myself and miss working in a team. They showed me how I am still trying to make my father, who passed away 10 years ago, happy by working as hard as I can so I'll never fail him. They showed me how much more I can do with gentleness instead of force. And they taught me much much more.
I want other people to experience this exceptional wisdom. I want people to not only uncover their own potential, but also the potential of the horse. The potential that is right there, in our barn, in our pasture, waiting for an opportunity to not be bridled, not be disciplined, not be steered around a dressage test. That potential that awaits us at the end of our lead rope and is unleashed the minute we untie the rope halter's knot.
We horses owners are lucky to have the most insightful, instinctual psychiatrists waiting for us to be ready to listen. Our horses are forever remaining in readiness for us to be become aware of how their peaceful wisdom can guide us back to ourselves, to our equilibrium, to quietude. My journey has begun. I can't wait to see where it leads me next.
Hours
M-T: 10am - 3pm
Telephone
+ 1 864.906.7576
monique@equineflow.com
"We cannot direct the wind, but we can adjust the sails." - Dolly Parton


Palomo I, Willemen L, Drakou E, Burkhard B, Crossman N, Bellamy C, Burkhard K, Campagne CS, Dangol A, Franke J, Kulczyk S, Le Clec'h S, Malak DA, Muñoz L, Narusevicius V, Ottoy S, Roelens J, Sing L, Thomas A, Van Meerbeek K, Verweij P (2018) . One Ecosystem 3: e20713.
Abstract
Ecosystem services (ES) mapping is becoming mainstream in many sustainability assessments, but its impact on real world decision-making is still limited. Robustness, end-user relevance and transparency have been identified as key attributes needed for effective ES mapping. However, these requirements are not always met due to multiple challenges, referred to here as bottlenecks, that scientists, practitioners, policy makers and users from other public and private sectors encounter along the mapping process.
New information
A selection of commonly encountered ES mapping bottlenecks that relate to seven themes: i) map-maker map-user interaction; ii) nomenclature and ontologies; iii) skills and background; iv) data and maps availability; v) methods-selection; vi) technical difficulties; and vii) over-simplification of mapping process/output. The authors synthesise the variety of solutions already applied by map-makers and map-users to mitigate or cope with these bottlenecks and discuss the emerging trade-offs amongst different solutions. Tackling the bottlenecks described here is a crucial first step towards more effective ES mapping, which can in turn ensure the adequate impact of ES mapping in decision-making.


Hawaii news now reports that the son of a country music singer Craig Morgan has died in a tragic boating accident. The 19-year-old boy, Jerry Greer, had been tubing with a friend when the incident occurred. The friend survived the accident, but Greer did not. Additional details surrounding the fatality have not been released.
With its idyllic climate and being surrounded by water, boating and other water sports are extremely popular in Hawaii. However, due to its popularity, boat operators need to use care to avoid accidents. This includes taking boating safety courses such as the one provided by the Department of Land and Natural Resources. According to the U.S. Coast Guard, roughly 7000 boating accidents are reported each year, and almost 1000 fatalities.
Additional safety measures include ensuring that you have life jackets, avoiding reckless or distracted boating, not boating under the influence, and staying out of hazardous water ways. Despite taking precautions, fatalities may still occur.
For more information, or if you or a loved one has been in a boating accident, please contact the experienced Hawaii personal injury lawyers at Bostwick & Peterson, LLP for an immediate consultation.


Selecta Biosciences and Asklepios BioPharmaceutical today announced the U.S. Food and Drug Administration (FDA) has granted Rare Pediatric Disease Designation to MMA-101 for the treatment of isolated methylmalonic acidemia (MMA) due to methylmalonyl-CoA mutase (MMUT) gene mutations. The FDA grants Rare Pediatric Disease Designation to incentivize development of new treatments for serious and life-threatening diseases that primarily affect children ages 18 years or younger with fewer than 200,000 people affected in the U.S. The Rare Pediatric Disease designation program allows for a sponsor who receives an approval for a product to potentially qualify for a voucher that can be redeemed to receive a priority review of a subsequent marketing application for a different product.
“This Rare Pediatric Disease designation from the FDA highlights the significant unmet medical need that Selecta and AskBio are seeking to address with MMA-101 for this rare metabolic disorder, When used with AAV gene therapy vectors, Selecta’s ImmTOR aims to inhibit the immune response to the AAV vector, potentially allowing re-dosing of gene therapies. Ongoing clinical programs will focus on evaluating product candidate performance in patients who may have been underdosed or those who may lose transgene expression over time. We’re honored to receive this recognition and look forward to advancing this program in hopes of helping young patients affected by MMA and their families.” Carsten Brunn, Ph.D., chief executive officer of Selecta Biosciences Said: “MMA is a serious and potentially life-threatening inherited metabolic disorder that presents in patients from newborns to adulthood, AskBio is committed to delivering transformative genetic medicines for rare diseases like this one, and the Rare Pediatric Disease designation helps us continue development of MMA-101.” Sheila Mikhail, J.D., CEO and co-founder of AskBio Said:
AskBio and Selecta expect to initiate a Phase 1 clinical trial of MMA-101 and ImmTOR for patients with MMA in 1H 2021.
About Methylmalonic Acidemia
Methylmalonic acidemia (MMA) is a rare monogenic disorder in which the body cannot break down certain proteins and fats. This metabolic disease may lead to hyperammonemia and is associated with long-term complications including feeding problems, intellectual disability, chronic kidney disease and inflammation of the pancreas. Symptoms of MMA usually appear in early infancy and vary from mild to life-threatening. Without treatment, this disorder can lead to coma and in some cases death.


當前土壤酸化加劇，而土壤酸化對作物養分積累和分配的影響仍不十分清楚。研究揭示土壤酸化對土壤養分有效性和植物吸收、積累、分配養分的影響，為酸化土壤治理尤其是養分高效利用提供依據。采用盆栽試驗，以酸性紅壤（pH 5.05）、櫻桃番茄(Lycopersivon esculentum Mill) 為試驗材料，采用檸檬酸-磷酸氫二鈉緩沖液和碳酸鈉-碳酸氫鈉緩沖液調節土壤pH，使土壤pH下調至4.0，5.0及上調至6.0和7.0，試驗共4個處理，每處理5個重復。結果表明，通過緩沖液調節，實測土壤pH為4.35、4.92、5.89、6.85，分別下調0.70、0.13及上調0.84和1.80個pH單位。土壤酸化顯著降低櫻桃番茄葉面積、生物量尤其是根系生物量，降低植株根冠比；土壤酸化嚴重抑制氮、磷、鉀、鎂、鐵在番茄根系的累積，而促進鐵、錳在莖稈和鈣、鎂在葉片的累積分配，使根系氮、磷、鉀、鈣、鎂、鐵積累量顯著降低，莖稈積累氮、鉀、鐵、錳較多，葉片積累磷、鈣、鎂較多，特別是植株各部位錳含量顯著提高。由此說明，根系是番茄植株受土壤酸化抑制最嚴重、最敏感的部位，并因此導致多數養分被根系吸收、遷移受阻而積累顯著下降。
Soil acidification is currently increasing, but how does soil acidification affect nutrients distribution and accumulation in plant is still not clear. Effects of soil acidification or pH on soil nutrient availability, nutrients concentration and accumulation, migration and distribution in plant were measured, with aim to utilize acidic soil and its nutrients efficiently. Pot experiment was conducted with acidic red soil (pH 5.05) and Cherry tomatoes (Lycopersivon esculentum Mill) as test materials, the soil pH was adjusted with citric acid-sodium hydrogen phosphate buffer and sodium carbonate-sodium bicarbonate buffer to adjust soil pH to 4.0,5.0,6.0 and 7.0. There were 4 treatments in total, with 5 replicates for each treatment. The result shows that measured soil pH were 4.35, 4.92, 5.89, 6.85, respectively, adjusted down by 0.70, 0.13 and increased by 0.84 and 1.80 pH. Soil acidification significantly reduced the leaf area and biomass of Cherry tomato, especially the root biomass,and root to shoot ratio. Soil acidification severely inhibited the accumulation of N, P, K, Mg and Fe in roots, promoted the accumulation and distribution of Fe and Mn in stem, and Ca and Mg in leaves. Significantly decreased N, P, K, Ca, Mg and Fe accumulations and its proportion to total in root, with more N, K, Fe and Mn accumulated in stems, more P, Ca and Mg accumulated in leaves, particularly raised all whole plant Mn concentrations significantly. It concluded that the root was the most severe and sensitive part of whole tomato plant inhibited by soil acidification, as a result, most nutrients were absorbed by the roots, migration were blocked, and accumulation was significantly reduced.


This study was initiated to investigate the economical impact of vaccination against tropical theileriosis in cattle in Cappadocia in Turkey. A total of 554 vaccinated and non-vaccinated animals were monitored for Theileria annulata infection using microscopic examination serology by measuring the antibody response of the animals by the indirect immunofluorescence antibody test (IFAT). The prevalence of T annulata infection, morbidity and mortality were significantly higher in unvaccinated than in vaccinated cattle, whereas the seropositivity was significantly lower in the unvaccinated group. Acute tropical theileriosis cases were diagnosed in 156 of 554 (27.61%) cattle, and 86 of 156 (56.21%) died from the disease. The total economic losses because of tropical theileriosis were estimated at US$598,133 for 2 years.


Title Date of Award
2017
First Advisor
Aaron Williams
Second Advisor
Jackson Liscombe
Third Advisor
Amanda Landi
Abstract
Recent years have seen a wide-spread adoption of conversational interfaces. Conversational agents, commonly referred to as chatbots, are programs that can exhibit human-like conversational behavior. They are taking over messaging platforms, redefining marketing and replacing human workers in customer support centers. However, there exists healthy skepticism on whether chatbots can deliver on what has been promised. This thesis aims to cover the main points of mismatch between the actual technology and its public perception by providing historical context for understanding modern chatbots. We consult Turing's ground-laying work to figure out why people were interested in talking to computers in the first place, highlight the role of dialogue systems in the general field of AI research and follow conversational agents on their journey for recognition, funding and purpose. We apply our findings by analyzing potential applications for chatbots within the Simon’s Rock campus and community.
Recommended Citation
Kotov, Maksim, "Chatting with Bots: A Quick Survey of Conversational Agents And Their Appropriate Applications" (2017).
Senior Theses. 1163. https://digitalcommons.bard.edu/sr-theses/1163
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Abstract
Purpose: This phase I study was conducted to determine the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) for the combination of bortezomib and alvocidib in patients with B-cell malignancies (multiple myeloma, indolent lymphoma, Waldenstrom macroglobulinemia, and mantle cell lymphoma). Experimental Design: Patients received bortezomib (intravenous push), followed by alvocidib (1-hour infusion), on days 1, 4, 8, and 11 of a 21-day treatment cycle. Patients experiencing responses or stable disease continued on treatment at the investigator's discretion. A standard 3+3 dose-escalation design was used to identify the MTD based on DLTs, and pharmacokinetic and pharmacodynamic studies were conducted. Results: A total of 44 patients were enrolled, with 39 patients assessed for response. The MTD was established as 1.3 mg/m
2 for bortezomib and 40 mg/m 2 for alvocidib. The most common hematologic toxicities included leukopenia, lymphopenia, neutropenia, and thrombocytopenia. The most common nonhematologic toxicities included diarrhea, fatigue, and sensory neuropathy. Three complete remissions (8%) and 10 partial remissions (26%) were observed for a total response rate of 33%. Pharmacokinetic findings with the current dosing regimen were consistent with the comparable literature and the hybrid dosing regimen. Pharmacodynamic study results did not correlate with clinical responses. Conclusions: The combination of bortezomib and alvocidib is tolerable, and an MTD has been established for this schedule. The regimen appears to be efficacious in patients with relapsed/refractory multiple myeloma or indolent non-Hodgkin lymphoma. As the nonhybrid regimen is less cumbersome than the previous hybrid dosing schedule regimen, the current schedule is recommended for successor studies. ASJC Scopus subject areas Oncology Cancer Research


Collateral Repair Project (CRP) is pleased to announce that we have been selected to receive an award of $25,000 from the U.S. Embassy in Jordan through the Julia Taft Refugee Fund.
The Fund, awarded by the U.S. Department of State’s Bureau of Population, Refugees and Migration, aims to address gaps in refugee protection and assistance through the implementation of sustainable programs. Julia Taft served as the Assistant Secretary of State for the Bureau of Population, Refugees, and Migration from 1997 to 2001.
With this award, CRP will expand its programs for women’s livelihoods over the coming year. CRP will offer beauty and salon skills training to 60 women. Additionally, 12 members of the Hope Workshop will receive special training in garment making. Over the coming year, we will provide a 36-hour module of business skills training for 120 women enrolled in both Hope Workshop and Beauty School. These programs help women from refugee communities to potentially create new income for their families.
Hope Workshop is a craft collective that allows women to express their creativity while also earning extra income for their families. Beauty School is a comprehensive course of salon skills. Held in the women-only section of our community center in Hashemi Shamali, both Hope Workshop and Beauty School are safe spaces for women to work and learn together.
We look forward to sharing success stories from this women’s livelihoods initiative at CRP in the coming months, and we express our sincere gratitude to the U.S. Department of State for this opportunity.
CRP, established in 2006, is a grassroots organization in Amman, Jordan providing needed assistance to refugees. CRP runs two community centers and is solely dependent on donor support. If you are interested in being a donor, please contact donors@collateralrepairproject.org.


Thursday, August 15, 2019
Abstract
In a two-year period, 1885-86, over 168 communities in America forcibly expelled Chinese residents from their midst. This essay, inspired by historian Beth Lew-Williams's book, THE CHINESE MUST GO, investigates the nineteenth-century purges of Chinese residents that occurred throughout the American west. I make three arguments. First, these acts of racial and political terror complicate our understanding of racial violence in America. Many of the actions were denounced, but they were also surprisingly effective in forcing business and political leaders to support the indefinite suspension of Chinese migration. Perpetrators faced almost no legal repercussions, and unlike for freed persons, racial violence didn't lead to significant legislation to help the Chinese. Judicial rulings were mixed: the recognition of birthright citizenship was a high point, but rulings that codified exclusion as a national policy and recycled theories of cultural incompatibility proved problematic. Second, this wave of domestic terror complicates our view of popular constitutionalism. A wide range of anti-Chinese mobilization — from aggressive boycotts to lynchings and beatings to purges accomplished without a single shot fired — were justified by perpetrators according to America's higher law tradition. It should trouble us that these methods were so successful. Third, moving in a normative direction, I urge a new way of talking about inequality where we don't merely stress reasons to oppose inequality but instead create a typology of different forms of inequality. This will allow us to better appreciate the clusters of harms that certain historical forms of inequality create, along with the clusters of reasons to oppose a particular type of inequality. For instance, the racial purges undertaken against the Chinese shared characteristics with other forms of inequality, especially lynching, detention, and the use of symbols or signage to convey a message of status inequality.
KJ
https://lawprofessors.typepad.com/immigration/2019/08/immigration-article-of-the-day-racial-purges-by-robert-l-tsai.html


Because of the many benefits of breast milk, working mothers may go to great lengths to ensure that their baby is fed breast milk when they are away. To offer adequate support to nursing moms and to ensure that the nutrients of the breast milk are protected, nannies must be knowledgeable about handling, storing, defrosting and serving breast milk.
According to La Leche League International, properly expressed milk can be stored at room temperature for up to 6 hours (4 being ideal) and it can be refrigerated for up to 8 days (72 hours being ideal). If it is not going to be used within that time frame, it should be poured into a clean, BPA free plastic nursing bag or glass or hard plastic container, sealed and placed into the freezer.
If the freezer is part of the refrigerator with a separate door, the milk should be used within 3 to 6 months. Milk stored in a separate deep freezer can be stored for six to twelve months. La Leche League International recommends placing the milk in the back of the freezer where the temperature is most consistent.
Frozen expressed milk should be thawed by placing it in the refrigerator overnight or by running it under cool water. Increase the temperature of the water to get the milk warm enough for feeding. Alternatively, containers of frozen breast milk can be thawed by placing them into a cup or bowl that has been filled with heated water. Thawed milk should be used within 24 hours and should not be refrozen.
La Leche League International states there is no research about whether freshly expressed milk left unfinished at room temperature should be discarded, or can be saved for a short time, perhaps up to one hour. Nannies should consult with the parents regarding the feeding of unfinished breast milk.
And while you can add freshly expressed breast milk to refrigerated or frozen milk expressed earlier in the same day, the Mayo Clinic advises that you should thoroughly cool the freshly expressed breast milk in the refrigerator or in a cooler with ice packs before adding it to previously chilled or frozen milk. Warm breast milk should also not be added to frozen breast milk as warm breast milk will cause the frozen breast milk to partially thaw.
Avoid using a microwave oven to warm expressed breast milk. Microwave heating may cause some hot spots in the milk that can burn the baby’s mouth. Microwave heating may also destroy some beneficial properties of the milk.


This review evaluates the potential of delayed cord-clamping for improving iron status and reducing anaemia in term infants and for increasing the risk of polycythaemia and hyperbilirubinaemia. We applied a strict search protocol to identify controlled trials of early vs late cord-clamping. Four trials from developing and four from industrialised countries were finally assessed. Two of the four studies from developing countries found a significant difference in infant haemoglobin levels at 2-3 months of age in favour of delayed cord-clamping. This difference was more marked when mothers were anaemic. Three of four studies from industrialised countries showed a significant difference in haematocrit levels in favour of delayed clamping. Although meta-analysis showed an increased risk for hyperbilirubinaemia of 12%, no studies reported the need to apply phototherapy or perform exchange transfusion. We conclude that delayed cord-clamping in term infants, especially those with anaemic mothers, increases haemoglobin concentration in infants at 2-3 months of age and reduces the risk of anaemia, without an associated increased risk of perinatal complications. In developing countries where fetal anaemia is common, the advantages of delayed cord-clamping might be especially beneficial.


Abstract
False claims are a key feature of confabulation, delusion, and anosognosia. In this paper we consider the role of motivational factors in such claims. We review motivational accounts of each symptom and consider the evidence adduced in support of these accounts. In our view the evidence is strongly suggestive of a role for motivational factors in each domain. Before concluding, we widen the focus by outlining a tentative general taxonomy of false claims, including false claims that occur in clinical settings as well as more garden-variety false claims, and incorporating both motivational and nonmotivational approaches to explaining such claims.
Keywords Anosognosia Confabulation Delusion Motivational processes


This is one of those arguments which we love to argue about. This duality, of yes versus no is very reflective of our culture and our love for binary oppositions. Last year, Prime Minister Joseph Muscat stated that work was being done with regards to building a tunnel between Malta and Gozo and it could be up and running within seven years (now six).
So what are the arguments in favour of a tunnel? For one,
travel time will be reduced, as people travelling from Malta to Gozo and vice versa will no longer need to board a ferry. This positively impacts those who travel with it on a regular basis for work, or else to study at the University of Malta. This will undoubtedly make things easier for Gozitans studying in Malta as there would be no need to rent an apartment, due to the hassle of travelling back to Gozo. Apart from this, the waiting time in traffic leading up to the ferry will be a thing of the past.
With a tunnel, Gozo becomes more
accessible to the Maltese and our tourists. This would undoubtedly increase activity in Gozo and contribute to its economy. Just think about the increase in occupancy rates for Gozitan restaurants and hotels. Even tourists who rent a car will have it easier to visit Malta’s sister island.
On the other hand, we have those who are strongly against the idea of adjoining Malta and Gozo via a tunnel. This side argues that making it more accessible will basically
transition Gozo into an extension of Malta, making it lose its identity. Gozo is a quiet place with a certain appeal, and those against the tunnel argue that it will become similar to Malta with its high-rise buildings and its hustle and bustle.
A tunnel will make the Gozo experience less attractive since the ferry is part of the trip. It will no longer be deemed as a short holiday for the Maltese, since it becomes accessible via a simple drive.
Gozo is undoubtedly facing change, an ageing population and the younger generation seeking pastures in Malta to satisfy their career ambitions.
Is the tunnel the right step forward in Gozo’s development?


By David Gauntlett
In Making is Connecting, David Gauntlett argues that via making issues, humans have interaction with the area and create connections with one another. either on-line and offline, we see that folks intend to make their mark at the international, and to make connections.
through the prior century, the creation of tradition turned ruled through specialist elite manufacturers. yet this present day, an enormous array of individuals are making and sharing their very own principles, movies, and different artistic fabric on-line, in addition to undertaking real-world crafts, artwork tasks, and hands-on experiences. Gauntlett argues that we're seeing a shift from a ‘sit-back-and-be-told tradition’ to a ‘making-and-doing culture’. individuals are rejecting conventional educating and tv, and making their very own studying and leisure as an alternative. Drawing on facts from psychology, politics, philosophy, and economics, he indicates how this shift is important and crucial for the happiness and survival of contemporary societies.