Inadequate Brain Glycogen Or Sleep Increases Spreading Depression Susceptibility Date2018 Author
Kılıç, Kıvılcım
Karataş, Hülya
Dönmez Demir, Buket
Eren Koçak, Emine
Gürsoy Özdemir, Yasemin
Can, Alp
Petit, Jean-Marie
Magistretti, Pierre J.
Dalkara, Turgay
xmlui.mirage2.itemSummaryView.MetaDataShow full item record Abstract
Objective: Glycogen in astrocyte processes contributes to maintenance of low extracellular glutamate and K+ concentrations around excitatory synapses. Sleep deprivation (SD), a common migraine trigger, induces transcriptional changes in astrocytes, reducing glycogen breakdown. We hypothesize that when glycogen utilization cannot match synaptic energy demand, extracellular K+ can rise to levels that activate neuronal pannexin-1 channels and downstream inflammatory pathway, which might be one of the mechanisms initiating migraine headaches. Methods: We suppressed glycogen breakdown by inhibiting glycogen phosphorylation with 1,4-dideoxy-1,4-imino-D-arabinitol (DAB) and by SD. Results: DAB caused neuronal pannexin-1 large pore opening and activation of the downstream inflammatory pathway as shown by procaspase-1 cleavage and HMGB1 release from neurons. Six-hour SD induced pannexin-1 mRNA. DAB and SD also lowered the cortical spreading depression (CSD) induction threshold, which was reversed by glucose or lactate supplement, suggesting that glycogen-derived energy substrates are needed to prevent CSD generation. Supporting this, knocking down the neuronal lactate transporter MCT2 with an antisense oligonucleotide or inhibiting glucose transport from vessels to astrocytes with intracerebroventricularly delivered phloretin reduced the CSD threshold. In vivo recordings with a K+-sensitive/selective fluoroprobe, Asante Potassium Green-4, revealed that DAB treatment or SD caused a significant rise in extracellular K+ during whisker stimulation, illustrating the critical role of glycogen in extracellular K+ clearance. Interpretation: Synaptic metabolic stress caused by insufficient glycogen-derived energy substrate supply can activate neuronal pannexin-1 channels as well as lower the CSD threshold. Therefore, conditions that limit energy supply to synapses (eg, SD) may predispose to migraine attacks, as suggested by genetic studies associating glucose or lactate transporter deficiency with migraine.


Much attention has been focused on the reaction of the magnetosphere to the solar wind during the recent extended solar minimum (2006–2010). Although this period was exceptionally quiet when categorized by some parameters (e.g., the number of sunspots) the solar wind still contained features which impacted the Earth's magnetosphere and caused geomagnetic disturbances. Recurrent corotating interaction regions (CIRs) and associated high-speed solar wind streams (HSSs) are typically associated with the declining phase of the solar cycle and were a regular feature of the solar wind during the most recent solar minimum. Here we compare and contrast strong and weak HSSs in the solar wind and their subsequent effect within the Earth's magnetosphere. We find significant differences between strong and weak HSS effects in the plasmasphere, in the ion and electron plasma sheets, and in the outer electron radiation belt. A density-temperature description of the outer radiation belt is shown to shed light on why the radiation belt flux is observed to return at a higher level after the arrival of strong HSSs than before strong HSSs and why the flux is observed to return at a lower level after the arrival of weak HSSs than before weak HSSs.


Over recent years, many South Africans have lost money after being taken in by advanced fee scams. An advanced fee scam is a hoax where you are promised access to a large sum of money as long as you pay a deposit first. Someone may trick you into paying an advanced fee to access a loan, an inheritance, an investment opportunity or money you are told you have won in a competition. Criminals may also ask you for help with transferring a large amount of money out of the country.
How common are advanced fee scams?
Over a five-year period, more than 5000 advanced fee scams were reported to the South African Reserve Bank. 22% of South Africans using e-banking services were taken in by scams in one year. Almost a third of these were advanced fee or 419 scams. A 419 scam is a type of advanced fee scam. In a 419 scam, someone is encouraged to send money to a stranger in exchange for a larger sum that never materialises.
Common scamming techniques
If you are asked to pay a fee to access money or some financial services, you may be being scammed. Once a scammer receives your payment, chances are you will never hear from them again – unless they ask for more cash. Scammers use a range of channels to seek out their victims. These include email, text, phone calls, WhatsApp and social media.
Fake loans, competitions and emails
Scammers may attempt to dupe you by promising you a large loan with no credit checks or an incredibly low interest rate. They may tell you that you’ve won a competition that you don’t remember entering or may inform you that someone you don’t know has left you an inheritance. Some scammers pretend to represent well-known companies. Famous lender Wonga’s brand image was used without permission by criminals several years ago as the front for an email and sms scheme of authentic-looking messages that look just like genuine correspondence. However, when you check the email address it may look strange or bogus.
Emails can seem very authentic
Another tell-tale sign is when a scammer refers to you as ‘sir’ or ‘madam’ rather than your name. However, some scammers will address you by your name. The correspondence you receive may also have spelling and grammatical errors, though this isn’t always the case. Some correspondence can seem very authentic indeed, which is why so many people fall for it.
What you need to do
It’s vital to ignore any correspondence you receive if you do suspect someone is trying to scam you. Don’t even respond to say you believe the message is bogus – inform the police immediately instead. If you do believe someone has targeted you with an advanced fee scam, contact the police by sending a message to [email protected]
Scamming during the pandemic
Criminals have been targeting unsuspecting members of the public via a number of methods during the global pandemic. In 2020, British banks revealed some of the most common techniques being used by criminals recently. Scammers have recently been sending out fake government emails offering Covid-19 support grants. However, links inside the emails may steal your personal and financial information. Emails offering Covid-19 relief fund access have also been circulating. Authentic-looking emails offering reductions in household bills have also been in circulation. Again, these are designed to obtain your personal and financial information.
New scams emerging
Many people have received fake emails telling them they have been in contact with someone who has contracted the virus. Once someone clicks a link inside the email, they may be taken to a fake website and asked for personal information. The website may also infect your computer, tablet or phone with malware. Fake adverts for products like hand sanitizer and face masks have also been found online. Once the victim sends their payment for these items, they don’t receive anything at all.
It’s essential to stay on top of the latest online scams to avoid being parted with your money. New scams are being launched all the time, so remain as vigilant as you possibly can.


posted on
Jan 18, 2018 by David McIntire
To date, many digital transformation initiatives have been primarily focused on customer-facing technologies. Changing customer preferences and the rise of new digitally native competitors have driven incumbent firms to see customer experience as a source of competitive advantage or as table stakes to maintain relevance. In NelsonHall’s recent survey of IT service buyers across 18 sectors, 61% identified both improved customer experience and increasing average revenues per customer as highly important business priorities.
These business priorities are primarily being addressed through digital initiatives, and 73% of buyers identified improving customer experience and customer service as a highly important benefit of digital.
But companies are also increasingly looking beyond the customer experience for digital initiatives. It should be no surprise that other business priorities identified as highly important by a significant portion of IT services buyers include increasing rate of automation (72%) and digitalizing their operations (67%).
These initiatives are increasingly looking at digital as an end-to-end operational transformation which enables the realization of other key benefits, including reducing operating costs and improving service fulfillment and turnaround time (each highly important to 73% of buyers).
While this has always been a focus area for sectors such as manufacturing and energy, it is also being prioritized increasingly in consumer-facing sectors. Companies are recognizing that the customer experience goes beyond the digital channel and spans the entire customer lifecycle, hence the importance placed on service fulfillment. Objectives being sought by consumer-facing sectors reflect this focus, expanding beyond customer experience to end-to-end digital transformation. Specific objectives cited by consumer-facing sectors include:
Increasing rate of automation in operations. This is being prioritized by more than 70% of organizations across retail, healthcare provider, travel & transport, retail & commercial banks, and media
Digitalizing operations, cited by ~78% of organizations across travel & transport, retail & commercial banks and media
Reducing service turn-around time, cited by 53% of organizations across healthcare provider, media, travel & transport, retail & commercial banking, and retail.
To achieve these defined objectives, consumer-facing organizations are targeting digital initiatives in non-customer-facing functions. Specific industries that have highlighted digitalization of end-to-end functions as a priority include:
Travel & transport: transforming supply chain and improving real-time asset tracking are the two most commonly identified digital initiatives by travel and transport companies. IoT/sensor-based applications is the most commonly cited digital technology and acts as the primary avenue for addressing these initiatives, a high priority area for nearly one in three organizations
Healthcare providers: while primary focus has been on patient care, including patient self-service, the second highest priority area is revenue cycle management, the end-to-end process from scheduling to payment, highlighted by 55% of organizations as being pursued currently. This primary internal focus is on the financial processes that support the end of the payment cycle
CPG: with 64% placing priority on the order management function, CPG companies, which sit at the intersection of manufacturing and consumers, are looking at optimizing the supply chain through broader integration and cloud-based applications. CPG companies also identified IoT/sensor-based applications as the most commonly implemented digital technology, with a primary focus on using IoT in manufacturing, procurement/supply chain, and warehouse management
Retail: improving and expanding integration across the supply chain is a key focus area for retail. Implementing IoT/sensor-based applications is the most common avenue for addressing this, a high priority for more than 40% of retail companies. IoT/sensor-based applications initiatives are primarily focused on addressing these supply chain improvements through improving warehouse management and logistics.
Consumer-facing industries have been undergoing significant digital disruption and are looking to transform interactions with their customers. While that continues, companies are increasingly focusing on how operations beyond the customer interface impact the customer experience. In 2018, this focus on improving end-to-end operations to improve customer service will continue apace.


The public health crisis has required advocates to adapt to many changes. This webinar showcases the successes and challenges of providing client-centered and trauma-informed services in the criminal justice system. The presenters further explore how practitioners have adapted the way they engage with victims/survivors, their CCR, and each other and how our ongoing partnerships in these systems have enabled professionals to continue to provide services for survivors.
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Don’t miss this relevant and practical offering with Sue Wehrspann on December 3rd!
Critical challenges are unrelenting during this global pandemic. Navigating change, organizational uncertainty, remote work, and pandemic fatigue can be stressful and difficult. Adjusting to these challenges is not easy, especially with the future unknown. These disruptions in routine often cause decreased productivity as a new balance is sought. It can be overwhelming. This session offers immediate solutions to real situations. Utilizing the latest neuroscience techniques, identify effective solutions for these unprecedented times.
Register here!
Join us this month for Emotional Intelligence Skills, Workplace Civility, Employment Law: Issue Spotting, Mitigating Unconscious Bias, Communication Tools: Interpersonal Mastery and more! Check out our 2021 January-June catalog! Get the best in leadership development, supervisory skills, legal and other timely topics. In addition, please peruse our coaching, mediation and investigation services Coming next week- Supervising a Virtual Workforce, Mitigating Unconscious Bias, Employment Law: Issue Spotting, Documentation Skills and Harassment Prevention. If what you need is not listed, please reach out to book a custom session at your location! lm@em-lm.com Join Jenny Douras for this informative, practical and relevant session!
Supervising can already be tough, but this shift to virtual environments can make the role even harder, particularly if it is new to you and your team. Learn how to effectively lead, motivate, guide, and engage your team in this new remote role. Set strategies for building and maintaining connection, fostering a culture of trust, and how to avoid mistakes that might be amplified in virtual settings. Identify best practices for you and your team as you continue to navigate this next normal for how work gets done.
Don’t miss Time Management with Doug Gertner, Resilience with Lisa Barbeau and Listening Skills with Kimberly Searfoorce! If you are looking for a companion offering to Nativagting Pandemic Fatigue, please join me for Resilience: Finding Happiness in Hard Times on November 11th! This session is designed for teams and individuals looking to build capacity in navigating this ongoing crisis.
Don’t miss this session with master facilitator Doug Gertner on Time Management and the art of mastering multiple priorities.
This seminar provides best practices and skills that emphasize priorities, organization, and staying on task. Learn to identify and attain long-term professional and personal goals. Discover the time wasters which are consuming your day and how they affect your performance. Better manage interruptions and the deluge of e-mails, voicemails, and other communications. Redesign your day so you can restore balance in your life and leave with the tools to make time for what is most important.
Oct 14, Nov 11 8:30-4:00 $245 Facilitator: Doug Gertner, Ph.D., Workplace Seminars & Solutions Don’t miss our virtual open enrollment offerings of Customer Relations, Lean Processes: Mindset & Tools, Creating a Kinder Workplace, Navigating Pandemic Fatigue. and Presentation Skills. No membership needed!
#organizationaleffectiveness; #kindness, #resilience


Trade Reform and the Evolution of Agglomeration in Vietnamese Manufacturing
It is well-documented that agglomeration contributes to productivity growth. However, concentrations of workers could also lead to increasing regional income disparities. Therefore, understanding the evolution of agglomeration is relevant for the formulation of industrial policy and inclusive growth. This study documents the extent, pattern, and determinants of agglomeration in Vietnamese manufacturing during 2002–2016, a period when substantial economic reform took place. Our major findings are three-fold. First, agglomeration, as measured by the Ellison–Glaeser index, has declined since the mid-2000s. Second, there exists significant sectoral heterogeneity in the level and trend of agglomeration. Third, we do not find a significant impact of trade and foreign direct investment on agglomeration per se. However, foreign direct investment in port districts does contribute to disagglomeration.


On August 17, 2019, the United Kingdom’s
Department for Environment, Food, and Rural Affairs (DEFRA) published a press release announcing a public consultation to help develop the country’s National Food Strategy. The UK announced that it is planning “for a radical shake-up of the UK’s food industry” and has launched “a call for evidence, giving everyone from consumers, farmers and food producers, to scientists and academics, an opportunity to shape how we produce, sell and consume food in the UK.” The feedback received will be used “to ensure the food industry is fit for the future, supports growth, enhances the environment and is resilient to the challenges posed by climate change.” Specifically, the strategy will review and build on existing agricultural, fishery, industry, childhood obesity, and environment bills.
In a note to academic scientists,
DEFRA highlighted that additional technical evidence will be asked for later in the consultation process. However, any new research that “strengthens or challenges the conclusions of previous reviews into specific topics” is welcome now, including not yet published information that could “contribute significantly to the debate.” The consultation is open online until October 25, 2019. Read more
DEFRA (August 17, 2019). “Public to have their say on the food system of the future.”
DEFRA (August 17, 2019). “National Food Strategy – Call for Evidence.”


The University of California, San Diego, commonly abbreviated as UCSD, is a public higher education institution, placed in the heart of the community of La Jolla, San Diego, United States. It was established in 1960 with donations from the city and the American aerospace corporation General Dynamics.
The institution is part of the state-wide University of California system, alongside other 9 semi-autonomous public institutions. UCSD is among the US Public Ivy colleges, whose objective is to provide students with the same quality of education as can be found in Ivy League’s private colleges.
As an important contributor in research activities, the university comprises of 6 undergraduate schools. It also features 3 graduate colleges, 2 medical centers and the famous Scripps Institution of Oceanography, which is the largest geological and marine science institute in the world.
A notable feature of the university is its numerous research institutes which receive considerable public funding. This investment has led to nearly 30,000 newly created jobs, notable profits generated from the sale of licensed technology and the launch of over 600 new companies operated by UCSD affiliates.
To maximize the level of collaboration and stimulate discussion, students and faculty members inhabit the same residential areas, part of the main university campus which is built over a 1500 acre plot of land. Students can also enjoy visiting some of UCSD’s recreational facilities, which include a eucalyptus forest, aquarium, and museum.
Student life at UCSD can be exciting for music lovers, who can attend November’s Hallabaloo music festival, which has featured acts such as Macklemore and Snoop Dogg in the past. Sports enthusiasts have the opportunity to support or even join some of the 23 competitive teams representing the university, in sports such as rugby, ice hockey and tennis.
UCSD has a network of more than 170,000 graduates and faculty members, including over 15 Nobel Laureates.


Comprehensive secure remote access solutions to adapt to new ways of working and minimize risk
The adoption of emerging technologies has become a differentiator, granting firms the competitive edge, particularly during the COVID-19 pandemic. The pandemic has impacted every aspect of the daily workflow for employees in Capital Markets firms. Trading desks are not the same. The work-from-home culture has accelerated the digital transformation across all functions in investment banks and buy-side firms. However, it has also left business units befuddled about the use of technologies. This change in the way of working brings new considerations and some inherent risks. The most obvious risk is cyber security—a poorly designed API can provide a window of opportunity for cybercriminals. Wipro secure remote access solutions perform quick assessments of infrastructure, requirements and expected maturity, while validating user / device posture to allow or deny, or restrict in the context of accessing applications or resources. This solution provides secure VPN access, software defined perimeter (SDP) services, secure VDI access, where these are used independently or in combinations to cater to customer specific needs.


Patriot Paws trains service dogs to provide comfort and care to veterans who have been wounded both physically and mentally. Each year, many vets come home from their tours of duty with both physical and emotional injuries. To help them become independent once again, Patriot Paws trains service dogs to help veterans readjust to everyday life. Founded less than 10 years ago, they have more than 30 dogs graduate from their two-year training program each year, and they are expanding quickly. Any veteran with a service-related disability may apply for a dog, and all dogs are given free of charge. After a veteran’s application for a dog is accepted, they are matched with a puppy even before the dog’s training begins.
Once a veteran receives his service dog, the veteran’s life changes forever. These dogs are life-long companions who accompany the veteran everywhere he go. Naturally intelligent and carefully trained, these dogs can perform tasks as “simple” as opening doors or as complex as bringing their owners a phone during an emergency. Beyond assisting their owners with daily chores, these dogs are trained to mitigate the symptoms of PTSD. Years of training combined with a high natural intelligence create a partner that provides the support, comfort, and protection our disabled veterans need.


NCASE Resource Library Featured Resources
This publication features some of the best resources, including webinars, briefs, and toolkits, available in the online NCASE Resource Library, developed for both practitioners and system builders.
These selected resources, curated by NCASE, offer ideas and information for OST system leaders to support recovery from COVID-19.
The NCASE Out-of-School Time Professional Development System-Building Toolkit was designed to assist states as they build professional development systems inclusive of school-age providers.
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This brief, based on a longer white paper, identifies and summarizes key findings in the existing literature on 12 protective and promotive factors relevant to afterschool.
This brief explores how programs that use a positive youth development approach can embed a racial equity perspective to effectively meet needs of youth of color. It suggests that programs think about who is offered program services, build staff capacity to recognize personal bias and structural inequalities, and insure leadership opportunities.
This issue brief provides recommendations for how to best support home-based child care providers during COVID-19, recognizing that this is an especially important part of the supply right now, and was already seeing instability and a decline in providers.
This PowerPoint presentation explores key principles for effective business management. It describes the concept of shared services. Some slides demonstrate the extensive resources of the ECE Shared Resources tool used by more than 20 states. It provides examples of strengthening business practices in New Hampshire and Pennsylvania.
This issue brief explores best practices for afterschool staff supervision of youth to ensure safety. It outlines the legal definition of neglect. It includes strategies for risk management including facility inspection, proper equipment, activity planning, first aid, and emergency preparedness.


Abstract
Objective: The Keep It Off trial evaluated the efficacy of a phone-based weight loss maintenance intervention among adults who had recently lost weight in Minnesota (2007-2010). Methods: 419 adults who had recently lost ≥ 10% of their body weight were randomized to the "Guided" or "Self-Directed" intervention. Guided participants received a 10 session workbook, 10 biweekly, eight monthly and six bimonthly phone coaching calls, bimonthly weight graphs and tailored letters based on self-reported weights. Self-Directed participants received the workbook and two calls. Primary outcomes are weight change and maintenance (regain of < 2.5% of baseline body weight). Results: Mixed model repeated-measures analysis examining weight change revealed a significant time by treatment group interaction (p < 0.0085). Guided participants regained significantly less weight than the Self-Directed participants at 12 and 24. months. The odds of 24. month maintenance were 1.37 (95% CI: 0.97-2.03) times greater in the Guided than in the Self-Directed group. When maintenance rates were compared across all follow-ups, there was a consistently higher maintenance rate for Guided participants (HR 1.31, 95% CI: 1.12-1.54). Conclusions: A sustained, supportive phone- and mail-based intervention promotes weight loss maintenance relative to a brief intervention for participants who have recently lost weight.
Keywords Behavioral intervention Maintenance Obesity Weight loss


Abstract
Purpose: Whether dyspnea, chest wall dynamic hyperinflation, and abnormalities of rib cage motion are interrelated phenomena has not been systematically evaluated in patients with chronic obstructive pulmonary disease (COPD). Our hypothesis that they are not interrelated was based on the following observations: (i) externally imposed expiratory flow limitation is associated with no rib cage distortion during strenuous incremental exercise, with indexes of hyperinflation not being correlated with dyspnea, and (ii) end-expiratory chest wall volume may either increase or decrease during exercise in patients with COPD, with those who hyperinflate being as breathless as those who do not. Methods: Sixteen patients breathed either room air or 50% supplemental O2 at 75% of peak exercise in randomized order. We evaluated the volume of chest wall (Vcw) and its compartments: the upper rib cage (Vrcp), lower rib cage (Vrca), and abdomen (Vab) using optoelectronic plethysmography; rib cage distortion was assessed by measuring the phase angle shift between Vrcp and Vrca. Results: Ten patients increased end-expiratory Vcw (Vcw,ee) on air. In seven hyperinflators and three non-hyperinflators, the lower rib cage paradoxed inward during inspiration with a phase angle of 63.4° ± 30.7° compared with a normal phase angle of 16.1° ± 2.3° recorded in patients without rib cage distortion. Dyspnea (by Borg scale) averaged 8.2 and 9 at the end of exercise on air in patients with and without rib cage distortion, respectively. At iso-time during exercise with oxygen, decreased dyspnea was associated with a decrease in ventilation regardless of whether patients distorted the rib cage, dynamically hyperinflated, or deflated the chest wall. Conclusions: Dyspnea, chest wall dynamic hyperinflation, and rib cage distortion are not interrelated phenomena.
Keywords Chest wall kinematics dynamic hyperinflation ergometry optoelectronic plethysmography oxygen supplementation ASJC Scopus subject areas Orthopedics and Sports Medicine Physical Therapy, Sports Therapy and Rehabilitation


Masdar’s Chief Financial Officer, Niall Hannigan, joined more than 1,000 global thought leaders, government officials and business leaders at the recent Milken Institute’s 2020 Middle East and Africa Summit in Abu Dhabi.
The two-day event, held from February 11-12, featured a range of speakers including Mariam Almheiri, UAE Minister of State for Food Security, Khaldoon al Mubarak, Chief Executive Officer of Mubadala Investment Company, Paul Ryan, a former US House of Representatives Speaker and Deepak Chopra, the Chief Executive Officer of the Chopra Institute. Hannigan joined a high-level panel at the summit, where participants discussed the significant growth of renewable energy in the Middle East, particularly in the UAE. During the panel, titled The New Energy Order: A Shift Toward Renewables, Hannigan said: “When Masdar was launched in 2006, renewables was a nascent industry and sustainability was nowhere near the top of the agenda. This has changed. Thankfully, the world is now taking climate change mitigation more seriously, and renewables is now part of the mainstream with an undeniable place in the energy mix offering cost competitive solutions when compared with conventional sources.


Medication errors in the hospital have been studied, quantified, and systematically evaluated for potential solutions. A notable exception is the perioperative setting, where medications given by anesthesiologists often bypass standard safety checks. This study is the largest prospective observational study of anesthesia-related medication events available to date. At least one medication error or adverse drug event occurred in nearly half of the 277 operations observed. Approximately 1 in 20 perioperative medication administrations resulted in a medication error or adverse drug event; 80% of these errors were deemed preventable. None of the errors resulted in death, but 2% were considered life-threatening. There were no differences in event rates among resident physicians, nurse anesthetists, and staff anesthesiologists. The study took place at an academic hospital with substantial local expertise in medication safety, where operating rooms already used a barcode-assisted syringe labeling system. An accompanying editorial suggests that medication error rates may therefore be even higher in other settings and community hospitals.


Aim: To measure epidermal growth factor receptor (HER1/EGFR) expression in a range of soft tissue sarcoma (STS) patient samples. Method: HER1/EGFR expression was examined by immunohistochemistry in archival tissues of 46 STS patients. Results: HER1/EGFR was positively expressed in 36/46 of STS samples distributed among different histological types. The levels of HER1/EGFR in STS tumour tissues in positive samples were higher compared to those in nearby normal tissues. Conclusion: HER1/EGFR is significantly expressed in soft tissue sarcomas, which is a finding reflected in other series. The significance of this finding for targeted therapy is as yet unknown.


Published on in Vaccine Update for Healthcare Providers
On Nov. 9, 2020, the pharmaceutical company, Pfizer, in collaboration with BioNTech SE, a German company, sent out a press release describing an interim analysis of their SARS-CoV-2 mRNA vaccine. Of the 43,538 participants enrolled in the trial, which were divided equally (1:1) in the vaccine and placebo groups, 38,955 had completed a second dose. After evaluating the first 94 illnesses in the trial, researchers found that the mRNA vaccine was 90% effective at preventing mild to moderate infection. This meant that roughly 86 people with COVID-19 were in the placebo group and eight were in the vaccine group. These observations were made at least seven days following the second dose, which meant that the vaccine was effective within 28 days of the first dose.
Pfizer pointed out that 30% of U.S. participants had racially and ethnically diverse backgrounds, but didn’t state the percent of participants that were greater than 65 years of age. The study plans to evaluate the effectiveness of the mRNA vaccine in preventing severe disease as well as effectiveness in those who had already been exposed to the virus.
Pfizer stated that it could now produce up to 50 million doses in 2020 and 1.3 billion doses in 2021.
Next Steps
Materials in this section are updated as new information and vaccines become available. The Vaccine Education Center staff regularly reviews materials for accuracy.
You should not consider the information in this site to be specific, professional medical advice for your personal health or for your family's personal health. You should not use it to replace any relationship with a physician or other qualified healthcare professional. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult your physician or, in serious cases, seek immediate assistance from emergency personnel.


Attend a session and schedule a meeting with James Pender, Lafayette Federal’s CFS 1 Financial Advisor, to receive a $25 LFCU Mastercard® Gift Card!2
Within just a few months, the COVID-19 pandemic has impacted not only our health, but also our finances, bringing uncertainty particularly for our retirement and investment accounts.
The increased volatility of the stock market, low interest rates, and stressed economy leave us financially vulnerable. This is true for many individuals investing for upcoming life events, and those who have experienced significant reductions in their savings.
Join James Pender, Lafayette Federal’s CFS Financial Advisor, for this webinar, where he will discuss the current environment and factors to consider for your financial plan.
More than ever, solid financial planning is essential in meeting your retirement goals.
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Research output: Contribution to journal › Article
Open
We report a genome-wide association scan in over 6,000 Latin Americans for features of scalp hair (shape, colour, greying, balding) and facial hair (beard thickness, monobrow, eyebrow thickness). We found 18 signals of association reaching genome-wide significance (P values 5 × 10(-8) to 3 × 10(-119)), including 10 novel associations. These include novel loci for scalp hair shape and balding, and the first reported loci for hair greying, monobrow, eyebrow and beard thickness. A newly identified locus influencing hair shape includes a Q30R substitution in the Protease Serine S1 family member 53 (PRSS53). We demonstrate that this enzyme is highly expressed in the hair follicle, especially the inner root sheath, and that the Q30R substitution affects enzyme processing and secretion. The genome regions associated with hair features are enriched for signals of selection, consistent with proposals regarding the evolution of human hair.
ID: 24375465


Despite being only the third-largest producer of wine, Spanish wines are some of the world's most popular. The country's varied climates also meant a wide range of wines, and these spirits reflect the unique cuisine and culture of each wine region. Spanish winemakers are also dedicated to their traditions, ensuring that every bottle remains consistent.
Another contributing factor to the popularity of Spanish wines is accessibility. As many Spanish wineries will pre-age their wines in oak barrels or bottles before selling them, consumers—especially first-timers—can sample the wines without the expensive storage investment. Spanish wines are also more moderately priced compared to their French and Italian counterparts.
Two key features of wine from Spain are the Denominación de Origen or Destination of Origin (DO), and aging. The DO tells consumers the geographical identity, or where the wine is made—from the type of grapes to how vines are maintained or harvested. This is usually shown on the bottle's label or cork.
Meanwhile, labels such as "Joven," "Crianza," "Reserva," or "Gran Reserva" indicate how long the Riejo region wines are aged. The meanings of these labels will depend on whether the wine is red or white and correspond to different levels of aging.
For a more in-depth look at Spanish wines, as well as a list of highly recommended red and white wines, continue to the infographic below.
Infographic Source:https://www.txanton.com.ph/post/spanish-wines-illustrated-guide


I've been practicing yoga "seriously" for almost two and a half years. I began yoga mostly because I needed to start exercising again after an intense job kept me from working out. I felt remarkably lazy. I thought, mistakenly, that yoga would be easy and I was hopeful that it would be bizarre enough to distract me from feeling as miserable as working out can often make you feel.
I was quite wrong and I'm so grateful for that.
Yoga has done some wonderful things for my body (the usual suspects of increased flexibility, strength, balance etc.) and wonderful things for my general approach to exercise. But, yoga definitely is not easy, and it's often unpleasant. I love that yoga continues to challenge and frustrate me while also being a necessary part of my sanity and well-being. I crave it,...


If you like cooking and working in the kitchen, you would be aware of the excitement that comes with using a newly bought kitchen appliance. In fact, the market is now flooded with several kinds of unique appliances you can make use of. These are also available in very cheap prices. We all have those toasters, mixers and sandwich makers in our kitchens. However, there are several unique kitchen supplies that you may not even know exist! Here are some of these convenient and unique appliances you must buy for your kitchen.
Frozen drink maker – A frozen drink is wonderful in the summer. However, nobody fancies making it. This is because the process involves crushing ice while separately making a drink. It involves mixing the two while making sure that the ice does not melt. You can now avoid this hassle by buying a frozen drink maker. It automatically shaves ice and mixes it with your drink to create the perfect concoction.
Yogurt maker – We all have, at one time or another, made yogurt at home. This is because it is not only cheap but also fresh compared to packed yogurt. However, it can often go wrong. This is why you should now buy a yogurt maker! Did you know such a kitchen appliance even existed? This is somewhat like a mixer that cooks milk until it reaches a thick consistency. You can control the cooking process and can turn the machine off when the yogurt has reached the thickness you prefer.
Drink chiller – It can often be frustrating when you want a cold drink but have to wait for it to chill in the freezer. Often, people simply resort to going over to the store to buy a chilled drink. However, with a beverage chiller in your kitchen, you do not have to do this. This is a kitchen appliance that spins a can of drink in ice and water. You can set a certain temperature and the machine will stop spinning when it reaches the specified temperature!
Some people might think that such kitchen supplies are a waste of money. However, if you think about it, you will realize that you almost always have to stop at the store to buy something that you cannot make at home. You can avoid such expenses by investing in some useful and unique kitchen supplies.


Beverage Manufacturers Exploring Ready-To-Drink Category In India Amid COVID-19
Monday, June 29th, 2020 | 677 Views
Amidst the COVID-19 pandemic, the beverage industry has witnessed a significant shift in the purchasing preferences of consumers in India, with steady rise and strong inclination towards ready-to-drink (RTD) beverages. This shift has encouraged the beverage manufacturers to re-evaluate their innovation strategies and explore options to diversify their portfolios, says GlobalData.
According to GlobalData COVID-19 survey, almost 40 percent Indian consumers bought more quantity of juices and squashes than before while 37 percent bought more dairy beverages. The survey also reveals that 60 percent of consumers prefer packaged drinks compared to freshly prepared alternatives. This implies that even though packaged RTD beverage concept is not new, the restrictions on movement due to nationwide lockdown has encouraged the consumers to stockpile RTD beverages.
“India has increasingly been looked upon as a promising market for the RTD beverage category over the past few years as the consumption continues to rise across the country. Panic buying and stockpiling during COVID-19 has put RTD beverages in demand more than ever and forced beverage brands to consider alternative ways to align with the consumers’ priorities,” said Shagun Sachdeva, Consumer insights analyst at GlobalData.
Leading Indian beverages manufacturers such as Nestlé, PepsiCo and Coca-Cola are forecast to be the worst hit due to the pandemic. All these players registered significant volume drops due to the shutdowns of malls, restaurants and cinemas amid the lockdown. In April 2020, Coca-Cola reported a five percent decline in unit case volume in bottling operations in India, due to the lockdown enforced from 23 March 2020. Therefore, companies have been under pressure to undertake measures for streamlining production and mitigate risk of losing consumers to competitors.
Sachdeva adds: “With multiple options of beverages, consumers have become more experimental and less loyal to brands, thereby compelling the manufacturers to continuously innovate to retain their consumers along with keeping affordability factor in mind.”
The recent RTD beverage launches will not only addresses consumers’ health concerns but also seems to capture the spirit of the times with the emotional value. For instance, beverage manufacturers are developing more personalised products targeting the distinct needs of specific consumer cohorts. However, brands need to strategise on how to retain their appeal post-COVID-19.
Sachdeva concludes: “While it is difficult to anticipate the full extent of the changes COVID-19 will trigger, beverage companies are trying their best to keep the category alive and vibrant while coping with the pandemic challenges.”
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The vent stack in a residential building is an imperative part of the drainage system, and when it breaks down, the results can be disastrous. Without the vent stack maintaining the atmospheric pressure in the pipes, residents can experience leaking sewage and rainwater in their apartments and outside of the building, resulting in stagnant pooling water and hazardous conditions. If you own or reside in a residential building, proper maintenance to the vent stack can mean the difference between water damage and unhealthy conditions and enjoying a dry, clean environment.
NuFlow Oklahoma offers an innovative way to ensure that the vent stack in your building stays in excellent shape. We can help you avoid a pricey bill for property damage from a faulty stack. The best part is, as a non-invasive repair method, vent stack lining is a contemporary way to replace existing stacks without the hassle of digging up flooring, breaking through infrastructure, or disturbing landscaping. You’ll save money on property remediation costs and labor, thanks to this simple, modern repair method.
During vent stack lining, one of our licensed technicians will insert a high-definition camera into the stack to examine the conditions inside through an existing access point. This access point will be used to perform the entire process, eliminating the need for excessive damage to the building. If necessary, the stack will be flushed or cleaned to remove debris. A fiberglass liner is then inserted with a winch cable through the vent pipes. The end is secured with nylon straps and the liner is inflated and cured with UV light until it hardens. After the liner has hardened into place, the installation equipment is removed. The new vent stack will be up and running and ready to service the building.
When it’s time to inspect or repair your vent stack, you can trust NuFlow Oklahoma. As specialists in non-invasive pipe lining services, we have the experience, expertise, and equipment to perform lasting vent stack repairs at your property.


The range of the California Halibut, Paralichthys californicus, spans three biogeographic provinces along the coastline of Alto (United States) and Baja (Mexico) California. To assess population genetic structure of the California Halibut, we analyzed mitochondrial cytochrome b sequences from 375 individuals across a large portion of its native range. Nucleotide diversity was consistently low among sampling sites (π = 0.0026 ± 0.0017), while haplotype diversity was consistently high (h = 0.77 ± 0.024). We found that California Halibut were genetically homogeneous across sampled sites with an overall Φst = 0.0030 (p = 0.22). We saw no evidence of genetic discontinuities at two previously recognized marine phylogeographic breaks in the Los Angeles region or across the California Transition Zone at Point Conception. We conclude that California Halibut are genetically homogeneous and experience substantial gene flow, at least over evolutionary time scales.


A Look Into Consumer Defensive Sector Value Stocks What Defines a Value Stock?
A value stock is traditionally defined in terms of how investors in the marketplace are valuing that company’s future growth prospects. Low P/E multiples are good base indicators that the company is undervalued and can most likely be labelled as a value stock.
Below is a list of notable value stocks in the consumer defensive sector: Big Lots(NYSE: BIG) - P/E: 5.66 Ingles Markets(NASDAQ: IMKTA) - P/E: 8.08 Adtalem Glb Education(NYSE: ATGE) - P/E: 8.18 Mannatech(NASDAQ: MTEX) - P/E: 7.77 Pingtan Marine Enterprise(NASDAQ: PME) - P/E: 5.02
Most recently, Big Lots reported earnings per share at 1.26, whereas in Q4 earnings per share sat at 2.39. Its most recent dividend yield is at 3.08%, which has decreased by 2.19% from 5.27% in the previous quarter.
Ingles Markets has reported Q2 earnings per share at 1.99, which has increased by 128.74% compared to Q1, which was 0.87. Its most recent dividend yield is at 1.64%, which has decreased by 0.39% from 2.03% in the previous quarter.
This quarter, Adtalem Glb Education experienced an increase in earnings per share, which was 0.57 in Q2 and is now 0.81. Adtalem Glb Education does not have a dividend yield, which investors should be aware of when considering holding onto such a stock.
Mannatech’s earnings per share for Q1 sits at 1.15, whereas in Q4, they were at 0.87. The company’s most recent dividend yield sits at 3.39%, which has increased by 0.29% from 3.1% last quarter.
Most recently, Pingtan Marine Enterprise reported earnings per share at 0.1, whereas in Q4 earnings per share sat at -0.01. Its most recent dividend yield is at 1.47%, which has increased by 0.49% from 0.98% in the previous quarter.
The Significance: A value stock may need some time to rebound from its undervalued position. The risk of investing in a value stock is that this emergence may never materialize. © 2020 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.


Efforts in the U.S. to create a dedicated pathway for fintechs to acquire bank charters made little progress, until recently.
For years, some fintechs had been exploring alternatives that now seem more viable: seeking industrial loan company (ILC) charters or joining so-called sandboxes established by state regulators — a path once considered the only option for fintechs while a federal bank charter remained in limbo. However, several recent regulatory changes will create a more open, albeit bumpy, road for fintechs to become banks.
In March, the Federal Deposit Insurance Corp. made two key moves. It first proposed a new standard for ILC charter applicants that would require parent companies to provide liquidity and capital support for their ILC subsidiaries, as well as meet new recordkeeping and reporting standards. A day later, the FDIC approved the ILC charter applications for small-business payments giant Square and Nelnet, a student loan servicer. The action made Square the first fintech to receive federal deposit-insurance approval to form a bank.
If the FDIC’s proposal goes into effect, fintechs could be well positioned to acquire ILC charters so long as they meet the new reporting requirements; provide a rescue plan for injecting liquidity if needed; and gain support from state regulators.
Keep reading on American Banker.


The Q1 reporting period in China reflected the immediate devastation of mobile commerce before lockdowns turned the tides.
The Q1 2020 figures for China’s third-party mobile payment market, published by independent market research firm, iResearch have revealed some expected trends.
With a dominant share of 55.4%, Alipay remains in the lead as China’s largest third-party mobile payment company, followed by Tenpay (which is Tencent’s WeChat Pay + QQ Wallet) with 38.8%.
Alipay has continued to increase its mobile payment market share for four consecutive quarters since Q1 2019.
Amid the COVID-19 outbreak during the reporting period, China saw a decrease in third-party mobile payment transactions for the first time, at RMB53.2 trillion—a 4% drop compared to the same period in 2019.
With the release of the Q1 report, iResearch pointed out that future growth opportunities in China lie with the third-party payment providers’ capability to offer business clients integrated “payment + technology” solutions, instead of competing just on payment volume.
Payment is not the end game
Earlier in March, Alipay had announced a three-year plan to support the digital transformation of 40 million service providers in China. It committed to provide a platform for comprehensive digital daily life services, and a go-to app for consumers to find service providers to help meet their daily needs.
When asked about its view on the mobile payment market share, Alipay’s spokesperson emphasized that “payment is not the end game, but the beginning of a wide range of services that enrich daily life. We are dedicated to supporting the digital transformation of the services industry by leveraging our technologies, instead of just focusing on payment market share.”
This official sentiment reflects the company’s business model that aims not only to provide payment solutions but also, to provide a comprehensive digital suite of technologies, including payment, to service providers.


Fraudsters ready for 2014 festive season
With credit card fraud and Internet scams an ever-present threat across the globe, South African consumers need to be particularly cautious during the run-up to the 2014 festive season.
According to Richard Keymer, head of pre-sales at SecureData Africa, phishing remains the most common way in which South Africans inadvertently disclose their personal information online.
The victims get caught by fraudsters who pose as a financial institution and circulate an e-mail that appears to be from a legitimate site such as a user's bank, but, in fact, it comes from an external party masquerading as the financial organisation, he says.
According to an article by Webber Wentzel, just under 100 SIM swap fraud cases were reported in 2011, and this increased to just under 1 000 cases in 2013, reflecting a 900% growth.
Keymer notes SIM swap fraud attempts to undermine two-factor authentication methods. He argues that while receiving a one-time-PIN SMS is not the most secure second-factor authentication, it reduces instances of this type of fraud, though it has gained notoriety due to the fact that it is cheap and easily deployed to a large client base.
The banks notify the user when a beneficiary is being created on their account and require this PIN before proceeding. In the event that the SIM swap has been performed, the hacker would now receive this notification and PIN to their device, he explains.
The use of this as a fraud method in South African banks hit the media in the middle of last year, says Keymer.
Keymer notes the banks and the cellular networks have taken measures to prevent and inform users of these attacks. For example, he says, users will now receive a notification of intent to perform a SIM swap to the existing SIM before this is completed.
"South African banks and mobile operators use SMS as an effective communication tool, and notification would often be sent to inform the user," he notes. He advises if any e-mail or SMS is received, it is recommended that users contact the service provider immediately.
Keymer believes users should initiate contact with the service provider and query the alert. He points out all too often users get contacted and dismiss the alert based on contact from the fraudster notifying the user that there was a technical issue and it has now been resolved.
"It is worth mentioning this SIM fraud is only a component of the hack, and a username and password would still need to be compromised, and this is typically done through phishing, but could be done through malware and network hacking," he concludes.


Comment Opportunity: Speak Out to Preserve Access to SNAP, School Meals USDA is currently requesting comments on a proposed rule that would undermine SNAP’s broad-based categorical eligibility, adding new barriers to access SNAP benefits and eliminating direct certification of children in school meals programs. Currently, categorical eligibility allows more families to readily access nutrition assistance by simplifying SNAP's asset and income tests. Should this proposed rule be implemented, nearly 3 million SNAP participants and approximately 500,000 children receiving school meals will be ineligible to continue receiving fundamental nutrition assistance.
The proposed rule is open for public comment until September 23. NWA has released template comments to support WIC staff and agencies in responding to the proposed rule. Should you have any additional questions, please reach out to Brian Dittmeier, Senior Public Policy Counsel, at bdittmeier@nwica.org.
Four Lawsuits Challenge Final Public Charge Rule Last week, the Department of Homeland Security announced the final rule on public charge.The final rule expands limitations on legal immigrants, penalizing individuals who are seeking legal status if they accessed SNAP, Medicaid, or housing subsidies. WIC is not included in the final rule.
Last Tuesday, San Francisco and Santa Clara Counties filed the first of four legal challenges against the rule. Over the course of the week, additional lawsuits were brought by eighteen State Attorneys General and advocate groups, including healthcare providers. The states challenging this policy change include: Washington State, California, Colorado, Delaware, Illinois, Maine, Maryland, Massachusetts, Michigan, Minnesota, Nevada, New Jersey, New Mexico, Oregon, Pennsylvania, Rhode Island, Virginia, and the District of Columbia.
The final public charge rule is due to go into effect on October 15. This litigation could delay implementation of the policy change, if the courts grant a temporary stay.
NWA has created resources to assist clinics with counseling concerned participants. The updated resources included NWA’s FAQ documents on public charge, with translations in both Spanish and Chinese. Lastly, you can also view NWA’s press release regarding the final rule here.
The August Recess is a Perfect Time to Connect with your Member of Congress Both the House and the Senate are on recess for the entire month of August, making this a perfect time to connect with your member of Congress. As they meet with key constituents in their communities, legislative staffers are considering key WIC priorities, including 2020 appropriations funding levels and pending proposals for Child Nutrition Reauthorization.
Last week, the South Nutrition Center WIC Program, hosted Congressman Jim Cooper (D-TN) at their WIC clinic. In celebration of National Breastfeeding Month, the Congressman accepted an invitation to visit the WIC clinic to see first-hand how the program helps and supports Davidson County moms with breastfeeding. He received a tour of the facility, and learned about the Breastfeeding Peer Counselor Program.
During this recess, NWA encourages you to connect with your member of Congress and set up clinic visits. Setting up these visits allows your legislator or staffer to see the excellent work you’re doing every day, as well as increase their knowledge of this vital public health nutrition program. If you are unsure of how to set up a WIC clinic visit, please refer to NWA’s advocacy toolkit section on contacting your elected official, or reach out to Kirsten Kelley, State Public Policy Associate, at kkelley@nwica.org.
Legislators Seek to Protect Children from ICE Detention Senator Jeff Merkley (D-OR) and Rep. Grace Meng (D-NY) introduced the Stop Cruelty to Migrant Children Act, a new bill that would enact new requirements for the health, safety, and well-being of children and families that are in federal immigration detention. Senator Merkley is a recipient of the NWA Leadership Award for his steadfast commitment to WIC and his work to promote breastfeeding. NWA has endorsed this new bill, which would ensure that any infant or child in federal custody is fed three meals a day that align with the WIC and school meals nutrition standards.
The bill more broadly limits the detention of children for extended periods of time, consistent with the Flores precedent that encourages quick release of children into family or community settings.
NWA has spoken out on the needs of migrant infants and children. Another example of the current system's flaws was exposed earlier this month, when a breastfeeding mother was detained during an ICE raid at a food processing plant in Mississippi. After eleven years in the United States, she has been separated from her three children - including a four-month-old infant - for 12 days at a facility nearly 200 miles away. She has stated that she is in pain from being separated from her children, as well as not being able to pump. NWA will continue to monitor the detention of migrant women and children and advocate for more humane conditions that adequately address their nutrition and health needs.


Not all volcanoes are quickly explosive. Some spew steady rivers of gloppy, gradual-moving lava for millennia on close, like people in the Hawaiian or Galápagos islands.These are what volcanologist Michael Stock...
COVID-19 triggers a strong immune reaction in most people today. Still various current scientific studies noticed that the quantities of antibodies in individuals recovering from the virus surface to drop...
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Tips On How To Stimulate Your Dog's Appetite
In Dog Food | Written by Emily White
A pet dog losing its appetite is not an uncommon thing. However, as common as the occurrence may be, it should be dealt with immediately. A dog should eat at least twice a day.
Be sure to watch the quantity your dog consumes on a daily basis. Experts and veterinarians always advice dog owners to learn their dog’s behavior. This way, you can quickly spot when something is wrong.


Despite weaknesses, the new sub-compact SUV has the potential to bring the Japanese car maker back into the ...
India’s homegrown Self-drive mobility start-up Revv today announced its initiative to offer cars at zero fee to assist healthcare workers amid the coronavirus outbreak.
According to the official release, in times when healthcare workers continue to fight the pandemic, the unavailability of public transport options has made their daily commute to hospitals more difficult. Revv believes that with this initiative the problem of commuting could be solved.
This service is available in 5 metropolis - Delhi, Bengaluru, Mumbai, Chennai, and Pune. In each of these cities, Revv promises to make its current fleet of cars available, free of charge, to healthcare workers currently engaged in active duty at a hospital, upon submission of relevant ID proof. Revv will mobilize 1000+ cars to start with and include more as the need escalates.
In each of the 5 cities where Revv is providing this service, healthcare workers can reach out to Revv to place a booking. Revv will also add the service to its website and apps soon. After placing the booking, the healthcare worker can pick up the car from Revv’s delivery centers, and use it entirely free of charge. The Delhi-based company will require the user to share a copy of his proof of work (such as the hospital ID card) at the time of placing the booking. Revv mentioned that all the cars would be sanitized before handover.
According to Revv’s Co-founders, healthcare workers battling the COVID-19 crisis at the frontline are the true heroes, and several of them are facing challenges with their commute to hospitals because of no availability of public transport. This is the least that Revv can do for them.
The cofounders, in a joint statement, said: “We’re inviting partners across these cities to help us accelerate this. For example, In Bengaluru, we are partnering with a 12,000 strong citizen volunteer group, to facilitate the distribution of these cars to healthcare workers that they are engaged with.”


Yearn Finance is currently the fastest-growing decentralized finance (DeFi) protocol in the crypto space.
This growth reflects on the project’s governance token (YFI) that rallied from about $1,000 a couple of months ago to highs of nearly $40K set yesterday.
The project personifies the desire of DeFi enthusiasts to cannibalize Centralized Finance (CeFi) and make financial services accessible to everyone.
Yearn Finance was designed by its founder Andre Cronje to give investors access to the most profitable yield farming opportunities.
The project has quickly gained momentum amongst crypto traders, mainly due to its automated liquidity mining and yield farming strategies.
Since the project became a hit with investors, its native token YFI has surged massively in value; it outperformed BTC as it hit $16K on Aug 20.
Over the past week, YFI leapt even higher, eventually reaching over $30,324 on Aug 29. The very next day, YFI posted an all-time high (ATH) price of $39K before correcting lower.
At the time of this article’s writing, YFI/USDT hovers around $33,954 with the total value locked (TVL) within the Yearn Finance pools now approaching the $1 billion mark.
YFIUSDT Price Chart | Source Tradingview
What’s Behind YFI’s Explosive Growth?
Yearn Finance has primarily gained popularity due to its ability to aggregate yields from other lending protocols. YFI holders can also use their tokens to vote on proposals for the project’s improvements.
Yearn Finance creator Andre Cronje initially designed the platform to work as a yield automation tool, but the protocol has quickly evolved into a stack of various DeFi products.
It offers lucrative features, such as automated liquidity mining strategies and the trading of stablecoins, including DAI with up to 1,000x leverage.
On Aug 28, top leading DeFi platform Aave announced the listing of YFI onto its protocol. The listing provided YFI with some positive price pressure that led to the recent price surge over the weekend.
YFi holders can now earn further yields on their YFI and access simple Aave loan liquidations. What’s more, the protocol recently revealed plans to launch a new form of permissionless insurance dubbed “yinsure.finance.”
The imminent release of yInsure caused YFI to rally by approximately 40% in 24 hours, outperforming most other token assets in the market.
How Far Can Yearn Finance Go?
YFI managed to hit an ATH price of $39K this past week after posting two previous peak values of $27K and $32,843 on the same day.
The impressive momentum has gained the attention of many prominent personalities in the crypto and DeFi sectors, with some suggesting that YFI’s rally is just getting started.
For instance, the CEO of Bitmex, Arthur Hayes, tweeted on Aug 30 that YFI can climb as high as $100K.
Despite the current hype surrounding YFI, traders should deploy suitable stop losses and low leverage when trading derivatives platforms.
These precautionary steps could help mitigate heavy capital losses in case YFI corrects hard in the near term.


Uncover Bipolar Disorder through a visual journey.
For the last three years, Dr. Christophe Lambert PhD and an expansive team of researchers have worked on a comprehensive and profound study into Bipolar Disorder. Now, combining a wealth of research, the latest analytics, and personal insights, this graphic novel examines their findings.
Using big data analysis of over a million medical claims, as well as the personal lived experiences of those diagnosed with Bipolar, this book investigates the impact of Bipolar Disorder on the lives of those suffering with it, the mania and depression which are often initially misdiagnosed, and the treatment protocols which have failed to find a uniform, one-size-fits-all approach.
This book is a must-read for anyone looking to understand more about Bipolar Disorder and the millions of people who live with it every day.
You can order it on Amazon at this link or download it it for free below.


Abstract
Metal dependent protein-based assemblies derived from the cartilage oligomeric matrix protein (C) coiled-coil domain (His
6-C) and two variants with mutation at position 40 (His 6-T40A) and 44 (His 6-L44A) are explored. All proteins have an N-terminal hexahistidine tag (His 6) that interacts with divalent metal ions Zn(II) and Ni(II). Binding to Zn(II) confers enhanced helical structure and stability, while Ni(II) promotes aggregation. Surprisingly, His 6-L44A undergoes a conformational switch from unstructured to α-helix in the presence of Zn(II). Both His 6-C and His 6-T40A further assemble into discrete nanofibers that appear to be stabilized by Zn(II) in which the fiber formation is dictated by the α-helical content. Because Ni(II) promotes aggregation, the proteins visibly cluster, forming large fiber mats in the case of His 6-C and His 6-T40A or aggregated structures as observed for His 6-L44A. Due to the unique pentameric assembly of the proteins, recognition of a small molecule within the pore is assessed using curcumin as the guest molecule. In the presence of Zn(II), there is enhanced binding to curcumin, while the addition of Ni(II) causes a loss in binding. It is shown that metal binding serves as a trigger to control the conformation of the proteins, affecting the nanoscopic fibrous assemblies and small molecule recognition abilities. Keywords coiled-coils fibers metals self-assembly small molecule recognition stimuli-responsive materials ASJC Scopus subject areas Chemistry(all) Materials Science(all) Condensed Matter Physics


The architectural facade addresses and enhances the space of the city, while displaying, or dissembling, interior arrangements. In this book, Charles Burroughs tracks the emergence of the facade in late medieval Florence and then follows the sharply diverging reactions of Renaissance architects to new demands and possibilities for representation in both residential and governmental contexts. Understanding the facade as an assemblage of elements of diverse character and origin, Burroughs explores the wide range of formal solutions available to architects and patrons. In the absence of explicit reflection on the facade in Renaissance architectural discourse, Burroughs notes the theoretical implications of certain celebrated designs, implying mediation on the nature of architecture itself and the society it serves and represents, as well as on the relationship between nature and culture.


If you're someone who suffers from anxiety, you know how pervasive, distracting, and frustrating overthinking things can be. Even if you are able to manage your anxiety, it's common for thoughts to come creeping back in, which is why it can be useful to know somehacks tostop yourself from overthinking. Discovering good habits and mental tricks is key when it comes to managing anxiety and intrusive thoughts, especially when you find yourself ruminating frequently.
"We all have a tendency to overthink things, especially when it comes to decision making," psychotherapist Kelley Kitley tells Bustle. "We want to make sure we make the 'right' decision and therefore play out 10 different scenarios. However, this can lead to anxiety, and ultimately, indecision. When people engage in overthinking, they may suffer from insomnia because they are laying in bed at night overthinking. ... They may struggle to connect in relationships because they are distracted and not present due to overthinking."
While you may have a handle on other symptoms of anxiety, if you've found that overthinking has taken over you brain and is impacting your life, try out some of these seven hacks that experts recommend to prevent you from being in your head too much.


The hard work of good data analysis is often surrounded by an array of glamourless, mundane, and underestimated processing steps.
These requisite steps can include retrieving, validating, cleansing, blending, enriching data from disparate and distant data sources, and then visualizing, delivering and archiving the analysis results.
A good data integration strategy is key to building a strong analytics function in your organization.
Check out our webinar where we describe how to effectively nestle your analytics in a data integration workflow that protects it from changes in data size, structure, quality, format and location. See how truly understanding your source data and its integration journey will transform your results.
Kevin Scott is CloverDX's Senior Consultant, where he works with customers on complex data consultancy projects with, helping them to succeed on their journey and overcome data challenges.


Public Confidence and Debt Management: A Model and A Case Study of Italy
High debt countries may face the risk of self-fulfilling debt crises. If the public expects that in the future the government will be unable to roll over the maturing debt, they may refuse to buy debt today and choose to hold foreign assets. This lack of confidence may then be self-fulfilling. This paper argues that under certain conditions, the occurrence of a confidence crisis is more likely if the average maturity of the debt is short. In the contrary, a long and evenly distributed maturity structure may reduce such a risk. We consider the recent Italian experience from this perspective. In particular we ask whether recent developments in the market for government debt showy signs of unstable public confidence, and of a risk premium.


One of the key components of an effective home energy audit is infrared thermography. Infrared thermography (or infrared imaging, infrared diagnostics, a rose by any other name...) consists of a thorough visual inspection of a home, including the basement, attic, and all the nooks and crannies, with an infrared camera or another infrared assessment device. It essentially takes the guess-work out of pinpointing the drafts and the leaky spots within a home — registering, as it will, the exact temperature of various spots within the home, and, depending on the device used, providing you, the homeowner, with a precise visual representation of the imperfections in your home's thermal envelope.


Like many other forms of cancer, pancreatic cancer can spread locally to blood vessels and surrounding organs such as the stomach. Cancer cells can also break away to affect more distant sites, such as the liver, lungs, and lymph nodes. Pancreatic cancer is one of the most challenging diseases physicians face today because it is difficult to diagnose early and responds poorly to treatment. Despite the fact that these secondary tumors affect sites other than the pancreas, they are still considered and treated as pancreatic cancer.
Continue Learning about Pancreatic Cancer Treatment
Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.


In my 6 ½ years working for
Hawaii Home + Remodeling, hundreds of homeowners, builders, designers, architects and suppliers have shared their expertise and creativity with me.
I’ve learned what it takes to become a homeowner in Hawaii and bought my first place. I’ve seen how to make the most of a small space and purchased size-appropriate furniture for my condo. I invested in pieces that are sustainably sourced and crafted, feeling confident in the quality. I plan to upgrade my flooring to luxury vinyl tile for its durability, and daydream of one day updating my kitchen cabinets. And if I ever move into a home with a yard, I know where to turn for landscape design and hopefully even a pool. All of this was inspired by the people I’ve connected with through my work at the magazine.
This has truly been my dream job come true. As I turn the page to the next chapter of my career, I want to thank everyone who has shared this journey with me: my talented colleagues, driven builders, creative designers, innovative architects, knowledgeable suppliers and passionate homeowners. It has truly been a pleasure working alongside each of you.
A home is so much more than a place to live. It is where we grow, as individuals and as families, and it should
feel like home. I hope you continue to find incredible inspiration and ideas in the magazine, as I have over the years. It’s been an honor to bring you stories of Hawaii home upgrades, renovations and new builds. I look forward to reading Hawaii Home + Remodeling for years to come, and I hope you will too. Maybe one day, our homes will be featured in the magazine.
Best wishes always,
Stephanie Silverstein, Editor stephanies@hawaiihomemag.com


This is an older question but things have changed. Its a common misconception on what the contribution cap is. A few things.
In 2014, the IRS did not adjust the maximum contribution from the previous year which include 401(k) accounts, 403(b) accounts, most 457 plans, and Thrift Savings Plans, will be $18,000, up $500 from $17,500.
Savers and investors aged 50 or older can take advantage of a catch-up contribution. In 2015, taxpayers who meet this age-based criterion can contribute an additional $6,000 above the regular maximum of $18,000, thus you can contribute a maximum of $24,000 into these tax-advantaged accounts.
The total contribution limit, including employer contributions, has increased to $53,000
You can actually contribute up to 53k (including matching) so the exact amount you contribute from your actual income may end up being more or less than 24k. If you get a poor employer match you can actually contribute more but it would go in as after tax dollars and not claim the tax deduction.
Note: after tax does NOT equal Roth.
However if your a high salaried individual you can use this as a potential loop hole for funding a Roth IRA. Chances are if your making enough money to contribute 53k Total Contributions then your not going to qualify for a roth. However once you retire (or possibly before depending on the plan withdraw terms) you can roll the after tax money into a Roth IRA. This is a gray area on the tax policy. The IRS may come back and change their mind about this. If considering this option talk to a tax adviser.


Articles by Anne Marie van Swinderen
Guest Articles
Tuesday
November 3 2020 Keeping Finance in the Family: How Intra-Family Accounts Can Help Low-Income Customers During COVID-19 – and Beyond
Banks in emerging countries often struggle to generate active usage of the accounts they offer to young people. Yet as Anne Marie van Swinderen at L-IFT points out, financial diaries research has shown that young people save frequently and significantly – especially when their earnings rise. She explores how intra-family accounts could help banks serve this challenging demographic during COVID-19 and in the longer term – while also expanding their financial services to other members of the family.


National Colorectal Cancer Awareness Month, held in March each year, offers healthcare providers who care for patients with diseases of the colon and rectum a valuable opportunity to educate their community about these diseases and promote awareness of the importance of colorectal cancer screening, prevention, and treatment. These efforts may also provide a window into the profession and encourage others to consider careers in the field of colon and rectal surgery.


Cylert is the brand name of the generic medication pemoline. Cylert is used to help in the treatment of children who are dealing with attention deficit hyperactivity disorder (ADHD). It is often recommended that Cylert only be prescribed as part of a comprehensive treatment plan that offers both psychological and educational support to help the child to become more stable. In its generic form, Cylert is a white, tasteless, odorless powder that is relatively insoluble in water, chloroform, ether, acetone and benzene.
Cylert is subject to control under the Drug Enforcement Act as a Schedule IV drug. While the drug did not demonstrate a potential for self-administration in clinical animal trials, it is closely related to other psycho-stimulants that have a known dependence. This suggests that psychological and/or physical dependence and tolerance can occur with Cylert. There have also been isolated reports in the industry of transient psychotic symptoms occurring in adults following the long-term misuse of excessive oral doses of Cylert and its generic equivalent. As a result, it is imperative that the medication is given to emotionally unstable patients only when closely monitored as they may increase the dosage on their own initiative.


Philippines: Impact of COVID-19 on Micro, Small, and Medium Enterprises (MSMEs)
The extended community quarantine imposed by the government to contain the spread of COVID-19 has adversely affected MSMEs in the Philippines. This report outlines the impact of the pandemic on MSMEs and provides recommendations for policymakers to support their recovery.
Indonesia has been the hotbed for FinTech innovations across the ASEAN region. However, like all other businesses, FinTechs in the country too have been struggling to cope with the Pandemic. In this study, we highlight the impact of the pandemic on FinTechs in Indonesia.
COVID-19: A harbinger of consumer behavior shifts among FinTech users
The blog analyzes the impact of the COVID-19 on two major categories of FinTechs—credit and savings FinTechs. We analyze the immediate impact of the pandemic and the ensuing regulatory changes on FinTechs along with some long-term changes in consumer behavior that can have a systemic adverse impact. We close by recommending data-driven measures that credit and savings FinTechs should take today to control and arrest such adverse changes in consumer behavior.
Amid the COVID-19 crisis, agricultural activities in India were exempt from restrictions. However, the lockdowns led to various disruptions in the supply chain. This blog summarizes the impact of COVID-19 on different sub-sectors and highlights the measures the government took to address the problems of farmers.
Impact of the COVID-19 pandemic on CICO agents- Uganda report
This report explores the impact of COVID-19 on CICO agents in Uganda. It also highlights the strategies agents adopted to stay afloat during the pandemic and provides recommendations for policymakers and financial service providers to support these agents better.
We are looking up to business correspondents in the pandemic; but what are they looking at?
The business correspondent (BC) network in India has become indispensable for last-mile financial service delivery across urban and rural centers. In light of the current pandemic, our note highlights the challenges BC agents face while providing services in far-flung unbanked areas.


Bacopa monnieri, also called brahmi, water hyssop, thyme-leaved gratiola, and herb of grace, is a staple plant in traditional Ayurvedic medicine.
Bacopa monnieri has been used by Ayurvedic medical practitioners for centuries for a variety of purposes, including improving memory, reducing anxiety, and treating epilepsy.
Benefits -
have anticancer properties


A journey to “South”: Becoming third world women educators
Thesis
Lopes Duraes, Bruna. (2019)
A journey to “South”: Becoming third world women educators[Thesis]. https://doi.org/10.26199/6gys-he10
Authors Lopes Duraes, Bruna Qualification name Doctor of Philosophy (PhD) Abstract
This thesis is an invitation to think about education as part of a progressive social movement. We, third world women educators, participate in a struggle over the politics of recognition and distribution. This thesis investigates the stories of five women teachers, including my own, who come from so-called third world countries. The research applies several theoretical perspectives on the lives of these women to assist me in understanding the experience of third world women teachers in times of change. The research draws on philosophical works of Henri Lefebvre, sociological perspectives of Dorothy Smith, and the cultural theory of Michel de Certeau and adopts a feminist neo-Marxist and cultural approaches as a way of explicating relations of power in the everyday, while articulating conceptual tools that challenges domination. This research comes from the perceived need to approach teaching differently (Sachs, 2016) and the thesis provides a platform through which to contribute to the ongoing debate in education by reimagining teaching differently as I undertake a journey “South” (Connell, 2007). I use “South” as a metaphor, to investigate the lived experiences of teachers who come from postcolonial nations, such as South America (Chile and Brazil) and South Africa. I represent these teachers’ “journeys” to Australia, as I critically engage with their stories of becoming teachers in this landscape. By undertaking an inquiry to South, this thesis challenges hegemonic forces in education, by representing the voices of third world women educators in education.
Keywords third world countries; women teachers; neoliberal policies; narrative inquiry; institutional ethnography; responsibility; professionalism Year 2019 Publisher ACU Research Bank Digital Object Identifier (DOI) https://doi.org/10.26199/6gys-he10 Research Group School of Education Final version Publication dates 01 Jan 2019
https://acuresearchbank.acu.edu.au/item/8v242/a-journey-to-south-becoming-third-world-women-educators
Download files 0total views 2total downloads 0views this month 2downloads this month These values are for the period from 19th October 2020, when this repository was created.


In a recent PwC innovation survey, seven out of 10 executives agreed that having a well-defined innovation process is key to building an innovation culture. But that is not easy, even for companies like Artefact, whose bread and butter is design and innovation.
Even we, the experts, find it challenging to organize our inspiration without inadvertently losing ideas. We believe that ideas get stronger when we incorporate input from other disciplines, yet we have not found a consistent way to integrate feedback into the design process. Finally, while we constantly evolve the frameworks and tools that help us make decisions, over time we lose the background that led us on a certain path. Until now.
Today, together with our sister company 10,000ft, we are unveiling 10,000ft Insights, a shared project space for creative teams and organizations. It enables easy collecting and sharing of ideas, facilitates timely and relevant feedback, and helps organizations retain knowledge in the ever-faster pursuit of innovation.
10,000ft Insights is already amping up our work at Artefact. Both internal innovation initiatives and client collaborations benefit from what we can now deliver even better — stronger collaboration between teams, clarity and transparency in the design process, and ultimately, decisions, directions and successes we can confidently stand behind. Try it.


The Canadian Energy Pipeline Association (CEPA) represents Canada’s transmission pipeline companies who operate approximately 119,000 kilometres of pipeline in Canada and 14,000 kilometres in the United States. CEPA members move approximately 1.2 billion barrels of liquid petroleum products and 5.4 trillion cubic feet of natural gas each year.
CEPA’s mission is to continually enhance the operating excellence, business environment and recognized responsibility of the Canadian energy transmission pipeline industry through leadership and credible engagement between member companies, governments, the public and stakeholders. Our members’ relationships with Indigenous groups are a critical component to operationalizing this mission. These relationships span the entire country and continue to evolve as aspirations regarding reconciliation become reality. As leaders in the transportation of energy we recognize the value in building and maintaining mutually beneficial, long-term relationships with Indigenous groups through principled approaches to Indigenous relations.