Egyptian Natural Gas Holding Company (EGAS) is to put forward a global tender this week to rent a third gasification vessel with the capacity of 750 million cubic feet of gas per day.
Minister of Petroleum and Mineral Resources Tarek El-Molla said to local media that the third vessel will contribute to bridging the gap between demand and supply, helping to meet local market needs.
He added that the vessel will supply gas required for economic development over the next five years.
FSRU Höegh Gallant - Image: Höegh LNG
According to El-Molla, the vessel will dock at Sumer, in the Ain Sokhna terminal, where it will receive liquid gas shipments, convert the liquid into a gas state, and then pump the gas into the national gas grid pipelines.
The minister pointed out that the third vessel will boost import capacity to 1.95 billion cubic feet of gas per day, instead of the current capacity of 1.2 billion, which is imported through two gasification vessels also docked in Ain Sokhna. He added that importing more gas will stabilise supplies for electricity and other industries within the country.
According to studies prepared by specialised institutions, Egypt can achieve self-sufficiency with regards to natural gas by 2022, at which point importing could cease.
Egypt currently has two gasification vessels in Ain Sokhna. The first is a Norwegian ship, which has a capacity of 500 million cubic feet per day. The second vessel is owned by Singapore’s BW, which has a 700 million cubic feet capacity.
Egypt’s current production of natural gas is 4 billion cubic feet per day, and will remain so until the end of the current fiscal year.
The total volume of compensatory wells that were linked to the production does not exceed 700 million cubic feet per year, while the monthly decline in the productivity of Egyptian wells stands at 100 million feet per month.
Source: DailyNewsEgypt


Quick Reference
Affecting two parties; often used in relation to negotiations or agreement between two countries. International relations are often conducted between two countries, seeking mutually beneficial solutions to disputes, and improved collaboration and cooperation. Bilateralism can be contrasted with unilateralism, and many international organizations are designed to encourage multilateral negotiations. Bilateral agreements can be easier to negotiate, involving only two parties, but outcomes can be seen to serve a narrow set of interests. Bilateral negotiations have a similar interpretation in domestic politics. The prime ministerial style of Tony Blair, involving an emphasis on bilateral meetings between himself and ministers, was seen to reduce the influence of the Cabinet and undermine collective decision‐making.
Subjects: Politics.


Assessment | Biopsychology | Comparative |Cognitive | Developmental | Language | Individual differences |Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |
The term
phenomenology in science is used to describe a body of knowledge that relates empirical observations of phenomena to each other, in a way that is consistent with fundamental theory, but is not directly derived from theory. For example, we find the following definition in the Concise Dictionary of Physics: Phenomenological Theory. A theory that expresses mathematically the results of observed phenomena without paying detailed attention to their fundamental significance. [1] See alsoEdit ReferencesEdit ↑ Thewlis, J. (Ed.) (1973). Concise Dictionary of Physics. Oxford: Pergamon Press, p. 248.
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In the West, an active monsoon pattern features scattered showers from the Desert Southwest to the interior Northwest. Heat lingers across the northern half of the region, where numerous large wildfires are in various stages of containment. On the Plains, hot, mostly dry weather is maintaining stress on both rain-fed and irrigated summer crops. Across the northern Plains, heat is also promoting winter wheat maturation. In the Corn Belt, scattered but highly beneficial shower activity is occurring across the upper Mississippi Valley. Meanwhile, cloudy weather prevails along the Ohio River. Across the remainder of the Midwest, extremely dry conditions and near- to above-normal temperatures are maintaining severe stress on reproductive summer crops. In the South, widespread cloudiness and scattered showers accompany near- to below-normal temperatures. Drought-easing showers are heaviest across parts of the interior Southeast, including eastern Kentucky.
Outlook: During the weekend and early next week, heat will persist on the Plains and intensify across much of the East and Midwest. Several days of 100-degree heat can be expected on the central Plains, and triple-digit readings may briefly return to the upper Midwest. During the next 5 days, little or no rain can be expected on the Plains and across the driest areas of the southern and eastern Corn Belt. Meanwhile, scattered showers will affect the Intermountain West and the upper Midwest. Across the Southeastern and Mid-Atlantic States, additional rainfall totals could reach 1 to 3 inches. The NWS 6- to 10-day outlook for July 18-22 calls for near- to above-normal temperatures nationwide, except for cooler-than-normal conditions along the Pacific Coast. Elsewhere, a complex rainfall pattern will result in the likelihood of above-normal rainfall in several areas, including the Pacific Northwest, southern Rockies, western Gulf Coast region, and Great Lakes and Eastern States, while drier-thannormal weather can be expected across the northern half of the Plains and from California into the Great Basin.


Abstract
14-3-3 Proteins may function as adapters or scaffold in signal-transduction pathways. We found previously that protein kinase C-ζ (PKC-ζ) can phosphorylate and activate Raf-1 in a signalling complex [van Dijk, Hilkmann and van Blitterswijk (1997) Biochem. J.
325, 303-307]. We report now that PKC-ζ-Raf-1 interaction is mediated by 14-3-3 proteins in vitro and in vivo. Co-immunoprecipitation experiments in COS cells revealed that complex formation between PKC-ζ and Raf-1 is mediated strongly by the 14-3-3β and -θ isotypes, but not by 14-3-3ζ. Far-Western blotting revealed that 14-3-3 binds PKC-ζ directly at its regulatory domain, where a S186A mutation in a putative 14-3-3-binding domain strongly reduced the binding and the complex formation with 14-3-3β and Raf-1. Treatment of PKC-ζ with lambda protein phosphatase also reduced its binding to 14-3-3β in vitro. Preincubation of an immobilized Raf-1 construct with 14-3-3β facilitated PKC-ζ binding. Together, the results suggest that 14-3-3 binds both PKC-ζ (at phospho-Ser-186) and Raf-1 in a ternary complex. Complex formation was much stronger with a kinase-inactive PKC-ζ mutant than with wild-type PKC-ζ, supporting the idea that kinase activity leads to complex dissociation. 14-3-3β and -θ were substrates for PKC-ζ, whereas 14-3-3ζ was not. Phosphorylation of 14-3-3β by PKC-ζ negatively regulated their physical association. 14-3-3β with its putative PKC-ζ phosphorylation sites mutated enhanced co-precipitation between PKC-ζ and Raf-1, suggesting that phosphorylation of 14-3-3 by PKC-ζ weakens the complex in vivo. We conclude that 14-3-3 facilitates coupling of PKC-ζ to Raf-1 in an isotype-specific and phosphorylation-dependent manner. We suggest that 14-3-3 is a transient mediator of Raf-1 phosphorylation and activation by PKC-ζ. mitogen-activated protein kinase platelet-derived-growth-factor receptor scaffold/adapter protein signalling complex signal transduction The Biochemical Society, London © 2000


San Francisco recently enacted two sweeping ordinances that are being referred to as the “Retail Workers Bill of Rights” (you can find the ordinances here and here). The new laws impose strict new requirements on retail employers and establishments in the City of San Francisco. While the ordinances became effective on January 5, 2015, employers will have until July 5, 2015 to comply. Below is an overview of the new laws’ requirements.
Affected Employers—“Formula Retail Establishments”
The new laws apply to “Formula Retail Establishments” with at least 20 retail sales establishments worldwide and 20 or more employees in San Francisco. The term “Formula Retail Establishment” applies to retail sales or service establishments that maintain at least two of the following features: (1) a standardized array of merchandise, (2) a standardized façade, (3) a standardized décor and color scheme, (4) uniform apparel, (5) standardized signage, and (6) a trademark or servicemark.
New Requirements for Formula Retail Establishments Offering Additional Hours Worked to Current Part-Time Employees – Under the ordinances, employers must offer, in writing, additional work to qualified part-time employees before hiring new employees or using contractors or staffing agencies to perform additional work. Employers only need to offer part-time employees up to the number of hours required for the employee to reach 35 hours worked per week. Employers must retain offers of additional hours to employees for at least three years. Good Faith Initial Estimate of Minimum Hours and Two Weeks’ Notice of Schedules – Prior to the start of employment, employers are required to provide new employees with a good faith written estimate of the employee’s expected minimum number of scheduled shifts per month and the days and hours of those shifts. The estimate need not include on-call shifts. The ordinances also require employers to provide employees with their schedules two weeks in advance. Employers must retain employee work schedules and payroll records for at least three years. Notice of Schedule Changes and “Predictability Pay” for Schedule Changes – Employers must provide employees with notice of schedule changes. If the employer changes an employee’s schedule on less than seven days’, but more than 24 hours’ notice, the employer must provide an extra hour of pay for each changed shift. A “schedule change” is defined as changing the date or time of a scheduled shift, cancelling a scheduled shift, or requiring the employee to work when he or she was previously unscheduled. However, an employer does not need to provide “predictability pay” when it extends an employee’s scheduled shift to include overtime hours.
If the employer changes the employee’s schedule on less than 24 hours’ notice, the employer must provide an additional two hours of pay if the changed shift is four hours or less or an additional four hours of pay if the changed shift is longer than four hours.
Key Exceptions: Employers do not have to provide “predictability pay” if any of the following conditions apply: Another employee was scheduled to work, but is unable to work due to illness, vacation, or other approved time off, and the employee failed to provide the employer with at least seven days’ notice. Another employee was scheduled to work, but failed to report to work on time or is sent home as a disciplinary action. The employee requests a change in shifts or trades shifts with another employee. Emergency situations: the business closes due to threats to safety, public utility failure, a natural disaster, or a state of emergency declared by the Mayor or Governor. On-Call Shift Pay – If an employee is required to be “on-call,” but is not called in to work, the employer must provide the employee with two hours of pay if the on-call shift lasted four hours or less, or four hours of pay if the on-call shift exceeded four hours. Equal Treatment for Part-Time Employees – Employers must provide equal treatment, subject to certain qualifications, for full-time and part-time employees regarding: (1) starting hourly wage; (2) access to paid and unpaid time off; and (3) eligibility for promotions. However, hourly wage differentials are permissible if they are based on reasons other than part-time status, such as seniority or merit systems. Further, employees’ time off allotments may be prorated based on hours worked. Workplace Posting – Formula Retail Establishments are required to post at the workplace a notice informing covered employees of their rights under the new laws. Require Contractor Compliance – Covered employers must include in service contracts with contractors for janitorial or security services: (1) a provision requiring the contractor to comply with the new laws; and (2) a copy of the new laws. Penalties for Non-Compliance
The San Francisco Office of Labor Standards Enforcement (“OLSE”) is charged with implementing and enforcing the ordinances. The OLSE can order compliance, impose administrative fines, and require employers to pay lost wages and reimburse the City’s enforcement costs. Additionally, the ordinances authorize the City Attorney to bring a civil action against employers for violation of the laws. The City may recover payment of lost wages, civil penalties, reinstatement of employment, and reasonable attorney’s fees and costs. Notably, if an employer fails to maintain or retain records as required by the new laws, the City will presume that the employer did not comply with the ordinances.


TEAM CHARTER
Real-Time Inundation Mapping Evaluation (R-TIME) Team
Vision: The provision of real-time inundation maps will enhance community resiliency by
enabling decision makers to make informed decisions to better mitigate the impact of floods.
Mission: Evaluate demonstration projects in which real-time inundation maps are currently
being generated by the National Weather Service (NWS) and others. NWS demonstration projects are
currently being conducted on the Red River, St. Johns River, Tar River, and Susquehanna River
Basins. Assess the capabilities, limitations, and resources required for each of these
projects/alternatives. Based on the response to the Request for Information (see attachment) and
the evaluation of current mapping activities, recommend the approach (if any) most suitable for
inclusion in real-time operations. Define what information should be provided and how, how the
information will be depicted, the frequency with which the information should be generated, and
the format(s) in which the information should be made available.
Scope of Authority/Limitations:
This team operates under the authority of the Director of the Office of Hydrologic Development,
and the NOAA Hydrology Program Manager.
Recommendations must be scientifically sound, efficient and cost effective.
Analyses must be objective and unbiased.
Past or current practices, and organizational allegiances among the team members, must not be
allowed to influence either the evaluation or the recommendations.
The team will consult with internal and external partners and customers as needed.
Consensus among team members, as agreed upon by the team, is required for a decision to be made
or a recommendation to be adopted. In situations where the team can not achieve consensus, and a
decision must be made to move the team's activities forward, the NOAA Hydrology Program Manager
will adjudicate the impasse.
Travel expenses, if needed, will be covered by the NOAA Hydrology Program.
Success Criteria/Deliverables:
The team will produce a final report consisting of HOSIP/OSIP documentation through Stages 1, 2
and 3 required to implement the recommended solution. The team leader will brief the team's
findings and recommendations to the NOAA Hydrology Program Manager.
Commencement & Termination Date:
The team will be formed and commence activities by October 15, 2006 and deliver its final
report and briefing by September 30, 2007.
Suggested Team Members:
MARFC
Joe Ostrowski
SERFC
Jonathan Atwell
OCWWS
Tom Donaldson
NCRFC
John Halquist
CNRFC
Thea Minsk
OHD
Cecile Aschwanden
OHD
Reggina Cabrera (Team Leader)


DiGeorge syndrome, which is caused by a microdeletion of 1.5 to 3.0 megabases on the long arm of chromosome 22, has an incidence of approximately 1:4,000 to 1:5,000 live births. The phenotypic spectrum of this disorder includes congenital heart defects, immunodeficiency due to thymic hypoplasia or aplasia, transient or permanent hypocalcemia due to parathyroid hypoplasia or aplasia, developmental retardation, and psychiatric disorders. Dental aspects in these patients include skeletal malformations, velopharyngeal insufficiency with or without cleft palate, small mouth, and hypotonus orofacial musculature, as well as impaired salivary flow. Enamel aberrations related to hypocalcemia may result in a higher frequency of dental caries. Based on a series of five patients, the medical and dental aspects that have to be considered in the care of patients with DiGeorge syndrome are presented. (Quintessence Int 2010;41:551–556)


Abstract
Abstract Olfactory-like receptors (OLRs) have been shown previously to be expressed in adult and foetal human tongue. This prompted us to verify the hypothesis if OLRs were involved in taste perception. In the present work, the mouse orthologs of OLR genes expressed in adult and/or foetal human tongue were identified. Analysis of their genomic localization and of their primary sequence features using bioinformatics did not reveal any shared remarkable characteristic. The expression of eight of these orthologs ( S25/mJCG1, K42, mJCG2, mJCG3, P2/mJCG5, P3/mJCG6, mT09m/mJCG9, K21/mTPCR85 and mTPCR06) was studied in three types of mouse papillae as well as in the olfactory epithelium. It was found that all of them are expressed in olfactory epithelium and that only three of them ( S25/mJCG1, K42/mJCG2 and mTPCR06) are expressed in papillae. However, despite many efforts it was impossible to detect without ambiguity the presence of OLR mRNAs in taste receptor cells nor in surrounding tissues by in-situ hybridization. Hence, the studied OLRs very likely play in taste papillae other roles than taste perception.


Temp car insurance comes in several forms - temporary or month-to-month are the primary examples. Temporary car insurance covers periods ranging from 1 to 28 days. Month-to-month cover, also known as pay-as-you-go, covers periods longer than 28 days, but shorter than the one-year terms of annual insurance policies. These temp options allow drivers to get cover when they don't require year-round coverage and don't want to pay for insurance they won't use or need. Pay-as-you-go insurance also offers more flexibility to young drivers, who may otherwise have difficulty finding the type of cover they need.
Drivers who need to drive another car for short periods of time often purchase temporary insurance. Many annual policies exclude cars not listed on the policy. Thus, drivers can find themselves in the unfortunate position of driving without insurance, even though they pay for annual insurance, albeit the wrong kind. Temporary cover ensures that drivers don't experience this unenviable situation. Some comprehensive annual policies may include third party cover on other vehicles, subject to restrictions, in which case drivers may not need temporary cover. For drivers without such policies, temporary cover allows them to fulfil legal requirements for a modest cost. Indeed, some choose to use temporary insurance as a defensive tactic, to safeguard their no claims bonus and ensure that annual policies won't increase should they have an accident.
Temporary insurance may be used for many reasons, but essentially it's about fulfilling legal obligations. Laws dictate that every driver must have third party cover at minimum, providing protection for the person and property of others involved in an accident. For those who drive at all times, year-round insurance suits their needs and fulfils this basic requirement. That's sufficient for insuring a vehicle driven all the time, but what about irregular or unexpected driving? This can come at any time - driving a borrowed car whilst one's own car is being serviced, borrowing a van to transport things from one place to another, sharing the driving on a long trip, even offering to serve as designated driver in someone else's vehicle.
For more zany information about temporary car insurance why not try this crazy site?


How Employees Put Their Company at Risk
Despite the abundance of publicity over organizations that have been hacked—Target, the U.S. Office of Personnel Management and Ashley Madison, to name just a few—workers still take part in risky device usage that could potentially expose their company to a variety of threats, according to a recent survey from CompTIA. The survey report, "Cyber Secure: A Look at Employee Cybersecurity Habits in the Workplace," reveals that a surprisingly large percentage of employees receive no cyber-security training on the job. As a result, they aren't as familiar with the dangers of malware as they should be, nor are many of them aware of proven protective measures such as two-factor authentication. Meanwhile, many employees consider their work and personal devices as one and the same—often calling up work-related data while connecting through vulnerable public WiFi networks. "The ecosystem of consumer technology is swelling, and the lines that once delineated device use are fading," the report states. "Employees use a variety of personal and corporate tools, but work devices aren't solely used for work purposes [and vice versa]. This blending of data puts the onus on organizations to ensure that employees understand what constitutes 'good' cyber-security hygiene and are equipped with the skills to demonstrate it." An estimated 1,200 U.S. employees took part in the research.


Caffeine is a mind-altering drug common in foods and beverages. While most people are familiar with the buzz and alert feelings that immediately follow a cup of coffee, not everyone understand the complex biological reactions that caffeine causes in the body. Caffeine is absorbed in the body very quickly, and can have an immediate effect on your central nervous system.
Caffeine and the Body
Caffeine is quickly absorbed into the body and is immediately distributed to the brain, according to Medline Plus. Unlike some chemicals, caffeine does not accumulate in the bloodstream or other parts of the body, but is instead excreted in urine within a few hours of consumption. As caffeine passes through the brain, signals are sent to the adrenal glands that cause them to pump stress hormones through your body in the imitation of a fight-or-flight response.
Speed
Determining an exact speed or time for caffeine absorption is difficult due to individual factors such as age, body weight, caffeine sensitivity and diet. However, according to the ABC website, women metabolize caffeine at a rate 20 to 30 percent quicker than men. As your blood transfers the caffeine from your gastrointestinal tract to your brain, it increases your total metabolic rate, reaching its maximum concentration within an hour of consuming.
Effects
Although caffeine is widely available in products ranging from sodas to chocolate and coffee, the Teen’s Health website recommends capping your dosage to 300 milligrams a day. As caffeine begins to stimulate your central nervous system, feelings of awareness, energy and elevated mood can often occur, followed by a crash of low energy and tiredness. Due to its addictive properties, caffeine can form dependencies and addictions in individuals who consume as little 100 milligrams a day, leading to withdrawal symptoms such as tiredness, irritability and headaches.
Safety Concern
Reduce your risk of negative symptoms by limiting your caffeine intake, and never drinking caffeinated beverages on an empty stomach. If you feel that you may be dependent on caffeine, talk to your doctor about healthy alternatives to your eating and drinking habits.


Spurred by recent governmental transitions from dictatorships to democratic institutions, this highly original work argues that negotiated civil society-oriented transitions have an affinity for a distinctive method of constitution making_one that accomplishes the radical change of institutions through legal continuity. Arato presents a compelling argument that this is the preferred method for rapidly establishing viable democratic institutions, and he contrasts the negotiated model with radical revolutionary change. This exceptionally engaging work will be of interest to students and scholars of comparative politics, constitutional law, and East European studies, as well as to political scientists and sociologists.


The term S&P 900 Composite Value refers to an index that includes a subset of the securities found in the S&P 400 and S&P 500 Indices. The S&P 900 Value is published and maintained by S&P Dow Jones Indices.
The S&P 900 is a composite index that includes mid to large-cap stocks in the United States' market. The S&P 900 Value is a subset of the securities appearing in the S&P 900, which includes the S&P 400 and S&P 500 indices.
The components of this index were selected based on their value potential with respect to sales, earnings relative to price, and momentum. These three criteria determine the security's value score, which is used when selecting securities for inclusion in the Value Index. First launched on December 16, 2005, the index is made up of approximately 670 securities. The composite is designed to provide investors with a measure of the performance of mid to large-sized U.S. value equities. The performance of the index can be tracked using the stock ticker SPUSNV.
S&P Dow Jones first determines whether a stock appearing in the S&P 900 has value potential based on sales, earnings and momentum. These 670 securities are then placed in the Value index. Those securities with the highest value scores (approximately 200 securities) are placed in the Pure Value index. In other words, the Pure Value index is a subset of the Value index with the highest value potential.


This course begins with an overview of the Earth's systems "geophysical, atmospheric, oceanic, and ecosystems" as they exist independently of human influence. Following this introduction, the course explores the effect that human activities have on the different natural systems. Topics include:
human population growth and resource use, increasing competition for fresh water, and climate change.
Each of the programs features two case studies following top scientists in the field. The course includes video programs, a coordinated website, the course text online, five interactive simulations, background on the scientists whose research is documented, a professional development guide for high school science teachers and additional resources.
This workshop will be offered for 3.0 CEUs. Participants will be enrolled in Canvas and access the course materials through this gateway site. They will be expected to engage with all the course materials including 13 half hour video sessions plus support materials, website interactives, and wrap-around activities totaling at least an additional 24 hours, but will not be required to submit homework, papers, projects, etc.
A non-graded discussion forum will be available to participants as an outlet for ideas and peer interaction. A participant survey/open-ended test questions/evaluation form will serve as the end point of the noncredit course and will document participation. Once the participant has completed the survey/test form, they will notify the course monitor who will review and send a certificate documenting the CEUs.
Noncredit courses do not produce academic credit nor appear on a Colorado State University academic transcript.
Important Information
There is no refund available for this noncredit course once the registration is processed. Students will receive an email containing their Canvas login information soon after registration.
Instructors
Barry Carroll
Barry.Carroll@Colostate.edu


Continue Reading
Using a formula that astrophysicist Greg Laughlin had created, the planets have been given values in terms of currency. The Earth is valued at five quadrillion dollars, as of February 2011, making it the most expensive among 1,235 other planets.
Professor Laughlin used vital statistics such as each planet’s age, mass and temperature to come up with the formula. According to his calculations, Mars is only worth $14,000, while Venus is barely worth a cent. The reason for this is that these planets have inhospitable environments.
Despite the low price tags of other planets in space, purchasing them is not allowed because of a treaty established by the United Nations in 1967, the Outer Space Treaty. With a total of 102 state parties, this treaty forbids any nation from claiming territorial sovereignty over any part of outer space, including the moon and other celestial bodies.Learn more about Astronomy


While exposure to fibers and particles has been proposed to be associated with several different lung malignancies including mesothelioma, the mechanism for the carcinogenesis is not fully understood. Along with mineralogical observation, we have analyzed forty-four major and trace elements in extracted asbestos bodies (fibers and proteins attached to them) with coexisting fiber-free ferruginous protein bodies from extirpative lungs of individuals with malignant mesothelioma. These observations together with patients’ characteristics suggest that inhaled iron-rich asbestos fibers and dust particles, and excess iron deposited by continuous cigarette smoking would induce ferruginous protein body formation resulting in ferritin aggregates in lung tissue. Chemical analysis of ferruginous protein bodies extracted from lung tissues reveals anomalously high concentrations of radioactive radium, reaching millions of times higher concentration than that of seawater. Continuous and prolonged internal exposure to hotspot ionizing radiation from radium and its daughter nuclides could cause strong and frequent DNA damage in lung tissue, initiate different types of tumour cells, including malignant mesothelioma cells, and may cause cancers.(Communicated by Takashi SUGIMURA, M.J.A.)


In
US News & World Report, William Broman, a current biomedical engineering major at George Washington University, offers a reality check about the financial burdens facing many college graduates in the form of hefty college loan payments. The data, he says, supports the notion that one of the quickest ways for graduates to eliminate their college debt is to enter a STEM field.


The study - presented at the ESPEN Congress on Nutrition and Metabolism – examined the association between previous eating habits and current nutritional status in elderly people, finding that for every percentage of energy intake that came from dietary fat resulted in a 7% higher risk of being malnourished 10 years later.
Led by Lisa Loderstrom from Uppsala University in Sweden, the research team followed more than 700 people from mid-Sweden for an average of 10 years – revealing a relationship between levels of dietary fat intake and the later risk of malnourishment.
Study details
Loderstrom and her colleagues followed 732 men and women aged between 44 and 80 years old from 1997 to 2009. All participants were asked to provide information on dietary habits lifestyle information at the beginning of the study. This included information on potential risk factors form malnutrition such as: sex, age, BMI, tobacco use, and percentage energy intake from fats, carbohydrate, protein and alcohol.
The team followed the participants for an average of 10 years, before conducting a final nutritional assessment – using the Mini Nutritional Assessment (MNA).
The team reported that while the percent of energy gained from carbohydrate, protein or alcohol were not associated with the risk of malnourishment; smoking, BMI, and percentage of energy from fat were all significantly associated with the later risk of malnourishment.
After adjusting for the risk of smoking and BMI, the team revealed that for each additional percentage of energy from fat the risk of later malnourishment increases by 7%.


D.C. Metropolitan Police Chief Cathy Lanier is arguably the most popular city official in the District.
Her job approval is high, some have floated a run for the mayor’s office, and she’s the epitome of no-nonsense competent management. In a city experiencing ceaseless ethical lapses and serial scandals tainting the local public sector, she’s the town sheriff who saddles a noble steed. Lanier is personable, likable and her own best representative.
She has a straight-talking style and common-sense attitude. For that reason, Lanier’s often misguided and random utilization of special emergency powers granted the police chief under the District’s Emergency Suspension of Liquor Licenses Act of 2005 is an oddly uncharacteristic misstep.
The law allows closure for up to 96 hours of an establishment that poses an “additional imminent danger to the health and welfare of the public” with “no immediately available measure to ameliorate” and a finding “that there is a correlation between increased incidents of crime within 1,000 feet of the establishment and the operation of the establishment.” The law further provides that this latter “determination shall be based on objective criteria, including incident reports, arrests, and reported crime, occurring within the preceding 18 months.”
A license suspension under this provision remains in effect until the Alcoholic Beverage Control (ABC) Board can expedite review as related to liquor permit rules.
Granting an extraordinary special ability to singlehandedly impose emergency closures was not intended as a regulatory penalty mechanism, but to protect the public from serious ongoing danger not achievable through standard actions.
Recent usage of this unique power illustrates the controversy over its increasingly irregular imposition.
Two weekends ago, following police response to an alleged after-hours sexual assault complaint at the long re-launched historic jazz venue Bohemian Caverns that first opened at the corner of 11th and U streets, N.W., in 1926, the decision to invoke an emergency closure was puzzling. While the accusation that a male employee assaulted a woman invited to the location for drinks after the business had closed and without the authorization or knowledge of the owner is certainly troubling if true, there was no resulting threat to public safety extending to the surrounding area.
Likewise, the emergency closure earlier that week of Indulj Restaurant and Lounge one block away, following the gunshot wounding on an adjoining street of three male patrons, perhaps from a passing vehicle, also fails to meet the legal criteria. This act of random violence without prior occurrence, as unsettling as it may be, does not establish a pattern of incident or likelihood of repetition related to the venue’s operation.
The ABC Board terminated or allowed expiration of these closures.
As counterintuitive as it may seem, a criminal act committed either on the street or on premise does not automatically constitute an actionable standard under the law. A reflexive reaction without collecting or understanding relevant facts potentially results in both inappropriate closure and unwarranted business harm.
Temporary emergency shutdowns – numbering nine in 2011 and 14 this year among nearly 1,600 alcohol-licensed businesses – do not represent a thoughtful or consistent policy benefiting public safety. Instead, the closures strike observers as unduly haphazard and capricious, and inconsistent with the goal of protecting the community from continuing danger. Employment of this extreme measure is oftentimes not reflective of either the intent or requirements of the law.
Of note, churning out closure citations appears a newly overused routine, as evidenced by the cut-and-paste error on the Bohemian Caverns police order. The document, later revised, cited a “brazen shooting on the streets of the District of Columbia” as cause, not the actual incident.
Misapplying this law does not provide public safety, fails to meet the defined standard and suggests only a desire to implement a shortsighted public relations strategy. Imposing closures without a justifiably legitimate rationale undermines its rare use when appropriate.
Rather than conveying confidence that an actual threat is being addressed in a relevant manner, misuse leads to a false sense of protection and unduly taints both neighborhood and business as dangerous locale or enterprise.
Community interests are poorly served by this propagating police practice.
Mark Lee is a local small business manager and long-time community business advocate. Reach him at OurBusinessMatters@gmail.com.


The amount of energy stored in a given food per unit volume or mass. Fat stores 9 kilocalories/gram (gm), alcohol stores 7 kilocalories/gm, carbohydrate and protein each store 4 kilocalories/gm, fiber stores 1.5 to 2.5 kilocalories/gm, and water has no calories. Foods that are almost entirely composed of fat with minimal water (e.g., butter) are more energy dense than foods that consist largely of water, fiber, and carbohydrates (e.g., fruits and vegetables).


openDemocracy oD-UK oDR oD 50.50 democraciaAbierta Transformation OurBeeb More OurBeeb Happiness Debate Edited by William Davies
The happiness debate ran over the course of 2011, featuring sixteen articles from a range of policy thinkers, academics and critics. It interrogated the underpinnings of the government's new interest in our happiness, reflecting on what this might mean, how happiness is measured, and whether our wellbeing should be a concern for policy in the first place. A highlight of the happiness debate was an interview with Geoff Mulgan, former head of Tony Blair's policy unit, now Director of NESTA and a founder of Action for Happiness. These articles remain a valuable online resource for those seeking to think critically and widely about the emergence of a policy paradigm, which places our mental wellbeing at its heart.
See Davies' reflections on the debate, written at the conclusion of the series.


To clean a badly stained toilet bowl, scrub the toilet with baking soda, and use a pumice stone to remove mineral buildup. Clean the toilet bowl with vinegar and Borax on a regular basis to prevent additional stains. Typically, toilet bowls can be cleaned in under an hour.Continue Reading
Pour a cup of baking soda onto the stained areas of the toilet bowl, and allow the baking soda to remain undisturbed for several minutes. Scrub with a toilet brush to remove odors and surface stains.
Pumice stones are used to remove difficult stains, such as buildup caused by minerals in the home's water supply. Wear gloves, and gently scrub the stained areas with the stone to remove lime scales and other mineral buildup. Flush the toilet to remove any particles in the bowl.
Toilet stains are common in homes with hard water. To prevent new stains, add a cup of vinegar to the bowl, and allow it to remain for an hour. Flush the toilet, add 1/2 cup of Borax to the toilet bowl, and allow it to remain overnight. The next morning, clean the toilet bowl with a brush, and flush to remove the Borax.


"Intelligence and spirituality share features with wisdom, but they are not the same thing. One can be intelligent, yet lack practical knowledge. Spirituality is often associated with age, like wisdom, but most researchers tend to define wisdom in secular terms, not spiritual."
To break that down:
It is uniquely human. It is a form of advanced cognitive and emotional development that is experience-driven. It is a personal quality, albeit rare. It can be learned, increases with age and can be measured. It is probably not enhanced by taking medication.


Many different bacteria and viruses can cause conjunctivitis in the neonate. The two most feared causes are N. gonorrheae and Chlamydia acquired from the birth canal during delivery.Other agents causing Opthalmia neonatorum include Herpes simplex virus (HSV 2), Staphylococcus aureus, Streptococcus haemolyticus, Streptococcus pneumoniae.
Ophthalmia neonatorum due to gonococci (Neisseria gonorrhoeae) typically manifests in the first five days of life and is associated with marked bilateral purulent discharge and local inflammation. In contrast, conjunctivitis secondary to infection with chlamydia (Chlamydia trachomatis) produces conjunctivitis after day three of life, but may occur up to two weeks after delivery. The discharge is usually more watery in nature (mucopurulent) and less inflamed. Babies infected with chlamydia may develop pneumonitis (chest infection) at a later stage.Infants with chlamydia pneumonitis should be treated with oral erythromycin for 10–14 days.


Is there such a thing as a safe cigarette? Every year, millions die from smoking-related illnesses. Meanwhile, Big Tobacco continues to peddle their products to nearly a billion smokers worldwide with little accountability. In this climate of devastating addiction and astronomical death tolls, an alternative to dangerous tobacco-laden cigarettes has taken hold. E-cigarettes promise all the pleasures of smoking without the lethal consequences, and they've become so popular that even the world's largest cigarette manufacturers are desperate to climb aboard and seize a piece of the action.
Welcome Back, Big Tobacco, produced by the Canadian documentary series The Fifth Estate, investigates whether this new phenomenon is a true life saver or merely smoke and mirrors.
The filmmakers travel to the world's second largest tobacco company - British American Tobacco - and witness the work being done to produce the ideal vaping experience. Inside their top secret labs, over 800 million dollars is being spent on the development of e-cigarettes and other nicotine-based products which are designed to be less harmful than traditional cigarettes. But can a tobacco company really be relied upon to regulate itself, and encourage consumers to stop purchasing their most profitable cash cow?
Host Mark Kelly confronts a representative from the corporation's research and development department, and holds his feet to the fire on these crucial questions. He also speaks with members of the medical community who believe that such alternatives serve the public's best interest, regular citizens who have thrown away their cigarette packs in favor of a vaporizer, and Canadian health officials who remain on the fence regarding the ultimate safety of these products. Can e-cigarettes offer a real solution to a massive public health crisis, or do they serve as a gateway to get more young people hooked on smoking? The Health Canada organization contends that more studies are required before a final determination can be reached.
Strict regulations have banned Big Tobacco from becoming a player in Canada's e-cigarette industry, but that could soon change. In light of this,
Welcome Back, Big Tobacco provides a valuable service by examining this contentious issue from multiple perspectives and informing its viewers of all the potential risks and benefits involved.


A degree in #Criminology opens the doors to endless job opportunities. Without any doubt, this is one of the most fascinating and wonderful fields for students. After completing your graduation, you can pursue a career in areas like
social work, psychology, and forensic sciences. According to PayScale, an average salary for a criminology graduate is $45,000, which is more than a graduate of biology, linguistics, and gender studies. If you have decided to opt for this program, the following universities have invited applications for September 2016 intake. Framingham State University
This university is situated in Massachusetts. Its
College of Social and Behavioral Sciences invites applications for majoring in criminology. The institute promises to provide best ever study and research facilities to its graduates and post-graduates. As a student, you will study a wide array of criminal problems. Framingham State University awards scholarships to deserving and bright students. It is known for its outstanding and world-class learning opportunities. The University of Tampa
The University of Tampa is situated in Florida. On an average, the tuition fee is $27,391. Students of this university enjoy an
interdisciplinary environment and numerous internship opportunities. It is known for its great research facilities, allowing students to expand their knowledge. This institute has invited applications for Bachelor’s and Master’s in criminology, forensic sciences, business administration, biological sciences, linguistics, and engineering. You can apply for admission in the Criminology Scholars Program. This short-term course helps to develop an interest in the course before you opt for a regular degree program. State University of New York
It is situated in Cortland. This is one of the finest and
top ranked universities of New York. It has invited applications for a BA in Criminology, and an MA in Sociology. The faculty members prepare students for facing the challenges of tomorrow. Also, students learn the skills related to the criminal justice system. After the completion of your degree, you can further the #Education in any relevant discipline such as forensic sciences, social sciences, and others. Eastern Michigan University
Eastern Michigan University is based in Michigan. The estimated tuition fee is $13,040. Its
Department of Criminology and Forensic Sciences has talented faculty members. If you want to open the doors of good employment opportunities for yourself, a degree in criminology has no alternative. The Ph.D. faculty members remain busy with students in research projects. You can enjoy hands-on learning by opting for an internship after your graduation.


Learning To Forgive Learning to Forgive - Forgiveness is Not Inherent Learning to forgive implies that forgiveness is a learned process, not an automatic response. Our sinful nature (our flesh) has a high resistance to laying offenses aside. It prefers to take on an offense and use the energy that the offense brings with it, in every negative way. Every part of our un-renewed mind, our carnal mind, has a preference to take on an offense and a propensity to hold grudges, and seek its own sense of justice. Within the carnal mind, retaliation is most often not an option, but rather it's a driving force, it has to get even! Our flesh, unrenewed, unbridled, lacking illumination and understanding, prefers to be judge, jury, and executioner of the offender even when that offender is our own self. Learning to forgive - Christ Based Learning to forgive can only be fully achieved after we have accepted Jesus Christ as our Lord and Savior, otherwise we are simply acting according to our flesh. While we can learn to "forgive and forget" on a carnal level, as a good deed, but true forgiveness comes from the Spirit of Christ within us. Until our mind is renewed, until we are enlightened by His Holy Spirit, there remains a resistance, an enmity between us and God that will govern our every decision (Romans 12:2, Titus 3:3-5).
Learning to Forgive - Recognizing the "Old Man" Within Learning to forgive begins with understanding what God says about forgiveness in the Bible. Part of our learning process includes becoming aware that our flesh is truly hostile to God, must be brought under authority, and re-trained. Our "old man" must be put off and a "new man" must be put on (Ephesians 4:22, 24; Colossians 3:10-25). According to Scripture, we are the ones who must put off the old and learn of God and choose His ways. Thankfully we are not left alone to make decisions on our own because God, our Father, has sent His Spirit to help us. The Spirit dwells within us and teaches us (John 14:26). God has also given us His infallible Word, the Bible to teach us how to forgive. Learning to Forgive - A Personal Story There was a time in my life when I was extremely angry with my father. He had, in my opinion, done something that was beyond forgiveness. I knew what the Bible said. I had been taught all the reasons why we should forgive, but the reality was that I simply did not believe that forgiveness was all-encompassing. My anger and judgment were truly taking life from me. One day I said to the Lord, "I don't believe You forgave him. I don't believe You can love him either. He has stepped over the line! If You love him and forgive him, show me and I will consider forgiving him too." My thoughts immediately were focused on an unshelled pecan. I could almost feel the hardness of the shell, but I knew that inside of that shell the fruit was soft, pliable, and delicious. As I continued to consider the unshelled pecan, I was suddenly impressed with the fact that the hard shell was representative of the shell that sin puts around us, while the fruit remains intact within the shell. It is able to bear more fruit and to feed others when the shell is removed from it.
My spirit grasped what the Lord was showing me. The shell represented my father's hardened heart and his sin-altered lifestyle. All of a sudden, I understood forgiveness and healing from God's perspective. I understood for the first time that God loved my father for who he was, not for what he had become. God saw through the shell and His love was focused on who He had created my father to be. God recognized that my father's actions were driven by sin. Luke 23:34 echoed thru my head, "Father, forgive them, for they do not know what they do." I realized that I needed to separate my father's actions from his created being and I understood that I, like Jesus, could forgive the man without excusing his actions. All of a sudden, I didn't need to consider if I would forgive my father, it wasn't even a matter of when, it was an immediate response. God used a pecan for my "learning to forgive" lesson. He completed His process in me and I learned a lasting lesson.
I pray that the next time you see an un-cracked nut, God will use that to solidify your understanding of forgiveness, just as He did for me. I encourage you to examine yourself. Ask the Lord to reveal any shell that may have formed around you and, should you sense that there is one, ask Him to break it open and help you become all He created you to be!
What is your response?
Yes, today I am deciding to follow Jesus
Yes, I am already a follower of Jesus
I still have questions


Webers Law
Weber's Law is related to the Just Noticeable Difference (also known as the difference threshold), which is the minimum difference in stimulation that a person can detect 50 percent of the time. But Ernst Weber noted that for people to really perceive a difference, the stimuli must differ by a constant "proportion" not a constant "amount".
For example, if you are buying a new computer that costs $1,000 and you want to add more memory that increases the and the price $200 (a 20% increase), you might consider this too much additional money to spend. However, if you were buying a $300,000 house a $200 feature may seem like nothing. It might take an additional $10,000 to make you stop and think if it's too much to spend. In this example, the amount stays the same ($200), but the proportion changes and that's what makes the perceptual difference. Interested in a Graduate Psychology Degree?
You can get free information about Adler University's graduate psychology programs just by answering a few short questions.


Friday January 9Our God of Grace
Ephesians 2:4-5
Grace is God’s favor and love shown to mankind. We cannot earn it or ever be good enough to deserve it. To truly appreciate His grace, we need to comprehend certain truths about Him and ourselves.
First, God is perfectly holy, so He cannot allow sin in His presence. When Adam and Eve chose to eat the fruit from the forbidden tree, their intimate connection with Him was broken. Since all future generations inherited their sinful nature, every person is born with a disposition that is bent away from the Lord.
Next, God’s character is just. As a result, He requires payment for all sins. The penalty He demands is death (Rom. 6:23), not just physically but also spiritually through eternal separation from Him.
Finally, we have a merciful God who does not treat us as our actions deserve but instead extends His grace toward us. He devised a plan that would affirm His holy nature, satisfy His justice, and enable us to become members of His family: He sent His Son to accomplish our salvation. Born as a human being, Jesus lived a perfect life and completely fulfilled the Law. He alone qualified as the one who could satisfy divine justice. Christ took our place, bore our sins, and experienced God’s wrath over our rebellion—all so that we could be reconciled to the Father.
God made this provision for our salvation while we were still sinners (Rom. 5:8). Have you acknowledged your sinful state and received His forgiveness through faith in Jesus? If so, are you expressing ongoing thankfulness for His grace?
FEATURED RESOURCE
The Life Principles Bible
This Bible combines the wisdom of Scripture with the principles that guide Dr. Charles Stanley's life and empower his ministry. Order your copy.
Used with permission from In Touch Ministries, Inc. © 2008 All Rights Reserved.


“Summary
Global spending in the domain is being driven by the increasing frequency of terror attacks that have taken place in the last couple of years and the associated fear of knowing that non-state as well as organized actors are in all probability active within the country and possess acute local knowledge which might enable some of these elements to strike at critically important networks, sites or processes successfully
Key Findings
– The Critical Infrastructure Protection (CIP) market is expected to value US$64.6 billion in 2016, and grow at a CAGR of 2.44% to value US$82.2 billion by 2026. The cumulative market for global expenditure on CIP is expected at US$813.6 billion over the forecast period
– The CIP market is expected to be lead by North America with an expected share of 34.6% over the forecast period, followed by the Asia Pacific region at 27.4%, and Europe at 25%. The Middle Eastern market for CIP is expected to account for a share of 10.9%, followed by the Latin American and African markets with a cumulative share of 2.2%
– Over the forecast period, the Physical Security segment is expected to account for 69.9% of the market., while Network Security and the Others segments (includes investment in ancillary and support activities) are expected to account for shares of 27.1% and 3% respectively
Synopsis
The Global CIP Market 2016-2026 report offers a detailed analysis of the industry with market size forecasts covering the next ten years. This report will also analyze factors that influence demand for CIP equipment, systems and services, key market trends, and challenges faced by industry participants. In particular, it provides an in-depth analysis of the following:
– Market size and drivers: detailed analysis during 2015-2025, including highlights of the demand drivers and growth stimulators. It also provides a snapshot of the spending and modernization patterns of different regions around the world.
– Recent developments and industry challenges: insights into technological developments and a detailed analysis of the changing preferences of CIP segments around the world. It also provides trends of the changing industry structure and the challenges faced by industry participants.
– Regional highlights: study of the key markets in each region, providing an analysis of the key segments of the market that are expected to be in demand.
– Major programs: details of the key programs in each segment, which are expected to be executed during 2015-2025.
– Competitive landscape and strategic insights: analysis of the competitive landscape of the global market. It provides an overview of key players, together with information regarding key alliances, strategic initiatives, and financial analysis.
Reasons To Buy
– Determine prospective investment areas based on a detailed trend analysis of the global CIP market over the next ten years.
– Gain in-depth understanding about the underlying factors driving demand for different CIP segments in the top spending countries across the world and identify the opportunities offered by each of them.
– Strengthen your understandingof the market in terms of demand drivers, SWOT, industry trends, and the latest technological developments, among others.
– Identify the major channels that are driving the global CIP market, providing a clear picture about future opportunities that can be tapped, resulting in revenue expansion.
– Channelize resources by focusing on the ongoing programs that are being undertaken by the internal ministries of different countries within the CIP market.
– Make correct business decisions based on thorough analysis of the total competitive landscape of the sector with detailed profiles of the top CIP suppliers around the world which include information about their products, alliances, recent contract wins and financial analysis wherever available.”


Inclusion Criteria:
- Histologically documented pancreatic adenocarcinoma not previously treated with
systemic therapy.
- Complete macroscopic and microscopic (R0) resection for ductal adenocarcinoma of the
pancreas with no evidence of malignant ascites, peritoneal metastases or distant
metastases. Lack of recurrent and/metastatic disease must be confirmed
radiologically with CT chest, abdomen, and pelvis prior to enrolment.
- Adequate tissue available for IHC testing of hENT1. Histological/cytological
confirmation of tissue to ensure sufficient material is available for hENT1 analysis
by the Cross Cancer Institute (CCI) is required. Paraffin block sufficient for
preparing ≥ 6 unstained slides for central storage and testing if required by
oncologist.
- ECOG performance status of 0 - 2. (Appendix B)
- Age ≥ 18 years
- Life expectancy of at least 6 months based on discretion of treating
- Adequate hematologic function defined by the following laboratory parameters:
Hemoglobin > 100, Platelet count > 100 and Absolute granulocyte count > 1.5.
- Adequate hepatic and renal function defined by the following laboratory parameters:
AST and ALT ≤ 2.5 X upper limit of institutional normal, bilirubin ≤ upper limit of
institutional normal, and calculated creatinine clearance of ≥ 50 mL/min using the
Cockcroft-Gault formula, if just below 50 mL/min based on this formula then GFR ≥ 50
mL/min as determined.
- Patients may have received prior curative radiotherapy for a different malignancy
(unless radiation was curative therapy to ≥ 25% of bone marrow stores) and patients
must have recovered from the toxic effects of this treatment.
- Patients must be started on protocol ≤ 10 weeks from the date of curative surgical
resection, and patients must have recovered from the toxic effects of surgery.
- Patients must have the ability to read, understand, and sign an informed consent and
must be willing to comply with study treatment and follow-up.
Exclusion Criteria:
- Patients who have received prior chemotherapy or radiation delivered as parts of
initial curative therapy for pancreas cancer (i.e. neoadjuvant or adjuvant
chemotherapy administered alone and/or concurrently delivered with radiation and/or
surgery) are not permitted. Metastatic patients are not permitted.
- Prior treatment for a different malignancy with > 6 cycles of traditional alkylating
agent-based chemotherapy, > 2 cycles of carboplatin-based chemotherapy, or concurrent
treatment with other experimental drugs or anti-cancer therapy.
- Lack of physical integrity of the upper gastrointestinal tract, malabsorption
syndrome, short gut syndrome, or history of bowel obstruction due to peritoneal
metastases.
- Previous or concurrent malignancies, excluding curatively treated in situ carcinoma
of the cervix or non-melanoma skin cancer, unless at least 5 years have elapsed since
last treatment and the patient is considered cured.
- Any serious medical condition within 6 months prior to study entry such as myocardial
infarction, uncontrolled congestive heart failure, unstable angina, active
cardiomyopathy, unstable ventricular arrhythmia, cerebrovascular diseases,
uncontrolled hypertension, uncontrolled diabetes, uncontrolled psychiatric disorder,
serious infection, active peptic ulcer disease, or other medical condition that.
- Known dihydropyrimidine dehydrogenase (DPD) deficiency.
- Pregnant or lactating women; women of child bearing potential must have a negative
serum pregnancy test within 7 days of trial registration. Women or men of child
bearing potential must use effective contraception (defined by the treating
physician) which must be documented in study CRFs.
- Any other reason the investigator considers the patient should not participate in the
study


The Patent Trial and Appeal Board (PTAB) recently denied Patent Owner’s counsel’s motion to withdraw from representation of Patent Owner in
Shire Dev. LLC v. LCS Group LLC, IPR2014-00739 (Nov. 21, 2014) (Paper 9). Under 37 C.F.R. § 42.10(e), counsel may not withdraw without PTAB authorization. The Shire Dev. request was denied because the inventor could not proceed pro se as the patent was assigned to LCS Group, LLC, which was also designated as the real party-in-interest.
The PTAB followed the general rule presented in
Motorola Mobility, LLC v. Arnouse, IPR2013-00010 (March 21, 2013, Paper 24) (April 19, 2013, Paper 30), that a juristic entity, e.g., a corporate entity, may not represent itself pro se in a proceeding before the PTAB. The panel in Motorola Mobilityrelied on Talisila, Inc. v. United States, 240 F.3d 1064, 1066 (Fed. Cir. 2001) and 37 C.F.R. § 1.31 (2012). Paper 24 at 3; Paper 30 at 6-7. Notably, neither addresses representation of a patentee or a petitioner before an agency. Tasila concerns whether a corporation may represent itself pro se in , such as the Court of Federal Claims. Rule 1.31 concerns who may represent an federal courts for a patent, noting that juristic entities must be represented by a patent practitioner. applicant
As in
Shire Dev., the issue of pro se representation typically arises in the context of a motion to withdraw by patent owner’s counsel. Authorization to proceed pro se depends on whether the party or real party-in-interest is a juristic entity. For example in United States v. Golden, IPR2014-00714, the PTAB authorized Mr. Golden to file a motion to proceed pro se because the record showed that he, “in his personal capacity,” was the Patent Owner. Paper 17 at 2. In contrast, in Motorola Mobility, the PTAB noted that while the power of attorney and mandatory notices identified Mr. Arnouse as the patent owner and sole real party-in-interest, a Complaint from a copending litigation stated that Arnouse Digitial Devices Corp (ADD) was the exclusive licensee with “all substantial rights.” Paper 30 at 2-3. As ADD appeared to be the “effective patentee,” Mr. Arnouse could not proceed pro se. Id. at 7. With respect to Shire Dev., the PTAB noted that the mandatory notices identified LCS Group, a juristic entity as the patent owner and real party-in-interest; not the inventor.Paper 9 at 2. Further, this would not necessarily be corrected by assigning ownership back to the inventor, particularly where “any rights” may remain in the juristic entity. Id. The inventor may become the patent power but the juristic entity remains a real party-in-interest. Id.
Even if the motion to proceed
pro se is authorized, the PTAB highly advises the party to retain counsel, explaining that “given the complexity and very technical nature of these proceedings, pro se representation carries significant risk.” Golden, Paper 17 at 2.


Published on
Static Business and Strategic Plans are fast becoming irrelevant in a world of rapid commoditization, great uncertainty, and limited resources especially for scalable startups. BUSINESS MODEL DEVELOPMENT (BMD) is emerging as a more dynamic, relevant, and cost-effective approach. However, tools for BMD are authored by different people and found in different books as well as websites. Finding a comprehensive set of tools for BMD is time-consuming.
This presentation, "Business Model Development for Blue Ocean Startups" is currently the only resource that integrates tools for BMD in a worksheet or template format that facilitates collaboration. The tools can instantly be used for your projects on business model discovery, validation, execution, and/or performance management. Please note that this FREE & INTERACTIVE One-stop Toolkit is available for a LIMITED TIME.


The Role of Trace Minerals in Dairy Hoof Health
Trace mineral nutrition plays a critical role in building and maintaining strong, healthy feet. For example, zinc and copper are essential nutrients for developing healthy claw horn tissue, while zinc and manganese play a crucial role in wound healing. Research has shown that feeding a combination of trace minerals (Zn, Mn, Cu and Co) in a highly available complexed form helps decrease both the incidence and severity of common claw lesions.


Abstract
Abstract Neurons in the rostral ventrolateral medulla (RVLM) are involved in both tonic and reflex control of sympathetic outflow. Many of these neurons express the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT), and are designated C1 neurons. C1 neurons that contain mu-opioid receptors (MORs) are hyperpolarized by MOR activation and are activated during morphine withdrawal. The present study examined the subcellular distribution of the cloned MOR, MOR1, in rat C1 neurons following chronic morphine treatment, using RVLM sections that were dually labeled for PNMT-immunoperoxidase and MOR1-immunogold. Electron microscopic analysis of the subcellular distribution of MOR1 revealed a lower abundance of plasma membrane-associated MOR1 in C1 dendrites of rats treated with morphine, compared to placebo-treated controls, only in distal dendrites. There were no differences in the size of dual-labeled dendrites between treatment groups or in the overall density of MOR1 within PNMT immunoreactive dendrites between treatment groups. These results suggest that chronic morphine treatment leads to a decreased presence of MOR1 at the cell surface, without a significant reduction in cytoplasmic receptor density. These observations suggest that chronic morphine produces a selective internalization of MOR1 in C1 neurons, without apparent changes in receptor synthesis or trafficking. The reduction of accessible MORs on these neurons may be a mechanism for tolerance with regard to autonomic responses to opioid administration and may facilitate the profound sympathetic hyperactivity that occurs during acute opioid withdrawal.


Autosomal dominant myotonia congenita (Thomsen's disease) is caused by mutations in the muscle chloride channel CIC-1. Several point mutations found in affected families (I29OM, R317Q, P480L, and Q552R) dramatically shift gating to positive voltages in mutant/WT heterooligomeric channels, and when measurable, even more so in mutant homooligomers. These channels can no longer contribute to the repolarization of action potentials, fully explaining why they cause dominant myotonia. Most replacements of the isoleucine at position 290 shift gating toward positive voltages. Mutant/WT heterooligomers can be partially activated by repetitive depolarizations, suggesting a role in shortening myotonic runs. Remarkably, a human mutation affecting an adjacent residue (E291K) is fully recessive. Large shifts in the voltage dependence of gating may be common to many mutations in dominant myotonia congenita.


Recent decades have seen rapid advances in automatization processes, supported by modern machines and computers. The result is significant increases in system complexity and state changes, information sources, the need for faster data handling and the integration of environmental influences. Intelligent systems, equipped with a taxonomy of data-driven system identification and machine learning algorithms, can handle these problems partially. Conventional learning algorithms in a batch off-line setting fail whenever dynamic changes of the process appear due to non-stationary environments and external influences. Learning in Non-Stationary Environments: Methods and Applications offers a wide-ranging, comprehensive review of recent developments and important methodologies in the field. The coverage focuses on dynamic learning in unsupervised problems, dynamic learning in supervised classification and dynamic learning in supervised regression problems. A later section is dedicated to applications in which dynamic learning methods serve as keystones for achieving models with high accuracy. Rather than rely on a mathematical theorem/proof style, the editors highlight numerous figures, tables, examples and applications, together with their explanations. This approach offers a useful basis for further investigation and fresh ideas and motivates and inspires newcomers to explore this promising and still emerging field of research.


This paper describes a processing approach which enables perceptually compelling modification of audio signals via accentuation or suppression of transients. The transient detection uses a frequency-domain analysis which yields a spectral. ux parameter. In typical detection methods, such a parameter would be compared with a threshold to derive a binary transient detection function. Here, we instead use an adjustable graded response to arrive at a continuous transient characterization function. This smooth function is used to drive a nonlinear frequency-domain signal modification. We demonstrate that binary detection is problematic for perceptual manipulation, that our approach overcomes these problems, and that our system is able to achieve substantial modification of a signal's perceptual attributes without introducing significant artifacts.
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This book relates the history of
asteroid discoveries and christenings, from those of the early pioneering giants of Hersehel and Piazzi to modern-day amateurs. Moving from history and anecdotal information to science, the book's structure is provided by the names of the asteroids, including one named after the author.
Free from a need to conform to
scientific naming conventions, the names evidence hero-worship, sycophancy, avarice, vanity, whimsy, erudition and wit, revealing the human side of astronomers, especially where controversy has followed the christening. Murdin draws from extensive historical records to explore the debate over these names. Each age reveals its own biases and preferences in the naming process.
Originally regarded as "vermin of
the skies," asteroids are minor planets, rocky scraps left over from the formation of the larger planets, or broken fragments of worlds that have collided. Their scientific classification as "minor" planets makes them seem unimportant, but over the past decades asteroids have been acknowledged to be key players in the Solar System. This view of their starring role even alters the trajectories of spacecraft: NASA's policy for new space missions en route to the outer planets is that they must divert to study passing asteroids whenever possible. This book provides for readers a complete tour of the fascinating world of asteroids.
Paul Murdin is a distinguished internationally
known astronomer with a track record of well-written books and eloquent lectures about astronomy. He has been honored with an OBE in 1988, the Award of the Royal Astronomical Society for Services to [professional] Astronomy in 2011, the Eric Zucker Award of the Federation of Astronomical Societies for outreach to amateur astronomers, in 2012, and the name of asteroid 128562 Murdin.
Einband gebundene Ausgabe Seitenzahl 207 Erscheinungsdatum 27.07.2016 Sprache Englisch ISBN 978-3-319-31835-6 Reihe Springer Praxis Books / Space Exploration
Verlag Springer Maße (L/B/H) 287/217/17 mm Gewicht 809 Abbildungen 5 schwarz-weiße und 45 farbige Abbildungen, Bibliographie Auflage 1st ed. 2016


The dynamics of self-confidence are modelled in an environment where rational individuals optimally choose educations and occupations with the aim to acquire productive skills while learning about ability. It is shown how the presence of uninformative options can trap individuals below their potential. Furthermore, the trade-off between probability of success and value of skills may induce uncertain individuals to acquire less productive skills on their way to ability intensive occupations. The value of information also induces uncertain individuals to delay their labor market entry. The model can explain differences in perseverance in the face of failure.


The overall five-year survival rate for people diagnosed with a malignant gastrointestinal stromal tumor, based on data obtained between 2003 and 2009, is approximately 76 percent, according to the American Cancer Society. This data is the best available for determining a survival rate for this type of tumor.Continue Reading
A five-year survival rate is the percentage of people with a disease who survive at least five years following diagnosis, states the American Cancer Society. This rate is what doctors use to discuss a prognosis, but many people survive longer than five years. Per the 2003 to 2009 data, if the GIST has not spread further than one organ at the time of diagnosis, the five-year survival rate is 91 percent. If it has spread to distant parts of the body, the five-year survival rate drops to 48 percent.Learn more about Conditions & Diseases


Primary languages are to be an entitlement for all pupils in KS2 from 2010. There is therefore a need to ensure that trainee primary teachers are equipped with the required skills, knowledge and understanding to contribute to this process. This book supports specialists, and also non-specialist trainees with an interest in MFL, who may need to deliver languages across the curriculum, providing them with a clear understanding of the methodology and helping them to develop linguistic competence and confidence.


ABSTRACT
Calcrete-coated remnants of landslide debris and alluvial deposits are exposed along the presently stable hillslopes of the Soreq drainage, Judea Hills, Israel. These remnants indicate that a transition from landslide-dominated terrain to dissolution-controlled hillslope erosion had occurred. This transition possibly occurred due to the significant decrease in tectonic uplift during the late Cenozoic. The study area is characterized by sub-humid Mediterranean climate. The drainage hillslopes are typically mantled by thick calcrete crusts overlying Upper Cretaceous marine carbonate rocks. Using TT-OSL dating of aeolian quartz grains incorporated in the calcrete which cements an ancient landslide deposit, we conclude that incision of ~100 m occurred from 1056 ± 262 to 688 ± 86 ka due to ~0·3° westward tilt of the region; such incision invoked high frequency of landslide activity in the drainage. The ages of a younger landslide remnant, alluvial terrace, and alluvial fan, all situated only a few meters above the present level of the active streambed, range between 688 ± 86 ka and 244 ± 25 ka and indicate that since 688 ± 86 the Soreq base level had stabilized and that landslide activity decreased significantly by the middle Pleistocene. Copyright © 2012 John Wiley & Sons, Ltd.


Admission of guilt fines are now applicable to certain specified offences under the Waste Act. The maximum fine is R5, 0000.
The Regulations only apply to general waste and not hazardous or priority waste, as defined under the Waste Act.
Whilst general waste has less environmental impacts than hazardous waste, it is likely that these Regulations will be severely criticized by environmental groups as the maximum admission of guilt fine is extremely low, particularly when compared to other fines under the Waste Act and does not provide any significant deterrent.


Effective and sustainable teambuilding is necessary in today's marketplace where fewer people are being required to do more work. More often than not, the adage "Getting everyone rowing in the same direction" is associated with building effective teams. However, is this really true? If everyone is rowing in the same ...Download Now


30 months in, the conflict in Syria has invited more guns than expected. Starting off with a group of breakaway officers who formed the armed rebel core of the Free Syrian Army, Syria is now cursed with a number of auxiliary groups engaging in combat alongside both the government and opposition forces.
The Assad regime seeks the support of the Lebanese group of Hezbollah and the Iraqi group Abu Fadl Al-Abbas Brigade in combat. Their scored victory in the battles of Al-Qusayr stands witness to the effectiveness of Hezbollah in unconventional warfare in unpredictable terrain. The coordinated strategies of Syrian President Bashar al-Assad's groups in combat pose a sharp contrast to the disoriented and deeply fragmented armed opposition, let alone the political wing of the Syrian opposition.
Aron Lund notes the divisions of the Syrian armed opposition into three main groups: the Free Syrian Army, the Syrian Islamic Front, and the Syrian Islamic Liberation Front. Under the aegis of these groups operate dozens of sub-groups with different ideological orientations, diverging external agendas, diverse sources of funding, and a burgeoning membership base of foreign fighters.
Unlike Hezbollah, which risks losing a vital supply lifeline and political sponsor with the demise of the Assad regime, the foreign opposition fighters identify with radical elements within the Syrian opposition on a narrow sectarian basis. The Syrian cocktail of foreign groups to buttress the regime and opposition fighters alike helps imbue the Syrian conflict with the sectarian die that plagues the region, notably the Sunni-Shiia divide. It is through this framework that the Syrian conflict threatens to debunk the security conditions of neighboring states such as Lebanon, Iraq, and possibly Turkey.
But the key to any potential solution in Syria lies with the Cold War players: the USA and Russia. The media and diplomatic role the USA and Russia played in their divergent interpretations of a reported chemical attack in a Damascus suburb on August 21 contained the seeds for a potential showdown in Syria, with U.S. and Russian fleets floating on Mediterranean waters. Compound this with the preparedness of Iran and Israel to enter the war alongside their allies.
The recent U.S.-Russian deal averts a potential U.S. strike by placing Syrian chemical weapons under international auspices but does not unambiguously indicate an end to Syria's civil war. But it does provide a political vent that the U.S. and Russia could build upon to broker a peace treaty in Syria. The forthcoming months will reveal whether the USA and Russia can summon the world to implement their Syrian roadmap or whether regional spoilers such as the EU, GCC, Iran, Turkey and Israel will continue to fish for their interests in Syria.
Any peaceful solution to the Syrian conflict ought to include a power-sharing agreement involving Assad loyalists and opposition figures in a transitional government. The transitional government ought to work on restoring the peace by promoting the disarmament and demobilization of armed groups, and their subsequent reintegration into the Syrian state and society. These steps should take place under close international auspices to insure genuine implementation of the agreement. Preparing for transparent parliamentary and presidential elections, reconstructing destroyed cities, and repairing damaged infrastructure should also be prioritized on the agenda of post-war governments.
Seeing that the political fog prevents a clear view of such reforms, the Syrian people are likely to be still counting in months and placing their bets on a comprehensive U.S.-Russian deal.


Helicobacter spp. represent a proportionately small but significant component of the normal intestinal microflora of animal hosts. Several of these intestinal Helicobacter spp. are known to induce colitis in mouse models, yet the mechanisms by which these bacteria induce intestinal inflammation are poorly understood. To address this question, we performed… (More)


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