Engineers in Action/Women in Engineering: Alicia Martin
“I have learned to use the word “impossible” with the greatest caution.” Wernher von Braun
Many dream of the opportunity to spend their days in a powersports shop, refining their riding skills on homemade corner tracks, and regularly travelling to renowned snowmobile and motocross destinations across the western United States. For mechanical engineering graduate student Alicia Martin this has been her entire life. A drive for pushing boundaries, surmounting obstacles, and pursuing what lies beyond the next horizon is engrained in her spirit.
Growing up in Evanston, WY, Alicia’s father was the owner of Mountain Air Power and Sports, a regional western Wyoming hub for the powersports industry. Alicia and her brother grew up competing in snocross and hill climb events in the Mountain West Racing (MWR) circuit, an affiliate of the International Series of Champions (ISOC). This culture provided a natural inclination towards an interest in powersports and engineering.
Alicia began her education at UW as a BS in Mechanical Engineering student. During this time, she was awarded numerous scholarships that have funded her education, including; the Hathaway Scholarship, the Samuel C. Phillips Memorial Scholarship, the Dr. Dwight W. Senser Mechanical Engineering Scholarship, the Joe and Arlene Watt Scholarship honoring H.T. Person, the PacifiCorp Scholarship, and the Rocky Mountain Power Scholarship.
Alicia also participated in multiple CEAS student societies, including; member of the Tau Beta Pi Engineering Honors Society 2009-present, Treasurer for the Society of Automotive Engineers 2008-2011, and member of the Society of Mechanical Engineers 2008-present.
Prior to graduation, Alicia participated in two summer internships with British Petroleum (BP), gaining valuable energy industry-related experience. She spent the summer of 2009 working at BP’s Painter Complex located just north of Evanston, WY. Throughout the summer Alicia provided day-to-day engineering support, while also performing structural, piping, and compressor analysis. In 2010, she was asked to take a second internship with BP at their Houston, TX facilities. In Houston, Alicia provided engineering support for the maintenance and reliability of rotating equipment, while also supporting BP sites across the United States providing structural, compressor, and procurement analysis.
These internships gave Alicia insight into the operational channels that exist within these plants including an understanding of their functions in a real-time environment. Graduating with a BS in Mechanical Engineering, she was offered a lucrative full-time position at BP America. She chose to remain at UW to continue her education toward a MS in Mechanical Engineering under the mentorship of Dr. Carl Frick.
Alicia is currently working in the Advanced Materials Lab, part of the Mechanical Engineering Department. Her research activities involve characterizing new materials for use in emerging technologies, with a focus on developing and characterizing “active materials” that have the ability to respond to certain prescribed stimuli. Alicia is studying a polymer matrix composite with multi-walled carbon nanotubes as reinforcement. The goal of this research is to induce an amorphous-to-crystalline transition of the composite via resistive heating when an electric current is applied.
Alicia has been named a Graduate Fellow in the Science Posse and will continue working with this organization through the summer of 2013. The Science Posse comprises a group of graduate students in STEM (science, technology, engineering, and mathematics) fields that share a passion for science and education. They regularly travel throughout Wyoming sharing their knowledge with middle and high school students, providing unique, enriching educational experiences. They also host annual workshops for teachers of grades 5-12 to enhance their experience with science and engineering topics.
After completion of her MS degree in the spring of 2013, Alicia intends to pursue employment within the powersports industry. Embodying the knowledge and intellect required to engineer the complex systems associated with these sports, while simultaneously understanding the dynamics of these sports from the athlete’s perspective, provides her with the skill set sought after in this highly competitive industry. Consistently demonstrating a fearless and unyielding determination, Alicia has established herself as a role model for current and future generations of women engineers.


English français Double-diffusive convection in Lake Kivu
Double-diffusive staircases with a total of 230-350 mixed layers and sharp interfaces were observed in nine microstructure temperature profiles measured during February 2004 in Lake Kivu. The presence of these staircases at depths. 120 m indicates that diapycnal turbulent mixing is weak and vertical diffusive transport is dominated by double diffusion. Contrary to previously investigated natural or laboratory double-diffusive systems, the dissolved gases CO(2) and CH(4) contribute significantly to the density stratification, thereby influencing the formation and the structure of the staircases. The density ratio (i.e., the ratio of the stabilizing effect of dissolved substances to the destabilizing effect of temperature) ranges between 2.0 and 4.5 in large sections of the deep waters, implying a high susceptibility to the formation of staircases. The mixed layers (average thickness 0.48 m) are shown to be in a state of active convection. The average thickness of the interfaces (0.18 m) is surprisingly constant and independent of the large-scale stratification. The vertical heat fluxes correlate well with the temperature steps across the interfaces. Lake Kivu receives inflows from subaquatic springs at several depths that maintain the large-scale structure of the density stratification and disturb the staircases. In comparison to earlier observations from 1972, the double-diffusive heat fluxes appear to have been reduced, leading to a heat accumulation in the deep waters. Conversely, the strengthening of the main chemocline indicates an increased discharge of the subaquatic springs that could be responsible for recent changes in the nutrient cycling and methane production in the lake.


The protein products of several rad checkpoint genes of Schizosaccharomyces pombe (rad1+, rad3+, rad9+, rad17+, rad26+, and hus1+) play crucial roles in sensing changes in DNA structure, and several function in the maintenance of telomeres. When the mammalian homologue of S. pombe Rad9 was inactivated, increases in chromosome end-to-end associations and frequency of telomere loss were observed. This telomere instability correlated with enhanced S- and G2-phase-specific cell killing, delayed kinetics of gamma-H2AX focus appearance and disappearance, and reduced chromosomal repair after ionizing radiation (IR) exposure, suggesting that Rad9 plays a role in cell cycle phase-specific DNA damage repair. Furthermore, mammalian Rad9 interacted with Rad51, and inactivation of mammalian Rad9 also resulted in decreased homologous recombinational (HR) repair, which occurs predominantly in the S and G2 phases of the cell cycle. Together, these findings provide evidence of roles for mammalian Rad9 in telomere stability and HR repair as a mechanism for promoting cell survival after IR exposure.


Description "After the Deluge" offers a new, provocative interpretation of Russia's struggle in the 1990s to construct a democratic system of government in the largest and most geographically divided country in the world. The Russian Federation that emerged from the Soviet Union faced dissolution as the leaders of Russia's constituent units in the early 1990s defied Moscow's authority, declared sovereign states on their territory, refused to remit taxes, and even adopted national constitutions, flags, and anthems.Yet, by mid-decade, a fragile equilibrium had emerged out of the apparently chaotic brinkmanship of central and regional officials. Based on extensive statistical analysis of previously unpublished data as well as interviews with numerous central and regional policymakers, "After the Deluge" suggests an original and counterintuitive interpretation of this experience.In most cases, confrontations between regions and Moscow constituted a functional kind of drama. Regional leaders signaled just how much they were willing to risk to secure particular benefits. With a policy of "selective fiscal appeasement," federal officials directed subsidies, tax breaks, and other benefits to the most protest-prone regions, which in turn engendered a shift in local public opinion. By buying off potential regional dissenters, Moscow halted what might have become an accelerating bandwagon.Besides offering insight into Russia's emerging politics, "After the Deluge" suggests a range of parallels to other cases of territorially divided states and empires--from contemporary China to Ottoman Turkey. It should appeal to a broad audience of scholars in political science, economics, history, geography, and policy studies.Daniel S. Treisman is Assistant Professor of Political Science, University of California, Los Angeles.


A new version of
Odyne System’s plug-in hybrid propulsion package for heavy-duty utility bucket trucks significantly reduces both the weight and cost of the overall unit, potentially helping improve its payback calculation position in the market.
During a press conference at the 2012
National Truck Equipment Assn. (NTEA) show in Indianapolis, Matt Jarmuz, Odyne’s director of sales, noted that company recently switched to using a lithium-ion battery pack for its technology package, versus far heavier and shorter lifecycle lead-acid batteries previously used to power the product.
As a result of using lighter yet more powerful lithium-ion batteries, Jarmuz told
Fleet Owner that the company reduced the total weight of its hybrid package from 4,000 lbs. to 1,600 lbs., while cutting the cost of the entire system from near $100,000 down to approximately $50,000.
“That weight and cost reduction is helping us get closer to the five-year payback target we’re aiming at,” he explained. “We expect to achieve payback not just from a 50% reduction in fuel consumption due to less engine idling, but also through less maintenance for the engine resulting less hours of operation, longer oil drain intervals, etc.”
Odyne’s plug-in hybrid pack allows utility truck crews to operate the vehicle’s air conditioning and heating systems while the engine is off at the job site. The technology also provides “launch assist” to reduce engine loads during acceleration, climbing and turning. Odyne’s product also uses regenerative braking to help recharge the batteries during drive cycles, along with plug-in recharging capability to again reduce the need to operate the truck’s main engine.
Jarmuz noted that several utility fleets are now testing five trucks mounted its improved hybrid package mounted via grants from the
U.S. Dept. of Energy, including: Consumers Energy of Michigan, the principal subsidiary of CMS Energy; Choptank Electric Cooperative in Maryland; NiSource, a utility in Northern Indiana;Pepco Holdings Inc., which serves about 1.9 million customers in Delaware, the District of Columbia, Maryland and New Jersey; and NV Energy in Reno, NV.


Feeding both Halo canned and dry formulas
We recommend that pets eat a combination of dry and canned food every day. Their bodies are made of 75% water. Some pets rarely drink enough water to support excellent hydration and organ function so we recommend at least 25% of a pet’s daily calories come from canned food.
Should you want to mix Halo wet and dry food for your pet daily or occasionally, below are suggestions for balanced proportions providing extra hydration and variety without over feeding.
Dog: How to replace ¼ cup dry with wet Cat: How to replace ¼ cup dry with wet Note: Feeding both dry and canned Halo formulations is not necessary to meet a pet’s daily nutritional needs. This recommendation represents Halo’s feeding preference for optimal pet health.


They set ambitious targets and consistently and continuously achieve those objectives. They display a strong sense of purpose through shared values both inside (among employees) and outside the organization (among customers, suppliers, and other stakeholders). They have a strategic focus and alignment so that employees know how they are contributing to the results of the organization. They have the agility to adapt to changing circumstances quickly. And, finally, they have a common and shared business model throughout the organization. Emulating these organizations requires a focus on performance management. The journey toward becoming a high-performance organization is never-ending, and it's full of pitfalls and detours. Still, every step along the way is worthwhile because it improves the company in some manner. For the HPO, the journey is the destination. BOTTOMLINE:


1. Whyte, Michael P: 17 articles (06/2015 - 06/2006) 2. Millán, José Luis: 13 articles (12/2015 - 06/2008) 3. Mumm, Steven: 12 articles (06/2015 - 06/2006) 4. Narisawa, Sonoko: 6 articles (12/2015 - 06/2008) 5. Shimada, Takashi: 6 articles (12/2015 - 01/2011) 6. Mornet, Etienne: 6 articles (11/2015 - 01/2009) 7. Coburn, Stephen P: 6 articles (06/2015 - 08/2007) 8. Oda, Kimimitsu: 5 articles (08/2015 - 04/2012) 9. Sohda, Miwa: 5 articles (08/2015 - 04/2012) 10. Wenkert, Deborah: 5 articles (06/2015 - 08/2007)
1. Cysts
03/10/2011 - "Nothing is known on the efficacy of HPP on tapeworm cysts or eggs. "
02/01/2006 - "In this study, we examined the effects of high-pressure processing (HPP) on ground pork containing viable tissue cysts of the VEG strain of T. "
02/01/2006 - "Results indicate that HPP treatment of ground pork with 300 MPa of pressure will render tissue cysts of T. "
02/01/2006 - "Ground pork containing tissue cysts was exposed to 400, 300, 200, 100, or 0 MPa treatment for 30, 60, or 90 sec in a commercial HPP unit. "
09/01/1989 - "Microscopic examination revealed mucosal cysts (MC), focal foveolar hyperplasia (FFH), and hyperplastic polyp (HPP). "
2. Craniosynostoses (Craniosynostosis)
05/01/2015 - "The authors discuss their case series of 4 HPP patients treated at their institution with ERT who have undergone successful surgical intervention for craniosynostosis. "
05/01/2015 - "Traditionally, HPP has had a poor prognosis, with few children surviving to exhibit the phenotype of clinical craniosynostosis that requires surgical intervention. "
05/01/2015 - "Patients with HPP have defective bone mineralization as well as craniosynostosis that can be seen in the infantile and childhood forms of this disease. "
01/01/2015 - "These results are very promising especially with regard to the skeletal phenotype but it is unclear whether ERT also has beneficial effects for craniosynostosis and in other affected tissues in HPP such as brain and kidney. "
10/01/2014 - "These findings demonstrate that Alpl(-/-) mice exhibit a craniofacial skeletal phenotype similar to that seen in infants with HPP, including true bony craniosynostosis in the context of severely diminished bone mineralization. "
3. Hypertension (High Blood Pressure)
03/24/2015 - "AASI, 24 hPP, sleeptime relative SBP decline and 24 hSBP are the most significant ambulatory blood pressure-related parameters in predicting renal impairment in resistant hypertension."
12/01/2013 - "He manifested HPP in childhood and in middle age received hemodialysis for CRF attributed to hypertension and anti-inflammatory medication. "
11/01/2012 - "For Chr 18, selected for the Russian part of C-HPP, about 25% of the encoded genes were associated with diseases, including cancers and neurodegenerative and psychiatric diseases, as well as type 1 diabetes and essential hypertension. "
11/01/1990 - "Monotherapy with HPP proved beneficial in affection of 1-2 joints whereas the baths appeared preferable in polyosteoarthrosis, its association with spinal osteoarthrosis, arterial hypertension. "
4. Adenocarcinoma
06/01/1983 - "Consequently, the effect of Hx and HPP on the metabolism of [6-3H]-FUra was examined in 5 human colorectal adenocarcinomas maintained as xenografts in immune-deprived mice. "
01/01/2008 - "Immunohistochemistry and Western blot is used to analyse HIF-1alpha expression in normal colonic mucosa, hyperplastic polyps (HPP), sessile serrated adenomas (SSA), low-grade (TA-LGD) and high-grade (TA-HGD) traditional adenomas as well as in non-metastatic and metastatic colorectal adenocarcinomas. "
08/22/1996 - "The same concentration of antagonist abolished responses to PYY and [Leu31,Pro34]NPY but had no effect upon human pancreatic polypeptide (hPP) in monolayer cultures of the human adenocarcinoma cell line, Colony-6. Schild analysis of BIBP3226 antagonism of PYY responses in Colony-6 cells provided a pA2 value of 7.9 with a Hill slope of 1.03, indicating competitive antagonism at these epithelial Y1 receptors."
05/01/1982 - "A series of four human colon adenocarcinomas, growing as xenografts in immune-deprived mice, have been used to evaluate the efficacy of 5-FU in combination with two purines, hypoxanthine (Hx) and allopurinol (HPP), which have reduced the toxicity of 5-FU in host mice. "
5. Congenital Abnormalities (Deformity)
09/01/2008 - "A boy with HPP showing long bone deformity that spontaneously improved in utero and after birth is described. "
09/01/2008 - "The patient is an autosomal recessive case of HPP with prenatal long bone deformity but with spontaneous prenatal and postnatal improvement. "
09/01/2008 - "Our objective was to identify TNSALP mutations and characterize the inheritance pattern of a family with clinically variable HPP with one child manifesting in utero with long bone deformity but showing spontaneous prenatal and postnatal improvement. "
11/28/1997 - "BPP displayed the highest frequency of associated congenital defects (23.4%, vs HPP:6.6%, FPP: 15.4%). "
10/01/2011 - "Clinical features of HPP include defective bone mineralisation with bone deformities, fractures and chronic non-bacterial osteomyelitis. "
1. Allopurinol (Remid) 2. Fluorouracil (Carac) 3. Melphalan (Alkeran) 4. Hypoxanthine 5. 1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium) 6. Vitamin E 7. Purines 8. Procarbazine (Matulane) 9. Prednisolone (Predate) 10. Hydrogen Peroxide (Hydroperoxide)
1. Heterologous Transplantation (Xenotransplantation) 2. Combination Drug Therapy (Combination Chemotherapy) 3. Baths 4. Laparoscopic Cholecystectomy 5. Enzyme Replacement Therapy


Study Shows Actors Struggle to Resolve Emotional Problems
A new study shows that actors are more likely to struggle with dealing with past traumas, and that they might find it harder to resolve emotional difficulties.
The study, conducted by researchers at California State University, revealed that “there is a psychological cost for participants engaged in the creative arts.” The researchers also noted that “more actors were unable to maintain narrative coherence when discussing memories of past trauma and loss.”
In an article by
The Guardian, researchers Paula Thomson and S. Victoria Jaque said that actors are more likely to “display signs of confusion, prolonged silence or unsuccessful failures to deny a traumatic or loss event.” They believe this indicates a greater vulnerability for psychological distress.
The good news? Actors have “higher than usual imaginative facilities than members of the control group.” Thomson and Jaque said, “Actors may have enhanced their imagination through the practice of acting or they may have entered a career that supports their heightened predisposition for fantasy.”


Federal Reserve policymakers appear less keen to launch a fresh round of monetary stimulus as the U.S. economy improves, according to minutes for the central bank's March meeting.
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The Fed policymakers noted recent signs of slightly stronger growth but remained cautious about a broad pick up in U.S. economic activity, focusing heavily on a still elevated jobless rate.
However, the minutes suggest the appetite for another dose of quantitative easing, so-called QE3, has waned significantly.
The March meeting minutes noted "a couple" of members thought additional stimulus might be needed if the economy loses momentum or inflation remains too low for too long.
That contrasted with a much broader characterization in January, when the minutes cited a few members as seeing a possible need for additional easing before long, and others thinking stimulus might be required if economic conditions worsened.
Still, the Fed remained sober about U.S. economic prospects.
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Members "generally agreed that the economic outlook, while a bit stronger overall, was broadly similar to that at the time of their January meeting," the minutes said.
(Reporting By Pedro da Costa and Mark Felsenthal)


Capturing APC Benefits from Secondary Units
7 September 2016
Advanced Process Control has been used for many decades on wide variety of major process units such as crude distillation units, Hydrocrackers, FCC, Hydrotreaters and Reformers. However, due to a lack of understanding of achievable benefits, shortage of APC resources and gap in APC technology, some organizations do not implement APC on
secondary units, leaving significant benefits on the table.
This paper describes the benefits of implementing APC applications on secondary units to improve margins and help achieve operational excellence.
Download Whitepaper


Where to Find Free Rain Barrels
Many people wonder where they can find inexpensive rain barrels that don't cost $100 or more. Inexpensive or even free (plus the cost to retrofit) rain barrels are definitely out there, but you have to know where to look (or who to ask!). Of course you can always go the do it yourself route and retrofit a plastic trash can, but if you can find a rain barrel for free, then go for it.
Here's my list of where to find free rain barrels:
Sponsored links (article continues below):
1. Municipalities and Water Utilities
Many municipalities these days are encouraging water saving devices like rain barrels, and as a result, often give them away for free. They probably have a limited supply or may only offer them on certain days or at specific events. They may refer you to the water utility company.
2. Non-profit Organizations
If your municipality has no advice, then check out non-profit environmental organizations. They may have giveaways or know of places where you can get free or inexpensive rain barrels.
3. Car Wash
I've heard that car washes may have 55 gallon barrels that can be retrofitted as rain barrels but have never investigated it myself. I've also heard that they recycle them back to the supplier, but it never hurts to ask.
4. Feed Supply Store
If you live in a rural area, then another resource to try is the feed supply store where grains might be sold in large containers suitable for rain barrels.
5. Food or Beverage Manufacturing Facility
I've heard that in Atlanta, GA people can get 55-gallon drums from the Coca-Cola bottling plant for free. This may hold true for other food and beverage manufacturing or bottling facilities.
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NMU is the only university that offers 5 accredited / approved programs by the National Accrediting Agency for Clinical Laboratory Science. It is one of two universities nationwide that offers both a Diagnostic Molecular Science and Cytogenetics program. Clinical internships are offered by ten affiliate hospitals in the Upper Peninsula, eight affiliate hospitals in the Lower Peninsula and five from out of state, including: Marshfield Clinic, Mayo Clinic, Essentia Health, Bay Area Medical Center, and Memorial Medical Center.
The job outlook for all areas of Laboratory Science is excellent, with the need for qualified technologists expected to grow by 11-14% over the next ten years (US Bureau of Labor and Statistics). This projected growth will be powered by an increased need for services due to an aging population who will rely heavily on clinical testing to diagnose and manage medical conditions, such as cancer or diabetes. Additionally, there is a tremendous shortage of laboratory professionals, with over 40,000 laboratory jobs unfilled in the United States (Advance for Laboratory Professionals). Couple the current workforce shortage with the fact that an estimated 40% of aging lab professionals are expected to retire by 2018 and the need to grow new technologists becomes crucial.


This paper has been added to your cart ($35.00) Capsicum annuum L. belonging to the family Solanaceae is a popular spice in Thailand. The mature fruits (long red pepper) are composed of carotenoid, capsaicinoid and ascorbic acid exhibiting physiological and pharmacological properties. Because of environmental pollution, these fruits might be contaminated with toxic heavy metals. Therefore, the objective of this study was to determine the concentrations of eleven heavy metals in long red pepper using nitric acid digestion followed by ICP-MS analysis. Thirteen samples of fresh fruits were collected from nine provinces located in the west of Thailand. The concentrations of toxic heavy metals including arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) in all samples were lower than the permissible limits (4, 0.3, 0.02, and 10 mg/kg, respectively) while the concentrations of essential elements including copper (Cu) and zinc (Zn) were less than the permissible limits (20 and 100 mg/kg, respectively). The highest concentrations of aluminium (Al), chromium (Cr), iron (Fe), manganese (Mn), and nickel (Ni) found were 36.813, 0.345, 44.464, 32.172, and 1.623 mg/kg, respectively. The method adopted in this study could be valuable in quality control of edible spices for Thai people.


Despite mixed economic data, several factors have car dealers scrambling to restock inventory
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LOS ANGELES--Sept. 27, 2013: Blair Stover has chronicled a new circumstance that is limiting sales growth in the American auto industry. A buying frenzy has left car dealers with minimal inventory as consumers clamor for particular models in high demand. While broad economic data remains mixed, Blair Stover notes that several factors are spurring consumers to buy a select group of cars at record high prices.
A low interest rate environment is cited to be pivotal in helping Americans justify the expense and commitment of a new vehicle. Blair Stover points to a 14% year-over-year increase in light truck and car sales for the month of August being greatly attributed to affordable monthly payments that stem from low APR (Annual Percentage Rate) financing.
The positive impact of low APR rates on car sales in uncertain economic times is separately noted by the Wall Street Journal in a September 2nd, 2013 article. The inelastic demand has driven up prices on popular models such as the Ford Fusion, Chevrolet Impala and Nissan Sentra, according to findings from Blair Stover.
These price hikes are in stark contrast to an overall decline of 0.8% in year-over-year car prices, as reported by TrueCar, an automotive shopping site.
A broader trend in car preferences has been affirmed by the supply shortages. The common denominators of fuel efficiency, utility and ample standard features are attracting buyers in droves to small or mid-size sedans. Smaller sport utility vehicles (SUVs) also rank high on many car shopping lists.
Meanwhile, Blair Stover points to a mounting surplus and big rebates on large SUVs, sports cars and pickup trucks going mostly unnoticed by American car buyers. He forecasts that automakers will continue to allocate their production resources to economical and fuel efficient vehicles for the foreseeable future.


In his March 5 Letter, Daniel Greenbaum states that 401(k)s "were designed to shift the risk of retirement from corporations to their workers." That isn't exactly correct because even with defined benefit plans, i.e. pension plans, the corporation doesn't bear the ultimate risk.
Pensions are guaranteed by the Pension Benefit Guaranty Corporation, a U.S. government agency. If a corporation files for bankruptcy, such as LTV Steel, or is being liquidated, such as Reliance Insurance, the PBGC can step in and assume...


Sunday, February 19, 2012: 8:00 AM-9:30 AM
Room 121 (VCC West Building)Data are expensive and sometimes irreplaceable. And yet, the tradition in much of science is that data are not broadly shared. As a result, these data are not used to their full potential. Through global public data archiving, we can verify existing findings, reduce duplicate effort, facilitate meta-analysis, and answer new scientific questions. Funders and journals are now implementing stronger data sharing policies, and these sometimes present challenges to individual researchers. To allay concerns, it is crucial that we be able to document the benefits and costs of data-sharing. What are scientists' concerns about sharing data? How does limited distribution of datasets impede scientific progress? What opportunities for transparency, discovery, broadened participation, and training do we forgo as a scientific community? Are these benefits hypothetical or demonstrable? Can we realize the community benefits without sacrificing the interests of investigators who collect data? This session will address the costs and benefits of public data archiving through examination of both personal experience and large-scale quantitative analysis. Several domains will be considered, with particular highlights on the implications of data sharing and withholding on cancer research and the Gulf of Mexico oil spill.
Organizer:
Heather A. Piwowar, NESCent and the University of British Columbia
Co-Organizer:
Michael C. Whitlock, University of British Columbia
Speakers:


It was $42.95, which seemed reasonable to me. Though, you can find them cheaper online if you're willing to wait for delivery. I wanted an answer ASAP, because I'm the impatient type. Remember having to wait weeks for results? Yeah, that was anxiety inducing. With OraQuick, you've an answer in under 30 minutes.
At first glance, the test appears a bit daunting. (What is this, a Voight-Kampff machine?) But really, it's a lot more simple than it looks. There's a lot of clutter in the box, including a pencil and a disposal bag and some literature on HIV testing and AIDS.
Easy peasy: It's just a quick swab of the gums, and drop the tester in a vial of whatever this clear liquid is. Then you wait. (That part is
stilla bit stressful. I made grilled cheese sandwiches to pass the time.)
The entire process in two pictures:
Twenty minutes later you've your results. It's much like a pregnancy test, with the pink lines indicating a positive or negative result.
If you're sexually active, you should get yourself tested. Know your status. Know your partners' status. Test regularly. OraQuick makes it quick, easy, and confidential.


January 9, 2017
Thank you for your support last year and leading into 2017! We are grateful for your commitment to advancing the sexual health and rights for all people whether through your engagement, expertise, advocacy, or contributions to SIECUS.
In the first week of 2017 alone, we’ve already seen just how critical this commitment will be to protect policies and resources that support a sexually healthy nation.
Since the swearing-in of the 115
th Congress on January 3, the Senate Majority introduced a Budget Resolution setting in motion the Republican effort to repeal the Affordable Care Act while making toothless promises to replace it in 2–3 years. And just this past Thursday, Speaker of the House Paul Ryan confirmed that these efforts will include attempts to defund health care at Planned Parenthood.
Additionally, with nearly two-thirds of the state legislative sessions already underway, we know the fights are also closer to home. Already in Kentucky, we’ve seen the advancement of an anti-abortion bill in their Senate and in Missouri, a bill has been introduced to prohibit transgender students from using the restroom consistent with their gender identity.
We know these attacks on sexual and reproductive health and rights are nothing new, but their frequency and intensity will continue in the coming months.
Join us in our resolve to fight even harder to protect the sexual health and well-being for all by staying informed, spreading the word, and making sure your voice is heard. Sharing emails like these, responding to future action alerts, and following SIECUS on Facebook or Twitter for timely updates is a great start to building our collective knowledge and power.


Health Benefits of Coffee
Hey, coffee lover. Did you know that drinking coffee on a daily basis bring many health benefits? And the good thing is, it’s backed up by science. So it’s not just any myth. Without further ado, here are some reasons why drinking coffee is good for the body.
1. It boosts energy levels.
2. It helps burn fat faster. 3. Caffeine helps improve physical performance. 4. Coffee contains nutrients good for the body. 5. It reduces the risk of Type 2 Diabetes. 6. Drinking coffee helps prevent Alzheimer’s disease. 7. It reduces the risk of Parkinson’s. 8. It helps protect the liver. 9. Drinking coffee makes us happier. 10. It lowers the risk of some types of cancer.
source: http://www.wishinguwell.com/blog/health-benefits-of-coffee-infographic/
2
Visual Communication - 60%
Design - 60%
Content/Script - 65%
Usability - 75%
65%
Final Grade
This infographic offers information on coffee's health benefits. While there is a lot of text, the list format is effective, and the visuals guide the eye through the infographic. However, though visuals pull the viewer through the content, the visual style is not consistent. The usage of both iconography and photography is distracting. For a design to be extremely effective, it's best to move forward with only one design aesthetic. Moreover, as the visuals correspond to the overarching theme of coffee, they do not effectively complement the text. For example, you could illustrate a liver for point #8 to better visualize the text's meaning. For a more effective design, condense copy, establish a visual theme, and ensure that the visuals align with their topical subject matter. In sum, use visuals throughout the infographic to communicate the idea that each point is presenting, and a unified design scheme to root your audience in a theme. As it stands now, we'd give this a D.


Q.: We have a sidewalk that has scaled. The contractor who built it didn't seem to be competent; he didn't even use a jitterbug. Doesn't this warrant our demanding that he repair or replace it? A.: Surface scaling can result from any of a number of conditions or practices, including an inadequate air content, excessive water in the mix, finishing while bleed water is still on the surface, adding water while finishing, inadequate curing, or applying deicers before the slab has dried adequately after curing. Actually, using the jitterbug is not recommended unless the slump of the concrete is less than 3 inches or the concrete is made of lightweight aggregate. Otherwise using the jitterbug could contribute to scaling, not prevent it.


Energy-Efficient Traffic Signals and Streetlights
The use of energy efficient traffic signals, streetlights. and other outdoor area lighting presents a significant opportunity for local governments to lower energy bills and improve the quality of lighting service. The electricity used for outdoor area lighting accounts for a significant portion of a local government's energy bill. Streetlights alone can represent from five percent to over 60 percent of a municipal government's energy expenditures.
This page includes resources and funding opportunities available to local governments in the region who are seeking to retrofit traffic signals, streetlights, and other outdoor area lighting with more energy-efficient technology.
The Regional Streetlight Procurement Program (RSLPP) assembles the resources needed to design, procure, and finance the transition to LED street lighting tailored to each municipality’s specific needs.
This short, easy to read booklet provides an overview of the key opportunities for streetlight and traffic signal retrofits, and provides information on where to go for additional resources and funding opportunities.
The U.S. DOE Municipal Solid-State Street Lighting Consortium collects, analyzes, and shares technical information and experiences related to LED street and area lighting demonstrations. The Consortium also provides an objective resource for evaluating new products on the market intended for street lighting applications. DVRPC encourages all municipalities in the region to become a member of the consortium.


<< Thursday, January 14, 2010 >>
1 Samuel 4:1-11 View Readings
Psalm 44:10-11, 14-15, 24-25
Mark 1:40-45 Similar Reflections
THE ABOMINABLE PRAYER
"When the ark of the Lord arrived in the camp, all Israel shouted so loudly that the earth resounded." —1 Samuel 4:5
"Israel was defeated by the Philistines, who slew about four thousand men on the battlefield" (1 Sm 4:2). "So the people sent to Shiloh and brought from there the ark of the Lord of hosts" (1 Sm 4:4). After praying, the Israelites went into battle again. This time, they suffered a much more disastrous defeat in which thirty thousand of their soldiers were killed (1 Sm 4:10). Their prayers seemed not only ineffective, but even to have made matters worse.
The moral of this incident is not that prayer is sometimes bad; rather, that prayer without repentance can do more harm than good. For example, if we pray without forgiving others, we in effect curse ourselves. Even if we don't say it, the Lord will take our prayer to mean: "Forgive us the wrong we have done as we forgive those who wrong us" (Mt 6:12). Also, if we are unjust and unrepentant, the Lord promises: "When you spread out your hands, I close My eyes to you; though you pray the more, I will not listen. Your hands are full of blood!" (Is 1:15)
When we don't repent, even our liturgical feasts and songs of worship are hated by the Lord (Am 5:21, 23). The writer of Proverbs puts it bluntly: "When one turns away his ear from hearing the law, even his prayer is an abomination" (Prv 28:9). "The sacrifice of the wicked is an abomination to the Lord, but the prayer of the upright is His delight" (Prv 15:8). Repent, pray, and please the Lord.
Prayer: Father, may I not merely pay You lip-service (Mt 15:8). "A heart contrite and humbled, O God, You will not spurn" (Ps 51:19).
Promise: "Moved with pity, Jesus stretched out His hand, touched Him, and said: 'I do will it. Be cured.' The leprosy left him then and there, and he was cured." —Mk 1:41-42
Praise: When the Smiths repented and stopped using artificial contraception, their prayer life changed for the better.
Rescript: In accord with the Code of Canon Law, I hereby grant the Imprimatur ("Permission to Publish") for One Bread, One Body covering the period from December 1, 2009 through January 31, 2010. †Reverend Joseph R. Binzer, Vicar General of the Archdiocese of Cincinnati, June 4, 2009.
The Imprimatur ("Permission to Publish") is a declaration that a book or pamphlet is considered to be free of doctrinal or moral error. It is not implied that those who have granted the Imprimatur agree with the contents, opinions, or statements expressed.


Found At:Midwest Research-to-Practice Conference in Adult, Continuing, and Community Education
Abstract:
In this paper I call attention to unique perspectives among workers and reassert that “worker” does not denote a categorical monolith, but rather a unique human being who perceives the same phenomena differently from everyone else. I position my assertion within the context of the seemingly unquestioned notion of the protean career. Referring to stories by people who participated in a qualitative study I conducted in 2001, I caution that the “emancipatory” qualities of the protean career might not be universally accepted; rather, for personal reasons of one’s own, these same characteristics could be perceived as disruptive of the order that one has constructed. Conclusions suggest that there may be workers like the people in the study I conducted, who find themselves engaged in the proteanenvironment against their will. Even though on the surface they could be said to be taking their place among the residents of “free agent nation”, they might have preferred uninterrupted citizenship in the company wherein they were employed. Implications point to the importance of problematizing the blind acceptance and generalizability of the protean career.


Riverdale, N.Y. October 28, 2015 The College of Mount Saint Vincent has been awarded a grant from the George I. Alden Trust to maintain the exceptional quality of the Colleges nationally-recognized programs in the natural sciences and nursing. The grant will provide $150,000 to support the Colleges efforts to create a new laboratory suite to enhance instruction and student research in the field of microbiology. The microbiology laboratory is the final component of a comprehensive renovation and modernization of the Colleges Science Hall.
To date, the College has created eight new science laboratories which have enabled curriculum innovation in chemistry, genetics, ecology, and neurobiology and have facilitated new learning opportunities for the Colleges diverse population of talented and ambitious students.The project has included the creation of group study spaces on each floor of the building, the renovation of classrooms and faculty offices, and has enabled the installation of new windows and doors, and an ADA compliant elevator, as well as a HVAC system.
The new laboratories have ensured the academic rigor of the Colleges science programs, which are well enrolled and academically strong, with natural science majors comprising 10% of the undergraduate population. Additionally, the laboratories have facilitated new opportunities by enabling student and faculty research. In recent years, two faculty members have received funding from the National Institutes of Health (NIH) to conduct research on chromosomal development. These faculty members engage students as research assistants and collaborators. Faculty members also recruit students to participate in research conducted in collaboration with institutions including Brown University, Rockefeller University, and St. Johns University.
This award builds on the Alden Trusts philanthropy to the College. Previous gifts from the Trust have supported laboratory modernization, as well as gifts to the Elizabeth Seton Library, and the Colleges scholarship program.


In the aftermath of the financial crisis, the spotlight is even more on the role and activities of the CFO. CFOs need to embrace the new challenges and opportunities created by the financial crisis. This title provides the fundamental road map to success in this environment for finance officers, their teams, and the organizations who employ them.
Върни се горе и купи


(Oenothera laciniata)
Cutleaf Evening Primrose – also known as
Oenothera sinuate and Raimannia laciniata – is a biennial, winter or (rarely) a summer annual broadleaf weed. Oenothera laciniata prefers alluvial soils and is commonly found in fields, residential lawns, gardens, and along railroads and roadsides. Cutleaf Evening Primrose can be found throughout the United States, with the exception of Arizona, Colorado, Idaho, Montana, Nevada, Oregon, Utah and Washington.
Identifying Cutleaf Evening Primrose -
Cutleaf Evening Primrose features an underground taproot forming a basal rosette. Branching from the rosette are stems that are hairy, often reddish, and can grow either horizontally or vertically at the tips. Elongated stems can sprawl close to the ground. Cutleaf Evening Primrose can be distinguished from Evening Primrose by its leaves, which feature wavy, irregularly lobed margins: hence the name “Cutleaf” Evening Primrose.
Blooming from May through October, Cutleaf Evening Primrose features small yellow flowers with four petals, although sometimes the flowers can be reddish-brown in color. Reproduction is by seed.
Cutleaf Evening Primrose Control -
Trying to remove Cutleaf Evening Primrose with cultural weed control methods is not recommended. Physical removal (hand pulling) can be difficult due to the large underground taproot.


Cyanobacteria are represented by a diverse group of microorganisms that, by virtue of being a part of marine and freshwater phytoplankton, significantly contribute to the fixation of atmospheric carbon via photosynthesis. It is assumed that ancient cyanobacteria participated in the formation of earth’s oil deposits. Biomass of modern cyanobacteria may be… (More)


Safety Alert - Belt Structures
Two recent structural failures involving
aerial/overhead belt structureshighlight the need to increase awareness of seasonal hazards associated with these systems.
Sub-freezing temperatures contributed to the collapse of a coal stacker belt in Pennsylvania when water and belt spillage being washed from the walkways accumulated and froze on the drip pan.
Rust and deterioration contributed to the collapse of a coal aerial/overhead belt structure in Virginia.
Careful examination and prompt correction of potential safety hazards is essential for the safe operation of these types of conveyor systems. These occurrences can be greatly reduced by utilizing the following best practices:
During winter weather, belt structures should be inspected for excessive accumulations of spillage on walkways, structural members and drip pans.
Modify cleanup programs to accommodate special conditions during periods of inclement weather.
Carefully inspect structures for damaged anchor bolts near the base of the structure, often caused by mobile equipment.
Be on guard for delamination (excessive flaking or erosion) of metal surfaces due to rusting.
Serious cross sectional deterioration or loss of structural steel should be quickly reported and corrected.


By Sue Weishar, Ph.D.
In a remarkable development, a harsh immigration enforcement bill
1 that passed the Mississippi House of Representatives on March 15 with strong support from Governor Phil Bryant and Mississippi Tea Party members died in a Senate Judiciary Committee on April 3, 2012, the last day that action could be taken on any general bills passed by the opposite chamber. 2
Early in the legislative session, Mississippi’s bishops had denounced
3 anti-immigrant legislation, which they argued would threaten the dignity of the human person and negatively impact the progress Mississippi has made in addressing racial injustice. A sign-on letter from evangelical leaders, whose voices had not been heard in prior debates on anti-immigrant legislation, also gained wide support. But in a move that stunned many, Mississippi law enforcement and municipal leaders, including the Mississippi Sheriffs’ Association and Mississippi Association of Chiefs of Police, came out strongly against HB 488 in a letter to lawmakers on March 27, calling it an “unfunded state mandate” that could lead to new taxes. Soon after, leaders of agriculture groups, including the influential Mississippi Farm Bureau, sent a letter to lawmakers warning that the bill could hurt Mississippi’s economy. 4 The next day, the Mississippi Economic Council, effectively a state-wide Chamber of Commerce, opposed the bill.
To better understand how Mississippi arrived at this potentially historic juncture in stopping the spread of state-level anti-immigrant legislation, I interviewed individuals who helped to shape the coalition of new voices, as well as faith and civil rights leaders working for immigration justice in Mississippi.
5
Office Location: Mercy Hall, Room 306 | Mailing Address: 6363 St. Charles Avenue, Box 94 New Orleans, LA 70118


And the entire sum was donated via GiveWell, an organization that researches charities to determine which are the most efficient at saving and improving lives.
Here's why I chose this particular donation strategy—and why you should, too.
As it turns out,
a lotof charities suck. Maybe even most. They're either inefficient, ineffective, lack transparency or have unintended consequences like damaging the local economy. (See examples here and here.) Some are actually worsethan doing nothing at all. For instance, the "Scared Straight" program, which takes kids on tours of prisons to discourage criminal behavior, was found to increasedelinquency compared to doing nothing. Even the practices of big-name charities like Kiva, Smile Train and UNICEF have raised concerns.
But for most people, none of that's really on the radar. They pick a charity based purely on how it resonates with them emotionally. They may see an ad featuring a starving child with sad puppy-dog eyes, skim a few anecdotal endorsements and start reaching for their pocketbook. All without doing any research. Sure, their hearts are in the right place, but isn't it more important to ensure that we're actually helping people? It's okay to let our emotions drive our generosity, but we need to let reason steer us toward options that will do the most good.
Offer strong evidence of positive impact Are extremely cost-effective Will use added funding productively, without diminishing returns Are highly transparent and accountable


Proficient readers ask themselves questions about a text. Asking and answering questions like "what's important here?" and "who's speaking now?" helps readers interact with the text and engage prior knowledge. They are also addressing Common Core State Standards related to key ideas and details and the integration of knowledge and ideas. Teach struggling readers' how to engage in self-questioning to increase engagement and comprehension. Use hypertext and collaborative documents to support your students' experimentation with this approach.
Click here for a version of this slideshow which can be used with a screen-reader and is 508 Compliant.
Using a self-questioning strategy can encourage struggling learners to monitor their understanding of the text. Your clear explanations can highlight critical features of the self-questioning approach, especially when you integrate a range of technology tools as suggested below.
Steps:


Gravity is the most powerful force acting on your body. Because gravity exerts its force evenly, it can create strain in unbalanced bodies. Where there is strain on your body, your tissues shorten and restrict your movement, often causing pain. Over the years, if your body is misaligned in gravity, you may experience chronic strain, pain, lowered vitality, and impaired function.
Rolfing restructures and balances your body through soft tissue manipulation and movement education. This lengthens and frees your connective tissues, which releases strain and tension and allows your body to return to a more natural, symmetrical alignment. Because your body is better balanced after Rolfing, you expend less energy, experience less pain, move more easily, and your overall function is improved.
Rolfing can:
Complimentary consultations are available for new clients. If you
have further questions about Rolfing or to schedule an appointment, contact Steve
at:
The word Rolfing is a service mark of The Rolf Institute®, Boulder, Colorado, USA.


Starting in 2009, the Department of Entomology at Iowa State University received reports of severe corn rootworm injury in Bt corn in Iowa. In all cases, western corn rootworm was the predominant rootworm species in these fields.
The Gassmann lab compared survivorship of western corn rootworm collected from these problem fields vs. insects from control fields (not associated with performance issues). The results were recently published in an article by Gassmann et al. (2011),Field-evolved resistance to Bt Maize by western corn rootworm. In general, survival on Cry3Bb1 corn was significantly higher for larvae from problem fields compared to control fields. Cry3Bb1 corn is sold commercially under the names YieldGard RW and YieldGard VT Triple. The publication also showed no cross-resistance with the Cry34/35Ab1 protein.
This research reports the first time a beetle has evolved resistance to a Bt crop in the field. But maybe these findings are not a total surprise. The Bt proteins targeting corn rootworm are not considered high dose like they are for European corn borer. Additionally, resistant strains of western corn rootworm can be produced in a lab within three generations, which translates to three summers in an Iowa cornfield.
Management Considerations
The number of fields with resistance to Cry3Bb1 corn is small at this time. But it should be noted that similar damage has been reported in Illinois, Minnesota, Nebraskaand South Dakota. This research highlights the importance of incorporating integrated pest management (IPM) and insect resistance management (IRM) into field crop production. All problem fields visited in 2009 had a production history of at least three years of continuous corn with the Cry3Bb1 protein, and this likely contributed to the development of resistance.
The most effective way to prevent widespread rootworm resistance is to use sound IRM and IPM for Bt corn targeting corn rootworm. Crop rotation is among the most effective management strategies for controlling western corn rootworm in Iowa. Also, consider rotating Bt proteins if planting continuous corn. Always comply with refuge requirements for the seed type, which can range from 5% to 20%. A soil-applied insecticide can be used with a non-Bt hybrid or could supplement root protection for Bt corn in areas with known high larval pressure. All cornfields should be evaluated annually by assessing root injury from corn rootworm and management strategies should be adjusted if injury above 0.5 nodes is observed for roots that are protected against corn rootworm.


The G20 has published a communique following the meeting of finance ministers and central bank governors in Chengdu, China, on 24 July 2016. Points of interest in the communique include the following: (i) the G20 remains committed to finalising remaining critical elements of the regulatory framework and the timely, full and consistent implementation of agreed financial reforms; (ii) the G20 welcomes the FSB consultation on proposed policy recommendations to address structural vulnerabilities from asset management activities; (iii) it continues to closely monitor, and if necessary, address emerging risks and vulnerabilities in the financial system, including those associated with shadow banking, asset management and other market-based finance; and (iv) it encourage members to close the gap in the implementation of the Principles for Financial Market Infrastructures (PFMIs) and accelerate their actions on OTC markets reforms.


Nescafe, You Have Got to Hand It to them
Of all the instant coffee products of Nescafé, Nescafé Gold is its premier product.
Nescafe Gold is being served in various places and establishments, from grocery stores to vending machines in parks, universities, offices, malls, and train stations, and even in army mess halls.
While it costs approximately $10 per 200 gram bottle, it is more expensive than other popular instant coffee brands, such as Maxwell Coffee House and Folger’s, Nescafé Gold is still preferred by a lot of instant coffee drinkers due to its richer aroma, smoother taste, and stronger flavor.
And instant coffee drinkers prefer it over gourmet coffee since it is more affordable and easier to prepare, since it does not require the use of coffee makers and coffee grinders to enjoy a cup of coffee. Health advocates also prefer it due to its low caffeine and calorie content.
The success of Nescafé Gold can be attributed not just to its quality, but also to its clever marketing campaign in the 90’s.
During that time, Nescafé Gold was being marketed to a social-climbing, middle-class audience.
Today, Nescafe Gold can be found in just about any country and is enjoyed in millions of homes around the world.
Therefore, we’ve got to hand it to Nescafe. Despite the recent significant increase in the interest for gourmet coffee, Nescafé still remains as the largest coffee roaster in the world and still continues to bring affordable, yet high quality instant coffees to millions of people around the world, who want to enjoy good coffee without any fuss.
If you have developed a new-found love for coffee, why not start with Nescafé in your own home before you start dabbling in gourmet coffee?


Try to stay hydrated throughout each day, not just while you're out on the road. A good rule of thumb is to drink half your body weight in ounces of fluids. So if you weigh 150 pounds, aim for 75 ounces of water per day. If you weigh 100 pounds, aim for 50 ounces. It's best to stick with calorie-free drinks like water. You won't need sports drinks unless you're working out for more than an hour.


The response to treatment and risk factors for early mortality following initiation of combination antiretrovirals(ARVs) in a cohort of African patients are described in a retrospective cohort design. Medical history, laboratory parameters, and mortality data were reviewed for patients initiating ARVs in 12 clinical centers in Mozambique, Tanzania, and Malawi. Among 3456 HIV-1-infected patients who received ARVs for more than 6 months, at baseline 72% had WHO clinical stages 3/4, 7% had a viral load 400 copies/ml, and 38% had a CD4 cell count >200/microl. One year later, 78% had undetectable virus loads and 79% had CD4 cell counts >200 cells/mm3. In the first year of HAART 260 deaths occurred (97 per 1000 person/years) with mortality peaking in the first 3 months. The highest mortality was observed in patients with low BMI, low hemoglobin levels, and CD4 values <200 cells/microl at baseline. Mortality rates following initiation of HAART are higher in patients in resource-limited areas, particularly in the first 90 days following treatment initiation.HAART initiated at higher CD4 cell count levels, especially among malnourished and/or anemic patients, will carry significant public health impact.


Systemic sclerosis is a connective tissue disease characterized by fibrosis of the skin, internal organs, and widespread vasculopathy. Raynaud's phenomenon and digital ulcers are vascular manifestations of this disease and cause significant morbidity. Current treatments are only moderately effective in reducing the severity of Raynaud's in a portion of… (More)


2multi-purpose hall, additional break-out rooms and a new delegate cafe. To accommodate the impact this growth will have on its wireless network, EICC began exploring a cloud-based wireless LAN solution to solve critical capacity, operational and scaling burdens which they were facing with their previous Wi-Fi network solution. ADTRAN’s Bluesocket vWLAN solution virtualizes WLAN control and management on centralized software residing in the cloud, enabling EICC to avoid the substantial expense and operational constraints inherent with traditional WLAN hardware-based controller solutions. With traditional hardware controllers, IT must manage access points by location while facing prohibitive scaling constraints. The vWLAN control and management software and Bluesocket access points can be located independent of each other – anywhere in the networked world. This provides a more dynamic and flexible solution to address network demands in real time, and supports ten times the amount of access points than a hardware based controller can support. As a result, the EICC benefits from greater scalability, simplified administration, a reduced Total Cost of Ownership (TCO), increased capacity, and integrated guest access services to support its various events. Eliminating Wi-Fi hardware controllers, which can account for up to 80% of the energy consumption in a wireless network, also helps EICC meet its green IT initiative goals set forth by its corporate sustainability strategy.


Readers: This is article 4 of 25 from my no-nonsense “Mortgage Basics” quick-reference series.
An adjustable rate mortgage, otherwise known as an ARM mortgage, is a home loan that uses the property being purchased as collateral. Unlike a fixed-rate mortgage where the interest rate never changes, an adjustable rate mortgage has a fixed rate for a limited introductory period that typically varies between three and ten years. After that, the interest rate fluctuates up or down for the rest of the loan term.
For example, a 3/1 arm sets your interest rate for the first three years, and then adjusts annually for the next 27, assuming a typical 30-year loan period. Other common examples include 5/1, 7/1, and 10/1 ARMs.
Since the initial interest rate for an ARM is almost always less than a fixed-rate mortgage, the monthly payments are less. However, that can change if interest rates rise significantly over the life of the loan.
ARMs may be a viable option for those who expect any of the following: Interest rates will fall in the future They’ll refinance before the introductory period expires Their future income will rise, thereby offsetting potential higher payments They’ll sell their home before the initial interest rate increases On the other hand, you should avoid an ARM if: You’re risk averse You’re uncertain whether your income will be higher in the future
Photo Credit: GotCredit


Science of the InvisibleEducation costs money. Ignorance costs more.PagesHomeAboutWednesday, February 20, 2013Does technology enhance learning?"Does technology enhance learning? It's not unreasonable to ask this question, but unfortunately it's the wrong question. A better question is: how can we design technology that enhances learning, and how can we measure that enhancement?"Adrian Kirkwood, Linda Price. (2013) Technology-enhanced learning and teaching in higher education: what is ‘enhanced’ and how do we know? A critical literature review. Learning, Media and Technology doi:10.1080/17439884.2013.770404A.J. CannEmail ThisBlogThis!Share to TwitterShare to FacebookShare to PinterestLabels:Higher Education,TechnologyNo comments:Post a CommentNewer PostOlder PostHomeSubscribe to:Post Comments (Atom)


The American Society of Addiction Medicine (ASAM) has created an informational slide deck in conjunction with the release of the ASAM National Practice Guideline for the Use of Medications in the Treatment of Addiction Involving Opioid Use. This slide deck provides explanations on why this guideline was made and who contributed to its development. It also gives an overview of how physicians assess, diagnose and treat opioid use disorder with any of the medications that are FDA-approved. This guideline is the first of its kind to include all FDA-approved medications in one document. Speaker notes on the entire slide deck is also included on this page.


HOW WE LIVE OUR VALUES
Everybody who is connected to BSL – close or distant – is an important part of bringing our shared mission alive. As such, each of us signs a personal commitment as a stakeholder of BSL to our desire of collaborating towards a better world.
None of us claims to be perfect – we are all on a personal and shared journey of learning and as such, rather than seeking perfection, we use these values to guide our personal and institutional development.
“There is no planet B.”- 50+20 “The day we stop learning, we start dying.” - Unknown
While these values are related to the BSL mission and serve as a guiding basis for our way of collaborating and working together while at BSL, we fully recognize and acknowledge that each individual or organization engaging with BSL carries their own values that may go above and beyond what we have jointly established here.
It is our hope that our values do not contradict or violate any such values. Should this nonetheless be the case, please do let us know: info@bsl-lausanne.ch, at the attention of the BSL leadership team. We see both our mission and values as a continuous process of evolution.
“If you don’t risk anything, you risk even more.” – Erika Jong “It is better to ask for forgiveness than for permission.” - Ignacio de Loyola TRANSLATING OUR VALUES INTO OBSERVABLE BEHAVIOR
A wonderful way to engage with our values is to set development goals for us individually or as teams.
OUR PERSONAL PLEDGE
Everybody at BSL, administration, faculty, and students, sign a personal pledge to commit and engage toward our shared mission and values which shall guide our intention, behavior and actions at BSL .


libros arte-arquitectura-diseño-fotografía ciencia cine-teatro-musica clásicos - poesía cocina / gastronomía filosofía - religión - mitología historia - antropología - ciencias sociales infantil-juvenil lingüística - teoría y crítica literaria narrativa comics - ilustración ebooks objetos Gaudí y modernismo Barcelona Picasso ciencia arte y diseño fetichismo literario infantil audiovisuales música (audiov.) arte - arquitectura (audiov.) cine (audiov.) ciencia (audiov.) literatura (audiov.) infantil (audiov.) danza (audiov.) especiales restauración dónde estamos ficha técnica sinopsis
Since the first millennium BCE, nomads of the Eurasian steppe have played a key role in world history and the development of adjacent sedentary regions, especially China, India, the Middle East, and Eastern and Central Europe. Although their more settled neighbors often saw them as an ongoing threat and imminent danger—“barbarians,” in fact—their impact on sedentary cultures was far more complex than the raiding, pillaging, and devastation with which they have long been associated in the popular imagination. The nomads were also facilitators and catalysts of social, demographic, economic, and cultural change, and nomadic culture had a significant influence on that of sedentary Eurasian civilizations, especially in cases when the nomads conquered and ruled over them. Not simply passive conveyors of ideas, beliefs, technologies, and physical artifacts, nomads were frequently active contributors to the process of cultural exchange and change. Their active choices and initiatives helped set the cultural and intellectual agenda of the lands they ruled and beyond.
This volume brings together a distinguished group of scholars from different disciplines and cultural specializations to explore how nomads played the role of “agents of cultural change.” The beginning chapters examine this phenomenon in both east and west Asia in ancient and early medieval times, while the bulk of the book is devoted to the far flung Mongol empire of the thirteenth and fourteenth centuries. This comparative approach, encompassing both a lengthy time span and a vast region, enables a clearer understanding of the key role that Eurasian pastoral nomads played in the history of the Old World. It conveys a sense of the complex and engaging cultural dynamic that existed between nomads and their agricultural and urban neighbors, and highlights the non-military impact of nomadic culture on Eurasian history. Nomads As Agents of Cultural Change illuminates and complicates nomadic roles as active promoters of cultural exchange within a vast and varied region. It makes available important original scholarship on the new turn in the study of the Mongol empire and on relations between the nomadic and sedentary worlds.
*Todos nuestros productos incluyen el IVA, ampliar información


Follow-up times for colorectal cancer screening abnormalities lag behind those for breast and cervical cancers, according to new study of one million patients.
Follow-up times of abnormal screening exams were shorter for breast cancer than they were for colorectal and cervical cancers, according to a recent study involving more than one million individuals who underwent these screenings. Recently published in the
Journal of General Internal Medicine, the study reported the percentages of individuals with abnormal screening exams receiving timely follow-up were: 93.2% to 96.7% of women across breast centers, 46.8% to 68.7% of individuals across colorectal centers, and 46.6% of women at the cervical center.
Led by Dr. Anna Tosteson, the James J. Carroll Professor of Oncology at the Geisel School of Medicine and a faculty member at The Dartmouth Institute for Health Policy & Clinical Practice, the study characterized cancer screening practice variation across seven centers participating in the National Cancer Institute sponsored PROSPR (Population-based Research Optimizing Screening through Personalized Regimens) consortium. Cancer screening abnormality rates and their timely follow-up were examined across the centers and among primary care practices within centers.
The study's authors called the variation in timely screening abnormality follow-up 'concerning' and cited a number of factors which could contribute to the variation in timely follow up, including the underlying complexity of coordinating the next steps in clinical care, differences in the severity of abnormalities detected and the type of follow-up required. They stated, for example, that the "lower follow-up rates for colorectal cancer screening abnormalities may be due to the perceived inconvenience and invasive nature of the procedures involved," adding that patients undergoing colonoscopy "typically need to take time off work, which may pose a barrier especially for lower-income individuals."
The study's authors also noted that federal policies and regulations that encourage timely cancer screening may affect screening follow-up even more than individual patient and health system factors. Such policies exist for breast and cervical cancer screening, but are non-existent for colorectal cancer screening.
"The documented variation in follow-up of abnormal cancer screening tests across centers and primary care practices highlights opportunities for improving cancer screening," Dr. Tosteson said, noting that this is the first PROSPR study to make cross-organ comparisons in screening outcomes.


A new book chronicles “the practices of an activist organization focused on LPFM” during the first low-power licensing window at the turn of the century.
Low Power to the People: Pirates, Protest, and Politics in FM Radio Activism is written by Christina Dunbar-Hester, a professor of Journalism and Media Studies in the School of Communication and Information at Rutgers University, where she is also affiliated faculty in Women’s and Gender Studies. She is also a long-time friend of the low-power FM movement.
Despite its origins as a pirate broadcasting collective, the group eventually shifted toward building and expanding regulatory access to new, licensed stations. These radio activists consciously cast radio as an alternative to digital utopianism, promoting an understanding of electronic media that emphasizes the local community rather than a global audience of Internet users.
In this study Dunbar-Hester examines how political beliefs are expressed though people’s engagement with technologies, and offers insights into media policy that are especially relevant as thousands of new LPFM stations go online.
I’ve read some of her earlier scholarship around LPFM and radio (some papers are available online via her website), so I am excited to read this fuller treatise.


Narrow Band Imaging Improves Early Bladder Cancer Detection
NBI was superior at detecting early bladder tumors and carcinoma in situ, compared with WLI cystoscopy.
Narrow band imaging (NBI) demonstrates high sensitivity in detecting primary non-muscle invasive bladder cancer (NMIBC), a new Chinese study confirms.
In a head-to-head comparison with white-light imaging (WLI) cystoscopy, NBI was superior at revealing early bladder tumors and carcinoma
in situ.
Previous single-center studies investigating NBI have shown favorable results. So investigators led by Zhangqun Ye, MD, and Jia Hu, MD, of Tongji Hospital in Wuhan, China, further evaluated NBI in a prospective, randomized, multi-center study. At 8 research centers, 384 patients suspected of having bladder cancer were evaluated by NBI and WLI cystoscopy in a randomized order. Urologists used a cystoscope that could switch between white light and filtered narrow band light of 415 nm and 540 nm. Suspicious areas were mapped on separate bladder charts for NBI and WLI, and biopsies were taken.
According to results published in
Scientific Reports, 78 patients had a confirmed urothelial carcinoma. The researchers determined that NBI significantly demonstrated 97.7% diagnostic sensitivity compared with 66.7% for WLI. The specificities were 50% and 25%, respectively, and the false positive rates were 50% and 75%, respectively. The researchers also evaluated 300 biopsy specimens and found 98.8% and 75.5% sensitivities for NBI and WLI, respectively.
Among the 41 cancers detected by NBI alone, 16 were pTa, 21 pT1, and 4 pTis. No pTis stage samples were detected by WLI.
“WLI may fail to detect small papillary and subtle flat carcinoma
in situ lesions, which could progress and become invasive. More effective endoscopic methods are needed to detect bladder tumors due to these carcinomas,” the researchers remarked.
Narrow band light is better absorbed by hemoglobin and may increase the visibility of capillaries in the surface mucosa and blood vessels in the submucosa and enhance contrast of superficial tumors. However, a diagnostic standard for NBI images is needed before it can be widely used in clinical practice, according to the researchers.


Emotional deception via the alteration of facial expressions can occur in three ways : simulating an expression involves adopting an expression in the absence of any real emotion; masking an emotion involves replacing a felt emotion with a different emotional expression; and neutralizing an expression involves concealing a felt emotion with a neutral face. Some psychopathic individuals are chameleon-like actors and appear to use their acting skills to effectively manipulate others in various interpersonal contexts. In corporate settings, white-collar criminals with psychopathic characteristics, such as Bernard Madoff, often ﬁnd easy victims by appearing trustworthy, empathetic, and kind. Psychopathic offenders can readily feign remorse and a pro-social attitude to manipulate their way into lower sentences (i.e., manslaughter rather than murder), permissions to appeal their sentences, and undeserved conditional release. Despite their much longer criminal histories and poorer conditional release histories, psychopaths are 2.5 times more likely than non-psychopaths to be released when they apply for parole . Further, these decisions are faulty; psychopathic offenders in both studies spent fewer successful days on release compared to non-psychopaths released. In fact, extended interpersonal contact with a psychopath can lead to less accurate perceptions of psychopathic traits. Despite evidence that psychopathic individuals are successful manipulators, the manner in which they deceive and manipulate others is open to question. Psychopathy arguably is associated with effective emotional deception. The psychopath’s distinctive lack of emotional experience may prevent emotional ‘‘interference’’ in feigning emotional displays. That is, because of the lack of real emotion, there may be less genuine emotion ‘‘leaking’’ onto the false face during a fabricated emotional display. In support of this prediction, Herpetz et al. (2001) found that psychopathic offenders exhibited fewer and less intense facial expressions in response to pleasant and unpleasant emotional images relative to controls. We predict that psychopathic individuals, particularly those with strong interpersonal-affective features of the disorder, will have an advantage when attempting to control their facial expressions during deception because of their lack of emotion; such individuals may express less ‘‘leakage’’ of genuine emotion during deception. However, due to emotional recognition deﬁcits and a lack of understanding of what a sincere expression ‘‘looks like’’, these individuals will not necessarily be proﬁcient at creating a facial expression consistent with the feigned emotion. As predicted, psychopathic traits – speciﬁcally, high levels of interpersonal manipulation – were related to shorter durations of unintended emotional ‘‘leakage’’ during deceptive expressions. In contrast, the erratic lifestyle element of psychopathy predicted greater emotional inconsistency during deceptive displays. Individuals higher in EI – speciﬁcally, the ability to perceive and express emotion – feigned emotions more convincingly than others but were not more immune to emotional leakage.


Gupta-owned Oakbay Investments has questioned the timing of Finance Minister Pravin Gordhan’s legal .
Hospitals are expected to provide security as a matter of routine, especially in their maternity sections.
This reminder comes against the background of a catalogue of instances of newborn babies being snatched by strangers from the maternity sections of hospitals.
The kidnappings are usually attributed to security lapses and the negligence of nurses.
It is unbelievable that babies are still being snatched from hospitals, despite all the warnings and experiences from which they should have learnt.
And it is shocking that a two-day-old baby could be stolen from Coronation Hospital in Johannesburg with both nurses and security staff in full attendance.
The hospital's management must swiftly investigate this gross negligence and bring the culprits to book.


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Title: Head Start Programs: Are They Beneficial to Low-Income, African American Children? An Ethnographic Analysis of School Readiness Author(s): Maxon, Theola; Oladunni, Anita; Jarrett, Robin L. Contributor(s): Jarrett, Robin L. Subject(s): Human Development and Family Studies
Head Start
African-American
Low-Income
Geographic Coverage: United States Abstract: Understanding how head start programs are preparing low income African American children to successfully transition from preschool to kindergarten is important. However, the long term effectiveness of these programs on childrens academic abilities is currently being debated. Therefore, we used an interpretive qualitative approach, guided by resiliency theory, to explore the lives of ten families from an improvised Midwestern neighborhood in an effort to better understand how their head start program was preparing their children for the transition to kindergarten. During two in-depth interviews, one conducted with mothers while their child was enrolled in pre-kindergarten, and one following their childs completion of kindergarten, we asked mothers to rate their childs preparedness for kindergarten. The following three categories emerged: 1) children whos before and after kindergarten preparedness scores increased, 2) children whos before and after kindergarten preparedness scores remained the same, and 3) children whos before and after kindergarten preparedness scores decreased. Five children had an increased in their scores, demonstrating that they exceeded their kindergarten teachers expectations. Four children had consistent scores, demonstrating they met their teachers expectations. Only one child had a decrease in their scores, demonstrating that they struggled to meet their teachers expectations. Based on these findings, we conclude that for the majority of our participants, head start was successful in preparing them for their transition from preschool to kindergarten. This is important because it highlights the significance of head start programs in effectively placing children on the right path for academic success. Issue Date: 2015-05 Genre: Conference Poster Type: Image Language: English URI: http://hdl.handle.net/2142/77746 Rights Information: Copyright 2015 is held by the authors. Date Available in IDEALS: 2015-05-22


Abstract
In Sri Lanka Immunoassays using either viral lysate (Western Blot) or recombinant/synthetic antigen (Line Immunoassay) for anti-HIV capture are still the preferred methods to confirm HIV infection. Three patients infected with HIV-1 presented with Acquired Immunodeficiency Syndrome (AIDS) defining illnesses. Laboratory tests were performed using the routine commercial kits on multiple sera of one patient and same sera from the other two. All patients were strongly positive on the Enzyme Linked Immuno Sorbent Assay (ELISA) test. Yet, HIV-1 infection could not be confirmed using the routine Line Immunoassay. Eventually HIV infection was confirmed in two patients using the Western blot assay but in one patient that was also indeterminate. We were unable to test further due to non-availability of other tests such as nucleic acid testing (NAT) assays to confirm the presence of HIV RNA. This highlights the fact that in resource poor countries, indeterminate results may delay the diagnosis of HIV, if only Line Immunoassays are available. Some end stage HIV/ AIDS patients may not produce antibodies to specific HIV antigens and may give indeterminate or negative results. DOI: http://dx.doi.org/10.4038/sljv.v2i1.5402 Sri Lanka Journal of Venereology Vol.2(1) 2009 pp.25-28


Avoid Dieting On Thanksgiving Day Thanksgiving Day! This is one of my favorite holidays because of the 3 Fs: Family, Football, and Food. Given the great tasting foods available, there is nothing more frustrating than attempting to diet on such a festive day.
However, gaining excessive weight during this time can be equally frustrating. According to the Calorie Control Council, the average American consumes over 4500 calories and 229 grams of fat during Thanksgiving dinner. As a reference point, a pound of fat is approximately 3500 calories. No wonder we feel more stuffed than the turkey following Thanksgiving.
Instead of dieting on Thanksgiving Day, prepare for it. Here are 7 tips on how to prepare for Thanksgiving to reduce your risk of excessive weight gain.
Get 7-8 hours of sleep the night before: Inadequate sleep can lower leptin (hormone that controls feeling of fullness) and increase ghrelin (hormone that controls feeling of hunger). Lower leptin and higher ghrelin hormone levels can contribute to overeating. Some research also has shown that a lack of adequate sleep may cause you to eat more foods that are high in calories, carbs and fats the following day.


Abbreviations: AM = alveolar macrophages;CS = cigarette smoke
Apoptosisis a critical mechanism controlling cellularity in various tissues. Itis so far unknown whether apoptosis plays a role in cigarettesmoking-related pulmonary diseases. It is, however, reported thatinhaled toxic materials such as silica and particle matters induceapoptosis of alveolar macrophages (AMs). This study was aimed to testhypothesis that cigarette smoke (CS) may induce apoptosis of AMs. Inlung tissue specimens obtained from current smokers with pulmonaryemphysema, approximately 0.3% of the AM population were found to bepositive for terminal deoxynucleotidyl transferase-mediated nucleotidenick end-labeling and immunostaining with monoclonalanti-single-stranded DNA (ApoStain; Alexis Corp; San Diego, CA). In
in vitro studies, mouse, rat, and human AMs, and human bloodmonocyte-derived macrophages cultured with aqueous cigarette smokeextracts underwent apoptosis as evidenced by light and electronmicroscopy, and terminal deoxynucleotidyl transferase-mediatednucleotide nick end-labeling. This apoptosis was associated withincreased oxidative stress, Bax protein accumulation, mitochondrialdysfunction, and mitochondrial cytochrome c release, but wasindependent of p53, Fas, and caspase activation. The cigarette smokeextract-induced apoptosis was inhibited by glutathione, ascorbic acid,and α-tocopherol, which are antioxidants known to be present inrespiratory tract lining fluids. In in vivo studies whererats were exposed to the smoke from 10 cigarettes over 5 h in anexposure chamber, approximately 3% of AMs obtained by BAL showedapoptosis after 24 h. To evaluate the role of lung antioxidants inCS-induced AM apoptosis in vivo, glutathione-depleted ratsproduced by administration of buthionine sulfoximine were exposed toCS. There was a significant increase in CS-induced AM apoptosis inglutathione-depleted rats compared with control rats. These results mayprovide information to explain macrophage dysfunction and lung diseasesin cigarettesmokers.


1. Zeldin, Darryl C: 28 articles (07/2015 - 03/2003) 2. Falck, John R: 26 articles (03/2015 - 07/2004) 3. El-Kadi, Ayman O S: 20 articles (08/2015 - 04/2004) 4. Malik, Kafait U: 16 articles (01/2016 - 02/2002) 5. Gonzalez, Frank J: 14 articles (01/2016 - 09/2002) 6. Ingelman-Sundberg, Magnus: 14 articles (01/2015 - 09/2003) 7. Morgan, Edward T: 14 articles (01/2014 - 12/2002) 8. Lee, Craig R: 13 articles (10/2014 - 10/2007) 9. Wang, Lihua: 12 articles (07/2015 - 08/2007) 10. Edin, Matthew L: 12 articles (10/2014 - 07/2007)
1. Neoplasms (Cancer)
03/01/2010 - "One of the major outcomes of recent studies include significantly improved effectiveness of cytochrome P450 directed enzyme pro-drug delivery tools when used in conjunction with P35, which may help in alleviating drug resistance in tumor cells and simultaneously prolonging the cytotoxic effects of anti-cancer drugs. "
10/08/2005 - "A significant reduction in total cytochrome P-450 activity was observed in tumor and tumor-adjacent tissues versus normal stomach. "
01/01/2015 - "Also, various studies have found the expression and activity of orphan human cytochrome P450 4X1 in cancer. "
07/15/2013 - "In the current study, we examined the influence of these compounds on cytochrome P450 3A4 (CYP3A4) and 2C9 (CYP2C9) enzymatic activity and gene expression in HepG2 tumor cells. "
07/01/2013 - "The purpose of this study was (1) to compare the number and types of prescription medications and over-the-counter medications between BCS and midlife women without cancer and (2) to assess possible drug-drug interactions by evaluating the cytochrome P450 isoform properties of medications (inductors and inhibitors) in both groups. "
2. Body Weight (Weight, Body)
09/01/1981 - "In male rats, cytochrome P-450 content based on 100 g body weight decreased only in old rats as compared with immature rats, whereas a significant reduction was observed in female rats in the content based on mg microsomal protein as well as based on 100 g body weight in young and old animals. "
01/01/2014 - "Analyses were performed using NONMEM, and the impacts of body weight, age, race, sex, formulation, liver function, and cytochrome P450 2B6 (CYP2B6)-G516T and multidrug-resistance transporter gene (MDR1)-C3435T polymorphisms were assessed. "
10/01/2013 - "Physiological data related to changes in maternal body weight, tissue volume, cardiac output, renal function, blood flows, and cytochrome P450 activity were collected from the literature and incorporated into the structural PBPK model that describes HV or PP women PK data. "
07/01/2008 - "Both groups did not differ from each other significantly in body weight gain, hepatosomatic index, and condition factor Hepatic level of cytochrome P450 was lower in PSP group than control group. "
01/01/2004 - "Sex-based differences in the four major factors that contribute to interindividual pharmacokinetic variability--bioavailability, distribution, metabolism, and elimination--are theorized to stem from variations between men and women in factors such as body weight, plasma volume, gastric emptying time, plasma protein levels, cytochrome P450 activity, drug transporter function, and excretion activity. "
3. Inflammation
01/01/2015 - "Acute and chronic toxicity, cytochrome p450 enzyme inhibition, and HERG channel blockade studies with a polyherbal, ayurvedic formulation for inflammation."
09/18/1999 - "These studies indicate that inflammation localized to the CNS causes an alteration in the levels and activity of a major cytochrome P450 form in the brain. "
06/01/2015 - "Inflammation-associated microRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9."
01/01/2015 - "However, it is difficult to predict changes in drug exposure in patients because the response to inflammation varies depending on the disease state, its time course, and the cytochrome P450 involved. "
11/01/2014 - "Human cytochrome P450 epoxygenases: variability in expression and role in inflammation-related disorders."
4. Hemorrhage
07/01/2012 - "Systematic review and meta-analysis of the association between cytochrome P450 2C19 genotype and bleeding."
01/01/2009 - "Adjusted odds ratio (OR) for bleeding was highest for cytochrome P450 2C9 (CYP2C9) inhibitors (OR 3.6; 95% confidence interval (CI) 2.4-5.6). "
12/01/2007 - "Cytochrome P450 CYP2C9 polymorphism and NSAID-related acute gastrointestinal bleeding."
09/01/2007 - "Patients with either Cytochrome P-450 CYP2C9*2, CYP2C9*3, or VKORC1*2 genotype (c.-1639G>A) require significantly reduced doses, and are at a higher risk of serious bleeding. "
08/01/2013 - "(13)C-methacetin breath test ((13)C-MBT) - a sensitive non-invasive probe of cytochrome P-450 1A2 activity - was performed in 15 women on day 14, 15, 16, 17 or 18 of intake of their COC (containing EE), and between day 1 and 5 during the withdrawal bleeding, as well as in nine women not using hormonal contraception during the luteal phase of their cycle (between the 17th and the 23rd day), and between day 1 and 5 during menstruation. "
5. Fibrosis (Cirrhosis)
05/01/1995 - "Pharmacokinetic studies in patients with cirrhosis have shown a decreased clearance of drugs metabolized by cytochrome P450, whereas drugs metabolized by glucuronidation frequently have a normal elimination. "
01/01/2000 - "In the presence of cirrhosis, portosystemic shunting occurs and cytochrome P450 activity is reduced. "
07/01/1987 - "The available evidence supports the assertion that specific forms of cytochrome P450 are subject to altered regulation in cirrhosis."
12/01/1969 - "The effect of cirrhosis of the liver on microsomal detoxications and cytochrome P-450."
01/01/2013 - "Although the induction of cytochrome P450 (CYP) has long been investigated in patients with cirrhosis, the question whether liver dysfunction impairs the response to CYP inducers still remains unresolved. "
1. Enzymes 2. Isoenzymes 3. Cytochrome P-450 CYP1A2 (CYP1A2) 4. Omeprazole (Esomeprazole) 5. Aromatase (CYP19) 6. Antipyrine (Phenazone) 7. Cytochromes b5 (Cytochrome b5) 8. Glutathione Transferase (Glutathione S-Transferase) 9. Protein Isoforms (Isoforms) 10. Acids
1. Drug Therapy (Chemotherapy) 2. Castration 3. Total Parenteral Nutrition 4. Transplants (Transplant) 5. Resuscitation


In the UK, human rights are often seen as an international issue - one enacted in dusty prisons in foreign lands - rather than one that affects us closer to home. However, it can be argued that older people in the UK are one significant part of the population that routinely has its human rights denied...
Many people think about these issues too late. For others life events happen and prevent them from saving or contributing to a pension. For many others there simply isn't the money to save when the bills are paid. The Centre for Ageing Better wants more people to feel prepared for later life. We will be exploring how we can contribute to this goal in coming months.
They love the freedom of cycling, feel fit and tell me their electric bikes are the best thing ever, they can now cycle further without pain. It goes without saying that we all wear safety helmets and reflective jackets, you don't get older without getting wiser! So don't delay "on yer bike" and get those wheels turning!


It feels absurd why we bank on this one day to celebrate the spirit of a woman. A mother, a daughter, a sister and a wife, woman has many roles to play and she plays them successfully. But, time and again, she is shown where she stands in society- among the taken for granted and the most deprived.
However, times have changed now and she knows what she is. The fact that she is a woman itself defines her potential as a human being. And this is not what we say alone, but renowned people and various theologies from centuries have believed so. Here are some quotable quotes on women:
"
Women hold up half the sky." - Chinese proverb
"
I love to see a young girl go out and grab the world by the lapels. Life's a bitch. You've got to go out and kick ass."- Maya Angelou "A woman is the full circle. Within her is the power to create, nurture and transform." - Diane Mariechild "How wrong is it for a woman to expect the man to build the world she wants, rather than to create it herself?" - Anaïs Nin "No one can make you feel inferior without your consent." - Eleanor Roosevelt "A strong woman understands that the gifts such as logic, decisiveness, and strength are just as feminine as intuition and emotional connection. She values and uses all of her gifts." - Nancy Rathburn "I always did something I was a little not ready to do. I think that's how you grow. When there's that moment of 'Wow, I'm not really sure I can do this,' and you push through those moments, that's when you have a breakthrough." - Marissa Mayer (CEO of Yahoo) "A woman is like a tea bag - you can't tell how strong she is until you put her in hot water"- Eleanor Roosevelt "The beauty of a woman must be seen from in her eyes, because that is the doorway to her heart, the place where love resides"-Audrey Hepburn "When a woman is talking to you, listen to what she says with her eyes"-Victor Hugo "If you want something said, ask a man; if you want something done, ask a woman"-Margaret Thatcher
Time and again women have been perceived and celebrated by may famous personalities, it is time that we, as women realised our own potential ourselves and set an example of surviving all odds.


Awards
Natural Hormone Enhancement
Recent research has demonstrated that aging, health, and body composition are more closely interrelated than previously suspected, and hormones are the unifying factor. This realization presents the thrilling prospect of using one grand strategy to attack all three areas simultaneously - to arrest aging, while achieving super-health, while at the same time permanently eliminating excess bodyfat. Natural Hormonal Enhancement advances this grand strategy in a detailed and concise form that the average person can easily understand and follow.


I applaud the Singapore Government's effort to establish the Post-Secondary Education Account (PSEA), which acts as a protected savings account that students can tap to pay for things like exchange programmes, enrichment courses and special curricula.
However, a savings account must be coupled with a good and easy mechanism for liquidising the funds.
Currently, if a student wants to withdraw funds to pay for a programme, he has to submit a form which would take approximately five to six weeks for the Ministry of Education (MOE) to process.
Furthermore, students generally are allowed to claim from the PSEA only after they have completed the programme, which means they have to fork out from their own savings first.
As a student, I hope policymakers will rethink these procedures.
The issue of liquidity is paramount.
Realistically speaking, many students do not have much savings; what savings we do have are needed to maintain a decent living in an expensive country like Singapore.
This leads to marginalisation of less well-off students when it comes to expensive programmes, such as exchange programmes and overseas field trips.
If the PSEA is to ease the financial burden of students for educational programmes, then the MOE needs to be more efficient in processing the requests made by students prior to embarking on the programmes.
Perhaps it could create an online platform for students to submit their requests.
This would be more environmentally friendly, would enable forms to reach MOE sooner and allow students to monitor the approval process.
Muhammad Idaffi Othman


Brown fat cells are specialized to dissipate energy and can counteract obesity; however, the transcriptional basis of their determination is largely unknown. We show here that the zinc-finger protein PRDM16 is highly enriched in brown fat cells compared to white fat cells. When expressed in white fat cell progenitors, PRDM16 activates a robust brown fat phenotype including induction of PGC-1alpha, UCP1, and type 2 deiodinase (Dio2) expression and a remarkable increase in uncoupled respiration. Transgenic expression of PRDM16 at physiological levels in white fat depots stimulates the formation of brown fat cells. Depletion of PRDM16 through shRNA expression in brown fat cells causes a near total loss of the brown characteristics. PRDM16 activates brown fat cell identity at least in part by simultaneously activating PGC-1alpha and PGC-1beta through direct protein binding. These data indicate that PRDM16 can control the determination of brown fat fate.


Fresh analysis from the Centers for Disease Control and Prevention suggests the tide may be turning on the childhood obesity front. After decades of steady increases, 19 states and U.S. territories saw small decreases in their rates of obesity among low-income preschoolers. And another 20 states held steady at current rates.


Leaders in public, private and community sectors from across the Asia-Pacific gathered to discuss the future of the region’s forests at the 2016 Asia-Pacific Rainforest Summit held from 3-5 August in Bandar Seri Begawan, Brunei Darussalam.
The event was hosted by the Government of Brunei Darussalam, and supported by the Australian Government as the coordinating partner, with the Center for International Forestry Research (CIFOR) as the science and engagement partner.
In this video, event participants including Peter Holmgren, Director General of CIFO; Josh Frydenberg, Australia’s Minister for the Environment and Energy; and Dato Ali Apong, Brunei’s Minister of Primary Resources and Tourism, discuss the importance of integration – both across the region and between the private and public sectors – to achieve impact.
Visit the event website: http://www.cifor.org/asia-pacific-rainforest-summit/
and join the conversation: #APRS16