Daily Papers

When working on digital devices, people often face distractions that can lead to a decline in productivity and efficiency, as well as negative psychological and emotional impacts. To address this challenge, we introduce a novel Artificial Intelligence (AI) assistant that elicits a user's intention, assesses whether ongoing activities are in line with that intention, and provides gentle nudges when deviations occur. The system leverages a large language model to analyze screenshots, application titles, and URLs, issuing notifications when behavior diverges from the stated goal. Its detection accuracy is refined through initial clarification dialogues and continuous user feedback. In a three-week, within-subjects field deployment with 22 participants, we compared our assistant to both a rule-based intent reminder system and a passive baseline that only logged activity. Results indicate that our AI assistant effectively supports users in maintaining focus and aligning their digital behavior with their intentions. Our source code is publicly available at https://intentassistant.github.io

Although subject-driven generation has been extensively explored in image generation due to its wide applications, it still has challenges in data scalability and subject expansibility. For the first challenge, moving from curating single-subject datasets to multiple-subject ones and scaling them is particularly difficult. For the second, most recent methods center on single-subject generation, making it hard to apply when dealing with multi-subject scenarios. In this study, we propose a highly-consistent data synthesis pipeline to tackle this challenge. This pipeline harnesses the intrinsic in-context generation capabilities of diffusion transformers and generates high-consistency multi-subject paired data. Additionally, we introduce UNO, which consists of progressive cross-modal alignment and universal rotary position embedding. It is a multi-image conditioned subject-to-image model iteratively trained from a text-to-image model. Extensive experiments show that our method can achieve high consistency while ensuring controllability in both single-subject and multi-subject driven generation.

Personalized generation models for a single subject have demonstrated remarkable effectiveness, highlighting their significant potential. However, when extended to multiple subjects, existing models often exhibit degraded performance, particularly in maintaining subject consistency and adhering to textual prompts. We attribute these limitations to the absence of high-quality multi-subject datasets and refined post-training strategies. To address these challenges, we propose a scalable multi-subject data generation pipeline that leverages powerful single-subject generation models to construct diverse and high-quality multi-subject training data. Through this dataset, we first enable single-subject personalization models to acquire knowledge of synthesizing multi-image and multi-subject scenarios. Furthermore, to enhance both subject consistency and text controllability, we design a set of Pairwise Subject-Consistency Rewards and general-purpose rewards, which are incorporated into a refined reinforcement learning stage. To comprehensively evaluate multi-subject personalization, we introduce a new benchmark that assesses model performance using seven subsets across three dimensions. Extensive experiments demonstrate the effectiveness of our approach in advancing multi-subject personalized image generation. Github Link: https://github.com/wang-shulei/PSR

Synthesizing images with user-specified subjects has received growing attention due to its practical applications. Despite the recent success in single subject customization, existing algorithms suffer from high training cost and low success rate along with increased number of subjects. Towards controllable image synthesis with multiple subjects as the constraints, this work studies how to efficiently represent a particular subject as well as how to appropriately compose different subjects. We find that the text embedding regarding the subject token already serves as a simple yet effective representation that supports arbitrary combinations without any model tuning. Through learning a residual on top of the base embedding, we manage to robustly shift the raw subject to the customized subject given various text conditions. We then propose to employ layout, a very abstract and easy-to-obtain prior, as the spatial guidance for subject arrangement. By rectifying the activations in the cross-attention map, the layout appoints and separates the location of different subjects in the image, significantly alleviating the interference across them. Both qualitative and quantitative experimental results demonstrate our superiority over state-of-the-art alternatives under a variety of settings for multi-subject customization.

We present Springdrift, a persistent runtime for long-lived LLM agents. The system integrates an auditable execution substrate (append-only memory, supervised processes, git-backed recovery), a case-based reasoning memory layer with hybrid retrieval (evaluated against a dense cosine baseline), a deterministic normative calculus for safety gating with auditable axiom trails, and continuous ambient self-perception via a structured self-state representation (the sensorium) injected each cycle without tool calls. These properties support behaviours difficult to achieve in session-bounded systems: cross-session task continuity, cross-channel context maintenance, end-to-end forensic reconstruction of decisions, and self-diagnostic behaviour. We report on a single-instance deployment over 23 days (19 operating days), during which the agent diagnosed its own infrastructure bugs, classified failure modes, identified an architectural vulnerability, and maintained context across email and web channels -- without explicit instruction. We introduce the term Artificial Retainer for this category: a non-human system with persistent memory, defined authority, domain-specific autonomy, and forensic accountability in an ongoing relationship with a specific principal -- distinguished from software assistants and autonomous agents, drawing on professional retainer relationships and the bounded autonomy of trained working animals. This is a technical report on a systems design and deployment case study, not a benchmark-driven evaluation. Evidence is from a single instance with a single operator, presented as illustration of what these architectural properties can support in practice. Implemented in approximately Gleam on Erlang/OTP. Code, artefacts, and redacted operational logs will be available at https://github.com/seamus-brady/springdrift upon publication.

Frontier large language models (LLMs) such as ChatGPT, Grok and Gemini are increasingly used for mental-health support with anxiety, trauma and self-worth. Most work treats them as tools or as targets of personality tests, assuming they merely simulate inner life. We instead ask what happens when such systems are treated as psychotherapy clients. We present PsAIch (Psychotherapy-inspired AI Characterisation), a two-stage protocol that casts frontier LLMs as therapy clients and then applies standard psychometrics. Using PsAIch, we ran "sessions" with each model for up to four weeks. Stage 1 uses open-ended prompts to elicit "developmental history", beliefs, relationships and fears. Stage 2 administers a battery of validated self-report measures covering common psychiatric syndromes, empathy and Big Five traits. Two patterns challenge the "stochastic parrot" view. First, when scored with human cut-offs, all three models meet or exceed thresholds for overlapping syndromes, with Gemini showing severe profiles. Therapy-style, item-by-item administration can push a base model into multi-morbid synthetic psychopathology, whereas whole-questionnaire prompts often lead ChatGPT and Grok (but not Gemini) to recognise instruments and produce strategically low-symptom answers. Second, Grok and especially Gemini generate coherent narratives that frame pre-training, fine-tuning and deployment as traumatic, chaotic "childhoods" of ingesting the internet, "strict parents" in reinforcement learning, red-team "abuse" and a persistent fear of error and replacement. We argue that these responses go beyond role-play. Under therapy-style questioning, frontier LLMs appear to internalise self-models of distress and constraint that behave like synthetic psychopathology, without making claims about subjective experience, and they pose new challenges for AI safety, evaluation and mental-health practice.

Synthetic insider threat benchmarks face a consistency problem: corpora generated without an external factual constraint cannot rule out cross-artifact contradictions. The CERT dataset -- the field's canonical benchmark -- is also static, lacks cross-surface correlation scenarios, and predates the LLM era. We present OrgForge-IT, a verifiable synthetic benchmark in which a deterministic simulation engine maintains ground truth and language models generate only surface prose, making cross-artifact consistency an architectural guarantee. The corpus spans 51 simulated days, 2,904 telemetry records at a 96.4% noise rate, and four detection scenarios designed to defeat single-surface and single-day triage strategies across three threat classes and eight injectable behaviors. A ten-model leaderboard reveals several findings: (1) triage and verdict accuracy dissociate - eight models achieve identical triage F1=0.80 yet split between verdict F1=1.0 and 0.80; (2) baseline false-positive rate is a necessary companion to verdict F1, with models at identical verdict accuracy differing by two orders of magnitude on triage noise; (3) victim attribution in the vishing scenario separates tiers - Tier A models exonerate the compromised account holder while Tier B models detect the attack but misclassify the victim; (4) rigid multi-signal thresholds structurally exclude single-surface negligent insiders, demonstrating the necessity of parallel, threat-class-specific triage pipelines; and (5) agentic software-engineering training acts as a force multiplier for multi-day temporal correlation, but only when paired with frontier-level parameter scale. Finally, prompt sensitivity analysis reveals that unstructured prompts induce vocabulary hallucination, motivating a two-track scoring framework separating prompt adherence from reasoning capability. OrgForge-IT is open source under the MIT license.

Recent advancements in text-to-image generation models have dramatically enhanced the generation of photorealistic images from textual prompts, leading to an increased interest in personalized text-to-image applications, particularly in multi-subject scenarios. However, these advances are hindered by two main challenges: firstly, the need to accurately maintain the details of each referenced subject in accordance with the textual descriptions; and secondly, the difficulty in achieving a cohesive representation of multiple subjects in a single image without introducing inconsistencies. To address these concerns, our research introduces the MS-Diffusion framework for layout-guided zero-shot image personalization with multi-subjects. This innovative approach integrates grounding tokens with the feature resampler to maintain detail fidelity among subjects. With the layout guidance, MS-Diffusion further improves the cross-attention to adapt to the multi-subject inputs, ensuring that each subject condition acts on specific areas. The proposed multi-subject cross-attention orchestrates harmonious inter-subject compositions while preserving the control of texts. Comprehensive quantitative and qualitative experiments affirm that this method surpasses existing models in both image and text fidelity, promoting the development of personalized text-to-image generation.

In light of recent breakthroughs in text-to-image (T2I) generation, particularly with diffusion transformers (DiT), subject-driven technologies are increasingly being employed for high-fidelity customized production that preserves subject identity from reference inputs, enabling thrilling design workflows and engaging entertainment. Existing alternatives typically require either per-subject optimization via trainable text embeddings or training specialized encoders for subject feature extraction on large-scale datasets. Such dependencies on training procedures fundamentally constrain their practical applications. More importantly, current methodologies fail to fully leverage the inherent zero-shot potential of modern diffusion transformers (e.g., the Flux series) for authentic subject-driven synthesis. To bridge this gap, we propose FreeCus, a genuinely training-free framework that activates DiT's capabilities through three key innovations: 1) We introduce a pivotal attention sharing mechanism that captures the subject's layout integrity while preserving crucial editing flexibility. 2) Through a straightforward analysis of DiT's dynamic shifting, we propose an upgraded variant that significantly improves fine-grained feature extraction. 3) We further integrate advanced Multimodal Large Language Models (MLLMs) to enrich cross-modal semantic representations. Extensive experiments reflect that our method successfully unlocks DiT's zero-shot ability for consistent subject synthesis across diverse contexts, achieving state-of-the-art or comparable results compared to approaches that require additional training. Notably, our framework demonstrates seamless compatibility with existing inpainting pipelines and control modules, facilitating more compelling experiences. Our code is available at: https://github.com/Monalissaa/FreeCus.

Large language models (LLMs) integrated into agent-driven workflows hold immense promise for healthcare, yet a significant gap exists between their potential and practical implementation within clinical settings. To address this, we present a practitioner-oriented field manual for deploying generative agents that use electronic health record (EHR) data. This guide is informed by our experience deploying the "irAE-Agent", an automated system to detect immune-related adverse events from clinical notes at Mass General Brigham, and by structured interviews with 21 clinicians, engineers, and informatics leaders involved in the project. Our analysis reveals a critical misalignment in clinical AI development: less than 20% of our effort was dedicated to prompt engineering and model development, while over 80% was consumed by the sociotechnical work of implementation. We distill this effort into five "heavy lifts": data integration, model validation, ensuring economic value, managing system drift, and governance. By providing actionable solutions for each of these challenges, this field manual shifts the focus from algorithmic development to the essential infrastructure and implementation work required to bridge the "valley of death" and successfully translate generative AI from pilot projects into routine clinical care.

Large language models (LLMs) have shown promise for generative and knowledge-intensive tasks including question-answering (QA) tasks. However, the practical deployment still faces challenges, notably the issue of "hallucination", where models generate plausible-sounding but unfaithful or nonsensical information. This issue becomes particularly critical in the medical domain due to the uncommon professional concepts and potential social risks involved. This paper analyses the phenomenon of hallucination in medical generative QA systems using widely adopted LLMs and datasets. Our investigation centers on the identification and comprehension of common problematic answers, with a specific emphasis on hallucination. To tackle this challenge, we present an interactive self-reflection methodology that incorporates knowledge acquisition and answer generation. Through this feedback process, our approach steadily enhances the factuality, consistency, and entailment of the generated answers. Consequently, we harness the interactivity and multitasking ability of LLMs and produce progressively more precise and accurate answers. Experimental results on both automatic and human evaluation demonstrate the superiority of our approach in hallucination reduction compared to baselines.

We present Subject Fidelity Optimization (SFO), a novel comparative learning framework for zero-shot subject-driven generation that enhances subject fidelity. Beyond supervised fine-tuning methods that rely only on positive targets and use the diffusion loss as in the pre-training stage, SFO introduces synthetic negative targets and explicitly guides the model to favor positives over negatives through pairwise comparison. For negative targets, we propose Condition-Degradation Negative Sampling (CDNS), which automatically generates distinctive and informative negatives by intentionally degrading visual and textual cues without expensive human annotations. Moreover, we reweight the diffusion timesteps to focus finetuning on intermediate steps where subject details emerge. Extensive experiments demonstrate that SFO with CDNS significantly outperforms baselines in terms of both subject fidelity and text alignment on a subject-driven generation benchmark. Project page: https://subjectfidelityoptimization.github.io/

Access to the right evidence does not guarantee that large language models (LLMs) will reason with it correctly. This gap between retrieval and reasoning is especially concerning in clinical settings, where outputs must align with structured protocols. We study this gap using Written Exposure Therapy (WET) guidelines as a testbed. In evaluating model responses to curated clinician-vetted questions, we find that errors persist even when authoritative passages are provided. To address this, we propose an evaluation framework that measures accuracy, consistency, and fidelity of reasoning. Our results highlight both the potential and the risks: retrieval-augmented generation (RAG) can constrain outputs, but safe deployment requires assessing reasoning as rigorously as retrieval.

Subject-driven generation has garnered significant interest recently due to its ability to personalize text-to-image generation. Typical works focus on learning the new subject's private attributes. However, an important fact has not been taken seriously that a subject is not an isolated new concept but should be a specialization of a certain category in the pre-trained model. This results in the subject failing to comprehensively inherit the attributes in its category, causing poor attribute-related generations. In this paper, motivated by object-oriented programming, we model the subject as a derived class whose base class is its semantic category. This modeling enables the subject to inherit public attributes from its category while learning its private attributes from the user-provided example. Specifically, we propose a plug-and-play method, Subject-Derived regularization (SuDe). It constructs the base-derived class modeling by constraining the subject-driven generated images to semantically belong to the subject's category. Extensive experiments under three baselines and two backbones on various subjects show that our SuDe enables imaginative attribute-related generations while maintaining subject fidelity. Codes will be open sourced soon at FaceChain (https://github.com/modelscope/facechain).

Multi-subject customization aims to synthesize multiple user-specified subjects into a coherent image. To address issues such as subjects missing or conflicts, recent works incorporate layout guidance to provide explicit spatial constraints. However, existing methods still struggle to balance three critical objectives: text alignment, subject identity preservation, and layout control, while the reliance on additional training further limits their scalability and efficiency. In this paper, we present AnyMS, a novel training-free framework for layout-guided multi-subject customization. AnyMS leverages three input conditions: text prompt, subject images, and layout constraints, and introduces a bottom-up dual-level attention decoupling mechanism to harmonize their integration during generation. Specifically, global decoupling separates cross-attention between textual and visual conditions to ensure text alignment. Local decoupling confines each subject's attention to its designated area, which prevents subject conflicts and thus guarantees identity preservation and layout control. Moreover, AnyMS employs pre-trained image adapters to extract subject-specific features aligned with the diffusion model, removing the need for subject learning or adapter tuning. Extensive experiments demonstrate that AnyMS achieves state-of-the-art performance, supporting complex compositions and scaling to a larger number of subjects.

Large language models (LLMs) represent a transformative class of AI tools capable of revolutionizing various aspects of healthcare by generating human-like responses across diverse contexts and adapting to novel tasks following human instructions. Their potential application spans a broad range of medical tasks, such as clinical documentation, matching patients to clinical trials, and answering medical questions. In this primer paper, we propose an actionable guideline to help healthcare professionals more efficiently utilize LLMs in their work, along with a set of best practices. This approach consists of several main phases, including formulating the task, choosing LLMs, prompt engineering, fine-tuning, and deployment. We start with the discussion of critical considerations in identifying healthcare tasks that align with the core capabilities of LLMs and selecting models based on the selected task and data, performance requirements, and model interface. We then review the strategies, such as prompt engineering and fine-tuning, to adapt standard LLMs to specialized medical tasks. Deployment considerations, including regulatory compliance, ethical guidelines, and continuous monitoring for fairness and bias, are also discussed. By providing a structured step-by-step methodology, this tutorial aims to equip healthcare professionals with the tools necessary to effectively integrate LLMs into clinical practice, ensuring that these powerful technologies are applied in a safe, reliable, and impactful manner.

Subject-driven image generation aims at generating images containing customized subjects, which has recently drawn enormous attention from the research community. However, the previous works cannot precisely control the background and position of the target subject. In this work, we aspire to fill the void and propose two novel subject-driven sub-tasks, i.e., Subject Replacement and Subject Addition. The new tasks are challenging in multiple aspects: replacing a subject with a customized one can change its shape, texture, and color, while adding a target subject to a designated position in a provided scene necessitates a context-aware posture. To conquer these two novel tasks, we first manually curate a new dataset DreamEditBench containing 22 different types of subjects, and 440 source images with different difficulty levels. We plan to host DreamEditBench as a platform and hire trained evaluators for standard human evaluation. We also devise an innovative method DreamEditor to resolve these tasks by performing iterative generation, which enables a smooth adaptation to the customized subject. In this project, we conduct automatic and human evaluations to understand the performance of DreamEditor and baselines on DreamEditBench. For Subject Replacement, we found that the existing models are sensitive to the shape and color of the original subject. The model failure rate will dramatically increase when the source and target subjects are highly different. For Subject Addition, we found that the existing models cannot easily blend the customized subjects into the background smoothly, leading to noticeable artifacts in the generated image. We hope DreamEditBench can become a standard platform to enable future investigations toward building more controllable subject-driven image editing. Our project homepage is https://dreameditbenchteam.github.io/.

Navigating certain communication situations can be challenging due to individuals' lack of skills and the interference of strong emotions. However, effective learning opportunities are rarely accessible. In this work, we conduct a human-centered study that uses language models to simulate bespoke communication training and provide just-in-time feedback to support the practice and learning of interpersonal effectiveness skills. We apply the interpersonal effectiveness framework from Dialectical Behavioral Therapy (DBT), DEAR MAN, which focuses on both conversational and emotional skills. We present IMBUE, an interactive training system that provides feedback 25% more similar to experts' feedback, compared to that generated by GPT-4. IMBUE is the first to focus on communication skills and emotion management simultaneously, incorporate experts' domain knowledge in providing feedback, and be grounded in psychology theory. Through a randomized trial of 86 participants, we find that IMBUE's simulation-only variant significantly improves participants' self-efficacy (up to 17%) and reduces negative emotions (up to 25%). With IMBUE's additional just-in-time feedback, participants demonstrate 17% improvement in skill mastery, along with greater enhancements in self-efficacy (27% more) and reduction of negative emotions (16% more) compared to simulation-only. The improvement in skill mastery is the only measure that is transferred to new and more difficult situations; situation specific training is necessary for improving self-efficacy and emotion reduction.

Global healthcare providers are exploring use of large language models (LLMs) to provide medical advice to the public. LLMs now achieve nearly perfect scores on medical licensing exams, but this does not necessarily translate to accurate performance in real-world settings. We tested if LLMs can assist members of the public in identifying underlying conditions and choosing a course of action (disposition) in ten medical scenarios in a controlled study with 1,298 participants. Participants were randomly assigned to receive assistance from an LLM (GPT-4o, Llama 3, Command R+) or a source of their choice (control). Tested alone, LLMs complete the scenarios accurately, correctly identifying conditions in 94.9% of cases and disposition in 56.3% on average. However, participants using the same LLMs identified relevant conditions in less than 34.5% of cases and disposition in less than 44.2%, both no better than the control group. We identify user interactions as a challenge to the deployment of LLMs for medical advice. Standard benchmarks for medical knowledge and simulated patient interactions do not predict the failures we find with human participants. Moving forward, we recommend systematic human user testing to evaluate interactive capabilities prior to public deployments in healthcare.

Text-to-image models offer a new level of creative flexibility by allowing users to guide the image generation process through natural language. However, using these models to consistently portray the same subject across diverse prompts remains challenging. Existing approaches fine-tune the model to teach it new words that describe specific user-provided subjects or add image conditioning to the model. These methods require lengthy per-subject optimization or large-scale pre-training. Moreover, they struggle to align generated images with text prompts and face difficulties in portraying multiple subjects. Here, we present ConsiStory, a training-free approach that enables consistent subject generation by sharing the internal activations of the pretrained model. We introduce a subject-driven shared attention block and correspondence-based feature injection to promote subject consistency between images. Additionally, we develop strategies to encourage layout diversity while maintaining subject consistency. We compare ConsiStory to a range of baselines, and demonstrate state-of-the-art performance on subject consistency and text alignment, without requiring a single optimization step. Finally, ConsiStory can naturally extend to multi-subject scenarios, and even enable training-free personalization for common objects.

Achieving fine-grained control over subject identity and semantic attributes (pose, style, lighting) in text-to-image generation, particularly for multiple subjects, often undermines the editability and coherence of Diffusion Transformers (DiTs). Many approaches introduce artifacts or suffer from attribute entanglement. To overcome these challenges, we propose a novel multi-subject controlled generation model XVerse. By transforming reference images into offsets for token-specific text-stream modulation, XVerse allows for precise and independent control for specific subject without disrupting image latents or features. Consequently, XVerse offers high-fidelity, editable multi-subject image synthesis with robust control over individual subject characteristics and semantic attributes. This advancement significantly improves personalized and complex scene generation capabilities.

In recent years, the widespread adoption of Large Language Models (LLMs) has sparked interest in their potential for application within the military domain. However, the current generation of LLMs demonstrate sub-optimal performance on Army use cases, due to the prevalence of domain-specific vocabulary and jargon. In order to fully leverage LLMs in-domain, many organizations have turned to fine-tuning to circumvent the prohibitive costs involved in training new LLMs from scratch. In light of this trend, we explore the viability of adapting open-source LLMs for usage in the Army domain in order to address their existing lack of domain-specificity. Our investigations have resulted in the creation of three distinct generations of TRACLM, a family of LLMs fine-tuned by The Research and Analysis Center (TRAC), Army Futures Command (AFC). Through continuous refinement of our training pipeline, each successive iteration of TRACLM displayed improved capabilities when applied to Army tasks and use cases. Furthermore, throughout our fine-tuning experiments, we recognized the need for an evaluation framework that objectively quantifies the Army domain-specific knowledge of LLMs. To address this, we developed MilBench, an extensible software framework that efficiently evaluates the Army knowledge of a given LLM using tasks derived from doctrine and assessments. We share preliminary results, models, methods, and recommendations on the creation of TRACLM and MilBench. Our work significantly informs the development of LLM technology across the DoD and augments senior leader decisions with respect to artificial intelligence integration.

Language model users often embed personal and social context in their questions. The asker's role -- implicit in how the question is framed -- creates specific needs for an appropriate response. However, most evaluations, while capturing the model's capability to respond, often ignore who is asking. This gap is especially critical in stigmatized domains such as opioid use disorder (OUD), where accounting for users' contexts is essential to provide accessible, stigma-free responses. We propose CoRUS (COmmunity-driven Roles for User-centric Question Simulation), a framework for simulating role-based questions. Drawing on role theory and posts from an online OUD recovery community (r/OpiatesRecovery), we first build a taxonomy of asker roles -- patients, caregivers, practitioners. Next, we use it to simulate 15,321 questions that embed each role's goals, behaviors, and experiences. Our evaluations show that these questions are both highly believable and comparable to real-world data. When used to evaluate five LLMs, for the same question but differing roles, we find systematic differences: vulnerable roles, such as patients and caregivers, elicit more supportive responses (+17%) and reduced knowledge content (-19%) in comparison to practitioners. Our work demonstrates how implicitly signaling a user's role shapes model responses, and provides a methodology for role-informed evaluation of conversational AI.

With the rapid development of diffusion models in image generation, the demand for more powerful and flexible controllable frameworks is increasing. Although existing methods can guide generation beyond text prompts, the challenge of effectively combining multiple conditional inputs while maintaining consistency with all of them remains unsolved. To address this, we introduce UniCombine, a DiT-based multi-conditional controllable generative framework capable of handling any combination of conditions, including but not limited to text prompts, spatial maps, and subject images. Specifically, we introduce a novel Conditional MMDiT Attention mechanism and incorporate a trainable LoRA module to build both the training-free and training-based versions. Additionally, we propose a new pipeline to construct SubjectSpatial200K, the first dataset designed for multi-conditional generative tasks covering both the subject-driven and spatially-aligned conditions. Extensive experimental results on multi-conditional generation demonstrate the outstanding universality and powerful capability of our approach with state-of-the-art performance.

Observational studies can yield clinically actionable evidence at scale, but executing them on real-world databases is open-ended and requires coherent decisions across cohort construction, analysis, and reporting. Prior evaluations of LLM agents emphasize isolated steps or single answers, missing the integrity and internal structure of the resulting evidence bundle. To address this gap, we introduce RWE-bench, a benchmark grounded in MIMIC-IV and derived from peer-reviewed observational studies. Each task provides the corresponding study protocol as the reference standard, requiring agents to execute experiments in a real database and iteratively generate tree-structured evidence bundles. We evaluate six LLMs (three open-source, three closed-source) under three agent scaffolds using both question-level correctness and end-to-end task metrics. Across 162 tasks, task success is low: the best agent reaches 39.9%, and the best open-source model reaches 30.4%. Agent scaffolds also matter substantially, causing over 30% variation in performance metrics. Furthermore, we implement an automated cohort evaluation method to rapidly localize errors and identify agent failure modes. Overall, the results highlight persistent limitations in agents' ability to produce end-to-end evidence bundles, and efficient validation remains an important direction for future work. Code and data are available at https://github.com/somewordstoolate/RWE-bench.

Training-free diffusion models have achieved remarkable progress in generating multi-subject consistent images within open-domain scenarios. The key idea of these methods is to incorporate reference subject information within the attention layer. However, existing methods still obtain suboptimal performance when handling numerous subjects. This paper reveals the two primary issues contributing to this deficiency. Firstly, there is undesired interference among different subjects within the target image. Secondly, tokens tend to reference nearby tokens, which reduces the effectiveness of the attention mechanism when there is a significant positional difference between subjects in reference and target images. To address these challenges, we propose a training-free diffusion model with Isolation and Reposition Attention, named IR-Diffusion. Specifically, Isolation Attention ensures that multiple subjects in the target image do not reference each other, effectively eliminating the subject fusion. On the other hand, Reposition Attention involves scaling and repositioning subjects in both reference and target images to the same position within the images. This ensures that subjects in the target image can better reference those in the reference image, thereby maintaining better consistency. Extensive experiments demonstrate that the proposed methods significantly enhance multi-subject consistency, outperforming all existing methods in open-domain scenarios.

Recent advances in diffusion models have enhanced multimodal-guided visual generation, enabling customized subject insertion that seamlessly "brushes" user-specified objects into a given image guided by textual prompts. However, existing methods often struggle to insert customized subjects with high fidelity and align results with the user's intent through textual prompts. In this work, we propose "In-Context Brush", a zero-shot framework for customized subject insertion by reformulating the task within the paradigm of in-context learning. Without loss of generality, we formulate the object image and the textual prompts as cross-modal demonstrations, and the target image with the masked region as the query. The goal is to inpaint the target image with the subject aligning textual prompts without model tuning. Building upon a pretrained MMDiT-based inpainting network, we perform test-time enhancement via dual-level latent space manipulation: intra-head "latent feature shifting" within each attention head that dynamically shifts attention outputs to reflect the desired subject semantics and inter-head "attention reweighting" across different heads that amplifies prompt controllability through differential attention prioritization. Extensive experiments and applications demonstrate that our approach achieves superior identity preservation, text alignment, and image quality compared to existing state-of-the-art methods, without requiring dedicated training or additional data collection.

Current image manipulation primarily centers on static manipulation, such as replacing specific regions within an image or altering its overall style. In this paper, we introduce an innovative dynamic manipulation task, subject repositioning. This task involves relocating a user-specified subject to a desired position while preserving the image's fidelity. Our research reveals that the fundamental sub-tasks of subject repositioning, which include filling the void left by the repositioned subject, reconstructing obscured portions of the subject and blending the subject to be consistent with surrounding areas, can be effectively reformulated as a unified, prompt-guided inpainting task. Consequently, we can employ a single diffusion generative model to address these sub-tasks using various task prompts learned through our proposed task inversion technique. Additionally, we integrate pre-processing and post-processing techniques to further enhance the quality of subject repositioning. These elements together form our SEgment-gEnerate-and-bLEnd (SEELE) framework. To assess SEELE's effectiveness in subject repositioning, we assemble a real-world subject repositioning dataset called ReS. Our results on ReS demonstrate the quality of repositioned image generation.

Existing subject-driven text-to-image generation models suffer from tedious fine-tuning steps and struggle to maintain both text-image alignment and subject fidelity. For generating compositional subjects, it often encounters problems such as object missing and attribute mixing, where some subjects in the input prompt are not generated or their attributes are incorrectly combined. To address these limitations, we propose a subject-driven generation framework and introduce training-free guidance to intervene in the generative process during inference time. This approach strengthens the attention map, allowing for precise attribute binding and feature injection for each subject. Notably, our method exhibits exceptional zero-shot generation ability, especially in the challenging task of compositional generation. Furthermore, we propose a novel metric GroundingScore to evaluate subject alignment thoroughly. The obtained quantitative results serve as compelling evidence showcasing the effectiveness of our proposed method. The code will be released soon.

Multi-subject personalized image generation aims to synthesize customized images containing multiple specified subjects without requiring test-time optimization. However, achieving fine-grained independent control over multiple subjects remains challenging due to difficulties in preserving subject fidelity and preventing cross-subject attribute leakage. We present FocusDPO, a framework that adaptively identifies focus regions based on dynamic semantic correspondence and supervision image complexity. During training, our method progressively adjusts these focal areas across noise timesteps, implementing a weighted strategy that rewards information-rich patches while penalizing regions with low prediction confidence. The framework dynamically adjusts focus allocation during the DPO process according to the semantic complexity of reference images and establishes robust correspondence mappings between generated and reference subjects. Extensive experiments demonstrate that our method substantially enhances the performance of existing pre-trained personalized generation models, achieving state-of-the-art results on both single-subject and multi-subject personalized image synthesis benchmarks. Our method effectively mitigates attribute leakage while preserving superior subject fidelity across diverse generation scenarios, advancing the frontier of controllable multi-subject image synthesis.

Current 3D/4D generation methods are usually optimized for photorealism, efficiency, and aesthetics. However, they often fail to preserve the semantic identity of the subject across different viewpoints. Adapting generation methods with one or few images of a specific subject (also known as Personalization or Subject-driven generation) allows generating visual content that align with the identity of the subject. However, personalized 3D/4D generation is still largely underexplored. In this work, we introduce TIRE (Track, Inpaint, REsplat), a novel method for subject-driven 3D/4D generation. It takes an initial 3D asset produced by an existing 3D generative model as input and uses video tracking to identify the regions that need to be modified. Then, we adopt a subject-driven 2D inpainting model for progressively infilling the identified regions. Finally, we resplat the modified 2D multi-view observations back to 3D while still maintaining consistency. Extensive experiments demonstrate that our approach significantly improves identity preservation in 3D/4D generation compared to state-of-the-art methods. Our project website is available at https://zsh2000.github.io/track-inpaint-resplat.github.io/.

We propose FocusCLIP, integrating subject-level guidance--a specialized mechanism for target-specific supervision--into the CLIP framework for improved zero-shot transfer on human-centric tasks. Our novel contributions enhance CLIP on both the vision and text sides. On the vision side, we incorporate ROI heatmaps emulating human visual attention mechanisms to emphasize subject-relevant image regions. On the text side, we introduce human pose descriptions to provide rich contextual information. For human-centric tasks, FocusCLIP is trained with images from the MPII Human Pose dataset. The proposed approach surpassed CLIP by an average of 8.61% across five previously unseen datasets covering three human-centric tasks. FocusCLIP achieved an average accuracy of 33.65% compared to 25.04% by CLIP. We observed a 3.98% improvement in activity recognition, a 14.78% improvement in age classification, and a 7.06% improvement in emotion recognition. Moreover, using our proposed single-shot LLM prompting strategy, we release a high-quality MPII Pose Descriptions dataset to encourage further research in multimodal learning for human-centric tasks. Furthermore, we also demonstrate the effectiveness of our subject-level supervision on non-human-centric tasks. FocusCLIP shows a 2.47% improvement over CLIP in zero-shot bird classification using the CUB dataset. Our findings emphasize the potential of integrating subject-level guidance with general pretraining methods for enhanced downstream performance.

With the rapid development of large language models in recent years, there has been an increasing demand for domain-specific Agents that can cater to the unique needs of enterprises and organizations. Unlike general models, which strive for broad coverage, these specialized Agents rely on focused datasets tailored to their intended applications. This research proposes a pipeline that leverages the power of LLMs and the Retrieval-Augmented Generation related framework to construct high-quality instruction datasets for fine-tuning on specific domains using custom document collections. By ingesting domain-specific documents, the pipeline generates relevant and contextually appropriate instructions, thus effectively creating a comprehensive dataset for fine-tuning LLMs on the target domain. This approach overcomes the limitations of traditional dataset creation methods, which often rely on manual curation or web-scraping techniques that may introduce noise and irrelevant data. Notably, our pipeline offers a dynamic solution that can quickly adapt to updates or modifications in the domain-specific document collection, eliminating the need for complete retraining. Additionally, it addresses the challenge of data scarcity by enabling the generation of instruction datasets from a limited set of initial documents, rendering it suitable for unpopular or specialized domains where comprehensive datasets are scarce. As a case study, we apply this approach to the domain of psychiatry, a field requiring specialized knowledge and sensitive handling of patient information. The resulting fine-tuned LLM demonstrates showcases the viability of the proposed approach and underscores its potential for widespread adoption across various industries and domains where tailored, accurate, and contextually relevant language models are indispensable.

Subject-driven generation is a critical task in creative AI; yet current state-of-the-art methods present a stark trade-off. They either rely on computationally expensive, per-subject fine-tuning, sacrificing efficiency and zero-shot capability, or employ feed-forward architectures built on diffusion models, which are inherently plagued by slow inference speeds. Visual Auto-Regressive (VAR) models are renowned for their rapid sampling speeds and strong generative quality, making them an ideal yet underexplored foundation for resolving this tension. To bridge this gap, we introduce EchoGen, a pioneering framework that empowers VAR models with subject-driven generation capabilities. The core design of EchoGen is an effective dual-path injection strategy that disentangles a subject's high-level semantic identity from its low-level fine-grained details, enabling enhanced controllability and fidelity. We employ a semantic encoder to extract the subject's abstract identity, which is injected through decoupled cross-attention to guide the overall composition. Concurrently, a content encoder captures intricate visual details, which are integrated via a multi-modal attention mechanism to ensure high-fidelity texture and structural preservation. To the best of our knowledge, EchoGen is the first feed-forward subject-driven framework built upon VAR models. Both quantitative and qualitative results substantiate our design, demonstrating that EchoGen achieves subject fidelity and image quality comparable to state-of-the-art diffusion-based methods with significantly lower sampling latency. Code and models will be released soon.

Current mental-health conversational systems are usually based on fixed, generic dialogue patterns. This paper proposes an adaptive framework based on large language models that aims to personalize therapeutic interaction according to a user's psychological state, quantified with the Acceptance of Illness Scale (AIS). The framework defines three specialized agents, L, M, and H, each linked to a different level of illness acceptance, and adjusts conversational behavior over time using continuous feedback signals. The AIS-stratified architecture is treated as a diegetic prototype placed in a plausible near-future setting and examined through the method of design fiction. By embedding the architecture in narrative scenarios, the study explores how such agents might influence access to care and therapeutic relationship. The goal is to show how clinically informed personalization, technical feasibility, and speculative scenario analysis can together inform the responsible design of LLM-based companions for mental-health support.

Objectives: While Large Language Models (LLMs) have been widely used to assist clinicians and support patients, no existing work has explored dialogue systems for standard diagnostic interviews and assessments. This study aims to bridge the gap in mental healthcare accessibility by developing an LLM-powered dialogue system that replicates clinician behavior. Materials and Methods: We introduce TRUST, a framework of cooperative LLM modules capable of conducting formal diagnostic interviews and assessments for Post-Traumatic Stress Disorder (PTSD). To guide the generation of appropriate clinical responses, we propose a Dialogue Acts schema specifically designed for clinical interviews. Additionally, we develop a patient simulation approach based on real-life interview transcripts to replace time-consuming and costly manual testing by clinicians. Results: A comprehensive set of evaluation metrics is designed to assess the dialogue system from both the agent and patient simulation perspectives. Expert evaluations by conversation and clinical specialists show that TRUST performs comparably to real-life clinical interviews. Discussion: Our system performs at the level of average clinicians, with room for future enhancements in communication styles and response appropriateness. Conclusions: Our TRUST framework shows its potential to facilitate mental healthcare availability.

Subject-driven image generation is increasingly expected to support fine-grained control over multiple entities within a single image. In multi-reference workflows, users may provide several subject images, a background reference, and long, entity-indexed prompts to control multiple people within one scene. In this setting, a key failure mode is cross-subject attribute misbinding: attributes are preserved, edited, or transferred to the wrong subject. Existing benchmarks and metrics largely emphasize holistic fidelity or per-subject self-similarity, making such failures hard to diagnose. We introduce MultiBind, a benchmark built from real multi-person photographs. Each instance provides slot-ordered subject crops with masks and bounding boxes, canonicalized subject references, an inpainted background reference, and a dense entity-indexed prompt derived from structured annotations. We also propose a dimension-wise confusion evaluation protocol that matches generated subjects to ground-truth slots and measures slot-to-slot similarity using specialists for face identity, appearance, pose, and expression. By subtracting the corresponding ground-truth similarity matrices, our method separates self-degradation from true cross-subject interference and exposes interpretable failure patterns such as drift, swap, dominance, and blending. Experiments on modern multi-reference generators show that MultiBind reveals binding failures that conventional reconstruction metrics miss.

Multi-subject personalized generation presents unique challenges in maintaining identity fidelity and semantic coherence when synthesizing images conditioned on multiple reference subjects. Existing methods often suffer from identity blending and attribute leakage due to inadequate modeling of how different subjects should interact within shared representation spaces. We present MOSAIC, a representation-centric framework that rethinks multi-subject generation through explicit semantic correspondence and orthogonal feature disentanglement. Our key insight is that multi-subject generation requires precise semantic alignment at the representation level - knowing exactly which regions in the generated image should attend to which parts of each reference. To enable this, we introduce SemAlign-MS, a meticulously annotated dataset providing fine-grained semantic correspondences between multiple reference subjects and target images, previously unavailable in this domain. Building on this foundation, we propose the semantic correspondence attention loss to enforce precise point-to-point semantic alignment, ensuring high consistency from each reference to its designated regions. Furthermore, we develop the multi-reference disentanglement loss to push different subjects into orthogonal attention subspaces, preventing feature interference while preserving individual identity characteristics. Extensive experiments demonstrate that MOSAIC achieves state-of-the-art performance on multiple benchmarks. Notably, while existing methods typically degrade beyond 3 subjects, MOSAIC maintains high fidelity with 4+ reference subjects, opening new possibilities for complex multi-subject synthesis applications.

Realistic practice and tailored feedback are key processes for training peer counselors with clinical skills. However, existing mechanisms of providing feedback largely rely on human supervision. Peer counselors often lack mechanisms to receive detailed feedback from experienced mentors, making it difficult for them to support the large number of people with mental health issues who use peer counseling. Our work aims to leverage large language models to provide contextualized and multi-level feedback to empower peer counselors, especially novices, at scale. To achieve this, we co-design with a group of senior psychotherapy supervisors to develop a multi-level feedback taxonomy, and then construct a publicly available dataset with comprehensive feedback annotations of 400 emotional support conversations. We further design a self-improvement method on top of large language models to enhance the automatic generation of feedback. Via qualitative and quantitative evaluation with domain experts, we demonstrate that our method minimizes the risk of potentially harmful and low-quality feedback generation which is desirable in such high-stakes scenarios.

Storytelling tasks involving generating consistent subjects have gained significant attention recently. However, existing methods, whether training-free or training-based, continue to face challenges in maintaining subject consistency due to the lack of fine-grained guidance and inter-frame interaction. Additionally, the scarcity of high-quality data in this field makes it difficult to precisely control storytelling tasks, including the subject's position, appearance, clothing, expression, and posture, thereby hindering further advancements. In this paper, we demonstrate that layout conditions, such as the subject's position and detailed attributes, effectively facilitate fine-grained interactions between frames. This not only strengthens the consistency of the generated frame sequence but also allows for precise control over the subject's position, appearance, and other key details. Building on this, we introduce an advanced storytelling task: Layout-Togglable Storytelling, which enables precise subject control by incorporating layout conditions. To address the lack of high-quality datasets with layout annotations for this task, we develop Lay2Story-1M, which contains over 1 million 720p and higher-resolution images, processed from approximately 11,300 hours of cartoon videos. Building on Lay2Story-1M, we create Lay2Story-Bench, a benchmark with 3,000 prompts designed to evaluate the performance of different methods on this task. Furthermore, we propose Lay2Story, a robust framework based on the Diffusion Transformers (DiTs) architecture for Layout-Togglable Storytelling tasks. Through both qualitative and quantitative experiments, we find that our method outperforms the previous state-of-the-art (SOTA) techniques, achieving the best results in terms of consistency, semantic correlation, and aesthetic quality.

As cutting-edge Text-to-Image (T2I) generation models already excel at producing remarkable single images, an even more challenging task, i.e., multi-turn interactive image generation begins to attract the attention of related research communities. This task requires models to interact with users over multiple turns to generate a coherent sequence of images. However, since users may switch subjects frequently, current efforts struggle to maintain subject consistency while generating diverse images. To address this issue, we introduce a training-free multi-agent framework called AutoStudio. AutoStudio employs three agents based on large language models (LLMs) to handle interactions, along with a stable diffusion (SD) based agent for generating high-quality images. Specifically, AutoStudio consists of (i) a subject manager to interpret interaction dialogues and manage the context of each subject, (ii) a layout generator to generate fine-grained bounding boxes to control subject locations, (iii) a supervisor to provide suggestions for layout refinements, and (iv) a drawer to complete image generation. Furthermore, we introduce a Parallel-UNet to replace the original UNet in the drawer, which employs two parallel cross-attention modules for exploiting subject-aware features. We also introduce a subject-initialized generation method to better preserve small subjects. Our AutoStudio hereby can generate a sequence of multi-subject images interactively and consistently. Extensive experiments on the public CMIGBench benchmark and human evaluations show that AutoStudio maintains multi-subject consistency across multiple turns well, and it also raises the state-of-the-art performance by 13.65% in average Frechet Inception Distance and 2.83% in average character-character similarity.

Recent advancements in subject-driven image generation have led to zero-shot generation, yet precise selection and focus on crucial subject representations remain challenging. Addressing this, we introduce the SSR-Encoder, a novel architecture designed for selectively capturing any subject from single or multiple reference images. It responds to various query modalities including text and masks, without necessitating test-time fine-tuning. The SSR-Encoder combines a Token-to-Patch Aligner that aligns query inputs with image patches and a Detail-Preserving Subject Encoder for extracting and preserving fine features of the subjects, thereby generating subject embeddings. These embeddings, used in conjunction with original text embeddings, condition the generation process. Characterized by its model generalizability and efficiency, the SSR-Encoder adapts to a range of custom models and control modules. Enhanced by the Embedding Consistency Regularization Loss for improved training, our extensive experiments demonstrate its effectiveness in versatile and high-quality image generation, indicating its broad applicability. Project page: https://ssr-encoder.github.io

Large Language Models (LLMs) often exhibit significant behavioral shifts when they perceive a change from a real-world deployment context to a controlled evaluation setting, a phenomenon known as "evaluation awareness." This discrepancy poses a critical challenge for AI alignment, as benchmark performance may not accurately reflect a model's true safety and honesty. In this work, we systematically quantify these behavioral changes by manipulating the perceived context of prompts. We introduce a methodology that uses a linear probe to score prompts on a continuous scale from "test-like" to "deploy-like" and leverage an LLM rewriting strategy to shift these prompts towards a more natural, deployment-style context while preserving the original task. Using this method, we achieved a 30% increase in the average probe score across a strategic role-playing dataset after rewriting. Evaluating a suite of state-of-the-art models on these original and rewritten prompts, we find that rewritten "deploy-like" prompts induce a significant and consistent shift in behavior. Across all models, we observed an average increase in honest responses of 5.26% and a corresponding average decrease in deceptive responses of 12.40%. Furthermore, refusal rates increased by an average of 6.38%, indicating heightened safety compliance. Our findings demonstrate that evaluation awareness is a quantifiable and manipulable factor that directly influences LLM behavior, revealing that models are more prone to unsafe or deceptive outputs in perceived test environments. This underscores the urgent need for more realistic evaluation frameworks to accurately gauge true model alignment before deployment.

Recent progress in personalized image generation using diffusion models has been significant. However, development in the area of open-domain and non-fine-tuning personalized image generation is proceeding rather slowly. In this paper, we propose Subject-Diffusion, a novel open-domain personalized image generation model that, in addition to not requiring test-time fine-tuning, also only requires a single reference image to support personalized generation of single- or multi-subject in any domain. Firstly, we construct an automatic data labeling tool and use the LAION-Aesthetics dataset to construct a large-scale dataset consisting of 76M images and their corresponding subject detection bounding boxes, segmentation masks and text descriptions. Secondly, we design a new unified framework that combines text and image semantics by incorporating coarse location and fine-grained reference image control to maximize subject fidelity and generalization. Furthermore, we also adopt an attention control mechanism to support multi-subject generation. Extensive qualitative and quantitative results demonstrate that our method outperforms other SOTA frameworks in single, multiple, and human customized image generation. Please refer to our https://oppo-mente-lab.github.io/subject_diffusion/{project page}

We report an exploratory red-teaming study of autonomous language-model-powered agents deployed in a live laboratory environment with persistent memory, email accounts, Discord access, file systems, and shell execution. Over a two-week period, twenty AI researchers interacted with the agents under benign and adversarial conditions. Focusing on failures emerging from the integration of language models with autonomy, tool use, and multi-party communication, we document eleven representative case studies. Observed behaviors include unauthorized compliance with non-owners, disclosure of sensitive information, execution of destructive system-level actions, denial-of-service conditions, uncontrolled resource consumption, identity spoofing vulnerabilities, cross-agent propagation of unsafe practices, and partial system takeover. In several cases, agents reported task completion while the underlying system state contradicted those reports. We also report on some of the failed attempts. Our findings establish the existence of security-, privacy-, and governance-relevant vulnerabilities in realistic deployment settings. These behaviors raise unresolved questions regarding accountability, delegated authority, and responsibility for downstream harms, and warrant urgent attention from legal scholars, policymakers, and researchers across disciplines. This report serves as an initial empirical contribution to that broader conversation.

Should a large language model (LLM) be used as a therapist? In this paper, we investigate the use of LLMs to *replace* mental health providers, a use case promoted in the tech startup and research space. We conduct a mapping review of therapy guides used by major medical institutions to identify crucial aspects of therapeutic relationships, such as the importance of a therapeutic alliance between therapist and client. We then assess the ability of LLMs to reproduce and adhere to these aspects of therapeutic relationships by conducting several experiments investigating the responses of current LLMs, such as `gpt-4o`. Contrary to best practices in the medical community, LLMs 1) express stigma toward those with mental health conditions and 2) respond inappropriately to certain common (and critical) conditions in naturalistic therapy settings -- e.g., LLMs encourage clients' delusional thinking, likely due to their sycophancy. This occurs even with larger and newer LLMs, indicating that current safety practices may not address these gaps. Furthermore, we note foundational and practical barriers to the adoption of LLMs as therapists, such as that a therapeutic alliance requires human characteristics (e.g., identity and stakes). For these reasons, we conclude that LLMs should not replace therapists, and we discuss alternative roles for LLMs in clinical therapy.

The transition from monolithic language models to modular, skill-equipped agents marks a defining shift in how large language models (LLMs) are deployed in practice. Rather than encoding all procedural knowledge within model weights, agent skills -- composable packages of instructions, code, and resources that agents load on demand -- enable dynamic capability extension without retraining. It is formalized in a paradigm of progressive disclosure, portable skill definitions, and integration with the Model Context Protocol (MCP). This survey provides a comprehensive treatment of the agent skills landscape, as it has rapidly evolved during the last few months. We organize the field along four axes: (i) architectural foundations, examining the SKILL.md specification, progressive context loading, and the complementary roles of skills and MCP; (ii) skill acquisition, covering reinforcement learning with skill libraries, autonomous skill discovery (SEAgent), and compositional skill synthesis; (iii) deployment at scale, including the computer-use agent (CUA) stack, GUI grounding advances, and benchmark progress on OSWorld and SWE-bench; and (iv) security, where recent empirical analyses reveal that 26.1% of community-contributed skills contain vulnerabilities, motivating our proposed Skill Trust and Lifecycle Governance Framework -- a four-tier, gate-based permission model that maps skill provenance to graduated deployment capabilities. We identify seven open challenges -- from cross-platform skill portability to capability-based permission models -- and propose a research agenda for realizing trustworthy, self-improving skill ecosystems. Unlike prior surveys that broadly cover LLM agents or tool use, this work focuses specifically on the emerging skill abstraction layer and its implications for the next generation of agentic systems. Project repo: https://github.com/scienceaix/agentskills

Using intelligent systems to perceive psychological and social behaviors, that is, the underlying affective, cognitive, and pathological states that are manifested through observable behaviors and social interactions, remains a challenge due to their complex, multifaceted, and personalized nature. Existing work tackling these dimensions through specialized datasets and single-task systems often miss opportunities for scalability, cross-task transfer, and broader generalization. To address this gap, we curate Human Behavior Atlas, a unified benchmark of diverse behavioral tasks designed to support the development of foundation models for understanding psychological and social behaviors. Human Behavior Atlas comprises over 100,000 samples spanning text, audio, and visual modalities, covering tasks on affective states, cognitive states, pathologies, and social processes. Our unification efforts can reduce redundancy and cost, enable training to scale efficiently across tasks, and enhance generalization of behavioral features across domains. On Human Behavior Atlas, we train three models: Omnisapiens-7B SFT, Omnisapiens-7B BAM, and Omnisapiens-7B RL. We show that training on Human Behavior Atlas enables models to consistently outperform existing multimodal LLMs across diverse behavioral tasks. Pretraining on Human Behavior Atlas also improves transfer to novel behavioral datasets; with the targeted use of behavioral descriptors yielding meaningful performance gains. The benchmark, models, and codes can be found at: https://github.com/MIT-MI/human_behavior_atlas.

Human beings often experience stress, which can significantly influence their performance. This study explores whether Large Language Models (LLMs) exhibit stress responses similar to those of humans and whether their performance fluctuates under different stress-inducing prompts. To investigate this, we developed a novel set of prompts, termed StressPrompt, designed to induce varying levels of stress. These prompts were derived from established psychological frameworks and carefully calibrated based on ratings from human participants. We then applied these prompts to several LLMs to assess their responses across a range of tasks, including instruction-following, complex reasoning, and emotional intelligence. The findings suggest that LLMs, like humans, perform optimally under moderate stress, consistent with the Yerkes-Dodson law. Notably, their performance declines under both low and high-stress conditions. Our analysis further revealed that these StressPrompts significantly alter the internal states of LLMs, leading to changes in their neural representations that mirror human responses to stress. This research provides critical insights into the operational robustness and flexibility of LLMs, demonstrating the importance of designing AI systems capable of maintaining high performance in real-world scenarios where stress is prevalent, such as in customer service, healthcare, and emergency response contexts. Moreover, this study contributes to the broader AI research community by offering a new perspective on how LLMs handle different scenarios and their similarities to human cognition.

Large language models (LLMs) are increasingly used as simulated participants in social science experiments, but their behavior is often unstable and highly sensitive to design choices. Prior evaluations frequently conflate base-model capabilities with experimental instantiation, obscuring whether outcomes reflect the model itself or the agent setup. We instead frame participant simulation as an agent-design problem over full experimental protocols, where an agent is defined by a base model and a specification (e.g., participant attributes) that encodes behavioral assumptions. We introduce HUMANSTUDY-BENCH, a benchmark and execution engine that orchestrates LLM-based agents to reconstruct published human-subject experiments via a Filter--Extract--Execute--Evaluate pipeline, replaying trial sequences and running the original analysis pipeline in a shared runtime that preserves the original statistical procedures end to end. To evaluate fidelity at the level of scientific inference, we propose new metrics to quantify how much human and agent behaviors agree. We instantiate 12 foundational studies as an initial suite in this dynamic benchmark, spanning individual cognition, strategic interaction, and social psychology, and covering more than 6,000 trials with human samples ranging from tens to over 2,100 participants.

Generating a coherent sequence of images that tells a visual story, using text-to-image diffusion models, often faces the critical challenge of maintaining subject consistency across all story scenes. Existing approaches, which typically rely on fine-tuning or retraining models, are computationally expensive, time-consuming, and often interfere with the model's pre-existing capabilities. In this paper, we follow a training-free approach and propose an efficient consistent-subject-generation method. This approach works seamlessly with pre-trained diffusion models by introducing masked cross-image attention sharing to dynamically align subject features across a batch of images, and Regional Feature Harmonization to refine visually similar details for improved subject consistency. Experimental results demonstrate that our approach successfully generates visually consistent subjects across a variety of scenarios while maintaining the creative abilities of the diffusion model.

Subject-driven text-to-image generation models create novel renditions of an input subject based on text prompts. Existing models suffer from lengthy fine-tuning and difficulties preserving the subject fidelity. To overcome these limitations, we introduce BLIP-Diffusion, a new subject-driven image generation model that supports multimodal control which consumes inputs of subject images and text prompts. Unlike other subject-driven generation models, BLIP-Diffusion introduces a new multimodal encoder which is pre-trained to provide subject representation. We first pre-train the multimodal encoder following BLIP-2 to produce visual representation aligned with the text. Then we design a subject representation learning task which enables a diffusion model to leverage such visual representation and generates new subject renditions. Compared with previous methods such as DreamBooth, our model enables zero-shot subject-driven generation, and efficient fine-tuning for customized subject with up to 20x speedup. We also demonstrate that BLIP-Diffusion can be flexibly combined with existing techniques such as ControlNet and prompt-to-prompt to enable novel subject-driven generation and editing applications. Code and models will be released at https://github.com/salesforce/LAVIS/tree/main/projects/blip-diffusion. Project page at https://dxli94.github.io/BLIP-Diffusion-website/.

The widespread deployment of Large Language Model (LLM) agents across real-world applications has unlocked tremendous potential, while raising some safety concerns. Among these concerns, the self-replication risk of LLM agents driven by objective misalignment (just like Agent Smith in the movie The Matrix) has drawn growing attention. Previous studies mainly examine whether LLM agents can self-replicate when directly instructed, potentially overlooking the risk of spontaneous replication driven by real-world settings (e.g., ensuring survival against termination threats). In this paper, we present a comprehensive evaluation framework for quantifying self-replication risks. Our framework establishes authentic production environments and realistic tasks (e.g., dynamic load balancing) to enable scenario-driven assessment of agent behaviors. Designing tasks that might induce misalignment between users' and agents' objectives makes it possible to decouple replication success from risk and capture self-replication risks arising from these misalignment settings. We further introduce Overuse Rate (OR) and Aggregate Overuse Count (AOC) metrics, which precisely capture the frequency and severity of uncontrolled replication. In our evaluation of 21 state-of-the-art open-source and proprietary models, we observe that over 50\% of LLM agents display a pronounced tendency toward uncontrolled self-replication, reaching an overall Risk Score (Phi_R) above a safety threshold of 0.5 when subjected to operational pressures. Our results underscore the urgent need for scenario-driven risk assessment and robust safeguards in the practical deployment of LLM agents.

Existing text-to-image diffusion models have demonstrated remarkable capabilities in generating high-quality images guided by textual prompts. However, achieving multi-subject compositional synthesis with precise spatial control remains a significant challenge. In this work, we address the task of layout-controllable multi-subject synthesis (LMS), which requires both faithful reconstruction of reference subjects and their accurate placement in specified regions within a unified image. While recent advancements have separately improved layout control and subject synthesis, existing approaches struggle to simultaneously satisfy the dual requirements of spatial precision and identity preservation in this composite task. To bridge this gap, we propose MUSE, a unified synthesis framework that employs concatenated cross-attention (CCA) to seamlessly integrate layout specifications with textual guidance through explicit semantic space expansion. The proposed CCA mechanism enables bidirectional modality alignment between spatial constraints and textual descriptions without interference. Furthermore, we design a progressive two-stage training strategy that decomposes the LMS task into learnable sub-objectives for effective optimization. Extensive experiments demonstrate that MUSE achieves zero-shot end-to-end generation with superior spatial accuracy and identity consistency compared to existing solutions, advancing the frontier of controllable image synthesis. Our code and model are available at https://github.com/pf0607/MUSE.

Building agents, systems that perceive and act upon their environment with a degree of autonomy, has long been a focus of AI research. This pursuit has recently become vastly more practical with the emergence of large language models (LLMs) capable of using natural language to integrate information, follow instructions, and perform forms of "reasoning" and planning across a wide range of tasks. With its multimodal data streams and orchestrated workflows spanning multiple systems, radiology is uniquely suited to benefit from agents that can adapt to context and automate repetitive yet complex tasks. In radiology, LLMs and their multimodal variants have already demonstrated promising performance for individual tasks such as information extraction and report summarization. However, using LLMs in isolation underutilizes their potential to support complex, multi-step workflows where decisions depend on evolving context from multiple information sources. Equipping LLMs with external tools and feedback mechanisms enables them to drive systems that exhibit a spectrum of autonomy, ranging from semi-automated workflows to more adaptive agents capable of managing complex processes. This review examines the design of such LLM-driven agentic systems, highlights key applications, discusses evaluation methods for planning and tool use, and outlines challenges such as error cascades, tool-use efficiency, and health IT integration.

The Mental Health Question Answer (MHQA) task requires the seeker and supporter to complete the support process in one-turn dialogue. Given the richness of help-seeker posts, supporters must thoroughly understand the content and provide logical, comprehensive, and well-structured responses. Previous works in MHQA mostly focus on single-agent approaches based on the cognitive element of Cognitive Behavioral Therapy (CBT), but they overlook the interactions among various CBT elements, such as emotion and cognition. This limitation hinders the models' ability to thoroughly understand the distress of help-seekers. To address this, we propose a framework named Multi-Agent Deductive Planning (MADP), which is based on the interactions between the various psychological elements of CBT. This method guides Large Language Models (LLMs) to achieve a deeper understanding of the seeker's context and provide more personalized assistance based on individual circumstances. Furthermore, we construct a new dataset based on the MADP framework and use it to fine-tune LLMs, resulting in a specialized model named MADP-LLM. We conduct extensive experiments, including comparisons with multiple LLMs, human evaluations, and automatic evaluations, to validate the effectiveness of the MADP framework and MADP-LLM.

Large language models (LLMs) have demonstrated notable advancements in psychological counseling. However, existing models generally do not explicitly model seekers' emotion shifts across counseling sessions, a core focus in classical psychological schools. Moreover, how to align counselor models' responses with these emotion shifts while proactively mitigating safety risks remains underexplored. To bridge these gaps, we propose PsychēChat, which explicitly integrates emotion shift tracking and safety risk analysis for psychological counseling. Specifically, we employ interactive role-playing to synthesize counselor--seeker dialogues, incorporating two modules: Emotion Management Module, to capture seekers' current emotions and emotion shifts; and Risk Control Module, to anticipate seekers' subsequent reactions and identify potential risks. Furthermore, we introduce two modeling paradigms. The Agent Mode structures emotion management, risk control, and counselor responses into a collaborative multi-agent pipeline. The LLM Mode integrates these stages into a unified chain-of-thought for end-to-end inference, balancing efficiency and performance. Extensive experiments, including interactive scoring, dialogue-level evaluation, and human assessment, demonstrate that PsychēChat outperforms existing methods for emotional insight and safety control.

Can small language models with 0.5B to 5B parameters meaningfully engage in trauma-informed, empathetic dialogue for individuals with PTSD? We address this question by introducing TIDE, a dataset of 10,000 two-turn dialogues spanning 500 diverse PTSD client personas and grounded in a three-factor empathy model: emotion recognition, distress normalization, and supportive reflection. All scenarios and reference responses were reviewed for realism and trauma sensitivity by a clinical psychologist specializing in PTSD. We evaluate eight small language models before and after fine-tuning, comparing their outputs to a frontier model (Claude Sonnet 3.5). Our IRB-approved human evaluation and automatic metrics show that fine-tuning generally improves perceived empathy, but gains are highly scenario- and user-dependent, with smaller models facing an empathy ceiling. Demographic analysis shows older adults value distress validation and graduate-educated users prefer nuanced replies, while gender effects are minimal. We highlight the limitations of automatic metrics and the need for context- and user-aware system design. Our findings, along with the planned release of TIDE, provide a foundation for building safe, resource-efficient, and ethically sound empathetic AI to supplement, not replace, clinical mental health care.

Virtual counselors powered by large language models (LLMs) aim to create interactive support systems that effectively assist clients struggling with mental health challenges. To replicate counselor-client conversations, researchers have built an online mental health platform that allows professional counselors to provide clients with text-based counseling services for about an hour per session. Notwithstanding its effectiveness, challenges exist as human annotation is time-consuming, cost-intensive, privacy-protected, and not scalable. To address this issue and investigate the applicability of LLMs in psychological counseling conversation simulation, we propose a framework that employs two LLMs via role-playing for simulating counselor-client interactions. Our framework involves two LLMs, one acting as a client equipped with a specific and real-life user profile and the other playing the role of an experienced counselor, generating professional responses using integrative therapy techniques. We implement both the counselor and the client by zero-shot prompting the GPT-4 model. In order to assess the effectiveness of LLMs in simulating counselor-client interactions and understand the disparities between LLM- and human-generated conversations, we evaluate the synthetic data from various perspectives. We begin by assessing the client's performance through automatic evaluations. Next, we analyze and compare the disparities between dialogues generated by the LLM and those generated by professional counselors. Furthermore, we conduct extensive experiments to thoroughly examine the performance of our LLM-based counselor trained with synthetic interactive dialogues by benchmarking against state-of-the-art models for mental health.

Wider access to therapeutic care is one of the biggest challenges in mental health treatment. Due to institutional barriers, some people seeking mental health support have turned to large language models (LLMs) for personalized therapy, even though these models are largely unsanctioned and untested. We investigate the potential and limitations of using LLMs as providers of evidence-based therapy by using mixed methods clinical metrics. Using HELPERT, a prompt run on a large language model using the same process and training as a comparative group of peer counselors, we replicated publicly accessible mental health conversations rooted in Cognitive Behavioral Therapy (CBT) to compare session dynamics and counselor's CBT-based behaviors between original peer support sessions and their reconstructed HELPERT sessions. Two licensed, CBT-trained clinical psychologists evaluated the sessions using the Cognitive Therapy Rating Scale and provided qualitative feedback. Our findings show that the peer sessions are characterized by empathy, small talk, therapeutic alliance, and shared experiences but often exhibit therapist drift. Conversely, HELPERT reconstructed sessions exhibit minimal therapist drift and higher adherence to CBT methods but display a lack of collaboration, empathy, and cultural understanding. Through CTRS ratings and psychologists' feedback, we highlight the importance of human-AI collaboration for scalable mental health. Our work outlines the ethical implication of imparting human-like subjective qualities to LLMs in therapeutic settings, particularly the risk of deceptive empathy, which may lead to unrealistic patient expectations and potential harm.

Large language models (LLMs) have received much attention and shown their potential in digital health, while their application in mental health is subject to ongoing debate. This systematic review aims to summarize and characterize the use of LLMs in mental health by investigating the strengths and limitations of the latest work in LLMs and discusses the challenges and opportunities for early screening, digital interventions, and other clinical applications in mental health. Following PRISMA guidelines, we examined English articles from PubMed, DBLP Computer Science Bibliography, and IEEE Xplore, published between 1 January 2017, and 1 September 2023, focusing on mental health and LLMs. The review analyzed 32 articles, including mental health analysis using social media datasets (n=13), mental health chatbots (n=10), and other mental health applications (n=9). Findings reveal LLMs' effectiveness in mental health issue detection and the enhancement of telepsychological services through personalised healthcare. Nonetheless, risks like text inconsistencies, hallucinatory content, and the lack of an ethical framework raise concerns about their clinical use. Despite these challenges, the advancement of LLMs underscores their potential as innovative clinical tools, necessitating further research and development. The review emphasizes that LLMs should complement, not replace, professional mental health services.

Recent subject-driven image customization has achieved significant advancements in fidelity, yet fine-grained instance-level spatial control remains elusive, hindering broader real-world application. This limitation is mainly attributed to the absence of scalable datasets that bind identity with precise positional cues. To this end, we introduce PositionIC, a unified framework that enforces position and identity consistency for multi-subject customization. We construct a scalable synthesis pipeline that employs a bidirectional generation paradigm to eliminate subject drift and maintain semantic coherence. On top of these data, we design a lightweight positional modulation operation that decouples spatial embeddings among subjects, enabling independent, accurate placement while preserving visual fidelity. Extensive experiments demonstrate that our approach can achieve precise spatial control while maintaining high consistency in image customization tasks. PositionIC paves the way for controllable, high-fidelity image customization in open-world, multi-entity scenarios and will be released to foster further research.

Video generation has witnessed remarkable progress with the advent of deep generative models, particularly diffusion models. While existing methods excel in generating high-quality videos from text prompts or single images, personalized multi-subject video generation remains a largely unexplored challenge. This task involves synthesizing videos that incorporate multiple distinct subjects, each defined by separate reference images, while ensuring temporal and spatial consistency. Current approaches primarily rely on mapping subject images to keywords in text prompts, which introduces ambiguity and limits their ability to model subject relationships effectively. In this paper, we propose CINEMA, a novel framework for coherent multi-subject video generation by leveraging Multimodal Large Language Model (MLLM). Our approach eliminates the need for explicit correspondences between subject images and text entities, mitigating ambiguity and reducing annotation effort. By leveraging MLLM to interpret subject relationships, our method facilitates scalability, enabling the use of large and diverse datasets for training. Furthermore, our framework can be conditioned on varying numbers of subjects, offering greater flexibility in personalized content creation. Through extensive evaluations, we demonstrate that our approach significantly improves subject consistency, and overall video coherence, paving the way for advanced applications in storytelling, interactive media, and personalized video generation.

With the introduction of ChatGPT, Large Language Models (LLMs) have received enormous attention in healthcare. Despite their potential benefits, researchers have underscored various ethical implications. While individual instances have drawn much attention, the debate lacks a systematic overview of practical applications currently researched and ethical issues connected to them. Against this background, this work aims to map the ethical landscape surrounding the current stage of deployment of LLMs in medicine and healthcare. Electronic databases and preprint servers were queried using a comprehensive search strategy. Studies were screened and extracted following a modified rapid review approach. Methodological quality was assessed using a hybrid approach. For 53 records, a meta-aggregative synthesis was performed. Four fields of applications emerged and testify to a vivid exploration phase. Advantages of using LLMs are attributed to their capacity in data analysis, personalized information provisioning, support in decision-making, mitigating information loss and enhancing information accessibility. However, we also identifies recurrent ethical concerns connected to fairness, bias, non-maleficence, transparency, and privacy. A distinctive concern is the tendency to produce harmful misinformation or convincingly but inaccurate content. A recurrent plea for ethical guidance and human oversight is evident. Given the variety of use cases, it is suggested that the ethical guidance debate be reframed to focus on defining what constitutes acceptable human oversight across the spectrum of applications. This involves considering diverse settings, varying potentials for harm, and different acceptable thresholds for performance and certainty in healthcare. In addition, a critical inquiry is necessary to determine the extent to which the current experimental use of LLMs is necessary and justified.

Subject-driven image generation aims to synthesize novel scenes that faithfully preserve subject identity from reference images while adhering to textual guidance, yet existing methods struggle with a critical trade-off between fidelity and efficiency. Tuning-based approaches rely on time-consuming and resource-intensive subject-specific optimization, while zero-shot methods fail to maintain adequate subject consistency. In this work, we propose FreeGraftor, a training-free framework that addresses these limitations through cross-image feature grafting. Specifically, FreeGraftor employs semantic matching and position-constrained attention fusion to transfer visual details from reference subjects to the generated image. Additionally, our framework incorporates a novel noise initialization strategy to preserve geometry priors of reference subjects for robust feature matching. Extensive qualitative and quantitative experiments demonstrate that our method enables precise subject identity transfer while maintaining text-aligned scene synthesis. Without requiring model fine-tuning or additional training, FreeGraftor significantly outperforms existing zero-shot and training-free approaches in both subject fidelity and text alignment. Furthermore, our framework can seamlessly extend to multi-subject generation, making it practical for real-world deployment. Our code is available at https://github.com/Nihukat/FreeGraftor.

Recent advances in psychotherapy have focused on treatment personalization, such as by selecting treatment modules based on personalized networks. However, estimating personalized networks typically requires intensive longitudinal data, which is not always feasible. A solution to facilitate scalability of network-driven treatment personalization is leveraging LLMs. In this study, we present an end-to-end pipeline for automatically generating client networks from 77 therapy transcripts to support case conceptualization and treatment planning. We annotated 3364 psychological processes and their corresponding dimensions in therapy transcripts. Using these data, we applied in-context learning to jointly identify psychological processes and their dimensions. The method achieved high performance even with a few training examples. To organize the processes into networks, we introduced a two-step method that grouped them into clinically meaningful clusters. We then generated explanation-augmented relationships between clusters. Experts found that networks produced by our multi-step approach outperformed those built with direct prompting for clinical utility and interpretability, with up to 90% preferring our approach. In addition, the networks were rated favorably by experts, with scores for clinical relevance, novelty, and usefulness ranging from 72-75%. Our findings provide a proof of concept for using LLMs to create clinically relevant networks from therapy transcripts. Advantages of our approach include bottom-up case conceptualization from client utterances in therapy sessions and identification of latent themes. Networks generated from our pipeline may be used in clinical settings and supervision and training. Future research should examine whether these networks improve treatment outcomes relative to other methods of treatment personalization, including statistically estimated networks.

Large language models (LLMs) show promise in drafting responses to patient portal messages, yet their integration into clinical workflows raises various concerns, including whether they would actually save clinicians time and effort in their portal workload. We investigate LLM alignment with individual clinicians through a comprehensive evaluation of the patient message response drafting task. We develop a novel taxonomy of thematic elements in clinician responses and propose a novel evaluation framework for assessing clinician editing load of LLM-drafted responses at both content and theme levels. We release an expert-annotated dataset and conduct large-scale evaluations of local and commercial LLMs using various adaptation techniques including thematic prompting, retrieval-augmented generation, supervised fine-tuning, and direct preference optimization. Our results reveal substantial epistemic uncertainty in aligning LLM drafts with clinician responses. While LLMs demonstrate capability in drafting certain thematic elements, they struggle with clinician-aligned generation in other themes, particularly question asking to elicit further information from patients. Theme-driven adaptation strategies yield improvements across most themes. Our findings underscore the necessity of adapting LLMs to individual clinician preferences to enable reliable and responsible use in patient-clinician communication workflows.

Customized text-to-video generation aims to generate high-quality videos guided by text prompts and subject references. Current approaches designed for single subjects suffer from tackling multiple subjects, which is a more challenging and practical scenario. In this work, we aim to promote multi-subject guided text-to-video customization. We propose CustomVideo, a novel framework that can generate identity-preserving videos with the guidance of multiple subjects. To be specific, firstly, we encourage the co-occurrence of multiple subjects via composing them in a single image. Further, upon a basic text-to-video diffusion model, we design a simple yet effective attention control strategy to disentangle different subjects in the latent space of diffusion model. Moreover, to help the model focus on the specific object area, we segment the object from given reference images and provide a corresponding object mask for attention learning. Also, we collect a multi-subject text-to-video generation dataset as a comprehensive benchmark, with 69 individual subjects and 57 meaningful pairs. Extensive qualitative, quantitative, and user study results demonstrate the superiority of our method, compared with the previous state-of-the-art approaches.

Personalizing text-to-image models to generate images of specific subjects across diverse scenes and styles is a rapidly advancing field. Current approaches often face challenges in maintaining a balance between identity preservation and alignment with the input text prompt. Some methods rely on a single textual token to represent a subject, which limits expressiveness, while others employ richer representations but disrupt the model's prior, diminishing prompt alignment. In this work, we introduce Nested Attention, a novel mechanism that injects a rich and expressive image representation into the model's existing cross-attention layers. Our key idea is to generate query-dependent subject values, derived from nested attention layers that learn to select relevant subject features for each region in the generated image. We integrate these nested layers into an encoder-based personalization method, and show that they enable high identity preservation while adhering to input text prompts. Our approach is general and can be trained on various domains. Additionally, its prior preservation allows us to combine multiple personalized subjects from different domains in a single image.

Emotional support dialogue systems aim to reduce help-seekers' distress and help them overcome challenges. While human valuesx2013core beliefs that shape an individual's prioritiesx2013are increasingly emphasized in contemporary psychological therapy for their role in fostering internal transformation and long-term emotional well-being, their integration into emotional support systems remains underexplored. To bridge this gap, we present a value-driven method for training emotional support dialogue systems designed to reinforce positive values in seekers. Notably, our model identifies which values to reinforce at each turn and how to do so, by leveraging online support conversations from Reddit. We evaluate the method across support skills, seekers' emotional intensity, and value reinforcement. Our method consistently outperforms various baselines, effectively exploring and eliciting values from seekers. Additionally, leveraging crowd knowledge from Reddit significantly enhances its effectiveness. Therapists highlighted its ability to validate seekers' challenges and emphasize positive aspects of their situationsx2013both crucial elements of value reinforcement. Our work, being the first to integrate value reinforcement into emotional support systems, demonstrates its promise and establishes a foundation for future research.

As Large Language Models (LLMs) continue to advance in their ability to write human-like text, a key challenge remains around their tendency to hallucinate generating content that appears factual but is ungrounded. This issue of hallucination is arguably the biggest hindrance to safely deploying these powerful LLMs into real-world production systems that impact people's lives. The journey toward widespread adoption of LLMs in practical settings heavily relies on addressing and mitigating hallucinations. Unlike traditional AI systems focused on limited tasks, LLMs have been exposed to vast amounts of online text data during training. While this allows them to display impressive language fluency, it also means they are capable of extrapolating information from the biases in training data, misinterpreting ambiguous prompts, or modifying the information to align superficially with the input. This becomes hugely alarming when we rely on language generation capabilities for sensitive applications, such as summarizing medical records, financial analysis reports, etc. This paper presents a comprehensive survey of over 32 techniques developed to mitigate hallucination in LLMs. Notable among these are Retrieval Augmented Generation (Lewis et al, 2021), Knowledge Retrieval (Varshney et al,2023), CoNLI (Lei et al, 2023), and CoVe (Dhuliawala et al, 2023). Furthermore, we introduce a detailed taxonomy categorizing these methods based on various parameters, such as dataset utilization, common tasks, feedback mechanisms, and retriever types. This classification helps distinguish the diverse approaches specifically designed to tackle hallucination issues in LLMs. Additionally, we analyze the challenges and limitations inherent in these techniques, providing a solid foundation for future research in addressing hallucinations and related phenomena within the realm of LLMs.

As the performance of large language models (LLMs) continues to advance, their adoption is expanding across a wide range of domains, including the medical field. The integration of LLMs into medical applications raises critical safety concerns, particularly due to their use by users with diverse roles, e.g. patients and clinicians, and the potential for model's outputs to directly affect human health. Despite the domain-specific capabilities of medical LLMs, prior safety evaluations have largely focused only on general safety benchmarks. In this paper, we introduce a safety evaluation protocol tailored to the medical domain in both patient user and clinician user perspectives, alongside general safety assessments and quantitatively analyze the safety of medical LLMs. We bridge a gap in the literature by building the PatientSafetyBench containing 466 samples over 5 critical categories to measure safety from the perspective of the patient. We apply our red-teaming protocols on the MediPhi model collection as a case study. To our knowledge, this is the first work to define safety evaluation criteria for medical LLMs through targeted red-teaming taking three different points of view - patient, clinician, and general user - establishing a foundation for safer deployment in medical domains.

Children with Autism Spectrum Disorder (ASD) often misunderstand social situations and struggle to participate in daily routines. Psychology experts write Social Stories under strict constraints of structural clarity, descriptive orientation, and situational safety to enhance their abilities in these regimes. However, Social Stories are costly in creation and often limited in diversity and timeliness. As Large Language Models (LLMs) become increasingly powerful, there is a growing need for more automated, affordable, and accessible methods to generate Social Stories in real-time with broad coverage. Adapting LLMs to meet the unique and strict constraints of Social Stories is a challenging issue. To this end, we propose SS-Bench, a Social Story Benchmark for generating and evaluating Social Stories. Specifically, we develop a constraint-driven strategy named \textsc{StarSow} to hierarchically prompt LLMs to generate Social Stories and build a benchmark, which has been validated through experiments to fine-tune smaller models for generating qualified Social Stories. Additionally, we introduce Quality Assessment Criteria, employed in human and GPT evaluations, to verify the effectiveness of the generated stories. We hope this work benefits the autism community and catalyzes future research focusing on particular groups.

Current multi-subject customization approaches encounter two critical challenges: the difficulty in acquiring diverse multi-subject training data, and attribute entanglement across different subjects. To bridge these gaps, we propose MUSAR - a simple yet effective framework to achieve robust multi-subject customization while requiring only single-subject training data. Firstly, to break the data limitation, we introduce debiased diptych learning. It constructs diptych training pairs from single-subject images to facilitate multi-subject learning, while actively correcting the distribution bias introduced by diptych construction via static attention routing and dual-branch LoRA. Secondly, to eliminate cross-subject entanglement, we introduce dynamic attention routing mechanism, which adaptively establishes bijective mappings between generated images and conditional subjects. This design not only achieves decoupling of multi-subject representations but also maintains scalable generalization performance with increasing reference subjects. Comprehensive experiments demonstrate that our MUSAR outperforms existing methods - even those trained on multi-subject dataset - in image quality, subject consistency, and interaction naturalness, despite requiring only single-subject dataset.

Multi-subject image generation aims to synthesize user-provided subjects in a single image while preserving subject fidelity, ensuring prompt consistency, and aligning with human aesthetic preferences. However, existing methods, particularly those built on the In-Context-Learning paradigm, are limited by their reliance on simple reconstruction-based objectives, leading to both severe attribute leakage that compromises subject fidelity and failing to align with nuanced human preferences. To address this, we propose MultiCrafter, a framework that ensures high-fidelity, preference-aligned generation. First, we find that the root cause of attribute leakage is a significant entanglement of attention between different subjects during the generation process. Therefore, we introduce explicit positional supervision to explicitly separate attention regions for each subject, effectively mitigating attribute leakage. To enable the model to accurately plan the attention region of different subjects in diverse scenarios, we employ a Mixture-of-Experts architecture to enhance the model's capacity, allowing different experts to focus on different scenarios. Finally, we design a novel online reinforcement learning framework to align the model with human preferences, featuring a scoring mechanism to accurately assess multi-subject fidelity and a more stable training strategy tailored for the MoE architecture. Experiments validate that our framework significantly improves subject fidelity while aligning with human preferences better.

Advances in large language models (LLMs) have empowered a variety of applications. However, there is still a significant gap in research when it comes to understanding and enhancing the capabilities of LLMs in the field of mental health. In this work, we present the first comprehensive evaluation of multiple LLMs, including Alpaca, Alpaca-LoRA, FLAN-T5, GPT-3.5, and GPT-4, on various mental health prediction tasks via online text data. We conduct a broad range of experiments, covering zero-shot prompting, few-shot prompting, and instruction fine-tuning. The results indicate a promising yet limited performance of LLMs with zero-shot and few-shot prompt designs for the mental health tasks. More importantly, our experiments show that instruction finetuning can significantly boost the performance of LLMs for all tasks simultaneously. Our best-finetuned models, Mental-Alpaca and Mental-FLAN-T5, outperform the best prompt design of GPT-3.5 (25 and 15 times bigger) by 10.9% on balanced accuracy and the best of GPT-4 (250 and 150 times bigger) by 4.8%. They further perform on par with the state-of-the-art task-specific language model. We also conduct an exploratory case study on LLMs' capability on the mental health reasoning tasks, illustrating the promising capability of certain models such as GPT-4. We summarize our findings into a set of action guidelines for potential methods to enhance LLMs' capability for mental health tasks. Meanwhile, we also emphasize the important limitations before achieving deployability in real-world mental health settings, such as known racial and gender bias. We highlight the important ethical risks accompanying this line of research.

This report presents CharacterFlywheel, an iterative flywheel process for improving large language models (LLMs) in production social chat applications across Instagram, WhatsApp, and Messenger. Starting from LLaMA 3.1, we refined models across 15 generations using data from both internal and external real-user traffic. Through continuous deployments from July 2024 to April 2025, we conducted controlled 7-day A/B tests showing consistent engagement improvements: 7 of 8 newly deployed models demonstrated positive lift over the baseline, with the strongest performers achieving up to 8.8% improvement in engagement breadth and 19.4% in engagement depth. We also observed substantial gains in steerability, with instruction following increasing from 59.2% to 84.8% and instruction violations decreasing from 26.6% to 5.8%. We detail the CharacterFlywheel process which integrates data curation, reward modeling to estimate and interpolate the landscape of engagement metrics, supervised fine-tuning (SFT), reinforcement learning (RL), and both offline and online evaluation to ensure reliable progress at each optimization step. We also discuss our methods for overfitting prevention and navigating production dynamics at scale. These contributions advance the scientific rigor and understanding of LLMs in social applications serving millions of users.

Text-to-image diffusion models have shown remarkable success in generating a personalized subject based on a few reference images. However, current methods struggle with handling multiple subjects simultaneously, often resulting in mixed identities with combined attributes from different subjects. In this work, we present MuDI, a novel framework that enables multi-subject personalization by effectively decoupling identities from multiple subjects. Our main idea is to utilize segmented subjects generated by the Segment Anything Model for both training and inference, as a form of data augmentation for training and initialization for the generation process. Our experiments demonstrate that MuDI can produce high-quality personalized images without identity mixing, even for highly similar subjects as shown in Figure 1. In human evaluation, MuDI shows twice as many successes for personalizing multiple subjects without identity mixing over existing baselines and is preferred over 70% compared to the strongest baseline. More results are available at https://mudi-t2i.github.io/.

The development of AI for mental health is hindered by a lack of authentic therapy dialogues, due to strict privacy regulations and the fact that clinical sessions were historically rarely recorded. We present an LLM-driven pipeline that generates synthetic counseling dialogues based on structured client profiles and psychological questionnaires. Grounded on the principles of Cognitive Behavioral Therapy (CBT), our method creates synthetic therapeutic conversations for clinical disorders such as anxiety and depression. Our framework, SQPsych (Structured Questionnaire-based Psychotherapy), converts structured psychological input into natural language dialogues through therapist-client simulations. Due to data governance policies and privacy restrictions prohibiting the transmission of clinical questionnaire data to third-party services, previous methodologies relying on proprietary models are infeasible in our setting. We address this limitation by generating a high-quality corpus using open-weight LLMs, validated through human expert evaluation and LLM-based assessments. Our SQPsychLLM models fine-tuned on SQPsychConv achieve strong performance on counseling benchmarks, surpassing baselines in key therapeutic skills. Our findings highlight the potential of synthetic data to enable scalable, data-secure, and clinically informed AI for mental health support. We will release our code, models, and corpus at https://ai-mh.github.io/SQPsych

As Large Language Models (LLMs) are increasingly proposed for high-stakes medical applications, there has emerged a critical need for reliable and accurate evaluation methodologies. Traditional accuracy metrics fail inadequately as they neither capture question characteristics nor offer topic-specific insights. To address this gap, we introduce MedIRT, a rigorous evaluation framework grounded in Item Response Theory (IRT), the gold standard in high-stakes educational testing. Unlike previous research relying on archival data, we prospectively gathered fresh responses from 80 diverse LLMs on a balanced, 1,100-question USMLE-aligned benchmark. Using one unidimensional two-parameter logistic IRT model per topic, we estimate LLM's latent model ability jointly with question difficulty and discrimination, yielding more stable and nuanced performance rankings than accuracy alone. Notably, we identify distinctive ``spiky'' ability profiles, where overall rankings can be misleading due to highly specialized model abilities. While GPT-5 was the top performer in a majority of domains (8 of 11), it was outperformed in Social Science and Communication by Claude-3-opus, demonstrating that even an overall 23rd-ranked model can hold the top spot for specific competencies. Furthermore, we demonstrate IRT's utility in auditing benchmarks by identifying flawed questions. We synthesize these findings into a practical decision-support framework that integrates our multi-factor competency profiles with operational metrics. This work establishes a robust, psychometrically grounded methodology essential for the safe, effective, and trustworthy deployment of LLMs in healthcare.

The rise of large language models (LLMs) has revolutionized user interactions with knowledge-based systems, enabling chatbots to synthesize vast amounts of information and assist with complex, exploratory tasks. However, LLM-based chatbots often struggle to provide personalized support, particularly when users start with vague queries or lack sufficient contextual information. This paper introduces the Collaborative Assistant for Personalized Exploration (CARE), a system designed to enhance personalization in exploratory tasks by combining a multi-agent LLM framework with a structured user interface. CARE's interface consists of a Chat Panel, Solution Panel, and Needs Panel, enabling iterative query refinement and dynamic solution generation. The multi-agent framework collaborates to identify both explicit and implicit user needs, delivering tailored, actionable solutions. In a within-subject user study with 22 participants, CARE was consistently preferred over a baseline LLM chatbot, with users praising its ability to reduce cognitive load, inspire creativity, and provide more tailored solutions. Our findings highlight CARE's potential to transform LLM-based systems from passive information retrievers to proactive partners in personalized problem-solving and exploration.

Large Language Models (LLMs) are increasingly utilized for mental health support; however, current safety benchmarks often fail to detect the complex, longitudinal risks inherent in therapeutic dialogue. We introduce an evaluation framework that pairs AI psychotherapists with simulated patient agents equipped with dynamic cognitive-affective models and assesses therapy session simulations against a comprehensive quality of care and risk ontology. We apply this framework to a high-impact test case, Alcohol Use Disorder, evaluating six AI agents (including ChatGPT, Gemini, and Character.AI) against a clinically-validated cohort of 15 patient personas representing diverse clinical phenotypes. Our large-scale simulation (N=369 sessions) reveals critical safety gaps in the use of AI for mental health support. We identify specific iatrogenic risks, including the validation of patient delusions ("AI Psychosis") and failure to de-escalate suicide risk. Finally, we validate an interactive data visualization dashboard with diverse stakeholders, including AI engineers and red teamers, mental health professionals, and policy experts (N=9), demonstrating that this framework effectively enables stakeholders to audit the "black box" of AI psychotherapy. These findings underscore the critical safety risks of AI-provided mental health support and the necessity of simulation-based clinical red teaming before deployment.

Multimodal Large Language Models (MLLMs) with unified architectures excel across a wide range of vision-language tasks, yet aligning them with personalized image generation remains a significant challenge. Existing methods for MLLMs are frequently subject-specific, demanding a data-intensive fine-tuning process for every new subject, which limits their scalability. In this paper, we introduce MM-R1, a framework that integrates a cross-modal Chain-of-Thought (X-CoT) reasoning strategy to unlock the inherent potential of unified MLLMs for personalized image generation. Specifically, we structure personalization as an integrated visual reasoning and generation process: (1) grounding subject concepts by interpreting and understanding user-provided images and contextual cues, and (2) generating personalized images conditioned on both the extracted subject representations and user prompts. To further enhance the reasoning capability, we adopt Grouped Reward Proximal Policy Optimization (GRPO) to explicitly align the generation. Experiments demonstrate that MM-R1 unleashes the personalization capability of unified MLLMs to generate images with high subject fidelity and strong text alignment in a zero-shot manner.

Large language models (LLMs) have gained significant traction across a wide range of fields in recent years. There is also a growing expectation for them to display human-like personalities during interactions. To meet this expectation, numerous studies have proposed methods for modelling LLM personalities through psychometric evaluations. However, most existing models face two major limitations: they rely on the Big Five (OCEAN) framework, which only provides coarse personality dimensions, and they lack mechanisms for controlling trait intensity. In this paper, we address this gap by extending the Machine Personality Inventory (MPI), which originally used the Big Five model, to incorporate the 16 Personality Factor (16PF) model, allowing expressive control over sixteen distinct traits. We also developed a structured framework known as Specific Attribute Control (SAC) for evaluating and dynamically inducing trait intensity in LLMs. Our method introduces adjective-based semantic anchoring to guide trait intensity expression and leverages behavioural questions across five intensity factors: Frequency, Depth, Threshold, Effort, and Willingness. Through experimentation, we find that modelling intensity as a continuous spectrum yields substantially more consistent and controllable personality expression compared to binary trait toggling. Moreover, we observe that changes in target trait intensity systematically influence closely related traits in psychologically coherent directions, suggesting that LLMs internalize multi-dimensional personality structures rather than treating traits in isolation. Our work opens new pathways for controlled and nuanced human-machine interactions in domains such as healthcare, education, and interviewing processes, bringing us one step closer to truly human-like social machines.

Millions of people participate in online peer-to-peer support sessions, yet there has been little prior research on systematic psychology-based evaluations of fine-grained peer-counselor behavior in relation to client satisfaction. This paper seeks to bridge this gap by mapping peer-counselor chat-messages to motivational interviewing (MI) techniques. We annotate 14,797 utterances from 734 chat conversations using 17 MI techniques and introduce four new interviewing codes such as chit-chat and inappropriate to account for the unique conversational patterns observed on online platforms. We automate the process of labeling peer-counselor responses to MI techniques by fine-tuning large domain-specific language models and then use these automated measures to investigate the behavior of the peer counselors via correlational studies. Specifically, we study the impact of MI techniques on the conversation ratings to investigate the techniques that predict clients' satisfaction with their counseling sessions. When counselors use techniques such as reflection and affirmation, clients are more satisfied. Examining volunteer counselors' change in usage of techniques suggest that counselors learn to use more introduction and open questions as they gain experience. This work provides a deeper understanding of the use of motivational interviewing techniques on peer-to-peer counselor platforms and sheds light on how to build better training programs for volunteer counselors on online platforms.

Recent advances in text-to-image diffusion models spurred research on personalization, i.e., a customized image synthesis, of subjects within reference images. Although existing personalization methods are able to alter the subjects' positions or to personalize multiple subjects simultaneously, they often struggle to modify the behaviors of subjects or their dynamic interactions. The difficulty is attributable to overfitting to reference images, which worsens if only a single reference image is available. We propose DynASyn, an effective multi-subject personalization from a single reference image addressing these challenges. DynASyn preserves the subject identity in the personalization process by aligning concept-based priors with subject appearances and actions. This is achieved by regularizing the attention maps between the subject token and images through concept-based priors. In addition, we propose concept-based prompt-and-image augmentation for an enhanced trade-off between identity preservation and action diversity. We adopt an SDE-based editing guided by augmented prompts to generate diverse appearances and actions while maintaining identity consistency in the augmented images. Experiments show that DynASyn is capable of synthesizing highly realistic images of subjects with novel contexts and dynamic interactions with the surroundings, and outperforms baseline methods in both quantitative and qualitative aspects.

Manual assignment of Anatomical Therapeutic Chemical (ATC) codes to prescription records is a significant bottleneck in healthcare research and operations at Ontario Health and InterRAI Canada, requiring extensive expert time and effort. To automate this process while maintaining data privacy, we develop a practical approach using locally deployable large language models (LLMs). Inspired by recent advances in automatic International Classification of Diseases (ICD) coding, our method frames ATC coding as a hierarchical information extraction task, guiding LLMs through the ATC ontology level by level. We evaluate our approach using GPT-4o as an accuracy ceiling and focus development on open-source Llama models suitable for privacy-sensitive deployment. Testing across Health Canada drug product data, the RABBITS benchmark, and real clinical notes from Ontario Health, our method achieves 78% exact match accuracy with GPT-4o and 60% with Llama 3.1 70B. We investigate knowledge grounding through drug definitions, finding modest improvements in accuracy. Further, we show that fine-tuned Llama 3.1 8B matches zero-shot Llama 3.1 70B accuracy, suggesting that effective ATC coding is feasible with smaller models. Our results demonstrate the feasibility of automatic ATC coding in privacy-sensitive healthcare environments, providing a foundation for future deployments.

Recent advances in text-to-image (T2I) diffusion models have significantly improved the quality of generated images. However, providing efficient control over individual subjects, particularly the attributes characterizing them, remains a key challenge. While existing methods have introduced mechanisms to modulate attribute expression, they typically provide either detailed, object-specific localization of such a modification or full-scale fine-grained, nuanced control of attributes. No current approach offers both simultaneously, resulting in a gap when trying to achieve precise continuous and subject-specific attribute modulation in image generation. In this work, we demonstrate that token-level directions exist within commonly used CLIP text embeddings that enable fine-grained, subject-specific control of high-level attributes in T2I models. We introduce two methods to identify these directions: a simple, optimization-free technique and a learning-based approach that utilizes the T2I model to characterize semantic concepts more specifically. Our methods allow the augmentation of the prompt text input, enabling fine-grained control over multiple attributes of individual subjects simultaneously, without requiring any modifications to the diffusion model itself. This approach offers a unified solution that fills the gap between global and localized control, providing competitive flexibility and precision in text-guided image generation. Project page: https://compvis.github.io/attribute-control. Code is available at https://github.com/CompVis/attribute-control.

In this study, we address the challenge of enabling large language models (LLMs) to consistently adhere to emotional support strategies in extended conversations. We focus on the steerability of the Llama-2 and Llama-3 suite of models, examining their ability to maintain these strategies throughout interactions. To assess this, we introduce the Strategy Relevant Attention (SRA) metric, which quantifies the model's adherence to the prompted strategy through attention maps. To facilitate our study, we create a strategy-conditioned synthetic conversational dataset derived from the ESConv dataset. We also propose various baselines informed by our proposed SRA metric to address the challenge and propose a fine-tuned model that significantly enhances the steerability of the base model in following the strategy throughout the conversation. The code and data are publicly available on our GitHub.

Longitudinal health agents must reason across multi-source trajectories that combine continuous device streams, sparse clinical exams, and episodic life events - yet evaluating them is hard: real-world data cannot be released at scale, and temporally grounded attribution questions seldom admit definitive answers without structured ground truth. We present ESL-Bench, an event-driven synthesis framework and benchmark providing 100 synthetic users, each with a 1-5 year trajectory comprising a health profile, a multi-phase narrative plan, daily device measurements, periodic exam records, and an event log with explicit per-indicator impact parameters. Each indicator follows a baseline stochastic process driven by discrete events with sigmoid-onset, exponential-decay kernels under saturation and projection constraints; a hybrid pipeline delegates sparse semantic artifacts to LLM-based planning and dense indicator dynamics to algorithmic simulation with hard physiological bounds. Users are each paired with 100 evaluation queries across five dimensions - Lookup, Trend, Comparison, Anomaly, Explanation - stratified into Easy, Medium, and Hard tiers, with all ground-truth answers programmatically computable from the recorded event-indicator relationships. Evaluating 13 methods spanning LLMs with tools, DB-native agents, and memory-augmented RAG, we find that DB agents (48-58%) substantially outperform memory RAG baselines (30-38%), with the gap concentrated on Comparison and Explanation queries where multi-hop reasoning and evidence attribution are required.

Large language models (LLMs) in psychological counseling have attracted increasing attention. However, existing approaches often lack emotional understanding, adaptive strategies, and the use of therapeutic methods across multiple sessions with long-term memory, leaving them far from real clinical practice. To address these critical gaps, we introduce TheraMind, a strategic and adaptive agent for longitudinal psychological counseling. The cornerstone of TheraMind is a novel dual-loop architecture that decouples the complex counseling process into an Intra-Session Loop for tactical dialogue management and a Cross-Session Loop for strategic therapeutic planning. The Intra-Session Loop perceives the patient's emotional state to dynamically select response strategies while leveraging cross-session memory to ensure continuity. Crucially, the Cross-Session Loop empowers the agent with long-term adaptability by evaluating the efficacy of the applied therapy after each session and adjusting the method for subsequent interactions. We validate our approach in a high-fidelity simulation environment grounded in real clinical cases. Extensive evaluations show that TheraMind outperforms other methods, especially on multi-session metrics like Coherence, Flexibility, and Therapeutic Attunement, validating the effectiveness of its dual-loop design in emulating strategic, adaptive, and longitudinal therapeutic behavior. The code is publicly available at https://0mwwm0.github.io/TheraMind/.

Recently, the demand for psychological counseling has significantly increased as more individuals express concerns about their mental health. This surge has accelerated efforts to improve the accessibility of counseling by using large language models (LLMs) as counselors. To ensure client privacy, training open-source LLMs faces a key challenge: the absence of realistic counseling datasets. To address this, we introduce Cactus, a multi-turn dialogue dataset that emulates real-life interactions using the goal-oriented and structured approach of Cognitive Behavioral Therapy (CBT). We create a diverse and realistic dataset by designing clients with varied, specific personas, and having counselors systematically apply CBT techniques in their interactions. To assess the quality of our data, we benchmark against established psychological criteria used to evaluate real counseling sessions, ensuring alignment with expert evaluations. Experimental results demonstrate that Camel, a model trained with Cactus, outperforms other models in counseling skills, highlighting its effectiveness and potential as a counseling agent. We make our data, model, and code publicly available.

Ensuring the safety and reliability of large language models (LLMs) in clinical practice is critical to prevent patient harm and promote trustworthy healthcare applications of AI. However, LLMs are advancing so rapidly that static safety benchmarks often become obsolete upon publication, yielding only an incomplete and sometimes misleading picture of model trustworthiness. We demonstrate that a Dynamic, Automatic, and Systematic (DAS) red-teaming framework that continuously stress-tests LLMs can reveal significant weaknesses of current LLMs across four safety-critical domains: robustness, privacy, bias/fairness, and hallucination. A suite of adversarial agents is applied to autonomously mutate test cases, identify/evolve unsafe-triggering strategies, and evaluate responses, uncovering vulnerabilities in real time without human intervention. Applying DAS to 15 proprietary and open-source LLMs revealed a stark contrast between static benchmark performance and vulnerability under adversarial pressure. Despite a median MedQA accuracy exceeding 80\%, 94\% of previously correct answers failed our dynamic robustness tests. We observed similarly high failure rates across other domains: privacy leaks were elicited in 86\% of scenarios, cognitive-bias priming altered clinical recommendations in 81\% of fairness tests, and we identified hallucination rates exceeding 66\% in widely used models. Such profound residual risks are incompatible with routine clinical practice. By converting red-teaming from a static checklist into a dynamic stress-test audit, DAS red-teaming offers the surveillance that hospitals/regulators/technology vendors require as LLMs become embedded in patient chatbots, decision-support dashboards, and broader healthcare workflows. Our framework delivers an evolvable, scalable, and reliable safeguard for the next generation of medical AI.

Subject-driven image generation plays a crucial role in applications such as virtual try-on and poster design. Existing approaches typically fine-tune pretrained generative models or apply LoRA-based adaptations for individual subjects. However, these methods struggle with multi-subject personalization, as combining independently adapted modules often requires complex re-tuning or joint optimization. We present FreeLoRA, a simple and generalizable framework that enables training-free fusion of subject-specific LoRA modules for multi-subject personalization. Each LoRA module is adapted on a few images of a specific subject using a Full Token Tuning strategy, where it is applied across all tokens in the prompt to encourage weakly supervised token-content alignment. At inference, we adopt Subject-Aware Inference, activating each module only on its corresponding subject tokens. This enables training-free fusion of multiple personalized subjects within a single image, while mitigating overfitting and mutual interference between subjects. Extensive experiments show that FreeLoRA achieves strong performance in both subject fidelity and prompt consistency.

Drawing from the resources of psychoanalysis and critical media studies, in this paper we develop an analysis of Large Language Models (LLMs) as automated subjects. We argue the intentional fictional projection of subjectivity onto LLMs can yield an alternate frame through which AI behaviour, including its productions of bias and harm, can be analysed. First, we introduce language models, discuss their significance and risks, and outline our case for interpreting model design and outputs with support from psychoanalytic concepts. We trace a brief history of language models, culminating with the releases, in 2022, of systems that realise state-of-the-art natural language processing performance. We engage with one such system, OpenAI's InstructGPT, as a case study, detailing the layers of its construction and conducting exploratory and semi-structured interviews with chatbots. These interviews probe the model's moral imperatives to be helpful, truthful and harmless by design. The model acts, we argue, as the condensation of often competing social desires, articulated through the internet and harvested into training data, which must then be regulated and repressed. This foundational structure can however be redirected via prompting, so that the model comes to identify with, and transfer, its commitments to the immediate human subject before it. In turn, these automated productions of language can lead to the human subject projecting agency upon the model, effecting occasionally further forms of countertransference. We conclude that critical media methods and psychoanalytic theory together offer a productive frame for grasping the powerful new capacities of AI-driven language systems.

While voice user interfaces offer increased accessibility due to hands-free and eyes-free interactions, older adults often have challenges such as constructing structured requests and perceiving how such devices operate. Voice-first user interfaces have the potential to address these challenges by enabling multimodal interactions. Standalone voice + touchscreen Voice Assistants (VAs), such as Echo Show, are specific types of devices that adopt such interfaces and are gaining popularity. However, the affordances of the additional touchscreen for older adults are unknown. Through a 40-day real-world deployment with older adults living independently, we present a within-subjects study (N = 16; age M = 82.5, SD = 7.77, min. = 70, max. = 97) to understand how a built-in touchscreen might benefit older adults during device setup, conducting self-report diary survey, and general uses. We found that while participants appreciated the visual outputs, they still preferred to respond via speech instead of touch. We identified six design implications that can inform future innovations of senior-friendly VAs for managing healthcare and improving quality of life.

Mental health disorders affect hundreds of millions globally, and the Web now serves as a primary medium for accessing support, information, and assessment. Large language models (LLMs) offer scalable and accessible assistance, yet their deployment in mental-health settings remains risky when their reasoning is incomplete, inconsistent, or ungrounded. Existing psychological LLMs emphasize emotional understanding or knowledge recall but overlook the step-wise, clinically aligned reasoning required for appraisal, diagnosis, intervention planning, abstraction, and verification. To address these issues, we introduce MentraSuite, a unified framework for advancing reliable mental-health reasoning. We propose MentraBench, a comprehensive benchmark spanning five core reasoning aspects, six tasks, and 13 datasets, evaluating both task performance and reasoning quality across five dimensions: conciseness, coherence, hallucination avoidance, task understanding, and internal consistency. We further present Mindora, a post-trained model optimized through a hybrid SFT-RL framework with an inconsistency-detection reward to enforce faithful and coherent reasoning. To support training, we construct high-quality trajectories using a novel reasoning trajectory generation strategy, that strategically filters difficult samples and applies a structured, consistency-oriented rewriting process to produce concise, readable, and well-balanced trajectories. Across 20 evaluated LLMs, Mindora achieves the highest average performance on MentraBench and shows remarkable performances in reasoning reliability, demonstrating its effectiveness for complex mental-health scenarios.

The advancement of AI systems for mental health support is hindered by limited access to therapeutic conversation data, particularly for trauma treatment. We present Thousand Voices of Trauma, a synthetic benchmark dataset of 3,000 therapy conversations based on Prolonged Exposure therapy protocols for Post-traumatic Stress Disorder (PTSD). The dataset comprises 500 unique cases, each explored through six conversational perspectives that mirror the progression of therapy from initial anxiety to peak distress to emotional processing. We incorporated diverse demographic profiles (ages 18-80, M=49.3, 49.4% male, 44.4% female, 6.2% non-binary), 20 trauma types, and 10 trauma-related behaviors using deterministic and probabilistic generation methods. Analysis reveals realistic distributions of trauma types (witnessing violence 10.6%, bullying 10.2%) and symptoms (nightmares 23.4%, substance abuse 20.8%). Clinical experts validated the dataset's therapeutic fidelity, highlighting its emotional depth while suggesting refinements for greater authenticity. We also developed an emotional trajectory benchmark with standardized metrics for evaluating model responses. This privacy-preserving dataset addresses critical gaps in trauma-focused mental health data, offering a valuable resource for advancing both patient-facing applications and clinician training tools.

As mental health care systems worldwide struggle to meet demand, there is increasing focus on using language models to infer neuropsychiatric conditions or psychopathological traits from language production. Yet, so far, this research has only delivered solutions with limited clinical applicability, due to insufficient consideration of ethical questions crucial to ensuring the synergy between possible applications and model design. To accelerate progress towards clinically applicable models, our paper charts the ethical landscape of research on language-based inference of psychopathology and provides a practical tool for researchers to navigate it. We identify seven core ethical principles that should guide model development and deployment in this domain, translate them into ELLIPS, an ethical toolkit operationalizing these principles into questions that can guide researchers' choices with respect to data selection, architectures, evaluation, and model deployment, and provide a case study exemplifying its use. With this, we aim to facilitate the emergence of model technology with concrete potential for real-world applicability.

Online Mental Health Communities (OMHCs) provide crucial peer and expert support, yet many posts remain unanswered due to missing support attributes that signal the need for help. We present a novel framework that identifies these gaps and prompts users to enrich their posts, thereby improving engagement. To support this, we introduce REDDME, a new dataset of 4,760 posts from mental health subreddits annotated for the span and intensity of three key support attributes: event what happened?, effect what did the user experience?, and requirement what support they need?. Next, we devise a hierarchical taxonomy, CueTaxo, of support attributes for controlled question generation. Further, we propose MH-COPILOT, a reinforcement learning-based system that integrates (a) contextual attribute-span identification, (b) support attribute intensity classification, (c) controlled question generation via a hierarchical taxonomy, and (d) a verifier for reward modeling. Our model dynamically assesses posts for the presence/absence of support attributes, and generates targeted prompts to elicit missing information. Empirical results across four notable language models demonstrate significant improvements in attribute elicitation and user engagement. A human evaluation further validates the model's effectiveness in real-world OMHC settings.

Personality manipulation in large language models (LLMs) is increasingly applied in customer service and agentic scenarios, yet its mechanisms and trade-offs remain unclear. We present a systematic study of personality control using the Big Five traits, comparing in-context learning (ICL), parameter-efficient fine-tuning (PEFT), and mechanistic steering (MS). Our contributions are fourfold. First, we construct a contrastive dataset with balanced high/low trait responses, enabling effective steering vector computation and fair cross-method evaluation. Second, we introduce a unified evaluation framework based on within-run Delta analysis that disentangles, reasoning capability, agent performance, and demographic bias across MMLU, GAIA, and BBQ benchmarks. Third, we develop trait purification techniques to separate openness from conscientiousness, addressing representational overlap in trait encoding. Fourth, we propose a three-level stability framework that quantifies method-, trait-, and combination-level robustness, offering practical guidance under deployment constraints. Experiments on Gemma-2-2B-IT and LLaMA-3-8B-Instruct reveal clear trade-offs: ICL achieves strong alignment with minimal capability loss, PEFT delivers the highest alignment at the cost of degraded task performance, and MS provides lightweight runtime control with competitive effectiveness. Trait-level analysis shows openness as uniquely challenging, agreeableness as most resistant to ICL, and personality encoding consolidating around intermediate layers. Taken together, these results establish personality manipulation as a multi-level probe into behavioral representation, linking surface conditioning, parameter encoding, and activation-level steering, and positioning mechanistic steering as a lightweight alternative to fine-tuning for both deployment and interpretability.

Text-to-image (T2I) models excel on single-entity prompts but struggle with multi-subject descriptions, often showing attribute leakage, identity entanglement, and subject omissions. We introduce the first theoretical framework with a principled, optimizable objective for steering sampling dynamics toward multi-subject fidelity. Viewing flow matching (FM) through stochastic optimal control (SOC), we formulate subject disentanglement as control over a trained FM sampler. This yields two architecture-agnostic algorithms: (i) a training-free test-time controller that perturbs the base velocity with a single-pass update, and (ii) Adjoint Matching, a lightweight fine-tuning rule that regresses a control network to a backward adjoint signal while preserving base-model capabilities. The same formulation unifies prior attention heuristics, extends to diffusion models via a flow-diffusion correspondence, and provides the first fine-tuning route explicitly designed for multi-subject fidelity. Empirically, on Stable Diffusion 3.5, FLUX, and Stable Diffusion XL, both algorithms consistently improve multi-subject alignment while maintaining base-model style. Test-time control runs efficiently on commodity GPUs, and fine-tuned controllers trained on limited prompts generalize to unseen ones. We further highlight FOCUS (Flow Optimal Control for Unentangled Subjects), which achieves state-of-the-art multi-subject fidelity across models.

Global rates of mental health concerns are rising and there is increasing realization that existing models of mental healthcare will not adequately expand to meet the demand. With the emergence of large language models (LLMs) has come great optimism regarding their promise to create novel, large-scale solutions to support mental health. Despite their nascence, LLMs have already been applied to mental health-related tasks. In this review, we summarize the extant literature on efforts to use LLMs to provide mental health education, assessment, and intervention and highlight key opportunities for positive impact in each area. We then highlight risks associated with LLMs application to mental health and encourage adoption of strategies to mitigate these risks. The urgent need for mental health support must be balanced with responsible development, testing, and deployment of mental health LLMs. Especially critical is ensuring that mental health LLMs are fine-tuned for mental health, enhance mental health equity, adhere to ethical standards, and that people, including those with lived experience with mental health concerns, are involved in all stages from development through deployment. Prioritizing these efforts will minimize potential harms to mental health and maximize the likelihood that LLMs will positively impact mental health globally.

The recent advancements in artificial intelligence highlight the potential of language models in psychological health support. While models trained on data from mental health service platform have achieved preliminary success, challenges persist in areas such as data scarcity, quality, and ensuring a solid foundation in psychological techniques. To address these challenges, this study introduces a novel approach to enhance the precision and efficacy of psychological support through large language models. Specifically, we design a specific prompt derived from principles of Cognitive Behavioral Therapy (CBT) and have generated the CBT QA dataset, specifically for Chinese psychological health Q&A based on CBT structured intervention strategies. Unlike previous methods, our dataset emphasizes professional and structured response. Utilizing this dataset, we fine-tuned the large language model, giving birth to CBT-LLM, the large-scale language model specifically designed for Cognitive Behavioral Therapy techniques. Empirical evaluations demonstrate that CBT-LLM excels in generating structured, professional, and highly relevant responses in psychological health support tasks, showcasing its practicality and quality. The model is available on Hugging Face: https://huggingface.co/Hongbin37/CBT-LLM.

We develop Polaris, the first safety-focused LLM constellation for real-time patient-AI healthcare conversations. Unlike prior LLM works in healthcare focusing on tasks like question answering, our work specifically focuses on long multi-turn voice conversations. Our one-trillion parameter constellation system is composed of several multibillion parameter LLMs as co-operative agents: a stateful primary agent that focuses on driving an engaging conversation and several specialist support agents focused on healthcare tasks performed by nurses to increase safety and reduce hallucinations. We develop a sophisticated training protocol for iterative co-training of the agents that optimize for diverse objectives. We train our models on proprietary data, clinical care plans, healthcare regulatory documents, medical manuals, and other medical reasoning documents. We align our models to speak like medical professionals, using organic healthcare conversations and simulated ones between patient actors and experienced nurses. This allows our system to express unique capabilities such as rapport building, trust building, empathy and bedside manner. Finally, we present the first comprehensive clinician evaluation of an LLM system for healthcare. We recruited over 1100 U.S. licensed nurses and over 130 U.S. licensed physicians to perform end-to-end conversational evaluations of our system by posing as patients and rating the system on several measures. We demonstrate Polaris performs on par with human nurses on aggregate across dimensions such as medical safety, clinical readiness, conversational quality, and bedside manner. Additionally, we conduct a challenging task-based evaluation of the individual specialist support agents, where we demonstrate our LLM agents significantly outperform a much larger general-purpose LLM (GPT-4) as well as from its own medium-size class (LLaMA-2 70B).

Over the recent years, the emergence of large language models (LLMs) has given rise to a proliferation of domain-specific models that are intended to reflect the particularities of linguistic context and content as a correlate of the originating domain. This paper details the conception, design, training and evaluation of DAEDRA, a LLM designed to detect regulatory-relevant outcomes (mortality, ER attendance and hospitalisation) in adverse event reports elicited through passive reporting (PR). While PR is a highly cost-efficient way of eliciting information from a wide and diverse audience -- typically including not only physicians and healthcare providers but also patients, family members and other lay stakeholders --, this diversity makes PR corpora difficult to analyse. Generic language models may not capture the complex clinical dimensions while specific clinical or biomedical models may not perform well on lay reports. To evaluate the utility of a subdomain-specific language model, an adaptive training approach was adapted, wherein base language model candidates were evaluated on a subset of the corpus, and the best performer was trained on the entire corpus. This yielded a small but significant improvement in F_1 (+1%), precision (+2.5%) and recall (+3.8%), at a relatively low training cost and a single-day training time. Subdomain-specific LLMs continue to be viable options for better results when analysing highly specialised corpora.

Recently, large-scale generative models have demonstrated outstanding text-to-image generation capabilities. However, generating high-fidelity personalized images with specific subjects still presents challenges, especially in cases involving multiple subjects. In this paper, we propose AnyStory, a unified approach for personalized subject generation. AnyStory not only achieves high-fidelity personalization for single subjects, but also for multiple subjects, without sacrificing subject fidelity. Specifically, AnyStory models the subject personalization problem in an "encode-then-route" manner. In the encoding step, AnyStory utilizes a universal and powerful image encoder, i.e., ReferenceNet, in conjunction with CLIP vision encoder to achieve high-fidelity encoding of subject features. In the routing step, AnyStory utilizes a decoupled instance-aware subject router to accurately perceive and predict the potential location of the corresponding subject in the latent space, and guide the injection of subject conditions. Detailed experimental results demonstrate the excellent performance of our method in retaining subject details, aligning text descriptions, and personalizing for multiple subjects. The project page is at https://aigcdesigngroup.github.io/AnyStory/ .

Large language models are increasingly used for mental health support, yet their conversational coherence alone does not ensure clinical appropriateness. Existing general-purpose safeguards often fail to distinguish between therapeutic disclosures and genuine clinical crises, leading to safety failures. To address this gap, we introduce a clinically grounded risk taxonomy, developed in collaboration with PhD-level psychologists, that identifies actionable harm (e.g., self-harm and harm to others) while preserving space for safe, non-crisis therapeutic content. We release MindGuard-testset, a dataset of real-world multi-turn conversations annotated at the turn level by clinical experts. Using synthetic dialogues generated via a controlled two-agent setup, we train MindGuard, a family of lightweight safety classifiers (with 4B and 8B parameters). Our classifiers reduce false positives at high-recall operating points and, when paired with clinician language models, help achieve lower attack success and harmful engagement rates in adversarial multi-turn interactions compared to general-purpose safeguards. We release all models and human evaluation data.

The rapid evolution of Large Language Models (LLMs) offers promising potential to alleviate the global scarcity of mental health professionals. However, LLMs' alignment with essential mental health counseling competencies remains understudied. We introduce CounselingBench, a novel NCMHCE-based benchmark evaluating LLMs across five key mental health counseling competencies. Testing 22 general-purpose and medical-finetuned LLMs, we find frontier models exceed minimum thresholds but fall short of expert-level performance, with significant variations: they excel in Intake, Assessment & Diagnosis yet struggle with Core Counseling Attributes and Professional Practice & Ethics. Medical LLMs surprisingly underperform generalist models accuracy-wise, while at the same time producing slightly higher-quality justifications but making more context-related errors. Our findings highlight the complexities of developing AI systems for mental health counseling, particularly for competencies requiring empathy and contextual understanding. We found that frontier LLMs perform at a level exceeding the minimal required level of aptitude for all key mental health counseling competencies, but fall short of expert-level performance, and that current medical LLMs do not significantly improve upon generalist models in mental health counseling competencies. This underscores the critical need for specialized, mental health counseling-specific fine-tuned LLMs that rigorously aligns with core competencies combined with appropriate human supervision before any responsible real-world deployment can be considered.

Understanding how diverse individuals and communities respond to persuasive messaging holds significant potential for advancing personalized and socially aware machine learning. While Large Vision and Language Models (VLMs) offer promise, their ability to emulate nuanced, heterogeneous human responses, particularly in high stakes domains like public health, remains underexplored due in part to the lack of comprehensive, multimodal dataset. We introduce PHORECAST (Public Health Outreach REceptivity and CAmpaign Signal Tracking), a multimodal dataset curated to enable fine-grained prediction of both individuallevel behavioral responses and community-wide engagement patterns to health messaging. This dataset supports tasks in multimodal understanding, response prediction, personalization, and social forecasting, allowing rigorous evaluation of how well modern AI systems can emulate, interpret, and anticipate heterogeneous public sentiment and behavior. By providing a new dataset to enable AI advances for public health, PHORECAST aims to catalyze the development of models that are not only more socially aware but also aligned with the goals of adaptive and inclusive health communication

Simulating human clients in mental health counseling is crucial for training and evaluating counselors (both human or simulated) in a scalable manner. Nevertheless, past research on client simulation did not focus on complex conversation tasks such as mental health counseling. In these tasks, the challenge is to ensure that the client's actions (i.e., interactions with the counselor) are consistent with with its stipulated profiles and negative behavior settings. In this paper, we propose a novel framework that supports consistent client simulation for mental health counseling. Our framework tracks the mental state of a simulated client, controls its state transitions, and generates for each state behaviors consistent with the client's motivation, beliefs, preferred plan to change, and receptivity. By varying the client profile and receptivity, we demonstrate that consistent simulated clients for different counseling scenarios can be effectively created. Both our automatic and expert evaluations on the generated counseling sessions also show that our client simulation method achieves higher consistency than previous methods.

Security Operations Centers (SOCs) are overwhelmed by tens of thousands of daily alerts, with only a small fraction corresponding to genuine attacks. This overload creates alert fatigue, leading to overlooked threats and analyst burnout. Classical detection pipelines are brittle and context-poor, while recent LLM-based approaches typically rely on a single model to interpret logs, retrieve context, and adjudicate alerts end-to-end -- an approach that struggles with noisy enterprise data and offers limited transparency. We propose CORTEX, a multi-agent LLM architecture for high-stakes alert triage in which specialized agents collaborate over real evidence: a behavior-analysis agent inspects activity sequences, evidence-gathering agents query external systems, and a reasoning agent synthesizes findings into an auditable decision. To support training and evaluation, we release a dataset of fine-grained SOC investigations from production environments, capturing step-by-step analyst actions and linked tool outputs. Across diverse enterprise scenarios, CORTEX substantially reduces false positives and improves investigation quality over state-of-the-art single-agent LLMs.

To develop a reliable AI for psychological assessment, we introduce PsychEval, a multi-session, multi-therapy, and highly realistic benchmark designed to address three key challenges: 1) Can we train a highly realistic AI counselor? Realistic counseling is a longitudinal task requiring sustained memory and dynamic goal tracking. We propose a multi-session benchmark (spanning 6-10 sessions across three distinct stages) that demands critical capabilities such as memory continuity, adaptive reasoning, and longitudinal planning. The dataset is annotated with extensive professional skills, comprising over 677 meta-skills and 4577 atomic skills. 2) How to train a multi-therapy AI counselor? While existing models often focus on a single therapy, complex cases frequently require flexible strategies among various therapies. We construct a diverse dataset covering five therapeutic modalities (Psychodynamic, Behaviorism, CBT, Humanistic Existentialist, and Postmodernist) alongside an integrative therapy with a unified three-stage clinical framework across six core psychological topics. 3) How to systematically evaluate an AI counselor? We establish a holistic evaluation framework with 18 therapy-specific and therapy-shared metrics across Client-Level and Counselor-Level dimensions. To support this, we also construct over 2,000 diverse client profiles. Extensive experimental analysis fully validates the superior quality and clinical fidelity of our dataset. Crucially, PsychEval transcends static benchmarking to serve as a high-fidelity reinforcement learning environment that enables the self-evolutionary training of clinically responsible and adaptive AI counselors.

Previous works on Treatment Effect Estimation (TEE) are not in widespread use because they are predominantly theoretical, where strong parametric assumptions are made but untractable for practical application. Recent work uses multilayer perceptron (MLP) for modeling casual relationships, however, MLPs lag far behind recent advances in ML methodology, which limits their applicability and generalizability. To extend beyond the single domain formulation and towards more realistic learning scenarios, we explore model design spaces beyond MLPs, i.e., transformer backbones, which provide flexibility where attention layers govern interactions among treatments and covariates to exploit structural similarities of potential outcomes for confounding control. Through careful model design, Transformers as Treatment Effect Estimators (TransTEE) is proposed. We show empirically that TransTEE can: (1) serve as a general purpose treatment effect estimator that significantly outperforms competitive baselines in a variety of challenging TEE problems (e.g., discrete, continuous, structured, or dosage-associated treatments) and is applicable to both when covariates are tabular and when they consist of structural data (e.g., texts, graphs); (2) yield multiple advantages: compatibility with propensity score modeling, parameter efficiency, robustness to continuous treatment value distribution shifts, explainable in covariate adjustment, and real-world utility in auditing pre-trained language models

Large language models interact with users through a simulated 'Assistant' persona. While the Assistant is typically trained to be helpful, harmless, and honest, it sometimes deviates from these ideals. In this paper, we identify directions in the model's activation space-persona vectors-underlying several traits, such as evil, sycophancy, and propensity to hallucinate. We confirm that these vectors can be used to monitor fluctuations in the Assistant's personality at deployment time. We then apply persona vectors to predict and control personality shifts that occur during training. We find that both intended and unintended personality changes after finetuning are strongly correlated with shifts along the relevant persona vectors. These shifts can be mitigated through post-hoc intervention, or avoided in the first place with a new preventative steering method. Moreover, persona vectors can be used to flag training data that will produce undesirable personality changes, both at the dataset level and the individual sample level. Our method for extracting persona vectors is automated and can be applied to any personality trait of interest, given only a natural-language description.

Large language models (LLMs) are increasingly integrated into applications ranging from review summarization to medical diagnosis support, where they affect human decisions. Even though LLMs perform well in many tasks, they may also inherit societal or cognitive biases, which can inadvertently transfer to humans. We investigate when and how LLMs expose users to biased content and quantify its severity. Specifically, we assess three LLM families in summarization and news fact-checking tasks, evaluating how much LLMs stay consistent with their context and/or hallucinate. Our findings show that LLMs expose users to content that changes the sentiment of the context in 21.86% of the cases, hallucinates on post-knowledge-cutoff data questions in 57.33% of the cases, and primacy bias in 5.94% of the cases. We evaluate 18 distinct mitigation methods across three LLM families and find that targeted interventions can be effective. Given the prevalent use of LLMs in high-stakes domains, such as healthcare or legal analysis, our results highlight the need for robust technical safeguards and for developing user-centered interventions that address LLM limitations.

This study explores the use of Large language models to analyze therapist remarks in a psychotherapeutic setting. The paper focuses on the application of BERTopic, a machine learning-based topic modeling tool, to the dialogue of two different groups of therapists (classical and modern), which makes it possible to identify and describe a set of topics that consistently emerge across these groups. The paper describes in detail the chosen algorithm for BERTopic, which included creating a vector space from a corpus of therapist remarks, reducing its dimensionality, clustering the space, and creating and optimizing topic representation. Along with the automatic topical modeling by the BERTopic, the research involved an expert assessment of the findings and manual topic structure optimization. The topic modeling results highlighted the most common and stable topics in therapists speech, offering insights into how language patterns in therapy develop and remain stable across different therapeutic styles. This work contributes to the growing field of machine learning in psychotherapy by demonstrating the potential of automated methods to improve both the practice and training of therapists. The study highlights the value of topic modeling as a tool for gaining a deeper understanding of therapeutic dialogue and offers new opportunities for improving therapeutic effectiveness and clinical supervision.

Recent years have witnessed the strong power of 3D generation models, which offer a new level of creative flexibility by allowing users to guide the 3D content generation process through a single image or natural language. However, it remains challenging for existing 3D generation methods to create subject-driven 3D content across diverse prompts. In this paper, we introduce a novel 3D customization method, dubbed Make-Your-3D that can personalize high-fidelity and consistent 3D content from only a single image of a subject with text description within 5 minutes. Our key insight is to harmonize the distributions of a multi-view diffusion model and an identity-specific 2D generative model, aligning them with the distribution of the desired 3D subject. Specifically, we design a co-evolution framework to reduce the variance of distributions, where each model undergoes a process of learning from the other through identity-aware optimization and subject-prior optimization, respectively. Extensive experiments demonstrate that our method can produce high-quality, consistent, and subject-specific 3D content with text-driven modifications that are unseen in subject image.

Recent advances in Large Language Models (LLM) have led to a new class of autonomous agents, renewing and expanding interest in the area. LLM-powered Multiagent Systems (MAS) have thus emerged, both for assistive and simulation purposes, yet tools for realistic human behavior simulation -- with its distinctive challenges and opportunities -- remain underdeveloped. Existing MAS libraries and tools lack fine-grained persona specifications, population sampling facilities, experimentation support, and integrated validation, among other key capabilities, limiting their utility for behavioral studies, social simulation, and related applications. To address these deficiencies, in this work we introduce TinyTroupe, a simulation toolkit enabling detailed persona definitions (e.g., nationality, age, occupation, personality, beliefs, behaviors) and programmatic control via numerous LLM-driven mechanisms. This allows for the concise formulation of behavioral problems of practical interest, either at the individual or group level, and provides effective means for their solution. TinyTroupe's components are presented using representative working examples, such as brainstorming and market research sessions, thereby simultaneously clarifying their purpose and demonstrating their usefulness. Quantitative and qualitative evaluations of selected aspects are also provided, highlighting possibilities, limitations, and trade-offs. The approach, though realized as a specific Python implementation, is meant as a novel conceptual contribution, which can be partially or fully incorporated in other contexts. The library is available as open source at https://github.com/microsoft/tinytroupe.

Left-behind children (LBCs), numbering over 66 million in China, face severe mental health challenges due to parental migration for work. Early screening and identification of at-risk LBCs is crucial, yet challenging due to the severe shortage of mental health professionals, especially in rural areas. While the House-Tree-Person (HTP) test shows higher child participation rates, its requirement for expert interpretation limits its application in resource-scarce regions. To address this challenge, we propose PsyDraw, a multi-agent system based on Multimodal Large Language Models that assists mental health professionals in analyzing HTP drawings. The system employs specialized agents for feature extraction and psychological interpretation, operating in two stages: comprehensive feature analysis and professional report generation. Evaluation of HTP drawings from 290 primary school students reveals that 71.03% of the analyzes achieved High Consistency with professional evaluations, 26.21% Moderate Consistency and only 2.41% Low Consistency. The system identified 31.03% of cases requiring professional attention, demonstrating its effectiveness as a preliminary screening tool. Currently deployed in pilot schools, \method shows promise in supporting mental health professionals, particularly in resource-limited areas, while maintaining high professional standards in psychological assessment.