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Apr 17

From shape to fate: making bacterial swarming expansion predictable

Microbial swarming on mucosal surfaces reshapes microbial communities and influences mucosal healing and antibiotic tolerance. Yet even with time-lapse microscopy and deep learning, analyses of swarming colonies remain descriptive and cannot forecast how their fronts reorganize in time. This limitation is significant because the advancing edge determines access to nutrients, host tissue and competing microbes. We recast the expansion of Enterobacter sp. SM3 swarms as a problem of morphological forecasting, and assemble SwarmEvo, a time-lapse dataset represented as boundary-resolved segmentations. TexPol--Net, a texture- and geometry-aware segmentation model, sharpens diffuse edges and preserves fingered fronts, creating a stable substrate for dynamics. On this representation, we develop Morpher, an autoregressive forecasting network with a ``Morphon'' memory that links local curvature to long-range temporal dependencies. Morpher outperforms leading video-prediction models in maintaining front localization and anisotropic branching, and modest segmentation improvements yield noticeably more stable forecasts. Ablations across sequence models, inference strategies and observation ratios show that attention-based architectures with structural memory best preserve dense-finger propagation. By uniting geometry-aware segmentation with morphology-level forecasting, this framework turns swarming expansion into a predictive dynamical system, enabling quantitative interrogation and potential control of microbial collectives during mucosal repair and gut ecosystem engineering.

  • 8 authors
·
Feb 1

Towards Early Prediction of Human iPSC Reprogramming Success

This paper presents advancements in automated early-stage prediction of the success of reprogramming human induced pluripotent stem cells (iPSCs) as a potential source for regenerative cell therapies.The minuscule success rate of iPSC-reprogramming of around 0.01% to 0.1% makes it labor-intensive, time-consuming, and exorbitantly expensive to generate a stable iPSC line. Since that requires culturing of millions of cells and intense biological scrutiny of multiple clones to identify a single optimal clone. The ability to reliably predict which cells are likely to establish as an optimal iPSC line at an early stage of pluripotency would therefore be ground-breaking in rendering this a practical and cost-effective approach to personalized medicine. Temporal information about changes in cellular appearance over time is crucial for predicting its future growth outcomes. In order to generate this data, we first performed continuous time-lapse imaging of iPSCs in culture using an ultra-high resolution microscope. We then annotated the locations and identities of cells in late-stage images where reliable manual identification is possible. Next, we propagated these labels backwards in time using a semi-automated tracking system to obtain labels for early stages of growth. Finally, we used this data to train deep neural networks to perform automatic cell segmentation and classification. Our code and data are available at https://github.com/abhineet123/ipsc_prediction.

  • 6 authors
·
May 23, 2023

ChronoMagic-Bench: A Benchmark for Metamorphic Evaluation of Text-to-Time-lapse Video Generation

We propose a novel text-to-video (T2V) generation benchmark, ChronoMagic-Bench, to evaluate the temporal and metamorphic capabilities of the T2V models (e.g. Sora and Lumiere) in time-lapse video generation. In contrast to existing benchmarks that focus on the visual quality and textual relevance of generated videos, ChronoMagic-Bench focuses on the model's ability to generate time-lapse videos with significant metamorphic amplitude and temporal coherence. The benchmark probes T2V models for their physics, biology, and chemistry capabilities, in a free-form text query. For these purposes, ChronoMagic-Bench introduces 1,649 prompts and real-world videos as references, categorized into four major types of time-lapse videos: biological, human-created, meteorological, and physical phenomena, which are further divided into 75 subcategories. This categorization comprehensively evaluates the model's capacity to handle diverse and complex transformations. To accurately align human preference with the benchmark, we introduce two new automatic metrics, MTScore and CHScore, to evaluate the videos' metamorphic attributes and temporal coherence. MTScore measures the metamorphic amplitude, reflecting the degree of change over time, while CHScore assesses the temporal coherence, ensuring the generated videos maintain logical progression and continuity. Based on the ChronoMagic-Bench, we conduct comprehensive manual evaluations of ten representative T2V models, revealing their strengths and weaknesses across different categories of prompts, and providing a thorough evaluation framework that addresses current gaps in video generation research. Moreover, we create a large-scale ChronoMagic-Pro dataset, containing 460k high-quality pairs of 720p time-lapse videos and detailed captions ensuring high physical pertinence and large metamorphic amplitude.

  • 10 authors
·
Jun 26, 2024 3

MagicTime: Time-lapse Video Generation Models as Metamorphic Simulators

Recent advances in Text-to-Video generation (T2V) have achieved remarkable success in synthesizing high-quality general videos from textual descriptions. A largely overlooked problem in T2V is that existing models have not adequately encoded physical knowledge of the real world, thus generated videos tend to have limited motion and poor variations. In this paper, we propose MagicTime, a metamorphic time-lapse video generation model, which learns real-world physics knowledge from time-lapse videos and implements metamorphic generation. First, we design a MagicAdapter scheme to decouple spatial and temporal training, encode more physical knowledge from metamorphic videos, and transform pre-trained T2V models to generate metamorphic videos. Second, we introduce a Dynamic Frames Extraction strategy to adapt to metamorphic time-lapse videos, which have a wider variation range and cover dramatic object metamorphic processes, thus embodying more physical knowledge than general videos. Finally, we introduce a Magic Text-Encoder to improve the understanding of metamorphic video prompts. Furthermore, we create a time-lapse video-text dataset called ChronoMagic, specifically curated to unlock the metamorphic video generation ability. Extensive experiments demonstrate the superiority and effectiveness of MagicTime for generating high-quality and dynamic metamorphic videos, suggesting time-lapse video generation is a promising path toward building metamorphic simulators of the physical world.

  • 9 authors
·
Apr 7, 2024 2

The TYC Dataset for Understanding Instance-Level Semantics and Motions of Cells in Microstructures

Segmenting cells and tracking their motion over time is a common task in biomedical applications. However, predicting accurate instance-wise segmentation and cell motions from microscopy imagery remains a challenging task. Using microstructured environments for analyzing single cells in a constant flow of media adds additional complexity. While large-scale labeled microscopy datasets are available, we are not aware of any large-scale dataset, including both cells and microstructures. In this paper, we introduce the trapped yeast cell (TYC) dataset, a novel dataset for understanding instance-level semantics and motions of cells in microstructures. We release 105 dense annotated high-resolution brightfield microscopy images, including about 19k instance masks. We also release 261 curated video clips composed of 1293 high-resolution microscopy images to facilitate unsupervised understanding of cell motions and morphology. TYC offers ten times more instance annotations than the previously largest dataset, including cells and microstructures. Our effort also exceeds previous attempts in terms of microstructure variability, resolution, complexity, and capturing device (microscopy) variability. We facilitate a unified comparison on our novel dataset by introducing a standardized evaluation strategy. TYC and evaluation code are publicly available under CC BY 4.0 license.

  • 3 authors
·
Aug 23, 2023

DropletVideo: A Dataset and Approach to Explore Integral Spatio-Temporal Consistent Video Generation

Spatio-temporal consistency is a critical research topic in video generation. A qualified generated video segment must ensure plot plausibility and coherence while maintaining visual consistency of objects and scenes across varying viewpoints. Prior research, especially in open-source projects, primarily focuses on either temporal or spatial consistency, or their basic combination, such as appending a description of a camera movement after a prompt without constraining the outcomes of this movement. However, camera movement may introduce new objects to the scene or eliminate existing ones, thereby overlaying and affecting the preceding narrative. Especially in videos with numerous camera movements, the interplay between multiple plots becomes increasingly complex. This paper introduces and examines integral spatio-temporal consistency, considering the synergy between plot progression and camera techniques, and the long-term impact of prior content on subsequent generation. Our research encompasses dataset construction through to the development of the model. Initially, we constructed a DropletVideo-10M dataset, which comprises 10 million videos featuring dynamic camera motion and object actions. Each video is annotated with an average caption of 206 words, detailing various camera movements and plot developments. Following this, we developed and trained the DropletVideo model, which excels in preserving spatio-temporal coherence during video generation. The DropletVideo dataset and model are accessible at https://dropletx.github.io.

  • 13 authors
·
Mar 7, 2025 2

SpaceTimePilot: Generative Rendering of Dynamic Scenes Across Space and Time

We present SpaceTimePilot, a video diffusion model that disentangles space and time for controllable generative rendering. Given a monocular video, SpaceTimePilot can independently alter the camera viewpoint and the motion sequence within the generative process, re-rendering the scene for continuous and arbitrary exploration across space and time. To achieve this, we introduce an effective animation time-embedding mechanism in the diffusion process, allowing explicit control of the output video's motion sequence with respect to that of the source video. As no datasets provide paired videos of the same dynamic scene with continuous temporal variations, we propose a simple yet effective temporal-warping training scheme that repurposes existing multi-view datasets to mimic temporal differences. This strategy effectively supervises the model to learn temporal control and achieve robust space-time disentanglement. To further enhance the precision of dual control, we introduce two additional components: an improved camera-conditioning mechanism that allows altering the camera from the first frame, and CamxTime, the first synthetic space-and-time full-coverage rendering dataset that provides fully free space-time video trajectories within a scene. Joint training on the temporal-warping scheme and the CamxTime dataset yields more precise temporal control. We evaluate SpaceTimePilot on both real-world and synthetic data, demonstrating clear space-time disentanglement and strong results compared to prior work. Project page: https://zheninghuang.github.io/Space-Time-Pilot/ Code: https://github.com/ZheningHuang/spacetimepilot

  • 7 authors
·
Dec 31, 2025 2

DTVNet+: A High-Resolution Scenic Dataset for Dynamic Time-lapse Video Generation

This paper presents a novel end-to-end dynamic time-lapse video generation framework, named DTVNet, to generate diversified time-lapse videos from a single landscape image conditioned on normalized motion vectors. The proposed DTVNet consists of two submodules: Optical Flow Encoder (OFE) and Dynamic Video Generator (DVG). The OFE maps a sequence of optical flow maps to a normalized motion vector that encodes the motion information of the generated video. The DVG contains motion and content streams to learn from the motion vector and the single landscape image. Besides, it contains an encoder to learn shared content features and a decoder to construct video frames with corresponding motion. Specifically, the motion stream introduces multiple adaptive instance normalization (AdaIN) layers to integrate multi-level motion information for controlling the object motion. In the testing stage, videos with the same content but various motion information can be generated by different normalized motion vectors based on only one input image. Also, we propose a high-resolution scenic time-lapse video dataset, named Quick-Sky-Time, to evaluate different approaches, which can be viewed as a new benchmark for high-quality scenic image and video generation tasks. We further conduct experiments on Sky Time-lapse, Beach, and Quick-Sky-Time datasets. The results demonstrate the superiority of our approach over state-of-the-art methods for generating high-quality and various dynamic videos.

  • 4 authors
·
Aug 11, 2020

Temporal Feature Matters: A Framework for Diffusion Model Quantization

The Diffusion models, widely used for image generation, face significant challenges related to their broad applicability due to prolonged inference times and high memory demands. Efficient Post-Training Quantization (PTQ) is crucial to address these issues. However, unlike traditional models, diffusion models critically rely on the time-step for the multi-round denoising. Typically, each time-step is encoded into a hypersensitive temporal feature by several modules. Despite this, existing PTQ methods do not optimize these modules individually. Instead, they employ unsuitable reconstruction objectives and complex calibration methods, leading to significant disturbances in the temporal feature and denoising trajectory, as well as reduced compression efficiency. To address these challenges, we introduce a novel quantization framework that includes three strategies: 1) TIB-based Maintenance: Based on our innovative Temporal Information Block (TIB) definition, Temporal Information-aware Reconstruction (TIAR) and Finite Set Calibration (FSC) are developed to efficiently align original temporal features. 2) Cache-based Maintenance: Instead of indirect and complex optimization for the related modules, pre-computing and caching quantized counterparts of temporal features are developed to minimize errors. 3) Disturbance-aware Selection: Employ temporal feature errors to guide a fine-grained selection between the two maintenance strategies for further disturbance reduction. This framework preserves most of the temporal information and ensures high-quality end-to-end generation. Extensive testing on various datasets, diffusion models and hardware confirms our superior performance and acceleration..

  • 7 authors
·
Jul 28, 2024

KFFocus: Highlighting Keyframes for Enhanced Video Understanding

Recently, with the emergence of large language models, multimodal LLMs have demonstrated exceptional capabilities in image and video modalities. Despite advancements in video comprehension, the substantial computational demands of long video sequences lead current video LLMs (Vid-LLMs) to employ compression strategies at both the inter-frame level (e.g., uniform sampling of video frames) and intra-frame level (e.g., condensing all visual tokens of each frame into a limited number). However, this approach often neglects the uneven temporal distribution of critical information across frames, risking the omission of keyframes that contain essential temporal and semantic details. To tackle these challenges, we propose KFFocus, a method designed to efficiently compress video tokens and emphasize the informative context present within video frames. We substitute uniform sampling with a refined approach inspired by classic video compression principles to identify and capture keyframes based on their temporal redundancy. By assigning varying condensation ratios to frames based on their contextual relevance, KFFocus efficiently reduces token redundancy while preserving informative content details. Additionally, we introduce a spatiotemporal modeling module that encodes both the temporal relationships between video frames and the spatial structure within each frame, thus providing Vid-LLMs with a nuanced understanding of spatial-temporal dynamics. Extensive experiments on widely recognized video understanding benchmarks, especially long video scenarios, demonstrate that KFFocus significantly outperforms existing methods, achieving substantial computational efficiency and enhanced accuracy.

  • 4 authors
·
Aug 12, 2025

HR-INR: Continuous Space-Time Video Super-Resolution via Event Camera

Continuous space-time video super-resolution (C-STVSR) aims to simultaneously enhance video resolution and frame rate at an arbitrary scale. Recently, implicit neural representation (INR) has been applied to video restoration, representing videos as implicit fields that can be decoded at an arbitrary scale. However, the highly ill-posed nature of C-STVSR limits the effectiveness of current INR-based methods: they assume linear motion between frames and use interpolation or feature warping to generate features at arbitrary spatiotemporal positions with two consecutive frames. This restrains C-STVSR from capturing rapid and nonlinear motion and long-term dependencies (involving more than two frames) in complex dynamic scenes. In this paper, we propose a novel C-STVSR framework, called HR-INR, which captures both holistic dependencies and regional motions based on INR. It is assisted by an event camera, a novel sensor renowned for its high temporal resolution and low latency. To fully utilize the rich temporal information from events, we design a feature extraction consisting of (1) a regional event feature extractor - taking events as inputs via the proposed event temporal pyramid representation to capture the regional nonlinear motion and (2) a holistic event-frame feature extractor for long-term dependence and continuity motion. We then propose a novel INR-based decoder with spatiotemporal embeddings to capture long-term dependencies with a larger temporal perception field. We validate the effectiveness and generalization of our method on four datasets (both simulated and real data), showing the superiority of our method.

  • 4 authors
·
May 22, 2024

SR-CACO-2: A Dataset for Confocal Fluorescence Microscopy Image Super-Resolution

Confocal fluorescence microscopy is one of the most accessible and widely used imaging techniques for the study of biological processes. Scanning confocal microscopy allows the capture of high-quality images from 3D samples, yet suffers from well-known limitations such as photobleaching and phototoxicity of specimens caused by intense light exposure, which limits its use in some applications, especially for living cells. Cellular damage can be alleviated by changing imaging parameters to reduce light exposure, often at the expense of image quality. Machine/deep learning methods for single-image super-resolution (SISR) can be applied to restore image quality by upscaling lower-resolution (LR) images to produce high-resolution images (HR). These SISR methods have been successfully applied to photo-realistic images due partly to the abundance of publicly available data. In contrast, the lack of publicly available data partly limits their application and success in scanning confocal microscopy. In this paper, we introduce a large scanning confocal microscopy dataset named SR-CACO-2 that is comprised of low- and high-resolution image pairs marked for three different fluorescent markers. It allows the evaluation of performance of SISR methods on three different upscaling levels (X2, X4, X8). SR-CACO-2 contains the human epithelial cell line Caco-2 (ATCC HTB-37), and it is composed of 22 tiles that have been translated in the form of 9,937 image patches for experiments with SISR methods. Given the new SR-CACO-2 dataset, we also provide benchmarking results for 15 state-of-the-art methods that are representative of the main SISR families. Results show that these methods have limited success in producing high-resolution textures, indicating that SR-CACO-2 represents a challenging problem. Our dataset, code and pretrained weights are available: https://github.com/sbelharbi/sr-caco-2.

  • 6 authors
·
Jun 13, 2024

CMTA: Cross-Modal Temporal Alignment for Event-guided Video Deblurring

Video deblurring aims to enhance the quality of restored results in motion-blurred videos by effectively gathering information from adjacent video frames to compensate for the insufficient data in a single blurred frame. However, when faced with consecutively severe motion blur situations, frame-based video deblurring methods often fail to find accurate temporal correspondence among neighboring video frames, leading to diminished performance. To address this limitation, we aim to solve the video deblurring task by leveraging an event camera with micro-second temporal resolution. To fully exploit the dense temporal resolution of the event camera, we propose two modules: 1) Intra-frame feature enhancement operates within the exposure time of a single blurred frame, iteratively enhancing cross-modality features in a recurrent manner to better utilize the rich temporal information of events, 2) Inter-frame temporal feature alignment gathers valuable long-range temporal information to target frames, aggregating sharp features leveraging the advantages of the events. In addition, we present a novel dataset composed of real-world blurred RGB videos, corresponding sharp videos, and event data. This dataset serves as a valuable resource for evaluating event-guided deblurring methods. We demonstrate that our proposed methods outperform state-of-the-art frame-based and event-based motion deblurring methods through extensive experiments conducted on both synthetic and real-world deblurring datasets. The code and dataset are available at https://github.com/intelpro/CMTA.

  • 3 authors
·
Aug 27, 2024

TimeSearch: Hierarchical Video Search with Spotlight and Reflection for Human-like Long Video Understanding

Large video-language models (LVLMs) have shown remarkable performance across various video-language tasks. However, they encounter significant challenges when processing long videos because of the large number of video frames involved. Downsampling long videos in either space or time can lead to visual hallucinations, making it difficult to accurately interpret long videos. Motivated by human hierarchical temporal search strategies, we propose TimeSearch, a novel framework enabling LVLMs to understand long videos in a human-like manner. TimeSearch integrates two human-like primitives into a unified autoregressive LVLM: 1) Spotlight efficiently identifies relevant temporal events through a Temporal-Augmented Frame Representation (TAFR), explicitly binding visual features with timestamps; 2) Reflection evaluates the correctness of the identified events, leveraging the inherent temporal self-reflection capabilities of LVLMs. TimeSearch progressively explores key events and prioritizes temporal search based on reflection confidence. Extensive experiments on challenging long-video benchmarks confirm that TimeSearch substantially surpasses previous state-of-the-art, improving the accuracy from 41.8\% to 51.5\% on the LVBench. Additionally, experiments on temporal grounding demonstrate that appropriate TAFR is adequate to effectively stimulate the surprising temporal grounding ability of LVLMs in a simpler yet versatile manner, which improves mIoU on Charades-STA by 11.8\%. The code will be released.

  • 6 authors
·
Apr 2, 2025

Multi-marginal Schrödinger Bridges with Iterative Reference Refinement

Practitioners frequently aim to infer an unobserved population trajectory using sample snapshots at multiple time points. For instance, in single-cell sequencing, scientists would like to learn how gene expression evolves over time. But sequencing any cell destroys that cell. So we cannot access any cell's full trajectory, but we can access snapshot samples from many cells. Stochastic differential equations are commonly used to analyze systems with full individual-trajectory access; since here we have only sample snapshots, these methods are inapplicable. The deep learning community has recently explored using Schr\"odinger bridges (SBs) and their extensions to estimate these dynamics. However, these methods either (1) interpolate between just two time points or (2) require a single fixed reference dynamic within the SB, which is often just set to be Brownian motion. But learning piecewise from adjacent time points can fail to capture long-term dependencies. And practitioners are typically able to specify a model class for the reference dynamic but not the exact values of the parameters within it. So we propose a new method that (1) learns the unobserved trajectories from sample snapshots across multiple time points and (2) requires specification only of a class of reference dynamics, not a single fixed one. In particular, we suggest an iterative projection method inspired by Schr\"odinger bridges; we alternate between learning a piecewise SB on the unobserved trajectories and using the learned SB to refine our best guess for the dynamics within the reference class. We demonstrate the advantages of our method via a well-known simulated parametric model from ecology, simulated and real data from systems biology, and real motion-capture data.

  • 3 authors
·
Aug 12, 2024

HoloTime: Taming Video Diffusion Models for Panoramic 4D Scene Generation

The rapid advancement of diffusion models holds the promise of revolutionizing the application of VR and AR technologies, which typically require scene-level 4D assets for user experience. Nonetheless, existing diffusion models predominantly concentrate on modeling static 3D scenes or object-level dynamics, constraining their capacity to provide truly immersive experiences. To address this issue, we propose HoloTime, a framework that integrates video diffusion models to generate panoramic videos from a single prompt or reference image, along with a 360-degree 4D scene reconstruction method that seamlessly transforms the generated panoramic video into 4D assets, enabling a fully immersive 4D experience for users. Specifically, to tame video diffusion models for generating high-fidelity panoramic videos, we introduce the 360World dataset, the first comprehensive collection of panoramic videos suitable for downstream 4D scene reconstruction tasks. With this curated dataset, we propose Panoramic Animator, a two-stage image-to-video diffusion model that can convert panoramic images into high-quality panoramic videos. Following this, we present Panoramic Space-Time Reconstruction, which leverages a space-time depth estimation method to transform the generated panoramic videos into 4D point clouds, enabling the optimization of a holistic 4D Gaussian Splatting representation to reconstruct spatially and temporally consistent 4D scenes. To validate the efficacy of our method, we conducted a comparative analysis with existing approaches, revealing its superiority in both panoramic video generation and 4D scene reconstruction. This demonstrates our method's capability to create more engaging and realistic immersive environments, thereby enhancing user experiences in VR and AR applications.

  • 6 authors
·
Apr 30, 2025 1

Exploring Temporally-Aware Features for Point Tracking

Point tracking in videos is a fundamental task with applications in robotics, video editing, and more. While many vision tasks benefit from pre-trained feature backbones to improve generalizability, point tracking has primarily relied on simpler backbones trained from scratch on synthetic data, which may limit robustness in real-world scenarios. Additionally, point tracking requires temporal awareness to ensure coherence across frames, but using temporally-aware features is still underexplored. Most current methods often employ a two-stage process: an initial coarse prediction followed by a refinement stage to inject temporal information and correct errors from the coarse stage. These approach, however, is computationally expensive and potentially redundant if the feature backbone itself captures sufficient temporal information. In this work, we introduce Chrono, a feature backbone specifically designed for point tracking with built-in temporal awareness. Leveraging pre-trained representations from self-supervised learner DINOv2 and enhanced with a temporal adapter, Chrono effectively captures long-term temporal context, enabling precise prediction even without the refinement stage. Experimental results demonstrate that Chrono achieves state-of-the-art performance in a refiner-free setting on the TAP-Vid-DAVIS and TAP-Vid-Kinetics datasets, among common feature backbones used in point tracking as well as DINOv2, with exceptional efficiency. Project page: https://cvlab-kaist.github.io/Chrono/

  • 6 authors
·
Jan 21, 2025

DisTime: Distribution-based Time Representation for Video Large Language Models

Despite advances in general video understanding, Video Large Language Models (Video-LLMs) face challenges in precise temporal localization due to discrete time representations and limited temporally aware datasets. Existing methods for temporal expression either conflate time with text-based numerical values, add a series of dedicated temporal tokens, or regress time using specialized temporal grounding heads. To address these issues, we introduce DisTime, a lightweight framework designed to enhance temporal comprehension in Video-LLMs. DisTime employs a learnable token to create a continuous temporal embedding space and incorporates a Distribution-based Time Decoder that generates temporal probability distributions, effectively mitigating boundary ambiguities and maintaining temporal continuity. Additionally, the Distribution-based Time Encoder re-encodes timestamps to provide time markers for Video-LLMs. To overcome temporal granularity limitations in existing datasets, we propose an automated annotation paradigm that combines the captioning capabilities of Video-LLMs with the localization expertise of dedicated temporal models. This leads to the creation of InternVid-TG, a substantial dataset with 1.25M temporally grounded events across 179k videos, surpassing ActivityNet-Caption by 55 times. Extensive experiments demonstrate that DisTime achieves state-of-the-art performance across benchmarks in three time-sensitive tasks while maintaining competitive performance in Video QA tasks. Code and data are released at https://github.com/josephzpng/DisTime.

  • 7 authors
·
May 30, 2025

Computational Long Exposure Mobile Photography

Long exposure photography produces stunning imagery, representing moving elements in a scene with motion-blur. It is generally employed in two modalities, producing either a foreground or a background blur effect. Foreground blur images are traditionally captured on a tripod-mounted camera and portray blurred moving foreground elements, such as silky water or light trails, over a perfectly sharp background landscape. Background blur images, also called panning photography, are captured while the camera is tracking a moving subject, to produce an image of a sharp subject over a background blurred by relative motion. Both techniques are notoriously challenging and require additional equipment and advanced skills. In this paper, we describe a computational burst photography system that operates in a hand-held smartphone camera app, and achieves these effects fully automatically, at the tap of the shutter button. Our approach first detects and segments the salient subject. We track the scene motion over multiple frames and align the images in order to preserve desired sharpness and to produce aesthetically pleasing motion streaks. We capture an under-exposed burst and select the subset of input frames that will produce blur trails of controlled length, regardless of scene or camera motion velocity. We predict inter-frame motion and synthesize motion-blur to fill the temporal gaps between the input frames. Finally, we composite the blurred image with the sharp regular exposure to protect the sharpness of faces or areas of the scene that are barely moving, and produce a final high resolution and high dynamic range (HDR) photograph. Our system democratizes a capability previously reserved to professionals, and makes this creative style accessible to most casual photographers. More information and supplementary material can be found on our project webpage: https://motion-mode.github.io/

  • 6 authors
·
Aug 2, 2023

ML-SIM: A deep neural network for reconstruction of structured illumination microscopy images

Structured illumination microscopy (SIM) has become an important technique for optical super-resolution imaging because it allows a doubling of image resolution at speeds compatible for live-cell imaging. However, the reconstruction of SIM images is often slow and prone to artefacts. Here we propose a versatile reconstruction method, ML-SIM, which makes use of machine learning. The model is an end-to-end deep residual neural network that is trained on a simulated data set to be free of common SIM artefacts. ML-SIM is thus robust to noise and irregularities in the illumination patterns of the raw SIM input frames. The reconstruction method is widely applicable and does not require the acquisition of experimental training data. Since the training data are generated from simulations of the SIM process on images from generic libraries the method can be efficiently adapted to specific experimental SIM implementations. The reconstruction quality enabled by our method is compared with traditional SIM reconstruction methods, and we demonstrate advantages in terms of noise, reconstruction fidelity and contrast for both simulated and experimental inputs. In addition, reconstruction of one SIM frame typically only takes ~100ms to perform on PCs with modern Nvidia graphics cards, making the technique compatible with real-time imaging. The full implementation and the trained networks are available at http://ML-SIM.com.

  • 4 authors
·
Mar 24, 2020

Imaging and controlling electron motion and chemical structural dynamics of biological system in real time and space

Ultrafast electron microscopy (UEM) has found widespread applications in physics, chemistry, and materials science, enabling real-space imaging of dynamics on ultrafast timescales. Recent advances have pushed the temporal resolution of UEM into the attosecond regime, enabling the attomicroscopy technique to directly visualize electron motion. In this work, we extend the capabilities of this powerful imaging tool to investigate ultrafast electron dynamics in a biological system by imaging and controlling light induced electronic and chemical changes in the conductive network of multicellular cable bacteria. Using electron energy loss spectroscopy (EELS), we first observed a laser induced increase in {\pi}-electron density, accompanied by spectral peak broadening and a blueshift features indicative of enhanced conductivity and structural modification. We also traced the effect of ultrafast laser pumping on bulk plasmon electron oscillations by monitoring changes in the plasmon like resonance peak. Additionally, we visualized laser induced chemical structural changes in cable bacteria in real space. The imaging results revealed carbon enrichment alongside a depletion of nitrogen and oxygen, highlighting the controllability of chemical dynamics. Moreover, time resolved EELS measurements further revealed a picosecond scale decay and recovery of both {\pi}-electron and plasmonic features, attributed to electron phonon coupling. In addition to shedding light on the mechanism of electron motion in cable bacteria, these findings demonstrate ultrafast modulation and switching of conductivity, underscoring their potential as bio-optoelectronic components operating on ultrafast timescales.

  • 7 authors
·
Oct 2, 2025

Understanding of the properties of neural network approaches for transient light curve approximations

Modern-day time-domain photometric surveys collect a lot of observations of various astronomical objects and the coming era of large-scale surveys will provide even more information on their properties. Spectroscopic follow-ups are especially crucial for transients such as supernovae and most of these objects have not been subject to such studies. }{Flux time series are actively used as an affordable alternative for photometric classification and characterization, for instance, peak identifications and luminosity decline estimations. However, the collected time series are multidimensional and irregularly sampled, while also containing outliers and without any well-defined systematic uncertainties. This paper presents a search for the best-performing methods to approximate the observed light curves over time and wavelength for the purpose of generating time series with regular time steps in each passband.}{We examined several light curve approximation methods based on neural networks such as multilayer perceptrons, Bayesian neural networks, and normalizing flows to approximate observations of a single light curve. Test datasets include simulated PLAsTiCC and real Zwicky Transient Facility Bright Transient Survey light curves of transients.}{The tests demonstrate that even just a few observations are enough to fit the networks and improve the quality of approximation, compared to state-of-the-art models. The methods described in this work have a low computational complexity and are significantly faster than Gaussian processes. Additionally, we analyzed the performance of the approximation techniques from the perspective of further peak identification and transients classification. The study results have been released in an open and user-friendly Fulu Python library available on GitHub for the scientific community.

  • 7 authors
·
Sep 15, 2022

Global Spatial-Temporal Information-based Residual ConvLSTM for Video Space-Time Super-Resolution

By converting low-frame-rate, low-resolution videos into high-frame-rate, high-resolution ones, space-time video super-resolution techniques can enhance visual experiences and facilitate more efficient information dissemination. We propose a convolutional neural network (CNN) for space-time video super-resolution, namely GIRNet. To generate highly accurate features and thus improve performance, the proposed network integrates a feature-level temporal interpolation module with deformable convolutions and a global spatial-temporal information-based residual convolutional long short-term memory (convLSTM) module. In the feature-level temporal interpolation module, we leverage deformable convolution, which adapts to deformations and scale variations of objects across different scene locations. This presents a more efficient solution than conventional convolution for extracting features from moving objects. Our network effectively uses forward and backward feature information to determine inter-frame offsets, leading to the direct generation of interpolated frame features. In the global spatial-temporal information-based residual convLSTM module, the first convLSTM is used to derive global spatial-temporal information from the input features, and the second convLSTM uses the previously computed global spatial-temporal information feature as its initial cell state. This second convLSTM adopts residual connections to preserve spatial information, thereby enhancing the output features. Experiments on the Vimeo90K dataset show that the proposed method outperforms state-of-the-art techniques in peak signal-to-noise-ratio (by 1.45 dB, 1.14 dB, and 0.02 dB over STARnet, TMNet, and 3DAttGAN, respectively), structural similarity index(by 0.027, 0.023, and 0.006 over STARnet, TMNet, and 3DAttGAN, respectively), and visually.

  • 6 authors
·
Jul 11, 2024

The Pulse of Motion: Measuring Physical Frame Rate from Visual Dynamics

While recent generative video models have achieved remarkable visual realism and are being explored as world models, true physical simulation requires mastering both space and time. Current models can produce visually smooth kinematics, yet they lack a reliable internal motion pulse to ground these motions in a consistent, real-world time scale. This temporal ambiguity stems from the common practice of indiscriminately training on videos with vastly different real-world speeds, forcing them into standardized frame rates. This leads to what we term chronometric hallucination: generated sequences exhibit ambiguous, unstable, and uncontrollable physical motion speeds. To address this, we propose Visual Chronometer, a predictor that recovers the Physical Frames Per Second (PhyFPS) directly from the visual dynamics of an input video. Trained via controlled temporal resampling, our method estimates the true temporal scale implied by the motion itself, bypassing unreliable metadata. To systematically quantify this issue, we establish two benchmarks, PhyFPS-Bench-Real and PhyFPS-Bench-Gen. Our evaluations reveal a harsh reality: state-of-the-art video generators suffer from severe PhyFPS misalignment and temporal instability. Finally, we demonstrate that applying PhyFPS corrections significantly improves the human-perceived naturalness of AI-generated videos. Our project page is https://xiangbogaobarry.github.io/Visual_Chronometer/.

Splannequin: Freezing Monocular Mannequin-Challenge Footage with Dual-Detection Splatting

Synthesizing high-fidelity frozen 3D scenes from monocular Mannequin-Challenge (MC) videos is a unique problem distinct from standard dynamic scene reconstruction. Instead of focusing on modeling motion, our goal is to create a frozen scene while strategically preserving subtle dynamics to enable user-controlled instant selection. To achieve this, we introduce a novel application of dynamic Gaussian splatting: the scene is modeled dynamically, which retains nearby temporal variation, and a static scene is rendered by fixing the model's time parameter. However, under this usage, monocular capture with sparse temporal supervision introduces artifacts like ghosting and blur for Gaussians that become unobserved or occluded at weakly supervised timestamps. We propose Splannequin, an architecture-agnostic regularization that detects two states of Gaussian primitives, hidden and defective, and applies temporal anchoring. Under predominantly forward camera motion, hidden states are anchored to their recent well-observed past states, while defective states are anchored to future states with stronger supervision. Our method integrates into existing dynamic Gaussian pipelines via simple loss terms, requires no architectural changes, and adds zero inference overhead. This results in markedly improved visual quality, enabling high-fidelity, user-selectable frozen-time renderings, validated by a 96% user preference. Project page: https://chien90190.github.io/splannequin/

  • 5 authors
·
Dec 4, 2025 2

Temporal Enhanced Training of Multi-view 3D Object Detector via Historical Object Prediction

In this paper, we propose a new paradigm, named Historical Object Prediction (HoP) for multi-view 3D detection to leverage temporal information more effectively. The HoP approach is straightforward: given the current timestamp t, we generate a pseudo Bird's-Eye View (BEV) feature of timestamp t-k from its adjacent frames and utilize this feature to predict the object set at timestamp t-k. Our approach is motivated by the observation that enforcing the detector to capture both the spatial location and temporal motion of objects occurring at historical timestamps can lead to more accurate BEV feature learning. First, we elaborately design short-term and long-term temporal decoders, which can generate the pseudo BEV feature for timestamp t-k without the involvement of its corresponding camera images. Second, an additional object decoder is flexibly attached to predict the object targets using the generated pseudo BEV feature. Note that we only perform HoP during training, thus the proposed method does not introduce extra overheads during inference. As a plug-and-play approach, HoP can be easily incorporated into state-of-the-art BEV detection frameworks, including BEVFormer and BEVDet series. Furthermore, the auxiliary HoP approach is complementary to prevalent temporal modeling methods, leading to significant performance gains. Extensive experiments are conducted to evaluate the effectiveness of the proposed HoP on the nuScenes dataset. We choose the representative methods, including BEVFormer and BEVDet4D-Depth to evaluate our method. Surprisingly, HoP achieves 68.5% NDS and 62.4% mAP with ViT-L on nuScenes test, outperforming all the 3D object detectors on the leaderboard. Codes will be available at https://github.com/Sense-X/HoP.

  • 7 authors
·
Apr 3, 2023

SUDS: Scalable Urban Dynamic Scenes

We extend neural radiance fields (NeRFs) to dynamic large-scale urban scenes. Prior work tends to reconstruct single video clips of short durations (up to 10 seconds). Two reasons are that such methods (a) tend to scale linearly with the number of moving objects and input videos because a separate model is built for each and (b) tend to require supervision via 3D bounding boxes and panoptic labels, obtained manually or via category-specific models. As a step towards truly open-world reconstructions of dynamic cities, we introduce two key innovations: (a) we factorize the scene into three separate hash table data structures to efficiently encode static, dynamic, and far-field radiance fields, and (b) we make use of unlabeled target signals consisting of RGB images, sparse LiDAR, off-the-shelf self-supervised 2D descriptors, and most importantly, 2D optical flow. Operationalizing such inputs via photometric, geometric, and feature-metric reconstruction losses enables SUDS to decompose dynamic scenes into the static background, individual objects, and their motions. When combined with our multi-branch table representation, such reconstructions can be scaled to tens of thousands of objects across 1.2 million frames from 1700 videos spanning geospatial footprints of hundreds of kilometers, (to our knowledge) the largest dynamic NeRF built to date. We present qualitative initial results on a variety of tasks enabled by our representations, including novel-view synthesis of dynamic urban scenes, unsupervised 3D instance segmentation, and unsupervised 3D cuboid detection. To compare to prior work, we also evaluate on KITTI and Virtual KITTI 2, surpassing state-of-the-art methods that rely on ground truth 3D bounding box annotations while being 10x quicker to train.

  • 4 authors
·
Mar 25, 2023

Mavors: Multi-granularity Video Representation for Multimodal Large Language Model

Long-context video understanding in multimodal large language models (MLLMs) faces a critical challenge: balancing computational efficiency with the retention of fine-grained spatio-temporal patterns. Existing approaches (e.g., sparse sampling, dense sampling with low resolution, and token compression) suffer from significant information loss in temporal dynamics, spatial details, or subtle interactions, particularly in videos with complex motion or varying resolutions. To address this, we propose Mavors, a novel framework that introduces Multi-granularity video representation for holistic long-video modeling. Specifically, Mavors directly encodes raw video content into latent representations through two core components: 1) an Intra-chunk Vision Encoder (IVE) that preserves high-resolution spatial features via 3D convolutions and Vision Transformers, and 2) an Inter-chunk Feature Aggregator (IFA) that establishes temporal coherence across chunks using transformer-based dependency modeling with chunk-level rotary position encodings. Moreover, the framework unifies image and video understanding by treating images as single-frame videos via sub-image decomposition. Experiments across diverse benchmarks demonstrate Mavors' superiority in maintaining both spatial fidelity and temporal continuity, significantly outperforming existing methods in tasks requiring fine-grained spatio-temporal reasoning.

  • 15 authors
·
Apr 14, 2025 2

Fast Spatial Memory with Elastic Test-Time Training

Large Chunk Test-Time Training (LaCT) has shown strong performance on long-context 3D reconstruction, but its fully plastic inference-time updates remain vulnerable to catastrophic forgetting and overfitting. As a result, LaCT is typically instantiated with a single large chunk spanning the full input sequence, falling short of the broader goal of handling arbitrarily long sequences in a single pass. We propose Elastic Test-Time Training inspired by elastic weight consolidation, that stabilizes LaCT fast-weight updates with a Fisher-weighted elastic prior around a maintained anchor state. The anchor evolves as an exponential moving average of past fast weights to balance stability and plasticity. Based on this updated architecture, we introduce Fast Spatial Memory (FSM), an efficient and scalable model for 4D reconstruction that learns spatiotemporal representations from long observation sequences and renders novel view-time combinations. We pre-trained FSM on large-scale curated 3D/4D data to capture the dynamics and semantics of complex spatial environments. Extensive experiments show that FSM supports fast adaptation over long sequences and delivers high-quality 3D/4D reconstruction with smaller chunks and mitigating the camera-interpolation shortcut. Overall, we hope to advance LaCT beyond the bounded single-chunk setting toward robust multi-chunk adaptation, a necessary step for generalization to genuinely longer sequences, while substantially alleviating the activation-memory bottleneck.

  • 6 authors
·
Apr 7 2

MedVSR: Medical Video Super-Resolution with Cross State-Space Propagation

High-resolution (HR) medical videos are vital for accurate diagnosis, yet are hard to acquire due to hardware limitations and physiological constraints. Clinically, the collected low-resolution (LR) medical videos present unique challenges for video super-resolution (VSR) models, including camera shake, noise, and abrupt frame transitions, which result in significant optical flow errors and alignment difficulties. Additionally, tissues and organs exhibit continuous and nuanced structures, but current VSR models are prone to introducing artifacts and distorted features that can mislead doctors. To this end, we propose MedVSR, a tailored framework for medical VSR. It first employs Cross State-Space Propagation (CSSP) to address the imprecise alignment by projecting distant frames as control matrices within state-space models, enabling the selective propagation of consistent and informative features to neighboring frames for effective alignment. Moreover, we design an Inner State-Space Reconstruction (ISSR) module that enhances tissue structures and reduces artifacts with joint long-range spatial feature learning and large-kernel short-range information aggregation. Experiments across four datasets in diverse medical scenarios, including endoscopy and cataract surgeries, show that MedVSR significantly outperforms existing VSR models in reconstruction performance and efficiency. Code released at https://github.com/CUHK-AIM-Group/MedVSR.

  • 5 authors
·
Sep 25, 2025

Spatio-Temporal Difference Guided Motion Deblurring with the Complementary Vision Sensor

Motion blur arises when rapid scene changes occur during the exposure period, collapsing rich intra-exposure motion into a single RGB frame. Without explicit structural or temporal cues, RGB-only deblurring is highly ill-posed and often fails under extreme motion. Inspired by the human visual system, brain-inspired vision sensors introduce temporally dense information to alleviate this problem. However, event cameras still suffer from event rate saturation under rapid motion, while the event modality entangles edge features and motion cues, which limits their effectiveness. As a recent breakthrough, the complementary vision sensor (CVS), Tianmouc, captures synchronized RGB frames together with high-frame-rate, multi-bit spatial difference (SD, encoding structural edges) and temporal difference (TD, encoding motion cues) data within a single RGB exposure, offering a promising solution for RGB deblurring under extreme dynamic scenes. To fully leverage these complementary modalities, we propose Spatio-Temporal Difference Guided Deblur Net (STGDNet), which adopts a recurrent multi-branch architecture that iteratively encodes and fuses SD and TD sequences to restore structure and color details lost in blurry RGB inputs. Our method outperforms current RGB or event-based approaches in both synthetic CVS dataset and real-world evaluations. Moreover, STGDNet exhibits strong generalization capability across over 100 extreme real-world scenarios. Project page: https://tmcDeblur.github.io/

  • 9 authors
·
Apr 11

Representing Long Volumetric Video with Temporal Gaussian Hierarchy

This paper aims to address the challenge of reconstructing long volumetric videos from multi-view RGB videos. Recent dynamic view synthesis methods leverage powerful 4D representations, like feature grids or point cloud sequences, to achieve high-quality rendering results. However, they are typically limited to short (1~2s) video clips and often suffer from large memory footprints when dealing with longer videos. To solve this issue, we propose a novel 4D representation, named Temporal Gaussian Hierarchy, to compactly model long volumetric videos. Our key observation is that there are generally various degrees of temporal redundancy in dynamic scenes, which consist of areas changing at different speeds. Motivated by this, our approach builds a multi-level hierarchy of 4D Gaussian primitives, where each level separately describes scene regions with different degrees of content change, and adaptively shares Gaussian primitives to represent unchanged scene content over different temporal segments, thus effectively reducing the number of Gaussian primitives. In addition, the tree-like structure of the Gaussian hierarchy allows us to efficiently represent the scene at a particular moment with a subset of Gaussian primitives, leading to nearly constant GPU memory usage during the training or rendering regardless of the video length. Extensive experimental results demonstrate the superiority of our method over alternative methods in terms of training cost, rendering speed, and storage usage. To our knowledge, this work is the first approach capable of efficiently handling minutes of volumetric video data while maintaining state-of-the-art rendering quality. Our project page is available at: https://zju3dv.github.io/longvolcap.

  • 7 authors
·
Dec 12, 2024

TMA: Temporal Motion Aggregation for Event-based Optical Flow

Event cameras have the ability to record continuous and detailed trajectories of objects with high temporal resolution, thereby providing intuitive motion cues for optical flow estimation. Nevertheless, most existing learning-based approaches for event optical flow estimation directly remould the paradigm of conventional images by representing the consecutive event stream as static frames, ignoring the inherent temporal continuity of event data. In this paper, we argue that temporal continuity is a vital element of event-based optical flow and propose a novel Temporal Motion Aggregation (TMA) approach to unlock its potential. Technically, TMA comprises three components: an event splitting strategy to incorporate intermediate motion information underlying the temporal context, a linear lookup strategy to align temporally fine-grained motion features and a novel motion pattern aggregation module to emphasize consistent patterns for motion feature enhancement. By incorporating temporally fine-grained motion information, TMA can derive better flow estimates than existing methods at early stages, which not only enables TMA to obtain more accurate final predictions, but also greatly reduces the demand for a number of refinements. Extensive experiments on DSEC-Flow and MVSEC datasets verify the effectiveness and superiority of our TMA. Remarkably, compared to E-RAFT, TMA achieves a 6\% improvement in accuracy and a 40\% reduction in inference time on DSEC-Flow. Code will be available at https://github.com/ispc-lab/TMA.

  • 7 authors
·
Mar 21, 2023

UniTS: Unified Time Series Generative Model for Remote Sensing

One of the primary objectives of satellite remote sensing is to capture the complex dynamics of the Earth environment, which encompasses tasks such as reconstructing continuous cloud-free time series images, detecting land cover changes, and forecasting future surface evolution. However, existing methods typically require specialized models tailored to different tasks, lacking unified modeling of spatiotemporal features across multiple time series tasks. In this paper, we propose a Unified Time Series Generative Model (UniTS), a general framework applicable to various time series tasks, including time series reconstruction, time series cloud removal, time series semantic change detection, and time series forecasting. Based on the flow matching generative paradigm, UniTS constructs a deterministic evolution path from noise to targets under the guidance of task-specific conditions, achieving unified modeling of spatiotemporal representations for multiple tasks. The UniTS architecture consists of a diffusion transformer with spatio-temporal blocks, where we design an Adaptive Condition Injector (ACor) to enhance the model's conditional perception of multimodal inputs, enabling high-quality controllable generation. Additionally, we design a Spatiotemporal-aware Modulator (STM) to improve the ability of spatio-temporal blocks to capture complex spatiotemporal dependencies. Furthermore, we construct two high-quality multimodal time series datasets, TS-S12 and TS-S12CR, filling the gap of benchmark datasets for time series cloud removal and forecasting tasks. Extensive experiments demonstrate that UniTS exhibits exceptional generative and cognitive capabilities in both low-level and high-level time series tasks. It significantly outperforms existing methods, particularly when facing challenges such as severe cloud contamination, modality absence, and forecasting phenological variations.

  • 11 authors
·
Dec 4, 2025

Deblur4DGS: 4D Gaussian Splatting from Blurry Monocular Video

Recent 4D reconstruction methods have yielded impressive results but rely on sharp videos as supervision. However, motion blur often occurs in videos due to camera shake and object movement, while existing methods render blurry results when using such videos for reconstructing 4D models. Although a few approaches attempted to address the problem, they struggled to produce high-quality results, due to the inaccuracy in estimating continuous dynamic representations within the exposure time. Encouraged by recent works in 3D motion trajectory modeling using 3D Gaussian Splatting (3DGS), we take 3DGS as the scene representation manner, and propose Deblur4DGS to reconstruct a high-quality 4D model from blurry monocular video. Specifically, we transform continuous dynamic representations estimation within an exposure time into the exposure time estimation. Moreover, we introduce the exposure regularization term, multi-frame, and multi-resolution consistency regularization term to avoid trivial solutions. Furthermore, to better represent objects with large motion, we suggest blur-aware variable canonical Gaussians. Beyond novel-view synthesis, Deblur4DGS can be applied to improve blurry video from multiple perspectives, including deblurring, frame interpolation, and video stabilization. Extensive experiments in both synthetic and real-world data on the above four tasks show that Deblur4DGS outperforms state-of-the-art 4D reconstruction methods. The codes are available at https://github.com/ZcsrenlongZ/Deblur4DGS.

  • 5 authors
·
Jan 19

TimeLens: Rethinking Video Temporal Grounding with Multimodal LLMs

This paper does not introduce a novel method but instead establishes a straightforward, incremental, yet essential baseline for video temporal grounding (VTG), a core capability in video understanding. While multimodal large language models (MLLMs) excel at various video understanding tasks, the recipes for optimizing them for VTG remain under-explored. In this paper, we present TimeLens, a systematic investigation into building MLLMs with strong VTG ability, along two primary dimensions: data quality and algorithmic design. We first expose critical quality issues in existing VTG benchmarks and introduce TimeLens-Bench, comprising meticulously re-annotated versions of three popular benchmarks with strict quality criteria. Our analysis reveals dramatic model re-rankings compared to legacy benchmarks, confirming the unreliability of prior evaluation standards. We also address noisy training data through an automated re-annotation pipeline, yielding TimeLens-100K, a large-scale, high-quality training dataset. Building on our data foundation, we conduct in-depth explorations of algorithmic design principles, yielding a series of meaningful insights and effective yet efficient practices. These include interleaved textual encoding for time representation, a thinking-free reinforcement learning with verifiable rewards (RLVR) approach as the training paradigm, and carefully designed recipes for RLVR training. These efforts culminate in TimeLens models, a family of MLLMs with state-of-the-art VTG performance among open-source models and even surpass proprietary models such as GPT-5 and Gemini-2.5-Flash. All codes, data, and models will be released to facilitate future research.

TencentARC ARC Lab, Tencent PCG
·
Dec 16, 2025 2

μ-Bench: A Vision-Language Benchmark for Microscopy Understanding

Recent advances in microscopy have enabled the rapid generation of terabytes of image data in cell biology and biomedical research. Vision-language models (VLMs) offer a promising solution for large-scale biological image analysis, enhancing researchers' efficiency, identifying new image biomarkers, and accelerating hypothesis generation and scientific discovery. However, there is a lack of standardized, diverse, and large-scale vision-language benchmarks to evaluate VLMs' perception and cognition capabilities in biological image understanding. To address this gap, we introduce {\mu}-Bench, an expert-curated benchmark encompassing 22 biomedical tasks across various scientific disciplines (biology, pathology), microscopy modalities (electron, fluorescence, light), scales (subcellular, cellular, tissue), and organisms in both normal and abnormal states. We evaluate state-of-the-art biomedical, pathology, and general VLMs on {\mu}-Bench and find that: i) current models struggle on all categories, even for basic tasks such as distinguishing microscopy modalities; ii) current specialist models fine-tuned on biomedical data often perform worse than generalist models; iii) fine-tuning in specific microscopy domains can cause catastrophic forgetting, eroding prior biomedical knowledge encoded in their base model. iv) weight interpolation between fine-tuned and pre-trained models offers one solution to forgetting and improves general performance across biomedical tasks. We release {\mu}-Bench under a permissive license to accelerate the research and development of microscopy foundation models.

  • 7 authors
·
Jul 1, 2024 1

DDoS-UNet: Incorporating temporal information using Dynamic Dual-channel UNet for enhancing super-resolution of dynamic MRI

Magnetic resonance imaging (MRI) provides high spatial resolution and excellent soft-tissue contrast without using harmful ionising radiation. Dynamic MRI is an essential tool for interventions to visualise movements or changes of the target organ. However, such MRI acquisition with high temporal resolution suffers from limited spatial resolution - also known as the spatio-temporal trade-off of dynamic MRI. Several approaches, including deep learning based super-resolution approaches, have been proposed to mitigate this trade-off. Nevertheless, such an approach typically aims to super-resolve each time-point separately, treating them as individual volumes. This research addresses the problem by creating a deep learning model which attempts to learn both spatial and temporal relationships. A modified 3D UNet model, DDoS-UNet, is proposed - which takes the low-resolution volume of the current time-point along with a prior image volume. Initially, the network is supplied with a static high-resolution planning scan as the prior image along with the low-resolution input to super-resolve the first time-point. Then it continues step-wise by using the super-resolved time-points as the prior image while super-resolving the subsequent time-points. The model performance was tested with 3D dynamic data that was undersampled to different in-plane levels. The proposed network achieved an average SSIM value of 0.951pm0.017 while reconstructing the lowest resolution data (i.e. only 4\% of the k-space acquired) - which could result in a theoretical acceleration factor of 25. The proposed approach can be used to reduce the required scan-time while achieving high spatial resolution.

  • 5 authors
·
Feb 10, 2022

Learning heterogeneous delays in a layer of spiking neurons for fast motion detection

The precise timing of spikes emitted by neurons plays a crucial role in shaping the response of efferent biological neurons. This temporal dimension of neural activity holds significant importance in understanding information processing in neurobiology, especially for the performance of neuromorphic hardware, such as event-based cameras. Nonetheless, many artificial neural models disregard this critical temporal dimension of neural activity. In this study, we present a model designed to efficiently detect temporal spiking motifs using a layer of spiking neurons equipped with heterogeneous synaptic delays. Our model capitalizes on the diverse synaptic delays present on the dendritic tree, enabling specific arrangements of temporally precise synaptic inputs to synchronize upon reaching the basal dendritic tree. We formalize this process as a time-invariant logistic regression, which can be trained using labeled data. To demonstrate its practical efficacy, we apply the model to naturalistic videos transformed into event streams, simulating the output of the biological retina or event-based cameras. To evaluate the robustness of the model in detecting visual motion, we conduct experiments by selectively pruning weights and demonstrate that the model remains efficient even under significantly reduced workloads. In conclusion, by providing a comprehensive, event-driven computational building block, the incorporation of heterogeneous delays has the potential to greatly improve the performance of future spiking neural network algorithms, particularly in the context of neuromorphic chips.

  • 2 authors
·
Jul 26, 2023

Changen2: Multi-Temporal Remote Sensing Generative Change Foundation Model

Our understanding of the temporal dynamics of the Earth's surface has been advanced by deep vision models, which often require lots of labeled multi-temporal images for training. However, collecting, preprocessing, and annotating multi-temporal remote sensing images at scale is non-trivial since it is expensive and knowledge-intensive. In this paper, we present change data generators based on generative models, which are cheap and automatic, alleviating these data problems. Our main idea is to simulate a stochastic change process over time. We describe the stochastic change process as a probabilistic graphical model (GPCM), which factorizes the complex simulation problem into two more tractable sub-problems, i.e., change event simulation and semantic change synthesis. To solve these two problems, we present Changen2, a GPCM with a resolution-scalable diffusion transformer which can generate time series of images and their semantic and change labels from labeled or unlabeled single-temporal images. Changen2 is a generative change foundation model that can be trained at scale via self-supervision, and can produce change supervisory signals from unlabeled single-temporal images. Unlike existing foundation models, Changen2 synthesizes change data to train task-specific foundation models for change detection. The resulting model possesses inherent zero-shot change detection capabilities and excellent transferability. Experiments suggest Changen2 has superior spatiotemporal scalability, e.g., Changen2 model trained on 256^2 pixel single-temporal images can yield time series of any length and resolutions of 1,024^2 pixels. Changen2 pre-trained models exhibit superior zero-shot performance (narrowing the performance gap to 3% on LEVIR-CD and approximately 10% on both S2Looking and SECOND, compared to fully supervised counterparts) and transferability across multiple types of change tasks.

StanfordUniversity Stanford University
·
Jun 25, 2024

Event-based Temporally Dense Optical Flow Estimation with Sequential Neural Networks

Prior works on event-based optical flow estimation have investigated several gradient-based learning methods to train neural networks for predicting optical flow. However, they do not utilize the fast data rate of event data streams and rely on a spatio-temporal representation constructed from a collection of events over a fixed period of time (often between two grayscale frames). As a result, optical flow is only evaluated at a frequency much lower than the rate data is produced by an event-based camera, leading to a temporally sparse optical flow estimation. To predict temporally dense optical flow, we cast the problem as a sequential learning task and propose a training methodology to train sequential networks for continuous prediction on an event stream. We propose two types of networks: one focused on performance and another focused on compute efficiency. We first train long-short term memory networks (LSTMs) on the DSEC dataset and demonstrated 10x temporally dense optical flow estimation over existing flow estimation approaches. The additional benefit of having a memory to draw long temporal correlations back in time results in a 19.7% improvement in flow prediction accuracy of LSTMs over similar networks with no memory elements. We subsequently show that the inherent recurrence of spiking neural networks (SNNs) enables them to learn and estimate temporally dense optical flow with 31.8% lesser parameters than LSTM, but with a slightly increased error. This demonstrates potential for energy-efficient implementation of fast optical flow prediction using SNNs.

  • 3 authors
·
Oct 3, 2022

ViSMaP: Unsupervised Hour-long Video Summarisation by Meta-Prompting

We introduce ViSMap: Unsupervised Video Summarisation by Meta Prompting, a system to summarise hour long videos with no-supervision. Most existing video understanding models work well on short videos of pre-segmented events, yet they struggle to summarise longer videos where relevant events are sparsely distributed and not pre-segmented. Moreover, long-form video understanding often relies on supervised hierarchical training that needs extensive annotations which are costly, slow and prone to inconsistency. With ViSMaP we bridge the gap between short videos (where annotated data is plentiful) and long ones (where it's not). We rely on LLMs to create optimised pseudo-summaries of long videos using segment descriptions from short ones. These pseudo-summaries are used as training data for a model that generates long-form video summaries, bypassing the need for expensive annotations of long videos. Specifically, we adopt a meta-prompting strategy to iteratively generate and refine creating pseudo-summaries of long videos. The strategy leverages short clip descriptions obtained from a supervised short video model to guide the summary. Each iteration uses three LLMs working in sequence: one to generate the pseudo-summary from clip descriptions, another to evaluate it, and a third to optimise the prompt of the generator. This iteration is necessary because the quality of the pseudo-summaries is highly dependent on the generator prompt, and varies widely among videos. We evaluate our summaries extensively on multiple datasets; our results show that ViSMaP achieves performance comparable to fully supervised state-of-the-art models while generalising across domains without sacrificing performance. Code will be released upon publication.

  • 4 authors
·
Apr 22, 2025 2

Time Blindness: Why Video-Language Models Can't See What Humans Can?

Recent advances in vision-language models (VLMs) have made impressive strides in understanding spatio-temporal relationships in videos. However, when spatial information is obscured, these models struggle to capture purely temporal patterns. We introduce SpookyBench, a benchmark where information is encoded solely in temporal sequences of noise-like frames, mirroring natural phenomena from biological signaling to covert communication. Interestingly, while humans can recognize shapes, text, and patterns in these sequences with over 98% accuracy, state-of-the-art VLMs achieve 0% accuracy. This performance gap highlights a critical limitation: an over-reliance on frame-level spatial features and an inability to extract meaning from temporal cues. Furthermore, when trained in data sets with low spatial signal-to-noise ratios (SNR), temporal understanding of models degrades more rapidly than human perception, especially in tasks requiring fine-grained temporal reasoning. Overcoming this limitation will require novel architectures or training paradigms that decouple spatial dependencies from temporal processing. Our systematic analysis shows that this issue persists across model scales and architectures. We release SpookyBench to catalyze research in temporal pattern recognition and bridge the gap between human and machine video understanding. Dataset and code has been made available on our project website: https://timeblindness.github.io/.

  • 4 authors
·
May 30, 2025 3

Multimodal Language Models for Domain-Specific Procedural Video Summarization

Videos serve as a powerful medium to convey ideas, tell stories, and provide detailed instructions, especially through long-format tutorials. Such tutorials are valuable for learning new skills at one's own pace, yet they can be overwhelming due to their length and dense content. Viewers often seek specific information, like precise measurements or step-by-step execution details, making it essential to extract and summarize key segments efficiently. An intelligent, time-sensitive video assistant capable of summarizing and detecting highlights in long videos is highly sought after. Recent advancements in Multimodal Large Language Models offer promising solutions to develop such an assistant. Our research explores the use of multimodal models to enhance video summarization and step-by-step instruction generation within specific domains. These models need to understand temporal events and relationships among actions across video frames. Our approach focuses on fine-tuning TimeChat to improve its performance in specific domains: cooking and medical procedures. By training the model on domain-specific datasets like Tasty for cooking and MedVidQA for medical procedures, we aim to enhance its ability to generate concise, accurate summaries of instructional videos. We curate and restructure these datasets to create high-quality video-centric instruction data. Our findings indicate that when finetuned on domain-specific procedural data, TimeChat can significantly improve the extraction and summarization of key instructional steps in long-format videos. This research demonstrates the potential of specialized multimodal models to assist with practical tasks by providing personalized, step-by-step guidance tailored to the unique aspects of each domain.

  • 1 authors
·
Jul 7, 2024

Context R-CNN: Long Term Temporal Context for Per-Camera Object Detection

In static monitoring cameras, useful contextual information can stretch far beyond the few seconds typical video understanding models might see: subjects may exhibit similar behavior over multiple days, and background objects remain static. Due to power and storage constraints, sampling frequencies are low, often no faster than one frame per second, and sometimes are irregular due to the use of a motion trigger. In order to perform well in this setting, models must be robust to irregular sampling rates. In this paper we propose a method that leverages temporal context from the unlabeled frames of a novel camera to improve performance at that camera. Specifically, we propose an attention-based approach that allows our model, Context R-CNN, to index into a long term memory bank constructed on a per-camera basis and aggregate contextual features from other frames to boost object detection performance on the current frame. We apply Context R-CNN to two settings: (1) species detection using camera traps, and (2) vehicle detection in traffic cameras, showing in both settings that Context R-CNN leads to performance gains over strong baselines. Moreover, we show that increasing the contextual time horizon leads to improved results. When applied to camera trap data from the Snapshot Serengeti dataset, Context R-CNN with context from up to a month of images outperforms a single-frame baseline by 17.9% mAP, and outperforms S3D (a 3d convolution based baseline) by 11.2% mAP.

  • 5 authors
·
Dec 7, 2019

FineBio: A Fine-Grained Video Dataset of Biological Experiments with Hierarchical Annotation

In the development of science, accurate and reproducible documentation of the experimental process is crucial. Automatic recognition of the actions in experiments from videos would help experimenters by complementing the recording of experiments. Towards this goal, we propose FineBio, a new fine-grained video dataset of people performing biological experiments. The dataset consists of multi-view videos of 32 participants performing mock biological experiments with a total duration of 14.5 hours. One experiment forms a hierarchical structure, where a protocol consists of several steps, each further decomposed into a set of atomic operations. The uniqueness of biological experiments is that while they require strict adherence to steps described in each protocol, there is freedom in the order of atomic operations. We provide hierarchical annotation on protocols, steps, atomic operations, object locations, and their manipulation states, providing new challenges for structured activity understanding and hand-object interaction recognition. To find out challenges on activity understanding in biological experiments, we introduce baseline models and results on four different tasks, including (i) step segmentation, (ii) atomic operation detection (iii) object detection, and (iv) manipulated/affected object detection. Dataset and code are available from https://github.com/aistairc/FineBio.

  • 7 authors
·
Jan 31, 2024

EvaGaussians: Event Stream Assisted Gaussian Splatting from Blurry Images

3D Gaussian Splatting (3D-GS) has demonstrated exceptional capabilities in 3D scene reconstruction and novel view synthesis. However, its training heavily depends on high-quality, sharp images and accurate camera poses. Fulfilling these requirements can be challenging in non-ideal real-world scenarios, where motion-blurred images are commonly encountered in high-speed moving cameras or low-light environments that require long exposure times. To address these challenges, we introduce Event Stream Assisted Gaussian Splatting (EvaGaussians), a novel approach that integrates event streams captured by an event camera to assist in reconstructing high-quality 3D-GS from blurry images. Capitalizing on the high temporal resolution and dynamic range offered by the event camera, we leverage the event streams to explicitly model the formation process of motion-blurred images and guide the deblurring reconstruction of 3D-GS. By jointly optimizing the 3D-GS parameters and recovering camera motion trajectories during the exposure time, our method can robustly facilitate the acquisition of high-fidelity novel views with intricate texture details. We comprehensively evaluated our method and compared it with previous state-of-the-art deblurring rendering methods. Both qualitative and quantitative comparisons demonstrate that our method surpasses existing techniques in restoring fine details from blurry images and producing high-fidelity novel views.

  • 6 authors
·
May 29, 2024

Mem4D: Decoupling Static and Dynamic Memory for Dynamic Scene Reconstruction

Reconstructing dense geometry for dynamic scenes from a monocular video is a critical yet challenging task. Recent memory-based methods enable efficient online reconstruction, but they fundamentally suffer from a Memory Demand Dilemma: The memory representation faces an inherent conflict between the long-term stability required for static structures and the rapid, high-fidelity detail retention needed for dynamic motion. This conflict forces existing methods into a compromise, leading to either geometric drift in static structures or blurred, inaccurate reconstructions of dynamic objects. To address this dilemma, we propose Mem4D, a novel framework that decouples the modeling of static geometry and dynamic motion. Guided by this insight, we design a dual-memory architecture: 1) The Transient Dynamics Memory (TDM) focuses on capturing high-frequency motion details from recent frames, enabling accurate and fine-grained modeling of dynamic content; 2) The Persistent Structure Memory (PSM) compresses and preserves long-term spatial information, ensuring global consistency and drift-free reconstruction for static elements. By alternating queries to these specialized memories, Mem4D simultaneously maintains static geometry with global consistency and reconstructs dynamic elements with high fidelity. Experiments on challenging benchmarks demonstrate that our method achieves state-of-the-art or competitive performance while maintaining high efficiency. Codes will be publicly available.

  • 10 authors
·
Aug 11, 2025

Time-Aware One Step Diffusion Network for Real-World Image Super-Resolution

Diffusion-based real-world image super-resolution (Real-ISR) methods have demonstrated impressive performance. To achieve efficient Real-ISR, many works employ Variational Score Distillation (VSD) to distill pre-trained stable-diffusion (SD) model for one-step SR with a fixed timestep. However, due to the different noise injection timesteps, the SD will perform different generative priors. Therefore, a fixed timestep is difficult for these methods to fully leverage the generative priors in SD, leading to suboptimal performance. To address this, we propose a Time-Aware one-step Diffusion Network for Real-ISR (TADSR). We first introduce a Time-Aware VAE Encoder, which projects the same image into different latent features based on timesteps. Through joint dynamic variation of timesteps and latent features, the student model can better align with the input pattern distribution of the pre-trained SD, thereby enabling more effective utilization of SD's generative capabilities. To better activate the generative prior of SD at different timesteps, we propose a Time-Aware VSD loss that bridges the timesteps of the student model and those of the teacher model, thereby producing more consistent generative prior guidance conditioned on timesteps. Additionally, though utilizing the generative prior in SD at different timesteps, our method can naturally achieve controllable trade-offs between fidelity and realism by changing the timestep condition. Experimental results demonstrate that our method achieves both state-of-the-art performance and controllable SR results with only a single step.

  • 7 authors
·
Aug 22, 2025

Pre-training vision models for the classification of alerts from wide-field time-domain surveys

Modern wide-field time-domain surveys facilitate the study of transient, variable and moving phenomena by conducting image differencing and relaying alerts to their communities. Machine learning tools have been used on data from these surveys and their precursors for more than a decade, and convolutional neural networks (CNNs), which make predictions directly from input images, saw particularly broad adoption through the 2010s. Since then, continually rapid advances in computer vision have transformed the standard practices around using such models. It is now commonplace to use standardized architectures pre-trained on large corpora of everyday images (e.g., ImageNet). In contrast, time-domain astronomy studies still typically design custom CNN architectures and train them from scratch. Here, we explore the affects of adopting various pre-training regimens and standardized model architectures on the performance of alert classification. We find that the resulting models match or outperform a custom, specialized CNN like what is typically used for filtering alerts. Moreover, our results show that pre-training on galaxy images from Galaxy Zoo tends to yield better performance than pre-training on ImageNet or training from scratch. We observe that the design of standardized architectures are much better optimized than the custom CNN baseline, requiring significantly less time and memory for inference despite having more trainable parameters. On the eve of the Legacy Survey of Space and Time and other image-differencing surveys, these findings advocate for a paradigm shift in the creation of vision models for alerts, demonstrating that greater performance and efficiency, in time and in data, can be achieved by adopting the latest practices from the computer vision field.

  • 18 authors
·
Dec 12, 2025