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Apr 20

xMEN: A Modular Toolkit for Cross-Lingual Medical Entity Normalization

Objective: To improve performance of medical entity normalization across many languages, especially when fewer language resources are available compared to English. Materials and Methods: We introduce xMEN, a modular system for cross-lingual medical entity normalization, which performs well in both low- and high-resource scenarios. When synonyms in the target language are scarce for a given terminology, we leverage English aliases via cross-lingual candidate generation. For candidate ranking, we incorporate a trainable cross-encoder model if annotations for the target task are available. We also evaluate cross-encoders trained in a weakly supervised manner based on machine-translated datasets from a high resource domain. Our system is publicly available as an extensible Python toolkit. Results: xMEN improves the state-of-the-art performance across a wide range of multilingual benchmark datasets. Weakly supervised cross-encoders are effective when no training data is available for the target task. Through the compatibility of xMEN with the BigBIO framework, it can be easily used with existing and prospective datasets. Discussion: Our experiments show the importance of balancing the output of general-purpose candidate generators with subsequent trainable re-rankers, which we achieve through a rank regularization term in the loss function of the cross-encoder. However, error analysis reveals that multi-word expressions and other complex entities are still challenging. Conclusion: xMEN exhibits strong performance for medical entity normalization in multiple languages, even when no labeled data and few terminology aliases for the target language are available. Its configuration system and evaluation modules enable reproducible benchmarks. Models and code are available online at the following URL: https://github.com/hpi-dhc/xmen

  • 5 authors
·
Oct 17, 2023

MultiTACRED: A Multilingual Version of the TAC Relation Extraction Dataset

Relation extraction (RE) is a fundamental task in information extraction, whose extension to multilingual settings has been hindered by the lack of supervised resources comparable in size to large English datasets such as TACRED (Zhang et al., 2017). To address this gap, we introduce the MultiTACRED dataset, covering 12 typologically diverse languages from 9 language families, which is created by machine-translating TACRED instances and automatically projecting their entity annotations. We analyze translation and annotation projection quality, identify error categories, and experimentally evaluate fine-tuned pretrained mono- and multilingual language models in common transfer learning scenarios. Our analyses show that machine translation is a viable strategy to transfer RE instances, with native speakers judging more than 83% of the translated instances to be linguistically and semantically acceptable. We find monolingual RE model performance to be comparable to the English original for many of the target languages, and that multilingual models trained on a combination of English and target language data can outperform their monolingual counterparts. However, we also observe a variety of translation and annotation projection errors, both due to the MT systems and linguistic features of the target languages, such as pronoun-dropping, compounding and inflection, that degrade dataset quality and RE model performance.

  • 3 authors
·
May 8, 2023

Medical mT5: An Open-Source Multilingual Text-to-Text LLM for The Medical Domain

Research on language technology for the development of medical applications is currently a hot topic in Natural Language Understanding and Generation. Thus, a number of large language models (LLMs) have recently been adapted to the medical domain, so that they can be used as a tool for mediating in human-AI interaction. While these LLMs display competitive performance on automated medical texts benchmarks, they have been pre-trained and evaluated with a focus on a single language (English mostly). This is particularly true of text-to-text models, which typically require large amounts of domain-specific pre-training data, often not easily accessible for many languages. In this paper, we address these shortcomings by compiling, to the best of our knowledge, the largest multilingual corpus for the medical domain in four languages, namely English, French, Italian and Spanish. This new corpus has been used to train Medical mT5, the first open-source text-to-text multilingual model for the medical domain. Additionally, we present two new evaluation benchmarks for all four languages with the aim of facilitating multilingual research in this domain. A comprehensive evaluation shows that Medical mT5 outperforms both encoders and similarly sized text-to-text models for the Spanish, French, and Italian benchmarks, while being competitive with current state-of-the-art LLMs in English.

  • 13 authors
·
Apr 11, 2024

Massively Multilingual Lexical Specialization of Multilingual Transformers

While pretrained language models (PLMs) primarily serve as general-purpose text encoders that can be fine-tuned for a wide variety of downstream tasks, recent work has shown that they can also be rewired to produce high-quality word representations (i.e., static word embeddings) and yield good performance in type-level lexical tasks. While existing work primarily focused on the lexical specialization of monolingual PLMs with immense quantities of monolingual constraints, in this work we expose massively multilingual transformers (MMTs, e.g., mBERT or XLM-R) to multilingual lexical knowledge at scale, leveraging BabelNet as the readily available rich source of multilingual and cross-lingual type-level lexical knowledge. Concretely, we use BabelNet's multilingual synsets to create synonym pairs (or synonym-gloss pairs) across 50 languages and then subject the MMTs (mBERT and XLM-R) to a lexical specialization procedure guided by a contrastive objective. We show that such massively multilingual lexical specialization brings substantial gains in two standard cross-lingual lexical tasks, bilingual lexicon induction and cross-lingual word similarity, as well as in cross-lingual sentence retrieval. Crucially, we observe gains for languages unseen in specialization, indicating that multilingual lexical specialization enables generalization to languages with no lexical constraints. In a series of subsequent controlled experiments, we show that the number of specialization constraints plays a much greater role than the set of languages from which they originate.

  • 3 authors
·
Aug 1, 2022

DICTDIS: Dictionary Constrained Disambiguation for Improved NMT

Domain-specific neural machine translation (NMT) systems (e.g., in educational applications) are socially significant with the potential to help make information accessible to a diverse set of users in multilingual societies. It is desirable that such NMT systems be lexically constrained and draw from domain-specific dictionaries. Dictionaries could present multiple candidate translations for a source word/phrase due to the polysemous nature of words. The onus is then on the NMT model to choose the contextually most appropriate candidate. Prior work has largely ignored this problem and focused on the single candidate constraint setting wherein the target word or phrase is replaced by a single constraint. In this work we present DictDis, a lexically constrained NMT system that disambiguates between multiple candidate translations derived from dictionaries. We achieve this by augmenting training data with multiple dictionary candidates to actively encourage disambiguation during training by implicitly aligning multiple candidate constraints. We demonstrate the utility of DictDis via extensive experiments on English-Hindi and English-German sentences in a variety of domains including regulatory, finance, engineering. We also present comparisons on standard benchmark test datasets. In comparison with existing approaches for lexically constrained and unconstrained NMT, we demonstrate superior performance with respect to constraint copy and disambiguation related measures on all domains while also obtaining improved fluency of up to 2-3 BLEU points on some domains.

  • 3 authors
·
Oct 13, 2022

CLIRudit: Cross-Lingual Information Retrieval of Scientific Documents

Cross-lingual information retrieval (CLIR) consists in finding relevant documents in a language that differs from the language of the queries. This paper presents CLIRudit, a new dataset created to evaluate cross-lingual academic search, focusing on English queries and French documents. The dataset is built using bilingual article metadata from \'Erudit, a Canadian publishing platform, and is designed to represent scenarios in which researchers search for scholarly content in languages other than English. We perform a comprehensive benchmarking of different zero-shot first-stage retrieval methods on the dataset, including dense and sparse retrievers, query and document machine translation, and state-of-the-art multilingual retrievers. Our results show that large dense retrievers, not necessarily trained for the cross-lingual retrieval task, can achieve zero-shot performance comparable to using ground truth human translations, without the need for machine translation. Sparse retrievers, such as BM25 or SPLADE, combined with document translation, show competitive results, providing an efficient alternative to large dense models. This research advances the understanding of cross-lingual academic information retrieval and provides a framework that others can use to build comparable datasets across different languages and disciplines. By making the dataset and code publicly available, we aim to facilitate further research that will help make scientific knowledge more accessible across language barriers.

  • 3 authors
·
Apr 22, 2025

Multilingual Large Language Models: A Systematic Survey

This paper provides a comprehensive survey of the latest research on multilingual large language models (MLLMs). MLLMs not only are able to understand and generate language across linguistic boundaries, but also represent an important advancement in artificial intelligence. We first discuss the architecture and pre-training objectives of MLLMs, highlighting the key components and methodologies that contribute to their multilingual capabilities. We then discuss the construction of multilingual pre-training and alignment datasets, underscoring the importance of data quality and diversity in enhancing MLLM performance. An important focus of this survey is on the evaluation of MLLMs. We present a detailed taxonomy and roadmap covering the assessment of MLLMs' cross-lingual knowledge, reasoning, alignment with human values, safety, interpretability and specialized applications. Specifically, we extensively discuss multilingual evaluation benchmarks and datasets, and explore the use of LLMs themselves as multilingual evaluators. To enhance MLLMs from black to white boxes, we also address the interpretability of multilingual capabilities, cross-lingual transfer and language bias within these models. Finally, we provide a comprehensive review of real-world applications of MLLMs across diverse domains, including biology, medicine, computer science, mathematics and law. We showcase how these models have driven innovation and improvements in these specialized fields while also highlighting the challenges and opportunities in deploying MLLMs within diverse language communities and application scenarios. We listed the paper related in this survey and publicly available at https://github.com/tjunlp-lab/Awesome-Multilingual-LLMs-Papers.

  • 10 authors
·
Nov 17, 2024

HPLT 3.0: Very Large-Scale Multilingual Resources for LLM and MT. Mono- and Bi-lingual Data, Multilingual Evaluation, and Pre-Trained Models

We present an ongoing initiative to provide open, very large, high-quality, and richly annotated textual datasets for almost 200 languages. At 30 trillion tokens, this is likely the largest generally available multilingual collection of LLM pre-training data. These datasets are derived from web crawls from different sources and accompanied with a complete, open-source pipeline for document selection from web archives, text extraction from HTML, language identification for noisy texts, exact and near-deduplication, annotation with, among others, register labels, text quality estimates, and personally identifiable information; and final selection and filtering. We report on data quality probes through contrastive and analytical statistics, through manual inspection of samples for 24 languages, and through end-to-end evaluation of various language model architectures trained on this data. For multilingual LLM evaluation, we provide a comprehensive collection of benchmarks for nine European languages, with special emphasis on natively created tasks, mechanisms to mitigate prompt sensitivity, and refined normalization and aggregation of scores. Additionally, we train and evaluate a family of 57 monolingual encoder-decoder models, as well as a handful of monolingual GPT-like reference models. Besides the monolingual data and models, we also present a very large collection of parallel texts automatically mined from this data, together with a novel parallel corpus synthesized via machine translation.

  • 32 authors
·
Nov 2, 2025

SIB-200: A Simple, Inclusive, and Big Evaluation Dataset for Topic Classification in 200+ Languages and Dialects

Despite the progress we have recorded in the last few years in multilingual natural language processing, evaluation is typically limited to a small set of languages with available datasets which excludes a large number of low-resource languages. In this paper, we created SIB-200 -- a large-scale open-sourced benchmark dataset for topic classification in 200 languages and dialects to address the lack of evaluation dataset for Natural Language Understanding (NLU). For many of the languages covered in SIB-200, this is the first publicly available evaluation dataset for NLU. The dataset is based on Flores-200 machine translation corpus. We annotated the English portion of the dataset and extended the sentence-level annotation to the remaining 203 languages covered in the corpus. Despite the simplicity of this task, our evaluation in full-supervised setting, cross-lingual transfer setting and prompting of large language model setting show that there is still a large gap between the performance of high-resource and low-resource languages when multilingual evaluation is scaled to numerous world languages. We found that languages unseen during the pre-training of multilingual language models, under-represented language families (like Nilotic and Altantic-Congo), and languages from the regions of Africa, Americas, Oceania and South East Asia, often have the lowest performance on our topic classification dataset. We hope our dataset will encourage a more inclusive evaluation of multilingual language models on a more diverse set of languages. https://github.com/dadelani/sib-200

  • 8 authors
·
Sep 14, 2023

Localizing Open-Ontology QA Semantic Parsers in a Day Using Machine Translation

We propose Semantic Parser Localizer (SPL), a toolkit that leverages Neural Machine Translation (NMT) systems to localize a semantic parser for a new language. Our methodology is to (1) generate training data automatically in the target language by augmenting machine-translated datasets with local entities scraped from public websites, (2) add a few-shot boost of human-translated sentences and train a novel XLMR-LSTM semantic parser, and (3) test the model on natural utterances curated using human translators. We assess the effectiveness of our approach by extending the current capabilities of Schema2QA, a system for English Question Answering (QA) on the open web, to 10 new languages for the restaurants and hotels domains. Our models achieve an overall test accuracy ranging between 61% and 69% for the hotels domain and between 64% and 78% for restaurants domain, which compares favorably to 69% and 80% obtained for English parser trained on gold English data and a few examples from validation set. We show our approach outperforms the previous state-of-the-art methodology by more than 30% for hotels and 40% for restaurants with localized ontologies for the subset of languages tested. Our methodology enables any software developer to add a new language capability to a QA system for a new domain, leveraging machine translation, in less than 24 hours.

MDPBench: A Benchmark for Multilingual Document Parsing in Real-World Scenarios

We introduce Multilingual Document Parsing Benchmark, the first benchmark for multilingual digital and photographed document parsing. Document parsing has made remarkable strides, yet almost exclusively on clean, digital, well-formatted pages in a handful of dominant languages. No systematic benchmark exists to evaluate how models perform on digital and photographed documents across diverse scripts and low-resource languages. MDPBench comprises 3,400 document images spanning 17 languages, diverse scripts, and varied photographic conditions, with high-quality annotations produced through a rigorous pipeline of expert model labeling, manual correction, and human verification. To ensure fair comparison and prevent data leakage, we maintain separate public and private evaluation splits. Our comprehensive evaluation of both open-source and closed-source models uncovers a striking finding: while closed-source models (notably Gemini3-Pro) prove relatively robust, open-source alternatives suffer dramatic performance collapse, particularly on non-Latin scripts and real-world photographed documents, with an average drop of 17.8% on photographed documents and 14.0% on non-Latin scripts. These results reveal significant performance imbalances across languages and conditions, and point to concrete directions for building more inclusive, deployment-ready parsing systems. Source available at https://github.com/Yuliang-Liu/MultimodalOCR.

  • 10 authors
·
Mar 30 2

Augmenting Passage Representations with Query Generation for Enhanced Cross-Lingual Dense Retrieval

Effective cross-lingual dense retrieval methods that rely on multilingual pre-trained language models (PLMs) need to be trained to encompass both the relevance matching task and the cross-language alignment task. However, cross-lingual data for training is often scarcely available. In this paper, rather than using more cross-lingual data for training, we propose to use cross-lingual query generation to augment passage representations with queries in languages other than the original passage language. These augmented representations are used at inference time so that the representation can encode more information across the different target languages. Training of a cross-lingual query generator does not require additional training data to that used for the dense retriever. The query generator training is also effective because the pre-training task for the generator (T5 text-to-text training) is very similar to the fine-tuning task (generation of a query). The use of the generator does not increase query latency at inference and can be combined with any cross-lingual dense retrieval method. Results from experiments on a benchmark cross-lingual information retrieval dataset show that our approach can improve the effectiveness of existing cross-lingual dense retrieval methods. Implementation of our methods, along with all generated query files are made publicly available at https://github.com/ielab/xQG4xDR.

  • 3 authors
·
May 6, 2023

Cross-Lingual Transfer for Low-Resource Natural Language Processing

Natural Language Processing (NLP) has seen remarkable advances in recent years, particularly with the emergence of Large Language Models that have achieved unprecedented performance across many tasks. However, these developments have mainly benefited a small number of high-resource languages such as English. The majority of languages still face significant challenges due to the scarcity of training data and computational resources. To address this issue, this thesis focuses on cross-lingual transfer learning, a research area aimed at leveraging data and models from high-resource languages to improve NLP performance for low-resource languages. Specifically, we focus on Sequence Labeling tasks such as Named Entity Recognition, Opinion Target Extraction, and Argument Mining. The research is structured around three main objectives: (1) advancing data-based cross-lingual transfer learning methods through improved translation and annotation projection techniques, (2) developing enhanced model-based transfer learning approaches utilizing state-of-the-art multilingual models, and (3) applying these methods to real-world problems while creating open-source resources that facilitate future research in low-resource NLP. More specifically, this thesis presents a new method to improve data-based transfer with T-Projection, a state-of-the-art annotation projection method that leverages text-to-text multilingual models and machine translation systems. T-Projection significantly outperforms previous annotation projection methods by a wide margin. For model-based transfer, we introduce a constrained decoding algorithm that enhances cross-lingual Sequence Labeling in zero-shot settings using text-to-text models. Finally, we develop Medical mT5, the first multilingual text-to-text medical model, demonstrating the practical impact of our research on real-world applications.

  • 1 authors
·
Feb 4, 2025

Samanantar: The Largest Publicly Available Parallel Corpora Collection for 11 Indic Languages

We present Samanantar, the largest publicly available parallel corpora collection for Indic languages. The collection contains a total of 49.7 million sentence pairs between English and 11 Indic languages (from two language families). Specifically, we compile 12.4 million sentence pairs from existing, publicly-available parallel corpora, and additionally mine 37.4 million sentence pairs from the web, resulting in a 4x increase. We mine the parallel sentences from the web by combining many corpora, tools, and methods: (a) web-crawled monolingual corpora, (b) document OCR for extracting sentences from scanned documents, (c) multilingual representation models for aligning sentences, and (d) approximate nearest neighbor search for searching in a large collection of sentences. Human evaluation of samples from the newly mined corpora validate the high quality of the parallel sentences across 11 languages. Further, we extract 83.4 million sentence pairs between all 55 Indic language pairs from the English-centric parallel corpus using English as the pivot language. We trained multilingual NMT models spanning all these languages on Samanantar, which outperform existing models and baselines on publicly available benchmarks, such as FLORES, establishing the utility of Samanantar. Our data and models are available publicly at https://indicnlp.ai4bharat.org/samanantar/ and we hope they will help advance research in NMT and multilingual NLP for Indic languages.

  • 18 authors
·
Apr 12, 2021

DR.EHR: Dense Retrieval for Electronic Health Record with Knowledge Injection and Synthetic Data

Electronic Health Records (EHRs) are pivotal in clinical practices, yet their retrieval remains a challenge mainly due to semantic gap issues. Recent advancements in dense retrieval offer promising solutions but existing models, both general-domain and biomedical-domain, fall short due to insufficient medical knowledge or mismatched training corpora. This paper introduces DR.EHR, a series of dense retrieval models specifically tailored for EHR retrieval. We propose a two-stage training pipeline utilizing MIMIC-IV discharge summaries to address the need for extensive medical knowledge and large-scale training data. The first stage involves medical entity extraction and knowledge injection from a biomedical knowledge graph, while the second stage employs large language models to generate diverse training data. We train two variants of DR.EHR, with 110M and 7B parameters, respectively. Evaluated on the CliniQ benchmark, our models significantly outperforms all existing dense retrievers, achieving state-of-the-art results. Detailed analyses confirm our models' superiority across various match and query types, particularly in challenging semantic matches like implication and abbreviation. Ablation studies validate the effectiveness of each pipeline component, and supplementary experiments on EHR QA datasets demonstrate the models' generalizability on natural language questions, including complex ones with multiple entities. This work significantly advances EHR retrieval, offering a robust solution for clinical applications.

  • 4 authors
·
Jul 24, 2025

Improving Semantic Proximity in Information Retrieval through Cross-Lingual Alignment

With the increasing accessibility and utilization of multilingual documents, Cross-Lingual Information Retrieval (CLIR) has emerged as an important research area. Conventionally, CLIR tasks have been conducted under settings where the language of documents differs from that of queries, and typically, the documents are composed in a single coherent language. In this paper, we highlight that in such a setting, the cross-lingual alignment capability may not be evaluated adequately. Specifically, we observe that, in a document pool where English documents coexist with another language, most multilingual retrievers tend to prioritize unrelated English documents over the related document written in the same language as the query. To rigorously analyze and quantify this phenomenon, we introduce various scenarios and metrics designed to evaluate the cross-lingual alignment performance of multilingual retrieval models. Furthermore, to improve cross-lingual performance under these challenging conditions, we propose a novel training strategy aimed at enhancing cross-lingual alignment. Using only a small dataset consisting of 2.8k samples, our method significantly improves the cross-lingual retrieval performance while simultaneously mitigating the English inclination problem. Extensive analyses demonstrate that the proposed method substantially enhances the cross-lingual alignment capabilities of most multilingual embedding models.

ClinLinker: Medical Entity Linking of Clinical Concept Mentions in Spanish

Advances in natural language processing techniques, such as named entity recognition and normalization to widely used standardized terminologies like UMLS or SNOMED-CT, along with the digitalization of electronic health records, have significantly advanced clinical text analysis. This study presents ClinLinker, a novel approach employing a two-phase pipeline for medical entity linking that leverages the potential of in-domain adapted language models for biomedical text mining: initial candidate retrieval using a SapBERT-based bi-encoder and subsequent re-ranking with a cross-encoder, trained by following a contrastive-learning strategy to be tailored to medical concepts in Spanish. This methodology, focused initially on content in Spanish, substantially outperforming multilingual language models designed for the same purpose. This is true even for complex scenarios involving heterogeneous medical terminologies and being trained on a subset of the original data. Our results, evaluated using top-k accuracy at 25 and other top-k metrics, demonstrate our approach's performance on two distinct clinical entity linking Gold Standard corpora, DisTEMIST (diseases) and MedProcNER (clinical procedures), outperforming previous benchmarks by 40 points in DisTEMIST and 43 points in MedProcNER, both normalized to SNOMED-CT codes. These findings highlight our approach's ability to address language-specific nuances and set a new benchmark in entity linking, offering a potent tool for enhancing the utility of digital medical records. The resulting system is of practical value, both for large scale automatic generation of structured data derived from clinical records, as well as for exhaustive extraction and harmonization of predefined clinical variables of interest.

  • 5 authors
·
Apr 9, 2024

SCALE: Scaling up the Complexity for Advanced Language Model Evaluation

Recent strides in Large Language Models (LLMs) have saturated many NLP benchmarks (even professional domain-specific ones), emphasizing the need for novel, more challenging novel ones to properly assess LLM capabilities. In this paper, we introduce a novel NLP benchmark that poses challenges to current LLMs across four key dimensions: processing long documents (up to 50K tokens), utilizing domain specific knowledge (embodied in legal texts), multilingual understanding (covering five languages), and multitasking (comprising legal document to document Information Retrieval, Court View Generation, Leading Decision Summarization, Citation Extraction, and eight challenging Text Classification tasks). Our benchmark comprises diverse legal NLP datasets from the Swiss legal system, allowing for a comprehensive study of the underlying Non-English, inherently multilingual, federal legal system. Despite recent advances, efficiently processing long documents for intense review/analysis tasks remains an open challenge for language models. Also, comprehensive, domain-specific benchmarks requiring high expertise to develop are rare, as are multilingual benchmarks. This scarcity underscores our contribution's value, considering most public models are trained predominantly on English corpora, while other languages remain understudied, particularly for practical domain-specific NLP tasks. Our benchmark allows for testing and advancing the state-of-the-art LLMs. As part of our study, we evaluate several pre-trained multilingual language models on our benchmark to establish strong baselines as a point of reference. Despite the large size of our datasets (tens to hundreds of thousands of examples), existing publicly available models struggle with most tasks, even after in-domain pretraining. We publish all resources (benchmark suite, pre-trained models, code) under a fully permissive open CC BY-SA license.

  • 7 authors
·
Jun 15, 2023

BEIR-PL: Zero Shot Information Retrieval Benchmark for the Polish Language

The BEIR dataset is a large, heterogeneous benchmark for Information Retrieval (IR) in zero-shot settings, garnering considerable attention within the research community. However, BEIR and analogous datasets are predominantly restricted to the English language. Our objective is to establish extensive large-scale resources for IR in the Polish language, thereby advancing the research in this NLP area. In this work, inspired by mMARCO and Mr.~TyDi datasets, we translated all accessible open IR datasets into Polish, and we introduced the BEIR-PL benchmark -- a new benchmark which comprises 13 datasets, facilitating further development, training and evaluation of modern Polish language models for IR tasks. We executed an evaluation and comparison of numerous IR models on the newly introduced BEIR-PL benchmark. Furthermore, we publish pre-trained open IR models for Polish language,d marking a pioneering development in this field. Additionally, the evaluation revealed that BM25 achieved significantly lower scores for Polish than for English, which can be attributed to high inflection and intricate morphological structure of the Polish language. Finally, we trained various re-ranking models to enhance the BM25 retrieval, and we compared their performance to identify their unique characteristic features. To ensure accurate model comparisons, it is necessary to scrutinise individual results rather than to average across the entire benchmark. Thus, we thoroughly analysed the outcomes of IR models in relation to each individual data subset encompassed by the BEIR benchmark. The benchmark data is available at URL {\bf https://huggingface.co/clarin-knext}.

  • 5 authors
·
May 31, 2023

Large language models in healthcare and medical domain: A review

The deployment of large language models (LLMs) within the healthcare sector has sparked both enthusiasm and apprehension. These models exhibit the remarkable capability to provide proficient responses to free-text queries, demonstrating a nuanced understanding of professional medical knowledge. This comprehensive survey delves into the functionalities of existing LLMs designed for healthcare applications, elucidating the trajectory of their development, starting from traditional Pretrained Language Models (PLMs) to the present state of LLMs in healthcare sector. First, we explore the potential of LLMs to amplify the efficiency and effectiveness of diverse healthcare applications, particularly focusing on clinical language understanding tasks. These tasks encompass a wide spectrum, ranging from named entity recognition and relation extraction to natural language inference, multi-modal medical applications, document classification, and question-answering. Additionally, we conduct an extensive comparison of the most recent state-of-the-art LLMs in the healthcare domain, while also assessing the utilization of various open-source LLMs and highlighting their significance in healthcare applications. Furthermore, we present the essential performance metrics employed to evaluate LLMs in the biomedical domain, shedding light on their effectiveness and limitations. Finally, we summarize the prominent challenges and constraints faced by large language models in the healthcare sector, offering a holistic perspective on their potential benefits and shortcomings. This review provides a comprehensive exploration of the current landscape of LLMs in healthcare, addressing their role in transforming medical applications and the areas that warrant further research and development.

  • 2 authors
·
Dec 12, 2023