Daily Papers

Continual Test-Time Adaptation (CTTA) generalizes conventional Test-Time Adaptation (TTA) by assuming that the target domain is dynamic over time rather than stationary. In this paper, we explore Multi-Modal Continual Test-Time Adaptation (MM-CTTA) as a new extension of CTTA for 3D semantic segmentation. The key to MM-CTTA is to adaptively attend to the reliable modality while avoiding catastrophic forgetting during continual domain shifts, which is out of the capability of previous TTA or CTTA methods. To fulfill this gap, we propose an MM-CTTA method called Continual Cross-Modal Adaptive Clustering (CoMAC) that addresses this task from two perspectives. On one hand, we propose an adaptive dual-stage mechanism to generate reliable cross-modal predictions by attending to the reliable modality based on the class-wise feature-centroid distance in the latent space. On the other hand, to perform test-time adaptation without catastrophic forgetting, we design class-wise momentum queues that capture confident target features for adaptation while stochastically restoring pseudo-source features to revisit source knowledge. We further introduce two new benchmarks to facilitate the exploration of MM-CTTA in the future. Our experimental results show that our method achieves state-of-the-art performance on both benchmarks.

In this paper, we focus on image inpainting task, aiming at recovering the missing area of an incomplete image given the context information. Recent development in deep generative models enables an efficient end-to-end framework for image synthesis and inpainting tasks, but existing methods based on generative models don't exploit the segmentation information to constrain the object shapes, which usually lead to blurry results on the boundary. To tackle this problem, we propose to introduce the semantic segmentation information, which disentangles the inter-class difference and intra-class variation for image inpainting. This leads to much clearer recovered boundary between semantically different regions and better texture within semantically consistent segments. Our model factorizes the image inpainting process into segmentation prediction (SP-Net) and segmentation guidance (SG-Net) as two steps, which predict the segmentation labels in the missing area first, and then generate segmentation guided inpainting results. Experiments on multiple public datasets show that our approach outperforms existing methods in optimizing the image inpainting quality, and the interactive segmentation guidance provides possibilities for multi-modal predictions of image inpainting.

A multi-modal guardrail must effectively filter image content based on user-defined policies, identifying material that may be hateful, reinforce harmful stereotypes, contain explicit material, or spread misinformation. Deploying such guardrails in real-world applications, however, poses significant challenges. Users often require varied and highly customizable policies and typically cannot provide abundant examples for each custom policy. Consequently, an ideal guardrail should be scalable to the multiple policies and adaptable to evolving user standards with minimal retraining. Existing fine-tuning methods typically condition predictions on pre-defined policies, restricting their generalizability to new policies or necessitating extensive retraining to adapt. Conversely, training-free methods struggle with limited context lengths, making it difficult to incorporate all the policies comprehensively. To overcome these limitations, we propose to condition model's judgment on "precedents", which are the reasoning processes of prior data points similar to the given input. By leveraging precedents instead of fixed policies, our approach greatly enhances the flexibility and adaptability of the guardrail. In this paper, we introduce a critique-revise mechanism for collecting high-quality precedents and two strategies that utilize precedents for robust prediction. Experimental results demonstrate that our approach outperforms previous methods across both few-shot and full-dataset scenarios and exhibits superior generalization to novel policies.

We propose a hierarchical architecture designed for scalable real-time Model Predictive Control (MPC) in complex, multi-modal traffic scenarios. This architecture comprises two key components: 1) RAID-Net, a novel attention-based Recurrent Neural Network that predicts relevant interactions along the MPC prediction horizon between the autonomous vehicle and the surrounding vehicles using Lagrangian duality, and 2) a reduced Stochastic MPC problem that eliminates irrelevant collision avoidance constraints, enhancing computational efficiency. Our approach is demonstrated in a simulated traffic intersection with interactive surrounding vehicles, showcasing a 12x speed-up in solving the motion planning problem. A video demonstrating the proposed architecture in multiple complex traffic scenarios can be found here: https://youtu.be/-pRiOnPb9_c. GitHub: https://github.com/MPC-Berkeley/hmpc_raidnet

Precise crop yield predictions are of national importance for ensuring food security and sustainable agricultural practices. While AI-for-science approaches have exhibited promising achievements in solving many scientific problems such as drug discovery, precipitation nowcasting, etc., the development of deep learning models for predicting crop yields is constantly hindered by the lack of an open and large-scale deep learning-ready dataset with multiple modalities to accommodate sufficient information. To remedy this, we introduce the CropNet dataset, the first terabyte-sized, publicly available, and multi-modal dataset specifically targeting climate change-aware crop yield predictions for the contiguous United States (U.S.) continent at the county level. Our CropNet dataset is composed of three modalities of data, i.e., Sentinel-2 Imagery, WRF-HRRR Computed Dataset, and USDA Crop Dataset, for over 2200 U.S. counties spanning 6 years (2017-2022), expected to facilitate researchers in developing versatile deep learning models for timely and precisely predicting crop yields at the county-level, by accounting for the effects of both short-term growing season weather variations and long-term climate change on crop yields. Besides, we develop the CropNet package, offering three types of APIs, for facilitating researchers in downloading the CropNet data on the fly over the time and region of interest, and flexibly building their deep learning models for accurate crop yield predictions. Extensive experiments have been conducted on our CropNet dataset via employing various types of deep learning solutions, with the results validating the general applicability and the efficacy of the CropNet dataset in climate change-aware crop yield predictions.

Multi-modal co-learning is emerging as an effective paradigm in machine learning, enabling models to collaboratively learn from different modalities to enhance single-modality predictions. Earth Observation (EO) represents a quintessential domain for multi-modal data analysis, wherein diverse remote sensors collect data to sense our planet. This unprecedented volume of data introduces novel challenges. Specifically, the access to the same sensor modalities at both training and inference stages becomes increasingly complex based on real-world constraints affecting remote sensing platforms. In this context, multi-modal co-learning presents a promising strategy to leverage the vast amount of sensor-derived data available at the training stage to improve single-modality models for inference-time deployment. Most current research efforts focus on designing customized solutions for either particular downstream tasks or specific modalities available at the inference stage. To address this, we propose a novel multi-modal co-learning framework capable of generalizing across various tasks without targeting a specific modality for inference. Our approach combines contrastive and modality discriminative learning together to guide single-modality models to structure the internal model manifold into modality-shared and modality-specific information. We evaluate our framework on four EO benchmarks spanning classification and regression tasks across different sensor modalities, where only one of the modalities available during training is accessible at inference time. Our results demonstrate consistent predictive improvements over state-of-the-art approaches from the recent machine learning and computer vision literature, as well as EO-specific methods. The obtained findings validate our framework in the single-modality inference scenarios across a diverse range of EO applications.

Large vision-language models have recently achieved remarkable progress, exhibiting great perception and reasoning abilities concerning visual information. However, how to effectively evaluate these large vision-language models remains a major obstacle, hindering future model development. Traditional benchmarks like VQAv2 or COCO Caption provide quantitative performance measurements but suffer from a lack of fine-grained ability assessment and non-robust evaluation metrics. Recent subjective benchmarks, such as OwlEval, offer comprehensive evaluations of a model's abilities by incorporating human labor, but they are not scalable and display significant bias. In response to these challenges, we propose MMBench, a novel multi-modality benchmark. MMBench methodically develops a comprehensive evaluation pipeline, primarily comprised of two elements. The first element is a meticulously curated dataset that surpasses existing similar benchmarks in terms of the number and variety of evaluation questions and abilities. The second element introduces a novel CircularEval strategy and incorporates the use of ChatGPT. This implementation is designed to convert free-form predictions into pre-defined choices, thereby facilitating a more robust evaluation of the model's predictions. MMBench is a systematically-designed objective benchmark for robustly evaluating the various abilities of vision-language models. We hope MMBench will assist the research community in better evaluating their models and encourage future advancements in this domain. Project page: https://opencompass.org.cn/mmbench.

In semantic segmentation, generalizing a visual system to both seen categories and novel categories at inference time has always been practically valuable yet challenging. To enable such functionality, existing methods mainly rely on either providing several support demonstrations from the visual aspect or characterizing the informative clues from the textual aspect (e.g., the class names). Nevertheless, both two lines neglect the complementary intrinsic of low-level visual and high-level language information, while the explorations that consider visual and textual modalities as a whole to promote predictions are still limited. To close this gap, we propose to encompass textual and visual clues as multi-modal prototypes to allow more comprehensive support for open-world semantic segmentation, and build a novel prototype-based segmentation framework to realize this promise. To be specific, unlike the straightforward combination of bi-modal clues, we decompose the high-level language information as multi-aspect prototypes and aggregate the low-level visual information as more semantic prototypes, on basis of which, a fine-grained complementary fusion makes the multi-modal prototypes more powerful and accurate to promote the prediction. Based on an elastic mask prediction module that permits any number and form of prototype inputs, we are able to solve the zero-shot, few-shot and generalized counterpart tasks in one architecture. Extensive experiments on both PASCAL-5^i and COCO-20^i datasets show the consistent superiority of the proposed method compared with the previous state-of-the-art approaches, and a range of ablation studies thoroughly dissects each component in our framework both quantitatively and qualitatively that verify their effectiveness.

Accurately predicting protein melting temperature changes (Delta Tm) is fundamental for assessing protein stability and guiding protein engineering. Leveraging multi-modal protein representations has shown great promise in capturing the complex relationships among protein sequences, structures, and functions. In this study, we develop models based on powerful protein language models, including ESM-2, ESM-3 and AlphaFold, using various feature extraction methods to enhance prediction accuracy. By utilizing the ESM-3 model, we achieve a new state-of-the-art performance on the s571 test dataset, obtaining a Pearson correlation coefficient (PCC) of 0.50. Furthermore, we conduct a fair evaluation to compare the performance of different protein language models in the Delta Tm prediction task. Our results demonstrate that integrating multi-modal protein representations could advance the prediction of protein melting temperatures.

Efficient and accurate motion prediction is crucial for ensuring safety and informed decision-making in autonomous driving, particularly under dynamic real-world conditions that necessitate multi-modal forecasts. We introduce TrajFlow, a novel flow matching-based motion prediction framework that addresses the scalability and efficiency challenges of existing generative trajectory prediction methods. Unlike conventional generative approaches that employ i.i.d. sampling and require multiple inference passes to capture diverse outcomes, TrajFlow predicts multiple plausible future trajectories in a single pass, significantly reducing computational overhead while maintaining coherence across predictions. Moreover, we propose a ranking loss based on the Plackett-Luce distribution to improve uncertainty estimation of predicted trajectories. Additionally, we design a self-conditioning training technique that reuses the model's own predictions to construct noisy inputs during a second forward pass, thereby improving generalization and accelerating inference. Extensive experiments on the large-scale Waymo Open Motion Dataset (WOMD) demonstrate that TrajFlow achieves state-of-the-art performance across various key metrics, underscoring its effectiveness for safety-critical autonomous driving applications. The code and other details are available on the project website https://traj-flow.github.io/.

Accurate medical classification requires a large number of multi-modal data, and in many cases, different feature types. Previous studies have shown promising results when using multi-modal data, outperforming single-modality models when classifying diseases such as Alzheimer's Disease (AD). However, those models are usually not flexible enough to handle missing modalities. Currently, the most common workaround is discarding samples with missing modalities which leads to considerable data under-utilization. Adding to the fact that labeled medical images are already scarce, the performance of data-driven methods like deep learning can be severely hampered. Therefore, a multi-modal method that can handle missing data in various clinical settings is highly desirable. In this paper, we present Multi-Modal Mixing Transformer (3MAT), a disease classification transformer that not only leverages multi-modal data but also handles missing data scenarios. In this work, we test 3MT for AD and Cognitively normal (CN) classification and mild cognitive impairment (MCI) conversion prediction to progressive MCI (pMCI) or stable MCI (sMCI) using clinical and neuroimaging data. The model uses a novel Cascaded Modality Transformer architecture with cross-attention to incorporate multi-modal information for more informed predictions. We propose a novel modality dropout mechanism to ensure an unprecedented level of modality independence and robustness to handle missing data scenarios. The result is a versatile network that enables the mixing of arbitrary numbers of modalities with different feature types and also ensures full data utilization missing data scenarios. The model is trained and evaluated on the ADNI dataset with the SOTRA performance and further evaluated with the AIBL dataset with missing data.

Molecular structure elucidation from spectroscopic data is a long-standing challenge in Chemistry, traditionally requiring expert interpretation. We introduce NMIRacle, a two-stage generative framework that builds upon recent paradigms in AI-driven spectroscopy with minimal assumptions. In the first stage, NMIRacle learns to reconstruct molecular structures from count-aware fragment encodings, which capture both fragment identities and their occurrences. In the second stage, a spectral encoder maps input spectroscopic measurements (IR, 1H-NMR, 13C-NMR) into a latent embedding that conditions the pre-trained generator. This formulation bridges fragment-level chemical modeling with spectral evidence, yielding accurate molecular predictions. Empirical results show that NMIRacle outperforms existing baselines on molecular elucidation, while maintaining robust performance across increasing levels of molecular complexity.

AI systems are notorious for their fragility; minor input changes can potentially cause major output swings. When such systems are deployed in critical areas like finance, the consequences of their uncertain behavior could be severe. In this paper, we focus on multi-modal time-series forecasting, where imprecision due to noisy or incorrect data can lead to erroneous predictions, impacting stakeholders such as analysts, investors, and traders. Recently, it has been shown that beyond numeric data, graphical transformations can be used with advanced visual models to achieve better performance. In this context, we introduce a rating methodology to assess the robustness of Multi-Modal Time-Series Forecasting Models (MM-TSFM) through causal analysis, which helps us understand and quantify the isolated impact of various attributes on the forecasting accuracy of MM-TSFM. We apply our novel rating method on a variety of numeric and multi-modal forecasting models in a large experimental setup (six input settings of control and perturbations, ten data distributions, time series from six leading stocks in three industries over a year of data, and five time-series forecasters) to draw insights on robust forecasting models and the context of their strengths. Within the scope of our study, our main result is that multi-modal (numeric + visual) forecasting, which was found to be more accurate than numeric forecasting in previous studies, can also be more robust in diverse settings. Our work will help different stakeholders of time-series forecasting understand the models` behaviors along trust (robustness) and accuracy dimensions to select an appropriate model for forecasting using our rating method, leading to improved decision-making.

Drug discovery typically consists of multiple steps, including identifying a target protein key to a disease's etiology, validating that interacting with this target could prevent symptoms or cure the disease, discovering a small molecule or biologic therapeutic to interact with it, and optimizing the candidate molecule through a complex landscape of required properties. Drug discovery related tasks often involve prediction and generation while considering multiple entities that potentially interact, which poses a challenge for typical AI models. For this purpose we present MAMMAL - Molecular Aligned Multi-Modal Architecture and Language - a method that we applied to create a versatile multi-task foundation model ibm/biomed.omics.bl.sm.ma-ted-458m that learns from large-scale biological datasets (2 billion samples) across diverse modalities, including proteins, small molecules, and genes. We introduce a prompt syntax that supports a wide range of classification, regression, and generation tasks. It allows combining different modalities and entity types as inputs and/or outputs. Our model handles combinations of tokens and scalars and enables the generation of small molecules and proteins, property prediction, and transcriptomic lab test predictions. We evaluated the model on 11 diverse downstream tasks spanning different steps within a typical drug discovery pipeline, where it reaches new SOTA in 9 tasks and is comparable to SOTA in 2 tasks. This performance is achieved while using a unified architecture serving all tasks, in contrast to the original SOTA performance achieved using tailored architectures. The model code and pretrained weights are publicly available at https://github.com/BiomedSciAI/biomed-multi-alignment and https://huggingface.co/ibm/biomed.omics.bl.sm.ma-ted-458m.

Establishing the relationship between 3D structures and the energy states of molecular systems has proven to be a promising approach for learning 3D molecular representations. However, existing methods are limited to modeling the molecular energy states from classical mechanics. This limitation results in a significant oversight of quantum mechanical effects, such as quantized (discrete) energy level structures, which offer a more accurate estimation of molecular energy and can be experimentally measured through energy spectra. In this paper, we propose to utilize the energy spectra to enhance the pre-training of 3D molecular representations (MolSpectra), thereby infusing the knowledge of quantum mechanics into the molecular representations. Specifically, we propose SpecFormer, a multi-spectrum encoder for encoding molecular spectra via masked patch reconstruction. By further aligning outputs from the 3D encoder and spectrum encoder using a contrastive objective, we enhance the 3D encoder's understanding of molecules. Evaluations on public benchmarks reveal that our pre-trained representations surpass existing methods in predicting molecular properties and modeling dynamics.

Large Multi-modal Models (LMMs) have recently demonstrated remarkable abilities in visual context understanding and coherent response generation. However, alongside these advancements, the issue of hallucinations has emerged as a significant challenge, producing erroneous responses that are unrelated to the visual contents. In this paper, we introduce a novel contrastive-based decoding method, COuntering DEscription Contrastive Decoding (CODE), which leverages self-generated descriptions as contrasting references during the decoding phase of LMMs to address hallucination issues. CODE utilizes the comprehensive descriptions from model itself as visual counterpart to correct and improve response alignment with actual visual content. By dynamically adjusting the information flow and distribution of next-token predictions in the LMM's vocabulary, CODE enhances the coherence and informativeness of generated responses. Extensive experiments demonstrate that our method significantly reduces hallucinations and improves cross-modal consistency across various benchmarks and cutting-edge LMMs. Our method provides a simple yet effective decoding strategy that can be integrated to existing LMM frameworks without additional training.

Capturing high-dimensional social interactions and feasible futures is essential for predicting trajectories. To address this complex nature, several attempts have been devoted to reducing the dimensionality of the output variables via parametric curve fitting such as the B\'ezier curve and B-spline function. However, these functions, which originate in computer graphics fields, are not suitable to account for socially acceptable human dynamics. In this paper, we present EigenTrajectory (ET), a trajectory prediction approach that uses a novel trajectory descriptor to form a compact space, known here as ET space, in place of Euclidean space, for representing pedestrian movements. We first reduce the complexity of the trajectory descriptor via a low-rank approximation. We transform the pedestrians' history paths into our ET space represented by spatio-temporal principle components, and feed them into off-the-shelf trajectory forecasting models. The inputs and outputs of the models as well as social interactions are all gathered and aggregated in the corresponding ET space. Lastly, we propose a trajectory anchor-based refinement method to cover all possible futures in the proposed ET space. Extensive experiments demonstrate that our EigenTrajectory predictor can significantly improve both the prediction accuracy and reliability of existing trajectory forecasting models on public benchmarks, indicating that the proposed descriptor is suited to represent pedestrian behaviors. Code is publicly available at https://github.com/inhwanbae/EigenTrajectory .

Different from a unimodal model whose input is from a single modality, the input (called multi-modal input) of a multi-modal model is from multiple modalities such as image, 3D points, audio, text, etc. Similar to unimodal models, many existing studies show that a multi-modal model is also vulnerable to adversarial perturbation, where an attacker could add small perturbation to all modalities of a multi-modal input such that the multi-modal model makes incorrect predictions for it. Existing certified defenses are mostly designed for unimodal models, which achieve sub-optimal certified robustness guarantees when extended to multi-modal models as shown in our experimental results. In our work, we propose MMCert, the first certified defense against adversarial attacks to a multi-modal model. We derive a lower bound on the performance of our MMCert under arbitrary adversarial attacks with bounded perturbations to both modalities (e.g., in the context of auto-driving, we bound the number of changed pixels in both RGB image and depth image). We evaluate our MMCert using two benchmark datasets: one for the multi-modal road segmentation task and the other for the multi-modal emotion recognition task. Moreover, we compare our MMCert with a state-of-the-art certified defense extended from unimodal models. Our experimental results show that our MMCert outperforms the baseline.

This paper proposes a unified diffusion framework (dubbed UniDiffuser) to fit all distributions relevant to a set of multi-modal data in one model. Our key insight is -- learning diffusion models for marginal, conditional, and joint distributions can be unified as predicting the noise in the perturbed data, where the perturbation levels (i.e. timesteps) can be different for different modalities. Inspired by the unified view, UniDiffuser learns all distributions simultaneously with a minimal modification to the original diffusion model -- perturbs data in all modalities instead of a single modality, inputs individual timesteps in different modalities, and predicts the noise of all modalities instead of a single modality. UniDiffuser is parameterized by a transformer for diffusion models to handle input types of different modalities. Implemented on large-scale paired image-text data, UniDiffuser is able to perform image, text, text-to-image, image-to-text, and image-text pair generation by setting proper timesteps without additional overhead. In particular, UniDiffuser is able to produce perceptually realistic samples in all tasks and its quantitative results (e.g., the FID and CLIP score) are not only superior to existing general-purpose models but also comparable to the bespoken models (e.g., Stable Diffusion and DALL-E 2) in representative tasks (e.g., text-to-image generation).

Multimodal large language models (MLLMs) have advanced rapidly in recent years. However, existing approaches for vision tasks often rely on indirect representations, such as generating coordinates as text for detection, which limits performance and prevents dense prediction tasks like segmentation. To overcome these challenges, we introduce Patch-as-Decodable Token (PaDT), a unified paradigm that enables MLLMs to directly generate both textual and diverse visual outputs. Central to PaDT are Visual Reference Tokens (VRTs), derived from visual patch embeddings of query images and interleaved seamlessly with LLM's output textual tokens. A lightweight decoder then transforms LLM's outputs into detection, segmentation, and grounding predictions. Unlike prior methods, PaDT processes VRTs independently at each forward pass and dynamically expands the embedding table, thus improving localization and differentiation among similar objects. We further tailor a training strategy for PaDT by randomly selecting VRTs for supervised fine-tuning and introducing a robust per-token cross-entropy loss. Our empirical studies across four visual perception and understanding tasks suggest PaDT consistently achieving state-of-the-art performance, even compared with significantly larger MLLM models. The code is available at https://github.com/Gorilla-Lab-SCUT/PaDT.

Vision foundation models like DINOv2 demonstrate remarkable potential in medical imaging despite their origin in natural image domains. However, their design inherently works best for uni-modal image analysis, limiting their effectiveness for multi-modal imaging tasks that are common in many medical fields, such as neurology and oncology. While supervised models perform well in this setting, they fail to leverage unlabeled datasets and struggle with missing modalities, a frequent challenge in clinical settings. To bridge these gaps, we introduce MM-DINOv2, a novel and efficient framework that adapts the pre-trained vision foundation model DINOv2 for multi-modal medical imaging. Our approach incorporates multi-modal patch embeddings, enabling vision foundation models to effectively process multi-modal imaging data. To address missing modalities, we employ full-modality masking, which encourages the model to learn robust cross-modality relationships. Furthermore, we leverage semi-supervised learning to harness large unlabeled datasets, enhancing both the accuracy and reliability of medical predictions. Applied to glioma subtype classification from multi-sequence brain MRI, our method achieves a Matthews Correlation Coefficient (MCC) of 0.6 on an external test set, surpassing state-of-the-art supervised approaches by +11.1%. Our work establishes a scalable and robust solution for multi-modal medical imaging tasks, leveraging powerful vision foundation models pre-trained on natural images while addressing real-world clinical challenges such as missing data and limited annotations.

Supervised multi-modal learning involves mapping multiple modalities to a target label. Previous studies in this field have concentrated on capturing in isolation either the inter-modality dependencies (the relationships between different modalities and the label) or the intra-modality dependencies (the relationships within a single modality and the label). We argue that these conventional approaches that rely solely on either inter- or intra-modality dependencies may not be optimal in general. We view the multi-modal learning problem from the lens of generative models where we consider the target as a source of multiple modalities and the interaction between them. Towards that end, we propose inter- & intra-modality modeling (I2M2) framework, which captures and integrates both the inter- and intra-modality dependencies, leading to more accurate predictions. We evaluate our approach using real-world healthcare and vision-and-language datasets with state-of-the-art models, demonstrating superior performance over traditional methods focusing only on one type of modality dependency.

Modern astronomical surveys, such as the Euclid mission, produce high-dimensional, multi-modal data sets that include imaging and spectroscopic information for millions of galaxies. These data serve as an ideal benchmark for large, pre-trained multi-modal models, which can leverage vast amounts of unlabelled data. In this work, we present the first exploration of Euclid data with AstroPT, an autoregressive multi-modal foundation model trained on approximately 300 000 optical and infrared Euclid images and spectral energy distributions (SEDs) from the first Euclid Quick Data Release. We compare self-supervised pre-training with baseline fully supervised training across several tasks: galaxy morphology classification; redshift estimation; similarity searches; and outlier detection. Our results show that: (a) AstroPT embeddings are highly informative, correlating with morphology and effectively isolating outliers; (b) including infrared data helps to isolate stars, but degrades the identification of edge-on galaxies, which are better captured by optical images; (c) simple fine-tuning of these embeddings for photometric redshift and stellar mass estimation outperforms a fully supervised approach, even when using only 1% of the training labels; and (d) incorporating SED data into AstroPT via a straightforward multi-modal token-chaining method improves photo-z predictions, and allow us to identify potentially more interesting anomalies (such as ringed or interacting galaxies) compared to a model pre-trained solely on imaging data.

Existing top-performance autonomous driving systems typically rely on the multi-modal fusion strategy for reliable scene understanding. This design is however fundamentally restricted due to overlooking the modality-specific strengths and finally hampering the model performance. To address this limitation, in this work, we introduce a novel modality interaction strategy that allows individual per-modality representations to be learned and maintained throughout, enabling their unique characteristics to be exploited during the whole perception pipeline. To demonstrate the effectiveness of the proposed strategy, we design DeepInteraction++, a multi-modal interaction framework characterized by a multi-modal representational interaction encoder and a multi-modal predictive interaction decoder. Specifically, the encoder is implemented as a dual-stream Transformer with specialized attention operation for information exchange and integration between separate modality-specific representations. Our multi-modal representational learning incorporates both object-centric, precise sampling-based feature alignment and global dense information spreading, essential for the more challenging planning task. The decoder is designed to iteratively refine the predictions by alternately aggregating information from separate representations in a unified modality-agnostic manner, realizing multi-modal predictive interaction. Extensive experiments demonstrate the superior performance of the proposed framework on both 3D object detection and end-to-end autonomous driving tasks. Our code is available at https://github.com/fudan-zvg/DeepInteraction.

Human pose forecasting garners attention for its diverse applications. However, challenges in modeling the multi-modal nature of human motion and intricate interactions among agents persist, particularly with longer timescales and more agents. In this paper, we propose an interaction-aware trajectory-conditioned long-term multi-agent human pose forecasting model, utilizing a coarse-to-fine prediction approach: multi-modal global trajectories are initially forecasted, followed by respective local pose forecasts conditioned on each mode. In doing so, our Trajectory2Pose model introduces a graph-based agent-wise interaction module for a reciprocal forecast of local motion-conditioned global trajectory and trajectory-conditioned local pose. Our model effectively handles the multi-modality of human motion and the complexity of long-term multi-agent interactions, improving performance in complex environments. Furthermore, we address the lack of long-term (6s+) multi-agent (5+) datasets by constructing a new dataset from real-world images and 2D annotations, enabling a comprehensive evaluation of our proposed model. State-of-the-art prediction performance on both complex and simpler datasets confirms the generalized effectiveness of our method. The code is available at https://github.com/Jaewoo97/T2P.

The integration of multi-omics single-cell data remains challenging due to high-dimensionality and complex inter-modality relationships. To address this, we introduce MoRE-GNN (Multi-omics Relational Edge Graph Neural Network), a heterogeneous graph autoencoder that combines graph convolution and attention mechanisms to dynamically construct relational graphs directly from data. Evaluations on six publicly available datasets demonstrate that MoRE-GNN captures biologically meaningful relationships and outperforms existing methods, particularly in settings with strong inter-modality correlations. Furthermore, the learned representations allow for accurate downstream cross-modal predictions. While performance may vary with dataset complexity, MoRE-GNN offers an adaptive, scalable and interpretable framework for advancing multi-omics integration.

This work investigates a simple yet powerful dense prediction task adapter for Vision Transformer (ViT). Unlike recently advanced variants that incorporate vision-specific inductive biases into their architectures, the plain ViT suffers inferior performance on dense predictions due to weak prior assumptions. To address this issue, we propose the ViT-Adapter, which allows plain ViT to achieve comparable performance to vision-specific transformers. Specifically, the backbone in our framework is a plain ViT that can learn powerful representations from large-scale multi-modal data. When transferring to downstream tasks, a pre-training-free adapter is used to introduce the image-related inductive biases into the model, making it suitable for these tasks. We verify ViT-Adapter on multiple dense prediction tasks, including object detection, instance segmentation, and semantic segmentation. Notably, without using extra detection data, our ViT-Adapter-L yields state-of-the-art 60.9 box AP and 53.0 mask AP on COCO test-dev. We hope that the ViT-Adapter could serve as an alternative for vision-specific transformers and facilitate future research. The code and models will be released at https://github.com/czczup/ViT-Adapter.

Worldwide geolocalization aims to locate the precise location at the coordinate level of photos taken anywhere on the Earth. It is very challenging due to 1) the difficulty of capturing subtle location-aware visual semantics, and 2) the heterogeneous geographical distribution of image data. As a result, existing studies have clear limitations when scaled to a worldwide context. They may easily confuse distant images with similar visual contents, or cannot adapt to various locations worldwide with different amounts of relevant data. To resolve these limitations, we propose G3, a novel framework based on Retrieval-Augmented Generation (RAG). In particular, G3 consists of three steps, i.e., Geo-alignment, Geo-diversification, and Geo-verification to optimize both retrieval and generation phases of worldwide geolocalization. During Geo-alignment, our solution jointly learns expressive multi-modal representations for images, GPS and textual descriptions, which allows us to capture location-aware semantics for retrieving nearby images for a given query. During Geo-diversification, we leverage a prompt ensembling method that is robust to inconsistent retrieval performance for different image queries. Finally, we combine both retrieved and generated GPS candidates in Geo-verification for location prediction. Experiments on two well-established datasets IM2GPS3k and YFCC4k verify the superiority of G3 compared to other state-of-the-art methods.

We show that chimpanzee behaviour understanding from camera traps can be enhanced by providing visual architectures with access to an embedding of text descriptions that detail species behaviours. In particular, we present a vision-language model which employs multi-modal decoding of visual features extracted directly from camera trap videos to process query tokens representing behaviours and output class predictions. Query tokens are initialised using a standardised ethogram of chimpanzee behaviour, rather than using random or name-based initialisations. In addition, the effect of initialising query tokens using a masked language model fine-tuned on a text corpus of known behavioural patterns is explored. We evaluate our system on the PanAf500 and PanAf20K datasets and demonstrate the performance benefits of our multi-modal decoding approach and query initialisation strategy on multi-class and multi-label recognition tasks, respectively. Results and ablations corroborate performance improvements. We achieve state-of-the-art performance over vision and vision-language models in top-1 accuracy (+6.34%) on PanAf500 and overall (+1.1%) and tail-class (+2.26%) mean average precision on PanAf20K. We share complete source code and network weights for full reproducibility of results and easy utilisation.

Time series forecasting is central to decision-making in domains as diverse as energy, finance, climate, and public health. In practice, forecasters face thousands of short, noisy series that vary in frequency, quality, and horizon, where the dominant cost lies not in model fitting, but in the labor-intensive preprocessing, validation, and ensembling required to obtain reliable predictions. Prevailing statistical and deep learning models are tailored to specific datasets or domains and generalize poorly. A general, domain-agnostic framework that minimizes human intervention is urgently in demand. In this paper, we introduce TimeSeriesScientist (TSci), the first LLM-driven agentic framework for general time series forecasting. The framework comprises four specialized agents: Curator performs LLM-guided diagnostics augmented by external tools that reason over data statistics to choose targeted preprocessing; Planner narrows the hypothesis space of model choice by leveraging multi-modal diagnostics and self-planning over the input; Forecaster performs model fitting and validation and, based on the results, adaptively selects the best model configuration as well as ensemble strategy to make final predictions; and Reporter synthesizes the whole process into a comprehensive, transparent report. With transparent natural-language rationales and comprehensive reports, TSci transforms the forecasting workflow into a white-box system that is both interpretable and extensible across tasks. Empirical results on eight established benchmarks demonstrate that TSci consistently outperforms both statistical and LLM-based baselines, reducing forecast error by an average of 10.4% and 38.2%, respectively. Moreover, TSci produces a clear and rigorous report that makes the forecasting workflow more transparent and interpretable.

We present AstroCLIP, a strategy to facilitate the construction of astronomical foundation models that bridge the gap between diverse observational modalities. We demonstrate that a cross-modal contrastive learning approach between images and optical spectra of galaxies yields highly informative embeddings of both modalities. In particular, we apply our method on multi-band images and optical spectra from the Dark Energy Spectroscopic Instrument (DESI), and show that: (1) these embeddings are well-aligned between modalities and can be used for accurate cross-modal searches, and (2) these embeddings encode valuable physical information about the galaxies -- in particular redshift and stellar mass -- that can be used to achieve competitive zero- and few- shot predictions without further finetuning. Additionally, in the process of developing our approach, we also construct a novel, transformer-based model and pretraining approach for processing galaxy spectra.

Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the leading cause of dementia, significantly impacting cost, mortality, and burden worldwide. The advent of high-throughput omics technologies, such as genomics, transcriptomics, proteomics, and epigenomics, has revolutionized the molecular understanding of AD. Conventional AI approaches typically require the completion of all omics data at the outset to achieve optimal AD diagnosis, which are inefficient and may be unnecessary. To reduce the clinical cost and improve the accuracy of AD diagnosis using multi-omics data, we propose a novel staged graph convolutional network with uncertainty quantification (SGUQ). SGUQ begins with mRNA and progressively incorporates DNA methylation and miRNA data only when necessary, reducing overall costs and exposure to harmful tests. Experimental results indicate that 46.23% of the samples can be reliably predicted using only single-modal omics data (mRNA), while an additional 16.04% of the samples can achieve reliable predictions when combining two omics data types (mRNA + DNA methylation). In addition, the proposed staged SGUQ achieved an accuracy of 0.858 on ROSMAP dataset, which outperformed existing methods significantly. The proposed SGUQ can not only be applied to AD diagnosis using multi-omics data but also has the potential for clinical decision-making using multi-viewed data. Our implementation is publicly available at https://github.com/chenzhao2023/multiomicsuncertainty.

Click-through rate (CTR) prediction is a crucial issue in recommendation systems. There has been an emergence of various public CTR datasets. However, existing datasets primarily suffer from the following limitations. Firstly, users generally click different types of items from multiple scenarios, and modeling from multiple scenarios can provide a more comprehensive understanding of users. Existing datasets only include data for the same type of items from a single scenario. Secondly, multi-modal features are essential in multi-scenario prediction as they address the issue of inconsistent ID encoding between different scenarios. The existing datasets are based on ID features and lack multi-modal features. Third, a large-scale dataset can provide a more reliable evaluation of models, fully reflecting the performance differences between models. The scale of existing datasets is around 100 million, which is relatively small compared to the real-world CTR prediction. To address these limitations, we propose AntM^{2}C, a Multi-Scenario Multi-Modal CTR dataset based on industrial data from Alipay. Specifically, AntM^{2}C provides the following advantages: 1) It covers CTR data of 5 different types of items, providing insights into the preferences of users for different items, including advertisements, vouchers, mini-programs, contents, and videos. 2) Apart from ID-based features, AntM^{2}C also provides 2 multi-modal features, raw text and image features, which can effectively establish connections between items with different IDs. 3) AntM^{2}C provides 1 billion CTR data with 200 features, including 200 million users and 6 million items. It is currently the largest-scale CTR dataset available. Based on AntM^{2}C, we construct several typical CTR tasks and provide comparisons with baseline methods. The dataset homepage is available at https://www.atecup.cn/home.

Multi-agent trajectory prediction at signalized intersections is crucial for developing efficient intelligent transportation systems and safe autonomous driving systems. Due to the complexity of intersection scenarios and the limitations of single-vehicle perception, the performance of vehicle-centric prediction methods has reached a plateau. In this paper, we introduce an Infrastructure-to-Everything (I2X) collaborative prediction scheme. In this scheme, roadside units (RSUs) independently forecast the future trajectories of all vehicles and transmit these predictions unidirectionally to subscribing vehicles. Building on this scheme, we propose I2XTraj, a dedicated infrastructure-based trajectory prediction model. I2XTraj leverages real-time traffic signal states, prior maneuver strategy knowledge, and multi-agent interactions to generate accurate, joint multi-modal trajectory prediction. First, a continuous signal-informed mechanism is proposed to adaptively process real-time traffic signals to guide trajectory proposal generation under varied intersection configurations. Second, a driving strategy awareness mechanism estimates the joint distribution of maneuver strategies by integrating spatial priors of intersection areas with dynamic vehicle states, enabling coverage of the full set of feasible maneuvers. Third, a spatial-temporal-mode attention network models multi-agent interactions to refine and adjust joint trajectory outputs.Finally, I2XTraj is evaluated on two real-world datasets of signalized intersections, the V2X-Seq and the SinD drone dataset. In both single-infrastructure and online collaborative scenarios, our model outperforms state-of-the-art methods by over 30\% on V2X-Seq and 15\% on SinD, demonstrating strong generalizability and robustness.

We present a novel multi-modal unspoken punctuation prediction system for the English language which combines acoustic and text features. We demonstrate for the first time, that by relying exclusively on synthetic data generated using a prosody-aware text-to-speech system, we can outperform a model trained with expensive human audio recordings on the unspoken punctuation prediction problem. Our model architecture is well suited for on-device use. This is achieved by leveraging hash-based embeddings of automatic speech recognition text output in conjunction with acoustic features as input to a quasi-recurrent neural network, keeping the model size small and latency low.

3D occupancy prediction is crucial for autonomous driving perception. Fusion of 4D radar and camera provides a potential solution of robust occupancy prediction on serve weather with least cost. How to achieve effective multi-modal feature fusion and reduce annotation costs remains significant challenges. In this work, we propose MetaOcc, a novel multi-modal occupancy prediction framework that fuses surround-view cameras and 4D radar for comprehensive environmental perception. We first design a height self-attention module for effective 3D feature extraction from sparse radar points. Then, a local-global fusion mechanism is proposed to adaptively capture modality contributions while handling spatio-temporal misalignments. Temporal alignment and fusion module is employed to further aggregate historical feature. Furthermore, we develop a semi-supervised training procedure leveraging open-set segmentor and geometric constraints for pseudo-label generation, enabling robust perception with limited annotations. Extensive experiments on OmniHD-Scenes dataset demonstrate that MetaOcc achieves state-of-the-art performance, surpassing previous methods by significant margins. Notably, as the first semi-supervised 4D radar and camera fusion-based occupancy prediction approach, MetaOcc maintains 92.5% of the fully-supervised performance while using only 50% of ground truth annotations, establishing a new benchmark for multi-modal 3D occupancy prediction. Code and data are available at https://github.com/LucasYang567/MetaOcc.

Accurately anticipating how complex, diverse scenes will evolve requires models that represent uncertainty, simulate along extended interaction chains, and efficiently explore many plausible futures. Yet most existing approaches rely on dense video or latent-space prediction, expending substantial capacity on dense appearance rather than on the underlying sparse trajectories of points in the scene. This makes large-scale exploration of future hypotheses costly and limits performance when long-horizon, multi-modal motion is essential. We address this by formulating the prediction of open-set future scene dynamics as step-wise inference over sparse point trajectories. Our autoregressive diffusion model advances these trajectories through short, locally predictable transitions, explicitly modeling the growth of uncertainty over time. This dynamics-centric representation enables fast rollout of thousands of diverse futures from a single image, optionally guided by initial constraints on motion, while maintaining physical plausibility and long-range coherence. We further introduce OWM, a benchmark for open-set motion prediction based on diverse in-the-wild videos, to evaluate accuracy and variability of predicted trajectory distributions under real-world uncertainty. Our method matches or surpasses dense simulators in predictive accuracy while achieving orders-of-magnitude higher sampling speed, making open-set future prediction both scalable and practical. Project page: http://compvis.github.io/myriad.

3D semantic occupancy prediction is crucial for autonomous driving. While multi-modal fusion improves accuracy over vision-only methods, it typically relies on computationally expensive dense voxel or BEV tensors. We present Gau-Occ, a multi-modal framework that bypasses dense volumetric processing by modeling the scene as a compact collection of semantic 3D Gaussians. To ensure geometric completeness, we propose a LiDAR Completion Diffuser (LCD) that recovers missing structures from sparse LiDAR to initialize robust Gaussian anchors. Furthermore, we introduce Gaussian Anchor Fusion (GAF), which efficiently integrates multi-view image semantics via geometry-aligned 2D sampling and cross-modal alignment. By refining these compact Gaussian descriptors, Gau-Occ captures both spatial consistency and semantic discriminability. Extensive experiments across challenging benchmarks demonstrate that Gau-Occ achieves state-of-the-art performance with significant computational efficiency.

An emerging solution for explaining Transformer-based models is to use vector-based analysis on how the representations are formed. However, providing a faithful vector-based explanation for a multi-layer model could be challenging in three aspects: (1) Incorporating all components into the analysis, (2) Aggregating the layer dynamics to determine the information flow and mixture throughout the entire model, and (3) Identifying the connection between the vector-based analysis and the model's predictions. In this paper, we present DecompX to tackle these challenges. DecompX is based on the construction of decomposed token representations and their successive propagation throughout the model without mixing them in between layers. Additionally, our proposal provides multiple advantages over existing solutions for its inclusion of all encoder components (especially nonlinear feed-forward networks) and the classification head. The former allows acquiring precise vectors while the latter transforms the decomposition into meaningful prediction-based values, eliminating the need for norm- or summation-based vector aggregation. According to the standard faithfulness evaluations, DecompX consistently outperforms existing gradient-based and vector-based approaches on various datasets. Our code is available at https://github.com/mohsenfayyaz/DecompX.

We present a novel approach for the prediction of anticancer compound sensitivity by means of multi-modal attention-based neural networks (PaccMann). In our approach, we integrate three key pillars of drug sensitivity, namely, the molecular structure of compounds, transcriptomic profiles of cancer cells as well as prior knowledge about interactions among proteins within cells. Our models ingest a drug-cell pair consisting of SMILES encoding of a compound and the gene expression profile of a cancer cell and predicts an IC50 sensitivity value. Gene expression profiles are encoded using an attention-based encoding mechanism that assigns high weights to the most informative genes. We present and study three encoders for SMILES string of compounds: 1) bidirectional recurrent 2) convolutional 3) attention-based encoders. We compare our devised models against a baseline model that ingests engineered fingerprints to represent the molecular structure. We demonstrate that using our attention-based encoders, we can surpass the baseline model. The use of attention-based encoders enhance interpretability and enable us to identify genes, bonds and atoms that were used by the network to make a prediction.

Accurate prediction of traffic accident severity is critical for improving road safety, optimizing emergency response strategies, and informing the design of safer transportation infrastructure. However, existing approaches often struggle to effectively model the intricate interdependencies among spatial, temporal, and contextual variables that govern accident outcomes. In this study, we introduce STARN-GAT, a Multi-Modal Spatio-Temporal Graph Attention Network, which leverages adaptive graph construction and modality-aware attention mechanisms to capture these complex relationships. Unlike conventional methods, STARN-GAT integrates road network topology, temporal traffic patterns, and environmental context within a unified attention-based framework. The model is evaluated on the Fatality Analysis Reporting System (FARS) dataset, achieving a Macro F1-score of 85 percent, ROC-AUC of 0.91, and recall of 81 percent for severe incidents. To ensure generalizability within the South Asian context, STARN-GAT is further validated on the ARI-BUET traffic accident dataset, where it attains a Macro F1-score of 0.84, recall of 0.78, and ROC-AUC of 0.89. These results demonstrate the model's effectiveness in identifying high-risk cases and its potential for deployment in real-time, safety-critical traffic management systems. Furthermore, the attention-based architecture enhances interpretability, offering insights into contributing factors and supporting trust in AI-assisted decision-making. Overall, STARN-GAT bridges the gap between advanced graph neural network techniques and practical applications in road safety analytics.

Discontinuing ad creatives at an appropriate time is one of the most important ad operations that can have a significant impact on sales. Such operational support for ineffective ads has been less explored than that for effective ads. After pre-analyzing 1,000,000 real-world ad creatives, we found that there are two types of discontinuation: short-term (i.e., cut-out) and long-term (i.e., wear-out). In this paper, we propose a practical prediction framework for the discontinuation of ad creatives with a hazard function-based loss function inspired by survival analysis. Our framework predicts the discontinuations with a multi-modal deep neural network that takes as input the ad creative (e.g., text, categorical, image, numerical features). To improve the prediction performance for the two different types of discontinuations and for the ad creatives that contribute to sales, we introduce two new techniques: (1) a two-term estimation technique with multi-task learning and (2) a click-through rate-weighting technique for the loss function. We evaluated our framework using the large-scale ad creative dataset, including 10 billion scale impressions. In terms of the concordance index (short: 0.896, long: 0.939, and overall: 0.792), our framework achieved significantly better performance than the conventional method (0.531). Additionally, we confirmed that our framework (i) demonstrated the same degree of discontinuation effect as manual operations for short-term cases, and (ii) accurately predicted the ad discontinuation order, which is important for long-running ad creatives for long-term cases.

Understanding protein solubility is essential for their functional applications. Computational methods for predicting protein solubility are crucial for reducing experimental costs and enhancing the efficiency and success rates of protein engineering. Existing methods either construct a supervised learning scheme on small-scale datasets with manually processed physicochemical properties, or blindly apply pre-trained protein language models to extract amino acid interaction information. The scale and quality of available training datasets leave significant room for improvement in terms of accuracy and generalization. To address these research gaps, we propose \sol, a novel deep learning method that combines pre-training and fine-tuning schemes for protein solubility prediction. ProtSolM integrates information from multiple dimensions, including physicochemical properties, amino acid sequences, and protein backbone structures. Our model is trained using \data, the largest solubility dataset that we have constructed. PDBSol includes over 60,000 protein sequences and structures. We provide a comprehensive leaderboard of existing statistical learning and deep learning methods on independent datasets with computational and experimental labels. ProtSolM achieved state-of-the-art performance across various evaluation metrics, demonstrating its potential to significantly advance the accuracy of protein solubility prediction.

Knee Osteoarthritis (KOA) is a highly prevalent chronic musculoskeletal condition with no currently available treatment. The manifestation of KOA is heterogeneous and prediction of its progression is challenging. Current literature suggests that the use of multi-modal data and advanced modeling methods, such as the ones based on Deep Learning, has promise in tackling this challenge. To date, however, the evidence on the efficacy of this approach is limited. In this study, we leveraged recent advances in Deep Learning and, using a Transformer approach, developed a unified framework for the multi-modal fusion of knee imaging data. Subsequently, we analyzed its performance across a range of scenarios by investigating multiple progression horizons -- from short-term to long-term. We report our findings using a large cohort (n=2421-3967) derived from the Osteoarthritis Initiative dataset. We show that structural knee MRI allows identifying radiographic KOA progressors on par with multi-modal fusion approaches, achieving an area under the ROC curve (ROC AUC) of 0.70-0.76 and Average Precision (AP) of 0.15-0.54 in 2-8 year horizons. Progression within 1 year was better predicted with a multi-modal method using X-ray, structural, and compositional MR images -- ROC AUC of 0.76(0.04), AP of 0.13(0.04) -- or via clinical data. Our follow-up analysis generally shows that prediction from the imaging data is more accurate for post-traumatic subjects, and we further investigate which subject subgroups may benefit the most. The present study provides novel insights into multi-modal imaging of KOA and brings a unified data-driven framework for studying its progression in an end-to-end manner, providing new tools for the design of more efficient clinical trials. The source code of our framework and the pre-trained models are made publicly available.

Understanding where people go after visiting one business is crucial for urban planning, retail analytics, and location-based services. However, predicting these co-visitation patterns across millions of venues remains challenging due to extreme data sparsity and the complex interplay between spatial proximity and business relationships. Traditional approaches using only geographic distance fail to capture why coffee shops attract different customer flows than fine dining restaurants, even when co-located. We introduce NAICS-aware GraphSAGE, a novel graph neural network that integrates business taxonomy knowledge through learnable embeddings to predict population-scale co-visitation patterns. Our key insight is that business semantics, captured through detailed industry codes, provide crucial signals that pure spatial models cannot explain. The approach scales to massive datasets (4.2 billion potential venue pairs) through efficient state-wise decomposition while combining spatial, temporal, and socioeconomic features in an end-to-end framework. Evaluated on our POI-Graph dataset comprising 94.9 million co-visitation records across 92,486 brands and 48 US states, our method achieves significant improvements over state-of-the-art baselines: the R-squared value increases from 0.243 to 0.625 (a 157 percent improvement), with strong gains in ranking quality (32 percent improvement in NDCG at 10).

Multi-sensor ML models for EO aim to enhance prediction accuracy by integrating data from various sources. However, the presence of missing data poses a significant challenge, particularly in non-persistent sensors that can be affected by external factors. Existing literature has explored strategies like temporal dropout and sensor-invariant models to address the generalization to missing data issues. Inspired by these works, we study two novel methods tailored for multi-sensor scenarios, namely Input Sensor Dropout (ISensD) and Ensemble Sensor Invariant (ESensI). Through experimentation on three multi-sensor temporal EO datasets, we demonstrate that these methods effectively increase the robustness of model predictions to missing sensors. Particularly, we focus on how the predictive performance of models drops when sensors are missing at different levels. We observe that ensemble multi-sensor models are the most robust to the lack of sensors. In addition, the sensor dropout component in ISensD shows promising robustness results.

Financial trading has been a challenging task, as it requires the integration of vast amounts of data from various modalities. Traditional deep learning and reinforcement learning methods require large training data and often involve encoding various data types into numerical formats for model input, which limits the explainability of model behavior. Recently, LLM-based agents have demonstrated remarkable advancements in handling multi-modal data, enabling them to execute complex, multi-step decision-making tasks while providing insights into their thought processes. This research introduces a multi-modal multi-agent system designed specifically for financial trading tasks. Our framework employs a team of specialized LLM-based agents, each adept at processing and interpreting various forms of financial data, such as textual news reports, candlestick charts, and trading signal charts. A key feature of our approach is the integration of a reflection module, which conducts analyses of historical trading signals and their outcomes. This reflective process is instrumental in enhancing the decision-making capabilities of the system for future trading scenarios. Furthermore, the ablation studies indicate that the visual reflection module plays a crucial role in enhancing the decision-making capabilities of our framework.

Realistic simulation of dynamic scenes requires accurately capturing diverse material properties and modeling complex object interactions grounded in physical principles. However, existing methods are constrained to basic material types with limited predictable parameters, making them insufficient to represent the complexity of real-world materials. We introduce a novel approach that leverages multi-modal foundation models and video diffusion to achieve enhanced 4D dynamic scene simulation. Our method utilizes multi-modal models to identify material types and initialize material parameters through image queries, while simultaneously inferring 3D Gaussian splats for detailed scene representation. We further refine these material parameters using video diffusion with a differentiable Material Point Method (MPM) and optical flow guidance rather than render loss or Score Distillation Sampling (SDS) loss. This integrated framework enables accurate prediction and realistic simulation of dynamic interactions in real-world scenarios, advancing both accuracy and flexibility in physics-based simulations.

We introduce MQ-Det, an efficient architecture and pre-training strategy design to utilize both textual description with open-set generalization and visual exemplars with rich description granularity as category queries, namely, Multi-modal Queried object Detection, for real-world detection with both open-vocabulary categories and various granularity. MQ-Det incorporates vision queries into existing well-established language-queried-only detectors. A plug-and-play gated class-scalable perceiver module upon the frozen detector is proposed to augment category text with class-wise visual information. To address the learning inertia problem brought by the frozen detector, a vision conditioned masked language prediction strategy is proposed. MQ-Det's simple yet effective architecture and training strategy design is compatible with most language-queried object detectors, thus yielding versatile applications. Experimental results demonstrate that multi-modal queries largely boost open-world detection. For instance, MQ-Det significantly improves the state-of-the-art open-set detector GLIP by +7.8% AP on the LVIS benchmark via multi-modal queries without any downstream finetuning, and averagely +6.3% AP on 13 few-shot downstream tasks, with merely additional 3% modulating time required by GLIP. Code is available at https://github.com/YifanXu74/MQ-Det.

We present a multi-modal foundation model for astrophysical galaxy data, designed to map between simulation- and observation-based galactic features. Our encoder-only transformer flexibly ingests scalar quantities (e.g., redshifts, galaxy masses) and vectors (e.g., star formation histories, spectra), supporting multi-task training that includes within-modality reconstruction and cross-modality prediction. With a dynamic masking strategy, the model can query arbitrary galaxy properties from partial inputs -- including predicting spectra from redshift and mass, or estimating photometric redshifts from broadband magnitudes -- while also recovering missing segments within a modality. Trained on 185,000 simulated galaxies from a gigaparsec-scale Cosmology simulation, the model yields a 50% improvement in redshift estimation when combining LSST and SPHEREx photometry over LSST photometry alone, and a 63% improvement in stellar mass inference when combining late-time SFH with LSST photometry over early-time SFH with LSST photometry. The model demonstrates strong generalization across multi-modal tasks and lays the groundwork for future integration of higher-dimensional and structured data such as images, merger trees, and 3D fields. This approach provides a unified framework for connecting simulations and observations, advancing the development of generalizable astrophysical foundation models.

During surgical training, real-time feedback from trainers to trainees is important for preventing errors and enhancing long-term skill acquisition. Accurately predicting the effectiveness of this feedback, specifically whether it leads to a change in trainee behavior, is crucial for developing methods for improving surgical training and education. However, relying on human annotations to assess feedback effectiveness is laborious and prone to biases, underscoring the need for an automated, scalable, and objective method. Creating such an automated system poses challenges, as it requires an understanding of both the verbal feedback delivered by the trainer and the visual context of the real-time surgical scene. To address this, we propose a method that integrates information from transcribed verbal feedback and corresponding surgical video to predict feedback effectiveness. Our findings show that both transcribed feedback and surgical video are individually predictive of trainee behavior changes, and their combination achieves an AUROC of 0.70+/-0.02, improving prediction accuracy by up to 6.6%. Additionally, we introduce self-supervised fine-tuning as a strategy for enhancing surgical video representation learning, which is scalable and further enhances prediction performance. Our results demonstrate the potential of multi-modal learning to advance the automated assessment of surgical feedback.

Multi-modal multi-party conversation (MMC) is a less studied yet important topic of research due to that it well fits real-world scenarios and thus potentially has more widely-used applications. Compared with the traditional multi-modal conversations, MMC requires stronger character-centered understanding abilities as there are many interlocutors appearing in both the visual and textual context. To facilitate the study of this problem, we present Friends-MMC in this paper, an MMC dataset that contains 24,000+ unique utterances paired with video context. To explore the character-centered understanding of the dialogue, we also annotate the speaker of each utterance, the names and bounding bboxes of faces that appear in the video. Based on this Friends-MMC dataset, we further study two fundamental MMC tasks: conversation speaker identification and conversation response prediction, both of which have the multi-party nature with the video or image as visual context. For conversation speaker identification, we demonstrate the inefficiencies of existing methods such as pre-trained models, and propose a simple yet effective baseline method that leverages an optimization solver to utilize the context of two modalities to achieve better performance. For conversation response prediction, we fine-tune generative dialogue models on Friend-MMC, and analyze the benefits of speaker information. The code and dataset is publicly available at https://github.com/yellow-binary-tree/Friends-MMC and thus we call for more attention on modeling speaker information when understanding conversations.

Multi-modal fusion approaches aim to integrate information from different data sources. Unlike natural datasets, such as in audio-visual applications, where samples consist of "paired" modalities, data in healthcare is often collected asynchronously. Hence, requiring the presence of all modalities for a given sample is not realistic for clinical tasks and significantly limits the size of the dataset during training. In this paper, we propose MedFuse, a conceptually simple yet promising LSTM-based fusion module that can accommodate uni-modal as well as multi-modal input. We evaluate the fusion method and introduce new benchmark results for in-hospital mortality prediction and phenotype classification, using clinical time-series data in the MIMIC-IV dataset and corresponding chest X-ray images in MIMIC-CXR. Compared to more complex multi-modal fusion strategies, MedFuse provides a performance improvement by a large margin on the fully paired test set. It also remains robust across the partially paired test set containing samples with missing chest X-ray images. We release our code for reproducibility and to enable the evaluation of competing models in the future.

Task-oriented dialogue (TOD) systems have been widely used by mobile phone intelligent assistants to accomplish tasks such as calendar scheduling or hotel reservation. Current TOD systems usually focus on multi-turn text/speech interaction, then they would call back-end APIs designed for TODs to perform the task. However, this API-based architecture greatly limits the information-searching capability of intelligent assistants and may even lead to task failure if TOD-specific APIs are not available or the task is too complicated to be executed by the provided APIs. In this paper, we propose a new TOD architecture: GUI-based task-oriented dialogue system (GUI-TOD). A GUI-TOD system can directly perform GUI operations on real APPs and execute tasks without invoking TOD-specific backend APIs. Furthermore, we release META-GUI, a dataset for training a Multi-modal convErsaTional Agent on mobile GUI. We also propose a multi-model action prediction and response model, which show promising results on META-GUI. The dataset, codes and leaderboard are publicly available.

We present Visuelle 2.0, the first dataset useful for facing diverse prediction problems that a fast-fashion company has to manage routinely. Furthermore, we demonstrate how the use of computer vision is substantial in this scenario. Visuelle 2.0 contains data for 6 seasons / 5355 clothing products of Nuna Lie, a famous Italian company with hundreds of shops located in different areas within the country. In particular, we focus on a specific prediction problem, namely short-observation new product sale forecasting (SO-fore). SO-fore assumes that the season has started and a set of new products is on the shelves of the different stores. The goal is to forecast the sales for a particular horizon, given a short, available past (few weeks), since no earlier statistics are available. To be successful, SO-fore approaches should capture this short past and exploit other modalities or exogenous data. To these aims, Visuelle 2.0 is equipped with disaggregated data at the item-shop level and multi-modal information for each clothing item, allowing computer vision approaches to come into play. The main message that we deliver is that the use of image data with deep networks boosts performances obtained when using the time series in long-term forecasting scenarios, ameliorating the WAPE and MAE by up to 5.48% and 7% respectively compared to competitive baseline methods. The dataset is available at https://humaticslab.github.io/forecasting/visuelle

Multimodal Large Language Models (MLLMs) have experienced rapid development in recent years. However, in the financial domain, there is a notable lack of effective and specialized multimodal evaluation datasets. To advance the development of MLLMs in the finance domain, we introduce FinMME, encompassing more than 11,000 high-quality financial research samples across 18 financial domains and 6 asset classes, featuring 10 major chart types and 21 subtypes. We ensure data quality through 20 annotators and carefully designed validation mechanisms. Additionally, we develop FinScore, an evaluation system incorporating hallucination penalties and multi-dimensional capability assessment to provide an unbiased evaluation. Extensive experimental results demonstrate that even state-of-the-art models like GPT-4o exhibit unsatisfactory performance on FinMME, highlighting its challenging nature. The benchmark exhibits high robustness with prediction variations under different prompts remaining below 1%, demonstrating superior reliability compared to existing datasets. Our dataset and evaluation protocol are available at https://huggingface.co/datasets/luojunyu/FinMME and https://github.com/luo-junyu/FinMME.

In recent years, the application of multimodal large language models (MLLM) in various fields has achieved remarkable success. However, as the foundation model for many downstream tasks, current MLLMs are composed of the well-known Transformer network, which has a less efficient quadratic computation complexity. To improve the efficiency of such basic models, we propose Cobra, a linear computational complexity MLLM. Specifically, Cobra integrates the efficient Mamba language model into the visual modality. Moreover, we explore and study various modal fusion schemes to create an effective multi-modal Mamba. Extensive experiments demonstrate that (1) Cobra achieves extremely competitive performance with current computationally efficient state-of-the-art methods, e.g., LLaVA-Phi, TinyLLaVA, and MobileVLM v2, and has faster speed due to Cobra's linear sequential modeling. (2) Interestingly, the results of closed-set challenging prediction benchmarks show that Cobra performs well in overcoming visual illusions and spatial relationship judgments. (3) Notably, Cobra even achieves comparable performance to LLaVA with about 43% of the number of parameters. We will make all codes of Cobra open-source and hope that the proposed method can facilitate future research on complexity problems in MLLM. Our project page is available at: https://sites.google.com/view/cobravlm.

We expose a significant popularity bias in state-of-the-art vision-language models (VLMs), which achieve up to 34% higher accuracy on famous buildings compared to ordinary ones, indicating a reliance on memorization over generalizable understanding. To systematically investigate this, we introduce the largest open benchmark for this task: the YearGuessr dataset, a collection of 55,546 building images with multi-modal attributes from 157 countries, annotated with continuous ordinal labels of their construction year (1001-2024), GPS data, and page-view counts as a proxy for popularity. Using this dataset, we frame the construction year prediction task as ordinal regression and introduce popularity-aware interval accuracy metrics to quantify this bias. Our resulting benchmark of 30+ models, including our YearCLIP model, confirms that VLMs excel on popular, memorized items but struggle significantly with unrecognized subjects, exposing a critical flaw in their reasoning capabilities. Project page: https://sytwu.github.io/BeyondMemo/

Large language models excel at interpreting complex natural language instructions, enabling them to perform a wide range of tasks. In the life sciences, single-cell RNA sequencing (scRNA-seq) data serves as the "language of cellular biology", capturing intricate gene expression patterns at the single-cell level. However, interacting with this "language" through conventional tools is often inefficient and unintuitive, posing challenges for researchers. To address these limitations, we present InstructCell, a multi-modal AI copilot that leverages natural language as a medium for more direct and flexible single-cell analysis. We construct a comprehensive multi-modal instruction dataset that pairs text-based instructions with scRNA-seq profiles from diverse tissues and species. Building on this, we develop a multi-modal cell language architecture capable of simultaneously interpreting and processing both modalities. InstructCell empowers researchers to accomplish critical tasks-such as cell type annotation, conditional pseudo-cell generation, and drug sensitivity prediction-using straightforward natural language commands. Extensive evaluations demonstrate that InstructCell consistently meets or exceeds the performance of existing single-cell foundation models, while adapting to diverse experimental conditions. More importantly, InstructCell provides an accessible and intuitive tool for exploring complex single-cell data, lowering technical barriers and enabling deeper biological insights.

Quality analysis of weather forecasts is an essential topic in meteorology. Although traditional score-based evaluation metrics can quantify certain forecast errors, they are still far from meteorological experts in terms of descriptive capability, interpretability, and understanding of dynamic evolution. With the rapid development of Multi-modal Large Language Models (MLLMs), these models become potential tools to overcome the above challenges. In this work, we introduce an MLLM-based weather forecast analysis method, RadarQA, integrating key physical attributes with detailed assessment reports. We introduce a novel and comprehensive task paradigm for multi-modal quality analysis, encompassing both single frame and sequence, under both rating and assessment scenarios. To support training and benchmarking, we design a hybrid annotation pipeline that combines human expert labeling with automated heuristics. With such an annotation method, we construct RQA-70K, a large-scale dataset with varying difficulty levels for radar forecast quality evaluation. We further design a multi-stage training strategy that iteratively improves model performance at each stage. Extensive experiments show that RadarQA outperforms existing general MLLMs across all evaluation settings, highlighting its potential for advancing quality analysis in weather prediction.

Focused Ultrasound Ablation Surgery (FUAS) has emerged as a promising non-invasive therapeutic modality, valued for its safety and precision. Nevertheless, its clinical implementation entails intricate tasks such as multimodal image interpretation, personalized dose planning, and real-time intraoperative decision-making processes that demand intelligent assistance to improve efficiency and reliability. We introduce FUAS-Agents, an autonomous agent system that leverages the multimodal understanding and tool-using capabilities of large language models (LLMs). By integrating patient profiles and MRI data, FUAS-Agents orchestrates a suite of specialized medical AI tools, including segmentation, treatment dose prediction, and clinical guideline retrieval, to generate personalized treatment plans comprising MRI image, dose parameters, and therapeutic strategies. We evaluate the system in a uterine fibroid treatment scenario. Human assessment by four senior FUAS experts indicates that 82.5%, 82.5%, 87.5%, and 97.5% of the generated plans were rated 4 or above (on a 5-point scale) in terms of completeness, accuracy, fluency, and clinical compliance, respectively. These results demonstrate the potential of LLM-driven agents in enhancing decision-making across complex clinical workflows, and exemplify a translational paradigm that combines general-purpose models with specialized expert systems to solve practical challenges in vertical healthcare domains.

Multi-modal large language models (MLLMs) have achieved remarkable success in image- and region-level remote sensing (RS) image understanding tasks, such as image captioning, visual question answering, and visual grounding. However, existing RS MLLMs lack the pixel-level dialogue capability, which involves responding to user instructions with segmentation masks for specific instances. In this paper, we propose GeoPix, a RS MLLM that extends image understanding capabilities to the pixel level. This is achieved by equipping the MLLM with a mask predictor, which transforms visual features from the vision encoder into masks conditioned on the LLM's segmentation token embeddings. To facilitate the segmentation of multi-scale objects in RS imagery, a class-wise learnable memory module is integrated into the mask predictor to capture and store class-wise geo-context at the instance level across the entire dataset. In addition, to address the absence of large-scale datasets for training pixel-level RS MLLMs, we construct the GeoPixInstruct dataset, comprising 65,463 images and 140,412 instances, with each instance annotated with text descriptions, bounding boxes, and masks. Furthermore, we develop a two-stage training strategy to balance the distinct requirements of text generation and masks prediction in multi-modal multi-task optimization. Extensive experiments verify the effectiveness and superiority of GeoPix in pixel-level segmentation tasks, while also maintaining competitive performance in image- and region-level benchmarks.

Multi-hop query answering over a Knowledge Graph (KG) involves traversing one or more hops from the start node to answer a query. Path-based and logic-based methods are state-of-the-art for multi-hop question answering. The former is used in link prediction tasks. The latter is for answering complex logical queries. The logical multi-hop querying technique embeds the KG and queries in the same embedding space. The existing work incorporates First Order Logic (FOL) operators, such as conjunction (wedge), disjunction (vee), and negation (neg), in queries. Though current models have most of the building blocks to execute the FOL queries, they cannot use the dense information of multi-modal entities in the case of Multi-Modal Knowledge Graphs (MMKGs). We propose RConE, an embedding method to capture the multi-modal information needed to answer a query. The model first shortlists candidate (multi-modal) entities containing the answer. It then finds the solution (sub-entities) within those entities. Several existing works tackle path-based question-answering in MMKGs. However, to our knowledge, we are the first to introduce logical constructs in querying MMKGs and to answer queries that involve sub-entities of multi-modal entities as the answer. Extensive evaluation of four publicly available MMKGs indicates that RConE outperforms the current state-of-the-art.

Predicting diverse human motions given a sequence of historical poses has received increasing attention. Despite rapid progress, existing work captures the multi-modal nature of human motions primarily through likelihood-based sampling, where the mode collapse has been widely observed. In this paper, we propose a simple yet effective approach that disentangles randomly sampled codes with a deterministic learnable component named anchors to promote sample precision and diversity. Anchors are further factorized into spatial anchors and temporal anchors, which provide attractively interpretable control over spatial-temporal disparity. In principle, our spatial-temporal anchor-based sampling (STARS) can be applied to different motion predictors. Here we propose an interaction-enhanced spatial-temporal graph convolutional network (IE-STGCN) that encodes prior knowledge of human motions (e.g., spatial locality), and incorporate the anchors into it. Extensive experiments demonstrate that our approach outperforms state of the art in both stochastic and deterministic prediction, suggesting it as a unified framework for modeling human motions. Our code and pretrained models are available at https://github.com/Sirui-Xu/STARS.

We introduce HY-World 2.0, a multi-modal world model framework that advances our prior project HY-World 1.0. HY-World 2.0 accommodates diverse input modalities, including text prompts, single-view images, multi-view images, and videos, and produces 3D world representations. With text or single-view image inputs, the model performs world generation, synthesizing high-fidelity, navigable 3D Gaussian Splatting (3DGS) scenes. This is achieved through a four-stage method: a) Panorama Generation with HY-Pano 2.0, b) Trajectory Planning with WorldNav, c) World Expansion with WorldStereo 2.0, and d) World Composition with WorldMirror 2.0. Specifically, we introduce key innovations to enhance panorama fidelity, enable 3D scene understanding and planning, and upgrade WorldStereo, our keyframe-based view generation model with consistent memory. We also upgrade WorldMirror, a feed-forward model for universal 3D prediction, by refining model architecture and learning strategy, enabling world reconstruction from multi-view images or videos. Also, we introduce WorldLens, a high-performance 3DGS rendering platform featuring a flexible engine-agnostic architecture, automatic IBL lighting, efficient collision detection, and training-rendering co-design, enabling interactive exploration of 3D worlds with character support. Extensive experiments demonstrate that HY-World 2.0 achieves state-of-the-art performance on several benchmarks among open-source approaches, delivering results comparable to the closed-source model Marble. We release all model weights, code, and technical details to facilitate reproducibility and support further research on 3D world models.

Accurate prediction of molecular properties is essential in drug discovery and related fields. However, existing graph neural networks (GNNs) often struggle to simultaneously capture both local and global molecular structures. In this work, we propose a Multi-Level Fusion Graph Neural Network (MLFGNN) that integrates Graph Attention Networks and a novel Graph Transformer to jointly model local and global dependencies. In addition, we incorporate molecular fingerprints as a complementary modality and introduce a mechanism of interaction between attention to adaptively fuse information across representations. Extensive experiments on multiple benchmark datasets demonstrate that MLFGNN consistently outperforms state-of-the-art methods in both classification and regression tasks. Interpretability analysis further reveals that the model effectively captures task-relevant chemical patterns, supporting the usefulness of multi-level and multi-modal fusion in molecular representation learning.

Recently, textual prompt tuning has shown inspirational performance in adapting Contrastive Language-Image Pre-training (CLIP) models to natural image quality assessment. However, such uni-modal prompt learning method only tunes the language branch of CLIP models. This is not enough for adapting CLIP models to AI generated image quality assessment (AGIQA) since AGIs visually differ from natural images. In addition, the consistency between AGIs and user input text prompts, which correlates with the perceptual quality of AGIs, is not investigated to guide AGIQA. In this letter, we propose vision-language consistency guided multi-modal prompt learning for blind AGIQA, dubbed CLIP-AGIQA. Specifically, we introduce learnable textual and visual prompts in language and vision branches of CLIP models, respectively. Moreover, we design a text-to-image alignment quality prediction task, whose learned vision-language consistency knowledge is used to guide the optimization of the above multi-modal prompts. Experimental results on two public AGIQA datasets demonstrate that the proposed method outperforms state-of-the-art quality assessment models. The source code is available at https://github.com/JunFu1995/CLIP-AGIQA.

We introduce Transfusion, a recipe for training a multi-modal model over discrete and continuous data. Transfusion combines the language modeling loss function (next token prediction) with diffusion to train a single transformer over mixed-modality sequences. We pretrain multiple Transfusion models up to 7B parameters from scratch on a mixture of text and image data, establishing scaling laws with respect to a variety of uni- and cross-modal benchmarks. Our experiments show that Transfusion scales significantly better than quantizing images and training a language model over discrete image tokens. By introducing modality-specific encoding and decoding layers, we can further improve the performance of Transfusion models, and even compress each image to just 16 patches. We further demonstrate that scaling our Transfusion recipe to 7B parameters and 2T multi-modal tokens produces a model that can generate images and text on a par with similar scale diffusion models and language models, reaping the benefits of both worlds.

Time series data is ubiquitous in real-world scenarios and crucial for critical applications ranging from energy management to traffic control. Consequently, the ability to reason over time series is a fundamental skill for generalist models to solve practical problems. However, this dimension is notably absent from existing benchmarks of generalist models. To bridge this gap, we introduce TSRBench, a comprehensive multi-modal benchmark designed to stress-test the full spectrum of time series reasoning capabilities. TSRBench features: i) a diverse set of 4125 problems from 14 domains, and is categorized into 4 major dimensions: Perception, Reasoning, Prediction, and Decision-Making. ii) 15 tasks from the 4 dimensions evaluating essential reasoning capabilities (e.g., numerical reasoning). Through extensive experiments, we evaluated over 30 leading proprietary and open-source LLMs, VLMs, and TSLLMs within TSRBench. Our findings reveal that: i) scaling laws hold for perception and reasoning but break down for prediction; ii) strong reasoning does not guarantee accurate context-aware forecasting, indicating a decoupling between semantic understanding and numerical prediction; and iii) despite the complementary nature of textual and visual represenations of time series as inputs, current multimodal models fail to effectively fuse them for reciprocal performance gains. TSRBench provides a standardized evaluation platform that not only highlights existing challenges but also offers valuable insights to advance generalist models. Our code and dataset are available at https://tsrbench.github.io/.

Recent AI advances have enabled multi-modal systems to model and translate diverse information spaces. Extending beyond text and vision, we introduce OneProt, a multi-modal AI for proteins that integrates structural, sequence, alignment, and binding site data. Using the ImageBind framework, OneProt aligns the latent spaces of modality encoders along protein sequences. It demonstrates strong performance in retrieval tasks and surpasses state-of-the-art methods in various downstream tasks, including metal ion binding classification, gene-ontology annotation, and enzyme function prediction. This work expands multi-modal capabilities in protein models, paving the way for applications in drug discovery, biocatalytic reaction planning, and protein engineering.

Developing a universal model that can effectively harness heterogeneous resources and respond to a wide range of personalized needs has been a longstanding community aspiration. Our daily choices, especially in domains like fashion and retail, are substantially shaped by multi-modal data, such as pictures and textual descriptions. These modalities not only offer intuitive guidance but also cater to personalized user preferences. However, the predominant personalization approaches mainly focus on the ID or text-based recommendation problem, failing to comprehend the information spanning various tasks or modalities. In this paper, our goal is to establish a Unified paradigm for Multi-modal Personalization systems (UniMP), which effectively leverages multi-modal data while eliminating the complexities associated with task- and modality-specific customization. We argue that the advancements in foundational generative modeling have provided the flexibility and effectiveness necessary to achieve the objective. In light of this, we develop a generic and extensible personalization generative framework, that can handle a wide range of personalized needs including item recommendation, product search, preference prediction, explanation generation, and further user-guided image generation. Our methodology enhances the capabilities of foundational language models for personalized tasks by seamlessly ingesting interleaved cross-modal user history information, ensuring a more precise and customized experience for users. To train and evaluate the proposed multi-modal personalized tasks, we also introduce a novel and comprehensive benchmark covering a variety of user requirements. Our experiments on the real-world benchmark showcase the model's potential, outperforming competitive methods specialized for each task.

Protein representation learning is critical for numerous biological tasks. Recently, large transformer-based protein language models (pLMs) pretrained on large scale protein sequences have demonstrated significant success in sequence-based tasks. However, pLMs lack structural context. Conversely, graph neural networks (GNNs) designed to leverage 3D structural information have shown promising generalization in protein-related prediction tasks, but their effectiveness is often constrained by the scarcity of labeled structural data. Recognizing that sequence and structural representations are complementary perspectives of the same protein entity, we propose a multimodal bidirectional hierarchical fusion framework to effectively merge these modalities. Our framework employs attention and gating mechanisms to enable effective interaction between pLMs-generated sequential representations and GNN-extracted structural features, improving information exchange and enhancement across layers of the neural network. This bidirectional and hierarchical (Bi-Hierarchical) fusion approach leverages the strengths of both modalities to capture richer and more comprehensive protein representations. Based on the framework, we further introduce local Bi-Hierarchical Fusion with gating and global Bi-Hierarchical Fusion with multihead self-attention approaches. Our method demonstrates consistent improvements over strong baselines and existing fusion techniques in a variety of protein representation learning benchmarks, including enzyme EC classification, model quality assessment, protein-ligand binding affinity prediction, protein-protein binding site prediction, and B cell epitopes prediction. Our method establishes a new state-of-the-art for multimodal protein representation learning, emphasizing the efficacy of Bi-Hierarchical Fusion in bridging sequence and structural modalities.

The perception system for autonomous driving generally requires to handle multiple diverse sub-tasks. However, current algorithms typically tackle individual sub-tasks separately, which leads to low efficiency when aiming at obtaining full-perception results. Some multi-task learning methods try to unify multiple tasks with one model, but do not solve the conflicts in multi-task learning. In this paper, we introduce M3Net, a novel multimodal and multi-task network that simultaneously tackles detection, segmentation, and 3D occupancy prediction for autonomous driving and achieves superior performance than single task model. M3Net takes multimodal data as input and multiple tasks via query-token interactions. To enhance the integration of multi-modal features for multi-task learning, we first propose the Modality-Adaptive Feature Integration (MAFI) module, which enables single-modality features to predict channel-wise attention weights for their high-performing tasks, respectively. Based on integrated features, we then develop task-specific query initialization strategies to accommodate the needs of detection/segmentation and 3D occupancy prediction. Leveraging the properly initialized queries, a shared decoder transforms queries and BEV features layer-wise, facilitating multi-task learning. Furthermore, we propose a Task-oriented Channel Scaling (TCS) module in the decoder to mitigate conflicts between optimizing for different tasks. Additionally, our proposed multi-task querying and TCS module support both Transformer-based decoder and Mamba-based decoder, demonstrating its flexibility to different architectures. M3Net achieves state-of-the-art multi-task learning performance on the nuScenes benchmarks.

Visual grounding is the task of locating objects specified by natural language expressions. Existing methods extend generic object detection frameworks to tackle this task. They typically extract visual and textual features separately using independent visual and textual encoders, then fuse these features in a multi-modal decoder for final prediction. However, visual grounding presents unique challenges. It often involves locating objects with different text descriptions within the same image. Existing methods struggle with this task because the independent visual encoder produces identical visual features for the same image, limiting detection performance. Some recently approaches propose various language-guided visual encoders to address this issue, but they mostly rely solely on textual information and require sophisticated designs. In this paper, we introduce Multi-modal Conditional Adaptation (MMCA), which enables the visual encoder to adaptively update weights, directing its focus towards text-relevant regions. Specifically, we first integrate information from different modalities to obtain multi-modal embeddings. Then we utilize a set of weighting coefficients, which generated from the multimodal embeddings, to reorganize the weight update matrices and apply them to the visual encoder of the visual grounding model. Extensive experiments on four widely used datasets demonstrate that MMCA achieves significant improvements and state-of-the-art results. Ablation experiments further demonstrate the lightweight and efficiency of our method. Our source code is available at: https://github.com/Mr-Bigworth/MMCA.

Foundation models in computational pathology promise to unlock the development of new clinical decision support systems and models for precision medicine. However, there is a mismatch between most clinical analysis, which is defined at the level of one or more whole slide images, and foundation models to date, which process the thousands of image tiles contained in a whole slide image separately. The requirement to train a network to aggregate information across a large number of tiles in multiple whole slide images limits these models' impact. In this work, we present a slide-level foundation model for H&E-stained histopathology, PRISM, that builds on Virchow tile embeddings and leverages clinical report text for pre-training. Using the tile embeddings, PRISM produces slide-level embeddings with the ability to generate clinical reports, resulting in several modes of use. Using text prompts, PRISM achieves zero-shot cancer detection and sub-typing performance approaching and surpassing that of a supervised aggregator model. Using the slide embeddings with linear classifiers, PRISM surpasses supervised aggregator models. Furthermore, we demonstrate that fine-tuning of the PRISM slide encoder yields label-efficient training for biomarker prediction, a task that typically suffers from low availability of training data; an aggregator initialized with PRISM and trained on as little as 10% of the training data can outperform a supervised baseline that uses all of the data.

There is increasing interest in the use of multimodal data in various web applications, such as digital advertising and e-commerce. Typical methods for extracting important information from multimodal data rely on a mid-fusion architecture that combines the feature representations from multiple encoders. However, as the number of modalities increases, several potential problems with the mid-fusion model structure arise, such as an increase in the dimensionality of the concatenated multimodal features and missing modalities. To address these problems, we propose a new concept that considers multimodal inputs as a set of sequences, namely, deep multimodal sequence sets (DM^2S^2). Our set-aware concept consists of three components that capture the relationships among multiple modalities: (a) a BERT-based encoder to handle the inter- and intra-order of elements in the sequences, (b) intra-modality residual attention (IntraMRA) to capture the importance of the elements in a modality, and (c) inter-modality residual attention (InterMRA) to enhance the importance of elements with modality-level granularity further. Our concept exhibits performance that is comparable to or better than the previous set-aware models. Furthermore, we demonstrate that the visualization of the learned InterMRA and IntraMRA weights can provide an interpretation of the prediction results.

The field of 4D world modeling - aiming to jointly capture spatial geometry and temporal dynamics - has witnessed remarkable progress in recent years, driven by advances in large-scale generative models and multimodal learning. However, the development of truly general 4D world models remains fundamentally constrained by the availability of high-quality data. Existing datasets and benchmarks often lack the dynamic complexity, multi-domain diversity, and spatial-temporal annotations required to support key tasks such as 4D geometric reconstruction, future prediction, and camera-control video generation. To address this gap, we introduce OmniWorld, a large-scale, multi-domain, multi-modal dataset specifically designed for 4D world modeling. OmniWorld consists of a newly collected OmniWorld-Game dataset and several curated public datasets spanning diverse domains. Compared with existing synthetic datasets, OmniWorld-Game provides richer modality coverage, larger scale, and more realistic dynamic interactions. Based on this dataset, we establish a challenging benchmark that exposes the limitations of current state-of-the-art (SOTA) approaches in modeling complex 4D environments. Moreover, fine-tuning existing SOTA methods on OmniWorld leads to significant performance gains across 4D reconstruction and video generation tasks, strongly validating OmniWorld as a powerful resource for training and evaluation. We envision OmniWorld as a catalyst for accelerating the development of general-purpose 4D world models, ultimately advancing machines' holistic understanding of the physical world.

Any entity in the visual world can be hierarchically grouped based on shared characteristics and mapped to fine-grained sub-categories. While Multi-modal Large Language Models (MLLMs) achieve strong performance on coarse-grained visual tasks, they often struggle with Fine-Grained Visual Recognition (FGVR). Adapting general-purpose MLLMs to FGVR typically requires large amounts of annotated data, which is costly to obtain, leaving a substantial performance gap compared to contrastive CLIP models dedicated for discriminative tasks. Moreover, MLLMs tend to overfit to seen sub-categories and generalize poorly to unseen ones. To address these challenges, we propose Fine-R1, an MLLM tailored for FGVR through an R1-style training framework: (1) Chain-of-Thought Supervised Fine-tuning, where we construct a high-quality FGVR CoT dataset with rationales of "visual analysis, candidate sub-categories, comparison, and prediction", transition the model into a strong open-world classifier; and (2) Triplet Augmented Policy Optimization, where Intra-class Augmentation mixes trajectories from anchor and positive images within the same category to improve robustness to intra-class variance, while Inter-class Augmentation maximizes the response distinction conditioned on images across sub-categories to enhance discriminative ability. With only 4-shot training, Fine-R1 outperforms existing general MLLMs, reasoning MLLMs, and even contrastive CLIP models in identifying both seen and unseen sub-categories, showing promise in working in knowledge-intensive domains where gathering expert annotations for all sub-categories is arduous. Code is available at https://github.com/PKU-ICST-MIPL/FineR1_ICLR2026.

3D object detection and occupancy prediction are critical tasks in autonomous driving, attracting significant attention. Despite the potential of recent vision-based methods, they encounter challenges under adverse conditions. Thus, integrating cameras with next-generation 4D imaging radar to achieve unified multi-task perception is highly significant, though research in this domain remains limited. In this paper, we propose Doracamom, the first framework that fuses multi-view cameras and 4D radar for joint 3D object detection and semantic occupancy prediction, enabling comprehensive environmental perception. Specifically, we introduce a novel Coarse Voxel Queries Generator that integrates geometric priors from 4D radar with semantic features from images to initialize voxel queries, establishing a robust foundation for subsequent Transformer-based refinement. To leverage temporal information, we design a Dual-Branch Temporal Encoder that processes multi-modal temporal features in parallel across BEV and voxel spaces, enabling comprehensive spatio-temporal representation learning. Furthermore, we propose a Cross-Modal BEV-Voxel Fusion module that adaptively fuses complementary features through attention mechanisms while employing auxiliary tasks to enhance feature quality. Extensive experiments on the OmniHD-Scenes, View-of-Delft (VoD), and TJ4DRadSet datasets demonstrate that Doracamom achieves state-of-the-art performance in both tasks, establishing new benchmarks for multi-modal 3D perception. Code and models will be publicly available.

Oracle bone inscriptions(OBI) is the earliest developed writing system in China, bearing invaluable written exemplifications of early Shang history and paleography. However, the task of deciphering OBI, in the current climate of the scholarship, can prove extremely challenging. Out of the 4,500 oracle bone characters excavated, only a third have been successfully identified. Therefore, leveraging the advantages of advanced AI technology to assist in the decipherment of OBI is a highly essential research topic. However, fully utilizing AI's capabilities in these matters is reliant on having a comprehensive and high-quality annotated OBI dataset at hand whereas most existing datasets are only annotated in just a single or a few dimensions, limiting the value of their potential application. For instance, the Oracle-MNIST dataset only offers 30k images classified into 10 categories. Therefore, this paper proposes an Oracle Bone Inscriptions Multi-modal Dataset(OBIMD), which includes annotation information for 10,077 pieces of oracle bones. Each piece has two modalities: pixel-level aligned rubbings and facsimiles. The dataset annotates the detection boxes, character categories, transcriptions, corresponding inscription groups, and reading sequences in the groups of each oracle bone character, providing a comprehensive and high-quality level of annotations. This dataset can be used for a variety of AI-related research tasks relevant to the field of OBI, such as OBI Character Detection and Recognition, Rubbing Denoising, Character Matching, Character Generation, Reading Sequence Prediction, Missing Characters Completion task and so on. We believe that the creation and publication of a dataset like this will help significantly advance the application of AI algorithms in the field of OBI research.

Mitigating hallucinations of Large Multi-modal Models(LMMs) is crucial to enhance their reliability for general-purpose assistants. This paper shows that such hallucinations of LMMs can be significantly exacerbated by preceding user-system dialogues. To precisely measure this, we first present an evaluation benchmark by extending popular multi-modal benchmark datasets with prepended hallucinatory dialogues generated by our novel Adversarial Question Generator, which can automatically generate image-related yet adversarial dialogues by adopting adversarial attacks on LMMs. On our benchmark, the zero-shot performance of state-of-the-art LMMs dropped significantly for both the VQA and Captioning tasks. Next, we further reveal this hallucination is mainly due to the prediction bias toward preceding dialogues rather than visual content. To reduce this bias, we propose Adversarial Instruction Tuning that robustly fine-tunes LMMs on augmented multi-modal instruction-following datasets with hallucinatory dialogues. Extensive experiments show that our proposed approach successfully reduces dialogue hallucination while maintaining or even improving performance.

The rapid advancement of autonomous systems, including self-driving vehicles and drones, has intensified the need to forge true Spatial Intelligence from multi-modal onboard sensor data. While foundation models excel in single-modal contexts, integrating their capabilities across diverse sensors like cameras and LiDAR to create a unified understanding remains a formidable challenge. This paper presents a comprehensive framework for multi-modal pre-training, identifying the core set of techniques driving progress toward this goal. We dissect the interplay between foundational sensor characteristics and learning strategies, evaluating the role of platform-specific datasets in enabling these advancements. Our central contribution is the formulation of a unified taxonomy for pre-training paradigms: ranging from single-modality baselines to sophisticated unified frameworks that learn holistic representations for advanced tasks like 3D object detection and semantic occupancy prediction. Furthermore, we investigate the integration of textual inputs and occupancy representations to facilitate open-world perception and planning. Finally, we identify critical bottlenecks, such as computational efficiency and model scalability, and propose a roadmap toward general-purpose multi-modal foundation models capable of achieving robust Spatial Intelligence for real-world deployment.

Vision-Language-Action (VLA) models aim to control robots for manipulation from visual observations and natural-language instructions. However, existing hierarchical and autoregressive paradigms often introduce architectural overhead, suffer from temporal inconsistency and long-horizon error accumulation, and lack a mechanism to capture environment dynamics without extra modules. To this end, we present MMaDA-VLA, a fully native pre-trained large diffusion VLA model that unifies multi-modal understanding and generation in a single framework. Our key idea is a native discrete diffusion formulation that embeds language, images, and continuous robot controls into one discrete token space and trains a single backbone with masked token denoising to jointly generate a future goal observation and an action chunk in parallel. Iterative denoising enables global, order-free refinement, improving long-horizon consistency while grounding actions in predicted future visual outcomes without auxiliary world models. Experiments across simulation benchmarks and real-world tasks show state-of-the-art performance, achieving 98.0% average success on LIBERO and 4.78 average length on CALVIN.

Large Language Models (LLMs) demonstrate remarkable generalizability across diverse tasks, yet genomic foundation models (GFMs) still require separate finetuning for each downstream application, creating significant overhead as model sizes grow. Moreover, existing GFMs are constrained by rigid output formats, limiting their applicability to various genomic tasks. In this work, we revisit the transformer-based auto-regressive models and introduce Omni-DNA, a family of cross-modal multi-task models ranging from 20 million to 1 billion parameters. Our approach consists of two stages: (i) pretraining on DNA sequences with next token prediction objective, and (ii) expanding the multi-modal task-specific tokens and finetuning for multiple downstream tasks simultaneously. When evaluated on the Nucleotide Transformer and GB benchmarks, Omni-DNA achieves state-of-the-art performance on 18 out of 26 tasks. Through multi-task finetuning, Omni-DNA addresses 10 acetylation and methylation tasks at once, surpassing models trained on each task individually. Finally, we design two complex genomic tasks, DNA2Function and Needle-in-DNA, which map DNA sequences to textual functional descriptions and images, respectively, indicating Omni-DNA's cross-modal capabilities to broaden the scope of genomic applications. All the models are available through https://huggingface.co/collections/zehui127

The integration of biomolecular modeling with natural language (BL) has emerged as a promising interdisciplinary area at the intersection of artificial intelligence, chemistry and biology. This approach leverages the rich, multifaceted descriptions of biomolecules contained within textual data sources to enhance our fundamental understanding and enable downstream computational tasks such as biomolecule property prediction. The fusion of the nuanced narratives expressed through natural language with the structural and functional specifics of biomolecules described via various molecular modeling techniques opens new avenues for comprehensively representing and analyzing biomolecules. By incorporating the contextual language data that surrounds biomolecules into their modeling, BL aims to capture a holistic view encompassing both the symbolic qualities conveyed through language as well as quantitative structural characteristics. In this review, we provide an extensive analysis of recent advancements achieved through cross modeling of biomolecules and natural language. (1) We begin by outlining the technical representations of biomolecules employed, including sequences, 2D graphs, and 3D structures. (2) We then examine in depth the rationale and key objectives underlying effective multi-modal integration of language and molecular data sources. (3) We subsequently survey the practical applications enabled to date in this developing research area. (4) We also compile and summarize the available resources and datasets to facilitate future work. (5) Looking ahead, we identify several promising research directions worthy of further exploration and investment to continue advancing the field. The related resources and contents are updating in https://github.com/QizhiPei/Awesome-Biomolecule-Language-Cross-Modeling.

The improved competence of generative models can help building multi-modal virtual assistants that leverage modalities beyond language. By observing humans performing multi-step tasks, one can build assistants that have situational awareness of actions and tasks being performed, enabling them to cater assistance based on this understanding. In this paper, we develop a Context-aware Instructional Task Assistant with Multi-modal Large Language Models (InsTALL) that leverages an online visual stream (e.g. a user's screen share or video recording) and responds in real-time to user queries related to the task at hand. To enable useful assistance, InsTALL 1) trains a multi-modal model on task videos and paired textual data, and 2) automatically extracts task graph from video data and leverages it at training and inference time. We show InsTALL achieves state-of-the-art performance across proposed sub-tasks considered for multimodal activity understanding -- task recognition (TR), action recognition (AR), next action prediction (AP), and plan prediction (PP) -- and outperforms existing baselines on two novel sub-tasks related to automatic error identification.

This paper introduces M^{3}-20M, a large-scale Multi-Modal Molecular dataset that contains over 20 million molecules. Designed to support AI-driven drug design and discovery, M^{3}-20M is 71 times more in the number of molecules than the largest existing dataset, providing an unprecedented scale that can highly benefit training or fine-tuning large (language) models with superior performance for drug design and discovery. This dataset integrates one-dimensional SMILES, two-dimensional molecular graphs, three-dimensional molecular structures, physicochemical properties, and textual descriptions collected through web crawling and generated by using GPT-3.5, offering a comprehensive view of each molecule. To demonstrate the power of M^{3}-20M in drug design and discovery, we conduct extensive experiments on two key tasks: molecule generation and molecular property prediction, using large language models including GLM4, GPT-3.5, and GPT-4. Our experimental results show that M^{3}-20M can significantly boost model performance in both tasks. Specifically, it enables the models to generate more diverse and valid molecular structures and achieve higher property prediction accuracy than the existing single-modal datasets, which validates the value and potential of M^{3}-20M in supporting AI-driven drug design and discovery. The dataset is available at https://github.com/bz99bz/M-3.

Visual layouts are essential in graphic design fields such as advertising, posters, and web interfaces. The application of generative models for content-aware layout generation has recently gained traction. However, these models fail to understand the contextual aesthetic requirements of layout design and do not align with human-like preferences, primarily treating it as a prediction task without considering the final rendered output. To overcome these problems, we offer Aesthetic-Aware Preference Alignment(AAPA), a novel technique to train a Multi-modal Large Language Model (MLLM) for layout prediction that uses MLLM's aesthetic preferences for Direct Preference Optimization over graphic layouts. We propose a data filtering protocol utilizing our layout-quality heuristics for AAPA to ensure training happens on high-quality layouts. Additionally, we introduce a novel evaluation metric that uses another MLLM to compute the win rate of the generated layout against the ground-truth layout based on aesthetics criteria. We also demonstrate the applicability of AAPA for MLLMs of varying scales (1B to 8B parameters) and LLM families (Qwen, Phi, InternLM). By conducting thorough qualitative and quantitative analyses, we verify the efficacy of our approach on two challenging benchmarks - Crello and Webui, showcasing 17%, and 16 improvement over current State-of-The-Art methods, thereby highlighting the potential of MLLMs in aesthetic-aware layout generation.

The computer vision domain has greatly benefited from an abundance of data across many modalities to improve on various visual tasks. Recently, there has been a lot of focus on self-supervised pre-training methods through Masked Autoencoders (MAE) he2022masked,bachmann2022multimae, usually used as a first step before optimizing for a downstream task, such as classification or regression. This is very useful as it doesn't require any manually labeled data. In this work, we introduce Probabilistic Hyper-Graphs using Masked Autoencoders (PHG-MAE): a novel model that unifies the classical work on neural graphs leordeanu2021semi with the modern approach of masked autoencoders under a common theoretical framework. Through random masking of entire modalities, not just patches, the model samples from the distribution of hyper-edges on each forward pass. Additionally, the model adapts the standard MAE algorithm by combining pre-training and fine-tuning into a single training loop. Moreover, our approach enables the creation of inference-time ensembles which, through aggregation, boost the final prediction performance and consistency. Lastly, we show that we can apply knowledge distillation on top of the ensembles with little loss in performance, even with models that have fewer than 1M parameters. While our work mostly focuses on outdoor UAV scenes that contain multiple world interpretations and modalities, the same steps can be followed in other similar domains, such as autonomous driving or indoor robotics. In order to streamline the process of integrating external pre-trained experts for computer vision multi-modal multi-task learning (MTL) scenarios, we developed a data-pipeline software. Using this tool, we have created and released a fully-automated extension of the Dronescapes dataset. All the technical details, code and reproduction steps are publicly released.

The prevalence of sarcasm in social media, conveyed through text-image combinations, presents significant challenges for sentiment analysis and intention mining. Current multi-modal sarcasm detection methods have been proven to struggle with biases from spurious cues, leading to a superficial understanding of the complex interactions between text and image. To address these issues, we propose InterCLIP-MEP, a robust framework for multi-modal sarcasm detection. InterCLIP-MEP introduces a refined variant of CLIP, Interactive CLIP (InterCLIP), as the backbone, enhancing sample representations by embedding cross-modality information in each encoder. Furthermore, a novel training strategy is designed to adapt InterCLIP for a Memory-Enhanced Predictor (MEP). MEP uses dynamic dual-channel memory to store valuable historical knowledge of test samples and then leverages this memory as a non-parametric classifier to derive the final prediction. By using InterCLIP to encode text-image interactions more effectively and incorporating MEP, InterCLIP-MEP offers a more robust recognition of multi-modal sarcasm. Experiments demonstrate that InterCLIP-MEP achieves state-of-the-art performance on the MMSD2.0 benchmark. Code and data are available at [https://github.com/CoderChen01/InterCLIP-MEP](https://github.com/CoderChen01/InterCLIP-MEP).

Cardiac biosignals, such as electrocardiograms (ECG) and photoplethysmograms (PPG), are of paramount importance for the diagnosis, prevention, and management of cardiovascular diseases, and have been extensively used in a variety of clinical tasks. Conventional deep learning approaches for analyzing these signals typically rely on homogeneous datasets and static bespoke models, limiting their robustness and generalizability across diverse clinical settings and acquisition protocols. In this study, we present a cardiac sensing foundation model (CSFM) that leverages advanced transformer architectures and a generative, masked pretraining strategy to learn unified representations from vast, heterogeneous health records. Our model is pretrained on an innovative multi-modal integration of data from multiple large-scale datasets (including MIMIC-III-WDB, MIMIC-IV-ECG, and CODE), comprising cardiac signals and the corresponding clinical or machine-generated text reports from approximately 1.7 million individuals. We demonstrate that the embeddings derived from our CSFM not only serve as effective feature extractors across diverse cardiac sensing scenarios, but also enable seamless transfer learning across varying input configurations and sensor modalities. Extensive evaluations across diagnostic tasks, demographic information recognition, vital sign measurement, clinical outcome prediction, and ECG question answering reveal that CSFM consistently outperforms traditional one-modal-one-task approaches. Notably, CSFM exhibits robust performance across multiple ECG lead configurations from standard 12-lead systems to single-lead setups, and in scenarios where only ECG, only PPG, or a combination thereof is available. These findings highlight the potential of CSFM as a versatile and scalable solution, for comprehensive cardiac monitoring.

While the integration of Multi-modal Large Language Models (MLLMs) with robotic systems has significantly improved robots' ability to understand and execute natural language instructions, their performance in manipulation tasks remains limited due to a lack of robotics-specific knowledge. Conventional MLLMs are typically trained on generic image-text pairs, leaving them deficient in understanding affordances and physical concepts crucial for manipulation. To address this gap, we propose ManipVQA, a novel framework that infuses MLLMs with manipulation-centric knowledge through a Visual Question-Answering (VQA) format. This approach encompasses tool detection, affordance recognition, and a broader understanding of physical concepts. We curated a diverse dataset of images depicting interactive objects, to challenge robotic understanding in tool detection, affordance prediction, and physical concept comprehension. To effectively integrate this robotics-specific knowledge with the inherent vision-reasoning capabilities of MLLMs, we leverage a unified VQA format and devise a fine-tuning strategy. This strategy preserves the original vision-reasoning abilities while incorporating the newly acquired robotic insights. Empirical evaluations conducted in robotic simulators and across various vision task benchmarks demonstrate the robust performance of ManipVQA. The code and dataset are publicly available at https://github.com/SiyuanHuang95/ManipVQA.

Accurate prognosis for an individual patient is a key component of precision oncology. Recent advances in machine learning have enabled the development of models using a wider range of data, including imaging. Radiomics aims to extract quantitative predictive and prognostic biomarkers from routine medical imaging, but evidence for computed tomography radiomics for prognosis remains inconclusive. We have conducted an institutional machine learning challenge to develop an accurate model for overall survival prediction in head and neck cancer using clinical data etxracted from electronic medical records and pre-treatment radiological images, as well as to evaluate the true added benefit of radiomics for head and neck cancer prognosis. Using a large, retrospective dataset of 2,552 patients and a rigorous evaluation framework, we compared 12 different submissions using imaging and clinical data, separately or in combination. The winning approach used non-linear, multitask learning on clinical data and tumour volume, achieving high prognostic accuracy for 2-year and lifetime survival prediction and outperforming models relying on clinical data only, engineered radiomics and deep learning. Combining all submissions in an ensemble model resulted in improved accuracy, with the highest gain from a image-based deep learning model. Our results show the potential of machine learning and simple, informative prognostic factors in combination with large datasets as a tool to guide personalized cancer care.

We cast real-world humanoid control as a next token prediction problem, akin to predicting the next word in language. Our model is a causal transformer trained via autoregressive prediction of sensorimotor trajectories. To account for the multi-modal nature of the data, we perform prediction in a modality-aligned way, and for each input token predict the next token from the same modality. This general formulation enables us to leverage data with missing modalities, like video trajectories without actions. We train our model on a collection of simulated trajectories coming from prior neural network policies, model-based controllers, motion capture data, and YouTube videos of humans. We show that our model enables a full-sized humanoid to walk in San Francisco zero-shot. Our model can transfer to the real world even when trained on only 27 hours of walking data, and can generalize to commands not seen during training like walking backward. These findings suggest a promising path toward learning challenging real-world control tasks by generative modeling of sensorimotor trajectories.

In this paper, we present StrucTexTv2, an effective document image pre-training framework, by performing masked visual-textual prediction. It consists of two self-supervised pre-training tasks: masked image modeling and masked language modeling, based on text region-level image masking. The proposed method randomly masks some image regions according to the bounding box coordinates of text words. The objectives of our pre-training tasks are reconstructing the pixels of masked image regions and the corresponding masked tokens simultaneously. Hence the pre-trained encoder can capture more textual semantics in comparison to the masked image modeling that usually predicts the masked image patches. Compared to the masked multi-modal modeling methods for document image understanding that rely on both the image and text modalities, StrucTexTv2 models image-only input and potentially deals with more application scenarios free from OCR pre-processing. Extensive experiments on mainstream benchmarks of document image understanding demonstrate the effectiveness of StrucTexTv2. It achieves competitive or even new state-of-the-art performance in various downstream tasks such as image classification, layout analysis, table structure recognition, document OCR, and information extraction under the end-to-end scenario.

Clinical trials are crucial for drug development but are time consuming, expensive, and often burdensome on patients. More importantly, clinical trials face uncertain outcomes due to issues with efficacy, safety, or problems with patient recruitment. If we were better at predicting the results of clinical trials, we could avoid having to run trials that will inevitably fail more resources could be devoted to trials that are likely to succeed. In this paper, we propose Hierarchical INteraction Network (HINT) for more general, clinical trial outcome predictions for all diseases based on a comprehensive and diverse set of web data including molecule information of the drugs, target disease information, trial protocol and biomedical knowledge. HINT first encode these multi-modal data into latent embeddings, where an imputation module is designed to handle missing data. Next, these embeddings will be fed into the knowledge embedding module to generate knowledge embeddings that are pretrained using external knowledge on pharmaco-kinetic properties and trial risk from the web. Then the interaction graph module will connect all the embedding via domain knowledge to fully capture various trial components and their complex relations as well as their influences on trial outcomes. Finally, HINT learns a dynamic attentive graph neural network to predict trial outcome. Comprehensive experimental results show that HINT achieves strong predictive performance, obtaining 0.772, 0.607, 0.623, 0.703 on PR-AUC for Phase I, II, III, and indication outcome prediction, respectively. It also consistently outperforms the best baseline method by up to 12.4\% on PR-AUC.

Predicting gene function from its DNA sequence is a fundamental challenge in biology. Many deep learning models have been proposed to embed DNA sequences and predict their enzymatic function, leveraging information in public databases linking DNA sequences to an enzymatic function label. However, much of the scientific community's knowledge of biological function is not represented in these categorical labels, and is instead captured in unstructured text descriptions of mechanisms, reactions, and enzyme behavior. These descriptions are often captured alongside DNA sequences in biological databases, albeit in an unstructured manner. Deep learning of models predicting enzymatic function are likely to benefit from incorporating this multi-modal data encoding scientific knowledge of biological function. There is, however, no dataset designed for machine learning algorithms to leverage this multi-modal information. Here we propose a novel dataset and benchmark suite that enables the exploration and development of large multi-modal neural network models on gene DNA sequences and natural language descriptions of gene function. We present baseline performance on benchmarks for both unsupervised and supervised tasks that demonstrate the difficulty of this modeling objective, while demonstrating the potential benefit of incorporating multi-modal data types in function prediction compared to DNA sequences alone. Our dataset is at: https://hoarfrost-lab.github.io/BioTalk/.

Although multi-modal large language models (MLLMs) have shown strong capabilities across diverse domains, their application in generating fine-grained 3D perception and prediction outputs in autonomous driving remains underexplored. In this paper, we propose DrivePI, a novel spatial-aware 4D MLLM that serves as a unified Vision-Language-Action (VLA) framework that is also compatible with vision-action (VA) models. Our method jointly performs spatial understanding, 3D perception (i.e., 3D occupancy), prediction (i.e., occupancy flow), and planning (i.e., action outputs) in parallel through end-to-end optimization. To obtain both precise geometric information and rich visual appearance, our approach integrates point clouds, multi-view images, and language instructions within a unified MLLM architecture. We further develop a data engine to generate text-occupancy and text-flow QA pairs for 4D spatial understanding. Remarkably, with only a 0.5B Qwen2.5 model as MLLM backbone, DrivePI as a single unified model matches or exceeds both existing VLA models and specialized VA models. Specifically, compared to VLA models, DrivePI outperforms OpenDriveVLA-7B by 2.5% mean accuracy on nuScenes-QA and reduces collision rate by 70% over ORION (from 0.37% to 0.11%) on nuScenes. Against specialized VA models, DrivePI surpasses FB-OCC by 10.3 RayIoU for 3D occupancy on OpenOcc, reduces the mAVE from 0.591 to 0.509 for occupancy flow on OpenOcc, and achieves 32% lower L2 error than VAD (from 0.72m to 0.49m) for planning on nuScenes. Code will be available at https://github.com/happinesslz/DrivePI

Pre-trained large language models (LLMs) are commonly fine-tuned to adapt to downstream tasks. Since the majority of knowledge is acquired during pre-training, attributing the predictions of fine-tuned LLMs to their pre-training data may provide valuable insights. Influence functions have been proposed as a means to explain model predictions based on training data. However, existing approaches fail to compute ``multi-stage'' influence and lack scalability to billion-scale LLMs. In this paper, we propose the multi-stage influence function to attribute the downstream predictions of fine-tuned LLMs to pre-training data under the full-parameter fine-tuning paradigm. To enhance the efficiency and practicality of our multi-stage influence function, we leverage Eigenvalue-corrected Kronecker-Factored (EK-FAC) parameterization for efficient approximation. Empirical results validate the superior scalability of EK-FAC approximation and the effectiveness of our multi-stage influence function. Additionally, case studies on a real-world LLM, dolly-v2-3b, demonstrate its interpretive power, with exemplars illustrating insights provided by multi-stage influence estimates. Our code is public at https://github.com/colored-dye/multi_stage_influence_function.

Large Language Models (LLMs) have demonstrated impressive performance across various tasks, with different models excelling in distinct domains and specific abilities. Effectively combining the predictions of multiple LLMs is crucial for enhancing system robustness and performance. However, existing ensemble methods often rely on simple techniques like voting or logits ensembling, which overlook the varying confidence and reliability of models in different contexts. In this work, we propose LENS (Learning ENsemble confidence from Neural States), a novel approach that learns to estimate model confidence by analyzing internal representations. For each LLM, we train a lightweight linear confidence predictor that leverages layer-wise hidden states and normalized probabilities as inputs. This allows for more nuanced weighting of model predictions based on their context-dependent reliability. Our method does not require modifying the model parameters and requires negligible additional computation. Experimental results on multiple-choice and boolean question-answering tasks demonstrate that LENS outperforms traditional ensemble methods by a substantial margin. Our findings suggest that internal representations provide valuable signals for determining model confidence and can be effectively leveraged for ensemble learning.

Understanding biological processes, drug development, and biotechnological advancements requires detailed analysis of protein structures and sequences, a task in protein research that is inherently complex and time-consuming when performed manually. To streamline this process, we introduce ProteinGPT, a state-of-the-art multi-modal protein chat system, that allows users to upload protein sequences and/or structures for comprehensive protein analysis and responsive inquiries. ProteinGPT seamlessly integrates protein sequence and structure encoders with linear projection layers for precise representation adaptation, coupled with a large language model (LLM) to generate accurate and contextually relevant responses. To train ProteinGPT, we construct a large-scale dataset of 132,092 proteins with annotations, and optimize the instruction-tuning process using GPT-4o. This innovative system ensures accurate alignment between the user-uploaded data and prompts, simplifying protein analysis. Experiments show that ProteinGPT can produce promising responses to proteins and their corresponding questions.

Multi-sensor fusion is crucial for improving the performance and robustness of end-to-end autonomous driving systems. Existing methods predominantly adopt either attention-based flatten fusion or bird's eye view fusion through geometric transformations. However, these approaches often suffer from limited interpretability or dense computational overhead. In this paper, we introduce GaussianFusion, a Gaussian-based multi-sensor fusion framework for end-to-end autonomous driving. Our method employs intuitive and compact Gaussian representations as intermediate carriers to aggregate information from diverse sensors. Specifically, we initialize a set of 2D Gaussians uniformly across the driving scene, where each Gaussian is parameterized by physical attributes and equipped with explicit and implicit features. These Gaussians are progressively refined by integrating multi-modal features. The explicit features capture rich semantic and spatial information about the traffic scene, while the implicit features provide complementary cues beneficial for trajectory planning. To fully exploit rich spatial and semantic information in Gaussians, we design a cascade planning head that iteratively refines trajectory predictions through interactions with Gaussians. Extensive experiments on the NAVSIM and Bench2Drive benchmarks demonstrate the effectiveness and robustness of the proposed GaussianFusion framework. The source code will be released at https://github.com/Say2L/GaussianFusion.

The aim of this study is to develop surrogate models for quick, accurate prediction of thrust forces generated through flapping fin propulsion for given operating conditions and fin geometries. Different network architectures and configurations are explored to model the training data separately for the lead fin and rear fin of a tandem fin setup. We progressively improve the data representation of the input parameter space for model predictions. The models are tested on three unseen fin geometries and the predictions validated with computational fluid dynamics (CFD) data. Finally, the orders of magnitude gains in computational performance of these surrogate models, compared to experimental and CFD runs, vs their tradeoff with accuracy is discussed within the context of this tandem fin configuration.

Multi-view learning (MVL) leverages multiple sources or views of data to enhance machine learning model performance and robustness. This approach has been successfully used in the Earth Observation (EO) domain, where views have a heterogeneous nature and can be affected by missing data. Despite the negative effect that missing data has on model predictions, the ML literature has used it as an augmentation technique to improve model generalization, like masking the input data. Inspired by this, we introduce novel methods for EO applications tailored to MVL with missing views. Our methods integrate the combination of a set to simulate all combinations of missing views as different training samples. Instead of replacing missing data with a numerical value, we use dynamic merge functions, like average, and more complex ones like Transformer. This allows the MVL model to entirely ignore the missing views, enhancing its predictive robustness. We experiment on four EO datasets with temporal and static views, including state-of-the-art methods from the EO domain. The results indicate that our methods improve model robustness under conditions of moderate missingness, and improve the predictive performance when all views are present. The proposed methods offer a single adaptive solution to operate effectively with any combination of available views.

The task of 3D semantic scene graph (3DSSG) prediction in the point cloud is challenging since (1) the 3D point cloud only captures geometric structures with limited semantics compared to 2D images, and (2) long-tailed relation distribution inherently hinders the learning of unbiased prediction. Since 2D images provide rich semantics and scene graphs are in nature coped with languages, in this study, we propose Visual-Linguistic Semantics Assisted Training (VL-SAT) scheme that can significantly empower 3DSSG prediction models with discrimination about long-tailed and ambiguous semantic relations. The key idea is to train a powerful multi-modal oracle model to assist the 3D model. This oracle learns reliable structural representations based on semantics from vision, language, and 3D geometry, and its benefits can be heterogeneously passed to the 3D model during the training stage. By effectively utilizing visual-linguistic semantics in training, our VL-SAT can significantly boost common 3DSSG prediction models, such as SGFN and SGGpoint, only with 3D inputs in the inference stage, especially when dealing with tail relation triplets. Comprehensive evaluations and ablation studies on the 3DSSG dataset have validated the effectiveness of the proposed scheme. Code is available at https://github.com/wz7in/CVPR2023-VLSAT.

In this work, we introduce Wallaroo, a simple autoregressive baseline that leverages next-token prediction to unify multi-modal understanding, image generation, and editing at the same time. Moreover, Wallaroo supports multi-resolution image input and output, as well as bilingual support for both Chinese and English. We decouple the visual encoding into separate pathways and apply a four-stage training strategy to reshape the model's capabilities. Experiments are conducted on various benchmarks where Wallaroo produces competitive performance or exceeds other unified models, suggesting the great potential of autoregressive models in unifying multi-modality understanding and generation. Our code is available at https://github.com/JiePKU/Wallaroo.

Alzheimer's Disease (AD) is marked by significant inter-individual variability in its progression, complicating accurate prognosis and personalized care planning. This heterogeneity underscores the critical need for predictive models capable of forecasting patient-specific disease trajectories. Artificial Intelligence (AI) offers powerful tools to address this challenge by analyzing complex, multi-modal, and longitudinal patient data. This paper provides a comprehensive survey of AI methodologies applied to personalized AD progression prediction. We review key approaches including state-space models for capturing temporal dynamics, deep learning techniques like Recurrent Neural Networks for sequence modeling, Graph Neural Networks (GNNs) for leveraging network structures, and the emerging concept of AI-driven digital twins for individualized simulation. Recognizing that data limitations often impede progress, we examine common challenges such as high dimensionality, missing data, and dataset imbalance. We further discuss AI-driven mitigation strategies, with a specific focus on synthetic data generation using Variational Autoencoders (VAEs) and Generative Adversarial Networks (GANs) to augment and balance datasets. The survey synthesizes the strengths and limitations of current approaches, emphasizing the trend towards multimodal integration and the persistent need for model interpretability and generalizability. Finally, we identify critical open challenges, including robust external validation, clinical integration, and ethical considerations, and outline promising future research directions such as hybrid models, causal inference, and federated learning. This review aims to consolidate current knowledge and guide future efforts in developing clinically relevant AI tools for personalized AD prognostication.

Social media popularity prediction task aims to predict the popularity of posts on social media platforms, which has a positive driving effect on application scenarios such as content optimization, digital marketing and online advertising. Though many studies have made significant progress, few of them pay much attention to the integration between popularity prediction with temporal alignment. In this paper, with exploring YouTube's multilingual and multi-modal content, we construct a new social media temporal popularity prediction benchmark, namely SMTPD, and suggest a baseline framework for temporal popularity prediction. Through data analysis and experiments, we verify that temporal alignment and early popularity play crucial roles in social media popularity prediction for not only deepening the understanding of temporal dynamics of popularity in social media but also offering a suggestion about developing more effective prediction models in this field. Code is available at https://github.com/zhuwei321/SMTPD.

Stars on the AGB can exhibit acoustic pulsation modes of different radial orders, along with non-radial modes. These pulsations are essential to the mass-loss process and influence the evolutionary pathways of AGB stars. P-L relations serve as a valuable diagnostic for understanding stellar evolution along the AGB. 3D RHD simulations provide a powerful tool for investigating pulsation phenomena driven by convective processes and their non-linear coupling with stellar oscillations. We investigate multi-mode pulsations in AGB stars using advanced 3D 'star-in-a-box' simulations with the CO5BOLD code. Signatures of these multi-mode pulsations were weak in our previous 3D models. Our focus is on identifying and characterising the various pulsation modes, examining their persistence and transitions, and comparing the results with 1D model predictions and observational data where applicable. We produced a new model grid comprising AGB stars with current masses of 0.7, 0.8, and 1,M_{odot}. Fourier analysis was applied to dynamic, time-dependent quantities to extract dominant pulsation modes and their corresponding periods. Additionally, wavelet transforms were employed to identify mode-switching behaviour over time. The models successfully reproduce the P-L sequences found in AGB stars. Mode-switching phenomena are found in both the models and wavelet analyses of observational data, allowing us to infer similarities in the underlying pulsation dynamics. These 3D simulations highlight the natural emergence of multi-mode pulsations, including both radial and non-radial modes, driven by the self-consistent interplay of convection and oscillations. Our findings underscore the value of 3D RHD models in capturing the non-linear behaviour of AGB pulsations, providing insights into mode switching, envelope structures, and potential links to episodic mass-loss events.

Recent advancements in Vision-Language-Action (VLA) models have leveraged pre-trained Vision-Language Models (VLMs) to improve the generalization capabilities. VLMs, typically pre-trained on vision-language understanding tasks, provide rich semantic knowledge and reasoning abilities. However, prior research has shown that VLMs often focus on high-level semantic content and neglect low-level features, limiting their ability to capture detailed spatial information and understand physical dynamics. These aspects, which are crucial for embodied control tasks, remain underexplored in existing pre-training paradigms. In this paper, we investigate the training paradigm for VLAs, and introduce UP-VLA, a Unified VLA model training with both multi-modal Understanding and future Prediction objectives, enhancing both high-level semantic comprehension and low-level spatial understanding. Experimental results show that UP-VLA achieves a 33% improvement on the Calvin ABC-D benchmark compared to the previous state-of-the-art method. Additionally, UP-VLA demonstrates improved success rates in real-world manipulation tasks, particularly those requiring precise spatial information.

The difficulty of monitoring biodiversity at fine scales and over large areas limits ecological knowledge and conservation efforts. To fill this gap, Species Distribution Models (SDMs) predict species across space from spatially explicit features. Yet, they face the challenge of integrating the rich but heterogeneous data made available over the past decade, notably millions of opportunistic species observations and standardized surveys, as well as multi-modal remote sensing data. In light of that, we have designed and developed a new European-scale dataset for SDMs at high spatial resolution (10-50 m), including more than 10k species (i.e., most of the European flora). The dataset comprises 5M heterogeneous Presence-Only records and 90k exhaustive Presence-Absence survey records, all accompanied by diverse environmental rasters (e.g., elevation, human footprint, and soil) that are traditionally used in SDMs. In addition, it provides Sentinel-2 RGB and NIR satellite images with 10 m resolution, a 20-year time-series of climatic variables, and satellite time-series from the Landsat program. In addition to the data, we provide an openly accessible SDM benchmark (hosted on Kaggle), which has already attracted an active community and a set of strong baselines for single predictor/modality and multimodal approaches. All resources, e.g., the dataset, pre-trained models, and baseline methods (in the form of notebooks), are available on Kaggle, allowing one to start with our dataset literally with two mouse clicks.

Knowledge graphs are incomplete by nature, with only a limited number of observed facts from the world knowledge being represented as structured relations between entities. To partly address this issue, an important task in statistical relational learning is that of link prediction or knowledge graph completion. Both linear and non-linear models have been proposed to solve the problem. Bilinear models, while expressive, are prone to overfitting and lead to quadratic growth of parameters in number of relations. Simpler models have become more standard, with certain constraints on bilinear map as relation parameters. In this work, we propose a factorized bilinear pooling model, commonly used in multi-modal learning, for better fusion of entities and relations, leading to an efficient and constraint-free model. We prove that our model is fully expressive, providing bounds on the embedding dimensionality and factorization rank. Our model naturally generalizes Tucker decomposition based TuckER model, which has been shown to generalize other models, as efficient low-rank approximation without substantially compromising the performance. Due to low-rank approximation, the model complexity can be controlled by the factorization rank, avoiding the possible cubic growth of TuckER. Empirically, we evaluate on real-world datasets, reaching on par or state-of-the-art performance. At extreme low-ranks, model preserves the performance while staying parameter efficient.

Uncertainty estimation is a significant issue for current large language models (LLMs) that are generally poorly calibrated and over-confident, especially with reinforcement learning from human feedback (RLHF). Unlike humans, whose decisions and confidences not only stem from intrinsic beliefs but can also be adjusted through daily observations, existing calibration methods for LLMs focus on estimating or eliciting individual confidence without taking full advantage of the "Collective Wisdom": the interaction among multiple LLMs that can collectively improve both accuracy and calibration. In this work, we propose Collaborative Calibration, a post-hoc training-free calibration strategy that leverages the collaborative and expressive capabilities of multiple tool-augmented LLM agents in a simulated group deliberation process. We demonstrate the effectiveness of Collaborative Calibration on generative QA tasks across various domains, showing its potential in harnessing the rationalization of collectively calibrated confidence assessments and improving the reliability of model predictions.

Despite remarkable progress in driving world models, their potential for autonomous systems remains largely untapped: the world models are mostly learned for world simulation and decoupled from trajectory planning. While recent efforts aim to unify world modeling and planning in a single framework, the synergistic facilitation mechanism of world modeling for planning still requires further exploration. In this work, we introduce a new driving paradigm named Policy World Model (PWM), which not only integrates world modeling and trajectory planning within a unified architecture, but is also able to benefit planning using the learned world knowledge through the proposed action-free future state forecasting scheme. Through collaborative state-action prediction, PWM can mimic the human-like anticipatory perception, yielding more reliable planning performance. To facilitate the efficiency of video forecasting, we further introduce a dynamically enhanced parallel token generation mechanism, equipped with a context-guided tokenizer and an adaptive dynamic focal loss. Despite utilizing only front camera input, our method matches or exceeds state-of-the-art approaches that rely on multi-view and multi-modal inputs. Code and model weights will be released at https://github.com/6550Zhao/Policy-World-Model.

Disease risk prediction has attracted increasing attention in the field of modern healthcare, especially with the latest advances in artificial intelligence (AI). Electronic health records (EHRs), which contain heterogeneous patient information, are widely used in disease risk prediction tasks. One challenge of applying AI models for risk prediction lies in generating interpretable evidence to support the prediction results while retaining the prediction ability. In order to address this problem, we propose the method of jointly embedding words and labels whereby attention modules learn the weights of words from medical notes according to their relevance to the names of risk prediction labels. This approach boosts interpretability by employing an attention mechanism and including the names of prediction tasks in the model. However, its application is only limited to the handling of textual inputs such as medical notes. In this paper, we propose a label dependent attention model LDAM to 1) improve the interpretability by exploiting Clinical-BERT (a biomedical language model pre-trained on a large clinical corpus) to encode biomedically meaningful features and labels jointly; 2) extend the idea of joint embedding to the processing of time-series data, and develop a multi-modal learning framework for integrating heterogeneous information from medical notes and time-series health status indicators. To demonstrate our method, we apply LDAM to the MIMIC-III dataset to predict different disease risks. We evaluate our method both quantitatively and qualitatively. Specifically, the predictive power of LDAM will be shown, and case studies will be carried out to illustrate its interpretability.

Breast cancer is one of the leading causes of death across the world in women. Early diagnosis of this type of cancer is critical for treatment and patient care. Computer-aided detection (CAD) systems using convolutional neural networks (CNN) could assist in the classification of abnormalities. In this study, we proposed an ensemble deep learning-based approach for automatic binary classification of breast histology images. The proposed ensemble model adapts three pre-trained CNNs, namely VGG19, MobileNet, and DenseNet. The ensemble model is used for the feature representation and extraction steps. The extracted features are then fed into a multi-layer perceptron classifier to carry out the classification task. Various pre-processing and CNN tuning techniques such as stain-normalization, data augmentation, hyperparameter tuning, and fine-tuning are used to train the model. The proposed method is validated on four publicly available benchmark datasets, i.e., ICIAR, BreakHis, PatchCamelyon, and Bioimaging. The proposed multi-model ensemble method obtains better predictions than single classifiers and machine learning algorithms with accuracies of 98.13%, 95.00%, 94.64% and 83.10% for BreakHis, ICIAR, PatchCamelyon and Bioimaging datasets, respectively.

In this era of technological advancements, several cutting-edge techniques are being implemented to enhance Autonomous Driving (AD) systems, focusing on improving safety, efficiency, and adaptability in complex driving environments. However, AD still faces some problems including performance limitations. To address this problem, we conducted an in-depth study on implementing the Multi-modal Large Language Model. We constructed a Virtual Question Answering (VQA) dataset to fine-tune the model and address problems with the poor performance of MLLM on AD. We then break down the AD decision-making process by scene understanding, prediction, and decision-making. Chain of Thought has been used to make the decision more perfectly. Our experiments and detailed analysis of Autonomous Driving give an idea of how important MLLM is for AD.

Physical AI aims to develop models that can perceive and predict real-world dynamics; yet, the extent to which current multi-modal large language models and video generative models support these abilities is insufficiently understood. We introduce Physical AI Bench (PAI-Bench), a unified and comprehensive benchmark that evaluates perception and prediction capabilities across video generation, conditional video generation, and video understanding, comprising 2,808 real-world cases with task-aligned metrics designed to capture physical plausibility and domain-specific reasoning. Our study provides a systematic assessment of recent models and shows that video generative models, despite strong visual fidelity, often struggle to maintain physically coherent dynamics, while multi-modal large language models exhibit limited performance in forecasting and causal interpretation. These observations suggest that current systems are still at an early stage in handling the perceptual and predictive demands of Physical AI. In summary, PAI-Bench establishes a realistic foundation for evaluating Physical AI and highlights key gaps that future systems must address.

A wide body of evidence shows that human language processing difficulty is predicted by the information-theoretic measure surprisal, a word's negative log probability in context. However, it is still unclear how to best estimate these probabilities needed for predicting human processing difficulty -- while a long-standing belief held that models with lower perplexity would provide more accurate estimates of word predictability, and therefore lead to better reading time predictions, recent work has shown that for very large models, psycholinguistic predictive power decreases. One reason could be that language models might be more confident of their predictions than humans, because they have had exposure to several magnitudes more data. In this paper, we test what effect temperature-scaling of large language model (LLM) predictions has on surprisal estimates and their predictive power of reading times of English texts. Firstly, we show that calibration of large language models typically improves with model size, i.e. poorer calibration cannot account for poorer fit to reading times. Secondly, we find that temperature-scaling probabilities lead to a systematically better fit to reading times (up to 89% improvement in delta log likelihood), across several reading time corpora. Finally, we show that this improvement in fit is chiefly driven by words that are composed of multiple subword tokens.

Current AI-assisted protein design mainly utilizes protein sequential and structural information. Meanwhile, there exists tremendous knowledge curated by humans in the text format describing proteins' high-level properties. Yet, whether the incorporation of such text data can help protein design tasks has not been explored. To bridge this gap, we propose ProteinDT, a multi-modal framework that leverages textual descriptions for protein design. ProteinDT consists of three subsequent steps: ProteinCLAP that aligns the representation of two modalities, a facilitator that generates the protein representation from the text modality, and a decoder that generates the protein sequences from the representation. To train ProteinDT, we construct a large dataset, SwissProtCLAP, with 441K text and protein pairs. We empirically verify the effectiveness of ProteinDT from three aspects: (1) consistently superior performance on four out of six protein property prediction benchmarks; (2) over 90% accuracy for text-guided protein generation; and (3) promising results for zero-shot text-guided protein editing.