sample_id,ancestry,PGx_CYP2D6_class,PGx_CYP2D6_CPIC,PGx_CYP2D6_ACMG_actionable,PGx_CYP2D6_recommendation,PGx_CYP2C19_class,PGx_CYP2C19_CPIC,PGx_CYP2C19_ACMG_actionable,PGx_CYP2C19_recommendation,PGx_CYP2C9_class,PGx_CYP2C9_CPIC,PGx_CYP2C9_ACMG_actionable,PGx_CYP2C9_recommendation,PGx_CYP3A5_class,PGx_CYP3A5_CPIC,PGx_CYP3A5_ACMG_actionable,PGx_CYP3A5_recommendation,PGx_TPMT_class,PGx_TPMT_CPIC,PGx_TPMT_ACMG_actionable,PGx_TPMT_recommendation,PGx_DPYD_class,PGx_DPYD_CPIC,PGx_DPYD_ACMG_actionable,PGx_DPYD_recommendation,PGx_UGT1A1_class,PGx_UGT1A1_CPIC,PGx_UGT1A1_ACMG_actionable,PGx_UGT1A1_recommendation,PGx_SLCO1B1_class,PGx_SLCO1B1_CPIC,PGx_SLCO1B1_ACMG_actionable,PGx_SLCO1B1_recommendation,PGx_G6PD_class,PGx_G6PD_CPIC,PGx_G6PD_ACMG_actionable,PGx_G6PD_recommendation,PGx_VKORC1_class,PGx_VKORC1_CPIC,PGx_VKORC1_ACMG_actionable,PGx_VKORC1_recommendation,PGx_HLA_B5701_class,PGx_HLA_B5701_CPIC,PGx_HLA_B5701_ACMG_actionable,PGx_HLA_B5701_recommendation,PGx_HLA_A3101_class,PGx_HLA_A3101_CPIC,PGx_HLA_A3101_ACMG_actionable,PGx_HLA_A3101_recommendation,PGx_CFTR_class,PGx_CFTR_CPIC,PGx_CFTR_ACMG_actionable,PGx_CFTR_recommendation,PGx_BRCA1_class,PGx_BRCA1_CPIC,PGx_BRCA1_ACMG_actionable,PGx_BRCA1_recommendation,PGx_BRCA2_class,PGx_BRCA2_CPIC,PGx_BRCA2_ACMG_actionable,PGx_BRCA2_recommendation,PGx_MLH1_class,PGx_MLH1_CPIC,PGx_MLH1_ACMG_actionable,PGx_MLH1_recommendation,PGx_MSH2_class,PGx_MSH2_CPIC,PGx_MSH2_ACMG_actionable,PGx_MSH2_recommendation,PGx_PALB2_class,PGx_PALB2_CPIC,PGx_PALB2_ACMG_actionable,PGx_PALB2_recommendation,PGx_CHEK2_class,PGx_CHEK2_CPIC,PGx_CHEK2_ACMG_actionable,PGx_CHEK2_recommendation,PGx_ATM_class,PGx_ATM_CPIC,PGx_ATM_ACMG_actionable,PGx_ATM_recommendation,PGx_NBN_class,PGx_NBN_CPIC,PGx_NBN_ACMG_actionable,PGx_NBN_recommendation,PGx_RAD51C_class,PGx_RAD51C_CPIC,PGx_RAD51C_ACMG_actionable,PGx_RAD51C_recommendation,PGx_RET_class,PGx_RET_CPIC,PGx_RET_ACMG_actionable,PGx_RET_recommendation,PGx_APC_class,PGx_APC_CPIC,PGx_APC_ACMG_actionable,PGx_APC_recommendation,PGx_MUTYH_class,PGx_MUTYH_CPIC,PGx_MUTYH_ACMG_actionable,PGx_MUTYH_recommendation
HLT013_000001,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000002,AFR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000003,AMR,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000004,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000005,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000006,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000007,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000008,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000009,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000010,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000011,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000012,SAS,UM,A,False,Consider alternative drug or higher dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000013,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000014,AMR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000015,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000016,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000017,AFR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000018,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000019,AMR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000020,EAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000021,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000022,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000023,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000024,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000025,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000026,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000027,AFR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000028,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000029,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000030,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000031,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000032,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000033,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000034,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000035,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000036,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000037,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000038,AFR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000039,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000040,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000041,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000042,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000043,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000044,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000045,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000046,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
HLT013_000047,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000048,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000049,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000050,EUR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000051,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000052,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000053,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000054,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000055,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000056,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
HLT013_000057,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000058,AFR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000059,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000060,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000061,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000062,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000063,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000064,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000065,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000066,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000067,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000068,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000069,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000070,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000071,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000072,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000073,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
HLT013_000074,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000075,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000076,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000077,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000078,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000079,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000080,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000081,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000082,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000083,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000084,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000085,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000086,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000087,EAS,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000088,AFR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000089,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000090,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000091,EUR,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000092,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000093,AFR,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000094,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000095,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000096,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
HLT013_000097,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000098,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000099,EUR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000100,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000101,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000102,EAS,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000103,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000104,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000105,EAS,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000106,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000107,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000108,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000109,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000110,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000111,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000112,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000113,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000114,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000115,EUR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000116,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000117,EAS,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000118,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000119,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000120,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000121,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000122,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000123,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000124,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000125,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000126,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000127,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000128,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000129,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000130,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000131,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000132,SAS,UM,A,False,Consider alternative drug or higher dose,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000133,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000134,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000135,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000136,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000137,SAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000138,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000139,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000140,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000141,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000142,AFR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000143,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000144,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000145,AFR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000146,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000147,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000148,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000149,AFR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000150,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000151,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000152,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000153,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000154,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000155,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000156,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000157,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000158,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000159,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000160,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000161,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000162,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000163,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000164,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000165,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000166,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000167,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000168,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000169,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000170,SAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000171,EUR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000172,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000173,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000174,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000175,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000176,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000177,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000178,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000179,AMR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000180,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000181,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000182,AMR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000183,AFR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000184,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000185,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000186,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000187,EUR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000188,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000189,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000190,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000191,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000192,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000193,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000194,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000195,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000196,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000197,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000198,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000199,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000200,EUR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000201,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000202,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000203,AFR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000204,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000205,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000206,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000207,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000208,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000209,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000210,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000211,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000212,AFR,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000213,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000214,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000215,EAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000216,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000217,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000218,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000219,SAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000220,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000221,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000222,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000223,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000224,SAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000225,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000226,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000227,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000228,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000229,EAS,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000230,EUR,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000231,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000232,AFR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000233,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000234,AFR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000235,SAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000236,AMR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000237,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000238,EAS,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000239,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000240,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000241,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000242,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,VUS,B,False,Variant of uncertain significance -- monitoring advised,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000243,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000244,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000245,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000246,AMR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
HLT013_000247,EAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000248,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000249,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000250,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000251,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000252,AMR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000253,AFR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000254,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000255,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000256,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000257,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000258,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000259,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000260,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000261,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000262,AMR,UM,A,False,Consider alternative drug or higher dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000263,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000264,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000265,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000266,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000267,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000268,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000269,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000270,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000271,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000272,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000273,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000274,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000275,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000276,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000277,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000278,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000279,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000280,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000281,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000282,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000283,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000284,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000285,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000286,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000287,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000288,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000289,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000290,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000291,AMR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000292,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000293,SAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000294,EUR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000295,AMR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000296,AMR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000297,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000298,AMR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000299,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000300,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000301,EAS,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000302,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000303,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000304,AFR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000305,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000306,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000307,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000308,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000309,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000310,EUR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000311,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000312,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000313,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000314,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000315,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000316,EUR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000317,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000318,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000319,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000320,SAS,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000321,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000322,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000323,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000324,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000325,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000326,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000327,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000328,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000329,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000330,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000331,EAS,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000332,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000333,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000334,AMR,UM,A,False,Consider alternative drug or higher dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000335,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000336,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000337,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000338,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000339,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000340,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000341,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000342,SAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000343,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000344,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000345,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000346,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000347,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000348,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000349,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000350,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000351,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000352,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000353,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000354,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000355,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000356,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000357,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000358,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000359,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000360,AFR,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000361,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000362,EUR,UM,A,False,Consider alternative drug or higher dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000363,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,biallelic_path,B,False,Increased colorectal cancer risk -- surveillance colonoscopy
HLT013_000364,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000365,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000366,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000367,EAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000368,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000369,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000370,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000371,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000372,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000373,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000374,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000375,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000376,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000377,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000378,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000379,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000380,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000381,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000382,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000383,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000384,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000385,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000386,SAS,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000387,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000388,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000389,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000390,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000391,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000392,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000393,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000394,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000395,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000396,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000397,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000398,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000399,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000400,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000401,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000402,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000403,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000404,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000405,SAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000406,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000407,EUR,UM,A,False,Consider alternative drug or higher dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000408,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000409,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000410,SAS,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000411,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000412,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000413,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000414,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000415,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000416,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000417,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000418,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000419,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000420,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000421,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000422,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000423,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000424,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000425,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000426,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000427,EUR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000428,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000429,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000430,AMR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
HLT013_000431,SAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000432,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000433,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000434,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000435,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000436,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000437,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000438,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000439,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000440,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000441,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000442,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000443,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000444,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000445,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000446,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000447,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000448,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000449,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000450,EAS,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000451,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000452,AMR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000453,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000454,EUR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000455,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000456,EUR,PM,A,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000457,SAS,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000458,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000459,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000460,EAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000461,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000462,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000463,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000464,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000465,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000466,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000467,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000468,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000469,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000470,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000471,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000472,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000473,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000474,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000475,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000476,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000477,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000478,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000479,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000480,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000481,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000482,EUR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000483,AFR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000484,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000485,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000486,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000487,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000488,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000489,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000490,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,VUS,B,False,Variant of uncertain significance -- monitoring advised,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000491,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000492,EAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000493,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000494,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000495,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000496,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000497,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000498,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000499,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000500,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000501,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000502,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000503,SAS,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000504,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000505,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000506,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000507,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000508,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000509,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000510,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000511,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000512,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000513,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000514,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000515,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000516,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000517,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000518,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000519,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000520,AMR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000521,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
HLT013_000522,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000523,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000524,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
HLT013_000525,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000526,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000527,SAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000528,SAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000529,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000530,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000531,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000532,EAS,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000533,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000534,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000535,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000536,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000537,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000538,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000539,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000540,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000541,SAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000542,AFR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000543,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000544,SAS,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000545,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000546,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000547,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000548,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000549,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000550,AFR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000551,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000552,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000553,EUR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000554,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000555,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000556,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000557,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000558,AFR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000559,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000560,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000561,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000562,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000563,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000564,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000565,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000566,EAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000567,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000568,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000569,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000570,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000571,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000572,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000573,AFR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000574,EAS,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000575,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000576,AFR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000577,AMR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000578,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000579,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000580,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000581,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000582,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000583,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000584,EUR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000585,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000586,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000587,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000588,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000589,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000590,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000591,SAS,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000592,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000593,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000594,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000595,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000596,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000597,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000598,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000599,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000600,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000601,AFR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000602,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000603,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000604,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000605,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000606,EAS,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000607,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000608,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000609,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000610,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000611,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000612,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000613,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000614,SAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000615,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000616,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000617,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000618,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000619,EUR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000620,EUR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000621,EAS,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000622,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000623,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000624,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000625,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000626,AFR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000627,EAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000628,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000629,AFR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000630,AMR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000631,SAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000632,AMR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000633,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000634,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000635,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000636,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000637,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000638,EAS,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000639,EAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000640,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000641,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000642,AMR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000643,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000644,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000645,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000646,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000647,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000648,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000649,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000650,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000651,AFR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000652,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000653,EAS,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000654,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000655,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000656,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000657,AMR,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000658,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000659,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000660,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000661,EUR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000662,AMR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000663,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000664,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000665,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000666,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000667,AMR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000668,SAS,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000669,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000670,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000671,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000672,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000673,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000674,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000675,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000676,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000677,AMR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000678,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000679,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000680,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000681,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000682,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000683,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000684,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000685,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000686,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000687,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000688,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000689,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000690,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000691,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000692,AMR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000693,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000694,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000695,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000696,AFR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000697,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000698,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,PM,A,False,Consider alternative therapy or reduce dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000699,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000700,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000701,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000702,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000703,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000704,AMR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000705,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000706,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000707,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000708,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000709,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000710,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000711,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000712,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000713,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000714,AMR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000715,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000716,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000717,AFR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000718,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000719,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000720,SAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000721,AFR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000722,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000723,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000724,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000725,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000726,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000727,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000728,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000729,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000730,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000731,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000732,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000733,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000734,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000735,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000736,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000737,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000738,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000739,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000740,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000741,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000742,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000743,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000744,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000745,AFR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000746,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000747,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000748,AFR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000749,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000750,AMR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000751,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000752,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000753,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000754,AFR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000755,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000756,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000757,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000758,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000759,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000760,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000761,EAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000762,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000763,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000764,EUR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000765,AMR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000766,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000767,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000768,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000769,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000770,EAS,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000771,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000772,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000773,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000774,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000775,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000776,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000777,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000778,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000779,EAS,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000780,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000781,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000782,AMR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000783,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000784,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000785,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000786,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000787,AMR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000788,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000789,EAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000790,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000791,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000792,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000793,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000794,EUR,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000795,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000796,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000797,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000798,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000799,EAS,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000800,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,biallelic_path,B,False,Increased colorectal cancer risk -- surveillance colonoscopy
HLT013_000801,EAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000802,EUR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000803,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000804,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000805,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,False,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000806,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000807,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000808,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000809,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000810,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000811,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000812,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000813,SAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000814,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000815,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000816,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000817,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000818,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000819,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000820,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000821,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000822,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000823,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000824,EAS,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000825,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000826,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000827,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000828,EUR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000829,AMR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000830,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000831,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000832,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000833,EUR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000834,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000835,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000836,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000837,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000838,SAS,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000839,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000840,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000841,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000842,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000843,AFR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000844,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000845,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000846,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000847,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000848,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000849,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000850,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000851,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000852,EUR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000853,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000854,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000855,EUR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
HLT013_000856,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000857,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000858,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000859,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000860,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000861,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000862,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000863,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000864,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000865,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000866,AMR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000867,AMR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000868,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000869,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000870,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000871,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000872,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000873,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000874,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000875,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000876,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000877,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000878,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000879,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000880,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000881,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000882,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000883,SAS,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000884,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000885,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000886,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000887,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000888,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000889,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000890,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000891,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000892,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000893,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000894,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000895,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000896,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000897,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000898,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000899,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000900,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000901,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000902,EUR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000903,EUR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000904,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000905,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000906,EAS,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000907,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000908,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000909,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000910,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000911,EAS,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000912,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000913,AMR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000914,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000915,SAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000916,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000917,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000918,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000919,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000920,AFR,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000921,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000922,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000923,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000924,AFR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000925,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000926,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000927,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000928,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000929,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000930,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000931,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
HLT013_000932,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000933,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000934,EAS,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000935,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000936,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000937,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000938,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000939,AMR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000940,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000941,EUR,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000942,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000943,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000944,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
HLT013_000945,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000946,EUR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000947,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000948,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000949,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000950,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000951,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000952,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000953,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000954,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000955,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000956,AMR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000957,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000958,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000959,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000960,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000961,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000962,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000963,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000964,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000965,SAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000966,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000967,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000968,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000969,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000970,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000971,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000972,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000973,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000974,AMR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000975,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000976,EAS,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000977,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000978,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000979,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000980,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000981,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000982,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000983,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000984,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000985,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000986,SAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000987,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000988,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000989,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000990,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000991,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000992,EAS,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000993,EAS,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000994,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000995,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000996,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000997,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000998,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_000999,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
HLT013_001000,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing