diff --git "a/pharmacogenomics.csv" "b/pharmacogenomics.csv"
new file mode 100644--- /dev/null
+++ "b/pharmacogenomics.csv"
@@ -0,0 +1,1001 @@
+sample_id,ancestry,PGx_CYP2D6_class,PGx_CYP2D6_CPIC,PGx_CYP2D6_ACMG_actionable,PGx_CYP2D6_recommendation,PGx_CYP2C19_class,PGx_CYP2C19_CPIC,PGx_CYP2C19_ACMG_actionable,PGx_CYP2C19_recommendation,PGx_CYP2C9_class,PGx_CYP2C9_CPIC,PGx_CYP2C9_ACMG_actionable,PGx_CYP2C9_recommendation,PGx_CYP3A5_class,PGx_CYP3A5_CPIC,PGx_CYP3A5_ACMG_actionable,PGx_CYP3A5_recommendation,PGx_TPMT_class,PGx_TPMT_CPIC,PGx_TPMT_ACMG_actionable,PGx_TPMT_recommendation,PGx_DPYD_class,PGx_DPYD_CPIC,PGx_DPYD_ACMG_actionable,PGx_DPYD_recommendation,PGx_UGT1A1_class,PGx_UGT1A1_CPIC,PGx_UGT1A1_ACMG_actionable,PGx_UGT1A1_recommendation,PGx_SLCO1B1_class,PGx_SLCO1B1_CPIC,PGx_SLCO1B1_ACMG_actionable,PGx_SLCO1B1_recommendation,PGx_G6PD_class,PGx_G6PD_CPIC,PGx_G6PD_ACMG_actionable,PGx_G6PD_recommendation,PGx_VKORC1_class,PGx_VKORC1_CPIC,PGx_VKORC1_ACMG_actionable,PGx_VKORC1_recommendation,PGx_HLA_B5701_class,PGx_HLA_B5701_CPIC,PGx_HLA_B5701_ACMG_actionable,PGx_HLA_B5701_recommendation,PGx_HLA_A3101_class,PGx_HLA_A3101_CPIC,PGx_HLA_A3101_ACMG_actionable,PGx_HLA_A3101_recommendation,PGx_CFTR_class,PGx_CFTR_CPIC,PGx_CFTR_ACMG_actionable,PGx_CFTR_recommendation,PGx_BRCA1_class,PGx_BRCA1_CPIC,PGx_BRCA1_ACMG_actionable,PGx_BRCA1_recommendation,PGx_BRCA2_class,PGx_BRCA2_CPIC,PGx_BRCA2_ACMG_actionable,PGx_BRCA2_recommendation,PGx_MLH1_class,PGx_MLH1_CPIC,PGx_MLH1_ACMG_actionable,PGx_MLH1_recommendation,PGx_MSH2_class,PGx_MSH2_CPIC,PGx_MSH2_ACMG_actionable,PGx_MSH2_recommendation,PGx_PALB2_class,PGx_PALB2_CPIC,PGx_PALB2_ACMG_actionable,PGx_PALB2_recommendation,PGx_CHEK2_class,PGx_CHEK2_CPIC,PGx_CHEK2_ACMG_actionable,PGx_CHEK2_recommendation,PGx_ATM_class,PGx_ATM_CPIC,PGx_ATM_ACMG_actionable,PGx_ATM_recommendation,PGx_NBN_class,PGx_NBN_CPIC,PGx_NBN_ACMG_actionable,PGx_NBN_recommendation,PGx_RAD51C_class,PGx_RAD51C_CPIC,PGx_RAD51C_ACMG_actionable,PGx_RAD51C_recommendation,PGx_RET_class,PGx_RET_CPIC,PGx_RET_ACMG_actionable,PGx_RET_recommendation,PGx_APC_class,PGx_APC_CPIC,PGx_APC_ACMG_actionable,PGx_APC_recommendation,PGx_MUTYH_class,PGx_MUTYH_CPIC,PGx_MUTYH_ACMG_actionable,PGx_MUTYH_recommendation
+HLT013_000001,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000002,AFR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000003,AMR,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000004,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000005,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000006,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000007,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000008,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000009,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000010,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000011,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000012,SAS,UM,A,False,Consider alternative drug or higher dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000013,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000014,AMR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000015,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000016,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000017,AFR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000018,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000019,AMR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000020,EAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000021,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000022,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000023,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000024,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000025,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000026,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000027,AFR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000028,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000029,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000030,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000031,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000032,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000033,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000034,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000035,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000036,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000037,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000038,AFR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000039,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000040,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000041,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000042,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000043,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000044,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000045,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000046,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
+HLT013_000047,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000048,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000049,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000050,EUR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000051,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000052,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000053,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000054,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000055,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000056,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
+HLT013_000057,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000058,AFR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000059,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000060,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000061,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000062,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000063,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000064,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000065,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000066,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000067,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000068,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000069,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000070,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000071,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000072,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000073,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
+HLT013_000074,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000075,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000076,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000077,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000078,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000079,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000080,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000081,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000082,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000083,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000084,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000085,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000086,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000087,EAS,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000088,AFR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000089,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000090,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000091,EUR,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000092,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000093,AFR,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000094,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000095,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000096,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
+HLT013_000097,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000098,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000099,EUR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000100,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000101,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000102,EAS,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000103,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000104,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000105,EAS,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000106,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000107,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000108,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000109,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000110,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000111,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000112,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000113,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000114,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000115,EUR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000116,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000117,EAS,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000118,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000119,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000120,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000121,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000122,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000123,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000124,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000125,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000126,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000127,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000128,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000129,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000130,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000131,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000132,SAS,UM,A,False,Consider alternative drug or higher dose,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000133,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000134,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000135,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000136,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000137,SAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000138,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000139,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000140,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000141,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000142,AFR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000143,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000144,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000145,AFR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000146,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000147,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000148,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000149,AFR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000150,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000151,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000152,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000153,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000154,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000155,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000156,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000157,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000158,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000159,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000160,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000161,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000162,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000163,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000164,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000165,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000166,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000167,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000168,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000169,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000170,SAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000171,EUR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000172,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000173,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000174,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000175,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000176,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000177,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000178,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000179,AMR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000180,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000181,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000182,AMR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000183,AFR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000184,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000185,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000186,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000187,EUR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000188,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000189,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000190,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000191,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000192,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000193,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000194,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000195,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000196,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000197,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000198,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000199,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000200,EUR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000201,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000202,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000203,AFR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000204,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000205,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000206,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000207,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000208,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000209,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000210,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000211,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000212,AFR,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000213,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000214,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000215,EAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000216,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000217,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000218,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000219,SAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000220,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000221,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000222,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000223,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000224,SAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000225,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000226,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000227,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000228,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000229,EAS,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000230,EUR,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000231,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000232,AFR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000233,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000234,AFR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000235,SAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000236,AMR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000237,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000238,EAS,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000239,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000240,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000241,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000242,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,VUS,B,False,Variant of uncertain significance -- monitoring advised,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000243,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000244,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000245,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000246,AMR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
+HLT013_000247,EAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000248,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000249,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000250,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000251,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000252,AMR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000253,AFR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000254,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000255,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000256,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000257,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000258,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000259,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000260,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000261,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000262,AMR,UM,A,False,Consider alternative drug or higher dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000263,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000264,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000265,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000266,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000267,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000268,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000269,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000270,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000271,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000272,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000273,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000274,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000275,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000276,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000277,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000278,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000279,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000280,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000281,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000282,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000283,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000284,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000285,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000286,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000287,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000288,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000289,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000290,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000291,AMR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000292,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000293,SAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000294,EUR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000295,AMR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000296,AMR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000297,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000298,AMR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000299,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000300,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000301,EAS,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000302,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000303,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000304,AFR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000305,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000306,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000307,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000308,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000309,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000310,EUR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000311,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000312,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000313,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000314,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000315,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000316,EUR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000317,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000318,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000319,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000320,SAS,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000321,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000322,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000323,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000324,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000325,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000326,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000327,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000328,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000329,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000330,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000331,EAS,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000332,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000333,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000334,AMR,UM,A,False,Consider alternative drug or higher dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000335,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000336,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000337,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000338,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000339,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000340,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000341,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000342,SAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000343,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000344,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000345,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000346,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000347,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000348,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000349,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000350,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000351,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000352,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000353,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000354,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000355,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000356,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000357,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000358,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000359,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000360,AFR,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000361,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000362,EUR,UM,A,False,Consider alternative drug or higher dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000363,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,biallelic_path,B,False,Increased colorectal cancer risk -- surveillance colonoscopy
+HLT013_000364,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000365,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000366,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000367,EAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000368,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000369,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000370,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000371,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000372,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000373,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000374,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000375,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000376,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000377,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000378,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000379,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000380,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000381,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000382,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000383,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000384,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000385,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000386,SAS,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000387,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000388,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000389,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000390,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000391,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000392,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000393,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000394,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000395,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000396,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000397,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000398,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000399,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000400,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000401,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000402,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000403,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000404,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000405,SAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000406,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000407,EUR,UM,A,False,Consider alternative drug or higher dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000408,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000409,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000410,SAS,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000411,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000412,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000413,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000414,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000415,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000416,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000417,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000418,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000419,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000420,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000421,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000422,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000423,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000424,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000425,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000426,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000427,EUR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000428,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000429,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000430,AMR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
+HLT013_000431,SAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000432,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000433,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000434,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000435,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000436,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000437,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000438,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000439,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000440,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000441,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000442,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000443,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000444,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000445,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000446,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000447,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000448,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000449,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000450,EAS,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000451,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000452,AMR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000453,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000454,EUR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000455,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000456,EUR,PM,A,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000457,SAS,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000458,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000459,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000460,EAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000461,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000462,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000463,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000464,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000465,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000466,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000467,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000468,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000469,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000470,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000471,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000472,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000473,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000474,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000475,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000476,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000477,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000478,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000479,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000480,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000481,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000482,EUR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000483,AFR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000484,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000485,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000486,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000487,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000488,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000489,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000490,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,VUS,B,False,Variant of uncertain significance -- monitoring advised,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000491,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000492,EAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000493,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000494,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000495,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000496,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000497,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000498,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000499,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000500,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000501,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000502,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000503,SAS,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000504,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000505,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000506,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000507,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000508,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000509,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000510,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000511,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000512,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000513,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000514,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000515,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000516,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000517,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000518,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000519,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000520,AMR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000521,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
+HLT013_000522,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000523,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000524,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
+HLT013_000525,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000526,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000527,SAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000528,SAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000529,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000530,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000531,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000532,EAS,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000533,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000534,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000535,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000536,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000537,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000538,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000539,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000540,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000541,SAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000542,AFR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000543,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000544,SAS,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000545,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000546,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000547,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000548,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000549,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000550,AFR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000551,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000552,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000553,EUR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000554,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000555,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000556,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000557,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000558,AFR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000559,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000560,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000561,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000562,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000563,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000564,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000565,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000566,EAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000567,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000568,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000569,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000570,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000571,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000572,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000573,AFR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000574,EAS,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000575,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000576,AFR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000577,AMR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000578,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000579,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000580,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000581,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000582,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000583,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000584,EUR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000585,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000586,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000587,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000588,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000589,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000590,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000591,SAS,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000592,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000593,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000594,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000595,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000596,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000597,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000598,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000599,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000600,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000601,AFR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000602,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000603,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000604,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000605,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000606,EAS,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000607,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000608,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000609,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000610,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000611,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000612,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000613,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000614,SAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000615,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000616,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000617,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000618,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000619,EUR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000620,EUR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000621,EAS,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000622,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000623,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000624,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000625,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000626,AFR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000627,EAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000628,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000629,AFR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000630,AMR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000631,SAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000632,AMR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000633,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000634,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000635,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000636,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000637,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000638,EAS,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000639,EAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000640,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000641,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000642,AMR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000643,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000644,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000645,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000646,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000647,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000648,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000649,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000650,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000651,AFR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000652,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000653,EAS,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000654,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000655,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000656,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000657,AMR,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000658,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000659,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000660,EUR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000661,EUR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000662,AMR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000663,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000664,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000665,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000666,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000667,AMR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000668,SAS,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000669,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000670,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000671,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000672,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000673,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000674,EAS,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000675,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000676,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000677,AMR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000678,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000679,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000680,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000681,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000682,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000683,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000684,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000685,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000686,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000687,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000688,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000689,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000690,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000691,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000692,AMR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000693,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000694,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000695,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000696,AFR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000697,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000698,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,PM,A,False,Consider alternative therapy or reduce dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000699,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000700,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000701,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000702,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000703,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000704,AMR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000705,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000706,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000707,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000708,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000709,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000710,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000711,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000712,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000713,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000714,AMR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000715,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000716,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000717,AFR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000718,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000719,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000720,SAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000721,AFR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000722,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000723,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000724,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000725,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000726,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000727,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000728,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000729,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000730,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000731,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000732,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000733,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000734,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000735,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000736,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000737,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000738,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000739,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000740,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000741,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000742,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000743,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000744,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000745,AFR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000746,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000747,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000748,AFR,RM,A,False,Monitor for reduced efficacy,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000749,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000750,AMR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000751,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000752,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000753,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000754,AFR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000755,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000756,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000757,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000758,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000759,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000760,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000761,EAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000762,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000763,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000764,EUR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000765,AMR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000766,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000767,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000768,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000769,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000770,EAS,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000771,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000772,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000773,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000774,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000775,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000776,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000777,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000778,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000779,EAS,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000780,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000781,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000782,AMR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000783,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000784,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000785,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000786,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000787,AMR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000788,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000789,EAS,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000790,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000791,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000792,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000793,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000794,EUR,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000795,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000796,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000797,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000798,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000799,EAS,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000800,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,biallelic_path,B,False,Increased colorectal cancer risk -- surveillance colonoscopy
+HLT013_000801,EAS,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000802,EUR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000803,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000804,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000805,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,False,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000806,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000807,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000808,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000809,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000810,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000811,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000812,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000813,SAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000814,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000815,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000816,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000817,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000818,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000819,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000820,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000821,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000822,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000823,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000824,EAS,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000825,AMR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000826,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000827,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000828,EUR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000829,AMR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000830,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000831,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000832,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000833,EUR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000834,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000835,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000836,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000837,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000838,SAS,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000839,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000840,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000841,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000842,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000843,AFR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000844,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000845,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000846,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000847,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000848,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000849,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000850,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000851,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000852,EUR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000853,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000854,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000855,EUR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised
+HLT013_000856,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000857,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000858,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000859,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000860,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000861,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000862,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000863,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000864,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000865,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000866,AMR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000867,AMR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000868,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000869,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000870,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000871,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000872,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000873,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000874,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000875,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000876,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000877,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000878,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000879,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000880,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000881,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000882,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000883,SAS,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000884,AFR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000885,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000886,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000887,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000888,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000889,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000890,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000891,EUR,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000892,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000893,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000894,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,UM,B,False,Consider alternative drug or higher dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000895,EAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000896,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000897,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000898,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000899,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000900,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000901,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000902,EUR,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000903,EUR,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000904,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000905,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000906,EAS,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000907,AFR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000908,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000909,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000910,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000911,EAS,PM,A,False,Consider alternative therapy or reduce dose,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000912,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000913,AMR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000914,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000915,SAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000916,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000917,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000918,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000919,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000920,AFR,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000921,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000922,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000923,EAS,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000924,AFR,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000925,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000926,EUR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000927,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000928,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000929,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000930,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000931,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing
+HLT013_000932,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000933,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000934,EAS,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000935,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000936,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,other_path,B,False,Evaluate for CFTR modulator eligibility,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000937,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000938,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000939,AMR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000940,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,pathogenic,B,True,Pathogenic variant identified -- genetic counseling recommended,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000941,EUR,PM,A,False,Consider alternative therapy or reduce dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000942,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000943,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000944,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,monoallelic_path,B,False,Moderate CRC risk -- consider surveillance
+HLT013_000945,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000946,EUR,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000947,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000948,AMR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000949,AMR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000950,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000951,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000952,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000953,EUR,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000954,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000955,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000956,AMR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000957,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000958,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,F508del_het,B,False,Partial CFTR modulator eligibility -- genotype-guided,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000959,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000960,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000961,AFR,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000962,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000963,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000964,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000965,SAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000966,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,A,False,Consider alternative therapy or reduce dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000967,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000968,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000969,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000970,EUR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000971,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000972,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000973,EUR,PM,A,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000974,AMR,UM,A,False,Consider alternative drug or higher dose,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000975,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000976,EAS,RM,A,False,Monitor for reduced efficacy,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000977,AFR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000978,AFR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000979,AFR,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000980,EUR,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000981,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000982,AMR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000983,EAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000984,AFR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000985,EUR,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000986,SAS,PM,A,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,decreased,A,False,Risk of myopathy -- use low dose or alternative,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000987,EUR,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000988,EUR,IM,A,False,Consider lower starting dose,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000989,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,B,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000990,EAS,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000991,EAS,NM,A,False,Standard dosing per label,RM,A,False,Monitor for reduced efficacy,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000992,EAS,IM,A,False,Consider lower starting dose,RM,A,False,Monitor for reduced efficacy,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,UM,B,False,Consider alternative drug or higher dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,high_dose,B,False,Warfarin -- higher dose may be required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000993,EAS,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,increased,A,False,Normal transport -- standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000994,EUR,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,deficient,A,False,Avoid oxidant drugs,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000995,SAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000996,AFR,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,positive,A,True,Avoid abacavir (HLA-B*57:01) / carbamazepine (HLA-A*31:01),negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000997,EAS,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,VUS,B,False,Variant of uncertain significance -- monitoring advised,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000998,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,IM,A,False,Consider lower starting dose,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_000999,SAS,NM,A,False,Standard dosing per label,IM,A,False,Consider lower starting dose,IM,A,False,Consider lower starting dose,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,NM,B,False,Standard dosing per label,normal,A,False,Standard dosing,normal,A,False,Standard dosing,standard,B,False,Warfarin -- standard initial dose,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing
+HLT013_001000,EUR,NM,A,False,Standard dosing per label,UM,A,False,Consider alternative drug or higher dose,NM,A,False,Standard dosing per label,PM,B,False,Consider alternative therapy or reduce dose,NM,A,False,Standard dosing per label,NM,A,False,Standard dosing per label,IM,B,False,Consider lower starting dose,normal,A,False,Standard dosing,normal,A,False,Standard dosing,low_dose,B,False,Warfarin -- lower dose required,negative,A,False,No HLA contraindication identified,negative,A,False,No HLA contraindication identified,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing,normal,B,False,Standard dosing