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{
  "sku": "HLT011",
  "module": "Clinical Trial Eligibility Engine",
  "generated_at": "2026-05-17T19:32:31.716145",
  "seed": 42,
  "n_patients": 1500,
  "n_trial_templates": 15,
  "eligibility": {
    "overall_rate": 0.78,
    "mean_score": 0.701,
    "score_std": 0.177
  },
  "enrollment": {
    "total_enrolled": 467,
    "unique_patients": 467,
    "trials_meeting_target": 0,
    "mean_screen_fail_rate": 0.315
  },
  "endpoints": {
    "total_assessments": 2689,
    "responder_rate_active_arm": 0.711,
    "protocol_deviation_rate": 0.076,
    "withdrawal_rate": 0.008
  },
  "trials": [
    {
      "trial_id": "TRIAL-GD-001",
      "disease": "Gaucher Disease Type 1",
      "phase": "Phase 3",
      "n_target": 120
    },
    {
      "trial_id": "TRIAL-SMA-001",
      "disease": "Spinal Muscular Atrophy",
      "phase": "Phase 3",
      "n_target": 80
    },
    {
      "trial_id": "TRIAL-CF-001",
      "disease": "Cystic Fibrosis",
      "phase": "Phase 3",
      "n_target": 200
    },
    {
      "trial_id": "TRIAL-DMD-001",
      "disease": "Duchenne Muscular Dystrophy",
      "phase": "Phase 2/3",
      "n_target": 60
    },
    {
      "trial_id": "TRIAL-HD-001",
      "disease": "Huntington Disease",
      "phase": "Phase 2/3",
      "n_target": 100
    },
    {
      "trial_id": "TRIAL-FAB-001",
      "disease": "Fabry Disease",
      "phase": "Phase 3",
      "n_target": 90
    },
    {
      "trial_id": "TRIAL-MFS-001",
      "disease": "Marfan Syndrome",
      "phase": "Phase 3",
      "n_target": 150
    },
    {
      "trial_id": "TRIAL-HEM-001",
      "disease": "Hemophilia A",
      "phase": "Phase 3",
      "n_target": 70
    },
    {
      "trial_id": "TRIAL-PKD-001",
      "disease": "ADPKD",
      "phase": "Phase 3",
      "n_target": 180
    },
    {
      "trial_id": "TRIAL-OI-001",
      "disease": "Osteogenesis Imperfecta",
      "phase": "Phase 2/3",
      "n_target": 100
    },
    {
      "trial_id": "TRIAL-TS-001",
      "disease": "Tuberous Sclerosis",
      "phase": "Phase 3",
      "n_target": 80
    },
    {
      "trial_id": "TRIAL-SCD-001",
      "disease": "Sickle Cell Disease",
      "phase": "Phase 3",
      "n_target": 75
    },
    {
      "trial_id": "TRIAL-NPC-001",
      "disease": "Niemann-Pick Type C",
      "phase": "Phase 2/3",
      "n_target": 50
    },
    {
      "trial_id": "TRIAL-LCA-001",
      "disease": "Leber Congenital Amaurosis",
      "phase": "Phase 3",
      "n_target": 40
    },
    {
      "trial_id": "TRIAL-CAH-001",
      "disease": "Congenital Adrenal Hyperplasia",
      "phase": "Phase 3",
      "n_target": 110
    }
  ]
}