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HLT-003 SIMULATION ENGINE — AUDIT LOG
XpertSystems.ai · Synthetic Data Factory
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Generated:          2026-05-17 13:32:31 UTC
Engine Version:     1.0
Trial ID:           HLT003-ONC-TTE-001
Therapeutic Area:   Oncology
Trial Phase:        II
Endpoint Type:      TTE
Seed:               42
N Participants:     600
N Arms:             2
Elapsed:            0.05s

ARM CONFIGURATION
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  Arm 0: SoC Chemotherapy     | d=0.00 | AE mult=1.0
  Arm 1: Targeted Therapy     | d=0.30 | AE mult=1.3

RESULTS SUMMARY
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  Arm 0 [SoC Chemotherapy]:
    n = 301
    Dropout = 8.6%
    Events = 180 (59.8%)
    AEs (mean) = 4.7
    Grade 3+ AEs (mean) = 1.9
    SAEs (mean) = 1.00
  Arm 1 [Targeted Therapy]:
    n = 299
    Dropout = 8.4%
    Events = 160 (53.5%)
    AEs (mean) = 6.1
    Grade 3+ AEs (mean) = 2.9
    SAEs (mean) = 1.64

REPRODUCIBILITY
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  Re-run command: python hlt003_simulation_engine.py --seed 42
  All outputs are deterministic with this seed.

OUTPUT FILES
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  /home/claude/hlt003_work/hlt003_sample/oncology_pfs_trial.csv
  trial_config_schema.json
  simulation_audit_log.txt
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