Weekly COVID-19 Update – Jan. 8, 2021: DPH Announces First Pediatric COVID-19 Death in Delaware
Delaware Health and Social Services | Division of Public Health | News | Date Posted: Friday, January 8, 2021
DOVER (Jan. 8, 2021) – The Delaware Division of Public Health (DPH) is providing an update on the most recent statistics related to coronavirus disease 2019 (COVID-19) in Delaware, as of 6 p.m. Thursday, January 7, 2021.
DPH is reporting the state's first COVID-19 related death of a child since the start of the pandemic. The death involves a child under the age of 5 from New Castle County who had a significant number of co-morbidities. Additional details about the individual will not be provided to protect patient privacy.
"While each life lost as a result of this virus is tragic, the loss of a child is felt across our entire community," said DPH Director Dr. Karyl Rattay. "We send our deepest condolences to this child's family and all of those who have lost a loved one during this pandemic. We are urging everyone in our state to come together, take this current winter surge seriously, remain vigilant about mitigation measures, and keep each other safe."
A total of 957 Delawareans have passed away due to complications from COVID-19. The state reported 31 additional deaths since last week's update. The total number of individuals who have died from COVID-19 ranges in age from younger than 5 to 104 years old. Of those who have died, 487 were female and 470 were male. A total of 476 individuals were from New Castle County, 171 were from Kent County, and 310 were from Sussex County.
A total of 63,503 positive cases of COVID-19 among Delaware residents have been reported to DPH since March 11, 2020. A record number of new positive cases (1,241 positive cases) were reported on Wednesday this week, and the seven-day average increased to 778.6 as of Thursday, Jan. 7.
The seven-day average for the percentage of persons who tested positive for COVID-19 as of Thursday, Jan. 7 was 27.3%, an increase from 25.1% as of Thursday, Dec. 31. DPH publishes both positivity rates – persons tested and total tests conducted – on its COVID-19 data portal. As of Tuesday, Jan. 5, the seven-day average for the percentage of total tests that were positive was 10.4%, an increase from 9.1% as of Tuesday, Dec. 29. There is a two-day lag for presenting data related to percent of tests that are positive to account for the time delay between the date of the test and the date that DPH receives the test result.
In addition, 451 individuals are currently hospitalized due to COVID-19 in Delaware, an increase of 39 as of last Thursday. Fifty-nine of the hospitalized persons are critically ill, up one from last week.
As of midnight, Thursday, Jan. 7, 21,814 administered doses of the COVID-19 vaccine have been reported to the state's immunization information system, DelVAX. Delaware's latest COVID-19 vaccination statistics can be found under the Vaccine Tracker dashboard at de.gov/healthycommunity. Additional information about COVID-19 vaccine rollout is available at de.gov/covidvaccine. Questions can be directed to the Vaccine Call Center at 1-833-643-1715. People who are deaf and hard of hearing should call 2-1-1 or text their ZIP code to 898-211. Individuals can email their questions concerning the vaccine to Vaccine@Delaware.gov.
Update on COVID-19 Outbreaks in Long-term Care Facilities: The Division of Public Health continues to investigate COVID-19 outbreaks in long-term care facilities throughout the state. The following facilities have experienced significant outbreaks since late September. Resident and staff tallies represent cumulative case totals between Sept. 25, 2020, and Jan. 7, 2020, and may not represent the number of active cases at each facility at this particular point in time:
• Atlantic Shores Rehabilitation & Health Center in Millsboro; 21 residents and 18 staff
• Brandywine Assisted Living at Seaside in Rehoboth Beach; 39 residents and 15 staff
• Brookdale in Dover; 58 residents and 36 staff
• Cadia Healthcare Broadmeadow in Middletown; 20 residents and 25 staff
• Cadia Healthcare Renaissance in Millsboro; 22 residents and 20 staff
• Cadia Healthcare Silverside in Wilmington; 58 residents and 46 staff members
• Cadia Healthcare Capitol in Dover; 47 residents and 34 staff
• Churchman Village in Newark; 63 residents and 47 staff
• Delmar Nursing and Rehabilitation Center in Delmar; 38 residents and 38 staff
• Dover Place in Dover; 39 residents and 23 staff
• Foulk Manor South in Wilmington; 29 residents and 30 staff
• Harbor Healthcare and Rehabilitation Center in Lewes; 51 residents and 23 staff
• Hillside Center in Wilmington; 23 residents and 18 staff
• Kutz Senior Living in Wilmington; 33 residents and 20 staff
• Lofland Park in Seaford; 19 residents and 17 staff
• ManorCare Health Services in Wilmington; 11 residents and 18 staff
• Milford Center, Genesis Healthcare in Milford; 49 residents and 14 staff
• Oak Bridge Terrace at Cokesbury Village in Hockessin; 16 residents and 14 staff
• Regal Heights Healthcare and Rehabilitation Center in Hockessin; 90 residents and 41 staff
• Regency Healthcare and Rehabilitation Center in Wilmington; 74 residents and 47 staff
• Seaford Center Nursing Home in Seaford; 21 residents and 19 staff
• The Moorings at Lewes in Lewes; 17 residents and 39 staff
• Westminster Village in Dover; 47 residents and 29 staff
• WillowBrooke Court Skilled Center at Manor House in Seaford; 44 residents and 36 staff
• WillowBrooke Court at Cokesbury Village in Hockessin; 13 residents and 14 staff
*Staff members may include health care and non-health care personnel, such as facility vendors or other individuals working in the long-term care facility who may not be full-time facility employees. Facilities listed represent those that have had a cumulative total of more than 10 cases among residents and more than 10 cases among staff to date since the beginning of the outbreak monitoring period, Sept. 25, 2020. As facility outbreak investigations close, they will be removed from this list.
Long-term Care Statistics:
As of 6 p.m. Thursday, January 7, there have been a total of 1,980 positive COVID-19 cases cumulatively involving long-term care residents, and 512 residents of Delaware long-term care facilities have died from complications related to COVID-19.
The locations and number of deaths involving residents of long-term care facilities are:
Atlantic Shores Rehabilitation and Health Center, Millsboro (18)
Brackenville Center, Genesis Healthcare, Hockessin (18)
Brandywine Nursing and Rehabilitation Center, Wilmington (34)
Brandywine Living at Seaside Pointe, Rehoboth Beach (4)
Brookdale Dover, Dover (9)
Cadia Healthcare Broadmeadow, Middletown (13)
Cadia Healthcare Capitol, Dover (18)
Cadia Healthcare Renaissance, Millsboro (10)
Cadia Healthcare North Wilmington/Silverside, Wilmington (26)
Churchman Village, Newark (7)
Country Rest Home, Greenwood (11)
Delaware Hospital for the Chronically Ill, Smyrna (13)
Dover Place, Dover (4)
Foulk Manor South, Wilmington (3)
Forwood Manor, Wilmington (2)
Governor Bacon Health Center, Delaware City (1)
HarborChase of Wilmington, Wilmington (4)
Harbor Healthcare and Rehabilitation, Lewes (24)
Harrison House Senior Living, Georgetown (43)
Hillside Center, Wilmington (4)
Kentmere Rehabilitation and Healthcare Center, Wilmington (8)
Kutz Senior Living, Wilmington (3)
Little Sisters of the Poor, Newark (11)
Lofland Park Center, Genesis Healthcare, Seaford (6)
ManorCare Health Services, Wilmington (14)
ManorCare Health Services, Pike Creek (23)
Methodist Country House, Wilmington (4)
Millcroft, Newark (2)
Milford Center, Genesis Healthcare, Milford (40)
New Castle Health and Rehabilitation Center, New Castle (12)
Newark Manor Nursing Home, Newark (11)
Parkview Nursing and Rehabilitation, Wilmington (26)
Pinnacle Rehabilitation and Health Center, Smyrna (24)
Regal Heights Healthcare and Rehabilitation Center, Hockessin (11)
Regency Healthcare and Rehabilitation Center, Wilmington (8)
Somerford House and Place, Newark (2)
Summit Assisted Living, Hockessin (3)
Sunrise Assisted Living, Wilmington (2)
The Center at Eden Hill, Dover (2)
The Moorings at Lewes, Lewes (4)
Westminster Village, Dover (13)
WillowBrooke Court Skilled Center at Manor House, Seaford (7)
WillowBrooke Court at Cokesbury Village, Hockessin (2)
Five other New Castle County long-term care facilities (1 death at each facility)
Two other Kent County long-term care facility (1 death at this facility)
One other Sussex County long-term care facility (1 death at this facility)
Aggregate K-12 School-Related COVID-19 Statistics:
On Tuesday, Jan. 5, the Division of Public Health launched a new, schools-focused COVID-19 dashboard on its COVID-19 data portal. The dashboard tracks the number of contagious cases among staff and students of Delaware schools, and offer a more detailed picture of COVID-19 infection in school buildings. The new dashboard can be found at myhealthycommunity.dhss.delaware.gov/locations/state/in-person-contagious.
If you are sick with any of the following symptoms, stay home: fever, cough, shortness of breath, sore throat, muscle aches, fatigue, chills, shaking with chills, loss of smell or taste, nausea or vomiting, diarrhea, or headache or congestion or runny nose without a known cause such as allergies. Other symptoms such as abdominal pain or lack of appetite have been identified as potential symptoms related to COVID-19 and may prompt further screening, action or investigation by a primary care provider. If you are sick and need essential supplies, ask someone else to go to the grocery store or the pharmacy to get what you need.
DPH reminds Delawareans that if you believe you have been exposed to someone with COVID-19, or have symptoms of illness, make sure to distance yourself from others, particularly vulnerable populations. Older adults and people of any age with serious underlying medical conditions – including serious heart conditions, chronic lung conditions, including moderate to severe asthma, severe obesity and those who are immunocompromised, including through cancer treatment – may have a higher risk for severe illness from COVID-19.
Information about testing events, including community testing sites, permanent fixed testing sites, and free-standing sites operated by the health care systems and hospitals, will be listed on the testing section of the Delaware coronavirus website at de.gov/gettested.
Delawareans over the age of 18 are encouraged to download COVID Alert DE, Delaware's free exposure notification app to help protect your neighbors while ensuring your privacy. Download on the App Store or Google Play.
Individuals with general questions about COVID-19 should call Delaware 2-1-1, individuals who are deaf or hard of hearing can text their ZIP code to 898-211, or email delaware211@uwde.org. Hours of operation are 8:00 a.m. to 9:00 p.m. Monday through Friday; 9:00 a.m. to 5:00 p.m. Saturday and Sunday. Medically related questions regarding testing, symptoms, and health-related guidance can be submitted by email at DPHCall@delaware.gov.
Individuals who have complaints about individuals violating public gathering restrictions should contact state or local law enforcement. Concerns that a business may be violating operating restrictions should be directed to: HSPContact@delaware.gov. Questions related to business re-openings or operations as businesses re-open should go to COVID19FAQ@delaware.gov. Questions regarding unemployment claims should be emailed to: UIClaims@delaware.gov.
DPH will continue to update the public as more information becomes available. For the latest on Delaware's response, go to de.gov/coronavirus.
Related Topics: Coronavirus, COVID-19


Apple updates MobileMe status after weekend of fixes
By Philip Michaels
After working over the weekend to restore functionality to MobileMe, Apple said on Sunday night that nearly half of the users affected by the ongoing woes plaguing the newly launched online service have e-mail access once more.
About 1 percent of MobileMe's subscribers had been affected by an e-mail outage, Apple confirmed on Friday. The problem was caused when one of Apple's mail servers blocked access to users' MobileMe mail accounts.
By Sunday, Apple said in a post at its MobileMe status page that 40 percent of the affected users now have e-mail access again along with most of their e-mail history restored.
"We turned on web access to [affected subscribers'] current email yesterday and the feedback has been cautiously positive," the post reads. "Since then, we've restored full email history (minus the approximately 10% of mail received between July 18 and July 22 which may have been lost) and the ability to access email from a Mac, PC and iPhone, to over 40% of these users, and expect the remainder to be restored in the next few days."
Apple adds that e-mail received by users affected by the outage between July 18 and July 22 was placed on its new server with a July 23 date stamp. "If you need the actual date for particular messages you can take advantage of the ability to view long headers in MobileMe Mail (via Preferences) to peer into the log and find the actual mailing time and date," the post adds.
MobileMe, the replacement for Apple's .Mac service, officially launched July 11. The service is aimed at giving users the ability to simultaneously sync mail, contact, and calendar information between computers, iPhones, and other mobile devices.
However, the service has been plagued by problems since launch, a fact Apple acknowledged on July 16 when it apologized for the rocky transition and extended MobileMe subscriptions by 30 days. However, problems have continued for some users, with Apple vowing to have "people… working 24-7 to improve matters."
In Sunday's update on MobileMe service restoration, Apple vowed to post another status report early this week.


Paul: 'Compassion' will grow GOP
knorvell@dmreg.com
DAVENPORT, Ia. — Sen. Rand Paul said he believes to grow the Republican Party and win Iowa the eventual presidential nominee should attract new voters by "showing compassion for people who are down on their luck."
The Republican presidential hopeful said in Knoxville, Ia., he's the candidate who can reach out to voters who have left the party behind — or Democrats thinking of doing the same. The biggest problem, he said, is a Republican hasn't won Iowa in the general election for eight years because the party lacks diversity.
A way to build that base is to attract the youth vote by "being more boldly for what we're for" but also recognizing that some people "deserve a second chance in life," Paul said.
"Do we need to be big spending liberals on this? No," he said. "But I think we need to have compassion for people who are down on their luck and aren't doing well, whether they've gotten in trouble with the law or whether they're in trouble because of poverty."
In Davenport later, the Kentucky senator expanded on his position by touting his record on criminal justice reform — a point he hammered in Thursday's debate by condemning the disproportionate number of black men in prison for non-violent crimes. He has introduced several bills in the U.S. Senate that would eliminate mandatory minimum sentences, expunge records for certain drug crimes and restore federal voting rights, he said.
Paul said the biggest impediment to getting a job is a criminal record, and to keep people off welfare there should be a "second chance" for people who have "changed their ways." He would also help lift people out of poverty by creating "economic freedom zones" where taxes are lower in certain pockets of poverty, he said.
"We can have a message that's consistent with what we believe in," Paul said. "Most of us are Christians and believe in redemption and believe in a second chance. I think the law ought to believe that."
Pastor Brian Nolder, of Pella, said in Knoxville he appreciates that Paul introduced a personhood amendment that would define life as beginning at conception, but that "the pro-life ethic also needs to reflect in our foreign policy, as well."
"I'm not a pacifist, Senator Paul is not a pacifist," he said. "But we do need to be really concerned about the way that we go about defending our nation and that we not entangle ourselves in foreign affairs unjustly in a way that's potentially taking innocent life and costing us a lot of money and a lot of blood."
At the events
Setting: The National Sprint Car Hall of Fame and Museum in Knoxville and the Hotel Blackhawk in Davenport.
Crowd: About 50 in Knoxville and more than 150 in Davenport.
Reaction: Both crowds applauded several times, but in Davenport he elicited verbal shouts of agreement on several points, including his desire to re-evaluate the war on drugs and when explaining his 14.5 percent flat tax plan. "I want the government to have less money and you to have more money," he said.
What's next: Paul has a busy schedule through caucus night. Check DesMoinesRegister.com for more details.


Country Weekly Archive
Tag Archives: Mark O'Connor
2017 Grammy Awards: Country Music Winners List [Updated]
The 59th Grammy Awards are underway in LA, and we'll be posting the winners as they are announced in the country, bluegrass and Americana categories. Best Country Album A Sailor's Guide to Earth — Sturgill Simpson WINNER Big Day in a Small Town — Brandy Clark Full Circle — Loretta Lynn Hero — Maren Morris Ripcord — Keith Urban Best Country…… MORE
Grammy Time
The 62nd Grammy Awards will air live from Los Angeles' Staples Center on Jan. 26 on CBS at 8 p.m. ET/5 p.m. PT.
The Gatlin Brothers Announce "65th Anniversary Tour"
Luke Bryan Announces New Album, "Born Here, Live Here, Die Here," and New Tour
Jason Aldean Extends "We Back Tour" With Brett Young, Mitchell Tenpenny & More
Chris Young Announces "Town Ain't Big Enough Tour" With Scotty McCreery
Brooks & Dunn to Hit the Road for "Reboot 2020 Tour"
Tim McGraw Announces "Here On Earth Tour" With Midland, Ingrid Andress & 2 Shows With Special Guest Luke Combs
Charlie Daniels Band & Marshall Tucker Band Join Forces for "Fire on the Mountain Tour"
Zac Brown Band Announces "Roar With the Lions Tour"
Canaan Smith Announces "Pour Decisions Tour"
2020 Bonnaroo Lineup Includes Jason Isbell, Morgan Wallen, Yola & More [Full Lineup]


Aberdeen Reports Shareholders' Equity of $0.37 Per Share and 2015 Year End Financial Results
TORONTO, ONTARIO--(Marketwired - May 4, 2015) - Aberdeen International Inc. ("Aberdeen") (TSX:AAB) ("Aberdeen", or the "Company") is pleased to announce that it has released its financial results for the fourth quarter of 2015, for the period ended January 31, 2015. For more information please see the Company's Annual Financial Statements and Management's Discussion and Analysis ("MD&A") posted on SEDAR at www.sedar.com.
As at January 31, 2015, Aberdeen's Shareholders' Equity (or Net Asset Value, "NAV") was $35.9 million, or $0.37 per share. Aberdeen's shareholders' equity increased by $4.8 million from $31.1 million at the end of Q3 2015. The increase in shareholders' equity was due to the performance of Aberdeen's equity investment portfolio in the fourth quarter, which had a total investment gain of $2.8 million for the quarter in addition to the Company's $2.0 million equity raise in Q4 2015. On a year-over-year basis, Aberdeen's shareholders' equity decreased by $11.6 million. Note that the reference to shareholders' equity is similar to previous references to Net Asset Value or "NAV" by Aberdeen.
2015 January 31,
2014 October 31,
Shares outstanding 97,349,422 87,349,422 87,349,422
$ $/Shares $ $/Shares $ $/Shares
Cash on hand 355,188 0.00 868,267 0.01 3,167,364 0.04
Publicly traded 18,941,776 0.195 17,216,988 0.197 15,461,756 0.177
Private 17,700,622 0.182 20,075,953 0.230 9,870,765 0.113
Intrinsic value 17,500 0.000 25,000 0.000 - -
Option value 12,500 0.000 545,909 0.006 14,900 0.000
30,000 0.000 570,909 0.007 14,900 0.000
Portfolio Investments 36,672,398 0.377 37,863,850 0.433 25,347,421 0.290
Loans / preferred shares 61,538 0.001 6,902,617 0.079 61,538 0.001
Total 37,089,124 0.381 45,634,734 0.522 28,576,323 0.327
For the twelve months ended January 31, 2015, Aberdeen reported net earnings of $(13.8) million or $(0.15) per basic share on total revenue of $(2.8) million. Revenue was comprised of $(3.0) million from net investment losses and $0.2 million from interest income and dividends. For the twelve months ending January 31, 2014, Aberdeen reported net earnings of $(16.3) million or $(0.19) per share on total revenue of $(13.5) million ($(14.3) million from net investment losses and $0.8 million from interest and dividend income and advisory service fees).
Corporate Update
Aberdeen is pleased that its investment, African Thunder Platinum has announced several important milestones in recent weeks. On March 26, 2015, African Thunder announced the restart of the Smokey Hills Mine in January and on April 29, 2015, announced the successful commissioning of the plant at the end of March with the first PGM concentrate shipment on April 18, 2015. Production continues to improve and management of ATP is confident that the mine is on track to achieve full ramp-up before the end of the year. David Stein also noted, "Aberdeen has been pleased to see the mine start-up as scheduled, and the first concentrate shipment, which signals the first revenue received from ore production at the Smokey Hills Mine. In a few short months, African Thunder has accomplished a number of important milestones which we believe will be instrumental of the development of the project into a growing platinum Company."
The Company continues to implement its five point plan as disclosed in January 2015. In particular:
Subsequent to the year ended January 31, 2015, the Company purchased 691,170 common shares for cancellation under the Company's normal course issue bid ("NCIB") at an average cost of $0.145. Aberdeen expects to continue to purchase shares over the remainder of its NCIB, depending on market conditions and other investment opportunities that may be available.
Subsequent to the year ended January 31, 2015, the Company has implemented a cost reduction program and has reduced its ongoing G&A costs. The Company expects to report more details in its Q1 2016 results.
Aberdeen is also reviewing or engaged in several other opportunities that would allow the Company to earn revenue alongside its investments including interest income, management fees and/or royalties. Aberdeen is pleased to have received its first dividend from its position in Tahoe Resources Inc. in April, and expects to continue to receive income from this holding while the Company reviews other opportunities.
Aberdeen also continues to evaluate further improvements to its corporate governance
Aberdeen is pleased to announce the recent appointment of Rob Hopkins as Manager, Investor Relations. Mr. Hopkins is an experienced investor relations professional who has been focused on the mining sector for the past four years. Investors will have already noticed improved disclosure on our new investments over the past quarter and we ramp up a broader investor relations program and will continue to update the market on these initiatives.
Aberdeen is a publicly traded global investment and merchant banking company focused on small cap companies in the resource sector. Aberdeen will seek to acquire significant equity participation in pre-IPO and/or early stage public resource companies with undeveloped or undervalued high-quality resources. Aberdeen will focus on companies that: (i) are in need of managerial, technical and financial resources to realize their full potential; (ii) are undervalued in foreign capital markets; and/or (iii) operate in jurisdictions with moderate local political risk. Aberdeen will seek to provide value-added managerial and board advisory services to companies. The Corporation's intention will be to optimize the return on its investment over a 24 to 36 month investment time frame.
For additional information, please visit our website at www.aberdeeninternational.ca and follow us on Twitter: @AberdeenAAB.
Except for statements of historical fact contained herein, the information in this press release constitutes "forward-looking information" within the meaning of Canadian securities law. Such forward-looking information may be identified by words such as "plans", "proposes", "estimates", "intends", "expects", "believes", "may", "will" and include without limitation, statements regarding the impact of the appointment on Aberdeen; past success as an indicator of future success; net asset value of the Company; the potential of investee companies and the appreciation of their share price; the future intentions of the Company with regard to its shareholdings; the Company's plan of business operations; timing with respect to proposed transaction, the ability to complete any transactions on the terms proposed, or at all; and anticipated returns. There can be no assurance that such statements will prove to be accurate; actual results and future events could differ materially from such statements. Factors that could cause actual results to differ materially include, among others, metal prices, competition, financing risks, acquisition risks, risks inherent in the mining industry, and regulatory risks. Most of these factors are outside the control of the Company. Investors are cautioned not to put undue reliance on forward-looking information. Except as otherwise required by applicable securities statutes or regulation, the Company expressly disclaims any intent or obligation to update publicly forward-looking information, whether as a result of new information, future events or otherwise.
Rob Hopkins


Our climate is changing, and it is clear that these changes will continue to have an impact on Northern Ireland. This presents a wide range of risks and opportunities to our natural environment, infrastructure services, built environment, economy and other vital societal support structures.
Whilst working to limit the effects of climate change by reducing greenhouse gas emissions, we must adapt. Historical emissions of greenhouse gases have made climate change inevitable, regardless of our emission reductions.
The European Commission defines adaptation as:
"Anticipating the adverse effects of climate change and taking appropriate action to prevent or minimise the damage they can cause, or taking advantage of opportunities that may arise."
https://ec.europa.eu/clima/policies/adaptation_en
Adaptation is essential to better prepare us to respond to current and future changing climatic conditions. Planning for these changes will enable NI to build resilience to the potential negative impacts of climate change, whilst allowing us to take advantage of any opportunities.
See our UK Climate Change Adaptation Policy page to learn about the legislation in place to help the UK and each of its devolved administrations, including Northern Ireland to address climate change.
To learn more about the projected climatic changes, see our
UK Climate Projections 2018 (UKCP18) page. This includes a presentation from the Met Office, which provides an overview of the latest climate projections, the data available and how to access information.
UK Climate Change Adaptation Policy
Adaptation in Northern Ireland
NI Climate Change Research Database


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What are the Benefits of Studying in UK ?
UK higher education and qualifications have a remarkable international reputation and the UK degree is globally by international universities, top employers and government bodies, creating huge number of chances to get placed with leading companies. Along with your studies, you can work in a part-time job, internship or placement and develop valuable skills that will be added to your CV. Your university may assist in providing placement after studies.
Is UK a Good Place to Study ?
Studying in the UK is good value for money – average costs here are lower than in both the USA and Australia. Generally speaking, humanities and social science courses cost the least, while laboratory and clinical degrees are more expensive.
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The new post-study work visa rules will allow you to work in the UK after graduation. From September 2020 any student enrolling at a UK university can stay in the UK after graduation for up to two years in order to look for work related to their degree or course.
Is UK Expensive to Study ?
Budgeting is part of student life! The cost of living in the UK as a student is estimated at around £12,200 per year.
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Evaluation of new antihypertensive drugs designed in silico using Thermolysin as a target
MacLeod Carey, Desmond
Solis Cespedes, Eduardo
Lamazares, Emilio
Mena Ulecia, Karel
SAUDI PHARMACEUTICAL JOURNAL,Vol.28,582-592,2020
The search for new therapies for the treatment of Arterial hypertension is a major concern in the scientific community. Here, we employ a computational biochemistry protocol to evaluate the performance of six compounds (Lig783, Lig1022, Lig1392, Lig2177, Lig3444 and Lig6199) to act as antihypertensive agents. This protocol consists of Docking experiments, efficiency calculations of ligands, molecular dynamics simulations, free energy, pharmacological and toxicological properties predictions (ADME-Tox) of the six ligands against Thermolysin. Our results show that the docked structures had an adequate orientation in the pocket of the Thermolysin enzymes, reproducing the X-ray crystal structure of InhibitorThermolysin complexes in an acceptable way. The most promising candidates to act as antihypertensive agents among the series are Lig2177 and Lig3444. These compounds form the most stable ligandThermolysin complexes according to their binding free energy values obtained in the docking experiments as well as MM-GBSA decomposition analysis calculations. They present the lowest values of Ki, indicating that these ligands bind strongly to Thermolysin. Lig2177 was oriented in the pocket of Thermolysin in such a way that both OH of the dihydroxyl-amino groups to establish hydrogen bond interactions with Glu146 and Glu166. In the same way, Lig3444 interacts with Asp150, Glu143 and Tyr157. Additionally, Lig2177 and Lig3444 fulfill all the requirements established by Lipinski Veber and Pfizer 3/75 rules, indicating that these compounds could be safe compounds to be used as antihypertensive agents. We are confident that our computational biochemistry protocol can be used to evaluate and predict the behavior of a broad range of compounds designed in silicoagainst a protein target. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.


Tags: Japan | quake | baby
Baby Rescued From Japan Quake Rubble
Rescuers dramatically pulled a baby girl from a collapsed house early Friday more than six hours after a swarm of powerful earthquakes rocked southwestern Japan and left nine people dead.
Video footage provided by the National Police Agency showed the tiny pink pajama-clad baby gently carried away in a blanket by helmeted rescuers from the rubble of the home.
The rescue of the eight-month old girl came in the Kumamoto prefectural town of Mashiki, the locale hardest hit by the 6.5-magnitude quake that struck Thursday night.
The girl whose name has not been released, reportedly did not suffer any injuries.
The child's mother, grandfather, grandmother, and older brother were in the living room and kitchen of the home as she slept in another room on the first floor when the quake shook the southern island of Kyushu, the Mainichi Shimbun daily reported.
The family members, who all managed to escape, tried to rescue the baby but the house collapsed, the paper said.
But a 50-member rescue team managed to pull her safely from the rubble around 3:45 am Friday, Kyodo News reported.
The infant's rescue came as nine people were killed -- eight of them in Mashiki -- after dozens of aftershocks shook the area following the initial quake.
Mashiki, a town with the population of about 35,000 people, is near the quake's epicenter.
People following news of the baby's ordeal shared their emotions on Twitter.
"I thought I'd cry," one user wrote. "Hope she is safely back to her mother. She had been a good girl for six hours!"
Another wrote: "So relieved to know the baby is safe. I cannot stop crying."
© AFP 2021
Japan, quake, baby


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DataRobot is building the world's most Trusted AI
Trust is essential in any relationship and must be earned. When you meet a new business partner, you know how to quickly read whether or not they are trustworthy. With an AI system, that sophisticated assessment is just as vital, and it comprises key steps that should become routine.
At DataRobot, we provide the expertise and tools to test your systems across multiple dimensions of trust in order to design AI that performs exceptionally, maintains operational excellence, and reflects your values. This is Trusted AI.
Humility in AI: Building Trustworthy and Ethical AI Systems
DataRobot's Framework for Trusted AI
DataRobot's technology was created by some of the world's top data scientists, incorporating best practices with recent research developments. We recognize that AI trust is multidimensional and an AI creator, operator, and consumer each have different needs. Success happens when humans and AI work together.
The DataRobot platform incorporates guardrails to ensure performance and enable the democratization of AI so that knowledgeable business users across an organization can rely on it.
Value and Risk
With DataRobot's Humble AI feature, you get real-time analysis and protection for the predictions generated by any of your deployed models, making it easier to trust your model and get more value from it.
Ethical and Explainable
Technical and non-technical users must be able to explain AI models in a way that is transparent and reflects your company's values. DataRobot's platform is not a black box and will give you clear and concise explanations for the predictions it produces.
Learn More about Trusted AI
Our white papers, blogs, webinars, case studies, and courses can help you learn more about how trust in AI shapes the decisions of organizations across many different business segments.
Trusted AI 101: A Guide to Building Trustworthy and Ethical AI Systems
Learn about the basic components of trustworthy and ethical AI systems and how to build them. Find out how DataRobot delivers trust in AI.
Ethical AI DataRobot University Course
A seminar that teaches how to identify ethical challenges related to machine learning projects and how to build a framework for developing your organization's ethical AI policy.
In this ebook, we explore the concept of humility in AI systems and how it can be applied to existing solutions to ensure their trustworthiness, ethicality, and reliability in a fast-changing world.
DataRobot in the News
WSJ: Corporate Tech Leaders Are Mixed on EU Artificial Intelligence Bill
Fortune: Europe proposes strict A.I. regulation likely to have an impact around the world
DataRobot Names New Global AI Ethicist
Datanami: AI Bias a Real Concern in Business, Survey Says
Why you need to pay more attention to combatting AI bias
EU AI regulation guidelines worry vendors
How to Stop Worrying and Start Tackling AI Bias
The stories of bias in AI are everywhere: Amazon's recruiting tool, Apple's credit card limits, Google's facial recognition, and dozens more. The quick solution is just to blame the algorithm and its designers. However, the only way to create fairer AI is to understand the true source of the model's bias.
Humble AI: Building Guardrails Against Overconfidence
As AI becomes ubiquitous, more and more high-stakes decisions will be made automatically by machine learning models. AI can determine the very future of your business and can make life-or-death decisions for real people.
The State of AI Bias
While many people believe AI can help solve complex problems plaguing modern societies, can we trust that the AI solutions directing our work and livelihood are rooted in reliable, unbiased data? Do organizations have the proper systems in place to prevent, or quickly address, issues resulting from AI bias?
Data Science Fails: Case Studies and Lessons Learned
In this webinar we discuss 6 case studies in AI failure, and discover how you can avoid becoming yet another data science failure statistic.
Opening Keynote: Trust in AI is not a feature, it's a requirement
Do you trust your AI? As businesses increasingly rely on AI to make predictions—sometimes with life or death outcomes—it's essential that those forecasts are accurate and credible. And there are many ways an AI system can go wrong: inaccuracy, overconfidence, bias, and privacy concerns.
Bringing Trust into AI
In this session, we'll investigate the root cause of bias in machine learning and present DataRobot's framework for implementing more trustworthy AI. You'll come away with a greater awareness of how bias–both explicit and implicit–affects your organization and concrete plan to address it.
Build Fairer and More Equitable AI with Bias Testing
A great deal of research has been done on the negative effects of algorithmic bias, but few templates exist for how organizations can implement Responsible AI. Data scientists need tools to help guide, standardize and operationalize their organizations' Responsible AI policy positions.
Trusted AI 102: A Guide to Building Fair and Unbiased AI Systems
The risk of bias in artificial intelligence (AI) has been the source of much concern and debate. Numerous high-profile examples demonstrate the reality that AI is not a default "neutral" technology and can come to reflect or exacerbate bias encoded in human data. These risks undermine the underlying trust in AI and affect your organization's ability to deliver successful AI projects, unhindered by potential ethical and reputational consequences.
Fostering trust in AI systems is a great obstacle to bringing transformative AI technologies into reality, such as autonomous vehicles or the large-scale integration of machine intelligence in medicine. The challenge is to translate guiding ethical principles and aspirations into implementation and make the responsible practice of AI accessible, reproducible, and achievable for all who engage with the design and use of AI systems. This is a tall order but far from an insurmountable challenge.
Automatic Bias and Fairness Testing
Introducing DataRobot Bias and Fairness Testing
Enabling Trustworthy AI with Digital Risk Mitigation and Cybersecurity
Healthcare, like all industries, is being transformed by the large-scale adoption of digital technologies both at their core value chain and external innovation initiatives. And like all other industries, healthcare is at risk from data breaches, ransomware, and similar attacks. Gaining and keeping the trust of patients, providers, and payers has to be upheld at all cost. Strong cybersecurity is the answer and has been becoming an increasingly strategic asset for this industry's highly sensitive data.
Start trusting your AI system.


Transgender Woman Has Child Porn Conviction Overturned Because She Was 'Struggling With Her Identity'
Vetea Joseph Bunton, 22, was reportedly caught with graphic depictions of child sex on her phone in Jan. 2016. Australian authorities say that Bunton, a transgender "woman" who was 18 at the time, had images on her phone of children having sex with each other as well as children having sex with adults.
"There were a total of 15 images depicting young boys between the age of five years and 16 years posing naked, performing oral sex or engaging in anal intercourse, either with other young people or adults," the court said.
Bunton pleaded guilty in Dec. 2018 to a charge of possessing child exploitation material in the District Court of Burbane. Justice Brian Devereaux gave Bunton leniency the during initial court proceedings in part because of comments she made to forensic psychologist, Dr. Gavan Palk, who apparently vouched for her in his report.
"She does not present as a person who is a risk to children. Her sexual offences appear situational and in the context of low self-esteem and lack of confidence due to teenage sexual adjustment issues," he said. 'There was no evidence of entrenched pedophilic tendencies."
Bunton claimed that she only downloaded the kiddie porn "out of curiosity and at a time when she was struggling with issues concerning her transgender identity and sexual identity." Devereaux noted that none of Bunton's testimony "really excuses obtaining child exploitation material with children as young as five."
Devereaux ultimately sentenced Bunton to two years of probation along with mandatory treatment. She was also required to register as a sex offender under the initial ruling. Even though Bunton avoided any jail time, an appeals court felt that Devereaux's determination was unfair and overturned the conviction for this member of the LGBT community.
A three-judge panel determined that Devereaux's ruling was "inappropriate" and "disproportionate to the real risk she presents by her offending."
"In my respectful view, the applicant's circumstances are unusual," Justice Philip Morrison wrote on behalf of the three-judge panel.
Morrison worried that Bunton's status as a sex offender would affect her transition. He was concerned about "onerous" reporting requirements and the inability to develop an alias as she "undergoes transgender treatment."
The LGBT agenda is causing the disintegration of the rule of law across the West. The recent case of 7-year-old James Younger, who is being transitioned into a girl by his mother in Texas against the wishes of his father, has drawn attention to how the left-wing courts are enabling gender insanity:
Judge Kim Cooks has granted joint custody to the parents of 7-year-old James Younger, a young boy who has been encouraged to transition into a girl by his mother.
Jeffrey Younger and his ex-wife, Dr. Anne Georgulas, have been involved in a bitter court battle over their twin children, James and Jude, for many months now. Georgulas wants to transition James from a boy into a girl named "Luna" and pump him full of puberty blockers before he reaches the age of 10…
Making matters worse, Georgulas is a licensed pediatrician in Coppell, TX. She may be using her authority to push her Mengelean gender beliefs on other unsuspecting parents and children…
This judge's decision is a rare victory for sanity against the pervasive child abuse agenda of the LGBT movement.
Other abominations – like drag queen story hour and pride parades featuring pornographic displays – are regularly occurring throughout the West as well. LGBT activists have proven their critics to be correct as they wage war against traditional morality, as the souls of children hang in the balance.


Men's Basketball Season Ends in Loss to Morrisville State
Morrisville St.
Keuka
Morrisville St. (21-4, 15-1 NEAC) 43 36 79
Keuka (9-14, 6-10 NEAC) 21 37 58
James Barnes (10) led the Wolves with 18 points on Saturday -- Photo by Brooke Overton
Pts: Tyrin Miller - 26
Reb: Kevin Dennis - 13
Ast: Lamel Faison - 8
Pts: James Barnes - 18
Reb: Trevor Powell - 7
KEUKA PARK, N.Y. — The Keuka College Men's Basketball team lost 79-58 to Morrisville State at the JMW Recreation and Athletics Center on Saturday, ending the season for the Wolves.
Keuka College finished the year with a 9-14 record, including a 6-10 mark in the North Eastern Athletic Conference
James Barnes led the Wolves with 18 points against the Mustangs. David Oliveras added 15 points and Trevor Powell finished with 10 in the loss.
Morrisville State 79 at Keuka College 58
The Mustangs jumped out to an early 10-4 lead over the Wolves five minutes into the game on Saturday. Morrisville State pushed the lead to double figures and then went on a 9-0 run to widen the margin. They used the long ball in building their lead, outscoring the Wolves 21-3 from three-point territory. Morrisville State led 43-21 at the half.
Keuka College fought to stay in the game in the second half. The Wolves went on an 8-0, capped by a Trevor Powell three, to cut the margin to 15 points a 57-42. The Green and Gold continued to battle but the Mustangs had an answer for every push by the Wolves as Morrisville State continued onto the 79-58 victory.
KC Notes:
The Wolves fell to 8-13 all-time and 5-5 on David M. Sweet Court against Morrisville State
Keuka College attacked the offensive glass on Saturday, grabbing 17 offensive rebounds
The Wolves took care of the ball, turning it over only nine times against the Mustangs


Water which are included for the air(humidity) and plant production
Caution: This page is made with the purpose of the plant production, and it has been designed for the use in the ordinary temperature in which the crop grows.
Produced By Hoshi, Takehiko, Ph.D. (Tokai University)
Agri-Environment Experiment, Science House Pub. Ed. By Dr. Watanabe, Ichirou
Hand-Book for High-Tech. Agricultue production, Tokai Univ. Press Co., Ed. By Society of High-Technology in Agriculture
The humidity is important as an environmental condition which influences the growth of the plant with temperature and light. There is the relation which is profound with transpiration of the plant, generation of the disease, generation of the mists and fog, stresses of the plant, heating and cooling energy, etc. on the humidity in the air. And, there are various types, even if that the humidity is an index on the water which is included for the air goes to the draft with the humidity. In this page, it is made that the humidity is understood, though you measure the humidity actually, and though it is calculated, to be a purpose.
Measuring method of the humidity
Calculation of the various humidities
Description of the values concerning the humidity
Humidity calculation sheet
Wet and dry bulb thermometers or thermometers and relative humidity meters are necessary in order to measure the humidity. The relative humidity meter is the instrument which measures the result of calling what is called "the 70% humidity", etc. with the humidity generally.
Wet and dry bulb thermometer
It is convenient to use the wet and dry bulb thermometer in order to the most accurately measure. This the gauze has been wound to temperature sensing element of another thermometer by the equipment that 2 thermometers were installed, and it is being inserted in the bottle. It puts the water in this bottle, and the gauze of the temperature sensing element would moisten in the capillarity. And, one side measures the temperature. Showing temperature of the thermometer which moistens in winding the gauze, is called the wet bulb temperature. And, one side is called dry-bulb temperature or temperature only.
Though the simple wet and dry bulb thermometer does not pass the wind at temperature sensing element, it sends and ventilates the wind of about 5m/s wind velocity to the temperature sensing element in order to accurately measure. It is called conformer wet and dry bulb thermometer which ventilates this, and there is the Asman ventilation type wet and dry bulb thermometer as a representative thing.
Thermometer and relative humidity meter
Relative humidity meter is for measuring the relative humidity directly. The humidity is measured using the contraction of cellophane and hair, and the semiconductor is used, and there is relative humidity meter of various structure.
To begin with, the dry-bulb temperature ( air temperature ) is measured, and thereupon, it is written with C. The person who uses wet and dry bulb thermometer in continueing, writes the field: C as wet bulb temperature, or the person who uses relative humidity meter a substitute for the wet bulb temperature writes the field: % as relative humidity. It has been written, and the button is pushed. Various humidity is obtained like the following, when it is done. It is the button, when it wants to already redo the once, and the filling up field is eliminated, and it is it good. Here, by assuming 1 atm (1013.25 hPa), the atmospheric pressure calculates it.
dry-bulb temperature
absolute humidity
specific volume
percentage humidity
dew-point temperature
kg/kgD.A.
kJ/kgD.A.
m3/kgD.A.
The meaning of each humidity is described well-informed in this after.
Preparation for the description
It explains on the basis of the value measured actually. Please read, after the numerical value measured in the actually place in the field of following dry-bulb temperature and wet bulb temperature or relative humidity with the self is let in, and after "Explain" button is pushed.
For the pressure ( the saturated vapor pressure ) of the steam in containing the water to the limit the, whether there was the steam of the pressure of the what percent at present showed % by the relative humidity. The aerial relative humidity here is %. It becomes 0 %, when it becomes a case in which the water is contained to the limit for 100 %, and when it completely does not contain the water.
This relative humidity is indicated, when it is generally called the humidity. However, the quantity of including water is be same, when the aerial temperature changes, and the value of the relative humidity changes. As the saturated vapor pressure changes on this by the aerial temperature, be.
The aerial absolute humidity here is kg/kgD.A. This shows whether it includes the water of what kg for drying air 1kg. This absolute humidity is spent, when they want to accurately know the mass of the water which is included for the air.
Usually, the volume of 1kg dry air becomes about 0.83m3 at 20 C in 1 atm. The water of weight (kg) over this numerical value will be included for the air in 1m cube in one side. The water of the quantity of surprising so that it may not see it as a water, is included.
The pressure of the vapor which is included for the air is shown. The pressure of the steam which is included for this air is mmHg. The unit is the pressure which corresponds to the Torricelli's making length which is vacuum by the mercury. 760 mmHg is 1 atm, and it becomes that it is broken in 760 by putting on 1013.25 for this value, for the unit of hPa.
This shows the energy which the air has. This aerial enthalpy is kJ/kgD.A. 4.186 KJ becomes 1 kcal. Therefore, it can be converted into the kilo calorie, if it is sent, by dropping below calculated value in 4.186.
For example, it is possible to measure the energy given to the air by the heating, if suction port of the heater and difference of the enthalpy of the outlet and aerial flow rate are obtained. It is an important index, when heating and cooling of greenhouses is considered.
This aerial volume including 1kg wet air is shown. The value of the air here is m3/kg
It is called the saturation. The mass of the possible steam of the water of containing for any air as a steam largest, for the mass ( specific humidity at satulation ) which is included at present is shown at the proportion. This air is %.
Since it appears as a liquid without not dissolving in the air, that it gives the dew in the glass window and that the mist comes out like ( condensation and dew condensation ) and bathroom happens. The possible quantity of the dissolution of the water as a steam in the air decreases, as the temperature lowers. So, the dew is easy to be given at the indifferent part. The fog may instantaneously arise, when the suddenly indifferent air is put in, by opening windows such as the greenhouse. Including water calls the fact of appearing temperature the dew-point temperature by the cooling of the air as it is as a liquid. With that the air in of today is cooled to �A C, the dew condensation is done, and the fog arises.
It puts the numerical value in dry-bulb temperature and wet bulb temperature or relative humidity, and the calculation is possible, when "Calculate" button is pushed.
Copyright (C) 1996 Takehiko Hoshi, Tokai University, Shizuoka JAPAN


Mr. Driller: Drill Till You Drop
Platform: DS
Tags: Puzzle
Developer: Bandai Namco
AKA: Sakutto Hama Reru Hori Hori Action: Mr. Driller (JP)
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You've Got to See How Eataly's Rooftop Restaurant Transformed Itself for Fall
The menu features classic fall favorites and edible cocktails.
If you're currently on the lookout for a New York City rooftop restaurant to dine at this fall, your search has officially come to an end. Eataly's rooftop featuring Serra d'Autunno proves that autumn—not summer—is the perfect time of year for a meal while taking in the view of NYC's iconic skyscrapers.
This particular rooftop restaurant at Eataly's Flatiron location, SERRA by Birreria, changes its vibrant, Instagrammable decor with every season—in the spring it's covered in pink flowers, the winter has a dreamy Alpine scheme—but the fall might be the dreamiest of all. Since September 10, the space has been transformed into an "autumn greenhouse," with just about every inch of the space blanketed in orange, red, and yellow foliage.
BOOK NOW Eataly, NYC; TripAdvisor
Besides a stellar Instagram photo that'll make all of your followers jealous, Serra d'Autunno will also feature cocktails served out of edible cups. Keep an eye out for pumpkin, apple, and pomegranate drinks that will be served in hollowed-out fruit. Think of it as an appetizer to your appetizer!
As if that weren't enough, the rooftop restaurant has a build-your-own cider bar that'll give you all the fall feels. All that's missing is your coziest sweater.
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Attorney makes large donation to unnamed nonprofit
Michelle Casady, San Antonio Express-News
Oct. 14, 2014 Updated: Oct. 15, 2014 11 a.m.
1of4Corpus Christi attorney Thomas J. Henry speaks about his donation of $694,000 to the Nicholas LaHood campaign for Bexar County district attorney during a press conference on Tuesday, Oct. 14, 2014. Show MoreShow Less
2of4Thomas J. Henry supports Nicholas LaHood's campaign for Bexar County district attorney. Henry said he is giving $350,000 to a nonprofit to help identify and prevent child abuse. The recipient does not want to be identified, Henry said.Billy Calzada / San Antonio Express-NewsShow MoreShow Less
3of4Corpus Christi attorney Thomas J. Henry speaks about his donation of $694,000 to the Nicholas LaHood campaign for Bexar County district attorney during a press conference on Tuesday, Oct. 14, 2014.Billy CalzadaShow MoreShow Less
4of4Corpus Christi attorney Thomas J. Henry enters his press conference at which he explained his $694,000 donation to the Nicholas LaHood campaign for Bexar County district attorney on Tuesday, Oct. 14, 2014.Billy CalzadaShow MoreShow Less
SAN ANTONIO — Thomas J. Henry said Tuesday he is giving $350,000 to a nonprofit group that will use the money to identify and prevent child abuse, but the personal-injury attorney declined to name the nonprofit.
"To me, it's a cause, it's a way to reverse a trend," he said. "And the way to reverse this trend is not just through this political process, but it's through education and other mechanisms that I think are very important."
Henry, virtually unknown in local politics, has contributed nearly $694,000 to the political campaign of Nicholas LaHood, who's running for district attorney against incumbent Susan Reed.
In a recent full-page San Antonio Express-News ad, Henry said he is supporting LaHood because Bexar County has "extremely high rates of sexual crimes against children and the District Attorney's office has failed to effectively deal with the problem for over 16 years."
Henry, who said he moved here from Corpus Christi with his wife and children in recent months and enrolled them in school this month, told reporters on Tuesday the issue of child abuse in Bexar County was brought to his attention by his community relations department when he asked staff to look into issues in Bexar County in which he could become involved.
LaHood and Hurd attacks don't ring true
LaHood donor sued for stinginess
The nonprofit grant, detailed on a poster at a news conference, will focus on web-based education and training for 49,000 teachers and 200 nurses and health care workers on how to identify and prevent child abuse.
The $350,000 will be used over three years, with a rollout within 90 days.
"Out of courtesy, I'm not bringing that nonprofit into this political process," he said, adding he promised the director he wouldn't identify the nonprofit. "I want to respect their ability and desire to stay out of politics."
Henry said education combined with effective prosecution of offenders can reverse the "completely unacceptable" trend, which is why he said he's supporting LaHood in the DA's race.
"It's going to take a lot of effort," he said. 'It's going to take, I think, a different leadership."
Reed said she doesn't buy it.
"I don't think he's the least bit genuine," she said of his claims that child-abuse rates motivated his participation in the race. "It's all about trying to buy this office and legitimize himself."
But he doesn't try criminal cases and would never take a referral case from the district attorney, Henry said in combating those claims.
"I don't buy offices. I don't need offices," he said.
mcasady@express-news.net
Twitter: @MichelleCasady
Michelle Casady
Reach Michelle on
Michelle Casady is one of a team of reporters covering crime and breaking news in San Antonio and the surrounding communities. She came to the Express-News in February 2012. For three years prior to that, she covered the breaking news and criminal justice beats in Aggieland for The Bryan-College Station Eagle. She graduated from Texas Tech University in 2008 with a journalism degree and grew up in Alvin, Texas, best known as the hometown of Nolan Ryan.