targets_master.csv

target,name,Species,chembl_id,Unnamed: 4,uniprot_id_selected,pdb_code,class,raw_active_count,raw_inactive_count,cleaned_active_count,cleaned_inactive_count,topu_active_count,topu_inactive_count
5ht3a,Serotonin 3a (5-HT3a) receptor,Homo sapiens,CHEMBL1899,,P46098,8bla,Ion channel,778,2307,772,2289,49,1960
5ht6r,Serotonin 6 (5-HT6) receptor,Homo sapiens,CHEMBL3371,,P50406,8jlz,GPCR,4168,2212,4131,2189,47,1880
aa2ar,Adenosine A2a receptor,Homo sapiens,CHEMBL251,,P29274,3eml,GPCR,5194,6237,5159,6212,127,5080
aa3r,Adenosine A3 receptor,Homo sapiens,CHEMBL256,,P0DMS8,8x16,GPCR,4190,5798,4142,5756,120,4800
abl1,Tyrosine-protein kinase ABL,Homo sapiens,CHEMBL1862,,P00519,2hzi,Kinase,2433,4548,2420,4496,97,3880
ace,Angiotensin-converting enzyme,Homo sapiens,CHEMBL1808,,P12821,3bkl,Protease,581,529,578,529,10,400
aces,Acetylcholinesterase,Homo sapiens,CHEMBL220,,P22303,1e66,Other Enzymes,4701,5907,4575,5797,117,4680
ada17,ADAM17,Homo sapiens,CHEMBL3706,,P78536,2oi0,Protease,1728,877,1728,876,18,720
adrb1,Beta-1 adrenergic receptor,Homo sapiens,CHEMBL213,,P08588,7bu7,GPCR,1408,2964,1384,2920,62,2480
adrb2,Beta-2 adrenergic receptor,Homo sapiens,CHEMBL210,,P07550,3ny8,GPCR,1961,4648,1923,4575,102,4080
akt1,Serine/threonine-protein kinase AKT,Homo sapiens,CHEMBL4282,,P31749,3cqw,Kinase,3126,3744,3120,3706,77,3080
akt2,Serine/threonine-protein kinase AKT2,Homo sapiens,CHEMBL2431,,P31751,3d0e,Kinase,1021,2258,1016,2242,48,1920
ampc,Beta-lactamase,Escherichia coli K-12,CHEMBL2026,,P00811,1l2s,Other Enzymes,170,61861,121,61814,12,480
andr,Androgen Receptor,Homo sapiens,CHEMBL1871,,P10275,2am9,Nuclear Receptor,2502,3433,2492,3402,68,2720
aofb,Monoamine oxidase B,Homo sapiens,CHEMBL2039,,P27338,7p4h,Other Enzymes,3417,3014,3403,2996,68,2720
bace1,Beta-secretase 1,Homo sapiens,CHEMBL4822,,P56817,3l5d,Protease,7195,2809,7158,2786,54,2160
braf,Serine/threonine-protein kinase B-raf,Homo sapiens,CHEMBL5145,,P15056,3d4q,Kinase,4066,2726,4060,2715,58,2320
cac1h,Voltage-gated T-type calcium channel alpha-1H subunit,Homo sapiens,CHEMBL1859,,O95180,9ayh,Ion channel,399,1421,398,1417,27,1080
cah2,Carbonic anhydrase II,Homo sapiens,CHEMBL205,,P00918,1bcd,Other Enzymes,7822,3078,7540,2942,62,2480
cdk2,Cyclin-dependent kinase 2,Homo sapiens,CHEMBL301,,P24941,1h00,Kinase,2133,4403,2125,4358,97,3880
cnr2,Cannabinoid CB2 receptor,Homo sapiens,CHEMBL253,,P34972,5zty,GPCR,6645,3098,6604,3085,55,2200
cp1a2,Cytochrome P450 1A2,Homo sapiens,CHEMBL3356,,P05177,2hi4,Cytochrome P450,1029,22581,1024,22415,136,5440
cp2c9,Cytochrome P450 2C9,Homo sapiens,CHEMBL3397,,P11712,1r9o,Cytochrome P450,1893,24225,1882,24052,119,4760
cp2d6,Cytochrome P450 2D6,Homo sapiens,CHEMBL289,,P10635,4wnt,Cytochrome P450,1891,25216,1884,25028,139,5560
cp3a4,Cytochrome P450 3A4,Homo sapiens,CHEMBL340,,P08684,3nxu,Cytochrome P450,3702,30526,3686,30235,154,6160
csf1r,Macrophage colony stimulating factor receptor,Homo sapiens,CHEMBL1844,,P07333,3krj,Kinase,1884,2059,1867,2048,46,1840
cxcr4,C-X-C chemokine receptor type 4,Homo sapiens,CHEMBL2107,,P61073,3odu,GPCR,919,855,907,853,15,600
dhi1,11-beta-hydroxysteroid dehydrogenase 1,Homo sapiens,CHEMBL4235,,P28845,3frj,Other Enzymes,3295,675,3294,670,14,560
dpp4,Dipeptidyl peptidase IV,Homo sapiens,CHEMBL284,,P27487,2i78,Protease,4009,1483,3875,1437,31,1240
drd2,Dopamine D2 receptor,Homo sapiens,CHEMBL217,,P14416,6cm4,GPCR,7860,5197,7795,5119,113,4520
drd3,Dopamine D3 receptor,Homo sapiens,CHEMBL234,,P35462,3pbl,GPCR,5351,4042,5304,3960,85,3400
dyr,Dihydrofolate reductase,Homo sapiens,CHEMBL202,,P00374,3nxo,Other Enzymes,978,921,975,918,19,760
egfr,Epidermal growth factor receptor erbB1,Homo sapiens,CHEMBL203,,P00533,2rgp,Kinase,7575,7645,7509,7582,153,6120
esr1,Estrogen receptor alpha,Homo sapiens,CHEMBL206,,P03372,1sj0,Nuclear Receptor,3268,5813,3226,5614,112,4480
esr2,Estrogen receptor beta,Homo sapiens,CHEMBL242,,Q92731,2fsz,Nuclear Receptor,2135,2936,2108,2796,56,2240
fa10,Coagulation factor X,Homo sapiens,CHEMBL244,,P00742,3kl6,Protease,5395,2188,5315,2126,43,1720
fak1,Focal adhesion kinase 1,Homo sapiens,CHEMBL2695,,Q05397,3bz3,Kinase,1649,2123,1642,2099,44,1760
fgfr1,Fibroblast growth factor receptor 1,Homo sapiens,CHEMBL3650,,P11362,3c4f,Kinase,2829,3534,2807,3509,77,3080
fnta,Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit,Homo sapiens,CHEMBL2094108,,"P49354, P49356",3e37,Other Enzymes,1745,652,1745,651,12,480
gcr,Glucocorticoid receptor,Homo sapiens,CHEMBL2034,,P04150,3bqd,Nuclear Receptor,2488,2992,2484,2952,56,2240
glcm,Beta-glucocerebrosidase,Homo sapiens,CHEMBL2179,,P04062,2v3f,Other Enzymes,415,12008,410,11966,21,840
hdac2,Histone deacetylase 2,Homo sapiens,CHEMBL1937,,Q92769,3max,Other Enzymes,1995,1767,1978,1758,28,1120
hdac8,Histone deacetylase 8,Homo sapiens,CHEMBL3192,,Q9BY41,3f07,Other Enzymes,2129,1465,2123,1451,29,1160
hivint,Human immunodeficiency virus type 1 integrase,Human immunodeficiency virus 1,CHEMBL3471,,Q7ZJM1,3nf7,Other Enzymes,2275,2462,2254,2447,48,1920
hivpr,Human immunodeficiency virus type 1 protease,Human immunodeficiency virus 1,CHEMBL243,,Q72874,1xl2,Protease,4511,1556,4491,1550,25,1000
hivrt,Human immunodeficiency virus type 1 reverse transcriptase,Human immunodeficiency virus 1,CHEMBL247,,Q72547,3lan,Other Enzymes,4797,3676,4702,3576,75,3000
hmdh,HMG-CoA reductase,Homo sapiens,CHEMBL402,,P04035,3ccw,Other Enzymes,269,1064,261,1058,11,440
hrh3,Histamine H3 receptor,Homo sapiens,CHEMBL264,,Q9Y5N1,7f61,GPCR,4286,3051,4240,3023,65,2600
hxk4,Hexokinase type IV,Homo sapiens,CHEMBL3820,,P35557,3f9m,Other Enzymes,1041,463,1041,463,10,400
igf1r,Insulin-like growth factor I receptor,Homo sapiens,CHEMBL1957,,P08069,2oj9,Kinase,2428,3289,2427,3273,66,2640
inha,Enoyl-[acyl-carrier-protein] reductase,Mycobacterium tuberculosis,CHEMBL1849,,P9WGR1,4trj,Other Enzymes,267,671,261,671,14,560
jak2,Tyrosine-protein kinase JAK2,Homo sapiens,CHEMBL2971,,O60674,3lpb,Kinase,6568,3777,6553,3757,84,3360
kcnh2,HERG,Homo sapiens,CHEMBL240,,Q12809,8zyq,Ion channel,7110,16267,7067,16086,352,14080
kit,Stem cell growth factor receptor,Homo sapiens,CHEMBL1936,,P10721,3g0e,Kinase,1536,2526,1530,2517,53,2120
kpcb,Protein kinase C beta,Homo sapiens,CHEMBL3045,,P05771,2i0e,Kinase,620,1252,616,1235,26,1040
lck,Tyrosine-protein kinase LCK,Homo sapiens,CHEMBL258,,P06239,2of2,Kinase,1943,4375,1937,4346,93,3720
mapk2,MAP kinase-activated protein kinase 2,Homo sapiens,CHEMBL2208,,P49137,3m2w,Kinase,869,2718,868,2700,59,2360
mcr,Mineralocorticoid receptor,Homo sapiens,CHEMBL1994,,P08235,2aa2,Nuclear Receptor,944,490,943,489,10,400
met,Hepatocyte growth factor receptor,Homo sapiens,CHEMBL3717,,P08581,3lq8,Kinase,3784,3622,3777,3597,76,3040
mk01,MAP kinase ERK2,Homo sapiens,CHEMBL4040,,P28482,2ojg,Kinase,3128,18279,3127,18105,68,2720
mk10,c-Jun N-terminal kinase 3,Homo sapiens,CHEMBL2637,,P53779,2zdt,Kinase,1262,1653,1258,1648,37,1480
mk14,MAP kinase p38 alpha,Homo sapiens,CHEMBL260,,Q16539,2qd9,Kinase,4362,4056,4356,4032,86,3440
mmp13,Matrix metalloproteinase 13,Homo sapiens,CHEMBL280,,P45452,830c,Protease,2588,762,2585,763,17,680
mp2k1,Dual specificity mitogen-activated protein kinase kinase 1,Homo sapiens,CHEMBL3587,,Q02750,3eqh,Kinase,889,2043,887,2021,44,1760
nos1,"Nitric-oxide synthase, brain",Rattus norvegicus,CHEMBL3048,,P29476,1qw6,Other Enzymes,567,1261,544,1246,19,760
oprd,Delta opioid receptor,Homo sapiens,CHEMBL236,,P41143,6pt3,GPCR,4321,4824,4265,4771,103,4120
oprk,Kappa opioid receptor,Homo sapiens,CHEMBL237,,P41145,9mql,GPCR,5064,3992,5010,3948,84,3360
oprm,Mu opioid receptor,Homo sapiens,CHEMBL233,,P35372,9mqi,GPCR,5546,5403,5489,5329,113,4520
parp1,Poly [ADP-ribose] polymerase-1,Homo sapiens,CHEMBL3105,,P09874,3l3m,Other Enzymes,3596,952,3589,947,20,800
pde5a,Phosphodiesterase 5A,Homo sapiens,CHEMBL1827,,O76074,1udt,Other Enzymes,1872,1649,1866,1641,34,1360
pgh1,Cyclooxygenase-1,Ovis aries,CHEMBL2949,,P05979,2oyu,Other Enzymes,900,2984,898,2974,63,2520
pgh2,Cyclooxygenase-2,Mus musculus,CHEMBL4321,,Q05769,3ln1,Other Enzymes,462,746,462,743,15,600
plk1,Serine/threonine-protein kinase PLK1,Homo sapiens,CHEMBL3024,,P53350,2owb,Kinase,1253,25981,1252,25947,66,2640
ppara,Peroxisome proliferator-activated receptor alpha,Homo sapiens,CHEMBL239,,Q07869,2p54,Nuclear Receptor,2566,2365,2559,2341,40,1600
ppard,Peroxisome proliferator-activated receptor delta,Homo sapiens,CHEMBL3979,,Q03181,2znp,Nuclear Receptor,1698,2055,1689,2038,35,1400
pparg,Peroxisome proliferator-activated receptor gamma,Homo sapiens,CHEMBL235,,P37231,2gtk,Nuclear Receptor,3990,3996,3979,3971,73,2920
prgr,Progesterone receptor,Homo sapiens,CHEMBL208,,P06401,3kba,Nuclear Receptor,1877,2743,1874,2737,55,2200
ptn1,Protein-tyrosine phosphatase 1B,Homo sapiens,CHEMBL335,,P18031,2azr,Other Enzymes,2377,3377,2375,3352,64,2560
pygm,Muscle glycogen phosphorylase,Oryctolagus cuniculus,CHEMBL4696,,P00489,1c8k,Other Enzymes,149,687,148,685,10,400
pyrd,Dihydroorotate dehydrogenase,Homo sapiens,CHEMBL1966,,Q02127,1d3g,Other Enzymes,1093,1084,1089,1084,25,1000
rock1,Rho-associated protein kinase 1,Homo sapiens,CHEMBL3231,,Q13464,2etr,Kinase,1667,2022,1649,2010,44,1760
rxra,Retinoid X receptor alpha,Homo sapiens,CHEMBL2061,,P19793,1mv9,Nuclear Receptor,610,1066,609,1063,20,800
scn5a,Sodium channel protein type V alpha subunit,Homo sapiens,CHEMBL1980,,Q14524,6lqa,Ion channel,766,2065,764,2061,43,1720
src,Tyrosine-protein kinase SRC,Homo sapiens,CHEMBL267,,P12931,3el8,Kinase,3011,4570,2992,4529,98,3920
tgfr1,TGF-beta receptor type I,Homo sapiens,CHEMBL4439,,P36897,3hmm,Kinase,1129,1030,1127,1028,22,880
thb,Thyroid hormone receptor beta-1,Homo sapiens,CHEMBL1947,,P10828,1q4x,Nuclear Receptor,574,5734,574,5709,20,800
thrb,Thrombin,Homo sapiens,CHEMBL204,,P00734,1ype,Protease,4661,5339,4434,5256,104,4160
trpa1,Transient receptor potential cation channel subfamily A member 1,Homo sapiens,CHEMBL6007,,O75762,6x2j,Ion channel,632,463,631,463,10,400
try1,Trypsin I,Homo sapiens,CHEMBL209,,P07477,2ayw,Protease,1223,817,1165,797,16,640
tysy,Thymidylate synthase,Homo sapiens,CHEMBL1952,,P04818,1syn,Other Enzymes,507,505,505,503,10,400
urok,Urokinase-type plasminogen activator,Homo sapiens,CHEMBL3286,,P00749,1sqt,Protease,856,868,840,848,17,680
vgfr2,Vascular endothelial growth factor receptor 2,Homo sapiens,CHEMBL279,,P35968,2p2i,Kinase,8825,6280,8751,6214,133,5320
wee1,Serine/threonine-protein kinase WEE1,Homo sapiens,CHEMBL5491,,P30291,3biz,Kinase,541,627,541,624,12,480