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135
4d1ea437-263d-4cd9-ac81-b26a8208fc4a
Indications of amnioinfusion includes all of the following, except ?
Prolonged rupture of membranes with oligohydramnios
Variable decelerations
Treatment of late declerations during labour
In decreasing risk of meconium aspiration during labour in patients with thick meconium
2c
multi
Transvaginal amnioinfusion has been extended into three clinical areas (1) treatment of variable or prolonged decelerations, (2) prophylaxis for women with oligohydramnios, as with prolonged ruptured membranes, and (3) attempts to dilute or wash out thick meconium It was concluded that amnioinfusion appeared to be usef...
Gynaecology & Obstetrics
Obstetrics
d2f32a18-5fc9-4aff-9a3d-38196247bec0
Nootropic drug
Rivastigmine
Tacrine
Amantadine
Piracetam
3d
single
Ans. d (Piracetam). (Ref. KD Tripathi, Pharmacology, 4th ed., 481)CEREBROACTIVE DRUGS (COGNITION ENHANCERS)1NootropicPiracetam2Metabolic enhancerDihydrergotaxine,Nicergoline,Piribedil3Cholinergic activatorTacrine4Vasoactive cerebral protectorsPyritinol, Ginko biloba.Educational Points:DRUGUsed in Rx of:Newer cholineste...
Pharmacology
C.N.S
4385f0de-0d91-4c8a-84eb-2c39f04ff980
Best mode of contraception for a newly married lady with rheumatic heart disease:
Oral pills
Norplant
IUCD
Condom
3d
single
Barrier contraceptives (diaphragm/condom) are the ideal contraceptives for patients with medical complications such as heart disease. “The primary advantage of the diaphragm is the almost total absence of risks and medical contraindications.” Combined oral contraceptive pills are contraindicated in a woman with cardia...
Gynaecology & Obstetrics
null
8ca683a1-8f8b-4857-a396-96502c8f5232
Which of the following is the preferred mode of contraception recommended during lactation:
IUCD
DMPA
Progesterone only pills
OCP
2c
single
Medical eligibility criteria (MEC) categories for contraceptive eligibility: 1. A condition for which there is no restriction for the use of the contraceptive method. 2. A condition where the advantages of using the method generally outweigh the theoretical or proven risks. 3. A condition where the theoretical or prove...
Gynaecology & Obstetrics
Puerperium
83e269c7-0494-455f-8a53-1316080f9d43
Total Skin Electron Irradiation is used for the treatment of –
Mycosis Fungoides
Psoriasis
Sezary Syndrome
Brain Metastasis
0a
single
Total Skin Electron Radiation is used primary in patients with Mycosis Fungoides.
Dental
null
2edd50f7-fcf5-4ac8-92dc-8f11dd4c6c71
Normal PCWP with pulmonary oedema is seen in -
Left atrial myxoma
High altitude
Pulmonary vein obstruction
Pulmonary aery obstruction
1b
single
HIGH ALTITUDE PULMONARY EDEMA : Though it remains a topic of intense investigation, multiple studies and reviews over the last several years have helped to elucidate the proposed mechanism of HAPE. The inciting factor of HAPE is the decrease in paial pressure of aerial ).The resultant ) secondary to ) with over-distent...
Medicine
C.V.S
29cb801e-62ab-4b74-b5f9-e17c7ddbf4b1
HLA 27 antigen is associated with all of the following disease except -
Ankylosing spondylitis
Reiter's syndrome
Psoriatic arthorpathy
Rheumatoid arthritis
3d
multi
null
Medicine
null
ceb3213f-a05b-4607-83e4-9959319a79b2
In PT test, the addition of Ca2+ & tissue thromboplastin activates which pathway?
Extrinsic
Intrinsic
Fibrinolytic
Common
0a
single
Ans. (a) ExtrinsicTo PT we add of Ca2+ & tissue thromboplastin which activates extrinsic pathway, while to test for aPTT we add kaolin, silica which activates intrinsic pathway.
Pathology
Bleeding Disorders
c74ffa4d-5f9b-4fac-a259-d69c04996d86
Chinese letter arrangement is seen in: March 2009 & 2011
M.tuberculosis
Corynebnacterium diphtheria
Chlamydia trachomatis
M. leprae
1b
single
Ans. B: Corynebnacterium diphtheria Nonpathogens that resemble Corynebacterium diptheriae in appearance are termed "diptheroids". The arrangement of the bacteria provide a clue to distinguish the pathogen Corynebacterium diptheriae from the nonpathogenic diptheroids. C. diptheriae bacteria form 90 degree angles to one ...
Microbiology
null
84155350-ace5-49f3-be01-bcb8f1a91729
Mechanism of action of Pemetrexed is:-
RNA synthesis inhibitor
Dihydrofolate reductase inhibitor
Dopamine agonist
Topoisomerase inhibitor
1b
single
Dihydrofolate reductase Inhibitors Methotrexate Pralatrexate Pemetrexed PEMETREXED - used in mesothelioma D: Topoisomerase introduces negative coil's and aids in replication IRINOTECAN - topoisomerase Inhibitor
Pharmacology
FMGE 2017
3bfcca38-4513-4eb3-9521-dc89a3a0264c
Dermal leishmaniasis is caused by all except -
L. tropica
L. major
L.aethiopica
None of the above
3d
multi
Ans. is 'd' i.e.None of the above All of the mentioned options cause Dermal leishmaniasis o L. donovani is tha causative agent of dermal leishmaniasis(Post Kala Azar Dermal Leishmaniasis or PKDL). Other three cause cutaneous leishmaniasis. Leishmaniasis, causative agents o L. tropica and L. infantum - Anthroponotic Cut...
Unknown
null
2cfc333b-8186-478b-bb0c-0e9eda6cb70a
Hypothyroidism in pregnancy is least likely associated with
PIH
Recurrent aboions
Polyhydramnios
Preterm labour
2c
single
Ove or symptomatic hypothyroidism is repoed to complicate between 2 and 10 pregnancies per 1000. Clinical/ ove hypothyroidism is confirmed when an abnormally high serum TSH level is accompanied by an abnormally low thyroxine level. Most common cause is Hashimoto thyroiditis Subclinical hypothyroidism is defined by an e...
Gynaecology & Obstetrics
Medical Illness Complicating Pregnancy
25596c3f-b333-4fc6-8d84-18781ad48661
When using low-flow circle absorber techniques, the uptake of nitrous oxide must be considered. In a healthy 70 kg adult the expected uptake of nitrous oxide, with a 70% inspired concentration, after 1.5 hours would be about
1000 ml.min-1
500 ml.min-1
250 ml.min-1
100 ml.min-1
3d
single
uptake of N2O (in mls/min) is equal to 1000 divided by the square root of the time elapsed (in mins) * the time elapsed is 100 minutes. * the square root of this is 10 * 1000 divided by 10 is 100 so the N2O uptake at 100 mins into the case would be about 100mls/min.
Anaesthesia
Preoperative assessment and monitoring in anaesthesia
ac205865-a876-4165-b8a3-4913a9201ec7
Adenoidectomy with grommet inseion is treatment of choice for
Serous otitis media in children
Serous otitis media in adults
Adenoiditis in children
All of the above
0a
multi
Common cause of serous otitis media in children is growth of adenoid; hence treatment aims at removal of cause (adenoidectomy) and drainage of middle ear by grommet. Serous otitis media in adults should arouse suspicion of nasopharyngeal carcinoma and hence the treatment aims at removal of carcinoma Adenoiditis is an a...
ENT
null
351d8b90-d0d4-404f-b6bb-fffa5033f5f5
All of the following are true about Alcoholic hallucinosis except
Seen after 12 - 24 hours of alcohol cessation
Auditory hallucinations are commonly seen
Disturbance of consciousness is present
All are true
2c
multi
Disturbance of consciousness like irrelevant talking is seen in Delirium tremens, not alcoholic hallucinosis.
Psychiatry
null
2acc9fec-ce26-4095-a86e-968cc291c8ed
Which of the following is a histological feature of Whipple's disease -
Infiltration of histocytes in the lamina propria
Granuloma in the lamina
Macrophages with PAS (+) material inside the lamina propria
Eosinophils in the lamina propria
2c
single
null
Medicine
null
6852082e-50a9-4290-9183-c7c9eb83368c
All the following are related to legal responsibility of an insane person except:
Mc Naughten's rule
Durham's rule
Curren's rule
Rule of nine
2c
multi
D i.e. Rule of nine
Forensic Medicine
null
4d35917e-70c0-49d3-8b8d-2dc2f5542789
Following is true about oculocardiac reflex except ?
It is also called aschner phenomenon
It is mediated by occulomotor and vagus nerve
It is characterized by bradycardia following traction on extra-ocular muscles
Reflex is more sensitive in neonates
1b
multi
Ans. is 'b' i.e., It is mediated by occulomotor and vagus nerve Oculocardiac reflex Oculocardiac reflex, is also known as Aschner phenomenon, Aschner reflex, or Aschner-Dagnini reflex, o It is characterized by decrease in pulse rate (bradycardia) associated with traction applied to extraocular muscles and/or compressio...
Ophthalmology
null
0e6633e5-75ab-493d-a897-4755319599af
High inguinal orchidectomy specimen showed teratoma testis with involvement of epididymis; stage is
T1
T2
T3
T4b
0a
single
T0- No evidence of tumour. Tis- Carcinoma in situ T1- Tumour limited to testis and epididymis. Vascular/ lymphatic invasion not present. Tumor may invade tunica albuginea but not tunica vaginalis. T2- Tumour limited to testis and epididymis with vascular/ lymphatic invasion. Or tumor extends through the tunica albugine...
Surgery
Urology
f9b73e70-e83f-489f-abf9-53845b79e1f4
Asymptomatic infant with, Wo TB exposure, He is 3 month old and had taken 3 months of chemoprophylaxis, what is to be done next ?
Test sputum and then decide
Continue for 3 months
Tuberculin test then decide
Immunise with BCG & stop prophylasix
1b
single
Ans. is 'b' i.e., Continue for 3 month (WHO & RNTCP guideline) A child born to mother who was diagnosed to have TB in pregnancy should receive prophylaxis for 6 months, provi ded congenital TB has been ruled out. BCG vaccination can be delayed even if INH chemoprophylaxis is planned
Pediatrics
null
faf135e5-68d8-4ae8-af85-78eb9fa42aa3
Hyperuricemia in von Gierke disease is due to the deficiency of the following enzyme:
Defect in hypoxanthine-guanine phosphoribosyl transferase
Glucose-6-phosphatase
Xanthine oxidase
Adenosine deaminase
1b
single
Purine overproduction and hyperuricemia in von Gierke disease (glucose-6-phosphatase deficiency) occurs secondary to enhanced generation of the PRPP precursor ribose 5-phosphate. The Lesch-Nyhan syndrome, an overproduction hyperuricemia characterized by frequent episodes of uric acid lithiasis and a bizarre syndrome of...
Biochemistry
null
2c97bb3d-610a-4444-9939-f29000e347d8
A baby on examination shows unilateral moro's reflex with positive palmar grasp reflex. The site of lesion is :
C3 - C4
C5 - C6
C8 - C1
C1 - C2
1b
single
Ans. is 'b' C5-C6 Moro's reflex is a neonatal reflex which develops by 28th wk of gestation and disappears by 12 wks of age.Moro reflex is obtained by placing the infant in semi-upright position, then the head is momentarily allowed to fall backward with immediate re-support by the examiner's hand.The child symmetrical...
Pediatrics
Nervous System Disorders
5d128159-fee7-4690-a9bd-0a526ddd28bd
If there is a Gs alpha subunit gain–of–function mutation,this results in:
Decreased cAMP
Decreased IP3
Increased GTPase activity
Increased cAMP
3d
single
null
Pharmacology
null
5532cf1f-6dc0-4607-b8ae-31b5d0c13a1b
Bone resorption is enhanced by
PGD2
PDF2
PGE2
PGI2
2c
single
Bone resorption is increased by prostaglandin E2. Increased PGE2 stimulates binding of RANK ligand to RANK- stimulating osteoclast-causing resorption (REF.Essential of medical pharmacology K D TRIPATHI 6 Edition, Page No - 325)
Pharmacology
Endocrinology
7d36d549-d646-497c-9c82-3a7d02b35fa8
Which one predisposes to Breast cancer-
Adenosis
Fibrosis
Blue domed cysts
Epitheliosis
3d
single
null
Surgery
null
d81aa7a7-ab80-4eff-9701-f738ab330aa8
The following activity increases in DNA in a permissive chromatin:
Methylation of CpG islands
Phosphorylation
Acetylation of histones
Sumoylation
2c
single
Ans. C. Acetylation of histonesEffects of epigenetic modificationMethylation of CpG islands-Repressive chromatinPhosphorylaion of histones-Chromatin condensation (Repressive chromatin) or opening of chromatin (Permissive chromatin)Acetylation of histones-Permissive chromatinSumoylation-Repressive chromatin
Biochemistry
Molecular Genetics
2a3b90ee-b3aa-4a3e-b568-df80518f3eaf
A patient has hyperphosphatemia with short metacarpals and associated cataract. The diagnosis is -
Pseudohypoparathyroidism
Hypophosphatasia
Hyperparathyroidism
Osteomalacia
0a
single
null
Medicine
null
7b15d9e5-327e-4f28-9852-76de867dd62f
Leptospira icterohaemorrhagiae infection is transmitted by the following animals
Rats
Dogs
Birds
Bats
0a
single
(A) Rats # Leptospiral infection Serotype: Icterohaemorrhage Disease: Weil's disease Clinical picture: Fever, jaundice, haemorrhages Animal reservoir: Rat Distribution: Worldwide> Several animals act as carriers for Leptospira.> Rats are particularly important for Leptospira as they are ubiquitous and carry most pathog...
Social & Preventive Medicine
Miscellaneous
aec3c5a3-8aef-4586-99f8-bf41b457e36e
Which of these muscles is not cut in postero lateral thoractomy :
Serratus anterior
Pectoralis major
Latissimus dorsi
Intercostals
1b
single
B. i.e. Pectoralis major
Anatomy
null
eeb519e8-6522-4861-83ae-c908b7478d6b
The best method to confirm the diagnosis of carcinoma cervix is :
Physical examination
Pap smear
Cervical biopsy
Curettage
2c
single
Cervical biopsy
Gynaecology & Obstetrics
null
202fea12-3d43-49eb-8c2c-799baca88a0b
Mucosal lining of fallopian tube secretion for ovum nutrition controlled by -
LH
FSH
Estrogen
Progesterone
3d
multi
Ans. D. ProgesteroneThe secretions of the fallopian tube are a mode of nutrition to the developing zygote till, it reaches uterus and placenta forms.Progesterone increases the secretion of the fallopian tube mucous membrane and. abo causes hyperplasia of the muscular lining of the fallopian tube and makes its peristalt...
Gynaecology & Obstetrics
null
916c8c0f-948f-4204-805c-7d8020a7d287
Mifepristone is used in -
Medical terminations of pregnancy
Breast carcinoma
Prostatic carcinoma
Dysfunctional uterine bleeding
0a
single
Ans. is 'a' i.e., Medical termination of pregnancy Mifepristone Mifepristone is a 19-norsteroid with potent competitive antiprogestational, antiglucocoicod and antiandrogenic action. Mifepriston is a paial agonist and competitive antagonist at both A and B isoforms of progesterone receptors. Uses Termination ofpregnanc...
Pharmacology
null
bd8ff29a-27e6-43b9-85e7-87fa9cc5e35c
Which of the following is not included under Garrod's tetrad
Albinism
Pentosuria
Phenylketonuria
Cystinuria
2c
single
Garrod's tetrad includes Albinism, Pentosuria, Alkaptonuria, Cystinuria.
Biochemistry
null
f0c9f843-a965-48e4-bc02-4bcc5f7c3f99
Auto nephrectomy is seen in
Sickle cell anemia
Renal T.B.
Sarcoidosis
Lymphoma
1b
single
null
Surgery
null
f74f7c56-fa43-42df-a6de-691030d6e744
Gram stained periorbital exudates in severe panophthalmitis with cellulitis in an elderly diabetic shows irregular branching aseptate and broad hyphae. Which of the following is the most likely diagnosis-
Candida
Aspergillus
Pencillium
Apophysomyces species
3d
single
1.Irregular branching aseptate and broad hyphae belong to Zygomycota phylum and cause Zygomycosis. *Zygomycota are aseptate fungi that cause serious infections, primarily in ketoacidotic diabetic patients and cancer patients. 2. Agents of Zygomycosis - - Rhizopus, Mucor, Lichtheimia (Old name: Absidia), Apophysomyces -...
Microbiology
Mycology
3c710831-70c7-4b03-afd0-40014a15ecfc
Gastric infection with H.pylori account for all these adverse events , EXCEPT:
Peptic ulcer disease
Gastric MALT lymphoma
GERD
Gastric adenocarcinoma
2c
multi
Gastric infection with the bacterium H. pylori accounts for Majority of PUD ( Gastric as well as Duodenum) Gastric mucosa-associated lymphoid tissue (MALT) lymphoma Gastric adenocarcinoma. Its association with GERD is not been described. Ref: Harrison-E-18,P-2441
Medicine
null
0ecfce9c-2f90-489c-8f30-0a147b918a48
A female patient Chandani develops chest pain which is not associated with exercise and chest auscultation shows multiple non ejection clicks. The investigation which is used to diagnose the disease is :
Echocardiography
Pyrophosphate scan
Thallium 201 scan
ECG
0a
multi
Answer is A (Echocardiography) The investigation of choice in MVP is echocardiography. Two dimensional echocardiography is paicularly effective in identifying the abnormal position and prolapse of mitral valve leaflets.
Medicine
null
52f0c8dd-7426-494c-9b2a-7a7aa4fa69f9
In Hybrid RNA-DNA, DNA is 5CTTAAG3. The sequence of RNA will be
5CTTAAG3
5CUUAAG3
5GAATTC3
5GAAUUC3
1b
single
The RNA transcript with a 5' to 3' polarity is complementary to the template strand with its 3' to 5' polarity. So, the complementary RNA of template DNA (5'CTTAAG3') will be 3'GAAUUC5' (i.e. 5'CUUAAG3').
Biochemistry
null
126fa52d-9135-4c63-a703-630bc91da827
Mosquitoes decrease as height increases -
Positive correlation
Negative correlation
Bidirectional
Zero
1b
single
Ans. is 'b* i.e., Negative correlation o This is a negative correlation. Le. when height increases the mosquitoes decrease,First read about these two related terms :-o Association - Association may be defined as the concurrence of two variables more often than would be expected by chance. That mean 2 variables exist si...
Social & Preventive Medicine
Data Variables
bbb863d7-b612-448d-bcd2-68ecfb93a351
Which of the following is not associated with pseudomembranous colitis?
Toxin A is responsible for clinical manifestation
Toxin B is responsible for clinical manifestation
Gross blood in stools is common
Summit lesion is early histopathological finding
2c
single
Clostridium difficile produce 5 toxins, toxin A and B are most studied and both causes pseudo membranous colitis. The “Summit” or “volcano” lesions are seen due to mucosal micro ulceration. Diarrhea is soft to watery or mucoid in consistency but never with gross blood
Unknown
null
0af2bdfe-403e-4cb8-8bb0-6960fab85e33
A family consist of husband, wife and children wifes's father has huntington's chorea. Which statment is true -
Chance of getting disease in child is 1:4
Can occur upto age of 50
If wife does not get disease till age 50 children are not affected
Huntingion's chorea is due to point mutation in gene
2c
multi
null
Medicine
null
c736f536-06e8-4d20-9b50-c796d83bb1d9
In low concentration of carbon monoxide (40/) the commonest symptom is :
Nausea
Headache
Muscular weakness
None
3d
multi
D i.e. None
Forensic Medicine
null
60bbb578-24c9-41a3-b05e-54c263482ebc
A 23 year old female presents to the clinic with 5 weeks history of amenorrhea. Pregnancy test done in her was found to be positive and on examination Palmer sign is present. What does Palmer's sign indicate?
Pulsation in lateral fornix
Softening of uterus
Rhythmic contraction of uterus
Bluish colouration of vagina
2c
single
Palmer's sign refers to the regular and rythmic uterine contractions which is elicited during bimanual examination. It is present as early as 4-8 weeks. Osiander's sign refers to the feeling of increased vaginal pulsation felt through the lateral fornices at 8th week of gestation. Jacquemier's sign or Chadwick's sign r...
Gynaecology & Obstetrics
null
b9546186-59e3-441c-bfd0-8a0d41290335
Destructive power of bullet is determined by?
Weight of bullet
Shape of bullet
Size of bullet
Velocity of bullet
3d
single
Ans. is 'd' i.e., Velocity of bullet > 'a' i.e., Weight of bullet o Tissue damage (or destructive power of bullet) is dependent on striking (kinetic) energy of bullet, which is proportional to its mass and square of velocity (KE = 1/2 mv2). So modem bullets are designed to have smaller mass allowing transportation of l...
Forensic Medicine
Injuries by Firearms
e7c5d651-c596-450f-81d3-a70dc108a90d
Poached egg colony on potassium tellurite agar is characteristic of
C. diphtheriae gravis
C. diphtheriae intermedius
C. diphtheriae mitis
C. Jeikeium
2c
single
Daisy head - Gravis Frog's egg colony - Intermedius Poached egg - Mitis.
Microbiology
null
f068f2c0-5eb8-4adc-bfe9-20ebcffed3ed
True about ulcerative colitis are all except
20% end up in colectomy.
The highest risk of UC requiring surgery is in 1st year.
Extra intestinal problems of UC are managed medically
Steroid dependent cases needs surgery.
2c
multi
Ref. Sabiston Textbook of Surgery. Pg. 1340 Extraintestinal manifestations of ulcerative colitis respond to colectomy except Primary sclerosing cholangitis .
Unknown
null
888029a8-0b65-46fe-b3a9-85593457cdc3
True regarding opening of auditory tube in nasopharynx is:
Posterior to inferior nasal concha
Posterior to middle nasal concha
Superior to inferior nasal concha
Inferior to inferior nasal concha
0a
multi
The lateral wall of nasopharynx has pharyngeal opening of the auditory tube, at the level of the inferior nasal concha and 1.2 cm behind it
Anatomy
null
3dd089b6-bf83-48ac-9287-a4497d643469
According to Modified Astler-Collar Classification for colorectal cancer, lymph node invasion with penetration of the entire bowel wall is included in stage:
B1
B2
C1
C2
3d
multi
Modified Duke's (Modified Astler-Collar) classification Stage Description A Confined to the mucosa B1 Paially penetrated the muscularis propria B2 Fully penetrated the muscularis propria C1 Lymph node invasion without penetration of the entire bowel wall C2 Lymph node invasion with penetration of the entire bowel wall ...
Surgery
Large intestine
4fc5d981-f4df-4ff8-942e-f2fcd66ea9ab
Drug of choice for rapid cyclers is
Lithium
Sodium valproate
Carbamazepine
Amitryptaline
1b
single
Sodium valproate is the drug of choice for rapid cyclers. Rapid cyclers has 4 or more than 4 episodes of mania, depression or hypomania in 1 year.
Psychiatry
null
56560da0-cf92-44c7-87fb-c4eb832a2938
True about Tuberculosis HIV patientsa) ↑ Sputum positivityb) INH prophyaxis prevent development of T.Bc) Lack characteristics feature of T.Bd) Highly positive PPD reactione) Atypical radiological features
ce
b
ac
ae
0a
multi
null
Medicine
null
6eeefeb3-73d9-4412-8579-bfa145c28fe2
A 22-year-old woman has an abnormal cervical Pap smear. A biopsy is obtained from a suspicious area on the cervix. The pathology repo says, "There is a loss of the normal orientation of the squamous cells. Atypical cells with wrinkled nuclei and perinuclear halos involve the full thickness of the squamous epithelium. T...
Cervical intraepithelial neoplasia (CIN) I with koilocytic atypia
CIN II with koilocytic atypia
CIN III with koilocytic atypia
Inflammatory atypia secondary to colposcopyaifact
2c
single
The patient has cervical intraepithelial neoplasia (CIN) III with koilocytic atypia secondary to the human papillomavirus. The designation CIN III encompasses both severe dysplasia and carcinoma in situ.Cervical dysplasia is a precursor lesion of cervical squamous cancer. Most cases of cervical dysplasia occur in women...
Gynaecology & Obstetrics
Gynaecological oncology
e11ced88-d7ed-4cd2-b829-a579a4155950
The penicillin G preparation with the longest duration
Benzathine penicillin
Sodium penicillin
Potassium penicillin
Procaine penicillin
0a
single
Penicillin G due to it's rapid tubular secretion, it is very sho acting. It's duration of action is increased with probenecid which compete with penicillin at tubular pump. Procaine penicillin G and benzathine penicillin G are administered IM and serve as depot forms. They are slowly absorbed into the circulation and p...
Pharmacology
Cell Wall Synthesis Inhibitors
5f97bcfa-b6bd-4e0e-9eb3-993cf7c7161f
Which viral infection always causes clinical disease in human beings-
Rubella
Poliomyelitis
Measles
Chicken pox
2c
single
Rubella unfections are in fact subclinical.This represents the one of the major difference between measles and rubella(Ref.PARK'S TEXTBOOK OF PREVENTIVE AND SOCIAL MEDICINE 21st Edition page no.136)
Social & Preventive Medicine
Communicable diseases
667cb468-17a9-4059-87e8-45c64521582a
Hyperextensibility with normal elastic recoil is a feature of -
Ehlers Danlos syndrome
Pseudoxanthoma elasticum
Cutis laxa
Scleroderma
0a
single
Ans. is 'a' i.e., Ehlers Danlos syndrome Ehlers - Panlos syndrome (EPS)Ehler's danlos syndrome comprise a clinically and genetically heterogenous group of disorder that result from some defect in the synthesis or structure of fibrillar collagen.The basic abnormality in Ehler9s Danlos syndrome (EDS) is some defect in th...
Medicine
Disorder of Metabolism & Connective Tissue
116927cb-b3d1-4913-ac37-95a7cb60fa76
Subcoical dementia is seen in all Except:
Parkinsonism
Alzheimers disease
Wilsons disease
Huntingtons chorea
1b
multi
DEMENTIA SUBCOICAL COICAL 1 Characteristic Parkinson disease Huntington disease Wilson 's disease spinocerebellar degeneration coicobasal degeneration normal pressure hydrocephalus Alzheimer Vascular Frontotemporal Lewy Body Dementia 2 Pathology* Prominent changes in striatum , thalamus Prominent changes in coical asso...
Psychiatry
All India exam
6e4c805a-c388-47b7-bd34-b8b2c661ebb8
A patient meets with an accident with resultant transection of the pituitary stalk; what will NOT occur-
Diabetes mellitus
Diabetes insipidus
Hyperprolactinemia
Hypothyroidism
0a
single
diabetes mellitus is a multiorgan disorder due to various genetic and environmental factors( Harrison 17 pg 2275)
Medicine
Endocrinology
f8e47e63-2597-4fd6-a399-8966566f4726
Bone scan in multiple myeloma shows-:
Hot spot
Cold spot
Diffusely increased uptake
Diffusely decreased uptake
1b
single
B i.e. Cold spot
Radiology
null
9975714d-30eb-4d33-b81b-efef1e7e5547
Integrated management of neonatal and childhood illness includes all except:
Malaria
Respiratory infections
Diarrhea
Tuberculosis
3d
multi
Integrated management of neonatal and childhood (IMNCI) illnesses: 1. Diarrhea. 2. Measles. 3. Pneumonia. 4. Malaria. 5. Severe malnutrition and nutritional counseling.
Social & Preventive Medicine
Other NHPs
4c7e6a27-9784-4e90-ab2e-3016d5447710
The dose of betamethasone in prenatal to prevent respiratory distress syndrome is -
6 mg
12 mg every 24 hours
6 mg every 12 hours
4 mg sta
1b
single
Ans. is 'b' i.e., 12 mg every 24 hours
Pediatrics
null
9c3cc383-0ff9-47ae-bc0d-0eac88abe58c
Which of the following is NOT a Calcium channel blocker
Verapamil
Pirenzepine
Felodipine
Nitrendipine
1b
single
Ans. is 'b' i.e., Pirenzepine Pirenzepine is a selective M1 AntagonistCalcium channel blockers.Phenyl alkylamine - VerapamilBenzodiazepine -DiltiazemDihydropyridines - Nifedipine, Felodipine, Amlodipine, Nitrendipine, Nimodipine, Lacidipine More questions on calcium channel blocker -Only voltage sensitive L type channe...
Pharmacology
Anti-Hypertensive
608ba1f2-a6ab-4df4-83bf-cb80edd0f7d7
True statement regarding migraine in pregnancy is:
Ketorolac is preferred
NSAIDs are first line drugs
Improved symptoms with pregnancy
Sumatriptan preferred over chlorpromazine
1b
multi
Ans: (b) NSAIDs are first line drugsRef: Harrison's Principles of Internal Medicine, 19th edition, Page 2592Treatment of Acute MigraineNSAIDsNaproxen, lbuprofen,Tolfenamic acid Diclofenac, Acetominophen5-HT1 Receptor AgonistsOral: Ergotamine, Naratriptan, Rizatriptan, Sumatriptan, Frovatriptan, Almotriptan, Eletriptan,...
Medicine
Blood
5c740686-f4e0-4508-a3d0-03534a146d5d
Diplopia is not a presenting feature in -
Manifest squint
Paralytic squint
Latent squint
Anisometropia
2c
single
Paralytic squint (a type of manifest squint) is the most common cause of diplopia. Anisometropia can also cause diplopia. Latent squint and concomitant squint do not cause diplopia.
Ophthalmology
null
41335c67-0d89-459a-8603-0cbe519c7e95
Phase 4 clinical trial also called as
Therapeutic confirmation
Post marketing surveillance
Therapeutic exploration and dose ranging
Human pharmacology and safety
1b
multi
Phase IV: Postmarketing surveillance/ studies After the drug has been marketed for general use, practicing physicians are identified through whom data are collected on a structured proforma about the efficacy, acceptability and adverse effects of the drug. Uncommon/idiosyncratic adverse effects, or those that occur onl...
Pharmacology
General pharmacology
fb5c5235-8a93-4b8d-8263-9d12bc16dd80
Gynecomastia is seen in :
Secondary syphilis
Tuberculoid leprosy
HIV
Klinefelter's syndrome
3d
single
Features of Klinefelter&;s syndromemale phenotypeGynaecomastiaSterilityPenis is small or normal in sizeVoice may be high pitchedeunuchoid appearance* Gynaecomastia may be noted in lepromatous leprosySHAW&;S TEXTBOOK OF GYNAECOLOGY, Pg no:112,15th edition
Gynaecology & Obstetrics
Sexuality and intersexuality
85c03011-5ef1-4401-8ba8-d5855b279413
Preservative added in DPT vaccine is -
Zinc phosphate
Aluminium phosphate
MgSO4
ZnSO4
1b
single
Page 162 Park&;s textbook of Preventive and social medicine 23rd edition DPT vaccine provides immunity against diphtheria peussis and tetanus Peusis component in the DPT vaccine enhance the potency of diphtheria toxoid There are two types of DPT vaccine -plain and adsorbed Adsorption is usually carried out on a mineral...
Social & Preventive Medicine
Communicable diseases
ef6c5b0e-2ff8-4281-bb33-c909e405feff
Prothrombin activator complex is made of
Factor Xa, Va, VIIIa
Factor Va, VIIa, Platelet Phospholipids
Factor Xa, VIIIa, Tissue Phospholipids
Factor Xa, Va, Platelet Phospholipids
3d
single
Activated Factor X combines with Factor V and platelet or tissue phospholipids to form the complex called prothrombin activator. Reference: Guyton Physiology; 13th ed; Page: 488
Physiology
General physiology
7cb6a989-1a97-4478-9d51-540fff5ae779
A patient of RHD developed infective endocarditis after dental extraction. Most likely organism causing this is
Streptococcus viridans
Streptococcus pneumoiae
Streptococcus pyogenes
Staphylococcus aureus
0a
single
Streptococcus viridans is a group which normally resides in the mouth and upper respiratory tract and is alpha hemolytic. In persons with pre-existing cardiac lesions, they may cause bacterial endocarditis, Streptococcus sanguis being most often responsible. Following the tooth extraction or dental procedures, they cau...
Microbiology
Bacteriology
f6b1fa96-7863-4d7e-8eea-a510799c1965
Retinoblastoma gene is located on?
Chromosome 6
Chromosome 9
Chromosome 13
Chromosome 2l
2c
single
Robbins basic pathology 6th edition. Chapter Neoplasia. Pge no. 286. Retinoblastoma gene is located on chromosome no. 13.
Pathology
General pathology
902cc19e-8651-49c4-9959-b193994e6c77
Durg of choice for chemoprophylaxis of plague -
Erythromycin
Cotrimoxazole
Tetracycline
Sulfadiazine
2c
single
Drug of choice for chemoprophylaxis of plague is tetracycline. For adults, the dose is 500 mg 6 hourly for 5 days A cheaper alternative is sulfonamide, 2 to 3 gm daily for 5 to 7 days. Ref: PARK&;S TEXTBOOK OF PREVENTIVE AND SOCIAL MEDICINE 23rd edition pg: 296
Social & Preventive Medicine
Communicable diseases
7790104d-e5ee-4da9-8472-1a1e99f9fe67
Regional lymph nodes are involved in which of these -
Ewing sarcoma
Osteosarcoma
Adamantinoma
Synovial cell sarcoma
3d
single
Usually, the sarcomas do not metastasize to the lymph nodes. Sarcomas which metastasize to lymphatics are Rhabdomyosarcoma           Clear cell sarcoma        Epithelial sarcoma Malignant fibrous histiosarcoma Angiosarcoma Synovial cell sarcoma Lymphosarcoma
Orthopaedics
null
1c326add-8cbf-429a-a36a-c332ca032285
A group of elementary school-age children meet for a birthday party, and in the next few days, about half of them experience a mild upper respiratory illness, with sore throat and runny nose. One family gets laboratory work done and finds that Chlamydia pneumoniae (TWAR) is involved. Which of the following procedures w...
Cold agglutinin test
Culture of respiratory secretions in HeLa cells after centrifugation of the inoculated tubes
Culture of respiratory secretions on monkey kidney cells
Detection of specific antigen in urine
1b
single
Atypical pneumonia" is an old classification used for respiratory disease that is not lobar and is not "typical." That is, it does not include pneumonia caused by pneumococcus, Klebsiella, Haemophilus, or b-hemolytic streptococci that results in a typical lobular infiltrate. In recent years, the atypical pneumonias hav...
Microbiology
Bacteria
bacb2702-7822-4e0c-b6aa-20a19ff4b95b
Schistosomiasis is an exmple of:
Meta-zoonoses
Cyclo-zoonoses
Direct-zoonoses
Sporo-zoonoses
0a
single
Ans. a. Meta-zoonoses
Microbiology
null
9e77e4af-ef6d-437b-9f8f-321c27b95ccb
The Maximum concentration of potassium delivered central vein is?
20 mmol/L
40 mmol/L
60 mmol/L
100 mmol/L
2c
single
Answer- C. 60 mmol/LMaximum concentration possible delivered central vein = 60 mmo/l
Medicine
null
7b241424-1768-4cd6-acc9-0be9d16ee9f6
The position of hand during application of POP cast for fracture scaphoid has been clasically described as
Boat shaped position
Clenched fist position
Tumbler holding position
Boxing position
2c
multi
In Scaphoid fracture, the cast is applied to maintain dorsi-flexion of the wrist area. This is called the Glass holding position/Tumbler holding position. In Colle&;s fracture, POP is applied to keep it in palmar flexion and ulnar detion. This is called Shake hand position. ref : maheswari 9th ed
Anatomy
null
509cfe11-8ef9-4e54-b577-bf87d5cd8934
What is the most common site of brain Hemorrhage?
Putamen
Internal capsule
Ventral pons
Cerebellum
0a
single
The MC site of brain hemorrhage is Putamen. Intraparenchymal hemorrhage is most lethal and has a moality rate of 40%. investigation of choice is NCCT. Hypeensive ICH usually results from spontaneous rupture of a small penetrating aery deep in the brain. The most common sites are the basal ganglia (especially the putame...
Medicine
Brain Hemorrhage
50c44ad0-cf50-426b-b406-05a36b42816d
Flag sign is seen in:
Kwashiorkor
Marasmus
Pellagra
Hypothyroidism
0a
single
In Kwashiorkor hair is thin, dry, brittle, easily pluckable, sparse & devoid of their normal sheen. It becomes straight and hypopigmented. The colour of the hair that grows during the period of nutritional deprivation appears reddish brown. During the phase of better nutrition, the growing pa of the hair gets appropria...
Pediatrics
null
76912c0b-d172-4af6-8b30-0d9649124dcf
The rk39 antigen is used in the diagnosis of:
Tuberculosis
Trypanosomiasis
Toxoplasmosis
Kala azar
3d
single
Ans. D. Kala azara. k-39 antigen is a 39-amino acid residue encoded by a kinesin-related gene in the amastigotes of Leishmania causing Kala azar.b. Anti-k39 antibodies are secreted into various body fluids such as urine and sputum along with blood, and have been shown to be useful in the diagnosis of VL.c. Enzyme-linke...
Microbiology
Parasitology
1e34301f-a6d1-4187-88ce-b4fe394b4cf3
Rule of Hasse is used to determine :
The age of fetus
Height of an adult
Race of a person
Identification
0a
single
Ans. is a i.e. The age of fetus Hasse's rule is employed in calculating the age of fetus by its length During the first five months of pregnancy, the length in cms is square of the age in months i.e. Length in cms = (Age in months)? Age in months = Qlength in cms During second five months of pregnancy, length in cms di...
Gynaecology & Obstetrics
null
f1036301-731b-414a-ba4a-7f52e85f77c0
About glycolysis true is:
Occurs in mitochondria
Complete breakdown of glucose
Conversion of glucose to 3C units
3 ATPs are used in anaerobic pathway
2c
multi
Ans. C. Conversion of Glucose to 3C units(Ref. Harper 3 He page 157)Option a. Glycolysis occur in cytosolOption b. Complete breakdown of Glucose happens when Pyruvate formed by Glycolysis undergo Pyruvate Dehydrogenase reaction, followed by TCA Cycle.Option d. In anaerobic GlycolysisNumber of ATPs produced is 4Number o...
Biochemistry
Carbohydrates
36d336e1-82ac-4d25-8b83-a2bcb2783fba
Sclera is thinnest at
Near the optic nerve
At inseion of the extra ocular muscles
Around the limbus
Nasally
1b
multi
(Refer: AK Khurana Comprehensive Ophthalmology, 6th edition, pg no. 140) The thickest pa of the sclera - Near the optic nerve (at the posterior pole)The thinnest pa of the sclera- Near the inseion of extraocular muscles ref khurana 6th edition pg 566
Ophthalmology
Cornea and sclera
a1c669ff-8eae-4a66-840c-b157c7124bf1
All are pneumatization patterns ot sphenoid sinus except:
Pre sellar
Post sellar
Concha bullosa
Conchal
2c
multi
Three types of sphenoid sinus pneumatization patterns have been found.Pneumatisation patterns depend on the position of thr sinus in relation to the sella turcica. Ref Dhingra 6/e,p 188.
ENT
Nose and paranasal sinuses
58d0146c-c269-4fa2-a3c1-afd1e248eae5
Lacquer cracks in pathological myopia is due to breaks in
Retinal pigment epithelium
Bruch's membrane
Outer plexiform layer
Inner plexiform layer
1b
single
Lacquer cracks in pathological myopia is due to breaks in Bruch's membrane.
Ophthalmology
null
7fd0bdd9-cc48-4e70-aaca-1dee63374b1f
Frontal lobe syndrome is characterised by all except
Slowed thinking
Decreased curiosity
Social withdrawal
Good Judgement
3d
multi
The frontal lobe syndrome, consists of poor judgement, slowed thinking, decreased curiosity, social withdrawal, and irritability. The frontal lobe is the region that determines how the brain acts on its knowledge. Frontal lobe injury Impairs the executive function: motivation, attention, and sequencing of actions. Apha...
Physiology
Nervous system
00c36071-3fa9-417d-819b-d8cfac97db5a
Which is associated with Ted risk of Thromboembolism in a normal pregnancy :
|ed progesterone level
|ed production of clotting factors by liver
Change in blood viscosity
|ed antithrombin III
1b
single
Ans. is b i.e. |ed production of clotting factors by liver Pulmonary thromboembolism is a rare complication of pregnancy but is a significant cause of maternal morbidity and moality. All of us have studied in surgery - Virchow's Traid i.e. factors associated with thromboembolism viz : Endothelial injury Stasis Increase...
Gynaecology & Obstetrics
null
9fe3725e-627c-48f1-a567-639b970400f2
SAMPLE history involves all except :
Allergies
Personal history
Last oral intake and menstruation.
Past medical history.
1b
multi
SAMPLE history is a mnemonic acronym used in assessment of a person/patient in field of emergency medicine by police officers and EMTs, often used in conjunction with the vital signs. AMPLE history is a derivative of SAMPLE history which places a greater emphasis on a persons medical history. Mnemonic goes as follows: ...
Medicine
null
e7f55c86-94cd-4571-b2b5-ff9392f2b93a
All are used in treatment of amoebic liver abscess except -
Diloxanide furoate
Chloroquine
Metronidazole
Emetine
0a
multi
Ans. is 'a' i.e., Diloxanide furoate Diloxanide furoate is a highly effective luminal amoebicide but has no systemic antiamoebic activity. This is because the furoate ester is hydrolysed in the intestine and the released diloxanide is absorbed. Diloxanide is a weaker amoebicide then its furoate ester and no systemic an...
Surgery
null
29a3d693-c655-403e-b37e-c3ea7d78e995
A study is conducted to assess the risk of acquiring a severely debilitating disease over a 1- year study period. Only males are susceptible to the disease, which can be diagnosed using 4 basic clinical criteria. In a population of 100,000 people. 10 men met all the criteria. An additional 90 men demonstrated mild symp...
0.01%
0.02%
0.20%
0.40%
1b
multi
null
Social & Preventive Medicine
null
4fe30182-9ca8-4dea-a3e4-033a6ef813ac
Cork-screw appearance of esophagus:
Achalasia cardia
Cancer esophagus
Schatzki ring
DES
3d
single
Ans. (d) DESRef: Bailey and Love 26th edition, Page 1017 Diffuse Esophageal Spasm:* Hyper Motility disorder characterized by chest pain and dysphagia* Most common finding is cork screw esophagus in lower 2/3rd esophagus commonly.* Medical treatment is primary: Calcium channel blockers, vasodilators, endoscopic dilatati...
Surgery
Oesophagus
331c2d84-62f4-4e69-b6e7-f5f329ff2061
A young man presented with a lesion in his hand which resembles a 'bull's eye'. He recalled that he was bitten by 'something' last evening when he went outdoor. If you are suspecting Lyme's disease in this patient, what is the causative organism responsible:
Borrelia parkeri
Borellia burgdorferi
Borrelia recurrentis
Borrelia hermsii
1b
multi
Lyme disease, the most common ahropod-borne disease in the United States, is primarily caused by the bacterium Borrelia burgdorferi. It is a spirochete, helically shaped, motile. Lyme disease is characterized by three clinical stages. The first stage is characterized by erythema chronicum migrans (ECM), an erythematous...
Microbiology
null
37bffc64-431b-42e1-9272-52f776b69aaf
A 3 year old child can do all, except –
Eat with a spoon
Climb stairs running
Walk properly
Vocabulary of 20–100 words
1b
multi
Important milestones of a 3 years child Rides tricycle                                                              Stands momentarily on one foot.                            Draws a circle.                                                             Can dress or undress himself completely               Builds tower o...
Pediatrics
null
fbba6154-3628-4dcc-ae3a-e653a476cb88
A 15 year old boy presents to you with history of fever, altered sensorium and purpuric rash for two days. On examination, the patient is found stuporous. He has a BP of 90/60 mmHg and extensive palpable purpura over the legs. Which of he following would be the most appropriate initial choice of antibiotic
Vancomycin
Pencilline G
Ciprofloxacin
Gentamicin
1b
single
null
Medicine
null
199cbba9-6163-4e62-9a16-815e433a11ea
Liver transplantation was first done by ?
Starzl
Huggins
Carrel
Christian Benard
0a
single
Ans. is 'a' i.e., Starzl The first human liver transplant was performed in 1963 by Dr. Thomas Starzl.
Surgery
null
0189b26e-cfd6-490a-9195-030287845b23
A 45 year old patient presents with history of fever, night sweats and weight loss. On X-ray, a mass in apical lobe of lung is seen. On histopathology, it was found to have caseous necrosis. What is the likely underlying process involved -
Enzymatic degeneration
Hypersensitivity reaction with modified macrophages, lymphocytes and giant cells
Acute decrease in blood supply
Decreased supply of growth factors
1b
single
. Hypersensitivity reaction with modified macrophages, lymphocytes and giant cells
Pathology
null
db685621-a007-47bc-b117-db6ff71b4c06
Methotrexate is often used as a chemotherapeutic agent to treat patients with leukemia. This drug is effective because it inhibits cells in which pa of the cell cycle
G1 phase
S phase
G2 phase
M phase
1b
single
Methotrexate inhibits the synthesis of deoxythymidine by preventing the regeneration of THF by inhibiting the enzyme DHFR. Inhibiting the synthesis of deoxythymidylate prevents the cell from synthesizing its DNA. DNA synthesis occurs exclusively during S phase of the cell cycle. Ref:- KD Tripathi
Pharmacology
Chemotherapy
dfa666c3-0716-4d39-9bb9-4feeb05f8892
False regarding gouty arthritis is -
Synovial fluid analysis is diagnostic
Allopurinol is the treatment of choice in acute gout
Arthritis occurs after long attack of hyperuricemia
Level of uric acid in blood and severity of gout has good correlation
1b
multi
null
Medicine
null
0ed8b822-99f6-4387-842f-5c74c512956c
A 5-day-old term male neonate presents with delayed passage of meconium, abdominal distension and bilious vomiting. Barium enema and intestinal biopsy findings are shown below. What is the diagnosis?
Congenital aganglionic megacolon
Hypertrophic pyloric stenosis
Cystic fibrosis
Intestinal malrotation
0a
single
a. Congenital aganglionic megacolonBa enema shows narrow distal segment with dilated proximal segment of intestineIntestinal biopsy shows hypertrophied nerve bundles between muscular layer & submucosa
Pediatrics
Gastro Intestinal System
3fe3fed0-6ce9-474b-8768-3b55faad2515
A patient presents with cough with expectoration. Diagnosis of farmers lung is suspected. True statement regarding this condition:
May to June seasonal
Persistent cough with expectoration
X-ray features upper lobe predominant in chronic HP
Pleural effusions are common
2c
multi
Ans: (c) X-ray features upper lobe predominant in chronic HPRef: Fishman's Pulmonary Disease and Disorders, 5th edition, Chapter 58Farmer's LungResults from exposure to moldy hay containing spores of Thermophilic Actinomycetes that produce a hypersensitivity pneumonitisMost cases of farmer's lung disease occur in cold,...
Medicine
Respiratory
cc6a8570-8c11-4033-8625-4944265f389e
All are features of reversible injury of cell, except-
Blebs
Amorphous densities in mitochondrial matrix
Loss of microvlli
Cellular swelling
1b
multi
Ans. is 'b' i.e., Amorphous densities in mitochondrial matrixFormation of amorphous densities in the mitochondrial matrix is a feature of irreversible injury and not reversible injury.Features of reversible cell injuryFeatures of irreversible cell injuryo Cellular swellingo Loss of microvillio Formation of cytoplasmic ...
Unknown
null
910f4344-c7ce-4e71-90d0-6d6dc3b56029
Inferior pancreaticoduodenal aery is a branch of which of the following aery?
Splenic aery
Left gastric aery
Gastroduodenal aery
Superior mesenteric aery
3d
single
Inferior pancreaticoduodenal aery is a branch of superior mesenteric aery. It supplies the pancreas and adjoining pa of the duodenum. Its anterior and posterior branches anastomose with the branches of superior pancreaticoduodenal aery. This anastomosis is the only communication between the aeries of foregut and midgut...
Anatomy
All India exam
03c0531f-96c9-45a2-a3b3-c25d4e9d46ee
All of the following are used in treatment of pneumocystis carinii except
Pentamidine
Dapsone
Cotrimoxazole
Fluoroquinolones
3d
multi
The treatment of choice for PCP is trimethoprim-sulfamethoxazole (TMP-SMX), given either IV or PO for 14-21 days. Sulfadiazine plus pyrimethamine, an oral regimen more often used for treatment of toxoplasmosis, also is highly effective. Dapsone plus pyrimethamine or dapsone plus trimethoprim also can be used. Intraveno...
Anatomy
Respiratory system