pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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25,960,134 | Does phenotype-dependent alteration of pathways and networks reveal a pure synergistic mechanism for compounds treating mouse cerebral ischemia? | {
"contexts": [
"Our previous studies have showed that ursodeoxycholic acid (UA) and jasminoidin (JA) effectively reduce cerebral infarct volume in mice. In this study we explored the pure synergistic mechanism of these compounds in treatment of mouse cerebral ischemia, which was defined as synergistic actions sp... | The pure synergism between UA and JA underlies 10 new core pathways and 3 new core functions, which are involved in inflammation, immune responses, apoptosis and nervous system development. | yes |
25,959,979 | Do pallidal and caudate volumes correlate with walking function in multiple sclerosis? | {
"contexts": [
"Walking dysfunction is common in multiple sclerosis (MS). The thalamus and basal ganglia seemingly have important associations with walking performance. The contribution of these subcortical gray matter (SGM) structures for walking dysfunction is poorly understood in MS.",
"This study examine... | We provide novel evidence of possible SGM structures, particularly the pallidum and perhaps caudate, as correlates of walking performance in MS. | yes |
25,981,460 | Do mathematical optimization of contrast concentration for T1-weighted spoiled gradient echo imaging? | {
"contexts": [
"To develop and validate closed form mathematical expressions that predict the optimal contrast agent concentration for the maximum T1-weighted spoiled gradient echo (SGRE) signal.",
"Gadolinium and iron-based contrast agents can have significant transverse relaxivity that leads to signal drop... | This work provides validated mathematical expressions for contrast enhanced T1-weighted SGRE imaging and may provide guidance for contrast dosing and injection protocols, as well as for novel pulse sequence design. | yes |
25,979,109 | Is the guanylate cyclase-C signaling pathway down-regulated in inflammatory bowel disease? | {
"contexts": [
"Activation of membrane receptor guanylate cyclase-C (GC-C) is implicated in gastrointestinal fluid and electrolyte balance, preservation of intestinal barrier integrity, anti-trophic effects and inhibition of pain sensation. To evaluate GC-C signaling, we examined the regulation of GC-C (GUCY2C/G... | GUCA2A, GUCA2B and GUCY2C as well as several steps of the GC-C signaling pathway are down-regulated in IBD. This may have implications in IBD pathogenesis. | yes |
25,971,746 | Does nF-κB induce miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma? | {
"contexts": [
"Inflammatory cytokines and transforming growth factor-β (TGF-β) are mutually inhibitory. However, hyperactivation of nuclear factor-κB (NF-κB) and TGF-β signaling both emerge in glioblastoma. Here, we report microRNA-148a (miR-148a) overexpression in glioblastoma and that miR-148a directly suppre... | These findings uncover a plausible mechanism for NF-κB-sustained TGF-β/Smad activation via miR-148a in glioblastoma, and may suggest a new target for clinical intervention in human cancer. | yes |
25,987,316 | Does post-repolarization refractoriness increase vulnerability to block and initiation of reentrant impulses in heterogeneous infarcted myocardium? | {
"contexts": [
"Myocardial infarction causes remodeling of the tissue structure and the density and kinetics of several ion channels in the cell membrane. Heterogeneities in refractory period (ERP) have been shown to occur in the infarct border zone and have been proposed to lead to initiation of arrhythmias. Th... | (1) ERP transitions at the NZ-IZ border are abrupt as a consequence of PRR; (2) PRR increases the vulnerability to block and initiation of reentrant impulses in heterogeneous myocardium; (3) V1V2/V2T1 relationships measured at ERP heterogeneities in the computer model and in experimental canine infarcts are not consist... | yes |
25,983,276 | Does hydrogen inhalation protect against acute lung injury induced by hemorrhagic shock and resuscitation? | {
"contexts": [
"Hemorrhagic shock followed by fluid resuscitation (HS/R) triggers an inflammatory response and causes pulmonary inflammation that can lead to acute lung injury (ALI). Hydrogen, a therapeutic gas, has potent cytoprotective, antiinflammatory, and antioxidant effects. This study examined the effects... | Hydrogen, administered through inhalation, may exert potent therapeutic effects against ALI induced by HS/R and attenuate the activation of inflammatory cascades. | yes |
25,966,751 | Does carbon Monoxide Releasing Molecule accelerate Reendothelialization after Carotid Artery Balloon Injury in Rat? | {
"contexts": [
"This study was aimed to investigate the effects of carbon monoxide releasing molecule (CORM-2), a novel carbon monoxide carrier, on the reendothelialization of carotid artery in rat endothelial denudation model.",
"Male rats subjected to carotid artery balloon injury were treated with CORM-2,... | CORM-2 could promote endothelial repair, and inhibit neointima formation after carotid artery balloon injury, which might be associated with the function changes of HUVECs regulated by PI3K/Akt/eNOS pathway. | yes |
25,966,752 | Is high Physical Activity Associated with an Improved Lipid Profile and Resting Heart Rate among Healthy Middle-aged Chinese People? | {
"contexts": [
"To investigate the effects of physical activity (PA) on dyslipidemia and elevated resting heart rate (RHR) in a large-scale cross-sectional study in China.",
"We recruited community-based individuals who were 40-60 years old using a cluster sampling method. The PA levels of the participants w... | Our data suggested that substantial health benefits (related to dyslipidemia and elevated RHR) occurred at higher intensity PA, with greater energy consumption, in middle-aged Chinese people, and particularly in men. | yes |
25,966,753 | Does grape Seed Proanthocyanidin Extract alleviate Arsenic-induced Oxidative Reproductive Toxicity in Male Mice? | {
"contexts": [
"To determine the ability of grape seed proanthocyanidin extract (GSPE) in alleviating arsenic-induced reproductive toxicity.",
"Sixty male Kunming mice received the following treatments by gavage: normal saline solution (control); arsenic trioxide (ATO; 4 mg/kg); GSPE (400 mg/kg); ATO+GSPE (1... | GSPE alleviates oxidative stress damage in mouse testis by activating Nrf2 signaling, thus counteracting arsenic-induced reproductive toxicity. | yes |
25,960,009 | Does subclinical hypothyroidism in combination with vitamin D deficiency increase the risk of impaired left ventricular diastolic function? | {
"contexts": [
"Subclinical hypothyroidism and vitamin D deficiency are common. The diastolic function of patients with both subclinical hypothyroidism and vitamin D deficiency remains unknown. This study aimed to investigate diastolic dysfunction in patients with both subclinical hypothyroidism and vitamin D de... | The coexistence of subclinical hypothyroidism with vitamin D deficiency can lead to further deterioration in the LV diastolic function via the regulation of intracellular calcium and induction of inflammatory activity. Therefore, close follow-up of the diastolic functions of these patients could be beneficial. | yes |
25,985,094 | Does imaging correlate of Memory and Concussion History in Retired National Football League Athletes? | {
"contexts": [
"To our knowledge, this is the first study to show an association between concussion, cognition, and anatomical structural brain changes across the age spectrum in former National Football League athletes.",
"To assess the relationship of hippocampal volume, memory performance, and the influen... | Prior concussion that results in loss of consciousness is a risk factor for increased hippocampal atrophy and the development of MCI. In individuals with MCI, hippocampal volume loss appears greater among those with a history of concussion. | yes |
25,984,322 | Does insulin-like growth factor 1 myocardial expression decrease in chronic alcohol consumption? | {
"contexts": [
"Alcoholic cardiomyopathy (CMP) is one of the major complications of chronic excessive alcohol consumption. The pathogenic mechanisms implicated are diverse, inducing functional and structural changes in the myocardium. Insulin-like Growth Factor 1 (IGF-1) plays an important role in modulating the... | Chronic alcohol consumption significantly reduces IGF-1 myocardial expression. This decrease induced by alcohol is partially compensated in the presence of structural myocardial damage. | yes |
25,982,180 | Is serum vitamin D level associated with disease severity and response to ursodeoxycholic acid in primary biliary cirrhosis? | {
"contexts": [
"Serum vitamin D levels are associated with bone complications in patients with primary biliary cirrhosis (PBC). Increasing evidence suggests a nonskeletal role of vitamin D in various autoimmune and liver diseases.",
"To investigate the clinical relevance of vitamin D levels in PBC, especiall... | 25(OH)D level is associated with biochemical and histological features in PBC. Pre-treatment vitamin D status is independently related to subsequent response to UDCA. Our results suggest that vitamin D status may have important clinical significance in PBC. | yes |
25,986,753 | Does transcranial Magnetic Stimulation Combined with EEG reveal Covert States of Elevated Excitability in the Human Epileptic Brain? | {
"contexts": [
"Transcranial magnetic stimulation combined with electroencephalogram (TMS-EEG) can be used to explore the dynamical state of neuronal networks. In patients with epilepsy, TMS can induce epileptiform discharges (EDs) with a stochastic occurrence despite constant stimulation parameters. This observ... | In GGE, the interictal period contains multiple, quasi-stable covert states of excitability a class of which is associated with the generation of TMS-induced EDs. The relevance of these findings to theoretical models of ictogenesis is discussed. | yes |
25,958,926 | Is vosaroxin a novel topoisomerase-II inhibitor with efficacy in relapsed and refractory acute myeloid leukaemia? | {
"contexts": [
"Vosaroxin is a first-in-class anti-cancer quinolone that inhibits topoisomerase-II leading to cell cycle arrest and apoptosis. It has shown efficacy in a range of solid organ and haematopoietic tumours in vitro, and several clinical trials are underway or completed in the field of Acute Myeloid L... | Vosaroxin is a promising new agent in the treatment of AML, with the potential to improve CR rates in a high-risk group of patients with relapsed and refractory AML. However, higher CR rates have been associated with higher rates of treatment-related morbidity and mortality, especially in elderly/unfit patients. Maximi... | yes |
25,963,738 | Do diploid males support a two-step mechanism of endosymbiont-induced thelytoky in a parasitoid wasp? | {
"contexts": [
"Haplodiploidy, where females develop from diploid, fertilized eggs and males from haploid, unfertilized eggs, is abundant in some insect lineages. Some species in these lineages reproduce by thelytoky that is caused by infection with endosymbionts: infected females lay haploid eggs that undergo d... | Our new model of endosymbiont-induced thelytoky overthrows the view that certain sex determination mechanisms constrain the evolution of endosymbiont-induced thelytoky in hymenopteran insects. Endosymbionts can cause parthenogenesis through feminization, even in groups in which endosymbiont-diploidized eggs would devel... | yes |
25,987,435 | Does ancestral reconstruction of reproductive traits show no tendency toward terrestriality in leptodactyline frogs? | {
"contexts": [
"Traditionally, the evolution of terrestrial reproduction in anurans from ancestors that bred in water has been accepted in the literature. Still, the existence of intermediate stages of water dependency, such as species that lay eggs close to water (e.g., in burrows) instead of in bodies of water... | Our results found no evidence of evolutionary tendencies toward terrestriality in Leptodactylinae. We found reversals from terrestrial to aquatic tadpole development and no evidence of obligatory intermediate stages, such as semi-terrestrial reproductive strategies. We also found correlations between reproductive modes... | yes |
25,986,385 | Is use of proton pump inhibitors associated with fractures in young adults : a population-based study? | {
"contexts": [
"Proton pump inhibitors (PPIs) are associated with risk for fracture in osteoporotic adults. In this population-based study, we found a significant association between PPIs and fracture in young adults, with evidence of a dose-response effect. Young adults who use PPIs should be cautioned regardin... | PPI use was associated with fracture in young adults, but overall evidence did not support a PPI-fracture relationship in children. Young adults who use PPIs should be cautioned regarding potentially increased risk for fracture, even if they lack traditional fracture risk factors. | yes |
25,973,173 | Does up-regulation of the Hippo pathway effector TAZ render lung adenocarcinoma cells harboring EGFR-T790M mutation resistant to gefitinib? | {
"contexts": [
"The T790M mutation of epithelial growth factor receptor (EGFR) is a major cause of the acquired resistance to EGFR tyrosine kinase inhibitor (EGFR-TKIs) treatment for lung cancer patients. The Hippo pathway effector, TAZ, has emerged as a key player in organ growth and tumorigenesis, including lu... | Taken together, this study suggests that expression of TAZ is an intrinsic mechanism of T790M-induced resistance in response to EGFR-TKIs. Combinational targeting on both EGFR and TAZ may enhance the efficacy of EGFR-TKIs in acquired resistance of NSCLC. | yes |
25,973,171 | Is tetrandrine a potent cell autophagy agonist via activated intracellular reactive oxygen species? | {
"contexts": [
"Autophagy is an evolutionarily conserved cellular process that involves the lysosomal degradation of proteins and organelles and the recycling of cellular components to ensure cellular survival under external or internal stress. Numerous data has indicated that autophagy can be successfully targe... | Here, we report that tetrandrine is a potent cell autophagy agonist and may have a wide range of applications in the fields of antitumor therapy and basic scientific research. | yes |
25,979,689 | Does treatment with hydrogen molecule attenuate cardiac dysfunction in streptozotocin-induced diabetic mice? | {
"contexts": [
"Diabetic cardiomyopathy, a disorder of the heart muscle in diabetic patients, is one of the major causes of heart failure. The aim of present study was to investigate the therapeutic effect of hydrogen molecule on streptozotocin-induced diabetic cardiomyopathy in mice.",
"Diabetes was induced... | Treatment with hydrogen molecule attenuated cardiac dysfunction in streptozotocin-induced diabetic mice, which was independent of glycemic control. | yes |
25,986,147 | Do tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation? | {
"contexts": [
"Mutations of TBX5 cause Holt-Oram syndrome (HOS) in humans, a disease characterized by atrial or occasionally ventricular septal defects in the heart and skeletal abnormalities of the upper extremity. Previous studies have demonstrated that Tbx5 regulates Osr1 expression in the second heart field... | Tbx5 and Osr1 interact to regulate posterior SHF cell cycle progression for cardiac septation. | yes |
25,976,622 | Does serum miR-181b be Correlated with Hepatitis B Virus Replication and Disease Progression in Chronic Hepatitis B Patients? | {
"contexts": [
"Previously, we reported that microRNA-181b (miR-181b) activates hepatic stellate cells partly through the phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/Akt pathway.",
"The main objective of this study was to ascertain whether serum miR-181b expression is correlated with that ... | Serum miR-181b is correlated with liver and serum HBV DNA levels as well as disease progression in CHB. | yes |
25,975,199 | Do sequence and expression variations suggest an adaptive role for the DA1-like gene family in the evolution of soybeans? | {
"contexts": [
"The DA1 gene family is plant-specific and Arabidopsis DA1 regulates seed and organ size, but the functions in soybeans are unknown. The cultivated soybean (Glycine max) is believed to be domesticated from the annual wild soybeans (Glycine soja). To evaluate whether DA1-like genes were involved in... | Our work suggested that expression diversification of DA1-like genes is functionally associated with adaptive radiation of soybeans, reinforcing that the plant-specific DA1 gene family might have contributed to the successful adaption to complex environments and radiation of the plants. | yes |
25,981,335 | Does co-expression network of neural-differentiation genes show specific pattern in schizophrenia? | {
"contexts": [
"Schizophrenia is a neurodevelopmental disorder with genetic and environmental factors contributing to its pathogenesis, although the mechanism is unknown due to the difficulties in accessing diseased tissue during human neurodevelopment. The aim of this study was to find neuronal differentiation ... | This study supports the relevance of using cellular approaches to dissect molecular aspects of neurogenesis with impact in the schizophrenic brain. We showed that, although generated by different approaches, both sets of DEG associated to schizophrenia were involved with neocortical development. The results add to the ... | yes |
25,984,271 | Is serum Matrix Metalloproteinase-7 an independent prognostic biomarker in advanced bladder cancer? | {
"contexts": [
"Urine markers have been studied extensively but there is a lack of blood prognostic markers in bladder cancer. MMP-7 is produced by stromal cells and by tumor cells and is overexpressed in a variety of epithelial and mesenchymal tumors. In this study, we assessed with an immunoassay we developed,... | Our results show that the MMP-7 serum concentration is an independent prognostic factor in patients with locally advanced and or metastatic bladder cancer. | yes |
25,975,259 | Is soluble VE-cadherin involved in endothelial barrier breakdown in systemic inflammation and sepsis? | {
"contexts": [
"Microvascular endothelial barrier breakdown in sepsis precedes organ failure and death in patients. We tested the hypothesis that the formation of endothelium-derived soluble vascular endothelial (VE)-cadherin fragments (sVE-cadherin) is involved in inflammation-induced endothelial barrier disrup... | Taken together, formation of sVE-cadherin is associated and contributes to inflammation-induced breakdown of endothelial barrier functions by inhibition of VE-cadherin binding. The underlying mechanism of VE-cadherin cleavage involves ADAM10 and appears to be of clinical relevance since sVE-cadherin was augmented in pa... | yes |
25,968,453 | Does oral administration of Lactobacillus casei variety rhamnosus partially alleviate TMA-induced atopic dermatitis in mice through improving intestinal microbiota? | {
"contexts": [
"The purpose of this study was to investigate the effect of Lactobacillus casei variety rhamnosus (LCR35) on Atopic dermatitis (AD)-like symptoms in mice.",
"AD-like skin lesions in BALB/C mice were induced by sensitization and subsequent repeated challenges with trimellitic anhydride (TMA) fo... | LCR35 has the ability to suppress the development of AD in mice, possibly through the modulation of Th1/Th2 balance and gut microbiota. | yes |
25,975,912 | Does [ Epidermal growth factor-like domain 7 promote endothelial cell migration and angiogenesis by activating ERK signaling pathway ]? | {
"contexts": [
"To explore the effect of epidermal growth factor-like domain 7(EGFL7) on the migration and angiogenesis of endothelial cells.",
"EGFL7 overexpression vectors were constructed and transfected into human microvascular endothelial cells. The expression levels of EGFL7-mRNA and EGFL7 protein were... | EGFL7 effectively promotes migration and angiogenesis through ERK signaling pathway in endothelial cells. | yes |
25,982,204 | Does headache determine quality of life in idiopathic intracranial hypertension? | {
"contexts": [
"The effect of idiopathic intracranial hypertension (IIH) on quality of life (QOL) is poorly understood. Our objectives were to compare QOL in IIH to the normal UK population; to investigate QOL changes with treatment of IIH, using a weight loss intervention, and to determine which clinical factor... | QOL in IIH patients is significantly reduced. It improved with weight loss alongside significant improvement in clinical measures and headache. However, headache was the only clinical outcome that correlated with enhanced QOL. Effective headache management is required to improve QOL in IIH. | yes |
25,964,548 | Does combining CAL-101 with Celecoxib enhance Apoptosis of EBV-transformed B-Cells Through MAPK-induced ER Stress? | {
"contexts": [
"Phosphoinositide-3 kinase (PI3K) inhibition attenuates proliferation and survival in B-cell malignancies. Celecoxib induces endoplasmic reticulum (ER) stress-induced apoptosis via a cyclo-oxgenase-2 (COX2)-independent manner in certain types of cancer cells. In the present study, we assessed the ... | The apoptosis of EBV-transformed B-cells and NHL cells caused by CAL-101 and celecoxib might be related to inhibiting the RHOA/ROCK pathway and might also be associated with mitogen-activated protein kinase (MAPK)-mediated ER stress. | yes |
25,964,543 | Does pentraxin-3 Silencing suppress Gastric Cancer-related Inflammation by Inhibiting Chemotactic Migration of Macrophages? | {
"contexts": [
"Chronic inflammation characterized by the recruitment and activation of macrophages has been implicated in the development of gastric cancer.",
"Expression of the long form of pentraxin-3 (PTX3) in gastric cancer cells was examined by reverse transcription-polymerase chain reaction and enzyme... | Our findings suggest that gastric cancer-derived PTX3 promotes macrophage recruitment, which may contribute to gastric cancer-related inflammation. | yes |
25,964,540 | Does kaempferol be an Anti-Inflammatory Compound with Activity towards NF-κB Pathway Proteins? | {
"contexts": [
"The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway is critical in inflammation, proliferation and carcinogenesis. There exist three main players in this pathway. The inhibitor of NF-κB (IκB), IκB kinase (IκK)- NF-κB essential modulator (NEMO) complex and NF-κB. The... | We conclude that kaempferol possesses anti-inflammatory activity. | yes |
25,964,546 | Do endothelial Cells Derived from Non-malignant Tissues Are of Limited Value as Models for Brain Tumor Vasculature? | {
"contexts": [
"Human umbilical cord vein endothelial cells (HUVECs) are commonly chosen over freshly isolated endothelial cells from glioblastomas (GECs) due to accessibility and costs.",
"To test their suitability for in vitro studies, we comprehensively compared the transcriptomes and responses to major a... | Given our findings, we strongly recommend the use of GECs as model cells for brain tumor endothelium for experiments investigating angiogenesis and immunobiology. | yes |
25,984,475 | Do effects of endodontic tri-antibiotic paste on bond strengths of dentin adhesives to coronal dentin? | {
"contexts": [
"The aim of this study was to evaluate the effects of tri-antibiotic paste (TAP) on microtensile bond strengths (MTBS) of dental adhesives to dentin.",
"Sixty extracted molars had their occlusal surfaces flattened to expose dentin. They were divided into two groups, i.e., control group with no... | The etch-and-rinse adhesive Adper Single Bond Plus presented higher mean bond strengths than the self-etch adhesive Filtek P90, irrespective of the group. The superior bond performance for Adper Single Bond when compared to Filtek P90 adhesive was confirmed by a fewer number of adhesive failures. The influence of TAP i... | yes |
25,987,914 | Is physician documentation of sepsis syndrome associated with more aggressive treatment? | {
"contexts": [
"Timely recognition and treatment of sepsis improves survival. The objective is to examine the association between recognition of sepsis and timeliness of treatments.",
"We identified a retrospective cohort of emergency department (ED) patients with positive blood cultures from May 2007 to Jan... | Patients whose emergency physicians articulated sepsis syndrome in their documentation or who launched the sepsis order set received antibiotics sooner and received more total volume of fluid. Age <60 and absence of fever are factors associated with lack of recognition of sepsis cases. | yes |
25,988,769 | Does oral zinc supplementation reduce the erythropoietin responsiveness index in patients on hemodialysis? | {
"contexts": [
"In hemodialysis (HD) patients, zinc depletion caused by inadequate intake, malabsorption, and removal by HD treatment leads to erythropoiesis-stimulating agent (ESA) hyporesponsiveness. This study investigated the effects of zinc supplementation in HD patients with zinc deficiency on changes in t... | Zinc supplementation reduces ERI in patients undergoing HD and may be a novel therapeutic strategy for patients with renal anemia and low serum zinc levels. | yes |
25,972,489 | Is components separation technique feasible for assisting delayed primary fascial closure of open abdomen? | {
"contexts": [
"The goal after open abdomen treatment is to reach primary fascial closure. Modern negative pressure wound therapy systems are sometimes inefficient for this purpose. This retrospective chart analysis describes the use of the 'components separation' method in facilitating primary fascial closure a... | Components separation is a useful method in contributing to successful primary fascial closure in patients treated for open abdomen. Best results were obtained when components separation was performed simultaneously with primary fascial closure at the end of the open abdomen treatment. | yes |
25,985,825 | Are female third party lymphocytes effective for immunotherapy of patients with unexplained primary recurrent spontaneous abortion : A retrospective analysis of outcomes? | {
"contexts": [
"Allogeneic lymphocytes of paternal origin or supplied by a male third party have been used for the treatment of recurrent spontaneous abortion. Few studies, however, have examined the use of female third party lymphocytes. Our purpose was to determine whether female third party lymphocytes could ... | We conclude that female third party lymphocytes can be used for immunotherapy in patients with recurrent spontaneous abortion. | yes |
25,962,313 | Does acute but not chronic activation of brain glucagon-like peptide-1 receptors enhance glucose-stimulated insulin secretion in mice? | {
"contexts": [
"To investigate the role of brain glucagon-like peptide-1 (GLP-1) in pancreatic β-cell function.",
"To determine the role of brain GLP-1 receptor (GLP-1R) on β-cell function, we administered intracerebroventricular (i.c.v.) infusions of GLP-1 or the specific GLP-1 antagonist exendin-9 (Ex-9), ... | Our results indicate that, under non-clamped conditions, brain GLP-1 plays a functional neuroendocrine role in the acute regulation of glucose homeostasis in both lean and obese rodents. | yes |
25,973,390 | Is activation of natriuretic peptides and the sympathetic nervous system following Roux-en-Y gastric bypass associated with gonadal adipose tissues browning? | {
"contexts": [
"Roux-en-Y gastric bypass (RYGB) is an effective method of weight loss and remediation of type-2 diabetes; however, the mechanisms leading to these improvements are unclear. Additionally, adipocytes within white adipose tissue (WAT) depots can manifest characteristics of brown adipocytes. These 'B... | Upregulation of Nppb, Npr1, Npr2, and β3-adrenergic receptors in gonadal adipose tissue following RYGB was associated with increased markers of browning. This browning of gonadal adipose tissue may underpin the positive effect of RYGB on metabolic parameters and may in part be mediated through upregulation of natriuret... | yes |
25,960,836 | Does rituximab lead to long remissions in patients with chronic immune thrombocytopenia? | {
"contexts": [
"To assess the response rate and duration of response in patients with chronic immune thrombocytopenia (ITP) receiving rituximab.",
"We retrospectively analyzed 32 consecutive patients with chronic ITP who were treated in two tertiary centers in Oman. Response assessment was based on the Ameri... | The use of rituximab in ITP achieves high response rate and long remission duration. Our study was limited by the small sample size and further larger prospective studies are recommended. | yes |
25,970,109 | Is bordetella pertussis an uncommon pathogen in children hospitalized with bronchiolitis during the winter season? | {
"contexts": [
"In the United States (U.S.), Bordetella pertussis incidence has increased. Cough and apnea are common findings in pertussis and also in bronchiolitis, the most common cause of hospitalization in U.S. infants. The objective was to determine the prevalence of B. pertussis infection in children hosp... | Our data support that B. pertussis is an uncommon pathogen in U.S. children hospitalized with bronchiolitis in the winter. Making a diagnosis of pertussis can be challenging because the disease can be atypical and may not meet the Centers for Disease Control and Prevention definition of probable infection. | yes |
25,959,048 | Is continuous minimally invasive cardiac output monitoring with the COstatus in a neonatal swine model : recalibration necessary during vasoconstriction and vasodilation? | {
"contexts": [
"The COstatus monitor measures cardiac output via the transpulmonary ultrasound dilution method (COTPUD ) after injection of normal saline, and can calculate continuous cardiac output (CCO) from the arterial pressure waveform. The relationship between arterial waveform and COTPUD however, might be... | Continuous cardiac output (CO) measured with the COstatus monitor requires recalibration during vasoconstriction and vasodilation, even if changes in COTPUD or SVR are not substantial. | yes |
25,959,049 | Is hepatic steatosis associated with lower levels of physical activity measured via accelerometry? | {
"contexts": [
"Prior studies on the association of physical activity (PA) and nonalcoholic fatty liver disease are limited by reliance on subjective measures of PA. We examined the association between objectively measured PA and hepatic steatosis defined by computed tomography (CT).",
"We conducted a cross-... | There is an inverse association between PA and hepatic steatosis. Participants who met the national PA guidelines had the lowest prevalence of hepatic steatosis. | yes |
25,959,045 | Do ecological evidence that affect and perceptions of drink effects depend on alcohol expectancies? | {
"contexts": [
"(1) To compare affective changes over drinking and non-drinking days among frequent drinkers and (2) to evaluate whether drinkers' expectations influence affective changes and perceived pleasure and relief from drinking.",
"Observational study involving ecological momentary assessments collec... | Although theoretical models tend to focus on negative affective outcomes of drinking, changes in positive affect prior to drinking and early in drinking episodes are important for maintaining drinking behavior. Frequent drinkers' expectations for enhanced sociability or tension reduction from drinking influence their a... | yes |
25,981,924 | Does pharmacokinetic synergy from the taxane extract of Taxus chinensis improve the bioavailability of paclitaxel? | {
"contexts": [
"Taxus chinensis (Pilger) Rehd is widely distributed in China and the northern hemisphere, and the most popular medicinal component isolated from Taxus chinensis is paclitaxel (PTX), which has now become the first-line chemotherapeutic drug for breast cancer and ovarian cancer. Oral administration... | Together, these results support that administration of PTX in the form of taxane mixtures may become a novel approach to improve the poor bioavailability of PTX. Moreover, the inherent synergy from Taxus chinensis taxane extracts promises a novel strategy to strengthen PTX efficacy. | yes |
25,981,922 | Does marsdenia tenacissima extract enhance gefitinib efficacy in non-small cell lung cancer xenografts? | {
"contexts": [
"The stem of Marsdenia tenacissima (Roxb.) Wight et Arn. has long been used as a medicine to treat cancer in China. Our previous in vitro results showed that Marsdenia tenacissima extract (MTE) overcomes gefitinib resistance in non-small cell lung cancer (NSCLC) cells. However, it is unknown wheth... | The present results suggest that the combination of MTE and gefitinib may be a promising therapeutic approach to enhance gefitinib efficacy in resistant NSCLC. | yes |
25,985,710 | Do peripheral blood mononuclear cells from severe asthmatic children release lower amounts of IL-12 and IL-4 after LPS stimulation? | {
"contexts": [
"Asthma is an inflammatory disorder of the airways associated with bronchial hyperresponsiveness, airway obstruction, and increased mucus production, with a predominance of type 2 immune response (Th2). According to the hygiene hypothesis, exposure to environmental bacterial lipopolysaccharide (LP... | Our results demonstrate that LPS directly influence the cytokine profile of PBMC in children with severe asthma. These observations may be potentially helpful in developing new treatment strategies. | yes |
25,962,734 | Is plasma oligomeric alpha-synuclein associated with glucocerebrosidase activity in Gaucher disease? | {
"contexts": [
"The link between Parkinson's disease (PD) and Gaucher disease (GD), the most common lysosomal storage disease associated with loss of glucocerebrosidase (GBA) activity, can be explained by abnormal accumulation of oligomeric alpha-synuclein (α-Syn) species resulting from mutations in the GBA gene... | The decrease in GBA activity may influence α-Syn oligomerization, explaining the high risk of PD development in GD patients. © 2015 International Parkinson and Movement Disorder Society. | yes |
25,961,168 | Do influence of torsional strength on different types of dental implant platforms? | {
"contexts": [
"The study assessed deformation of implant components submitted to torsion tests of 80 and 120 N · cm using an optical stereomicroscope.",
"The following 3 types of Titaniumfix conical implant connections (n = 5) measuring Ø 4.0 × 11.5 mm were used: external, internal hexagon and Morse taper c... | For all the implants, high insertion torques deformed the implant platform preventing long-term maintenance and stability of implants. | yes |
25,972,430 | Does glutamine restore Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome? | {
"contexts": [
"Recent studies showed that patients with diarrhea-predominant irritable bowel syndrome (IBS-D) had an increased intestinal permeability as well as a decreased expression of tight junctions. Glutamine, the major substrate of rapidly dividing cells, is able to modulate intestinal permeability and t... | Glutamine increased claudin-1 expression in the colonic mucosa of patients with IBS-D. In addition, glutamine effect seems to be dependent on basal expression of tight junction proteins. | yes |
25,983,821 | Does surgical result after unilateral laminectomy for the removal of spinal cord tumors? | {
"contexts": [
"To reduce the risk of postoperative spinal instability or deformity, unilateral laminectomy (UL) has been recommended to remove spinal space-occupying lesions. The purpose of this study was to determine whether there were any advantages of UL for removal of spinal cord tumors.",
"From May 199... | UL is an optimal approach for providing sufficient exposure of spinal cord tumors without development of postoperative spinal instability and regional sagittal imbalance in any location of spinal column. In cases of meningioma, careful long-term follow up is needed due to it's relatively high recurrence rate after remo... | yes |
25,985,890 | Does cOPART Risk Score predict Long-term Mortality in Peripheral Arterial Occlusive Disease? | {
"contexts": [
"The COhorte de Patients ARTériopathes (COPART) Risk Score is a risk score assessing the 1 year outcome of patients who received inpatient treatment because of their peripheral arterial occlusive disease (PAOD). The COPART Risk Score consists of six variables each of which is allocated a different... | The COPART Risk Score is a suitable instrument to predict long-term all cause and CV mortality in claudicants preceding their first peripheral intervention. | yes |
25,962,604 | Is expression of bone morphogenetic proteins 4 , 6 and 7 downregulated in kidney allografts with interstitial fibrosis and tubular atrophy? | {
"contexts": [
"Bone morphogenetic proteins (BMPs) are pleiotropic growth factors. This paper investigates the connection between the expression pattern of BMPs in kidney allograft tissue versus the cause of allograft dysfunction.",
"The expression pattern of BMP2, BMP4, BMP6 and BMP7 in 50 kidney allografts... | The intensity and expression pattern of BMP4, BMP6 and BMP7 in transplanted kidney tissue are found to be dependent upon the length of the transplanted period, the clinical indication for transplant nephrectomy and signs of IFTA in kidney tissue. | yes |
25,961,568 | Does the temporal expression pattern of alpha-synuclein modulate olfactory neurogenesis in transgenic mice? | {
"contexts": [
"Adult neurogenesis mirrors the brain´s endogenous capacity to generate new neurons throughout life. In the subventricular zone/ olfactory bulb system adult neurogenesis is linked to physiological olfactory function and has been shown to be impaired in murine models of neuronal alpha-Synuclein ove... | The dissociation between higher absolute expression levels of alpha-Synuclein but less severe impact on adult olfactory neurogenesis in mThy1 transgenic mice highlights the importance of temporal expression characteristics of alpha-Synuclein on the maturation of newborn neurons. | yes |
25,960,388 | Does lichen endophyte derived pyridoxatin inactivate Candida growth by interfering with ergosterol biosynthesis? | {
"contexts": [
"This study is to characterize the antifungal effects of pyridoxatin (PYR), a small natural product isolated from an endolichenic fungus.",
"The susceptibility tests in vitro and in vivo by using Caenorhabditis elegans as an infectious model were performed to evaluate the antifungal efficacy o... | PYR interferes with the ergosterol synthesis to exert antifungal action. | yes |
25,958,831 | Does carotid sparing intensity-modulated radiation therapy achieve comparable locoregional control to conventional radiotherapy in T1-2N0 laryngeal carcinoma? | {
"contexts": [
"Although intensity-modulated radiotherapy (IMRT) is a standard of care for many head and neck cancers, its use for carotid-sparing (CS) therapy in early-stage laryngeal carcinoma is controversial.",
"330 consecutive patients with early-stage laryngeal carcinoma were treated from 1/1989 to 5/2... | These results warrant further prospective evaluation of CS-IMRT for early-stage glottic larynx cancer. | yes |
25,974,736 | Does severe Obesity in Adolescents and Young Adults be Associated With Subclinical Cardiac and Vascular Changes? | {
"contexts": [
"Severe obesity is the fastest growing subgroup of obesity in youth.",
"We sought to explore the association between severe obesity and subclinical measures of cardiac and vascular structure and function in adolescents and young adults.",
"This was a cross-sectional comparison of 265 adole... | Adolescents and young adults with severe obesity have a more adverse cardiovascular risk profile and worse cardiac and vascular structure and function. More importantly, severe obesity is independently associated with these subclinical cardiac and vascular changes. | yes |
25,986,365 | Is a smaller amygdala associated with anxiety in Parkinson 's disease : a combined FreeSurfer-VBM study? | {
"contexts": [
"Up to 50% of all patients with Parkinson's disease (PD) suffer from anxiety symptoms, a much higher percentage than in the general population. This suggests that PD associated pathological alterations partly underlie these symptoms, although empirical evidence is limited.",
"Here we investiga... | These results confirm studies in non-PD samples showing lower left amygdalar volume in anxious patients. The results also indicate that the 'psychological' BAI subscale is a better reflection of neural correlates of anxiety in PD. Whether the left amygdalar volume decrease constitutes a premorbid trait, a PD-associated... | yes |
25,986,360 | Is cyst Fluid Glucose Rapidly Feasible and Accurate in Diagnosing Mucinous Pancreatic Cysts? | {
"contexts": [
"Better diagnostic tools are needed to differentiate pancreatic cyst subtypes. A previous metabolomic study showed cyst fluid glucose as a potential marker to differentiate mucinous from non-mucinous pancreatic cysts. This study seeks to validate these earlier findings using a standard laboratory ... | Glucose, whether measured by a laboratory assay, a glucometer, or a reagent strip, is significantly lower in mucinous cysts compared with non-mucinous pancreatic cysts. | yes |
25,977,321 | Do a User-Developed 3-D Hand Gesture Set for Human-Computer Interaction? | {
"contexts": [
"The purpose of this study was to develop a lexicon for 3-D hand gestures for common human-computer interaction (HCI) tasks by considering usability and effort ratings.",
"Recent technologies create an opportunity for developing a free-form 3-D hand gesture lexicon for HCI.",
"Subjects (N ... | A method is proposed for generating a user-developed 3-D gesture lexicon for common HCIs that involves subjective ratings and a posture risk rating for minimizing arm and hand fatigue. | yes |
25,960,337 | Does an iterative approach to respiratory self-navigated whole-heart coronary MRA significantly improve image quality in a preliminary patient study? | {
"contexts": [
"In respiratory self-navigated coronary MRA, the selection of a reference position may have a direct effect on image quality. While end-expiration is commonly used as reference, it may be ill defined in cases of irregular breathing. Here, an iterative self-navigation approach that operates without... | An iterative approach to respiratory motion correction in self-navigation may lead to significant improvements in coronary MRA image quality in patients with a less consistent end-expiratory respiratory phase. | yes |
25,968,104 | Is hIV infection associated with an increased prevalence of coronary noncalcified plaque among participants with a coronary artery calcium score of zero : Multicenter AIDS Cohort Study ( MACS )? | {
"contexts": [
"HIV-infected individuals bear increased cardiovascular risk even in the absence of traditional cardiovascular risk factors. In the general population, coronary artery calcium (CAC) scanning is of value for cardiovascular risk stratification, but whether a CAC score of zero implies a low noncalcif... | Among men with CAC scores of zero, HIV infection is associated with an increased prevalence of noncalcified coronary plaque independent of traditional cardiovascular risk factors. This finding suggests that CAC scanning may underestimate plaque burden in HIV-infected men. | yes |
25,982,813 | Are free thyroxine levels associated with cognitive abilities in subjects with early psychosis? | {
"contexts": [
"Subjects with a psychotic disorder show mild to moderate cognitive impairment, which is an important determinant of functional outcome. The underlying biological process of cognitive impairment in psychosis is unclear. We aimed to explore whether hypothalamic-pituitary-thyroid axis hormones or th... | Our study suggests that FT4 levels are associated with cognitive abilities (attention/vigilance and overall cognition) in individuals with early psychosis. | yes |
25,986,212 | Is neighborhood socioeconomic status associated with violent reinjury? | {
"contexts": [
"Measures of individual socioeconomic status correlate with recurrent violent injury; however, neighborhood socioeconomic status may also matter. We conducted a review of victims of interpersonal violence treated at our trauma center, hypothesizing that the percent of the population living under t... | For young patients injured by violence, the socioeconomic position of their neighborhood of residence is independently correlated with their risk of violent reinjury. Low neighborhood socioeconomic status may be associated with a disrupted sense of safety after injury and also may alter a person's likelihood of engagin... | yes |
25,986,210 | Are trauma systems associated with increased level 3 trauma centers? | {
"contexts": [
"State-supported trauma systems have a proven association with improved mortality, but to date, there are no data reported on what mechanism leads to this benefit. Our hypothesis is that trauma systems with funding support are associated with increased number of trauma centers (TCs).",
"A retr... | Our study shows that the number of level 3 TCs significantly and independently correlated with the presence of a funded trauma system. The number of level 1 and 2 centers showed no such correlation. Further study will determine if increased number of level 3 centers leads to improved clinical outcome. | yes |
25,986,392 | Do gastric cancer-derived mesenchymal stem cells prompt gastric cancer progression through secretion of interleukin-8? | {
"contexts": [
"Bone marrow mesenchymal stem cells (BM-MSCs) have been identified to be closely associated with tumor growth and progression. However, the roles of tumor-resident MSCs in cancer have not been thoroughly clarified. This study was to investigate the regulating effect of gastric cancer-derived MSCs ... | Tumor-resident GC-MSCs promote gastric cancer growth and progression more efficiently than GCN-MSCs or BM-MSCs through a considerable secretion of IL-8, which could be a possible target for gastric cancer therapy. | yes |
25,985,398 | Does cell-to-cell contact facilitate HIV transmission from lymphocytes to astrocytes via CXCR4? | {
"contexts": [
"HIV reservoir in the brain represents a major barrier for curing HIV infection. As the most abundant, long-lived cell type, astrocytes play a critical role in maintaining the reservoir; however, the mechanism of infection remains unknown. Here, we determine how viral transmission occurs from HIV-... | Cell-to-cell transmission was mediated by a unique mechanism by which immature viral particles initiated a fusion process in a CXCR4-dependent, CD4-independent manner. These observations have important implications for developing approaches to prevent formation of HIV reservoirs in the brain. | yes |
25,986,158 | Does moderate physical training attenuate perinatal low-protein-induced spleen lymphocyte apoptosis in endotoxemic adult offspring rats? | {
"contexts": [
"To evaluate the effects of a moderate physical training (T) on the blood and splenic lymphocytes subsets and the rate of apoptosis in adult offspring submitted to perinatal low-protein (LP) diet.",
"Male Wistar rats were divided according to their mother's diet: control (C, 17 % casein) and u... | Moderate physical training was able to revert the effects of perinatal LP diet on circulation lymphocytes subsets and attenuated splenic lymphocytes apoptosis and plasma TNF-α concentrations. | yes |
25,975,951 | Does bAFF promote proliferation of human mesangial cells through interaction with BAFF-R? | {
"contexts": [
"B cell activating factor belonging to the TNF family (BAFF) is vital for B cell survival, proliferation and activation. Evidence indicates that BAFF is systemically or locally increased in glomerulonephritis (e.g. lupus nephritis, IgA nephropathy). However, the effect of BAFF on human mesangial c... | BAFF promoted proliferation of human mesangial cells, which was mediated via BAFF-R. The BAFF/BAFF-R interaction triggered Akt, p65 and p38 activation, with Akt phosphorylation being tightly dependent on BAFF/BAFF-R interaction. | yes |
25,967,976 | Is protein Phosphatase 1 Beta Modulated by Chronic Hypoxia and Involved in the Angiogenic Endothelial Cell Migration? | {
"contexts": [
"Endothelial cell migration is required for physiological angiogenesis, but also contributes to various pathological conditions, including tumour vascularization. The mRNA expression of PP1cβ, the beta isoform of the catalytic PP1 subunit, was shown to be upregulated in chronic hypoxia. Since hypo... | PP1cβ is regulator of endothelial cell migration, which is critical in the angiogenic process. PP1cβ inhibition reduces endothelial cell migration through focal adhesion turnover and actin polymerization pathways. | yes |
25,967,975 | Does dexmedetomidine attenuate blood-spinal cord barrier disruption induced by spinal cord ischemia reperfusion injury in rats? | {
"contexts": [
"Dexmedetomidine has beneficial effects on ischemia reperfusion (I/R) injury to the spinal cord, but the underlying mechanisms are not fully understood. This study investigated the effects and possible mechanisms of dexmedetomidine on blood-spinal cord barrier (BSCB) disruption induced by spinal c... | Dexmedetomidine preconditioning stabilized the BSCB integrity against spinal cord I/R injury by inhibition of MMP-9, and enhancing the Ang1-Tie2 system. | yes |
25,967,971 | Does baicalein inhibit MMPs Expression via a MAPK-Dependent Mechanism in Chondrocytes? | {
"contexts": [
"Baicalein is a flavonoid isolated from Scutellaria baicalensis Georgi. Here, we investigated the anti-osteoarthritic effect of baicalein in vitro and in vivo.",
"Interleukin-1 beta (IL-1β)-induced chondrocytes were treated with different concentrations of baicalein, real-time PCR and ELISA we... | The results indicate that baicalein may be considered as a potential agent for OA treatment. | yes |
25,967,970 | Does cinnamaldehyde prevent endothelial dysfunction induced by high glucose by activating Nrf2? | {
"contexts": [
"It is well documented that hyperglycemia-induced oxidative stress is an important causative factor of endothelial dysfunction. Cinnamaldehyde (CA) is a key flavor compound in cinnamon essential oil that can enhance the antioxidant defense against reactive oxygen species (ROS) by activating NF-E2-... | Our results indicated that CA protected endothelial dysfunction under high glucose conditions and this effect was mediated by Nrf2 activation and the up-regulation of downstream target proteins. CA administration may represent a promising intervention in diabetic patients who are at risk for vascular complications. | yes |
25,982,670 | Does low left atrial appendage flow velocity predict recurrence of atrial fibrillation after catheter ablation of persistent atrial fibrillation? | {
"contexts": [
"Recurrence after catheter ablation of persistent atrial fibrillation (AF) remains an unsolved issue. This study aimed to explore the association between the left atrial appendage peak flow velocity (LAAV) and AF recurrence after ablation in persistent AF patients.",
"Fifty-three consecutive p... | A low LAAV was associated with AF recurrence after the initial catheter ablation of persistent AF. | yes |
25,981,324 | Is polymorphisms of rs174616 in the FADS1-FADS2 gene cluster associated with a reduced risk of type 2 diabetes mellitus in northern Han Chinese people? | {
"contexts": [
"Several studies have shown associations between the composition of polyunsaturated fatty acids (PUFAs) in various tissues and type 2 diabetes mellitus (T2DM) development in European populations. Genetic variants of fatty acid desaturase (FADS) contribute to the variations of PUFA composition. Her... | These data suggest that in northern Han Chinese people, the minor allele (T) of rs174616 in the FADS1-FADS2 gene cluster is associated with a decreased conversion rate of LA to AA, which may contribute to decreased reduced risk of developing T2DM. | yes |
25,981,325 | Does bile acid binding resin improve hepatic insulin sensitivity by reducing cholesterol but not triglyceride levels in the liver? | {
"contexts": [
"Bile acid binding resin (BAR) improves glycaemic control in patients with type 2 diabetes. Although the mechanism is hypothesised to involve the clearance of excess hepatic triglyceride, this hypothesis has not been examined in appropriately designed studies. Therefore, we investigated whether re... | BAR improved hepatic insulin resistance in FLS mice by reducing hepatic cholesterol without affecting hepatic triglyceride levels or body fat distribution. Our study revealed that BAR improves glycaemic control at least in part by downregulating the hepatic cholesterol-LXR-IRS2 pathway. | yes |
25,981,321 | Is no evidence that genetically reduced 25-hydroxyvitamin D associated with increased risk of ischaemic heart disease or myocardial infarction : a Mendelian randomization study? | {
"contexts": [
"Low plasma 25-hydroxyvitamin D [p-25(OH)D] is associated with increased risk of ischaemic heart disease and with the subgroup myocardial infarction. However, whether this association is causal or due to confounding or reverse causation is presently unknown. We tested the hypothesis that genetical... | We found no evidence to suggest that genetically reduced p-25(OH)D is associated with increased risk of ischaemic heart disease or myocardial infarction. | yes |
25,974,927 | Does acoustic feature for the Identification of Coronary Artery Disease? | {
"contexts": [
"Earlier studies have documented that coronary artery disease (CAD) produces weak murmurs, which might be detected through analysis of heart sounds. An electronic stethoscope with a digital signal processing unit could be a low cost and easily applied method for diagnosis of CAD. The current study... | The result confirms that there is a potential in heart sounds for the diagnosis of CAD, but that further improvements are necessary to gain clinical relevance. | yes |
25,968,441 | Is co-administration of α-lipoic acid and glutathione associated with no significant changes in serum bilirubin , alkaline phosphatase or γ-glutamyltranspeptidase levels during the treatment of neuroborreliosis with intravenous ceftriaxone? | {
"contexts": [
"While pharmacotherapy with intravenous ceftriaxone, a third-generation cephalosporin, is a potential treatment of Lyme neuroborreliosis, there is concern that it can cause the formation of biliary sludge, leading to hepatobiliary complications such as biliary colic, jaundice and cholelithiasis, w... | Co-administration of α-lipoic acid and glutathione is associated with no significant changes in serum bilirubin, alkaline phosphatase or γ-glutamyltranspeptidase levels during the treatment of neuroborreliosis with intravenous ceftriaxone. | yes |
25,972,231 | Is oncostatin M a potential agent for the treatment of obesity and related metabolic disorders : a study in mice? | {
"contexts": [
"Obesity and insulin resistance are closely associated with adipose tissue dysfunction caused by the abnormal recruitment of inflammatory cells, including macrophages. Oncostatin M (OSM), a member of the IL-6 family of cytokines, plays important roles in a variety of biological functions including... | We showed that OSM is a novel candidate to act as a powerful therapeutic agent for the treatment of obesity-induced metabolic disorders. | yes |
25,960,958 | Is systemic oxidative stress to nucleic acids unaltered following radioiodine therapy of patients with benign nodular goiter? | {
"contexts": [
"Little is known about the whole body oxidative stress burden following radioactive iodine ((131)I) therapy of thyroid diseases.",
"We studied 17 patients with benign nodular goiter treated with (131)I therapy. The targeted thyroid dose was 50 Gy in 11 patients pretreated with 0.1 mg of recomb... | Systemic oxidative stress, as detected by nucleic acids metabolites in the urine, is not increased after thyroid stimulation with 0.1 mg of rhTSH, or after (131)I therapy. Our method cannot quantify the oxidative stress induced locally in the thyroid gland, but the study supports that (131)I therapy of benign nodular g... | yes |
25,979,239 | Does anemia be a Risk Factor of New Intraoperative Hemorrhagic Stroke During Valve Surgery for Endocarditis? | {
"contexts": [
"Infective endocarditis is often associated with cerebral complications, the most serious of which is intraoperative hemorrhagic stroke owing to anticoagulation for cardiopulmonary bypass. However, its prevalence and risk factors are unknown. We evaluated the prevalence and risk factors of intraop... | Intraoperative hemorrhagic stroke was not rare, and ectopic hemorrhagic stroke, associated with preoperative anemia, was more prevalent than hemorrhagic transformation of existing cerebral lesions. | yes |
25,972,699 | Is thromboembolic disease after knee arthroplasty rare in Southern Iran? | {
"contexts": [
"Thromboembolic disease (TED) after knee arthroplasty occurs infrequently in Iran. The aim of this study was to examine the incidence of TED in patients with osteoarthritis undergoing knee replacement in Southern Iran while on prophylaxis.",
"In a case series study from January to December 201... | No clinically significant DVT was found using either enoxaparin or warfarin prophylaxis after TKA in Southern Iran. Relatively excessive postoperative bleeding was observed, particularly with enoxaparin. | yes |
25,964,552 | Does gemcitabine induce Radiosensitization Through Inhibition of RAD51-dependent Repair for DNA Double-strand Breaks? | {
"contexts": [
"Gemcitabine (GEM) is used in clinical chemo-radiotherapy; however, the mechanism that contributes to enhanced radiosensitivity by GEM is not fully-understood. We evaluated the effect of GEM on radiosensitization in pancreatic cancer cell lines.",
"Pancreatic cell lines PK-59 and PK-45p were u... | RAD51-dependent homologous recombination is one of the key targets in the GEM-induced radiosensitizing effect. | yes |
25,964,557 | Does aquaporin 3 Expression predict Survival in Patients with HER2-positive Early Breast Cancer? | {
"contexts": [
"Recent studies have revealed aquaporins (AQPs) as targets for novel anti-tumor therapy since they are likely to play a role in carcinogenesis, tumor progression and invasion. Accordingly, we analyzed the prognostic impact of AQP3 expression and polymorphisms in a number of patients with early bre... | AQP3 expression in tumor tissue may be considered as a potential prognostic marker in patients with HER2-over-expressing EBC after curative surgery. | yes |
25,975,821 | Does microarray transcriptional profiling of Arctic Mesorhizobium strain N33 at low temperature provide insights into cold adaption strategies? | {
"contexts": [
"Arctic Mesorhizobium strain N33 was isolated from nodules of the legume Oxytropis arctobia in Canada's eastern Arctic. This symbiotic bacterium can grow at temperatures ranging from 0 to 30 °C, fix nitrogen at 10 °C, and is one of the best known cold-adapted rhizobia. Despite the economic potenti... | Our analysis revealed a complex series of changes associated with cold exposure adaptation and constant growth at low temperatures. Moreover, it highlighted some of the strategies and different physiological states that Mesorhizobium strain N33 has developed to adapt to the cold environment of the Canadian high Arctic ... | yes |
25,971,350 | Are eRRγ target genes poor prognostic factors in Tamoxifen-treated breast cancer? | {
"contexts": [
"One-third of estrogen (ER+) and/or progesterone receptor-positive (PGR+) breast tumors treated with Tamoxifen (TAM) do not respond to initial treatment, and the remaining 70% are at risk to relapse in the future. Estrogen-related receptor gamma (ESRRG, ERRγ) is an orphan nuclear receptor with bro... | ERRγ signaling is associated with poor DMFS in ER+, TAM-treated breast cancer, and ESRRG, EEF1A2, and PPIF comprise a 3-gene signaling node that may contribute to TAM resistance in the context of an active ERK/MAPK pathway. | yes |
25,972,302 | Does adenosine testing after second-generation cryoballoon ablation ( ATSCA ) study improve clinical success rate for atrial fibrillation? | {
"contexts": [
"Adenosine administration after pulmonary vein (PV) isolation using radiofrequency, laser, and cryoablation can cause acute recovery of conduction to the PVs and predict atrial fibrillation (AF) recurrence. This study evaluates whether ablation of dormant potentials post-adenosine administration f... | Adenosine testing after second-generation cryoballoon ablation study showed that reablation of initially isolated PVs increases the clinical success rate for AF. | yes |
25,972,301 | Does the ratio of the neutrophil leucocytes to the lymphocytes predict the outcome after cardiac resynchronization therapy? | {
"contexts": [
"The low lymphocyte counts and high neutrophil leucocyte fractions have been associated with poor prognosis in chronic heart failure. We hypothesized that the baseline ratio of the neutrophil leucocytes to the lymphocytes (NL ratio) would predict the outcome of chronic heart failure patients under... | The NL ratio is elevated in chronic heart failure and predicts outcome after CRT. According to the reclassification analysis, 4% of the patients would have been better categorized in the prediction models by combining the NT-proBNP with the NL ratio. Thus, a single blood count measurement could facilitate the optimal p... | yes |
25,963,394 | Are changes in Autonomic Nervous System Activity Associated with Changes in Sexual Function in Women with a History of Childhood Sexual Abuse? | {
"contexts": [
"Women with histories of childhood sexual abuse (CSA) have higher rates of sexual difficulties, as well as high sympathetic nervous system response to sexual stimuli.",
"The study aims to examine whether treatment-related changes in autonomic balance, as indexed by heart rate variability (HRV)... | Treatments that reduce autonomic imbalance may improve sexual well-being among CSA populations. | yes |
25,986,694 | Is eukaryotic translation elongation factor-1 alpha associated with a specific subset of mRNAs in Trypanosoma cruzi? | {
"contexts": [
"Regulation of gene expression in trypanosomatids is mainly posttranscriptional. Tight regulation of mRNA stability and access to polysomes allows Trypanosoma cruzi to adapt to different environmental conditions during its life cycle. Posttranscriptional regulation requires association between mRN... | These results indicate that in T. cruzi, as in other eukaryotes, EF-1α may play a non-canonical cellular role. We observed the enrichment of functionally related transcripts bound to EF-1α in normal growth conditions as well as in nutritionally stressed cell indicating a potential role of EF-1α mRNP in stress response. | yes |
25,964,375 | Is early arrival at the emergency department associated with better collaterals , smaller established infarcts and better clinical outcomes with endovascular stroke therapy : SWIFT study? | {
"contexts": [
"Increasing time from symptom onset to emergency department arrival may incur greater ischemic injury and decreased likelihood of good outcomes after acute stroke therapy. The impact of time may be assessed bythe extent of acute CT changes, status of collateral vessels, and clinical outcomes.",
... | Time was a critical factor in successful clinical outcomes for neurothrombectomy in the SWIFT trial. Shorter times to presentation were associated with better collaterals, smaller established infarcts, and better clinical outcome after revascularization. | yes |
25,985,708 | Does the effect of exercise on exhaled nitric oxide depend on allergic rhinoconjunctivitis in children? | {
"contexts": [
"Fractional exhaled nitric oxide (FENO) and exercise testing are widely used for the evaluation of pediatric asthma. The evidence relating to the effects of strenuous exercise on FENO in children is conflicting. Little information is available on the association between exercise and FENO in relati... | The impact of exercise on FENO was dependent on the allergic phenotype, regardless of asthma status. FENO decreased immediately after exercise, and did not return to baseline level within 30 min. | yes |
25,978,802 | Does neonatal DTI early after birth predict motor outcome in preterm infants with periventricular hemorrhagic infarction? | {
"contexts": [
"To determine the association between early neonatal diffusion tensor imaging (DTI) and the development of unilateral spastic cerebral palsy (USCP) in preterm infants with periventricular hemorrhagic infarction (PVHI).",
"Preterm infants with PVHI were assessed with early (≤4 wk after birth) a... | DTI in preterm infants with PVHI within a few weeks after birth is associated with later motor development. | yes |
25,980,764 | Is eDIL3 a novel regulator of epithelial-mesenchymal transition controlling early recurrence of hepatocellular carcinoma? | {
"contexts": [
"Patients with advanced hepatocellular carcinoma (HCC) continue to have a dismal prognosis. Early recurrence, metastases and angiogenesis are the major obstacles to improve the outcome of HCC. Epithelial-mesenchymal transition (EMT) is a key contributor to cancer metastasis and recurrence, which a... | EDIL3-mediated activation of TGF-β and ERK signaling could provide therapeutic implications for HCC. | yes |
25,973,213 | Is mechanical dyssynchrony additive to ECG criteria and independently associated with reverse remodelling and clinical response to cardiac resynchronisation therapy in patients with advanced heart failure? | {
"contexts": [
"QRS duration and morphology are known established predictors of cardiac resynchronisation therapy (CRT) response, whereas mechanical dyssynchrony is not. Our aim was to determine if mechanical dyssynchrony provides independent prognostic information on CRT response.",
"We studied 369 consecut... | Radial dyssynchrony was associated with significant improvements in LVESV and clinical outcomes following CRT and is independent of QRS duration or morphology, and additive to current ECG selection criteria to predict response to CRT. | yes |
25,988,517 | Does the Ohmmeter identify the Site of Fluid Leakage during Artificial Urinary Sphincter Revision Surgery? | {
"contexts": [
"While the AMS 800 artificial urinary sphincter improves continence in up to 90% of patients, revision surgery may be needed in up to 50%. We determined whether an ohmmeter could accurately assess the site of fluid leak from individual components of the artificial urinary sphincter at the time of ... | In cases of suspected fluid loss as a cause of artificial urinary sphincter malfunction an ohmmeter can identify the site of fluid loss during component revision surgery. | yes |
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