pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
25,966,777 | Does mMP13 regulate Aggressiveness of Pediatric Multiple Myeloma Through VEGF-C? | {
"contexts": [
"Even though the blood and lymphatic vascular systems are both involved in the occurrence of cancer metastases, it is believed that lymphatic system is primarily responsible for the initial metastasis. Nevertheless, the molecular mechanisms underlying lymphangiogenesis of multiple myeloma (MM), es... | Since VEGF-C is a well-known growth factor for lymphatic vessels, our data suggest that MMP13 may activate VEGF-C to promote cancer cell metastasis through lymphatic vascular systems in pediatric MM. | yes |
25,975,260 | Do soluble Notch ligand and receptor peptides act antagonistically during angiogenesis? | {
"contexts": [
"Notch signalling is essential for blood vessel formation. During angiogenesis, the Notch ligand DLL4 on the leading tip cell activates Notch receptors on the adjacent stalk cells. DLL4-Notch signalling is impaired by the Notch ligand JAG1 in endothelial cells. The Delta/Serrate/Lag2 (DSL) domain ... | The minimal binding domains of Notch ligands are sufficient to interfere with Notch signalling. The corresponding soluble Notch1 EGF11-13 peptide binds stronger to inhibitory Notch ligands and thereby promotes Notch signalling in endothelial cells. | yes |
25,982,144 | Does 5-Aminolevulinic acid-mediated sonodynamic therapy induce anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis? | {
"contexts": [
"Malignant melanoma is a very refractory skin tumor due to its high metastasis, poor prognosis, and insensitivity to chemotherapy. Sonodynamic therapy has recently evolved as a potential method to treat cancers. In this study, 5-aminolevulinic acid-mediated sonodynamic therapy (ALA-SDT) was used t... | ALA-SDT showed synergistic anti-tumor effects in malignant melanoma by constituting a positive feedback loop of p53-miR-34a-Sirt1 axis. | yes |
25,977,204 | Is methamphetamine injecting associated with phylogenetic clustering of hepatitis C virus infection among street-involved youth in Vancouver , Canada? | {
"contexts": [
"Among prospective cohorts of people who inject drugs (PWID), phylogenetic clustering of HCV infection has been observed. However, the majority of studies have included older PWID, representing distant transmission events. The aim of this study was to investigate phylogenetic clustering of HCV inf... | In this study of street-involved youth with HCV infection and recent injecting, 14% demonstrated phylogenetic clustering. Phylogenetic clustering was associated with recent methamphetamine injection, suggesting that methamphetamine drug injection may play an important role in networks of HCV transmission. | yes |
25,979,847 | Do refractory celiac disease and EATL patients show severe malnutrition and malabsorption at diagnosis? | {
"contexts": [
"Refractory celiac disease type II (RCDII) and EATL (Enteropathy Associated T-cell Lymphoma) are (pre)malignant complications of celiac disease (CD). Data on malnutrition and intestinal absorption is lacking in these patients. Therefore, the aim of the study is to comprehensively assess nutritiona... | The nutritional status of patients with RCDII and EATL is inferior compared with untreated naïve CD patients at presentation. Both malabsorption as well as hypermetabolism contribute to malnutrition. | yes |
25,980,437 | Does ultra-deep targeted sequencing of advanced oral squamous cell carcinoma identify a mutation-based prognostic gene signature? | {
"contexts": [
"Patients with advanced oral squamous cell carcinoma (OSCC) have heterogeneous outcomes that limit the implementation of tailored treatment options. Genetic markers for improved prognostic stratification are eagerly awaited.",
"Herein, next-generation sequencing (NGS) was performed in 345 form... | Genetic variants identified by NGS technology in FFPE samples are clinically useful to predict prognosis in advanced OSCC patients. | yes |
25,980,432 | Does tRPV4 mediate flow-induced increases in intracellular Ca in medullary thick ascending limbs? | {
"contexts": [
"Medullary thick ascending limbs (mTAL) regulate Na balance and therefore blood pressure. We previously showed that cell swelling and luminal flow activates the mechanosensitive channel TRPV4 in mTAL.",
"We hypothesized that TRPV4 mediates flow-induced increases in intracellular Ca (Cai) in ra... | We conclude that flow-induced increases in Cai are mediated primarily by TRPV4 in the rat mTAL. | yes |
25,962,140 | Does temporary dietary iron restriction affect the process of thrombus resolution in a rat model of deep vein thrombosis? | {
"contexts": [
"Deep vein thrombosis (DVT) is a major cause of pulmonary thromboembolism and sudden death. Thus, it is important to consider the pathophysiology of DVT. Recently, iron has been reported to be associated with thrombotic diseases. Hence, in this study, we investigate the effects of dietary iron res... | These results suggest that dietary iron restriction affects the process of thrombus resolution in DVT. | yes |
25,986,167 | Is healthcare workers ' decision-making about transmission-based infection control precautions improved by a guidance summary card? | {
"contexts": [
"Transmission-based precautions (TBPs) are infection control measures designed to interrupt pathogen transmission. Success relies on early recognition of patients with potentially infectious syndromes, then the implementation of appropriate TBPs. We are aware of no literature evaluating interventi... | There is a lack of knowledge about TBP among HCWs. This study demonstrates how an inexpensive TBP summary card is an effective mechanism for improving (i) point-of-care access to TBP guidance and (ii) decision-making about appropriate implementation of TBP. | yes |
25,976,231 | Does overexpression of pyruvate dehydrogenase kinase support dichloroacetate as a candidate for cutaneous melanoma therapy? | {
"contexts": [
"We aimed to verify if there is evidence to consider dichloroacetate (DCA), which inhibits the pyruvate dehydrogenase kinase (PDK) and reverts the metabolic shift of cancer cells from glycolysis to oxidative phosphorylation, as a promising drug for therapy of cutaneous melanoma (CM) patients.",
... | Our results suggest that PDK expression may play a role in melanoma development and that DCA can be useful for CM therapy, alone or in combination with mTOR inhibitors. | yes |
25,964,640 | Are diagnostic delays common among patients with hepatocellular carcinoma? | {
"contexts": [
"Most patients with hepatocellular carcinoma (HCC) present at advanced stages. The prevalence and clinical impact of delays during diagnostic evaluation among patients with HCC is unclear.",
"To identify and characterize factors associated with diagnostic delays among patients with HCC.",
... | Nearly 20% of patients with HCC wait more than 3 months from presentation to diagnosis, which can contribute to interval tumor growth. | yes |
25,973,519 | Is ethanol Modulation Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors? | {
"contexts": [
"Mutagenesis and labeling studies have identified amino acids from the human α1 glycine receptor (GlyR) extracellular, transmembrane (TM), and intracellular domains in mediating ethanol (EtOH) potentiation. However, limited high-resolution structural data for physiologically relevant receptors in ... | Our results are consistent with a TM mechanism of EtOH modulation in Cys-loop receptors. This work highlights the relevance of bacterial homologs as valuable model systems for studying ion channel function of human receptors and demonstrates the modularity of these channels across species. | yes |
25,962,180 | Does miR-138 suppress Cell Proliferation by Targeting Bag-1 in Gallbladder Carcinoma? | {
"contexts": [
"MiR-138 is frequently downregulated in different cancer types and is thought to be involved in the progression of tumorigenesis. However, the molecular mechanism of miR-138 involvement in gallbladder carcinoma still remains unknown.",
"The expression of miR-138 in 49 gallbladder carcinoma sam... | Expression of miR-138 is frequently reduced in gallbladder carcinoma when compared to normal cells. Overexpression of miR-138 inhibited cell proliferation by directly suppressing the expression of Bag-1. These results suggest that miR-138 plays an important role in inhibiting the growth of gallbladder carcinoma. | yes |
25,960,960 | Does excessive iodine intake increase the recurrence rate of graves ' disease after withdrawal of the antithyroid drug in an iodine-replete area? | {
"contexts": [
"The relationship between iodine intake and effects of antithyroid drugs (ATD) for Graves' disease, especially in iodine-deficient areas, has been demonstrated in many studies. However, it was not clear how chronic high iodine intake influenced the effectiveness of ATD in an iodine-replete area. T... | The present study suggests that excessive iodine intake does not have an effect on the clinical outcomes of Graves' disease in an iodine-replete area, and therefore diet control with iodine restriction might not be necessary in the management of Graves' disease. | no |
25,986,908 | Do validation of the Community Integration Questionnaire in the adult burn injury population? | {
"contexts": [
"With improved survival, long-term effects of burn injuries on quality of life, particularly community integration, are important outcomes. This study aims to assess the Community Integration Questionnaire's psychometric properties in the adult burn population.",
"Data were obtained from a mul... | The CIQ-13 demonstrates validity and reliability in the adult burn survivor population addressing issues of self/family care and social integration. This instrument is useful in future research of community reintegration outcomes in the burn population. | yes |
25,981,750 | Is elevated serum monocyte chemoattractant protein-1 levels and its genetic polymorphism associated with diabetic retinopathy in Chinese patients with Type 2 diabetes? | {
"contexts": [
"Previous studies have reported that monocyte chemoattractant protein-1 (MCP-1) is involved in inflammatory and metabolic diseases. The purpose of this study is to investigate the role of MCP-1 in the pathogenesis of diabetic retinopathy (DR) in Han Chinese patients with Type 2 diabetes.",
"Se... | The results suggested that the -2518 GG genotype and G allele of MCP-1 are associated with an increased risk of PDR in the Chinese Han population. This polymorphism may influence the expression of the MCP-1 gene, which may play an important role in the pathogenesis of DR. | yes |
25,964,566 | Does serum Angiopoietin-like Protein 2 improve Preoperative Detection of Lymph Node Metastasis in Colorectal Cancer? | {
"contexts": [
"We investigated whether serum markers and clinical factors could be used to preoperatively predict lymph node (LN) metastasis in colorectal cancer (CRC).",
"The present study enrolled 157 curative CRC patients for whom preoperative serum carcinoembryonic antigen (CEA), systemic inflammatory m... | Serum ANGPTL2 improves preoperative detection of LN metastasis in CRC. | yes |
25,964,568 | Does absolute lymphocyte count with extreme hyperleukocytosis have a prognostic impact in chronic lymphocytic leukemia? | {
"contexts": [
"BACKGROUND/ AIM: The prognostic significance of hyperleukocytosis in chronic lymphocytic leukemia (CLL) remains uncertain. The aim of the present study was to evaluate the clinical characteristics and outcome of patients with CLL and white blood count (WBC) >150×10(6)/l at the time of diagnosis."... | Although our results do not confirm that high initial levels of WBC are independently associated with shorter survival in CLL, the clinical course in these cases appears to be aggressive and conventional prognostic factors are not valid in this patient sub-group. | no |
25,958,641 | Does [ Analysis on 2011 quality control result on aerobic plate count of microbiology laboratories in China ]? | {
"contexts": [
"To test the aerobic plate count examining capability of microbiology laboratories, to ensure the accuracy and comparability of quantitative bacteria examination results, and to improve the quality of monitoring.",
"The 4 different concentration aerobic plate count piece samples were prepared ... | The quality control program has provided scientific data that the aerobic plate count capability of the laboratories meets the requirements of monitoring tasks. | yes |
25,979,485 | Does lenalidomide enhance Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma? | {
"contexts": [
"PD-1/PD-L1 signaling promotes tumor growth while inhibiting effector cell-mediated antitumor immune responses. Here, we assessed the impact of single and dual blockade of PD-1/PD-L1, alone or in combination with lenalidomide, on accessory and immune cell function as well as multiple myeloma cell ... | Our data therefore demonstrate that checkpoint signaling plays an important role in providing the tumor-promoting, immune-suppressive microenvironment in multiple myeloma, and that PD-1/PD-L1 blockade induces anti-multiple myeloma immune response that can be enhanced by lenalidomide, providing the framework for clinica... | yes |
25,973,071 | Is stomatin-like protein 2 expression associated with clinical survival in patients with cervical cancer? | {
"contexts": [
"To investigate the prognostic role of stomatin-like protein 2 (STOML2) in cervical cancer.",
"The expression of STOML2 in 8 pairs of cervical cancer and adjacent normal cervical tissues were detected by Real-time PCR. Immunohistochemistry was performed to evaluation of STOML2 expression in 94... | Our study showed STOML2 was correlated to progression in cervical cancer, and implicated it as a potential predictive factor for the prognosis of cervical cancer. | yes |
25,959,262 | Is a wide QRS/T angle in bundle branch blocks associated with increased risk for coronary heart disease and all-cause mortality in the Atherosclerosis Risk in Communities ( ARIC ) Study? | {
"contexts": [
"Repolarization abnormality in bundle branch blocks (BBB) is traditionally ignored. This study evaluated the prognostic value of QRS/T angle for mortality in the presence and absence of BBB.",
"Total 15,408 participants (mean age 54 years, 55.2% women, 26.9% blacks, 2.8% with BBB) were from th... | A wide spatial QRS/T angle in BBB is associated with increased risk for CHD and all-cause mortality over and above the predictive value for BBB alone. The risk for women is as high as or higher than that in men. | yes |
25,959,381 | Does experimental acute lung injury induce multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction? | {
"contexts": [
"The Tie2/angiopoietin (Tie2/Ang) and vascular endothelial growth factor receptor-ligand systems (VEGFR/VEGF) are recognized to play important roles in the regulation of microvascular endothelial function. Downregulation of these genes during sepsis has been implicated in the pathogenesis of sepsi... | Our results demonstrate that decreases in transcription-permissive, but not increases in transcription-repressive, histone modifications at Angpt1, Tek, and Kdr are a systemic, rather than a lung-restricted, response, involving key end-organs in experimental ALI-sepsis. Given that ventilator-associated pneumonia is a m... | yes |
25,970,160 | Does niclosamide suppress cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition? | {
"contexts": [
"It is known that over expression of IL6 in prostate cancer cells confer enzalutamide resistance and that this may occur through constitutive Stat3 activation. Additionally, recent pre-clinical studies suggested enzalutamide might have the potential adverse effect of inducing metastasis of prostat... | This study demonstrated the IL6-Stat3-AR axis in prostate cancer is one of the crucial mechanisms of enzalutamide resistance. Niclosamide has the potential to target the IL6-Stat3-AR pathway to overcome enzalutamide resistance and inhibit migration and invasion in advanced prostate cancer. | yes |
25,977,388 | Are low vitamin D levels associated with the presence of serum cryoglobulins in patients with chronic HCV infection? | {
"contexts": [
"Mixed Cryoglobulinemia (MC) represents the most frequent extrahepatic manifestation of chronic Hepatitis C Virus (HCV) infection. Its pathogenic mechanisms involve HCV-induced chronic stimulation of B-lymphocytes. We aimed to investigate the relationship between serum levels of vitamin D (a regul... | Severe deficiency of vitamin D was independently associated with mixed cryoglobulinemia in patients with HCV infection. | yes |
25,964,060 | Does treadmill running improve hindlimb arteriolar endothelial function in type 1 diabetic mice as visualized by X-ray microangiography? | {
"contexts": [
"Vascular function is impaired in patients with diabetes, however diabetic vascular dysfunction is ameliorated by exercise training. We aimed to clarify which hindlimb arterial segments are affected by treadmill running in the hindlimbs of streptozocin-induced type 1 diabetic mice in vivo.",
"... | Diabetes impaired acetylcholine-induced vasodilator function locally in the arteries <100 μm diameter and decreased hindlimb vascular conductance responded to acetylcholine, while regular treadmill running significantly ameliorated the impaired vasodilator function, and enhanced the decreased conductance in the diabeti... | yes |
25,959,026 | Does biliopancreatic diversion with duodenal switch modify plasma chemerin in early and late post-operative periods? | {
"contexts": [
"Bariatric surgery remains the most effective treatment for obesity and metabolic syndrome. Surgical benefit arises from early-phase resolution of hyperglycemia and late-phase weight loss. The adipokine chemerin is of interest given its roles in immunity, adipogenesis, and metabolism. The study ob... | Chemerin has a novel role in surgical injury but not hyperglycemia resolution early after BPD-DS. Over the long term, plasma chemerin declines to a new set point that is partially determined by body fat reductions. | yes |
25,970,080 | Does peripheral blood stem cell transplantation improve liver functional reserve? | {
"contexts": [
"Currently available treatment options for decompensated hepatitis B-induced liver cirrhosis are limited and largely ineffective. Recently, stem cell transplantation has emerged as a promising treatment for cirrhosis. The aim of this study was to determine whether autologous peripheral blood stem ... | Autologous peripheral blood stem cell transplantation can improve several markers of liver health and liver functional reserve and is a promising prospect for clinical application. | yes |
25,976,864 | Does the diagnostic value of cerebrospinal fluid chemistry result in childhood tuberculous meningitis? | {
"contexts": [
"Cerebrospinal fluid (CSF) hypoglycorrhachia and elevated protein is well-described in bacterial meningitis, but evidence for its differential diagnostic value in tuberculous meningitis (TBM) is lacking. We aimed to assess the diagnostic utility of CSF glucose, CSF to serum glucose ratio and CSF p... | Absolute CSF glucose values of <2.2 mmol/L and protein values of >1 g/L differentiated between TBM and non-bacterial meningitis with good specificity, although sensitivity was poor. A CSF to serum glucose ratio is more informative than the absolute value. | yes |
25,976,862 | Is adjuvant Chemotherapy and Radiation Therapy Associated with Improved Survival for Patients with Extrahepatic Cholangiocarcinoma? | {
"contexts": [
"This study aimed to analyze adjuvant therapy among patients with extrahepatic cholangiocarcinoma (EHC) at a national level.",
"The American College of Surgeons National Cancer Data Base was used to identify patients with resected EHC (pathologic stages 1-3) between 1998 and 2006 (n = 8741). T... | This national analysis suggests that ACR are associated with improved survival for high-risk EHC patients, such as those with positive lymph nodes. Until randomized clinical trials are conducted, these may be the best available data to guide adjuvant therapy for resected EHC. | yes |
25,967,112 | Does triptolide improve systolic function and myocardial energy metabolism of diabetic cardiomyopathy in streptozotocin-induced diabetic rats? | {
"contexts": [
"Triptolide treatment leads to an improvement in Diabetic Cardiomyopathy (DCM) in streptozotocin-induced diabetic rat model. DCM is characterized by abnormal cardiac energy metabolism. We hypothesized that triptolide ameliorated cardiac metabolic abnormalities in DCM. We proposed (31)P nuclear mag... | (31)P NMR spectroscopy enables assessment of cardiac energy metabolism in whole heart preparations. It detects energy metabolic abnormalities in DCM hearts. Triptolide therapy improves cardiac function and increases cardiac energy metabolism at least partly through upregulation of MAPK signaling transduction. | yes |
25,966,552 | Do [ Allergic factors affect on severity of chronic rhinosinusitis and postoperative outcomes ]? | {
"contexts": [
"To investigate whether the allergic factors impact the severity of chronic rhinosinusitis or not, further more, to explore the relationship between allergic rhinitis and chronic rhinosinusitis.",
"A retrospective review was done on 103 patients. All of these patients were under functional int... | Allergic factor didn't impact much the severity of chronic rhinosinusitis patients who were failed in expectant treatment, besidesthe postoperative outcomes showed that only influence the severity of nasal discharge, facial pressure and loss of smell. Different kinds of allergen were found between the patients of chron... | yes |
25,982,699 | Does magnetic resonance imaging reveal altered distribution of hepatic fat in children with type 1 diabetes compared to controls? | {
"contexts": [
"Children with type 1 diabetes have been identified as a risk group for non-alcoholic fatty liver disease (NAFLD). The aim was to compare total hepatic fat fraction and fat distribution across Couinaud segments in children with type 1 diabetes and controls and the relation of hepatic fat to plasma... | In children with type 1 diabetes, NAFLD may be less common than recent studies have suggested. Children with type 1 diabetes may have a lower fat fraction and a different fat distribution in the liver than controls. Diabetes treatment with MDI or CSII may affect liver fat, but this needs to be confirmed in a larger sam... | yes |
25,978,728 | Do cLINICAL CHARACTERISTICS AND TREATMENT OUTCOMES OF COATS DISEASE IN A SAUDI ARABIAN POPULATION? | {
"contexts": [
"To present the clinical aspects and treatment outcomes of Coats disease in Saudi Arabia.",
"A retrospective chart review was performed of 92 patients (97 eyes) diagnosed with Coats disease at King Khalid Eye Specialist Hospital from 1983 to 2010.",
"The most common presenting complaint wa... | Although rare, Coats disease is usually advanced at presentation and has a poor visual prognosis in the Saudi population, like in other populations. The findings of this study give validity and applicability to the Shields staging scheme, which we recommend using in clinical practice. | yes |
25,965,586 | Does negative Epistasis between Sickle and Foetal Haemoglobin suggest a Reduction in Protection against Malaria? | {
"contexts": [
"Haemoglobin variants, Sickle (HbS) and foetal (HbF) have been associated with malaria protection. This study explores epistatic interactions between HbS and HbF on malaria infection.",
"The study was conducted between March 2004 and December 2013 within the sickle cell disease (SCD) programme... | Higher prevalence of malaria in HbAA compared to HbAS and HbSS confirmed the protective effect of HbS. Lower prevalence of malaria in HbAA with high HbF supports a protective effect of HbF. However, in HbSS, the higher prevalence of malaria with high levels of HbF suggests loss of malaria protection. This is the first ... | yes |
25,962,385 | Does transplantation of human amnion mesenchymal cells attenuate the disease development in rats with collagen-induced arthritis? | {
"contexts": [
"Human amnion mesenchymal cells (hAMCs), isolated from the amniotic membrane of human placenta, are a unique population of mesenchymal stem cells (MSCs). Recent studies indicated that hAMCs had immunosuppressive functions and might be used in treatment of some autoimmune diseases. The aim of this ... | In conclusion, our results indicated that hAMCs could attenuate the disease development in rats with CIA, which might be a promising cell source for therapy of rheumatoid arthritis. | yes |
25,962,506 | Does urolithin A cause p21 up-regulation in prostate cancer cells? | {
"contexts": [
"Walnuts contain several bioactive compounds, including pedunculagin, a polyphenol metabolized by microbiota to form urolithins, namely urolithin A (UA). The aim of this study was to determine gene expression changes in prostate cancer cells after incubation with UA.",
"We performed a genomic ... | Our results indicate a potential role of UA as a chemopreventive agent for prostate cancer. | yes |
25,988,595 | Does prolyl hydroxylase inhibition correct functional iron deficiency and inflammation-induced anaemia in rats? | {
"contexts": [
"Small-molecule inhibitors of prolyl hydroxylase (PHD) enzymes are a novel target for the treatment of anaemia and functional iron deficiency (FID). Other than being orally bioavailable, the differentiation of PHD inhibitors from recombinant human erythropoietin (rhEPO) has not been demonstrated."... | PHD inhibition has a beneficial effect on iron metabolism in addition to stimulating the release of EPO. Small-molecule inhibitors of PHD such as JNJ-42905343 represent a mechanism distinct from rhEPO to treat anaemia and FID. | yes |
25,964,800 | Do a novel population balance model for the dilute acid hydrolysis of hemicellulose? | {
"contexts": [
"Acid hydrolysis is a popular pretreatment for removing hemicellulose from lignocelluloses in order to produce a digestible substrate for enzymatic saccharification. In this work, a novel model for the dilute acid hydrolysis of hemicellulose within sugarcane bagasse is presented and calibrated aga... | The interpretation of kinetic parameters obtained by fitting a model to only a single set of data may be ambiguous. Although these parameters may correctly reproduce the data, they may not be indicative of the actual rate parameters, unless some care has been taken to ensure that the model describes the true mechanisms... | yes |
25,958,919 | Are patients with psoriasis at a higher risk of developing nonalcoholic fatty liver disease? | {
"contexts": [
"Psoriasis is a chronic, immune-mediated inflammatory skin disease with many extracutaneous manifestations. Several recent studies have indicated an increased prevalence of nonalcoholic fatty liver disease (NAFLD) among patients with psoriasis. In the present study, we investigated the prevalence ... | Our findings warrant a detailed assessment of metabolic comorbidities including NAFLD in patients with a primary diagnosis of psoriasis. Lifestyle modifications, including weight loss and smoking cessation, may be necessary for patients with psoriasis to decrease the risk and severity of NAFLD. | yes |
25,961,890 | Is household Food Insecurity Associated with Respiratory Infections Among 6-11-Month Old Infants in Rural Ghana? | {
"contexts": [
"To determine the relationship between household food insecurity (HHFI) and symptoms of respiratory infections among infants in rural Ghana.",
"The study was cross-sectional. The outcome variables were symptoms of respiratory infections (cough and nasal discharge) in infants. HHFI was measured... | Infants living in food insecure households are at an increased risk of respiratory tract morbidity. Interventions that address HHFI might be important to improve infant health in rural Ghana. | yes |
25,977,069 | Is glycA , a biomarker of inflammatory glycoproteins , more closely related to the leptin/adiponectin ratio than to glucose tolerance status? | {
"contexts": [
"Plasma GlycA is a recently developed biomarker whose nuclear magnetic resonance signal originates from glycosylated acute-phase proteins. The aim of our study was to determine potential relationships between GlycA and adiposity, insulin resistance (HOMA(ir)), high sensitive C-reactive protein (hs... | High plasma GlycA reflects a pro-inflammatory state. Adipose tissue-associated inflammatory processes could contribute to increased circulating levels of glycosylated acute-phase proteins. | yes |
25,977,309 | Does activating PPARα prevent post-ischemic contractile dysfunction in hypertrophied neonatal hearts? | {
"contexts": [
"Post-ischemic contractile dysfunction is a contributor to morbidity and mortality after the surgical correction of congenital heart defects in neonatal patients. Pre-existing hypertrophy in the newborn heart can exacerbate these ischemic injuries, which may partly be due to a decreased energy sup... | Stimulating fatty acid β-oxidation in neonatal hearts may present a novel cardioprotective intervention to limit post-ischemic contractile dysfunction. | yes |
25,966,683 | Does lenalidomide reduce microglial activation and behavioral deficits in a transgenic model of Parkinson 's disease? | {
"contexts": [
"Parkinson's disease (PD) is one of the most common causes of dementia and motor deficits in the elderly. PD is characterized by the abnormal accumulation of the synaptic protein alpha-synuclein (α-syn) and degeneration of dopaminergic neurons in substantia nigra, which leads to neurodegeneration ... | These results support the therapeutic potential of lenalidomide for reducing maladaptive neuroinflammation in PD and related neuropathologies. | yes |
25,966,742 | Does ginsenoside rh2 inhibit cancer stem-like cells in skin squamous cell carcinoma? | {
"contexts": [
"Treatments targeting cancer stem cells (CSCs) are most effective cancer therapy, whereas determination of CSCs is challenging. We have recently reported that Lgr5-positive cells are cancer stem cells (CSCs) in human skin squamous cell carcinoma (SCC). Ginsenoside Rh2 (GRh2) has been shown to sign... | Taken together, our data suggest that GRh2 inhibited SCC growth, possibly through reduced the number of Lgr5-positive CSCs. This may be conducted through an interaction between autophagy and β-catenin signaling. | yes |
25,985,244 | Do type 3 Muscarinic Receptors Contribute to Clearance of Citrobacter rodentium? | {
"contexts": [
"The role of muscarinic receptors in mucosal homeostasis, response to enteric pathogens, and modulation of immune cell function is undefined.",
"The contribution of type 3 muscarinic receptors (M3R) to mucosal homeostasis within the colon and host defense against Citrobacter rodentium was dete... | In Chrm3 mice, mucin production is attenuated and is associated with prolonged adherence of C. rodentium to colonic mucosa. The immune response, as characterized by production of TH1/TH17 cytokines, in C. rodentium-infected Chrm3 mice is intact. In addition, M3R activity promotes the development of classically activate... | yes |
25,985,247 | Do low Serum Levels of MicroRNA-19 Are Associated with a Stricturing Crohn 's Disease Phenotype? | {
"contexts": [
"Development of fibrosis and subsequent stricture formation in Crohn's disease (CD) increases morbidity and rates of surgery and reduces patients' quality of life. There are currently no biomarkers of intestinal fibrosis that might allow earlier identification and better management of patients at ... | These data identify miR-19-3p as a potential circulating marker of stricturing CD. Our data show that microRNAs have utility as noninvasive biomarkers of stricturing CD. Further longitudinal studies are required to determine the prognostic value of miR-19-3p at diagnosis. | yes |
25,961,213 | Is nomegestrol acetate an anti-aromatase agent in human MCF-7aro breast cancer cells? | {
"contexts": [
"The progestogen nomegestrol acetate (NOMAC), a 17α-hydroxy-nor-progesterone derivative (LUTENYL®) is largely used as an oral contraceptive and to treat menopausal complaints. In previous studies, we demonstrated that NOMAC is an anti-sulfatase agent in MCF-7 and T-47D breast cancer cells. In this... | The MCF-7aro cell line shows high aromatase activity and NOMAC can act as an anti-aromatase agent by inhibiting this activity. This is an important new effect of this progestogen. Because NOMAC can also inhibit sulfatase activity in breast cancer cells, we suggest that this dual effect of NOMAC has attractive possibili... | yes |
25,985,794 | Does smad3 Signaling promote Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice? | {
"contexts": [
"Heart failure in diabetics is associated with cardiac hypertrophy, fibrosis and diastolic dysfunction. Activation of transforming growth factor-β/Smad3 signaling in the diabetic myocardium may mediate fibrosis and diastolic heart failure, while preserving matrix homeostasis. We hypothesized that ... | Smad3 mediates diabetic cardiac hypertrophy, fibrosis, and diastolic dysfunction, while preserving normal cardiac geometry and maintaining the integrity of the vascular wall. | yes |
25,962,470 | Do elevations of serum CA-125 predict severity of acute appendicitis in males? | {
"contexts": [
"Acute appendicitis (AA) is a common indication for urgent abdominal surgery. CA-125 glycoprotein antigen is a non-specific marker for epithelial ovarian cancer; CA-125 serum levels also increased in the conditions of peritoneal inflammation. The aim of this study was to examine the correlation be... | CA-125 levels correlate with the severity of appendicitis in males and may serve as a surrogate marker for the severity of other intra-abdominal surgical diseases. | yes |
25,981,521 | Is activity of the porcine gonadotropin-releasing hormone receptor gene promoter partially conferred by a distal gonadotrope specific element ( GSE ) within an upstream enhancing region , two proximal GSEs and a retinoid X receptor binding site? | {
"contexts": [
"Regulation of gonadotropin-releasing hormone (GnRH) receptor (GnRHR) numbers on gonadotropes within the anterior pituitary gland represents a critical point for control of reproductive function. Binding of GnRH to its receptor regulates follicle stimulating hormone (FSH) and luteinizing hormone (... | Porcine GnRHR promoter activity in alphaT3-1 cells is partially conferred by a distal GSE, two proximal GSEs and a RXR binding site. Basal gonadotrope expression of the porcine GnRHR gene uniquely involves three GSEs and RXR is newly identified as a regulator of GnRHR promoter activity. | yes |
25,969,699 | Does development of a process to disclose amyloid imaging result to cognitively normal older adult research participants? | {
"contexts": [
"The objective of this study was to develop a process to maximize the safety and effectiveness of disclosing Positron Emission Tomography (PET) amyloid imaging results to cognitively normal older adults participating in Alzheimer's disease secondary prevention studies such as the Anti-Amyloid Trea... | We developed a document for use with potential study participants to describe the process of amyloid imaging and the implications of amyloid imaging results; and a disclosure process with attention to ongoing monitoring of both mood and safety to receive this information. This document and process will be used in the A... | yes |
25,969,696 | Are terminal 18q deletions stabilized by neotelomeres? | {
"contexts": [
"All human chromosomes are capped by tandem repeat (TTAGGG)n sequences that protect them against end-to-end fusion and are essential to chromosomal replication and integrity. Therefore, after a chromosomal breakage, the deleted chromosomes must be stabilized by retaining the telomere or acquiring ... | We found that all six deleted chromosomes sequenced were probably stabilized by the healing mechanism leading to a neotelomere formation. | yes |
25,968,126 | Does the efficacy of a lysine-based dendritic hydrogel differ from those of commercially available tissue sealants and adhesives : an ex vivo study? | {
"contexts": [
"Hemostatic agents, tissue adhesives and sealants may contribute to a reduction in hemorrhage-associated morbidity and mortality. Towards this end, we have recently developed a lysine-based dendritic hydrogel (PEG-LysNH2) that can potentially be used in the management of severe trauma and/or intra... | The efficacy of the PEG-LysNH2 was significantly superior to conventional injury repair methods (sutures) and did not differ from those of commercially available products when sealing small incisions. | no |
25,968,128 | Are pathogenic pathways activated in each major cell type of the glomerulus in the Cd2ap mutant mouse model of focal segmental glomerulosclerosis? | {
"contexts": [
"Mutations in several genes expressed in podocytes, including Cd2ap, have been associated with focal segmental glomerulosclerosis in humans. Mutant mouse models provide an opportunity to better understand the molecular pathology that drives these diseases.",
"In this report we use a battery of... | This study provides a comprehensive analysis of the changing properties of the three cell types of the glomerulus in Cd2ap mutants, identifying activated and repressed pathways and responsible genes, thereby delivering a deeper molecular understanding of this genetic disease. | yes |
25,986,741 | Does olfactory function combined with morphology distinguish Parkinson 's disease? | {
"contexts": [
"This study aimed to examine whether the volume of the olfactory bulbs and tracts (OB & T) on magnetic resonance imaging (MRI) is useful for differentiating Parkinson's disease (PD) from PD-related disorders.",
"The study group comprised 13 patients with PD, 11 with multiple system atrophy (MS... | Although preliminary, these data obtained from a combined morphological and functional evaluation of OB or cardiovascular dysautonomia could be useful for further differential of PD and other PD-related disorders. | yes |
25,986,239 | Does ventilation in situ after cardiac death improve pulmonary grafts exposed to 2 hours of warm ischemia? | {
"contexts": [
"The pulmonary donor pool would increase substantially if lungs could be donated after cardiac death (DCD). There have been ethical and legal obstacles since administration of heparin and cooling has to be done immediately after cardiac death. This study examines whether ventilation of DCD lungs w... | The increase in tolerable warm ischemic time in combination with avoiding heparinization and cooling might facilitate the use of DCD lungs for transplantation. | yes |
25,986,237 | Are aging-related renal injury and inflammation associated with downregulation of Klotho and induction of RIG-I/NF-κB signaling pathway in senescence-accelerated mice? | {
"contexts": [
"The predominant distribution of the antiaging Klotho protein in both the kidneys and brain may point to its essential role in protecting against dysfunction of the kidney-brain axis during the aging process. Our previous study showed that the downregulation of Klotho was involved in aging-related... | The present results suggest that aging-related inflammation and the development of early-stage CKD are likely associated with the downregulation of Klotho and induction of the RIG-I/NF-κB signaling pathway in 12-month-old SAMP8 mice. Moreover, aged SAMP8 mice with cognitive deficits and renal damage may be a potential ... | yes |
25,959,703 | Is broad spectrum psychiatric comorbidity associated with better executive functioning in an inpatient sample of individuals with schizophrenia? | {
"contexts": [
"Individuals with schizophrenia exhibit cognitive deficits but whether these deficits are exacerbated by broad spectrum psychiatric comorbidity (i.e., comorbidity that is inclusive of disorders from different diagnostic categories) is unclear. A broad spectrum approach to psychiatric comorbidity i... | A broad spectrum approach to psychiatric comorbidity can help to account for differences in the executive functioning of individuals with schizophrenia. In clinical settings, individuals with schizophrenia and psychiatric comorbidity may benefit from intervention strategies that capitalize on their relatively higher ex... | yes |
25,977,275 | Does dimethyl Fumarate protect Brain From Damage Produced by Intracerebral Hemorrhage by Mechanism Involving Nrf2? | {
"contexts": [
"Intracerebral hemorrhage (ICH) represents a devastating form of stroke for which there is no effective treatment. This preclinical study was designed to evaluate dimethyl fumarate (DMF), a substance recently approved for the treatment of multiple sclerosis, as therapy for ICH. We hypothesized tha... | A clinically relevant dose of DMF demonstrates potent therapeutic efficacy and impressive 24 h therapeutic window of opportunity. This study merits further evaluation of this compound as potential treatment for ICH in humans. | yes |
25,973,162 | Is the female protective effect in autism spectrum disorder mediated by a single genetic locus? | {
"contexts": [
"A 4:1 male to female sex bias has consistently been observed in autism spectrum disorder (ASD). Epidemiological and genetic studies suggest a female protective effect (FPE) may account for part of this bias; however, the mechanism of such protection is unknown. Quantitative assessment of ASD symp... | The results do not support the hypothesis that the FPE is mediated by a single genetic locus; however, this does not exclude the possibility of multiple genetic loci playing a role in the FPE. | no |
25,973,169 | Do key patterning genes contribute to leg elongation in water striders? | {
"contexts": [
"How adaptive phenotypes are shaped by the action of key developmental genes during ontogeny remains poorly understood. Water striders, a group of hemipteran insects, present a unique example of adaptation to life on the fluid water surface substrate. The group has undergone a set of leg modificat... | Together, our results suggest that key patterning genes contribute to the dramatic elongation of thoracic appendages in water striders. | yes |
25,964,585 | Do phospholipase A2 Group III and Group X Have Opposing Associations with Prognosis in Colorectal Cancer? | {
"contexts": [
"Although secretory phospholipase A2 (sPLA2) has been shown to be involved in various biological processes, its specific roles in sub-types of cancer development remain to be elucidated.",
"We examined the expression of sPLA2 group III (GIII) in 142 patients with colorectal cancer using immuno... | sPLA2GIII expression may be used as a risk factor for lymph node metastasis and a prognostic marker in colorectal cancer. In addition, sPLA2GIII and sPLA2GX may play opposing roles in colorectal carcinogenesis. | yes |
25,963,053 | Do post-radiotherapy prostate biopsies reveal heightened apex positivity relative to other prostate regions sampled? | {
"contexts": [
"Prostate biopsy positivity after radiotherapy (RT) is a significant determinant of eventual biochemical failure. We mapped pre- and post-treatment tumor locations to determine if residual disease is location-dependent.",
"There were 303 patients treated on a randomized hypofractionation trial... | In our experience, persistence of prostate tumor cells after RT increases going from the base to apex. MRI was used in planning and image guidance was performed daily during treatment, so geographic miss of the apex is unlikely. Nonetheless, the pattern observed suggests that attention to apex dosimetry is a priority. | yes |
25,972,323 | Does osteopontin regulate VEGFA and ICAM-1 mRNA Expression in Breast Carcinoma? | {
"contexts": [
"To analyze the regulatory role of osteopontin on biomarkers associated with cell survival, invasiveness, and angiogenesis mechanisms in a clinical series and breast cancer cell lines.",
"We analyzed by quantitative real-time polymerase chain reaction the messenger RNA (mRNA) expression of ost... | Our results support that osteopontin regulates ICAM-1 and VEGFA expression mainly in triple-negative/basal-like breast carcinomas, suggesting a relevant role in the pathogenesis and tumor progression of this molecular subtype. Moreover, VEGFA mRNA levels showed an independent prognostic value in patients with breast ca... | yes |
25,978,446 | Does negative arousal increase the effects of stimulus salience in older adults? | {
"contexts": [
"BACKGROUND/STUDY CONTEXT: Stimuli compete for mental representation, with salient stimuli attracting more attention than less salient stimuli. In a recent study, we found that presenting an emotionally negative arousing sound before briefly showing an array of letters with different levels of sal... | The effects of negative arousal on subsequent attention were similar in older adults as in younger adults. Moreover, the results support arousal-biased competition theory (Mather & Sutherland, 2011, Perspectives on Psychological Science, 6, 114-133), which predicts that emotional arousal amplifies the effects of stimul... | yes |
25,979,712 | Does aggressive Therapy reduce Disease Activity without Skeletal Damage Progression in Chronic Nonbacterial Osteomyelitis? | {
"contexts": [
"To retrospectively assess changes in disease activity and skeletal damage in children with chronic nonbacterial osteomyelitis (CNO) after infliximab and methotrexate, with or without zoledronic acid or nonsteroidal antiinflammatory drug (NSAID) monotherapy, using a standardized magnetic resonance... | An aggressive treatment regimen in CNO improved clinical and imaging measures of disease activity without progression of skeletal damage. | yes |
25,963,798 | Do α-Defensins partially protect human neutrophils against Panton-Valentine leukocidin produced by Staphylococcus aureus? | {
"contexts": [
"α-Defensins produced by neutrophils are important effector molecules of the innate immune system. In addition to their microbicidal effects, α-defensins have the ability to neutralize bacterial toxins. Panton-Valentine leukocidin (PVL) is the hallmark of community-acquired methicillin-resistant S... | Panton-Valentine leukocidin (PVL) is a pore-forming toxin produced by Staphylococcus aureus, responsible for neutrophil damage and key player of severe staphylococcal diseases. Antimicrobial peptides produced by neutrophils (HNP1-3) neutralize several other bacterial cytotoxins. We examined the impact of human neutroph... | yes |
25,964,175 | Does characterization of 1577 primary prostate cancers reveal novel biological and clinicopathologic insights into molecular subtypes? | {
"contexts": [
"Prostate cancer (PCa) molecular subtypes have been defined by essentially mutually exclusive events, including ETS gene fusions (most commonly involving ERG) and SPINK1 overexpression. Clinical assessment may aid in disease stratification, complementing available prognostic tests.",
"To deter... | The m-ERG classifier showed 95% accuracy in an independent validation subset (155 samples). Across cohorts, 45% of PCas were classified as m-ERG(+), 9% as m-ETS(+), 8% as m-SPINK1(+), and 38% as triple negative (m-ERG(-)/m-ETS(-)/m-SPINK1(-)). Gene expression profiling supports three underlying molecularly defined grou... | yes |
25,986,891 | Does miRNA-150 downregulation promote pertuzumab resistance in ovarian cancer cells via AKT activation? | {
"contexts": [
"Pertuzumab is a humanized mAb that binds to the extracellular region of HER2/ErbB2 and is approved for treating breast cancer. Although ovarian cancer and breast cancer have comparable levels of HER2/ErbB2 expression, clinical studies of pertuzumab in epithelial ovarian cancer patients have not m... | miRNA-150 downregulation may contribute to the pertuzumab resistance in ovarian cancer via, at least in part, PI3K-akt pathway. | yes |
25,988,087 | Does cDC42-Interacting Protein 4 Gene be Down Trans-Regulated by HBV DNA polymerase Trans Activated Protein 1? | {
"contexts": [
"Hepatitis B Virus (HBV) DNA polymerase transactivated protein 1 (HBVDNAPTP1) is a novel protein transactivated by HBV DNA polymerase, screened by suppression subtractive hybridization technique (GenBank accession no: AY450389). The biological function of HBVDNAPTP1 was investigated in this study.... | HBVDNAPTP1 may be involved in the positive regulation on the initiation of monocyte apoptosis. The result contribute to reveal the HBVDNAPTP1 biological functions and provide new evidences for further exploration of the regulatory mechanism of HBVDNAPTP1. | yes |
25,988,089 | Do evaluation of cognitive and behavioral effects of peer education model-based intervention to sun safe in children? | {
"contexts": [
"There have been many studies that evidence the health hazards of sunlight exposure, but less study on sun safe intervention model, especially in China. Our aim was to evaluate the cognitive and behavioral effects of a peer education model-based intervention to sun safe in children.",
"Cluster... | Peer education program is somewhat effective in some dimensions for improving children's understanding of sun safe knowledge and behavior. | yes |
25,960,972 | Does short-term Intravenous Antibiotic Treatment in Uncomplicated Diverticulitis Increase the Risk of Recurrence Compared to Long-term Treatment? | {
"contexts": [
"This study included all patients treated at the University Hospital of Geneva for a first episode of uncomplicated diverticulitis. Risks of recurrence and treatment failure were evaluated by comparing the results between short-course and long-course intravenous (IV) antibiotic therapy groups.",
... | Treatment of diverticulitis with a short IV antibiotic treatment is possible and does not modify the recurrence rate in patients with uncomplicated diverticulitis. | no |
25,986,914 | Does high-throughput transcriptomic analysis nominate proteasomal genes as age-specific biomarkers and therapeutic targets in prostate cancer? | {
"contexts": [
"Although prostate cancer (PCa) is hypothesized to differ in nature between younger versus older patients, the underlying molecular distinctions are poorly understood. We hypothesized that high-throughput transcriptomic analysis would elucidate biological differences in PCas arising in younger ver... | Our data show significant global differences in prognostic genes between older versus younger men. We nominate proteasomeal gene expression as an age-specific biomarker and potential therapeutic target specifically in younger men. Limitations of our study include clinical differences between cohorts, and increased como... | yes |
25,963,932 | Does transcutaneous Vagus Nerve Stimulation modulate Default Mode Network in Major Depressive Disorder? | {
"contexts": [
"Depression is the most common form of mental disorder in community and health care settings and current treatments are far from satisfactory. Vagus nerve stimulation (VNS) is a Food and Drug Administration approved somatic treatment for treatment-resistant depression. However, the involvement of ... | tVNS can significantly modulate the DMN FC of MDD patients; our results provide insights to elucidate the brain mechanism of tVNS treatment for MDD patients. | yes |
25,980,330 | Does roux-en-Y gastric bypass attenuate the progression of cardiometabolic complications in obese diabetic rats via alteration in gastrointestinal hormones? | {
"contexts": [
"Roux-en-Y gastric bypass (RYGB) ameliorates type 2 diabetes (T2DM) and obesity through alteration in gastrointestinal (GI) hormones.",
"The objective of this study was to investigate the effect of RYGB on GI hormones and cardiometabolic parameters in Zucker diabetic fatty (ZDF) rodents.",
... | RYGB has beneficial cardiometabolic effects through alterations in GI hormones in a severely obese and diabetic rodent model. | yes |
25,958,168 | Does body mass index predict operative time in elective colorectal procedures? | {
"contexts": [
"Obesity currently affects more than a third of the United States population and is associated with increased surgical complications. Compared to all other subspecialties, colorectal surgery is the most affected by the increasing trend in obese surgical patients. Operative time has been found to h... | BMI, as an objective measure of obesity, is a direct, statistically significant independent predictor of operative time across elective colorectal procedures. | yes |
25,988,129 | Are dietary Patterns Derived Using Exploratory and Confirmatory Factor Analysis Stable and Generalizable Across Race , Region , and Gender Subgroups in the REGARDS Study? | {
"contexts": [
"Examining diet as a whole using dietary patterns as exposures is a complementary method to using single food or nutrients in studies of diet and disease, but the generalizability of intake patterns across race, region, and gender in the United States has not been established.",
"To employ rig... | Five meaningful dietary patterns emerged in the REGARDS study and showed strong congruence across race, sex, and region. Future research will examine associations between these patterns and health outcomes to better understand racial disparities in disease and inform prevention efforts. | yes |
25,978,043 | Is cardiac development in zebrafish and human embryonic stem cells inhibited by exposure to tobacco cigarettes and e-cigarettes? | {
"contexts": [
"Maternal smoking is a risk factor for low birth weight and other adverse developmental outcomes.",
"We sought to determine the impact of standard tobacco cigarettes and e-cigarettes on heart development in vitro and in vivo.",
"Zebrafish (Danio rerio) were used to assess developmental eff... | These data indicate a negative effect of both tobacco cigarettes and e-cigarettes on heart development in vitro and in vivo. Tobacco cigarettes are more toxic than E-cigarettes and exhibit a broader spectrum of cardiac developmental defects. | yes |
25,981,746 | Does clostridium sordellii genome analysis reveal plasmid localized toxin genes encoded within pathogenicity loci? | {
"contexts": [
"Clostridium sordellii can cause severe infections in animals and humans, the latter associated with trauma, toxic shock and often-fatal gynaecological infections. Strains can produce two large clostridial cytotoxins (LCCs), TcsL and TcsH, related to those produced by Clostridium difficile, Clostr... | Genome analysis of C. sordellii reveals that the LCCs, the major virulence factors, are localised on plasmids. Many strains do not contain the LCC genes; it is probable that in several of these cases the plasmid has been lost upon laboratory subculture. Our data are consistent with LCCs being the primary virulence fact... | yes |
25,979,621 | Does chronic Cigarette Smoking in Healthy Middle-Aged Individuals be Associated With Decreased Regional Brain N-acetylaspartate and Glutamate Levels? | {
"contexts": [
"Cigarette smoking is associated with metabolite abnormalities in anterior brain regions, but it is unclear if these abnormalities are apparent in other regions. Additionally, relationships between regional brain metabolite levels and measures of decision making, risk taking, and impulsivity in sm... | This study provides additional novel evidence that chronic smoking in young and middle-aged individuals is associated with significant age-related neurobiological abnormalities in anterior frontal regions implicated in the development and maintenance of addictive disorders. | yes |
25,963,088 | Do esophageal Squamous Cell Carcinoma Patients Have an Increased Risk of Coexisting Colorectal Neoplasms? | {
"contexts": [
"Esophageal squamous cell carcinoma (ESCC) and colorectal neoplasms (CRNs) share risk factors. We aimed to investigate whether the CRN risk is increased in ESCC patients.",
"ESCC patients who underwent a colonoscopy within 1 year of diagnosis were retrospectively analyzed. Patients were matche... | The rates of CRN and advanced CRN are significantly increased in ESCC. Colonoscopy should be considered at ESCC diagnosis. | yes |
25,976,768 | Does serum chemokine network correlate with chemotherapy in non-small cell lung cancer? | {
"contexts": [
"Inflammation plays an important role in the microenvironment of lung cancer. The present study aimed to evaluate the association of inflammatory biomarker networks with chemotherapies for patients with non-small cell lung cancer (NSCLC).",
"The sera of healthy non-smokers (n = 14) and patient... | Our data identify an NSCLC-specific profile of inflammatory mediators that may be useful for cancer sub-classification, as well as the evaluation of therapeutic effects and overall survival. | yes |
25,965,611 | Does prolonged right ventricular ejection delay identify high risk patients and gender differences in Brugada syndrome? | {
"contexts": [
"Right ventricular (RV) conduction delay has been suggested as an underlying pathophysiological mechanism in Brugada syndrome (BS). In this cross-sectional study we non-invasively assessed the value of echocardiographic markers reflecting ventricular ejection delay to further assess electromechani... | We demonstrated that a previous history of malignant events was associated with longer RVEDs. Our findings supported the RV conduction delay mechanism behind BS and demonstrated for the first time that the predominant malignant male Brugada phenotype might also be the result of a more delayed RV conduction in males. | yes |
25,984,529 | Do human Umbilical Cord Mesenchymal Stem Cells Inhibit the Function of Allogeneic Activated Vγ9Vδ2 T Lymphocytes In Vitro? | {
"contexts": [
"Human umbilical cord mesenchymal stem cells (UC-MSCs) can regulate the function of immune cells. However, whether and how UC-MSCs can modulate the function of Vγ9Vδ2 T cells has not been fully understood.",
"The PBMCs or Vγ9Vδ2 T cells were activated and expanded with pamidronate (PAM) and in... | These results indicated that UC-MSCs efficiently suppressed the proliferation and cytotoxicity of Vγ9Vδ2 T cells and modulated their cytokine production. Fas-L and TRAIL were involved in the regulation. Cell contact and apoptosis of Vγ9Vδ2 T cells were not necessary for the inhibition. | yes |
25,973,068 | Is lgr5 a potential prognostic marker in patients with cervical carcinoma? | {
"contexts": [
"To investigate the Lgr5 (Leucine-rich repeat-containing G protein-coupled receptor 5) expression in cervical carcinoma and to estimate its clinical significance.",
"The expression of Lgr5 mRNA was evaluated by Real-time PCR in 8 pairs of surgically removed cervical cancer and adjacent normal ... | Lgr5 may play an important role in the development and progression of cervical carcinoma, and may be a potential therapeutic target for the treatment of cervical carcinoma. | yes |
25,963,233 | Does exercise capacity independently predict bone mineral density and proximal femoral geometry in patients with acute decompensated heart failure? | {
"contexts": [
"Heart failure is associated with increased risk of osteoporosis. We evaluated the prevalence and predictors of osteoporosis in hospitalized patients with ADHF using quantitative computed tomography. Osteoporosis and vertebral fracture are prevalent in patients with ADHF and exercise capacity inde... | In male patients with ADHF, osteoporosis and vertebral fracture are prevalent, and exercise capacity independently predicts bone mass and geometry. Given that heart failure patients with reduced exercise capacity carry a substantial increased risk of fracture, proper osteoporosis evaluation is important in these patien... | yes |
25,971,889 | Does quercetin inhibit HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion? | {
"contexts": [
"Melanoma is notorious for its propensity to metastasize, which makes treatment extremely difficult. Receptor tyrosine kinase c-Met is activated in human melanoma and is involved in melanoma progression and metastasis. Hepatocyte growth factor (HGF)-mediated activation of c-Met signaling has been ... | Our findings suggest that suppression of the HGF/c-Met signaling pathway contributes to the anti-metastatic action of quercetin in melanoma. | yes |
25,985,729 | Are lipoprotein ratios better than conventional lipid parameters in predicting coronary heart disease in Chinese Han people? | {
"contexts": [
"Dyslipidaemia is the main risk factor for coronary heart disease (CHD). Plasma lipid levels are conven-tionally used to predict coronary risk globally, but further studies are required to investigate whether the lipoprotein ratios are superior to conventional lipid parameters as predictors for CH... | Our data indicate that the lipoprotein ratios are superior to conventional lipid parameters as predictors for CHD. Of the ratios, apoB100/apoAI is the best to predict CHD risk. | yes |
25,962,727 | Does transcriptomic analysis of wheat near-isogenic lines identify PM19-A1 and A2 as candidates for a major dormancy QTL? | {
"contexts": [
"Next-generation sequencing technologies provide new opportunities to identify the genetic components responsible for trait variation. However, in species with large polyploid genomes, such as bread wheat, the ability to rapidly identify genes underlying quantitative trait loci (QTL) remains non-t... | The efficient identification of these strong candidates demonstrates the utility of our transcriptomic pipeline for rapid QTL to gene mapping. By using this approach we are able to provide a comprehensive genetic analysis of the major source of grain dormancy in wheat. Further analysis across a diverse panel of bread a... | yes |
25,973,233 | Does elevated expression of USP9X correlate with poor prognosis in human non-small cell lung cancer? | {
"contexts": [
"The aim of this study was to investigate the expression of ubiquitin-specific peptidase 9, X-linked (USP9X) in non-small cell lung cancer (NSCLC) patients and to evaluate the relevance of USP9X expression to tumor prognosis.",
"Ninety-five patients who underwent surgical resection for clinica... | The current study demonstrated that the expression of USP9X in NSCLC tissue was significantly higher than that in normal lung tissue and that this elevated expression level of USP9X was associated with poor prognosis among NSCLC patients, suggesting that USP9X might serve as a prognostic biomarker for NSCLC. | yes |
25,964,208 | Does prehospital oral chlorhexidine reduce the rate of ventilator-associated pneumonia among critically ill trauma patients : A prospective concurrent-control study? | {
"contexts": [
"The purpose of the study was to test the hypothesis that prehospital oral chlorhexidine administered to intubated trauma patients will decrease the Clinical Pulmonary Infection Score (CPIS) during the first 2 days of hospitalization.",
"Prospective interventional concurrent-control study of a... | The prehospital administration of oral chlorhexidine does not reduce the CPIS score over the first 48 hours of admission for intubated trauma patients. Further study should explore other prehospital strategies of reducing complications of critical illness. | no |
25,967,575 | Does perivascular adipose adiponectin correlate with symptom status of patients undergoing carotid endarterectomy? | {
"contexts": [
"Recent symptoms stand as a major determinant of stroke risk in patients with carotid stenosis, likely reflective of atherosclerotic plaque destabilization. In view of emerging links between vascular and adipose biology, we hypothesized that human perivascular adipose characteristics associate wit... | Symptomatic and asymptomatic carotid endarterectomy patients display a tissue-specific difference in perivascular adipose adiponectin. This difference, which was not seen in plasma or subcutaneous compartments, supports a potential local paracrine relationship with vascular disease processes that may be related to stro... | yes |
25,964,227 | Are racial minorities more likely than whites to report lack of provider recommendation for colon cancer screening? | {
"contexts": [
"Although screening for colorectal cancer (CRC) is recommended for all adults aged 50 to 75 years in the United States, there are racial and ethnic disparities in who receives screening. Individuals lacking appropriate CRC screening cite various reasons for nonadherence, including lack of provider... | Racial minorities are less likely than whites to receive a physician recommendation for CRC screening. Future research should evaluate why race appears to influence provider recommendations to pursue CRC screening; this is an important step to reduce disparities in CRC screening and lessen the burden of CRC in the Unit... | yes |
25,964,224 | Does rectosigmoid Localization of Radiopaque Markers Correlate with Prolonged Balloon Expulsion in Chronic Constipation : Results from a Multicenter Cohort? | {
"contexts": [
"Ingestion of radiopaque markers (ROMs) is a common means of assessing colonic transit time in chronic constipation. Because anorectal manometry (ARM) testing for pelvic floor dysfunction is mostly limited to academic centers, clinicians frequently use rectosigmoid accumulation of markers as a sur... | Among patients with chronic constipation undergoing ROM transit testing, there is no association between rectosigmoid location of markers and rectoanal gradient or prolonged balloon expulsion. | no |
25,964,223 | Does pNPLA3 Gene Polymorphism be Associated With Predisposition to and Severity of Alcoholic Liver Disease? | {
"contexts": [
"The genetic polymorphism with an isoleucine-to-methionine substitution at position 148 (rs738409 C>G) in the patatin-like phospholipase domain protein 3 (PNPLA3) gene confers risk of steatosis. PNPLA3 polymorphism is shown to be associated with alcoholic liver disease (ALD). We performed a system... | PNPLA3 genetic polymorphism (rs738409 C>G) is associated with increased risk for the entire spectrum of ALD among drinkers including ALI, AC, and HCC. Studies are needed to clarify association of PNPLA3 polymorphism and steatosis in alcoholics. PNPLA3 gene may potentially be a therapeutic target in ALD. | yes |
25,968,954 | Does antioxidant metallothionein alleviate endoplasmic reticulum stress-induced myocardial apoptosis and contractile dysfunction? | {
"contexts": [
"Endoplasmic reticulum (ER) stress exerts myocardial oxidative stress, apoptosis, and contractile anomalies, although the precise interplay between ER stress and apoptosis remains elusive. This study was designed to examine the impact of the cysteine-rich free radical scavenger metallothionein on ... | Taken together, our data favor a beneficial effect of metallothionein against ER stress-induced cardiac dysfunction possibly associated with attenuation of myocardial apoptosis. | yes |
25,976,904 | Are asymptomatic ventricular premature depolarizations necessarily benign? | {
"contexts": [
"Most patients with idiopathic ventricular premature depolarizations (VPDs) complain of symptoms related to this arrhythmia, but some patients are asymptomatic even with a high VPD burden. Our understanding of the relationship between symptoms and cardiomyopathy related to this arrhythmia remains ... | The absence of typical VPD-related symptoms may be a risk factor for cardiomyopathy and be associated with an adverse outcome. | no |
25,961,573 | Does human TM9SF4 be a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells? | {
"contexts": [
"The transmembrane 9 superfamily protein member 4, TM9SF4, belongs to the TM9SF family of proteins highly conserved through evolution. TM9SF4 homologs, previously identified in many different species, were mainly involved in cellular adhesion, innate immunity and phagocytosis. In human, the functi... | Altogether, our study reports for the first time the expression of TM9SF4 at the level of normal and leukemic hematopoietic cells and its marked expression at the level of AMLs displaying granulocytic differentiation. | yes |
25,960,137 | Is surname-inferred Andean ancestry associated with child stature and limb lengths at high altitude in Peru , but not at sea level? | {
"contexts": [
"Native Andean ancestry gives partial protection from reduced birthweight at high altitude in the Andes compared with European ancestry. Whether Andean ancestry is also associated with body proportions and greater postnatal body size at altitude is unknown. Therefore, we tested whether a greater p... | Greater Andean ancestry is associated with shorter stature and limb measurements at high but not low altitude. Gene-environment interactions between high altitude and Andean ancestry may exacerbate the trade-off between chest dimensions and stature that was proposed previously, though we could not test this directly. | yes |
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