pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
25,967,142 | Does tLR9-Targeted STAT3 Silencing abrogate Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients? | {
"contexts": [
"Recent advances in immunotherapy of advanced human cancers underscored the need to address and eliminate tumor immune evasion. The myeloid-derived suppressor cells (MDSC) are important inhibitors of T-cell responses in solid tumors, such as prostate cancers. However, targeting MDSCs proved challe... | Overall, we demonstrate the accumulation of granulocytic MDSCs with prostate cancer progression and the feasibility of using TLR9-targeted STAT3siRNA delivery strategy to alleviate MDSC-mediated immunosuppression. | yes |
25,967,144 | Does vaccination with Melanoma Helper Peptides induce Antibody Responses Associated with Improved Overall Survival? | {
"contexts": [
"A melanoma vaccine incorporating six peptides designed to induce helper T-cell responses to melanoma antigens has induced Th1-dominant CD4(+) T-cell responses in most patients, and induced durable clinical responses or stable disease in 24% of evaluable patients. The present study tested whether ... | Vaccination with helper peptides induced both Ab responses and T-cell responses, associated with favorable clinical outcome. Such immune responses may predict favorable clinical outcome to guide combination immunotherapy. Further studies are warranted to understand mechanisms of interaction of these Abs, T-cell respons... | yes |
25,974,844 | Are clinical Operations Variables Associated With Blood Pressure Outcomes? | {
"contexts": [
"Uncontrolled blood pressure (BP), among patients diagnosed and treated for the condition, remains an important clinical challenge; aspects of clinical operations could potentially be adjusted if they were associated with better outcomes.",
"To assess clinical operations factors' effects on no... | Findings suggest that clinical operations factors can affect clinical outcomes like BP normalization, and point to the importance of considering outcome effects when organizing clinical care. | yes |
25,960,713 | Does beta-Chemokine CCL15 affect the Adhesion and Migration of Hematopoietic Progenitor Cells? | {
"contexts": [
"Hematopoietic stem and progenitor cell (HPC) motility is essential for HPC transplantation. The chemokine CXCL12 is key for HPC motility. Further regulators are of interest to improve HPC transplantation and regenerative medicine. Here the impact of the human chemokine CCL15 on HPC motility was i... | Our results point to a regulation of HPCs by CCL15 by modulating migratory and adhesive properties of HPCs with the potency to improve HPC short-term engraftment in stem cell transplantation. | yes |
25,965,299 | Does redox signalling to nuclear regulatory proteins by reactive oxygen species contribute to oestrogen-induced growth of breast cancer cells? | {
"contexts": [
"17β-Oestradiol (E2)-induced reactive oxygen species (ROS) have been implicated in regulating the growth of breast cancer cells. However, the underlying mechanism of this is not clear. Here we show how ROS through a novel redox signalling pathway involving nuclear respiratory factor-1 (NRF-1) and ... | Taken together, our results present evidence in the support of E2-induced ROS-mediated AKT signalling leading to the activation of NRF-1-regulated cell cycle genes as well as the impairment of p27 activity, which is presumably necessary for the growth of MCF-7 cells. These observations are important because they provid... | yes |
25,961,620 | Does influence of polyurethane resin die on the fit and adaptation of full veneer crowns? | {
"contexts": [
"Polyurethane resin is a possible alternative to type IV dental stone for fabrication of indirect restorations however its dimensional accuracy is questionable.",
"The aim was to investigate the dimensional accuracy of silica filled polyurethane resin die material by evaluating the marginal fi... | The fit and adaptation of indirect gold castings made on polyurethane and type IV dental stone dies were comparable. | yes |
25,961,192 | Are preoperative low serum testosterone levels associated with tumor aggressiveness in radical prostatectomy treated cancer patients? | {
"contexts": [
"The aim of this study was to characterize the aggressiveness of prostate cancer as assessed by the Gleason score (GS), the predominant Gleason pattern (pGP), and testosterone (T) serum concentration.",
"A total of 247 patients, referred to our Department (from January 2007 to December 2009) f... | Aggressiveness of the tumor cannot be properly estimated by the GS and pGP found in biopsies. The pGP in prostate specimens is of paramount importance, particularly in the case of a Gleason 7, to appreciate the outcomes and to choose the treatment. Preoperative testosterone should be added to PSA determination to impro... | yes |
25,978,953 | Does an 8-O-4 ' norlignan exert oestrogen-like actions in osteoblastic cells via rapid nongenomic ER signaling pathway? | {
"contexts": [
"Sambucus williamsii Hance (SWH), which belongs to the Caprifoliaceae family distributed in various regions of China, Korea and Japan, has been used as a folk medicine for treatment of bone and joint diseases in China for thousands of years. In previous studies, SWH was shown to possess anti-osteo... | These data show that PPD is a bioactive compound in SWH that exerts oestrogen-like actions in osteoblast-like cells via ligand-independent, estrogen response element (ERE)-independent and mitogen-activated protein (MAP) Kinase-mediated rapid nongenomic ER signaling pathway. | yes |
25,978,952 | Does aqueous extract of Orostachys japonicus A. Berger exert immunostimulatory activity in RAW 264.7 macrophages? | {
"contexts": [
"Orostachys japonicus A. Berger (Crassulaceae) (OJ), well-known as Wa-song in Korea is a medicinal plant with immunoregulatory, anti-febrile, antidote, and anti-cancer activities. This study was aimed at evaluating the immunostimulatory effect of O. japonicus A. Berger and its possible mechanisms ... | OJ aqueous extract might play a pivotal ethnopharmacologic role as an immunostimulatory agent by promoting Fc gamma receptor (FcγR)-mediated phagocytosis of IgG-opsonized RBCs. On the basis of our results, OJ aqueous extract can enhance innate immunity and may serve as an adjuvant for tumor treatment. | yes |
25,962,653 | Does post t-PA transfer to hub improve outcome of moderate to severe ischemic stroke patients? | {
"contexts": [
"Telemedicine offers rural hospitals the ability to treat acute ischemic stroke on site with intravenous tissue plasminogen activator (t-PA). Most patients are subsequently transferred to a hub hospital with a primary stroke center for post t-PA care. There is little evidence that such transfer is... | Patients with moderate to severe ischemic strokes who were treated with t-PA in a telestroke network may potentially benefit from expert care at a primary stroke center. | yes |
25,962,652 | Is telephone-based low intensity therapy after crisis presentations to the emergency department associated with improved outcomes? | {
"contexts": [
"In Australia there is an overwhelming need to provide effective treatment to patients presenting to the Emergency Department (ED) in mental health crisis. We adapted Improving Access to Psychological Therapies service model (IAPT) from the National Health Service (NHS) method for the large scale ... | The Australian ED IAPT program demonstrated that the UK IAPT program could be adapted for emergency mental health patients and be associated with similar clinical benefits as the original program. | yes |
25,988,561 | Does short Sleep Duration be Related to Emerging Cardiovascular Risk Factors in Obese Children? | {
"contexts": [
"The aim of the present study was to evaluate the influence of sleep duration on cardiovascular risk factors in obese children.",
"Cross-sectional analysis of 90 obese children ages 7 to 16 years. Anthropometric and clinical evaluation with specification of dietary and lifestyle habits was car... | Short sleep duration increases the severity of obesity and is related to cardiovascular risk factors in children. | yes |
25,971,780 | Is reductions in behavioral deficits and neuropathology in the R6/2 mouse model of Huntington 's disease following transplantation of bone-marrow-derived mesenchymal stem cells dependent on passage number? | {
"contexts": [
"Huntington's disease (HD) is an autosomal dominant disorder caused by an expanded CAG repeat (greater than 38) on the short arm of chromosome 4, resulting in loss and dysfunction of neurons in the neostriatum and cortex, leading to cognitive decline, motor dysfunction, and death, typically occurr... | The results from this study demonstrate that BM MSCs hold significant therapeutic value for HD, and that the amount of time the cells are exposed to in vitro culture conditions can alter their efficacy. | yes |
25,967,603 | Does whole-Slide Imaging of Pap Cellblock Preparations be a Potentially Valid Screening Method? | {
"contexts": [
"To date, the impact of digital imaging on routine cytology remains far from perfect. Cellblock (CB) preparations from Pap samples have been shown to be diagnostically valuable. We evaluated the validity of utilizing whole-slide imaging (WSI) prepared from Pap CBs as a screening tool.",
"A tot... | WSI of CB preparations is a feasible method to achieve high-quality specimen preparations. It is as sensitive as liquid-based methods and appears to be highly specific for the detection of LSIL and HSIL. | yes |
25,970,336 | Is vitamin D deficiency at melanoma diagnosis associated with higher Breslow thickness? | {
"contexts": [
"Epidemiological evidence shows that people with thicker, or higher stage, melanomas have lower vitamin D status compared to those with thinner tumours. Evidence from experimental studies is inconsistent, but some suggest that administration of vitamin D metabolites can decrease tumour aggressiven... | Vitamin D deficiency at the time of melanoma diagnosis is associated with thicker tumours that are likely to have a poorer prognosis. Ensuring vitamin D levels of 50 nmol/L or higher in this population could potentially result in 18% of melanomas having Breslow thickness of <0.75 mm rather than ≥0.75 mm. | yes |
25,970,707 | Does oxygenation decrease elastin secretion from rat ductus arteriosus smooth muscle cells? | {
"contexts": [
"The ductus arteriosus (DA), a fetal arterial connection between the main pulmonary artery and the descending aorta, normally closes immediately after birth. The oxygen concentration in the blood rises after birth, and in the DA this increase in oxygen concentration causes functional closure, whic... | Given that elastin forms internal elastic lamina and elastic fibers in the vascular muscle layers, and that a rise in oxygen concentration reduced the secretion of elastin, this suggests that the rise in blood oxygen concentration after birth reduces the secretion of elastin, and therefore may play a role in DA structu... | yes |
25,988,358 | Does advanced fibrosis associate with atherosclerosis in subjects with nonalcoholic fatty liver disease? | {
"contexts": [
"Nonalcoholic fatty liver (NAFLD) with advanced fibrosis usually has a deteriorated prognosis, which was mainly attributed to cardiovascular cause. We investigated whether advanced fibrosis assessed by noninvasive fibrosis markers was associated with subclinical atherosclerosis in NAFLD patients."... | Advanced fibrosis indicated by NFS was positively associated with CIMT, presence of carotid plaque and arterial stiffness in the NAFLD patients, independent of conventional cardiometabolic risk factors and insulin resistance. | yes |
25,960,044 | Are enteric glial cells associated with stress-induced colonic hyper-contraction in maternally separated rats? | {
"contexts": [
"Enteric glial cells (EGCs) play important roles in enteric integrity and regulation of gastrointestinal function. However, whether EGCs undergo pathophysiological changes in stress-associated gastrointestinal disorders is unknown. We investigated structural and functional alterations in colonic E... | Colonic EGCs exhibited structural alterations according to the stress intensity. EGCs were associated with stress-induced colonic hyper-contraction in the combined stress rats, which may underlie the pathogenesis of IBS. | yes |
25,963,634 | Does electroacupuncture inhibit weight gain in diet-induced obese rats by activating hypothalamic LKB1-AMPK signaling? | {
"contexts": [
"Electroacupuncture (EA) is reported to be an effective treatment for obesity, but its mechanism is unclear. This study aimed to investigate the relationship between hypothalamic LKB1-AMPK-ACC signaling and EA.",
"Fifty male Sprague-Dawley rats were divided into two groups fed either chow (cho... | This study suggests that hypothalamic LKB1-AMPK-ACC signaling plays an important role in EA treatment for obesity. | yes |
25,979,862 | Does oxygen Tension regulate Human Mesenchymal Stem Cell Paracrine Functions? | {
"contexts": [
": Mesenchymal stem cells (MSCs) have captured the attention and research endeavors of the scientific world because of their differentiation potential. However, there is accumulating evidence suggesting that the beneficial effects of MSCs are predominantly due to the multitude of bioactive mediato... | The present study investigated and characterized select aspects of the human mesenchymal stem cell (hMSC) secretome and assessed its in vitro and in vivo biological bioactivity as a function of oxygen tension, specifically near anoxia (0.1% O2) and hypoxia (5% O2), conditions that reflect the environment to which MSCs ... | yes |
25,977,381 | Does β-Glucan from Saccharomyces cerevisiae induce IFN-γ Production In Vivo in BALB/c Mice? | {
"contexts": [
"β-Glucan is one of the most abundant polymers in nature and has been established as an immunomodulator. This compound has notable physiological effects on mammalian immune systems, including anti-tumor and anti-infective activities and can activate the immune response. It is considered that the i... | IFN-γ plays an important role in immunity against viral and bacterial infections. Our experiments have shown that β-glucan preparations enhance IFN-γ production in BALB/c mice and can be potentially used for immune system stimulation in mammals. Current results may be used to develop soluble β-glucan nutritional supple... | yes |
25,960,769 | Does cigarette smoking worsen systemic inflammation in persons with metabolic syndrome? | {
"contexts": [
"Emerging data suggests that the combination of smoking and metabolic syndrome (MetS) markedly increases cardiovascular disease risk well beyond that of either condition. In this study we assess if this interaction can be explained by an additive increase in the risk of systemic inflammation by Me... | The study demonstrates an additive effect of cigarette smoking on the risk of systemic inflammation in MetS thus highlighting the need for determining smoking status among those with MetS and aggressively targeting smoking cessation in this population. | yes |
25,977,936 | Are hippocampal volume and depressive symptoms linked to serum IL-18 in schizophrenia? | {
"contexts": [
"Since schizophrenia (SCZ) is often accompanied by hippocampal abnormalities and dysregulation of cytokine production, this study aimed to investigate the impact of the cytokine interleukin (IL)-18, whose biological system appears to be perturbed in SCZ, on brain structure and clinical severity in... | These findings demonstrate that the levels of circulating bioactive IL-18 are related to both hippocampal volume and severity of psychopathologic symptoms in patients with SCZ, confirming the involvement of the cytokine in SCZ pathophysiology and suggesting hippocampal-dependent and neuroprotective functions of IL-18 i... | yes |
25,977,934 | Do αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features? | {
"contexts": [
"To characterize phenotypes of T cells that accumulated in multiple sclerosis (MS) lesions, to compare the lesional T-cell receptor (TCR) repertoire of T-cell subsets to peripheral blood, and to identify paired α and β chains from single CD8(+) T cells from an index patient who we followed for 18 ... | Our observation that a massively expanded TCR Vβ1-Jβ2.3 chain paired with distinct yet closely related canonical or atypical MAIT cell-related α chains strongly points to an antigen-driven process in early active MS brain lesions. | yes |
25,981,372 | Does the duodenal glucose load impact the oral disposition index in healthy subjects? | {
"contexts": [
"In healthy subjects, the oral disposition index (ratio of insulin response to insulin sensitivity) is predictive of the development of Type 2 diabetes. Gastric emptying, which exhibits a substantial interindividual variation, is a major determinant of postprandial glycaemia in health and diabetes... | The rate of duodenal glucose delivery has a major impact on insulin release and, thereby, DI. This suggests that the rate of gastric emptying, which determines duodenal glucose delivery, is a determinant of DI. | yes |
25,984,353 | Is higher BMI associated with reduced brain volume in heart failure? | {
"contexts": [
"Heart failure (HF) patients are at risk for structural brain changes due to cerebral hypoperfusion. Past work shows obesity is linked with reduced cerebral blood flow and associated with brain atrophy in healthy individuals, although its effects on the brain in HF are unclear. This study examined... | Our findings suggest increased BMI negatively affects brain volume in HF, and higher BMI interacts with cerebral perfusion to impact gray matter volume. The mechanisms for these findings remain unclear and likely involve multiple physiological processes. Prospective studies are needed to elucidate the exact pattern and... | yes |
25,987,076 | Are radioactive seed implantation and lobaplatin chemotherapy safe and effective in treating patients with advanced lung cancer? | {
"contexts": [
"Objecive: To investigate the clinical safety and efficacy of CT-guided 125iodine (125I) seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol in treating patients with advanced lung cancer.",
"Patients with advanced lung cancer ... | CT-guided 125I seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol are safe and effective in treating patients with advanced lung cancer. | yes |
25,982,481 | Does single-dose local simvastatin injection improve implant fixation via increased angiogenesis and bone formation in an ovariectomized rat model? | {
"contexts": [
"Statins have been reported to promote bone formation. However, taken orally, their bioavailability is low to the bones. Implant therapies require a local repair response, topical application of osteoinductive agents, or biomaterials that promote implant fixation.",
"The present study evaluate... | A single local injection of simvastatin significantly increased bone formation, promoted osseointegration, and enhanced implant fixation in ovariectomized rats. The underlying mechanism appears to involve enhanced BMP2 expression and angiogenesis in the target bone. | yes |
25,987,505 | Is endolymphatic hydrops prevalent in the first weeks following cochlear implantation? | {
"contexts": [
"To explore morphological or electrophysiological evidence for the presence of endolymphatic hydrops (EH) in guinea pig cochleae in the first 3 months after cochlear implantation.",
"Dummy silastic electrodes were implanted atraumatically into the basal turn of scala tympani via a cochleostomy... | EH is prevalent in the first weeks after implant surgery, even in the absence of significant electrode insertion trauma. | yes |
25,973,080 | Is nuclear C-MYC expression level associated with disease progression and potentially predictive of two year overall survival in prostate cancer? | {
"contexts": [
"Upregulation of nuclear C-MYC protein has been reported to be an early event in prostate cancer (PCa); however, its clinicopathological and prognostic significance remain controversial. We determined the association of nuclear C-MYC protein expression with clinicopathological parameters, prognosi... | Nuclear C-MYC overexpression may be associated with disease progression and potentially predictive of 2-year OS in PCa. This is the first study to demonstrate an association between nuclear C-MYC immunostaining and TMPRSS2-ERG status in PCa. | yes |
25,987,965 | Is advanced glycation end-product expression upregulated in the gastrointestinal tract of type 2 diabetic rats? | {
"contexts": [
"To investigate changes in advanced glycation end products (AGEs) and their receptor (RAGE) expression in the gastrointestinal (GI) tract in type 2 diabetic rats.",
"Eight inherited type 2 diabetic rats Goto-Kakizak (GK) and ten age-matched normal rats were used in the study. From 18 wk of age... | The AGE and RAGE expression was up-regulated in the GI tract of GK diabetic rats and may contribute to GI dysfunction in type 2 diabetic patients. | yes |
25,965,962 | Do k ( V ) 7.4 channels participate in the control of rodent renal vascular resting tone? | {
"contexts": [
"We tested the hypothesis that K(V)7 channels contribute to basal renal vascular tone and that they participate in agonist-induced renal vasoconstriction or vasodilation.",
"KV 7 channel subtypes in renal arterioles were characterized by immunofluorescence. Renal blood flow (RBF) was measured ... | It is concluded that K(V)7 channels, via nifedipine sensitive channels, have a role in the regulation of basal renal vascular tone. There is no indication that K(V)7 channels have an effect on agonist-induced renal vasoconstriction while there is a small effect on acetylcholine-induced vasodilation. | yes |
25,964,507 | Does abnormal Myocardial Function be Related to Myocardial Steatosis and Diffuse Myocardial Fibrosis in HIV-Infected Adults? | {
"contexts": [
"Impaired cardiac function persists in the era of effective human immunodeficiency virus (HIV) therapy, although the etiology is unclear. We used magnetic resonance imaging (MRI) to measure intramyocardial lipid levels and fibrosis as possible contributors to HIV-associated myocardial dysfunction.... | HIV-infected adults have reduced myocardial function as compared to controls in the absence of known CVD. Decreased cardiac function was associated with abnormal myocardial tissue composition characterized by increased lipid levels and diffuse myocardial fibrosis. Metabolic alterations related to antiretroviral therapy... | yes |
25,979,617 | Is severe intrahepatic cholestasis of pregnancy a risk factor for preeclampsia in singleton and twin pregnancies? | {
"contexts": [
"Intrahepatic cholestasis of pregnancy (ICP) is known to be associated with fetal complications. It recently was suggested to be associated possibly with preeclampsia (PET) as well. The objective of this study was to investigate that possibility.",
"The study group included 78 women (54 single... | ICP increases the incidence of PET; severe disease was a major risk factor for preeclampsia. Therefore, we strongly suggest including routine evaluation for preeclampsia in the treatment of women with moderate and severe ICP. | yes |
25,969,722 | Is high-normal urinary albumin-to-creatinine ratio independently associated with metabolic syndrome in Chinese patients with type 2 diabetes mellitus : A cross-sectional community-based study? | {
"contexts": [
"Microalbuminuria is positively related to metabolic syndrome (MetS). Our aim was to investigate whether urinary albumin-to-creatinine ratio (UACR) within the normal range is independently associated with MetS in Chinese community-based patients with type 2 diabetes.",
"A total of 514 particip... | These results suggest that UACR even within the normal range is independently associated with MetS in Chinese community-based patients with type 2 diabetes mellitus. | yes |
25,968,094 | Does total atrial conduction time evaluated with tissue Doppler imaging increase in hypertensive patients with hyperuricemia? | {
"contexts": [
"Serum uric acid (SUA) is an independent predictor of cardiovascular events in patients with hypertension. Total atrial conduction time (TACT) is a novel echocardiographic parameter used to identify the presence of electrical and structural atrial remodeling. We hypothesized that elevated SUA leve... | TACT increases in patients with hyperuricemia. Certainly, larger studies in different populations should further examine this potential association. | yes |
25,971,309 | Does nOB1 expression predict early response to cisplatin-based chemotherapy in patients with advanced non-small cell lung cancer? | {
"contexts": [
"The aim of this study was to investigate the predictive value of Nin one binding (NOB1) expression for response to cisplatin-based chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC).",
"A total of 105 consecutive patients with advanced NSCLC were retrospectively investi... | Our results suggest that enhanced expression of NOB1 related with poor early response to cisplatin-based chemotherapy in patients with advanced non-small cell lung cancer. | yes |
25,976,655 | Does estrogen promote the survival of human secretory phase endometrial stromal cells via CXCL12/CXCR4 up-regulation-mediated autophagy inhibition? | {
"contexts": [
"What mechanism is involved in regulating the autophagy of endometrial stromal cells (ESCs), and does it participate in the pathogenesis of endometriosis?"
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Adult",
"Autophagy",
"Chemokine CXCL12",
"Endometriosis",
"Endometr... | CXCL12 down-regulates secretory phase ESC autophagy. | yes |
25,965,620 | Is hemodynamic , not ventilatory , inefficiency associated with high VE/VCO2 slope in repaired , noncyanotic congenital heart disease? | {
"contexts": [
"A high slope of the ventilation vs. carbon dioxide relationship (VE/VCO₂ slope) during incremental exercise has been reported in several congenital heart disease (CHD) types, but it is not clear whether the main cause of high VE/VCO₂ slope is excessive ventilation or reduced perfusion.",
"We ... | A high VE/VCO₂ slope observed in patients with repaired, noncyanotic CHD seems not to depend on excessive ventilation but on hypoperfusion due to impaired cardiac output response to incremental exercise. This finding should focus researchers' attention mainly on the heart when addressing exercise pathophysiology of thi... | yes |
25,973,401 | Does dental caries and their treatment need in 3-5 year old preschool children in a rural district of India? | {
"contexts": [
"Dental problems in the preschool children are neglected by their parents as the deciduous teeth are going to shed off, and hence considered to be of no importance and more of economic burden if attended to them.",
"This study was to determine the caries prevalence in preschool children (3-5-y... | The most common pattern was pit and fissure, then maxillary anterior pattern, posterior proximal pattern, and posterior buccal lingual smooth surface pattern. The mean deft value was higher in males as compared to females. There is a greater need for oral health education among parents and teachers. | yes |
25,977,408 | Does nicotine Metabolite Ratio be Associated With Lozenge Use But Not Quitting in Smokeless Tobacco Users? | {
"contexts": [
"The nicotine metabolite ratio (NMR) of 3'-hydroxycotinine to cotinine is a noninvasive marker of the rate of nicotine metabolism. Fast metabolism (ie, a high NMR) is associated with lower cigarette smoking abstinence rates using transdermal nicotine replacement. We evaluated whether the NMR can b... | Fast metabolizers may need to self-administer more nicotine replacement in the form of nicotine lozenges to achieve the same clinical response achieved by slower metabolizers using fewer lozenges. | yes |
25,982,798 | Does low anthropometric measures and mortality -- result from the Malmö Diet and Cancer Study? | {
"contexts": [
"To study the association between anthropometric measures: body mass index (BMI), percent body fat, waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), waist-to-hip-to-height ratio (WHHR), and A Body Shape Index (ABSI); to see if individuals in the lowest 5 percentile... | These results imply that BMI or percent body fat could be used to identify lean individuals at increased mortality risk. | yes |
25,973,050 | Does holoturia arenicola extract modulate bile duct ligation-induced oxidative stress in rat kidney? | {
"contexts": [
"Acute Renal Failure (ARF) in patients with cirrhosis is one of the most frequently encountered complications of obstructive jaundice. Marine organisms from the Mediterranean Coast of Egypt are considered potential sources of bioactive molecules. The present study was undertaken to explore the cur... | The present study revealed that HaE had a profound effect against BDL-induced oxidative stress in the kidney tissues which is the common feature of choestasis in the liver. | yes |
25,964,205 | Does regenerative Therapy prevent Heart Failure Progression in Dyssynchronous Nonischemic Narrow QRS Cardiomyopathy? | {
"contexts": [
"Cardiac resynchronization therapy using bi-ventricular pacing is proven effective in the management of heart failure (HF) with a wide QRS-complex. In the absence of QRS prolongation, however, device-based resynchronization is reported unsuitable. As an alternative, the present study tests a regen... | In narrow QRS HF, a regenerative approach demonstrated functional and structural benefit, introducing the prospect of device-autonomous resynchronization therapy for refractory disease. | yes |
25,981,570 | Does prolonged intra-aortic balloon pump support in biventricular heart failure induce right ventricular reverse remodeling? | {
"contexts": [
"Right ventricular dysfunction is associated with high morbidity and mortality in candidates for left ventricular assist device (LVAD) implantation or cardiac transplantation.",
"We examined the effects of prolonged intra-aortic balloon pump (IABP) support on right ventricular, renal and hepat... | Prolonged IABP support of patients presenting with end-stage heart failure and right ventricular dysfunction induced significant improvement in right ventricular and peripheral organ function. | yes |
25,982,837 | Does in situ coating make it easier for children to swallow and tolerate tablets and capsules? | {
"contexts": [
"Getting children to swallow tablets and capsules is a challenge, and factors that influence their ability to swallow include taste, smell and texture. The aim of this study was to explore how well paediatric patients tolerated and accepted the MedCoat(®) in situ coating for tablets and capsules."... | A study of 77 paediatric patients with a median age of nine years, and a range of two to 17 years, found that 86% were able to take the tablets and capsules they had been prescribed after they were coated with the MedCoat. | yes |
25,968,967 | Does remote ischemic preconditioning increase circulating or effector organ concentrations of proopiomelanocortin derivates? | {
"contexts": [
"The aim of the present study was to compare changes in circulating levels of proopiomelanocortin (POMC) derivates and lactate after remote ischemic preconditioning (IPC) and physical exercise.",
"Remote IPC (rIPC) is cardioprotective following acute myocardial infarction and major cardiac sur... | We were not able to demonstrate a detectable increase in circulating POMC derivates by a standard rIPC stimulus, suggesting that rIPC effect is not mediated by local or detectable central release of these derivates. | no |
25,968,969 | Is age-related decline in mitral peak diastolic velocities unaffected in well-trained runners? | {
"contexts": [
"We examined whether diastolic left ventricular function in young and senior lifelong endurance runners was significantly different from that in sedentary age-matched controls, and whether lifelong endurance running appears to modify the age-related decline in diastolic left ventricular function."... | Lifelong endurance running was not found to be associated with major attenuation of the age-related decline in diastolic function at rest or during exercise. | yes |
25,976,932 | Does small heterodimer partner attenuate profibrogenic features of hepatitis C virus-infected cells? | {
"contexts": [
"An atypical orphan nuclear receptor small heterodimer partner (SHP) is known to be regulated by AMP-activated protein kinase (AMPK). Both of them inhibit TGF-β and Smad signalling and exhibit antifibrotic activity in the liver. However, little is known about the protective effects of SHP and AMPK... | These results demonstrate that overexpression of SHP and activation of AMPK reverses profibrogenic features of HCV-infected cells by decreasing TGF-β and fibrotic gene expression. These findings provide a rationale for SHP as a possible therapeutic target against HCV-induced hepatic fibrosis. | yes |
25,962,648 | Does lung function impairment increase with age of diagnosis in adult onset asthma? | {
"contexts": [
"Asthma-onset in older individuals has been associated with an accelerated decline in lung function, but direct comparisons with younger adults have not been reported.",
"In a random population sample comprising 4983 individuals from the Copenhagen City Heart Study without asthma at baseline, ... | Asthma was diagnosed as frequently in older as in younger adults. Preexisting symptoms were equally common, but lung function was more reduced pre-diagnosis, and declined more rapidly in older adults. This emphasizes the need for a high level of therapeutic attention in patients with asthma diagnosed late in life. | yes |
25,958,766 | Does higher positive lymph node ratio indicate poorer distant metastasis-free survival in adenoid cystic carcinoma patients with nodal involvement? | {
"contexts": [
"Extensive studies have been conducted to analyze adenoid cystic carcinoma (ACC) in the head and neck region. No research has been published focusing on ACC patients with cervical lymph node (LN) metastasis. The aims of current investigation were to summarize the clinical characteristics of ACC pa... | Positive LN ratio was strongly associated with distant metastasis. Comprehensive treatment should be performed in ACC patients with higher positive LN ratios. In addition, ideal surgical margin should be achieved to acquire better overall survival rate. | yes |
25,984,891 | Does overspeed HIIT in Lower-Body Positive Pressure Treadmill improve Running Performance? | {
"contexts": [
"Optimal high-intensity interval training (HIIT) regimens for running performance are unknown, although most protocols result in some benefit to key performance factors (running economy (RE), anaerobic threshold (AT), or maximal oxygen uptake (VO2max)). Lower-body positive pressure (LBPP) treadmil... | A 4-wk HIIT protocol at 100% vVO2max improves field performance, vVO2max, VO2max and submaximal HR in trained runners. Improvements are similar if intervals are run on a regular treadmill or at higher speeds on a LPBB treadmill with 10% body weight reduction. LBPP could provide an alternative for taxing HIIT sessions. | yes |
25,981,892 | Is family history of autoimmune diseases associated with an increased risk of autism in children : A systematic review and meta-analysis? | {
"contexts": [
"We conducted a systematic review and meta-analysis to summarize the current evidence on the relationship between family history of autoimmune diseases (ADs) and risk of autism in children, as current evidence suggests inconsistent results.",
"We identified relevant studies by searching PubMed... | An overall increased risk of autism in children with family history of ADs was identified. More mechanistic studies are needed to further explain the association between family history of ADs and increased risk of autism in children. | yes |
25,976,223 | Do cYP3A4∗18B and CYP3A5∗3 polymorphisms contribute to pharmacokinetic variability of cyclosporine among healthy Chinese subjects? | {
"contexts": [
"Cyclosporine is an immunosuppressant drug used to prevent allograft rejection. It is metabolized by CYP3A4 and CYP3A5, has a narrow therapeutic index, and variable pharmacokinetics. Here, we investigated whether CYP3A5∗3 and CYP3A4∗18B polymorphisms contribute to inter-individual pharmacokinetic ... | The results indicate that gender and polymorphism in CYP3A4∗18B and CYP3A5∗3 significantly affect cyclosporine pharmacokinetics in healthy subjects. | yes |
25,986,435 | Do human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat? | {
"contexts": [
"Mesenchymal stromal cells (MSCs) demonstrate considerable promise in preclinical acute respiratory distress syndrome models. We wished to determine the efficacy and mechanisms of action of human MSCs (hMSCs) in the setting of acute lung injury induced by prolonged Escherichia coli pneumonia in th... | hMSC therapy decreased E. coli induced pneumonia injury and reduced lung bacterial burden, potentially via enhanced macrophage phagocytosis and increased alveolar LL-37 concentrations. | yes |
25,973,343 | Do pharmacologically relevant doses of valproate upregulate CD20 expression in three diffuse large B-cell lymphoma patients in vivo? | {
"contexts": [
"Epigenetic code modifications by histone deacetylase inhibitors (HDACi) have been proposed as potential new therapies for lymphoid malignancies. Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive lymphoma for which standard first line treatment is the chemotherapy regimen... | Valproate treatment at pharmacologically relevant doses resulted in upregulation of CD20 in vivo, and also in expected epigenetic modifications. This suggests that pre-treatment with valproate or other HDACis before anti-CD20 therapy could be advantageous in CD20-low B-cell lymphomas. Further studies are warranted to e... | yes |
25,986,046 | Does a seven-gene CpG-island methylation panel predict breast cancer progression? | {
"contexts": [
"DNA methylation regulates gene expression, through the inhibition/activation of gene transcription of methylated/unmethylated genes. Hence, DNA methylation profiling can capture pivotal features of gene expression in cancer tissues from patients at the time of diagnosis. In this work, we analyzed... | Our findings identify CpG-island methylation profiles with deep impact on clinical outcome, paving the way for use as novel prognostic assays in clinical settings. | yes |
25,969,437 | Is low P-wave amplitude ( < 0.1 mV ) in lead I associated with displaced inter-atrial conduction and clinical recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation? | {
"contexts": [
"We hypothesized that P-wave amplitude in lead I is related to left atrial (LA) remodelling and inter-atrial conduction pattern, and has a predictive value for recurrence after radiofrequency catheter ablation (RFCA) among patients with paroxysmal atrial fibrillation (PAF).",
"A total of 525 c... | Low P-wave amplitude (<0.1 mV) in lead I is related to LA remodelling and displaced inter-atrial conduction pattern to low septum, and independently predicts clinical recurrence after RFCA in patients with PAF. | yes |
25,969,431 | Does prophylactic treatment with S100A9 inhibitor paquinimod reduce pathology in experimental collagenase-induced osteoarthritis? | {
"contexts": [
"Alarmins S100A8/A9 regulate pathology in experimental osteoarthritis (OA). Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. We investigated the effect of paquinimod on experimental OA and human OA synovium.",
"Two OA mouse models differing in level of synovial ac... | Prophylactic treatment of paquinimod reduces synovial activation, osteophyte formation and cartilage damage in experimental OA with high synovial activation (CIOA) and ameliorates pathological effects of S100A9 in OA synovium ex vivo. | yes |
25,962,593 | Are aTP-binding cassette subfamily B member 1 ( ABCB1 ) and subfamily C member 10 ( ABCC10 ) primary resistance factors for cabazitaxel? | {
"contexts": [
"ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells. Cabazitaxel is a novel taxane that differs fro... | ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel, suggesting that cabazitaxel may have a low affinity for these efflux transporters. | no |
25,964,397 | Is more Comprehensive Care Among Family Physicians Associated with Lower Costs and Fewer Hospitalizations? | {
"contexts": [
"Comprehensiveness is lauded as 1 of the 5 core virtues of primary care, but its relationship with outcomes is unclear. We measured associations between variations in comprehensiveness of practice among family physicians and healthcare utilization and costs for their Medicare beneficiaries.",
... | Increasing family physician comprehensiveness of care, especially as measured by claims measures, is associated with decreasing Medicare costs and hospitalizations. Payment and practice policies that enhance primary care comprehensiveness may help "bend the cost curve." | yes |
25,972,815 | Does proteomic analysis of media from lung cancer cells reveal role of 14-3-3 proteins in cachexia? | {
"contexts": [
"At the time of diagnosis, 60% of lung cancer patients present with cachexia, a severe wasting syndrome that increases morbidity and mortality. Tumors secrete multiple factors that contribute to cachectic muscle wasting, and not all of these factors have been identified. We used Orbitrap electrosp... | Our novel findings show that extracellular 14-3-3 proteins may act as previously unidentified myokines and may signal via CD13 to help maintain muscle mass. | yes |
25,986,250 | Do expression of Aurora-B and FOXM1 predict poor survival in patients with nasopharyngeal carcinoma? | {
"contexts": [
"The purpose of this work was to investigate the relationship between Aurora-B, FOXM1, and clinical outcomes in patients with nasopharyngeal carcinoma (NPC) who were treated with a combination of induction chemotherapy and radiotherapy.",
"The expression of Aurora-B and FOXM1 were investigated... | Aurora-B and FOXM1 were both adverse prognostic markers for NPC patients treated with chemoradiotherapy. However, the two markers had no significant correlation. | yes |
25,987,395 | Is mean platelet volume a predictor of ST resolution following thrombolysis in acute ST elevation myocardial infarction? | {
"contexts": [
"Larger mean platelets volumes (MPV) are thrombogenic and frequently seen after ST-segment elevation myocardial infarction (STEMI). This study aimed to examine the association of MPV and resolution of ST-segment after thrombolysis in STEMI patients as and its impact on clinical outcome.",
"Pat... | Higher MPV's at admission were associated with lower STR and higher occurrence of major adverse cardiac events in patients receiving thrombolytic therapy for first time STEMI. | yes |
25,958,219 | Is hair cortisone level associated with PTSD׳s dysphoric arousal symptoms in highly traumatized Chinese females? | {
"contexts": [
"Cortisone has been proposed as a useful additional biomarker for stress research. However, only very limited studies has investigated alterations of cortisone levels in stress-related mental disorder such as PTSD. The present study investigated the associations between PTSD symptomatology and hai... | A sample of females exposed to specific traumatic events was used, and PTSD was assessed using a self-reported measure. | yes |
25,974,743 | Do angiotensin receptor blockers improve survival outcomes after radiofrequency ablation in hepatocarcinoma patients? | {
"contexts": [
"Inhibition of angiotensin II synthesis seems to decrease hepatocellular carcinoma recurrence after radical therapies; however, data on the adjuvant role of angiotensin II receptor 1 blockers (sartans) are still lacking. The aim of the study was to evaluate whether sartans delay time to recurrence... | Sartans significantly improved overall survival and time to recurrence after radiofrequency ablation in hepatocellular carcinoma patients. | yes |
25,977,398 | Does genome sequencing reveal novel deletions associated with secondary resistance to pyrazinamide in MDR Mycobacterium tuberculosis? | {
"contexts": [
"Detection of pyrazinamide resistance in Mycobacterium tuberculosis isolates presents significant challenges in settings with no dominant clonal lineages, such as Australia. We assessed the utility of WGS versus standard PCR amplification assays for the characterization of pyrazinamide resistance ... | Steadily decreasing sequencing costs are increasing the appeal of WGS as an alternative approach for detecting complex patterns of pyrazinamide resistance in MDR-TB. | yes |
25,988,219 | Does dNA entropy reveal a significant difference in complexity between housekeeping and tissue specific gene promoters? | {
"contexts": [
"The complexity of DNA can be quantified using estimates of entropy. Variation in DNA complexity is expected between the promoters of genes with different transcriptional mechanisms; namely housekeeping (HK) and tissue specific (TS). The former are transcribed constitutively to maintain general ce... | Functional features comprise DNA sequence patterns that are non-random and hence they have lower entropies. The lower entropy of TS gene promoters can be explained by a higher density of positive and negative regulatory elements, required for genes with complex spatial and temporary expression. | yes |
25,988,216 | Is neoadjuvant chemoradiation for rectal cancer associated with higher rates of thromboembolism? | {
"contexts": [
"Thromboembolism (TE) is a leading cause of death amongst cancer patients. The effect of neoadjuvant chemoradiotherapy (nCRT) on the risk of TE in rectal cancer patients is unknown. The aim of this study was to determine whether nCRT was associated with an increased risk of TE in patients with rec... | The prevalence of TE in patients with rectal cancer was 7.8%, with most events occurring in within 30 days of surgery. Neoadjuvant chemoradiation was not associated with an increased risk of TE. | no |
25,973,665 | Does tPEN prevent rapid pacing-induced calcium overload and nitration stress in HL-1 myocytes? | {
"contexts": [
"Atrial fibrillation (AF) is the most common cardiac arrhythmia. However, the current drug interference of antiarrhythmia has limited efficacy and off-target effects. Accumulating evidence has implicated a potential role of nitration stress in the pathogenesis of AF. The aim of the study was to de... | TPEN prevents Ca(2+) overload and nitration stress in HL-1 atrial myocytes during rapid pacing and circumstances of nitration stress. | yes |
25,965,821 | Is merTK a novel therapeutic target in gastric cancer? | {
"contexts": [
"The role of MerTK has not been assessed in gastric cancer (GC). The aim of this study was to identify a subgroup of GC patients with MerTK tumor overexpression, and to evaluate MerTK as a potential therapeutic target in this disease.",
"Protein and mRNA expression of MerTK were evaluated, and... | MerTK may be involved in GC carcinogenesis, and it could be a potential novel therapeutic target in GC patients. | yes |
25,987,839 | Is low-density lipoprotein cholesterol of less than 70 mg/dL associated with fewer cardiovascular events in acute coronary syndrome patients : a real-life cohort in Thailand? | {
"contexts": [
"Elevated low-density lipoprotein cholesterol (LDL-C) is associated with an increased risk of cardiovascular disease or mortality; however, the LDL-C goal for therapy in acute coronary syndrome (ACS) patients is controversial and varies among guidelines. This study aimed to assess the effect of re... | ACS patients who received statins and achieved an LDL-C of <70 mg/dL had significantly fewer composite cardiovascular outcomes, confirming "the lower the better" and the benefit of treating to LDL-C target in ACS patient management. | yes |
25,969,668 | Does miR-124 suppress cell motility and adhesion by targeting talin 1 in prostate cancer cells? | {
"contexts": [
"MicroRNA is a type of endogenous non-coding RNA implicated in various cellular processes, and has been intensely investigated in the field of cancer research for many years. Here, we investigated the functions and mechanisms of miR-124 in prostate cancer, which is a putative tumor suppressor repo... | Our study demonstrated biological roles and the related mechanism of miR-124 in prostate cancer. The results indicate that talin 1 is very likely a novel player in the anti-metastatic signaling network of miR-124. By down-regulation of talin 1, miR-124 impairs the adhesion, migration, and invasion of prostate cancer ce... | yes |
25,966,900 | Is cognitive impairment a predictor of failure to adhere to anticoagulation of stroke patients with atrial fibrillation? | {
"contexts": [
"Oral anticoagulation (OAC) with vitamin K antagonists (VKA) or direct oral anticoagulants (DOAC) is an effective strategy that is used for stroke prevention in patients with atrial fibrillation (AF). However, OAC is underused particularly in elderly patients, who are often physically disabled or ... | In stroke and TIA patients with AF, the multifactorial medical and functional constellation rather than cognitive impairment specifically can be an obstacle for long-term OAC. | no |
25,975,200 | Does roux-en-Y Gastric Bypass Acutely decrease Protein Carbonylation and Increases Expression of Mitochondrial Biogenesis Genes in Subcutaneous Adipose Tissue? | {
"contexts": [
"Mitochondrial dysfunction in adipose tissue has been implicated as a pathogenic step in the development of type 2 diabetes mellitus (T2DM). In adipose tissue, chronic nutrient overload results in mitochondria driven increased reactive oxygen species (ROS) leading to carbonylation of proteins that... | These results suggest that rapid reduction in protein carbonylation and increased mitochondrial biogenesis may explain postoperative metabolic improvements following RYGB. | yes |
25,980,380 | Is waist-to-height ratio more closely associated with alanine aminotransferase levels than body mass index and waist circumference among population-based children : a cross-sectional study in Japan? | {
"contexts": [
"An association between anthropometric measurements, including waist circumference (WC), and alanine aminotransferase (ALT) levels has been reported among adults. However, studies conducted among population-based elementary schoolchildren to date have been limited, especially in Japan, where the m... | The present study showed that WHtR was more closely associated with ALT levels than BMI and WC. Furthermore, only WHtR was significantly positively associated with ALT levels regardless of sex and physique. This study suggests that it is more useful to monitor WHtR than BMI and WC as a surrogate for ALT levels among po... | yes |
25,972,347 | Are changes in HRQoL after 12 months of exercise linked to primary care associated with fitness effects in older adults? | {
"contexts": [
"To analyse the effects of 1 year of participation in a physical activity (PA) program linked to a health-care setting on physical fitness (PF) and health-related quality of life (HRQoL) and to determine the relationships between PA, PF and HRQoL in middle-aged and older adults.",
"In total, 3... | PF is positively related with HRQoL. PA significantly improved PF, especially the PF components more impaired at baseline. | yes |
25,962,852 | Is preeclampsia Characterized by Fetal NK Cell Activation and a Reduction in Regulatory T Cells? | {
"contexts": [
"Preeclampsia affects 3-17% of pregnancies worldwide and has serious consequences for both the mother and the fetus. As maternal-fetal immune tolerance is bidirectional, fetal immunopathology may play a significant role in the pathogenesis of pregnancy disorders. Nevertheless, the impact of preecl... | These observations indicate that there are significant fetal immune system derangements during preeclampsia. | yes |
25,962,080 | Does β1-Adrenergic Inhibition improve Cardiac and Vascular Function in Experimental Septic Shock? | {
"contexts": [
"Preliminary experimental data suggest that selective β1-blockers may improve ex vivo cardiac function in animal sepsis. Currently, the effects of esmolol on in vivo cardiac function and on vascular function are unknown. The present study was designed to examine the effects of the β1-selective blo... | Adjunction of selective β1-blockade to standard septic shock management enhances intrinsic cardiac contractility and vascular responsiveness to catecholamines. These protective cardiovascular effects are likely predominantly attributed to the anti-inflammatory effect of esmolol. | yes |
25,960,780 | Does streptozotocin-induced diabetes disrupt the body temperature daily rhythm in rats? | {
"contexts": [
"In mammals, the temperature rhythm is regulated by the circadian pacemaker located in the suprachiasmatic nuclei, and is considered a \"marker rhythm\". Melatonin, the pineal gland hormone, is a major regulator of the endogenous rhythms including body temperature. Its production is influenced by ... | Taken together, our findings show the disruption of the body temperature daily rhythm, a new consequence of insulin-dependent diabetes, as well as the beneficial effect of the complementary action of melatonin and insulin restoring the normal rhythmicity. | yes |
25,964,429 | Is serum human trefoil factor 3 a biomarker for mucosal healing in ulcerative colitis patients with minimal disease activity? | {
"contexts": [
"The goals of treating ulcerative colitis (UC) have shifted from clinical remission to mucosal healing. Non-invasive biomarkers are required to assess mucosal healing as endoscopic assessment is inconvenient for patients. Enhanced expression of trefoil factor 3 (TFF3, a mucin-associated peptide) i... | Serum TFF3 can potentially be used as a biomarker to assess mucosal healing in UC patients. | yes |
25,960,429 | Does mitochondria-targeted hydrogen sulfide donor AP39 improve neurological outcomes after cardiac arrest in mice? | {
"contexts": [
"Mitochondria-targeted hydrogen sulfide donor AP39, [(10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl)phenoxy)decyl) triphenylphosphonium bromide], exhibits cytoprotective effects against oxidative stress in vitro. We examined whether or not AP39 improves the neurological function and long term survival... | The current results suggest that administration of mitochondria-targeted sulfide donor AP39 at the time of CPR or after ROSC improves the neurological function and long term survival rates after CA/CPR by maintaining mitochondrial integrity and reducing oxidative stress. | yes |
25,974,331 | Is thyroid function associated with non-alcoholic fatty liver disease in chronic hepatitis B-infected subjects? | {
"contexts": [
"Associations between thyroid function and non-alcoholic fatty liver disease (NAFLD) are unknown in chronic hepatitis B (CHB)-infected patients. Thus, the aim of the study was to investigate the prevalence of thyroid dysfunction and its relationship with NAFLD in CHB.",
"Consecutive naive CHB ... | Thyroid dysfunction is not common in CHB-infected patients, and the prevalence of hypothyroidism in CHB individuals with or without NAFLD is similar. However, increased serum TSH concentration at the normal range is a significant predictor of hepatic steatosis in patients with CHB. | yes |
25,964,079 | Does long noncoding RNA DANCR increase stemness features of hepatocellular carcinoma by derepression of CTNNB1? | {
"contexts": [
"Tumor cells with stemness (stem-cell) features contribute to initiation and progression of hepatocellular carcinoma (HCC), but involvement of long noncoding RNAs (lncRNAs) remains largely unclear. Genome-wide analyses were applied to identify tumor-associated lncRNA-DANCR. DANCR expression level ... | These studies reveal a significance and mechanism of DANCR action in increasing stemness features and offer a potential prognostic marker and a therapeutic target for HCC. | yes |
25,980,948 | Are coronary calcium scores systematically underestimated at a large chest size : A multivendor phantom study? | {
"contexts": [
"To evaluate the effect of chest size on coronary calcium score (CCS) as assessed with new-generation CT systems from 4 major vendors.",
"An anthropomorphic, small-sized (300 × 200 mm) chest phantom containing 100 small calcifications (diameters, 0.5-2.0 mm) was evaluated with and without an e... | This multivendor phantom study showed that CCS can be underestimated up to 50% (49%-66%) for Agatston scores and 49% (36%-59%) for mass scores at a larger chest size, which may be relevant for women and large patients. However, CCS underestimation by chest size differs considerably by vendor. | yes |
25,981,919 | Is sensitivity of apoptosis-resistant colon cancer cells to tanshinones mediated by autophagic cell death and p53-independent cytotoxicity? | {
"contexts": [
"Multidrug resistance (MDR) develops in nearly all patients with colon cancer. The reversal of MDR plays an important role in the success of colon cancer chemotherapy. One of the commonest mechanisms conferring MDR is the suppression of apoptosis in cancer cells.",
"This study investigated the... | The current findings strongly indicate that both CTS and DTS could inhibit the growth of apoptosis-resistant colon cancer cells through induction of autophagic cell death and p53-independent cytotoxicity. They are promising candidates to be further developed as therapeutic agents in the adjuvant therapy for colon cance... | yes |
25,970,502 | Is metabolic profile in early pregnancy associated with offspring adiposity at 4 years of age : the Rhea pregnancy cohort Crete , Greece? | {
"contexts": [
"Maternal pre-pregnancy obesity may increase the risk of childhood obesity but it is unknown whether other metabolic factors in early pregnancy such as lipid profile and hypertension are associated with offspring cardiometabolic traits.",
"Our objective was to investigate whether fasting lipid... | Metabolic dysregulation in early pregnancy may increase the risk of obesity at preschool age. | yes |
25,981,893 | Is type 1 diabetes associated with an increased prevalence of hepatic steatosis? | {
"contexts": [
"Non-alcoholic fatty liver disease (NAFLD) is commonly associated with Type 2 diabetes. Recently, it has been suggested that NAFLD is also frequently associated with Type 1 diabetes and diabetic complications. In this study, we set out to determine whether Type 1 diabetes was associated with liver... | Our data showed that Type 1 diabetes was not associated with an increased prevalence of steatosis. Moreover, our study provided no specific arguments concerning a link between liver fat content and diabetic complications in patients with Type 1 diabetes. | no |
25,963,324 | Does brain-Derived Neurotrophic Factor contribute to Colonic Hypermotility in a Chronic Stress Rat Model? | {
"contexts": [
"Brain-derived neurotrophic factor (BDNF) has prokinetic effects on gut motility and is increased in the colonic mucosa of irritable bowel syndrome.",
"We aimed to investigate the possible involvement of BDNF in stress-induced colonic hypermotility.",
"Male Wistar rats were exposed to dail... | The colonic hypermotility induced by repeated WAS may be associated with the increased expression of endogenous BDNF and TrkB. BDNF may have potential clinical therapeutic use in modulating gut motility. | yes |
25,963,323 | Does vitamin-D Deficiency be Associated with Gallbladder Stasis Among Pregnant Women? | {
"contexts": [
"Pregnant women are at increased risk of gallbladder (GB) stasis, an important risk factor for gallstones (GS). In non-pregnant women, Vitamin-D deficiency (VDD) is associated with GB stasis, which improves on supplementation. Relationship of VDD with GB stasis among pregnant women is not known.",... | Vitamin D deficiency is highly prevalent among pregnant Indian women. It is associated with GB stasis and lower GBEF. The risk factors for VDD were reduced sun exposure, inadequate dietary intake and urban lifestyle. | yes |
25,961,013 | Does relationship between Hyperuricemia and Haar-Like feature on Tongue Images? | {
"contexts": [
"To investigate differences in tongue images of subjects with and without hyperuricemia.",
"This population-based case-control study was performed in 2012-2013. We collected data from 46 case subjects with hyperuricemia and 46 control subjects, including results of biochemical examinations and... | Symmetrical Haar-like features enabled discrimination of subjects with and without hyperuricemia in our sample. The locations of these discriminative features were in agreement with the interpretation of tongue appearance in traditional Chinese and Western medicine. | yes |
25,967,536 | Do different genetic factors underlie fear conditioning and episodic memory? | {
"contexts": [
"Fear conditioning seems to account for the acquisition of post-traumatic stress disorder, whereas conscious recall of events in aftermath of trauma reflects episodic memory. Studies show that both fear conditioning and episodic memory are heritable, but no study has evaluated whether they reflect... | Individual differences in fear conditioning and episodic memory reflect distinct genetically influenced processes, suggesting that the genetic risk for learning-induced anxiety disorders includes at least two memory-related genetic factors. These findings are consistent with the facts that the two separate learning for... | yes |
25,982,824 | Does short-Term Caloric Restriction suppress Cardiac Oxidative Stress and Hypertrophy Caused by Chronic Pressure Overload? | {
"contexts": [
"Caloric restriction (CR) prevents senescent changes, in which reactive oxygen species (ROS) have a critical role. Left ventricular (LV) hypertrophy is a risk factor for cardiovascular diseases. We examined whether CR alters cardiac redox state and hypertrophy from chronic pressure overload.",
... | Chronic pressure overload increased cardiac oxidative damage, in association with cardiac hypertrophy and fibrosis. Short-term CR suppressed oxidative stress and improved cardiac function, suggesting that short-term CR could be a useful strategy to prevent pressure overload-induced cardiac injury. | yes |
25,982,826 | Does nurse-Enhanced Computerized Cognitive Training Increases Serum Brain-Derived Neurotropic Factor Levels and improve Working Memory in Heart Failure? | {
"contexts": [
"Memory loss is common in heart failure (HF) patients, but few interventions have been tested to treat it. The objective of this study was to evaluate efficacy of a cognitive training intervention, Brain Fitness, to improve memory, serum brain-derived neurotropic factor (BDNF) levels, working memo... | Findings support efficacy of Brain Fitness in improving working memory and serum BDNF levels as a biomarker of intervention response. A randomized controlled study is needed among a larger more diverse group of HF patients. | yes |
25,968,975 | Does 14,15-epoxyeicosatrienoic Acid suppress cigarette smoke extract-induced apoptosis in lung epithelial cells by inhibiting endoplasmic reticulum stress? | {
"contexts": [
"Epoxyeicosatrienoic acids (EETs), a type of lipid mediators produced by cytochrome P450 epoxygenases, exert anti-inflammatory, angiogenic, anti-oxidative and anti-apoptotic effects. However, the role of EETs in cigarette smoke-induced lung injury and the underlying mechanisms are not fully known.... | The data suggest that CYP2J2-derived EETs protect against CSE-induced lung injury possibly through attenuating ER stress. | yes |
25,971,328 | Is diabetes mellitus associated with breast cancer : systematic review , meta-analysis , and in silico reproduction? | {
"contexts": [
"Breast cancer (BrCa) and diabetes mellitus (DM) are two major heath problems in women and the general population. This study explores the association between DM and breast cancer patients' survival outcomes, as well as the potential therapeutic merits of metformin.",
"To explore the associati... | Women with DM are at higher risk of BrCa-specific and all-cause mortality after initial breast cancer diagnosis. BrCa patients with DM could possibly benefit from metformin treatment via DICER mediation. | yes |
25,963,637 | Does laparoscopy decrease the laparotomy rate for hemodynamically stable patients with blunt hollow viscus and mesenteric injuries? | {
"contexts": [
"The aim of this study was to evaluate the effect of laparoscopy on patients with blunt hollow viscus and mesenteric injuries (BHVMIs).",
"Hemodynamically stable patients with BHVMIs were diagnosed using computed tomography and serial examinations. Patients admitted from July 1, 1999 to June 3... | Laparoscopy is feasible and safe for hemodynamically stable patients with BHVMIs. | yes |
25,983,551 | Is polymorphism in variable number of tandem repeats of dopamine d4 gene a genetic risk factor in attention deficit hyperactive egyptian children : pilot study? | {
"contexts": [
"The variable number of tandem repeats (VNTR) of the dopamine receptor D4 (DRD4) gene among humans may elucidate individual differences in susceptibility to neuropsychiatric diseases. Dopamine dysfunction may be involved with Attention Deficit Hyperactivity Disorder (ADHD) symptoms. In this study,... | Children with smaller number of repeat alleles (two to four repeats) of the DRD4 gene have higher possibility to develop ADHD in Egyptian children. | yes |
25,986,074 | Do cancer antigen-125 levels predict long-term mortality in chronic obstructive pulmonary disease? | {
"contexts": [
"Cancer antigen-125 (CA-125) might be a useful biomarker to predict long-term mortality in patients with recent exacerbation of chronic obstructive pulmonary disease (COPD).",
"A total of 87 consecutive patients with COPD were evaluated prospectively. Mean age of patients was 68 ± 10 years (55... | For the first time, we demonstrated that CA-125 helps the risk stratification of patients with COPD. | yes |
25,966,773 | Is the serum CXCL13 level associated with the Glasgow Prognostic Score in extranodal NK/T-cell lymphoma patients? | {
"contexts": [
"The Glasgow Prognostic Score (GPS) measures inflammation and proves its prognostic value in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTL) which is commonly combined with inflammatory lesion. Given inflammatory chemokines play an important role in tumor progression, we hypot... | Serum levels of CXCL13 were associated with the prognostic value of GPS. Grouping by the serum CXCL13 might predict survival outcomes in patients with ENKTL, suggesting that it is a potential therapeutic target. | yes |
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