pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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|---|---|---|---|---|
19,255,218 | Does spinal hemiepiphysiodesis decrease the size of vertebral growth plate hypertrophic zone and cells? | {
"contexts": [
"Hemiepiphysiodesis is a potential method to treat idiopathic juvenile scoliosis early. The purpose of the present study was to investigate a mechanism of curve creation in the pig thoracic model of spinal hemiepiphysiodesis by determining whether the structure of the vertebral growth plate varied... | Unilateral control of intervertebral joint motion decreased growth plate height, cell size, and disc height. | yes |
19,259,843 | Does organizational culture influence health care workers ' influenza immunization behavior? | {
"contexts": [
"Low rates of influenza immunization among health care workers (HCWs) pose a potential health risk to patients in primary care practices. Despite previous educational efforts and programs to reduce financial barriers, HCW influenza immunization rates remain low. Variation in practice-level organiz... | In these practices, organizational culture was associated with varying rates of influenza immunization for HCWs, especially among nonphysicians. Addressing elements of organizational culture such as beliefs regarding influenza immunization and office policies may facilitate the immunization of all staff members. | yes |
19,255,294 | Is serum surfactant protein-A a strong predictor of early mortality in idiopathic pulmonary fibrosis? | {
"contexts": [
"Serum surfactant protein (SP) A and SP-D had prognostic value for mortality in patients with idiopathic pulmonary fibrosis (IPF) in prior studies before the reclassification of the idiopathic interstitial pneumonias. We hypothesized that baseline serum SP-A and SP-D concentrations would be indepe... | Increased serum SP-A level is a strong and independent predictor of early mortality among patients with IPF. A prediction model containing SP-A and SP-D was substantially superior to a model with clinical predictors alone. | yes |
19,276,859 | Does exercise training alter the molecular response to myocardial infarction? | {
"contexts": [
"We and others have shown that swimming exercise training performed before irreversible coronary occlusion improves the outcome of the heart injury and alters gene expression at the remodeling phase. The purpose of the current study was to identify temporal changes in the molecular response to myo... | Swimming exercise training conducted before acute MI reprograms the surviving myocardium for altered molecular response to MI that explains, in part, the protected cardiac phenotype of the exercised animals. | yes |
19,277,450 | Are cytokine responses of intraepithelial lymphocytes regulated by histamine H ( 2 ) receptor? | {
"contexts": [
"Histamine participates in the immune regulation of several gastrointestinal diseases. However, the effect of histamine on intestinal intraepithelial lymphocytes (IELs), the front line of the intestinal mucosal immune system, is not well understood. We examined whether histamine has a direct effec... | Histamine has a direct suppressive effect on IEL-derived cytokines via H(2)R, which would have a crucial role in the suppression of local immunoregulation in the intestinal epithelium. | yes |
19,262,754 | Does blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confer no protection to young children in Western Kenya? | {
"contexts": [
"The antigen, falciparum malaria protein 1 (FMP1), represents the 42-kDa C-terminal fragment of merozoite surface protein-1 (MSP-1) of the 3D7 clone of P. falciparum. Formulated with AS02 (a proprietary Adjuvant System), it constitutes the FMP1/AS02 candidate malaria vaccine. We evaluated this vac... | FMP1/AS02 is not a promising candidate for further development as a monovalent malaria vaccine. Future MSP-1(42) vaccine development should focus on other formulations and antigen constructs. | yes |
19,264,002 | Does [ Language of instruction and the effect on visual field result ]? | {
"contexts": [
"Automated perimetry, a psychophysical test, requires meticulous cooperation of the tested patient. Immigrant populations who do not speak the local language may have poorer performance. This study evaluates this effect.",
"The study was conducted in Israel where the dominant language is Hebre... | Proper instruction is critical for quality results in perimetry. The study indicated that immigrants would not be handicapped in their performance when given professional instruction in their own language. | yes |
19,246,914 | Does interaction between interleukin-8 and methylenetetrahydrofolate reductase genes modulate Alzheimer 's disease risk? | {
"contexts": [
"Interleukin-8 (IL-8), a potent chemoattractant for neutrophils, has been implicated in the pathogenesis of Alzheimer's disease (AD). The ability of individuals to produce high levels of IL-8 is partially determined by the IL-8 -251 T/A polymorphism. Therefore, we investigated the association betw... | Our data suggest a critical role for IL-8/MTHFR interactions in the development of AD. | yes |
19,246,916 | Is the long-term use of statins associated with a decreased incidence of adenomatous colon polyps? | {
"contexts": [
"Studies have suggested that statins may protect against colorectal cancer (CRC), but it is not clear whether that protection results from effects on established adenomatous polyps (APs) or from preventing the development of new APs. We have conducted a retrospective, cohort study to explore how t... | In patients with APs removed colonoscopically, long-term statin usage is associated with a decreased incidence of new and advanced APs. This suggests that statins may protect against CRC by reducing the development of new APs. | yes |
19,251,446 | Is the C609T variant of NQO1 associated with carotid artery plaques in patients with type 2 diabetes? | {
"contexts": [
"Atherosclerosis in patients with type 2 diabetes has been linked to oxidative stress. NADP[1]:quinone oxidoreductase 1 (NQO1) plays a key role in cellular antioxidant defense. Recent reports suggest that highly expressed and inducible endogenous NQO1 from cardiovascular cells may act as a potenti... | These results suggest that the C609T polymorphism of NQO1 is associated with carotid artery plaques in type 2 diabetic patients. | yes |
19,272,367 | Are mTAP and CDKN2B genes associated with myocardial infarction in Chinese Hans? | {
"contexts": [
"To investigate the association between cyclin-dependent kinase inhibitor 2A (CDKN2A) gene, cyclin-dependent kinase inhibitor 2B (CDKN2B) gene, and methylthioadenosine phosphorylase (MTAP) gene and myocardial infarction (MI) in Chinese Hans.",
"A total of 432 patients with MI and 430 controls ... | This study demonstrates for the first time that polymorphisms in CDKN2B and MTAP gene may influence the risk of MI in Chinese. | yes |
19,259,273 | Does a beta-catenin-dependent Wnt pathway mediate anteroposterior axon guidance in C. elegans motor neurons? | {
"contexts": [
"Wnts are secreted glycoproteins that regulate diverse aspects of development, including cell proliferation, cell fate specification and differentiation. More recently, Wnts have been shown to direct axon guidance in vertebrates, flies and worms. However, little is known about the intracellular si... | Together, our data provide evidence that Wnt-mediated axon guidance can be transduced through a beta-catenin-dependent pathway. | yes |
19,255,769 | Do falling FSH levels predict poor IVF pregnancy rates in patients whom the gonadotropins are withheld? | {
"contexts": [
"To determine whether monitoring follicle stimulating hormone (FSH) levels in over-responding patients whom the gonadotropins were withheld would predict pregnancy outcome.",
"A group of 33 female infertility patients aged between 20-40 years who had to be coasted during controlled ovarian hyp... | The results from this study show that monitoring serum FSH levels during coasting may be helpful in predicting the pregnancy outcome. | yes |
19,260,145 | Does daily mini quiz as means for improving student performance in anatomy course? | {
"contexts": [
"To evaluate daily-written 10-question quizzes in a medical anatomy course as a way to integrate assessment into the course and to evaluate their effect on the course success.",
"Students answering correctly 8/10 or more questions were awarded 0.5 points per quiz. There were 34 quizzes with a ... | Despite their frequency and possible associated stress, daily quizzes were associated with better academic success in the anatomy course. | yes |
19,260,140 | Is common variant in myocilin gene associated with high myopia in isolated population of Korcula Island , Croatia? | {
"contexts": [
"To study the association between genetic variants in myocilin and collagen type I alpha 1 genes and high myopia in an isolated island population.",
"A total of 944 examinees from the genetic epidemiology study conducted on the island of Korcula, Croatia, were included in the study. We selecte... | Myocilin seems to be a very strong candidate for explaining some of the pathophysiological pathways leading to the development of both glaucoma and high myopia. As our finding was obtained in a relatively under-powered sample, further research and replication of these results is needed. | yes |
19,261,175 | Do contributions of gut bacteria to Bacillus thuringiensis-induced mortality vary across a range of Lepidoptera? | {
"contexts": [
"Gut microbiota contribute to the health of their hosts, and alterations in the composition of this microbiota can lead to disease. Previously, we demonstrated that indigenous gut bacteria were required for the insecticidal toxin of Bacillus thuringiensis to kill the gypsy moth, Lymantria dispar. ... | This study demonstrates that in some larval species, indigenous gut bacteria contribute to B. thuringiensis susceptibility. Moreover, the contribution of enteric bacteria to host mortality suggests that perturbations caused by toxin feeding induce otherwise benign gut bacteria to exert pathogenic effects. The interacti... | yes |
19,247,024 | Is pretreatment T3-4 stage an adverse prognostic factor in patients with esophageal squamous cell carcinoma who achieve pathological complete response following preoperative chemoradiotherapy? | {
"contexts": [
"Preoperative chemoradiotherapy (CRT) followed by esophagectomy is becoming one of the standard treatment strategies for esophageal cancer. Pathologic complete response (pCR) after CRT is the best predictor of survival in squamous cell carcinoma (SCC) of the esophagus. Although no adjuvant treatme... | We have shown that up to 31.4% of patients with esophageal SCC who achieve pCR develop tumor recurrence thereafter. Pretherapy T3-4 disease was a strong and independent adverse risk factor for 5-year tumor recurrence, DSS and DFS. High-risk patients with T3-4 disease should be followed with a strict surveillance protoc... | yes |
19,255,154 | Does age-dependent disease expression determine remodeling of the retinal mosaic in carriers of RPGR exon ORF15 mutations? | {
"contexts": [
"To characterize the retinal histopathology in carriers of X-linked progressive retinal atrophy (XLPRA1 and XLPRA2), two canine models of X-linked retinitis pigmentosa caused, respectively, by a stop and a frameshift mutation in RPGRORF15.",
"Retinas of XLPRA2 and XLPRA1 carriers of different ... | The time of onset and the progression of the disease differed between the two models. In the early-onset form (XLPRA2) the morphologic appearance of the retinal mosaic changed as a function of age, suggesting that structural plasticity persists in the early postnatal canine retina as mutant photoreceptors die. In the l... | yes |
19,255,156 | Does amniotic membrane transplantation induce apoptosis in T lymphocytes in murine corneas with experimental herpetic stromal keratitis? | {
"contexts": [
"To investigate the effect of human amniotic membrane transplantation (AMT) on T-cell immune response in murine corneas with herpetic stromal keratitis (HSK).",
"Herpes simplex virus (HSV)-1-infected BALB/c mice with necrotizing HSK were treated with AMT. CD3(+) cell apoptosis was determined i... | The results suggest that murine HSK improves after AMT through reduced local T-helper cell immune responses by inducing apoptosis in T lymphocytes, independently of passive apoptosis or activation-induced cell death. AM also reduces local T-helper cytokine and chemokine levels but does not result in immune deviation. I... | yes |
19,267,924 | Does thrombin increase inflammatory cytokine and angiogenic growth factor secretion in human adipose cells in vitro? | {
"contexts": [
"Abdominal obesity is associated with pro-thrombotic and inflammatory states. Therefore, the purpose of this study was to examine the expression of thrombin receptors (PAR1 and PAR4) human adipose tissue and whether thrombin stimulates an inflammatory cytokine and growth factor profile in human ad... | Here we show that thrombin PAR1 and PAR4 receptors are present and that thrombin stimulates inflammatory cytokine generation and growth factor release in human adipose tissue and cells in vitro. These data suggest that thrombin may represent a molecular link between obesity and associated inflammation. | yes |
19,267,921 | Are the high affinity selectin glycan ligand C2-O-sLex and mRNA transcripts of the core 2 beta-1,6-N-acetylglucosaminyltransferase ( C2GnT1 ) gene highly expressed in human colorectal adenocarcinomas? | {
"contexts": [
"The metastasis of cancer cells and leukocyte extravasation into inflamed tissues share common features. Specialized carbohydrates modified with sialyl Lewis x (sLex) antigens on leukocyte membranes are ligands for selectin adhesion molecules on activated vascular endothelial cells at inflammatory... | C2-O-sLex, detected by the CHO-131 mAb, is a tumor associated antigen whose expression is highly upregulated in colorectal adenocarcinomas and metastatic liver tumors compared to normal tissues. C2-O-sLex is a potentially useful early predictor of metastasis. | yes |
19,272,385 | Is interleukin-17 a critical mediator of vaccine-induced reduction of Helicobacter infection in the mouse model? | {
"contexts": [
"Despite the proven ability of immunization to reduce Helicobacter infection in mouse models, the precise mechanism of protection has remained elusive. This study explores the possibility that interleukin (IL)-17 plays a role in the reduction of Helicobacter infection following vaccination of wild... | IL-17 plays a critical role in the immunization-induced reduction of Helicobacter infection from the gastric mucosa. | yes |
19,275,503 | Are novel serum paraoxonase activity assays associated with coronary artery disease? | {
"contexts": [
"Serum paraoxonase (PON1) exerts antiatherogenic effects. Novel PON1 enzymatic tests have been recently developed: 5-thiobutyl butyrolactone (TBBL) estimates PON1 lactonase activity, whereas 7-O-diethylphosphoryl-3-cyano-4-methyl-7-hydroxycoumarin (DEPCyMC) is considered a surrogate marker of PON1... | Novel PON1 activity assays may be associated with CAD. In this study, CAD patients had low DEPCyMCase activity, a possible marker of low PON1 concentration, but showed a high stimulation of PON1 lactonase activity. | yes |
19,245,968 | Does anger-induced T-wave alternans predict future ventricular arrhythmias in patients with implantable cardioverter-defibrillators? | {
"contexts": [
"This study sought to determine whether T-wave alternans (TWA) induced by anger in a laboratory setting predicts future ventricular arrhythmias in patients with implantable cardioverter-defibrillators (ICDs).",
"Anger can precipitate spontaneous ventricular tachycardia/ventricular fibrillation... | Anger-induced TWA predicts future ventricular arrhythmias in patients with ICDs, suggesting that emotion-induced repolarization instability may be 1 mechanism linking stress and sudden death. Whether there is a clinical role for anger-induced TWA testing requires further study. | yes |
19,247,757 | Does intranasal lidocaine plus naphazoline nitrate improve surgical conditions and perioperative analgesia in septorhinoplasty surgery? | {
"contexts": [
"Septorhinoplasty is a traumatic procedure that is associated with epistaxis and postoperative pain. The primary objective of this randomized double-blind controlled trial was to determine whether intranasal 5% lidocaine plus naphazoline decreases postoperative pain and lessens the use of rescue a... | Intranasal lidocaine plus naphazoline is a simple and efficient technique for decreasing intra- and postoperative pain and for lessening rescue analgesic requirements in the postoperative period after septorhinoplasty. Toxic plasma concentrations of lidocaine were not reached. | yes |
19,277,846 | Does sulforaphane inhibit TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells? | {
"contexts": [
"To investigate the effects of sulforaphane on endothelial inflammatory gene expression in endothelial cells.",
"Human aortic endothelial cells were used in the study.",
"One-hour pretreatment of endothelial cells (EC) with sulforaphane (1-4 muM) suppressed TNF-alpha-induced MCP-1 and VCAM... | These data suggest that sulforaphane may be useful as a therapeutic agent for the treatment of inflammatory diseases. | yes |
19,276,628 | Do adenosine A ( 1 ) receptors determine glomerular hyperfiltration and the salt paradox in early streptozotocin diabetes mellitus? | {
"contexts": [
"In early type 1 diabetes mellitus, changes in proximal reabsorption influence glomerular filtration rate (GFR) through tubuloglomerular feedback (TGF). Due to TGF, a primary increase in proximal reabsorption causes early diabetic hyperfiltration, while a heightened sensitivity of the proximal tub... | A(1)Rs determine glomerular hyperfiltration and the salt paradox in early diabetes, which is consistent with the tubulocentric principle. | yes |
19,255,374 | Do prevalence of psychiatric and substance use disorders among single mothers nearing lifetime welfare eligibility limits? | {
"contexts": [
"In the 1990s, US welfare reform legislation imposed a 5-year lifetime limit on financial support for low-income families with young children (younger than 18 years). With increasing numbers of single mothers and their children reaching the end of their welfare eligibility, there is concern about ... | Despite the high prevalence of psychiatric and substance use disorders in this population, many remain untreated. The consequences of terminating welfare assistance are worthy of further investigation, given the potential for adverse effects on both mothers and their young children. | yes |
19,261,566 | Does suicidal ideation and behavior and some psychological correlate in physically disabled motor-vehicle accident survivors? | {
"contexts": [
"Previous research has shown some maladaptive psychological reactions and even increased incidence of various mental disorders in patients with spinal cord injury during their rehabilitation. Self-concept and suicidal risk in particular have not been studied often in these samples.",
"Our prin... | While limited by small sample size, our study results support the need to further explore suicide risk and psychological correlates in patients with permanent physical disability. | yes |
19,246,300 | Is [ Risk of cerebral vasospasm following subarachnoid hemorrhage associated with endothelial nitric oxide synthase gene polymorphism ]? | {
"contexts": [
"To study whether endothelial nitric oxide synthase gene (eNOS) polymorphisms is implicated in the development of cerebral vasospasm following subarachnoid hemorrhage.",
"Three groups of patients with subarachnoid hemorrhage were selected to test this hypothesis, including 98 patients with cer... | The findings of the case-control and family-based studies clearly demonstrate that DNA sequence differences in eNOS gene influence the risk of cerebral vasospasm in subarachnoid hemorrhage. | yes |
19,250,292 | Does inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduce lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor kappaB? | {
"contexts": [
"Initiation and maintenance of pro-inflammatory reactions elicited by bacterial lipopolysaccharide and/or cytokines in the macrophage lineage have been reported to play a crucial role in acute and chronic pathogenic effects. Whether pro-inflammatory responses triggered by lipopolysaccharide in gro... | The findings of this study suggest that inhibition of cell-cycle progression is capable of reducing pro-inflammatory responses via down-regulation of NF-kappaB. | yes |
19,263,753 | Is accuracy of tobramycin levels obtained from central venous access devices in patients with cystic fibrosis technique dependent? | {
"contexts": [
"Patients with cystic fibrosis (CF) frequently require prolonged aminoglycoside antibiotic therapy administered via central venous access devices (CVADs). Therefore, the effect of the volume of saline flush used prior to drawing blood on tobramycin levels obtained from CVADs was investigated to de... | Peak tobramycin levels drawn from CVADs flushed with a small flush volume are falsely elevated compared to those obtained by peripheral venipuncture. The use of a larger saline flush greatly improves the accuracy of these levels. Therefore, care should be taken to base clinical decisions on tobramycin levels obtained b... | yes |
19,262,409 | Does prolonged head down bed rest-induced inactivity impair tonic autonomic regulation while sparing oscillatory cardiovascular rhythms in healthy humans? | {
"contexts": [
"Physical inactivity represents a major risk for cardiovascular disorders, such as hypertension, myocardial infarction or sudden death; however, underlying mechanisms are not clearly elucidated. Clinical and epidemiological investigations suggest, beyond molecular changes, the possibility of an in... | Prolonged inactivity as induced by HDBR in healthy volunteers reduces both cardiovagal and vascular sympathetic regulation, while largely maintaining peripheral responsiveness to standardized stimuli and sparing the functional structure of central oscillatory cardiovascular regulation. | yes |
19,268,941 | Does human C-reactive protein induce endothelial dysfunction and uncoupling of eNOS in vivo? | {
"contexts": [
"Elevated C-reactive protein (CRP) levels are associated with increased cardiovascular events and endothelial dysfunction. We have previously shown that CRP decreases endothelial nitric oxide synthase (eNOS) activity in endothelial cells and inhibits endothelium-dependent nitric oxide (NO)-mediate... | Our data provide novel evidence for the detrimental action of CRP in vivo by impairing eNOS-dependent vasodilation and uncoupling of eNOS. | yes |
19,251,091 | Does peroxiredoxin IV protect cells from radiation-induced apoptosis in head-and-neck squamous cell carcinoma? | {
"contexts": [
"Human peroxiredoxins (Prxs) are known as a family of thiol-specific antioxidant enzymes, among which Prx-I and -II play an important role in protecting cells from irradiation-induced cell death. It is not known whether Prx-IV also protects cells from ionizing radiation (IR).",
"To evaluate th... | The results of these studies suggest that Prx-IV may play an important role in protecting cells from IR-induced apoptosis in head-and-neck squamous cell carcinoma. | yes |
19,251,093 | Does inhibition of 4E-BP1 sensitize U87 glioblastoma xenograft tumors to irradiation by decreasing hypoxia tolerance? | {
"contexts": [
"Eukaryotic initiation factor 4E (eIF4E) is an essential rate-limiting factor for cap-dependent translation in eukaryotic cells. Elevated eIF4E activity is common in many human tumors and is associated with disease progression. The growth-promoting effects of eIF4E are in turn negatively regulated... | Our results suggest that although tumors often demonstrate increases in cap-dependent translation, regulation of this activity is required to facilitate energy conservation, hypoxia tolerance, and tumor radioresistance. Furthermore, we suggest that targeting translational control may be an effective way to target hypox... | yes |
19,250,553 | Are the conserved WW-domain binding sites in Dystroglycan C-terminus essential but partially redundant for Dystroglycan function? | {
"contexts": [
"Dystroglycan (Dg) is a transmembrane protein that is a part of the Dystrophin Glycoprotein Complex (DGC) which connects the extracellular matrix to the actin cytoskeleton. The C-terminal end of Dg contains a number of putative SH3, SH2 and WW domain binding sites. The most C-terminal PPXY motif h... | Based on the obtained results we propose that the presence of the two WW binding sites in Dystroglycan secures the essential interaction between Dg and Dys and might further provide additional regulation for the cytoskeletal interactions of this complex. | yes |
19,247,540 | Is muscle strength significantly associated with hip bone mineral density in women with Parkinson 's disease : a cross-sectional study? | {
"contexts": [
"To study the influence of physical impairments on hip bone mineral density in women with Parkinson's disease.",
"Cross-sectional study.",
"Thirty-four women with Parkinson's disease and 30 age-matched healthy controls.",
"Patients with Parkinson's disease underwent a hip scan using du... | Hip bone mineral density is independently associated with leg muscle strength in women with Parkinson's disease. | yes |
19,263,524 | Is inter-alpha-trypsin inhibitor heavy chain 4 a novel marker of acute ischemic stroke? | {
"contexts": [
"Inflammation and inflammatory markers play an important role in acute ischemic stroke (AIS). In an earlier study, we discovered a 120-kDa protein that was highly expressed in healthy participants, but either was not expressed or was barely expressed in AIS patients. The purpose of the present wor... | ITIH4 is an anti-inflammatory protein, and suggests that further investigation into its potential use in the diagnosis and prognosis of AIS is warranted. | yes |
19,263,526 | Are single nucleotide polymorphisms of vascular endothelial growth factor gene intron 2 markers for early progression of diabetic retinopathy in Japanese with type 1 diabetes? | {
"contexts": [
"Few studies investigated the relationship between single nucleotide polymorphisms (SNPs) of vascular endothelial growth factor (VEGF) gene and time to the development and progression of diabetic retinopathy.",
"Eight SNPs of VEGF gene were typed using TaqMan assays in 175 Japanese patients wi... | Certain SNPs in intron 2 of the VEGF gene are associated with early progression of retinopathy in Japanese patients with type 1 diabetes, though their contributions were weakened by glycemic exposure. | yes |
19,272,800 | Is the epithelial-mesenchymal transition-inducing factor TWIST an attractive target in advanced and/or metastatic bladder and prostate cancers? | {
"contexts": [
"Metastasis remains the main cause of death in both bladder (BCa) and prostate (PCa) cancers. The results of chemotherapy did not show any significant improvement of the survival the past years. Cancer research has led to the identification of signaling pathways involved and molecular targets that... | With the targeted therapy, oncology has entered into a new era, which is going to be critical in cancer treatment in combination with traditional anticancer drugs. | yes |
19,272,804 | Are the oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells mediated by survivin and modulated by the NSAID sulindac? | {
"contexts": [
"Constitutive activation of the signal transducer and activator of transcription 3 (Stat3) has been detected in various human cancers and has been linked to tumor development and progression. Oncogenic Stat3 signaling results in induction of specific target genes, among which survivin is implicate... | Taken together, these data support the importance of the constitutive Stat3 signaling for growth and survival of salivary gland cancer cells through the induction of survivin. Inhibition of the oncogenic Stat3-survivin pathway in these cells can be achieved by selective targeting techniques or treatment with the NSAID ... | yes |
19,248,780 | Does the Apc 1322T mouse develop severe polyposis associated with submaximal nuclear beta-catenin expression? | {
"contexts": [
"We previously demonstrated that the 2 APC mutations in human colorectal tumors are coselected, because tumorigenesis requires an optimal level of Wnt signaling. We and others subsequently showed that the truncated APC proteins in colorectal tumors usually retain a total of 1-2 beta-catenin bindin... | We propose that the Apc(1322T) mutation produces submaximal beta-catenin levels that promote early tumor growth more effectively than the Apc(Min) mutation. | yes |
19,273,703 | Does diagnostic assay based on hsa-miR-205 expression distinguish squamous from nonsquamous non-small-cell lung carcinoma? | {
"contexts": [
"Recent advances in treatment of lung cancer require greater accuracy in the subclassification of non-small-cell lung cancer (NSCLC). Targeted therapies which inhibit tumor angiogenesis pose higher risk for adverse response in cases of squamous cell carcinoma. Interobserver variability and the lac... | Hsa-miR-205 is a highly accurate marker for lung cancer of squamous histology. The standardized diagnostic assay presented here can provide highly accurate subclassification of NSCLC patients. | yes |
19,252,142 | Does strength training preserve the bone mineral density of postmenopausal women without hormone replacement therapy? | {
"contexts": [
"The study was designed to evaluate the effects of strength training (ST) on the bone mineral density (BMD) of postmenopausal women without hormone replacement therapy.",
"Subjects were randomized into untrained (UN) or trained (TR) groups. The TR group exercised three ST sessions per week for... | Results indicated that 24 weeks of ST improved body composition parameters, increased muscular strength, and preserved BMD in postmenopausal women. | yes |
19,253,814 | Do objective findings with malpositioning of a nucleus 24RE ( CA ) cochlear implant? | {
"contexts": [
"Proper intracochlear placement of cochlear implant electrode arrays is believed to be important for optimum speech perception results. However, objective tests of cochlear implant function typically provide little or no information about the intracochlear placement of the array. We report the res... | Although the electrode array had folded up on itself during insertion, intraoperative electrode impedances and VIII nerve responses, as well as postoperative electrically evoked auditory brainstem responses, were within normal limits. However, averaged electrode voltages, obtained with the Nucleus Crystal Integrity Tes... | yes |
19,273,450 | Are mannose-binding lectin gene polymorphisms associated with disease activity and physical disability in untreated , anti-cyclic citrullinated peptide-positive patients with early rheumatoid arthritis? | {
"contexts": [
"To study the association between polymorphisms in the mannose-binding lectin gene (MBL2) and disease activity, physical disability, and joint erosions in patients with newly diagnosed rheumatoid arthritis (RA).",
"Patients with early RA (n=158) not previously treated with disease modifying an... | The results point to a synovitis-enhancing effect of MBL in anti-CCP-positive RA, whereas such an effect was not demonstrated for joint erosions. | yes |
19,258,076 | Is surgical treatment decisive for outcome in chondrosarcoma of the chest wall : a population-based Scandinavian Sarcoma Group study of 106 patients? | {
"contexts": [
"Chondrosarcoma of the chest wall is the most frequent primary malignant chest wall tumor. Surgery remains the only effective treatment. Sarcoma treatment in Sweden is centralized to sarcoma centers; however, sarcomas of the chest wall have also been handled by thoracic and general surgeons.",
... | Patients operated with wide surgical margins resulted in fewer local recurrences and better overall survival. Patients with chest wall tumors should be referred to sarcoma centers and not to general thoracic surgery clinics for diagnosis and treatment. | yes |
19,258,070 | Does expression of LKB1 tumor suppressor in non-small cell lung cancer determine sensitivity to 2-deoxyglucose? | {
"contexts": [
"Targeted therapy promises to improve patient outcome in non-small cell lung cancer. Biomarkers can direct targeted therapy toward patients who are most likely to respond, thus optimizing benefit. A novel agent with antineoplastic potential is the glucose analog, 2-deoxyglucose. 2-Deoxyglucose tar... | LKB1 loss increases susceptibility to 2-deoxyglucose treatment in non-small cell lung cancer lines, even at low doses. Thus, determination of LKB1 status may help direct therapy to those patients most likely to benefit from this novel approach, making it useful in the treatment of patients with non-small cell lung canc... | yes |
19,276,286 | Does sunitinib mediate reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients? | {
"contexts": [
"Immune dysfunction reported in renal cell carcinoma (RCC) patients may contribute to tumor progression. Myeloid-derived suppressor cells (MDSC) represent one mechanism by which tumors induce T-cell suppression. Several factors pivotal to the accumulation of MDSC are targeted by the tyrosine kinas... | Sunitinib-based therapy has the potential to modulate antitumor immunity by reversing MDSC-mediated tumor-induced immunosuppression. | yes |
19,276,289 | Is sperm-derived SPANX-B a clinically relevant tumor antigen that is expressed in human tumors and readily recognized by human CD4+ and CD8+ T cells? | {
"contexts": [
"The sperm-derived SPANX family proteins can be found expressed in human tumors. Here, we aimed to perform a comprehensive study to evaluate immunotherapeutic relevance of one of its members, SPANX-B. We wanted to test its expression pattern in human tumors and to evaluate CD4(+) and CD8(+) T-cell... | SPANX-B is an immunogenic sperm-derived antigen that is expressed in several human tumors. SPANX-B is also efficiently recognized by the human T-cell immune arm, indicating its significant value for the development of protective and therapeutic cancer vaccines. | yes |
19,247,038 | Does lipid-rich enteral nutrition reduce postoperative ileus in rats via activation of cholecystokinin-receptors? | {
"contexts": [
"This study investigates the effect of lipid-rich nutrition on the local inflammatory response and gastrointestinal hypomotility in a rat model of postoperative ileus.",
"Postoperative ileus is a major clinical problem, in which inflammation of the intestinal muscularis plays a key pathogenic ... | Our data demonstrate that nutritional stimulation of the autonomic nervous system with enteral lipids reduces postoperative ileus by inhibition of inflammation. Clinically, lipid-rich enteral nutrition may be a new therapeutic option in the treatment of postoperative ileus. | yes |
19,272,788 | Does wall motion score index predict mortality and functional result after surgical ventricular restoration for advanced ischemic heart failure? | {
"contexts": [
"Advanced ischemic heart failure can be treated with surgical ventricular restoration (SVR). While numerous risk factors for mortality and recurrent heart failure have been identified, no plain predictor for identifying SVR patients with left ventricular damage beyond recovery is yet available. We... | Sufficient residual remote myocardium is necessary to recover from a SVR procedure and to translate the surgically induced morphological changes into a functional improvement. Preoperative WMSI is a surrogate measure of residual remote myocardial function and is a promising tool for better patient selection to improve ... | yes |
19,270,312 | Does ciprofloxacin select for multidrug resistance in Salmonella enterica serovar Typhimurium mediated by at least two different pathways? | {
"contexts": [
"The aim of this study was to understand the role of ramA in conferring multidrug resistance (MDR) in Salmonella enterica serovar Typhimurium.",
"Two phenotypically distinct isogenic MDR laboratory mutants derived from Salmonella Typhimurium SL1344 and three human clinical isolates from a pati... | These data show that ciprofloxacin exposure can select for mutations within ramR and consequently mediate MDR. These data also indicate that there is at least one further unidentified gene in addition to marA, soxS, rob and ramA that confers MDR in S. enterica. | yes |
19,270,316 | Is high serum YKL-40 concentration associated with cardiovascular and all-cause mortality in patients with stable coronary artery disease? | {
"contexts": [
"Macrophages in atherosclerotic plaques secrete YKL-40. We tested the hypothesis if high serum YKL-40 concentration predicts coronary events and death of patients with stable coronary artery disease (CAD).",
"During the 2.6 years follow-up period (median 2.77 year, interquartile range 0.23 yea... | High serum YKL-40 is associated with MI, cardiovascular and all-cause mortality in patients with stable CAD. | yes |
19,269,720 | Are muscle cramps the commonest side effect of home parenteral nutrition? | {
"contexts": [
"Complications resulting from home parenteral nutrition (HPN) reduce a patient's quality of life. The major complications of catheter-related sepsis, venous thrombosis and chronic liver disease are well recognised. This study aimed to determine if there were other minor, but common complications t... | Muscle cramps have a high prevalence in patients receiving home parenteral nutrition. | yes |
19,274,082 | Is genetic variation in ATP5O associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins? | {
"contexts": [
"Impaired oxidative capacity of skeletal muscle mitochondria contribute to insulin resistance and type 2 diabetes (T2D). Furthermore, mRNA expression of genes involved in oxidative phosphorylation, including ATP5O, is reduced in skeletal muscle from T2D patients. Our aims were to investigate mecha... | Genetic variation and age are associated with skeletal muscle ATP5O mRNA expression and glucose disposal rate, suggesting that combinations of genetic and non-genetic factors may cause the reduced expression of ATP5O in T2D muscle. These findings propose a role for ATP5O, in cooperation with other OXPHOS genes, in the ... | yes |
19,258,100 | Is contractile function preserved in unloaded hearts despite atrophic remodeling? | {
"contexts": [
"Recent studies have shown that mechanically unloading a failing heart may induce reverse remodeling and functional improvement. However, these benefits may be balanced by an unloading-related remodeling including myocardial atrophy that might lead to decrease in function. Using a model of heterot... | Atrophic remodeling involves both the myocyte and interstitial tissue compartment. These data suggest that although there is decreased myocardial volume and increased stiffness, contractile capacity is preserved in the long-term unloaded heart. | yes |
19,267,361 | Is nadir CA-125 level an independent prognostic factor in advanced epithelial ovarian cancer? | {
"contexts": [
"The purpose of this study was to determine the independency of a nadir CA-125 level as a prognostic factor in patients with advanced epithelial ovarian cancer (EOC).",
"Among the 153 women with advanced EOC who had surgery in our hospital between January 2001 and June 2007, 121 women underwen... | The prognostic role of the nadir CA-125 is independent of residual tumor size in the patients with advanced EOC. However, it is still unclear whether maximal surgical effort can affect the nadir CA-125 levels. | yes |
19,277,235 | Does analysis with support vector machine show HIV-positive subjects without infectious retinitis have mfERG deficiencies compared to normal eyes? | {
"contexts": [
"To test the following hypotheses: (1) eyes from individuals with human immunodeficiency virus (HIV) have electrophysiologic abnormalities that manifest as multifocal electroretinogram (mfERG) abnormalities; (2) the retinal effects of HIV in immune-competent HIV individuals differ from the effects... | This study confirms that mfERG SOK abnormalities develop in the retina of HIV-positive individuals. The new finding of equal severity of b-latency abnormalities in the low- and high-CD4 groups indicates that good immune status under highly active antiretroviral therapy may not protect against retinal damage and, by ext... | yes |
19,276,261 | Does microRNA-21 regulate the proliferation and invasion in esophageal squamous cell carcinoma? | {
"contexts": [
"MicroRNAs are approximately 22 nucleotide noncoding RNA molecules that posttranscriptionally regulate gene expression. The aim of this study was (a) to determine a role of microRNA-21 in esophageal squamous cell carcinoma and (b) to elucidate the regulation of the programmed cell death 4 (PDCD4) ... | MicroRNA-21 targets PDCD4 at the posttranscriptional level and regulates cell proliferation and invasion in esophageal squamous cell carcinoma. It may serve as a novel therapeutic target in esophageal squamous cell carcinoma. | yes |
19,270,735 | Do mMPs regulate both development and immunity in the tribolium model insect? | {
"contexts": [
"Matrix metalloproteinases (MMPs) are evolutionarily conserved and multifunctional effector molecules in development and homeostasis. In spite of previous, intensive investigation in vitro and in cell culture, their pleiotrophic functions in vivo are still not well understood.",
"We show that ... | This is the first study, to our knowledge, investigating the in vivo role of virtually all insect MMP paralogs along with their inhibitors TIMP and RECK in both insect development and immunity. Our results from the Tribolium model insect indicate that MMPs regulate tracheal and gut development during beetle embryogenes... | yes |
19,245,917 | Does anatomic location of penetrating lower-extremity trauma predict compartment syndrome development? | {
"contexts": [
"Compartment syndrome of the lower extremity can be a difficult diagnosis to make with serious consequences if diagnosis and intervention is delayed. Identifying patients who are more likely to develop this syndrome can help prevent the associated complications. The purpose of this study was to ev... | Injuries to the proximal half of the BK segment are the most common cause for the development of compartment syndrome from penetrating injuries of the lower extremity. Development of BK compartment syndrome because of penetrating AK injury is rare without an associated surgically significant vascular injury. Observatio... | yes |
19,270,740 | Does physically active lifestyle decrease the risk of fattening? | {
"contexts": [
"Increasing age is associated with declining physical activity and a gain in fat mass. The objective was to observe the consequence of the age-associated reduction in physical activity for the maintenance of energy balance as reflected in the fat store of the body.",
"Young adults were observe... | The change from a physically active to a more sedentary routine does not induce an equivalent reduction of energy intake and requires cognitive restriction to maintain energy balance. | no |
19,260,186 | Does performance-oriented mobility assessment ( POMA ) balance score indicate need for assistive device? | {
"contexts": [
"To determine (1) if older adults using an assistive device (AD) score lower on the Performance-Oriented Mobility Assessment (POMA) balance subscale (B-subscale) than individuals not using an AD; and (2) if a cut-score of 12 would indicate the need to use an AD.",
"Elderly persons (n = 82, mea... | Older adults using an AD will score lower on the B-subscale and report lower activity level and health status. A score of less than 12 on the B-subscale is indicative of AD need. Older adults who use an AD and self-report a falls history will score lower on the B-subscale than individuals using an AD and no reported hi... | yes |
19,246,475 | Does brain nuclear factor-kappa B activation contribute to neurohumoral excitation in angiotensin II-induced hypertension? | {
"contexts": [
"Angiotensin II (ANG II)-induced inflammatory and oxidative stress responses contribute to the pathogenesis of hypertension. In this study, we determined whether nuclear factor-kappa B (NF-kappaB) activation in the hypothalamic paraventricular nucleus (PVN) increases oxidative stress and contribut... | These findings suggest that an ANG II-induced increase in the brain renin-angiotensin system activates NF-kappaB in the PVN and contributes to sympathoexcitation in hypertension. The increased superoxide in the PVN contributes to NF-kappaB activation and neurohumoral excitation in hypertension. | yes |
19,247,264 | Does oxidative stress impair vasorelaxation induced by the soluble guanylyl cyclase activator BAY 41-2272 in spontaneously hypertensive rats? | {
"contexts": [
"BAY 41-2272 (5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine) relaxes mesenteric arteries (MA) in a synergistic fashion with nitric oxide (NO). We hypothesized that the relaxation to BAY 41-2272 is decreased in spontaneously hypertensive rats (SHR) because... | Augmented oxidative stress in SHR impaired cGMP-dependent and -independent relaxation induced by BAY 41-2272, by decreasing NO bioavailability and sGC expression and by increasing contractile activity. Inhibiton of oxidative stress improved the relaxation of BAY 41-2272 in SHR. BAY 41-2272 might be an alternative thera... | yes |
19,248,099 | Does cCAAT/enhancer binding protein beta mediate expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis? | {
"contexts": [
"To determine the function of CCAAT/enhancer binding protein beta (C/EBPbeta) in the expression of matrix metalloproteinase 13 (MMP-13) in chondrocytes in inflammatory arthritis.",
"Cartilage obtained from patients with rheumatoid arthritis and osteoarthritis was immunostained for expression o... | C/EBPbeta directly binds to the MMP-13 promoter region and stimulates the expression of MMP-13 in chondrocytes in inflammatory arthritis. | yes |
19,248,098 | Is membrane type 1 matrix metalloproteinase a crucial promoter of synovial invasion in human rheumatoid arthritis? | {
"contexts": [
"A hallmark of rheumatoid arthritis (RA) is invasion of the synovial pannus into cartilage, and this process requires degradation of the collagen matrix. The aim of this study was to explore the role of one of the collagen-degrading matrix metalloproteinases (MMPs), membrane type 1 MMP (MT1-MMP), ... | MT1-MMP serves as an essential collagen-degrading proteinase during pannus invasion in human RA. Specific inhibition of MT1-MMP-dependent invasion may represent a novel therapeutic strategy for RA. | yes |
19,265,830 | Are digital images obtained with a digital camera associated with a loss of critical information -- a preliminary study? | {
"contexts": [
"To investigate whether digital images obtained by a digital camera are deficient compared to the original radiographs.",
"Twenty pairs of bitewing radiographs of children and 40 anterior periapical radiographs were photographed using a digital camera. Images were saved as JPEG files and loade... | Storing existing radiographs in a digital medium for space saving purposes using a digital camera does not loose critical information.Clinical implication Clinicians can use digital cameras to digitise and store radiographic images without losing important diagnostic information. | no |
19,259,966 | Do medullary pain facilitating neurons mediate allodynia in headache-related pain? | {
"contexts": [
"To develop and validate a model of cutaneous allodynia triggered by dural inflammation for pain associated with headaches. To explore neural mechanisms underlying cephalic and extracephalic allodynia.",
"Inflammatory mediators (IM) were applied to the dura of unanesthetized rats via previousl... | Facial and hind-paw allodynia associated with dural stimulation is a useful surrogate of pain associated with primary headache including migraine and may be exploited mechanistically for development of novel therapeutic strategies for headache pain. The data also demonstrate the requirement for activation of descending... | yes |
19,254,290 | Are polymorphisms in interleukin-1 receptor-associated kinase 4 associated with total serum IgE? | {
"contexts": [
"Serum immunoglobulin E (IgE) level is recognized to be under strong genetic control, but the causal and susceptibility genes remain to be identified. We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total... | These results demonstrate a clear association between polymorphisms in the IRAK4 gene and serum IgE levels in patients with CRS and asthma. IRAK4 may be important in the regulation of IgE levels in patients with inflammatory diseases of the airways. | yes |
19,263,123 | Is electronic endoscope insertion into a thoracic drainage tube a new technique in the treatment and diagnosis of pleural diseases? | {
"contexts": [
"Pleural disease remains a commonly encountered clinical problem for both physician and surgeon. This study describes a new way to better diagnose and treat pleural diseases (hemothorax, empyema, and pleural effusion) using an electronic endoscope (gastroscope or bronchoscope).",
"We conducted... | The technique of inserting an electronic endoscope into the thoracic drainage tube for diagnosis and treatment of pleural diseases is simple, effective, minimally invasive, and cost-effective. | yes |
19,277,114 | Does a novel endo-hydrogenase activity recycle hydrogen produced by nitrogen fixation? | {
"contexts": [
"Nitrogen (N(2)) fixation also yields hydrogen (H(2)) at 1:1 stoichiometric amounts. In aerobic diazotrophic (able to grow on N(2) as sole N-source) bacteria, orthodox respiratory hupSL-encoded hydrogenase activity, associated with the cell membrane but facing the periplasm (exo-hydrogenase), has ... | Representative of aerobic N(2)-fixing and H(2)-recycling alpha-proteobacteria, A. caulinodans possesses two respiratory Ni,Fe-hydrogenases: HupSL exo-hydrogenase activity drives exogenous H(2) respiration, and Hyq endo-hydrogenase activity recycles endogenous H(2), specifically that produced by N(2) fixation. To benefi... | yes |
19,247,449 | Does eWS/ETS regulate the expression of the Dickkopf family in Ewing family tumor cells? | {
"contexts": [
"The Dickkopf (DKK) family comprises a set of proteins that function as regulators of Wnt/beta-catenin signaling and has a crucial role in development. Recent studies have revealed the involvement of this family in tumorigenesis, however their role in tumorigenesis is still remained unclear.",
... | Our results suggested that DKK2 could not functionally substitute for DKK1 tumor-suppressive effect in EFT. Given the mutually exclusive expression of DKK1 and DKK2, EWS/ETS regulates the transcription of the DKK family, and the EWS/ETS-mediated DKK2 up-regulation could affect the tumorigenicity of EFT in an indirect m... | yes |
19,246,317 | Do [ Intravenous injection rate and site of fentanyl affect the incidence and onset time of fentanyl-induced cough ]? | {
"contexts": [
"To explore the effect of intravenous injection rate and site of fentanyl on the incidence and onset time of fentanyl-induced cough.",
"Seventy-five ASA class I or II patients were randomized into 3 groups and received intravenous fentanyl administration at 4 microg/kg in different manners. In... | The rate of fentanyl injection through the same peripheral venous access at the same dose may affect the incidence and onset time of cough. At the same dose and injection rate of fentanyl, forearm venous access of injection resulted in earlier onset of cough than lower limb venous access, but the incidence is similar. | yes |
19,259,653 | Is cYP2C19 genotype associated with symptomatic recurrence of GERD during maintenance therapy with low-dose lansoprazole? | {
"contexts": [
"Maintenance therapy of gastroesophageal reflux disease (GERD) is usually performed with a low dose of a proton-pump inhibitor (PPI). Because PPIs are metabolized by CYP2C19 in the liver, we investigated whether a patient's CYP2C19 genotype was associated with symptomatic recurrence of GERD during... | When the dose of lansoprazole is decreased, the RM genotype of CYP2C19 appears to be a risk factor for symptomatic recurrence of GERD. The CYP2C19 genotyping test would be useful for determining the optimal dose of a PPI for maintenance therapy of GERD. | yes |
19,251,245 | Does co-treatment with diazepam prevent the effects of fluoxetine on the proliferation and survival of hippocampal dentate granule cells? | {
"contexts": [
"Selective serotonin reuptake inhibitors (SSRI) often produce increased anxiety during the first weeks of treatment before the clinical antidepressant response, and these symptoms are commonly treated with benzodiazepines. Selective serotonin reuptake inhibitors increase proliferation of neuronal ... | These results suggest that benzodiazepines might interfere with the clinical effects of fluoxetine or that increased neurogenesis is not a valid model for the delayed onset of the clinical antidepressant effects. | yes |
19,260,859 | Are endometrial osteopontin mRNA expression and plasma osteopontin levels increased in patients with endometriosis? | {
"contexts": [
"The aim of this study was to evaluate osteopontin (OPN) mRNA expression in eutopic endometrium and plasma OPN levels in patients with endometriosis.",
"A total of 79 patients with histologically confirmed endometriosis and 43 patients without endometriosis participated in this study. OPN mRNA... | Osteopontin may be involved in the pathogenesis of endometriosis and plasma OPN may be a useful non-invasive marker for the diagnosis of endometriosis. | yes |
19,260,857 | Are changes in endometrial natural killer cell expression of CD94 , CD158a and CD158b associated with infertility? | {
"contexts": [
"Cycle-dependent fluctuations in natural killer (NK) cell populations in endometrium and circulation may differ, contributing to unexplained infertility.",
"NK cell phenotypes were determined by flow cytometry in endometrial biopsies and matched blood samples.",
"While circulating and endo... | In infertile women, changes in circulating NK cell percentages are found exclusively during the secretory phase and not in endometrium; cycle-related changes in NK receptor expression are observed only in infertile endometrium. While having exciting implications for understanding NK cell function in fertility, our data... | yes |
19,274,454 | Does glucose modulate event-related potential components of recollection and familiarity in healthy adolescents? | {
"contexts": [
"Behavioural evidence supports the notion that oral glucose ingestion enhances recognition memory judgements based on recollection, but not familiarity. The present study sought to clarify and extend upon these behavioural findings by investigating the influence of glucose administration on event-... | These findings (a) support the results of previous research that the 'glucose memory facilitation effect' can be extended to healthy adolescents, but (b) suggest that glucose enhances both the recollection and familiarity components of recognition memory. The observed ERP profile has important implications for the prop... | yes |
19,254,136 | Is ability of supragingival plaque to induce toll-like receptor 4-mediated stimulation associated with cytokine production by peripheral blood mononuclear cells? | {
"contexts": [
"In our previous study, we found that the ability of supragingival plaque to induce Toll-like receptor (TLR)4-mediated stimulation was positively associated with plaque score and bleeding on probing (BOP) at the sampled sites and that the ability to induce TLR2-mediated stimulation was negatively ... | The production of pro-/anti-inflammatory cytokines by PBMCs was associated with the ability of supragingival plaque to induce TLR4-mediated stimulation. The cytokines induced by supragingival plaque via TLR4 might modulate periodontal status. | yes |
19,250,544 | Is the multidrug resistance 1 ( MDR1 ) gene polymorphism G-rs3789243-A associated with disease susceptibility in Norwegian patients with colorectal adenoma and colorectal cancer ; a case control study? | {
"contexts": [
"Smoking, dietary factors, and alcohol consumption are known life style factors contributing to gastrointestinal carcinogenesis. Genetic variations in carcinogen handling may affect cancer risk. The multidrug resistance 1(MDR1/ABCB1) gene encodes the transport protein P-glycoprotein (a phase III x... | The MDR1 intron 3 (G-rs3789243-A) polymorphism was not associated with a risk of colorectal adenomas or carcinomas in the present Norwegian study group. Thus, this MDR1 polymorphism does not seem to play an important role in colorectal carcinogenesis in this population. | no |
19,250,546 | Is methylation of homeobox genes a frequent and early epigenetic event in breast cancer? | {
"contexts": [
"Aberrant methylation of CpG islands is a hallmark of cancer and occurs at an early stage in breast tumorigenesis. However, its impact on tumor development is not fully determined, and its potential as a diagnostic biomarker remains to be validated. Methylation profiling of invasive breast carcino... | We have identified a series of new potential methylation biomarkers that may help elucidate the underlying mechanisms of breast tumorigenesis. More specifically, our results are suggestive of a critical role of homeobox gene methylation in the insurgence and/or progression of breast cancer. | yes |
19,252,105 | Do parents ' reports predict abnormal investigations in global developmental delay? | {
"contexts": [
"To identify symptoms reported by parents that predict abnormal laboratory investigations in preschoolers with global developmental delay (GDD).",
"A cross-sectional descriptive study of 81 boys and 38 girls, with a mean age of 43.5 months (SD = 13.4), with global developmental delay. All pare... | Parent's reports predict abnormal tests and indicate quantifiable differences requiring investigation. | yes |
19,263,465 | Does stress affect carers before patient 's first visit to a memory clinic? | {
"contexts": [
"To measure and compare the burden on spousal carers of patients with and without dementia who were consulting a memory clinic for the first time.",
"We included 413 dyads of patients and their spousal carers consulting a memory clinic for the first time. Of them 276 had a diagnosis of Cogniti... | Carers of both CIND and dementia patients when attending a memory clinic for initial diagnostic assessment experience high levels of stress. Impaired function in ADL in patients is the strongest predictor of this stress. | yes |
19,263,462 | Is baculovirus an efficient vector for the transduction of the eye : comparison of baculovirus- and adenovirus-mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye? | {
"contexts": [
"The present study aimed to determine the efficiency and safety of baculovirus-mediated intravitreal gene transfer in rabbit eye and to compare its efficiency with adenovirus. We also studied how an intravitreal injection of vectors producing vascular endothelial growth factor D (VEGF-D) impacts t... | The study suggests that baculoviruses are efficient vectors for ocular gene transfer, especially if deeper retinal layers need to be transduced. In addition, intravitreal VEGF-D gene transfer caused blood-retina barrier breakdown but not neovessel formation in the rabbit eye. | yes |
19,262,738 | Does genome-wide profiling of histone h3 lysine 4 and lysine 27 trimethylation reveal an epigenetic signature in prostate carcinogenesis? | {
"contexts": [
"Increasing evidence implicates the critical roles of epigenetic regulation in cancer. Very recent reports indicate that global gene silencing in cancer is associated with specific epigenetic modifications. However, the relationship between epigenetic switches and more dynamic patterns of gene act... | This work offers a dynamic picture of epigenetic switches in carcinogenesis and contributes to an overall understanding of coordinated regulation of gene expression in cancer. Our data indicate an H3K4me3/H3K27me3 epigenetic signature of prostate carcinogenesis. | yes |
19,276,229 | Are polymorphisms of the scavenger receptor class B member 1 associated with insulin resistance with evidence of gene by sex interaction? | {
"contexts": [
"Genetic variation in diabetes-associated genes cumulatively explain little of the overall heritability of this trait. We sought to determine whether polymorphisms of the scavenger receptor class B, member I (SCARB1), an estrogen-regulated chromosome 12q24 positional candidate diabetes gene, were ... | Our data support an association between SCARB1 variants and insulin resistance, especially in women, with evidence of significant gene by sex interaction. These findings warrant further investigation in additional populations and prompt exploration of a role for SR-BI in the development of insulin resistance. | yes |
19,276,228 | Do progestin and thrombin regulate tissue factor expression in human term decidual cells? | {
"contexts": [
"Perivascular cell membrane-bound tissue factor (TF) initiates hemostasis via thrombin generation. The identity and potential regulation of TF-expressing cells at the human maternal-fetal interface that confers hemostatic protection during normal and preterm delivery is unclear.",
"The objecti... | In human term placental sections, DC-expressed TF exceeds that of other cell types at the maternal-fetal interface and is localized at the cell membranes in which it can bind to factor VII and meet the hemostatic demands of labor and delivery via thrombin formation. Unlike the general concept that TF is constitutive in... | yes |
19,272,063 | Does transfemoral snaring and stabilization of pacemaker and defibrillator lead to maintain vascular access during lead extraction? | {
"contexts": [
"Lead extraction is an effective method for removing pacemaker and defibrillator leads and to obtain venous access when central veins are occluded.",
"We report a series of patients who required lead extraction and preservation of vascular access requiring a vascular snare introduced from the ... | Our series demonstrates the simple and safe technique of transfemoral lead snaring to assist lead extraction and maintain vascular access in the setting of venous occlusion, when the distal lead tip pulls free of the myocardium before an extraction sheath is passed beyond the point of venous obstruction. | yes |
19,272,060 | Do the characteristics and distribution of the scar tissue predict ventricular tachycardia in patients with advanced heart failure? | {
"contexts": [
"Contrast-enhanced magnetic resonance imaging (CMR) identifies scar tissue as hyperenhanced areas. We sought to clarify the relationship between the scar characteristics and occurrence of sustained ventricular tachycardia (VT) in patients with advanced heart failure.",
"CMR was performed in 29... | The presence and magnitude of the nontransmural scar tissue may predict sustained VT in patients with advanced heart failure. There was the possibility that a recruitment bias was responsible for the finding of the smaller scars in the ICM patients with sustained VT. | yes |
19,246,876 | Are bronchoalveolar lavage fluid eosinophils correlated to natural killer cells in eosinophilic pneumonias? | {
"contexts": [
"Eosinophilic lung diseases comprise a group of heterogeneous pulmonary disorders linked by increased eosinophils in bronchoalveolar lavage fluid (BALF). There is supporting evidence that natural killer (NK) cells participate in the regulation of eosinophilic inflammation.",
"Our aim was to in... | Eosinophil inflammation seems to develop through a different pathway in EP compared to other ILDs. | yes |
19,261,025 | Does temporary malar augmentation help with preoperative planning for a permanent procedure? | {
"contexts": [
"Cheek augmentation improves the appearance of patients with flat malar eminences, creating a more youthful image. Autologous adipose tissue has been demonstrated to be a safe injectable filling material for malar augmentation.",
"Before proceeding to fat transplantation, a rapidly absorbable ... | A temporary malar augmentation could be performed before a potentially permanent procedure, particularly when the surgeon or patient is hesitant about the aesthetic results. | yes |
19,271,061 | Is lipoproteina ( a ) a feature of the presence , diffuseness , and severity of coronary artery disease in Saudi population? | {
"contexts": [
"To study lipoprotein(a) [Lp(a)] levels in Saudi patients with angiographically defined coronary artery disease and to see its relationship with its severity and diffuseness.",
"This cross sectional study was carried out at King Khalid University Hospital, Riyadh, Saudi Arabia in 2006-2007. On... | Lipoprotein(a) levels are significantly higher in Saudi patients with CAD compared to healthy individuals, and are associated with more severe and diffuse blockage of the coronary vessels. | yes |
19,266,571 | Does local delivery of glial cell line-derived neurotrophic factor improve facial nerve regeneration after late repair? | {
"contexts": [
"Facial nerve regeneration is limited in some clinical situations: in long grafts, by aged patients, and when the delay between nerve lesion and repair is prolonged. This deficient regeneration is due to the limited number of regenerating nerve fibers, their immaturity and the unresponsiveness of ... | GDNF is a potent neurotrophic factor to improve facial nerve regeneration in grafts performed several months after the nerve lesion. However, GDNF should not be used for immediate repair, as it possibly inhibits the nerve regeneration. | yes |
19,276,292 | Does sense of effort determine lower limb force production during dynamic movement in individuals with poststroke hemiparesis? | {
"contexts": [
"This study's purpose was to determine if individuals who have had a stroke primarily use sense of effort to gauge force production during static and dynamic lower limb contractions. If relying on sense of effort while attempting to generate equal limb forces, participants should produce equal per... | For both isometric and isotonic conditions hemiparetic participants relied primarily on sense of effort, rather than proprioceptive feedback, for gauging lower limb force production. This outcome indicates that sense of effort is the major factor determining force production during movements. Lower limb rehabilitation ... | yes |
19,250,983 | Does epidermal growth factor receptor activation protect gastric epithelial cells from Helicobacter pylori-induced apoptosis? | {
"contexts": [
"Helicobacter pylori infection disrupts the balance between gastric epithelial cell proliferation and apoptosis, which is likely to lower the threshold for the development of gastric adenocarcinoma. H pylori infection is associated with epidermal growth factor (EGF) receptor (EGFR) activation thro... | EGFR activation by H pylori infection has an antiapoptotic effect in gastric epithelial cells that appears to involve Akt signaling and Bcl family members. These findings provide important insights into the mechanisms of H pylori-associated tumorigenesis. | yes |
19,250,984 | Does iGF-1 moderate the time-dependent transcriptional patterns of key homeostatic genes induced by sustained compression of bovine cartilage? | {
"contexts": [
"To determine changes in chondrocyte transcription of a range of anabolic, catabolic and signaling genes following simultaneous treatment of cartilage with Insulin-like growth factor-1 (IGF-1) and ramp-and-hold mechanical compression, and compare with effects on biosynthesis.",
"Explant disks ... | Sustained compression markedly altered the effects of IGF-1 on expression of genes involved in cartilage homeostasis, while IGF-1 was largely unable to moderate the transcriptional effects of compression alone. The demonstrated co-expressed gene pairings suggest a balance of anabolic and catabolic activity following si... | no |
19,259,740 | Do serum matrilysin levels predict outcome in curatively resected colorectal cancer patients? | {
"contexts": [
"Matrix metalloproteinase 7 (MMP-7) is involved in invasion, metastasis, growth, and angiogenesis. The aim of this study is to assess the prognostic role of serum MMP-7 in curatively resected colorectal cancer (CRC).",
"Patients undergoing resection for CRC (n = 175) were recruited from July 2... | MMP-7 predicts recurrence in curatively resected CRC patients. | yes |
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