pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
19,258,213 | Is renal phenotype of ET-1 transgenic mice modulated by androgens? | {
"contexts": [
"Activation of the endothelin (ET) system promotes inflammation and fibrosis in various tissues including the kidney. Male ET-1 transgenic mice are characterized by chronic kidney inflammation and renal scarring. We hypothesized that this renal phenotype might be modulated by androgens. Thus the a... | Our study demonstrates that the renal histopathological phenotype in male ET-1 transgenic mice with regard to glomerulosclerosis, proteinuria, perivascular fibrosis and immune cell immigration is ameliorated by castration. We thus conclude that the effects of ET-1 overexpression on renal tissue injury are modulated by ... | yes |
19,274,524 | Is rho-kinase , but not protein kinase C , involved in generation of the spontaneous tone in the resting phase of the isolated pig iris sphincter muscle? | {
"contexts": [
"The purpose of the present study was to clarify the role of Rho-kinase and/or protein kinase C in the resting tension of the isolated pig iris sphincter muscle.",
"The motor activity of the isolated pig iris sphincter muscle was measured isometrically.",
"EGTA, a chelator of extracellular... | These results suggest that, in the isolated pig iris sphincter muscle, Rho-kinase plays an important role in the generation of spontaneous tone in the resting phase via the inhibition of MLCP activity. | yes |
19,274,525 | Does bimatoprost-induced calcium signaling in human T-cells involve prostanoid FP or TP receptors? | {
"contexts": [
"The prostamide bimatoprost and prostanoid FP receptor agonists are highly efficacious drugs for glaucoma treatment. The presence of both prostamide and prostanoid FP receptors in bimatoprost-sensitive preparations has made prostamide receptor classification difficult. This study investigated a no... | Molt-3 cells have been identified as a bimatoprost-sensitive preparation in which the activity of bimatoprost is independent of prostanoid FP receptors. | no |
19,274,522 | Does dynamic assessment of learning ability improve outcome prediction following acquired brain injury? | {
"contexts": [
"There is a need to improve the prediction of outcome following acquired brain injury. The previous focus has been on specifying the relative contribution of such variables as pre-morbid intellectual ability, socioeconomic status, severity of injury and performance on neuropsychological assessment... | It is concluded that dynamic testing potentially may offer advantages over the traditional standard cognitive tests in predicting the outcome for people with brain injuries. | yes |
19,246,720 | Do foxP3+ regulatory T cells suppress effector T-cell function at pathologic site in miliary tuberculosis? | {
"contexts": [
"The inadequacy of effector T-cell response in containment of tubercle bacilli is believed to result in the development of disseminated forms of tuberculosis (TB), such as miliary tuberculosis (MTB). Regulatory T cells (Treg) plausibly play a critical role in the immunopathogenesis of disseminated... | Our results highlight the importance of Treg cells in suppression of effector immune response and their influence on bacillary dissemination, disease manifestation, and severity. | yes |
19,254,135 | Do bone perforation and placement of collagen sponge facilitate bone augmentation? | {
"contexts": [
"Bone perforation may induce bone marrow cell migration into a collagen sponge onlay implant. This study investigated the efficacy of bone perforation and collagen sponge onlay placement with regard to new bone formation.",
"One hundred sixty femurs of 80 Wistar male rats were used in four gro... | The use of the FC-HAC sponge on the bone perforation area seemed to promote bone augmentation by possibly acting as a scaffold for the bone marrow cells as well as maintaining the space that is necessary for bone growth to occur. | yes |
19,248,109 | Does inhibition of interleukin-33 signaling attenuate the severity of experimental arthritis? | {
"contexts": [
"Interleukin-33 (IL-33; or, IL-1F11) was recently identified as the ligand of the IL-1 family receptor T1/ST2. The aim of this study was to examine IL-33 production in human and mouse joints and to investigate the role of IL-33 and T1/ST2 in experimental arthritis.",
"IL-33 expression was exam... | IL-33 is produced locally in inflamed joints, and neutralization of IL-33 signaling has a therapeutic effect on the course of arthritis. These observations suggest that locally produced IL-33 may contribute to the pathogenesis of joint inflammation and destruction. | yes |
19,274,638 | Is increased C-reactive protein associated with apathy : the Leiden 85-Plus Study? | {
"contexts": [
"Apathy has recently been recognized as a distinct clinical syndrome although it is difficult to differentiate from late life depression. In old age, apathy as a syndrome in itself and depression may have different etiologies. Inflammatory markers have been associated with depression in the elderl... | Higher CRP concentrations increased the risk of depression but not apathy in a community-based cohort of 85 years old subjects. This suggests that apathy and depression in old age have different etiologies. | no |
19,247,086 | Does induction chemoradiotherapy increase pleural and pericardial complications after esophagectomy for cancer? | {
"contexts": [
"Limited information is available on late complications of multimodality therapy for locally advanced esophageal cancer. This study focuses on postesophagectomy benign pleural and pericardial complications to determine their prevalence, temporal pattern, and treatment, and their association with i... | Benign pleural and pericardial complications occur surprisingly frequently after esophagectomy, particularly when induction chemoradiotherapy is employed. This must be factored into discussions of morbidity for multimodality treatment strategies for locally advanced esophageal cancer and should be considered distinct f... | yes |
19,258,984 | Does ultrasound improve the success rate of a sural nerve block at the ankle? | {
"contexts": [
": During ankle block performance, anesthetizing the sural nerve is important for generating complete anesthesia of the lateral aspect of the foot. We hypothesized that an ultrasound-guided perivascular approach, utilizing the lesser saphenous vein as a reference, would prove more successful than ... | : Ultrasound guidance using the lesser saphenous vein as a reference point results in a more complete and longer lasting sural nerve block than does a traditional approach using surface landmarks. | yes |
19,266,568 | Does lactobacillus fermentum CECT 5716 prevent and reverts intestinal damage on TNBS-induced colitis in mice? | {
"contexts": [
"Probiotics attenuate gut inflammation when administered before experimental colitis, but data on their effect after colitis induction are scarce. We aimed to evaluate the effects of Lactobacillus fermentum CECT 5716 on gut injury when administered either before or after trinitrobencene sulfonic a... | Pretreatment with L. fermentum CECT 5716 attenuates TNBS colitis, an effect that seems to be due to its antioxidant abilities. When administered after TNBS, this probiotic is also effective in accelerating colitis recovery, and this is associated with an enhanced Toll-like receptor function. | yes |
19,258,713 | Does decrease in adiponectin levels correlate to growth response in growth hormone-treated children? | {
"contexts": [
"Adiponectin is secreted by adipose tissue and circulates in human plasma at high levels. Decreased adiponectin levels are associated with insulin resistance and obesity. The aim of this study was to investigate whether changes in serum adiponectin levels are related to the growth response, insuli... | GH treatment in prepubertal children decreases serum adiponectin levels, and the decrease is correlated to the growth response. No correlations between adiponectin and insulin levels or insulin resistance were found. | yes |
19,258,714 | Does androgen receptor modulation affect longitudinal growth of cultured fetal rat metatarsal bones? | {
"contexts": [
"Systemic administration of the nonaromatizable androgen oxandrolone stimulates growth in girls with Turner syndrome and boys with a constitutional delay of growth and puberty. It is unknown if oxandrolone acts locally at the growth plate level to stimulate longitudinal bone growth.",
"Metatar... | Modulation of AR activity in the fetal rat growth plate does not affect linear bone growth. Extrapolating from these in vitro data, it could be speculated that oxandrolone stimulates longitudinal bone growth in treated children by acting indirectly rather than directly through AR activation in growth plate chondrocytes... | no |
19,266,358 | Is abnormal cervical cytology associated with increased nitric oxide release in the uterine cervix? | {
"contexts": [
"The human uterine cervix is capable of producing nitric oxide (NO). We studied the impact of cytological changes on the release of cervical NO.",
"Population-based case-control study.",
"City of Helsinki, Finland.",
"Cervical cytology tests and cervical fluid samples were collected in... | Cervical cell changes (suggestive of HPV infection) are accompanied by an increased release of NO in the human cervix. The significance of this finding remains uncertain, but in theory, increased release of NO could modify the outcome of cervical infection. | yes |
19,248,659 | Is strengthening of mass drug administration implementation required to eliminate lymphatic filariasis from India : an evaluation study? | {
"contexts": [
"The mass drug administration (MDA) is one of the strategies to eliminate lymphatic filariasis in India. Eleven districts are endemic for the disease in Madhya Pradesh state of India, which conduct MDA activities annually. A mid-term evaluation was conducted with the objectives to review the progr... | This evaluation study noted that MDA is restricted to tablet distribution only and the major issues of implementation in compliance, health education, side effect and morbidity management, and the logistics were not being given due attention. The implementation should be strengthened immediately in the MDA programme in... | yes |
19,266,496 | Does founder Fukutin mutation cause Walker-Warburg syndrome in four Ashkenazi Jewish families? | {
"contexts": [
"Walker-Warburg syndrome (WWS) is a genetically heterogeneous congenital muscular dystrophy caused by abnormal glycosylation of alpha-dystroglycan (alpha-DG) that is associated with brain malformations and eye anomalies. The Fukutin (FKTN) gene, which causes autosomal recessively inherited WWS is ... | These data suggest that the c.1167insA FKTN mutation described by us is a founder mutation that can be used to target diagnostic testing and carrier screening in the Ashkenazi Jewish population. | yes |
19,267,850 | Is erectile function in two-kidney , one-clip hypertensive rats maintained by a potential increase in nitric oxide production? | {
"contexts": [
"Hypertension is closely associated with erectile dysfunction (ED) as it has been observed in many experimental models of hypertension. Additionally, epidemiological studies show that approximately a third of hypertensive patients have ED.",
"To test the hypothesis that the two-kidney, one-cli... | These data suggest that hypertension and ED could be dissociated from high levels of blood pressure in some animal models of hypertension. Erectile function in 2K-1C hypertensive rats is maintained in spite of the increased Rho-kinase activity by increased NO signaling. | yes |
19,265,535 | Does comparative genomics of lactic acid bacteria reveal a niche-specific gene set? | {
"contexts": [
"The recently sequenced genome of Lactobacillus helveticus DPC4571 revealed a dairy organism with significant homology (75% of genes are homologous) to a probiotic bacteria Lb. acidophilus NCFM. This led us to hypothesise that a group of genes could be determined which could define an organism's n... | Comparative analysis revealed that if an organism had homologs to the dairy specific geneset, it probably came from a dairy environment, whilst if it had homologs to gut specific genes, it was highly likely to be of intestinal origin.We propose that this "barcode" of 9 genes will be a useful initial guide to researcher... | yes |
19,265,532 | Does suppression of RNA interference increase alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoes? | {
"contexts": [
"Arthropod-borne viruses (arboviruses) can persistently infect and cause limited damage to mosquito vectors. RNA interference (RNAi) is a mosquito antiviral response important in restricting RNA virus replication and has been shown to be active against some arboviruses. The goal of this study was ... | We show that RNAi is active in Ae. aegypti cell culture and that B2 protein inhibits RNAi in mosquito cells when expressed by a recombinant SINV. Also, SINV more efficiently replicates in mosquito cells when RNAi is inhibited. Finally, TE/3'2J/B2 kills mosquitoes in a dose-dependent manner independent of infection rout... | yes |
19,276,636 | Does muscovite reverse gastric gland atrophy and intestinal metaplasia by promoting cell proliferation in rats with atrophic gastritis? | {
"contexts": [
"To detect whether muscovite exerts its protective role in the progression of atrophic gastritis (AG) and evaluate the possible mechanism.",
"AG rats were established and then randomly divided into groups administrated with different doses of muscovite for 8 weeks. Histological changes in gast... | Muscovite could reverse gastric gland atrophy and intestinal metaplasia by promoting cell proliferation and revitalization in gastric mucosa in AG rats. | yes |
19,272,396 | Does sodium nitroprusside iontophoresis on the finger pad consistently increase skin blood flow in healthy controls and patients with systemic sclerosis? | {
"contexts": [
"Sodium nitroprusside (SNP) iontophoresis is a commonly used technique to assess non endothelium-dependent skin microvascular function in the forearm. However, the lack of data on the finger pad is a limitation when studying diseases affecting the digits (e.g. systemic sclerosis, SSc). We thus aim... | The iontophoresis of SNP leads to a consistent, non axon reflex-dependent, increase in cutaneous vascular conductance in the forearm, both in patients with SSc and in healthy controls. On the finger pad however, such hyperemia was not consistent. As a consequence, other tools should be considered to assess non endothel... | no |
19,255,016 | Do age and violent-content labels make video games forbidden fruits for youth? | {
"contexts": [
"To protect minors from exposure to video games with objectionable content (eg, violence and sex), the Pan European Game Information developed a classification system for video games (eg, 18+). We tested the hypothesis that this classification system may actually increase the attractiveness of gam... | Although the Pan European Game Information system was developed to protect youth from objectionable content, this system actually makes such games forbidden fruits. Pediatricians should be aware of this forbidden-fruit effect, because video games with objectionable content can have harmful effects on children and adole... | yes |
19,254,974 | Is flat-footedness a disadvantage for athletic performance in children aged 11 to 15 years? | {
"contexts": [
"Because the controversy about the relation of foot morphology and foot function is still present, we find it surprising that there are no studies published dealing with motor skills and athletic performance in flat-footed school children. Our aim in this study was to determine if there is an asso... | No disadvantages in sport performance originating from flat-footedness were confirmed. Children with flat and children with "normal" feet were equally successful at accomplishing all motor tests; thus, we suggest that there is no need for treatment of flexible flat feet with the sole purpose of improving athletic perfo... | no |
19,246,957 | Is bullying behavior related to suicide attempts but not to self-mutilation among psychiatric inpatient adolescents? | {
"contexts": [
"To investigate the association of bullying behavior with suicide attempts and self-mutilation among adolescents.",
"The study sample consisted of 508 Finnish adolescents (age 12-17 years) admitted to psychiatric inpatient care between April 2001 and March 2006. DSM-IV psychiatric diagnoses an... | Among girls, being bullied or bullying others are both potential risk factors for suicidal behavior. Psychiatric assessment and treatment should thus be considered not only for victims of bullying, but also for bullies. Suicide-prevention programs should also routinely include interventions to reduce bullying. However,... | yes |
19,246,953 | Do subjective benefits of sequential bilateral cochlear implantation in young children after 18 months of implant use? | {
"contexts": [
"To investigate the subjective benefits of bilateral cochlear implantation in 33 young children after 18 months of second implant use.",
"The Wurzburg questionnaire inquiring into a range of hearing functions was filled out by the parents. Additional data concerning the daily life and well-bei... | The results indicate a wide range of positive subjective changes associated with bilateral cochlear implantation, even in older children. This progress led to a better and easier communication and a better integration in the normal-hearing world. | yes |
19,254,671 | Does cholinergic stimulation improve autonomic and hemodynamic profile during dynamic exercise in patients with heart failure? | {
"contexts": [
"Parasympathetic dysfunction is an independent risk factor for mortality in heart failure for which there is no specific pharmacologic treatment. This article aims to determine the effect of pyridostigmine, an anticholinesterase agent, on the integrated physiologic responses to dynamic exercise in... | Pyridostigmine was well tolerated by heart failure patients, leading to improved hemodynamic profile during dynamic exercise. | yes |
19,254,679 | Is persistent smoking after a diagnosis of lung cancer associated with higher reported pain levels? | {
"contexts": [
"The purpose of this study was to evaluate the impact of smoking status after a diagnosis of lung cancer on reported pain levels. We conducted a telephone survey of patients with lung cancer identified from 4 participating sites between September 2004 and July 2006. Patients were asked to rate the... | This article examines the relationship between pain and persistent smoking in patients with lung cancer. Although more research is needed to understand the mechanisms that relate nicotine intake to pain and disease progression, physicians can promote smoking cessation in patients with lung cancer to improve health and ... | yes |
19,246,810 | Does hydrogen sulfide regulate cardiac function and structure in adriamycin-induced cardiomyopathy? | {
"contexts": [
"The present study was designed to investigate if hydrogen sulfide (H2S), a novel gasotransmitter, might have a regulatory effect on cardiac function and structure, as well as oxidative stress, in adriamycin (ADR)-induced cardiomyopathy.",
"Hemodynamic measurements, histopathological examinati... | Downregulation of endogenously-generated H2S is probably involved in the pathogenesis of ADR-induced cardiomyopathy, whereby H2S reduces lipid peroxidation, increases antioxidation, and inhibits oxidative stress injury. | yes |
19,246,812 | Is elevated arterial stiffness evaluated by brachial-ankle pulse wave velocity deleterious for the prognosis of patients with heart failure? | {
"contexts": [
"Arterial stiffness is used as an index of arteriosclerosis. The goal of this study was to clarify whether increased arterial stiffness, evaluated by measuring the brachial-ankle pulse wave velocity (baPWV), is a risk factor for the prognosis of heart failure (HF) patients.",
"After examinatio... | Elevated arterial stiffness is a risk factor for re-admission or cardiac death of HF patients. | yes |
19,253,105 | Is the reduction in pigment epithelium-derived factor a sign of malignancy in ovarian cancer expressing low-level of vascular endothelial growth factor? | {
"contexts": [
"Angiogenesis is a critical factor in the progression of solid tumors and metastasis. The aim of this study was to characterise the roles of angiogenic and anti-angiogenic factors on ovarian cancer.",
"The expression levels of vascular endothelial growth factor (VEGF, angiogenic factor) and pi... | The reduction in PEDF expression levels may be, in part, responsible for tumor malignancy in VEGF-L ovarian tumors. Furthermore, PEDF may be a useful marker of malignancy in VEGF-L ovarian tumors. | yes |
19,251,402 | Does roxithromycin inhibit chemokine-induced chemotaxis of Th1 and Th2 cells but regulatory T cells? | {
"contexts": [
"Roxithromycin (RXM), a 14-member macrolide antibiotic, has a variety of bioregulatory functions such as anti-inflammatory effects, anti-oxidant effects, and modulation of immune responses.",
"In this study, we analyzed the effect of RXM on chemokine-induced chemotaxis of Th1, Th2, and regulat... | These results imply that RXM exhibits bioregulatory function by influencing chemotaxis of Th1 and Th2 cells while leaving Treg cell migration unaffected. | yes |
19,252,174 | Is a high number of losses in 13q14 chromosome band associated with a worse outcome and biological differences in patients with B-cell chronic lymphoid leukemia? | {
"contexts": [
"Among patients with B-cell chronic lymphoid leukemia, those with 13q14 deletion have a favorable outcome. However, whether the percentage of cells with 13q- influences the prognosis or the biological characteristics of this disease is unknown. We analyzed the clinico-biological characteristics an... | Patients with B-cell chronic lymphoid leukemia with a high number of losses in 13q14 as the sole cytogenetic aberration at diagnosis display different clinical and biological features: short overall survival and time to first therapy as well as more proliferation and less apoptosis. A quantification of the number of ce... | yes |
19,260,470 | Does combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identify genes specifically overexpressed in tumor epithelia? | {
"contexts": [
"The precise details of pancreatic ductal adenocarcinoma (PDAC) pathogenesis are still insufficiently known, requiring the use of high-throughput methods. However, PDAC is especially difficult to study using microarrays due to its strong desmoplastic reaction, which involves a hyperproliferating s... | We improve on other microarray studies of PDAC by putting together the higher statistical power due to a larger number of samples with information about cell-type specific expression and patient survival. | yes |
19,260,479 | Does fibronectin promote invasiveness and focal adhesion kinase tyrosine phosphorylation of human colon cancer cell? | {
"contexts": [
"The study was designed to investigate a potential role and mechanisms of fibronectin in tyrosine phosphorylation of focal adhesion kinase (FAK) and invasiveness of colon cancer cells.",
"A colorectal cancer cell line, Colo320, was stimulated by fibronectin with gradient concentrations. Phosph... | Fibronectin can promote invasion of Colo320 cells, FAK tyrosine phosphorylation plays a key role in this process. Inhibition of FAK expression can inhibit colon cancer cell invasion. | yes |
19,255,722 | Does feG-COOH blunt eosinophilic airway inflammation in a feline model of allergic asthma? | {
"contexts": [
"This study investigated if feG-COOH would decrease allergen-induced airway inflammation.",
"Seven adult cats sensitised to Bermuda grass allergen (BGA) to induce an asthmatic phenotype.",
"Cats were randomized to receive either feG-COOH (1 mg/kg, PO) or placebo (saline 1 ml, PO) immediate... | These data indicate that a single dose of feG-COOH partially attenuates eosinophilic airway inflammation in experimental feline asthma. | yes |
19,249,757 | Is midline uterine defect size correlated with miscarriage of euploid embryos in recurrent cases? | {
"contexts": [
"To compare subsequent pregnancy outcomes after two or more miscarriages in patients with and without congenital uterine anomalies.",
"Case-control study.",
"Nagoya City University Hospital.",
"A total of 42 patients with a bicornuate or septate uterus and 1528 with normal uteri.",
... | Congenital uterine anomalies have a negative impact on reproductive outcome in couples with recurrent miscarriage and are associated with further miscarriage with a normal embryonic karyotype. The D/C ratio was found to have a predictive value for further miscarriages in recurrent cases. | yes |
19,269,246 | Is oral poliovirus vaccine type 3 from a patient with transverse myelitis neurovirulent in a transgenic mouse model? | {
"contexts": [
"It is accepted that oral poliovirus vaccine (OPV) can cause vaccine-associated paralytic poliomyelitis (VAPP) and that wild poliovirus infection can rarely present as transverse myelitis. It is therefore possible that OPV could cause transverse myelitis. We previously reported a case of transvers... | The report of an OPV strain from a transverse myelitis case being neurovirulent in an in vivo mouse model provides further evidence for a causal association between OPV and transverse myelitis. | yes |
19,251,718 | Do inflammatory protein levels and depression screening after coronary stenting predict major adverse coronary events? | {
"contexts": [
"Traditional risk factors cannot account for the majority of future major adverse coronary events (MACE) in patients diagnosed with heart disease. We examined levels of inflammatory proteins to be possible predictors of future MACE and physiological and psychological factors that initiate temporal... | Our results suggest that hsCRP, vascular cell adhesion molecule, and monocyte chemoattractant protein-1 levels, measured after coronary stent insertion in patients with coronary heart disease, are prognostic of future MACE. Furthermore, positive depression screening is an independent predictor of future MACE. | yes |
19,261,297 | Does surgical resident performance on a virtual reality simulator correlate with operating room performance? | {
"contexts": [
"To define the ability of a virtual reality (VR) simulator to reflect clinical skill in surgical residents, we compared clinical laparoscopic performance and contemporary lab performance during curricular VR skills training.",
"Nine postgraduate year (PGY) 1 and 2 surgical residents were asses... | These data indicate that time to task completion on a VR training device correlates with resident performance in the clinical operating room. Serial evaluations will determine if concurrent performance improvement over time can be demonstrated. | yes |
19,258,922 | Are bronchiolitis : age and previous wheezing episodes linked to viral etiology and atopic characteristics? | {
"contexts": [
": Diagnostic criteria for bronchiolitis are variable.",
": To study how the risk factors for recurrent wheezing and asthma vary by different definitions of bronchiolitis.",
": Viral etiology and atopic characteristics were studied in 259 hospitalized wheezing children (median age, 14 mont... | : In children with bronchiolitis, 2 clinical factors, age and number of previous wheezing episodes, are linked to inflammatory (atopy-related factors) and virologic risk factors of asthma (rhinovirus-associated disease). According to current US and UK guidelines, bronchiolitis includes wheezing children <24 months of a... | yes |
19,276,744 | Do low hematocrit levels increase intracranial pressure in an animal model of cryogenic brain injury? | {
"contexts": [
"Brain injury is responsible for significant morbidity and mortality in trauma patients, but controversy still exists over optimal fluid management for these patients. This study aimed to investigate the effects of acute hemodilution with hydroxyethyl starch (HES) or lactated Ringer's solution (LR... | Hemodilution to a low hematocrit level increases ICP and decreases CPP scores in dogs submitted to a cryogenic brain injury. These results suggest that excessive hemodilution to a hematocrit below 30% should be avoided in traumatic brain injury patients. | yes |
19,260,501 | Does combination therapy of siRNAs mediate greater suppression on hepatitis B virus cccDNA in HepG2.2.15 cell? | {
"contexts": [
"Hepatitis B virus (HBV) infection is a world-wide health problem. The major obstacles for current anti-HBV therapy are the low efficacy and the occurrence of drug resistant HBV mutations. Recent studies have demonstrated that combination therapy can enhance antiviral efficacy and overcome the sho... | Our results revealed that combination of siRNAs mediated a stronger inhibition on viral replication and antigen expression in HepG2.2.15 cells, especially, the amplification of cccDNA. | yes |
19,249,249 | Do elective laparoscopy for herald symptoms of mesenteric/internal hernia after laparoscopic Roux-en-Y gastric bypass? | {
"contexts": [
"Mesenteric internal hernia (MIH) is the most common cause of small bowel obstruction (SBO) after laparoscopic Roux-en-Y gastric bypass. Because MIH is a potentially life-threatening complication, we hypothesized that elective repair of MIH before developing acute SBO could decrease morbidity in t... | SBO due to MIH after laparoscopic Roux-en-Y gastric bypass is typically preceded by symptoms of intermittent obstruction. Patients who have these herald symptoms should promptly be offered elective laparoscopic exploration. Elective repair of MIH can be performed safely and expeditiously. | yes |
19,248,116 | Does interleukin-7 stimulate secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes? | {
"contexts": [
"S100A4 has been shown to be increased in osteoarthritic (OA) cartilage and to stimulate chondrocytes to produce matrix metalloproteinase 13 (MMP-13) through activation of the receptor for advanced glycation end products (RAGE). The aim of this study was to examine the mechanism of S100A4 secretio... | IL-7 stimulates chondrocyte secretion of S100A4 via activation of JAK/STAT signaling, and then S100A4 acts in an autocrine manner to stimulate MMP-13 production via RAGE. Since both IL-7 and S100A4 are up-regulated in OA cartilage and can stimulate MMP-13 production by chondrocytes, this signaling pathway could contrib... | yes |
19,248,119 | Is tumor necrosis factor alpha-induced interleukin-32 positively regulated via the Syk/protein kinase Cdelta/JNK pathway in rheumatoid synovial fibroblasts? | {
"contexts": [
"Interleukin-32 (IL-32) is a recently discovered cytokine that appears to play a critical role in human rheumatoid arthritis (RA). It is highly expressed in synovium and fibroblast-like synoviocytes (FLS) from RA patients, but not in patients with osteoarthritis (OA). This study was undertaken to ... | The present findings suggest that IL-32 may be a newly identified prognostic biomarker in RA, thereby adding valuable knowledge to the understanding of this disease. The results also demonstrate that the production of IL-32 in RA FLS is regulated by Syk/PKCdelta-mediated signaling events. | yes |
19,261,622 | Does p66ShcA modulate oxidative stress and survival of endothelial progenitor cells in response to high glucose? | {
"contexts": [
"A close relationship exists between hyperglycaemia, oxidative stress, and diabetic complications. In fact, high glucose (HG) determines the overproduction of reactive oxygen species (ROS) by the mitochondria. p66ShcA is a gene that regulates the apoptotic responses to oxidative stress. Indeed, p6... | p66ShcA deletion rescues the BM-derived EPCs defect induced by HG, indicating p66ShcA as a potential therapeutic target in diabetic vasculopathy. | yes |
19,248,097 | Is stromal cell-derived factor 1/CXCR4 signaling critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model? | {
"contexts": [
"Stromal cell-derived factor 1 (SDF-1; CXCL12/pre-B cell growth-stimulating factor) is a dominant chemokine in bone marrow and is known to be involved in inflammatory diseases, including rheumatoid arthritis. However, its role in bone repair remains unknown. The purpose of this study was to invest... | SDF-1 is induced in the periosteum of injured bone and promotes endochondral bone repair by recruiting mesenchymal stem cells to the site of injury. | yes |
19,255,514 | Do corr4A and VRT325 reduce the inflammatory response to P. aeruginosa in human cystic fibrosis airway epithelial cells? | {
"contexts": [
"P. aeruginosa chronically colonizes the lung in CF patients and elicits a proinflammatory response. Excessive secretion of IL-6 and IL-8 by CF airway cells in response to P. aeruginosa infection in the CF airway is though to contribute to lung injury. Accordingly, the goal of this study was to te... | Corr4a and VRT325 do not reduce the inflammatory response to P. aeruginosa in human cystic fibrosis airway epithelial cells. | no |
19,264,838 | Does cancer survivors ' rehabilitation need in a primary health care context? | {
"contexts": [
"Studies of cancer survivors' rehabilitation needs have mostly addressed specific areas of needs, e.g. physical aspects and/or rehabilitation needs in relation to specific cancer types.",
"To assess cancer survivors' perceived need for physical and psychosocial rehabilitation, whether these ne... | Cancer survivors have many psychosocial rehabilitation needs and intervention should effectively target these needs. If this task is assigned to the GPs, they need to be proactive when assessing psychosocial aspects. | yes |
19,251,937 | Does radiofrequency ablation induce antigen-presenting cell infiltration and amplification of weak tumor-induced immunity? | {
"contexts": [
"To evaluate the influence of subtotal radiofrequency (RF) ablation on a tumor-specific immune response in a murine tumor model and to explore the role of intratumoral dendritic cells (ITDCs) in mediating this effect.",
"Animal work was performed according to an approved protocol and in compli... | Subtotal RF ablation treatment results in enhanced systemic antitumor T-cell immune responses and tumor regression that is associated with increased dendritic cell infiltration. ITDC injection mimics the RF ablation effect but does not increase immune responses when injected immediately after RF ablation. | yes |
19,277,602 | Does pioglitazone enhance the effectiveness of lifestyle modification in preventing conversion of impaired glucose tolerance to diabetes in Asian Indians : results of the Indian Diabetes Prevention Programme-2 ( IDPP-2 )? | {
"contexts": [
"The objective of this prevention programme was to study whether combining pioglitazone with lifestyle modification would enhance the efficacy of lifestyle modification in preventing type 2 diabetes in Asian Indians with impaired glucose tolerance.",
"In a community-based, placebo-controlled 3... | Despite good adherence to lifestyle modification and drug therapy, no additional effect of pioglitazone was seen above that achieved with placebo. The effectiveness of the intervention in both groups was comparable with that of lifestyle modification alone, as reported from the Indian Diabetes Prevention Programme-1. T... | no |
19,277,609 | Do inhibition of casein kinase I epsilon/delta produces phase shifts in the circadian rhythms of Cynomolgus monkeys? | {
"contexts": [
"Circadian rhythms in mammals depend upon the cyclic oscillations of transcriptional/translational feedback loops in pacemaker cells of the suprachiasmatic nucleus. The rise and fall of clock-related proteins is a function of synthesis and degradation, the latter involving phosphorylation by casei... | Consolidated bouts of activity were noted during periods of light with a repeating period length of roughly 24 h based on their onset. Reassessment in constant dim light (42 vs. 450 lx) again yielded period lengths of 24 h, in this instance revealing the animals' endogenous rhythm. PF-670462 (10-100 mg/kg s.c.) produce... | yes |
19,265,316 | Do [ Predictors of nursing service need for nursing homes residents ]? | {
"contexts": [
"The purposes of this study were to explore the functional status of elderly residents and to analyze time use, and finally identify factors to predict nursing care needs in relation to functional status and health related variables.",
"In this study a descriptive-correlational design was used... | Identifying factors that result in variations of service need has implications for adequate nursing service, estimation of optimum nurse to patient ratio, quality of care and patient safety. | yes |
19,254,376 | Does paracrine sonic hedgehog signalling by prostate cancer cells induce osteoblast differentiation? | {
"contexts": [
"Sonic hedgehog (Shh) and components of its signalling pathway have been identified in human prostate carcinoma and increased levels of their expression appear to correlate with disease progression and metastasis. The mechanism through which Shh signalling could promote metastasis in bone, the mos... | Altogether, these data demonstrate that Shh-expressing prostate cancer cells can directly and specifically induce differentiation in pre-osteoblasts via a Gli1-dependent mechanism that does not require transcriptional upregulation of Runx2. Paracrine activation of the Shh pathway in osteoblast progenitors and subsequen... | yes |
19,254,375 | Do cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos? | {
"contexts": [
"The centrosome is the cell's microtubule organising centre, an organelle with important roles in cell division, migration and polarity. However, cells can divide and flies can, for a large part of development, develop without them. Many centrosome proteins have been identified but the roles of mo... | Cep70 and Cep131 contribute to ciliogenesis in many tissues in the zebrafish embryo: cilia are made in cep70 and cep131 morphant zebrafish embryos but are shortened. We propose that the role of these centrosomal/basal body proteins is in making the cilium and that they are involved in determination of the length of the... | yes |
19,246,937 | Does blockade of nitric oxide synthesis modulate rat immunoglobulin A? | {
"contexts": [
"Nitric oxide (NO) is known as a regulator of inflammation and immunity. The purpose of this study was to investigate the influence of this signal molecule on the rat immunoglobulin A (IgA) system using Nomega-nitro-L-arginine-methyl ester (L-NAME), which inhibits the activity of all isoforms of N... | Obtained findings imply that endogenous NO may modulate the IgA system in the rat. | yes |
19,262,228 | Are ethnic differences in proximal and distal tubular sodium reabsorption heritable in black and white populations? | {
"contexts": [
"Segmental handling of sodium along the proximal and distal nephron might be heritable and different between black and white participants.",
"We randomly recruited 95 nuclear families of black South African ancestry and 103 nuclear families of white Belgian ancestry. We measured the (FENa) and... | Segmental sodium reabsorption along the nephron is highly heritable, but the capacity for regulation in the proximal and postproximal tubules differs between whites and blacks. | yes |
19,265,790 | Is cognitive impairment related to increased arterial stiffness and microvascular damage in patients with never-treated essential hypertension? | {
"contexts": [
"It is known that essential hypertension may be implicated in the development of cognitive impairment that is associated to microvascular disease of the brain. It has been hypothesized that increased arterial stiffness of the large arteries may lead to microvascular changes due to increased pulsat... | Impaired cognitive function is associated with increased large artery stiffness and microalbumin excretion in newly diagnosed, untreated hypertensive patients. These findings support the hypothesis that cognitive impairment induced by impaired microcirculation is linked to large artery stiffness and microvascular damag... | yes |
19,272,573 | Does music reduce patient anxiety during interfacility ground critical care transport? | {
"contexts": [
"Interfacility ground critical care transport (CCT) of patients by ambulance may be stressful. This study evaluated whether playing music during CCT reduces patient anxiety and whether objective evidence is manifested by a change in vital signs.",
"Urban teaching hospital.",
"In this prosp... | Music therapy is a simple adjunct for use during CCT that may increase patient comfort and alleviate anxiety. The small number of patients in this preliminary report limits the strength of any conclusions. Larger studies are needed. | yes |
19,248,640 | Do [ Phamacoeconomic analysis of antibiotics use in the Clinical Center of Vojvodina ]? | {
"contexts": [
"The investigation was performed in three phases and included all patients hospitalized at eight selected clinics known to be the biggest antibiotic spenders in the Clinical center of Vojvodina.",
"The first phase comprised retrospective evaluation of the total antibiotic use in therapy of all... | In the third phase, (three-month period in 2007/2008), the guidelines were implemented in therapy of bacterial infections. In this period, only by implementing the guidelines for initial adequate antimicrobial therapy, the therapy costs savings were 2027018.52 dinars (12.8%) at four of eight investigated clinics, compa... | yes |
19,274,111 | Does crude aqueous extract of the root bark of zanthoxylum xanthoxyloides inhibit white blood cells migration in acute inflammation? | {
"contexts": [
"Crude aqueous extract of Zanthoxylum xanthozyloides is used locally to treat inflammatory conditions. Previous study confirmed that the extract has anti-inflammatory activity and also reduced vascular response in inflammation.",
"To identify the effect of the extract on migration of white blo... | The extract did not affect the pre-existing WBC population at the site of inflammation but rather inhibited migration of the cells to the site. | yes |
19,254,999 | Do pain symptoms and stooling patterns drive diagnostic costs for children with functional abdominal pain and irritable bowel syndrome in primary or tertiary care? | {
"contexts": [
"The objectives of this study were to (1) compare the cost of medical evaluation for children with functional abdominal pain or irritable bowel syndrome brought to a pediatric gastroenterologist versus children who remained in the care of their pediatrician, (2) compare symptom characteristics for... | Despite the lack of difference in symptom characteristics between children in primary and tertiary care, a notable differential in cost of evaluation exists in accordance with level of care. Symptom characteristics do not seem to drive diagnostic evaluation in either primary or tertiary care. Given the lack of differen... | no |
19,254,810 | Is the glucocorticoid receptor heterocomplex gene STIP1 associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids? | {
"contexts": [
"Corticosteroids exert their anti-inflammatory action by binding and activating the intracellular glucocorticoid receptor heterocomplex.",
"We sought to evaluate the genes HSPCB, HSPCA, STIP1, HSPA8, DNAJB1, PTGES3, FKBP5, and FKBP4 on corticosteroid response.",
"White asthmatic subjects (... | STIP1 genetic variations might play a role in regulating corticosteroid response in asthmatic subjects with reduced lung function. Replication in a second asthmatic population is required to confirm these observations. | yes |
19,265,529 | Does living in rural New England amplify the risk of depression in patients with HIV? | {
"contexts": [
"The importance of depression as a complication of HIV infection is increasingly understood, and people living in rural areas are at increased risk for depression. However, it is not known whether living in rural areas amplifies the risk of depression in patients with HIV.",
"We compared the p... | HIV-infected patients living in rural areas, particularly those on antiretroviral therapy, are highly vulnerable to depression. | yes |
19,265,521 | Is assortative mating among Lake Malawi cichlid fish populations simply predictable from male nuptial colour? | {
"contexts": [
"Research on the evolution of reproductive isolation in African cichlid fishes has largely focussed on the role of male colours and female mate choice. Here, we tested predictions from the hypothesis that allopatric divergence in male colour is associated with corresponding divergence in preferenc... | We suggest that non-visual cues, such as olfactory signals, may play an important role in mate choice and behavioural isolation in these and perhaps other African cichlid fish. Future speciation models aimed at explaining African cichlid radiations may therefore consider incorporating such mating cues in mate choice sc... | no |
19,251,215 | Is increased cycle length during long-duration ventricular fibrillation caused by decreased upstroke velocity as well as prolonged refractoriness? | {
"contexts": [
"Cycle length (CL) increases as ventricular fibrillation (VF) progresses.",
"The purpose of this study was to test the hypotheses that increased CL is due to increased diastolic interval (DI), not increased action potential duration (APD), and that the DI increase is not solely due to increase... | Increasing CL in VF is due to increased DI and not APD, which shortens. The increase in DI(min) over time is much less than the increase in mean DI, indicating that the myocardium is excitable during much of the DI. This finding, along with the ability to pace at a CL shorter than the native VF CL and the poor paced wa... | yes |
19,252,749 | Does x box-binding protein 1 regulate angiogenesis in human pancreatic adenocarcinomas? | {
"contexts": [
"Tumors encounter endoplasmic reticulum stress during tumor growth and activate an adaptive pathway known as the unfolded protein response (UPR). Because this pathway is induced by the tumor microenvironment, it is a promising target for cancer therapy. We have previously demonstrated that X-box b... | We propose that the IRE1alpha-XBP-1 branch of the UPR modulates a complex proangiogenic, VEGF-independent response that depends on signals received from the tumor microenvironment. | yes |
19,272,386 | Does release of endogenous opioids from duodenal enteroendocrine cells require Trpm5? | {
"contexts": [
"Enteroendocrine cells, the largest and most diverse population of mammalian endocrine cells, comprise a number of different cell types in the gut mucosa that produce, store, and secrete small molecules, peptides, and/or larger proteins that regulate many aspects of gut physiology. Little is known... | Solitary chemosensory cells that coexpress beta-endorphin, Met-enkephalin, uroguanylin, and Trpm5 exist in mouse duodenum. These cells are likely to secrete the bioactive peptides into the intestinal lumen in response to dietary factors; release of the opioid peptides requires the Trpm5 ion channel. | yes |
19,272,387 | Do extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori? | {
"contexts": [
"Helicobacter pylori infects half of the world's population, thereby causing significant human morbidity and mortality. The mechanisms by which professional antigen-presenting cells recognize the microbe are poorly understood.",
"Using dendritic cells (DCs) from TRIF, MyD88, TLR 2/4/7/9(-/-), ... | These results provide novel comprehensive insights into the mechanisms of H pylori recognition by DCs. Understanding these processes provides a basis for the rational design of new vaccination strategies. | yes |
19,260,949 | Is serum paraoxonase-I activity unaffected by short-term administration of simvastatin , bezafibrate , and their combination in type 2 diabetes mellitus? | {
"contexts": [
"The high-density lipoprotein (HDL)-associated anti-oxidative and anti-inflammatory enzyme, paraoxonase-I, has been found previously to be lower in type 2 diabetes mellitus. We studied whether statin and fibrate treatment, alone and in combination, affect serum paraoxonase-I activity in conjunctio... | Short-term administration of simvastatin and bezafibrate, even when combined, is ineffective in raising serum paraoxonase-I activity in type 2 diabetes. | yes |
19,251,398 | Does soybean diet modulate acetyl-coenzyme A carboxylase expression in livers of rats recovering from early-life malnutrition? | {
"contexts": [
"The present study evaluated the effect of nutritional recovery with a soybean diet on the gene and protein expressions and protein phosphorylation of several enzymes and transcription factors involved in hepatic lipid metabolism.",
"Rats from mothers fed with 17% or 6% protein (casein) during... | Thus, the soybean diet reduced the liver lipid concentration through downregulation of the ACC gene and protein expressions rather than by phosphorylation status, which possibly resulted in decreased lipogenesis and increased beta-oxidation. | yes |
19,251,397 | Does early and prolonged intake of partially hydrogenated fat alter the expression of genes in rat adipose tissue? | {
"contexts": [
"Our previous study indicated that partially hydrogenated fat (PHF) diets, rich in trans-isomers, alter plasma lipids and increase the lipogenesis rate on adipose tissue in rats at a young age. In the present study we investigated the effects of dietary PHF on the expression of genes associated wi... | Prolonged intake of PHF has a negative effect on the expression of genes in RET when compared with diets with omega-6 and omega-3 PUFAs. These changes may be an effect of the smaller proportions of PUFAs in this fat, instead of being only caused by trans-fatty acids. | yes |
19,251,394 | Does oral glutamine protect against cyclophosphamide-induced cardiotoxicity in experimental rats through increase of cardiac glutathione? | {
"contexts": [
"This study evaluated the effects of supplemental oral glutamine (GLN) on acute cardiotoxicity of cyclophosphamide (CPA) in experimental rats. The dose-related cardiotoxicity of CPA is associated with a rapid decrease in cardiac glutathione (GSH) and oxidative cardiac injury. GLN is a rate-limitin... | These data suggest that GLN may protect against CPA-related cardiac injury through maintenance of cardiac GSH metabolism. | yes |
19,275,099 | Do [ Screening human keratinocyte growth factor mimic peptide with Ph.D.-7 phage display peptide library ]? | {
"contexts": [
"To harvest human keratinocyte growth factor (KGF) mimic peptides with Ph.D.-7 phage display peptide library.",
"Ph.D.-7 phage display peptide library was biopanned for 4 rounds to harvest monoclonal anti-body human KGF and then phage titer was detected. ELISA detection was performed to detect... | The phage mimic peptides resembling or related to human KGF DNA can be harvested from Ph.D.-7 phage display peptide library, which may be conducive to improve human KGF performance, wound healing and the quality of tissue engineered skin substitutes. | yes |
19,248,955 | Do petromastoid canal and cochlear aqueduct in cochlear implant candidates? | {
"contexts": [
"To present temporal bone fine channels in cochlear implantation candidates.",
"Review of the axial sections of 108 temporal bone CTs. In type I, the petromastoid canal (PMC) was invisible but appeared as channels in type II and type III, <0.5 and 0.5-1 mm wide, respectively, and in type IV wa... | It is likely that the age-related changes in CA and PMC are attributable to the developmental or age-related changes in skull base growth. | yes |
19,246,925 | Does two-stage portal vein ligation facilitate liver regeneration in rats? | {
"contexts": [
"Recent reports have demonstrated that some patients are unable to undergo scheduled liver resection after preoperative portal vein embolization due to insufficient hypertrophy of the future remnant liver. The present study examined whether two-stage portal vein ligation (PVL) increases hypertroph... | Two-stage PVL increases hypertrophy of the future remnant liver compared to conventional PVL in rats. | yes |
19,266,101 | Are low adiponectin levels an independent predictor of mixed and non-calcified coronary atherosclerotic plaques? | {
"contexts": [
"Atherosclerosis is the primary cause of coronary artery disease (CAD). There is increasing recognition that lesion composition rather than size determines the acute complications of atherosclerotic disease. Low serum adiponectin levels were reported to be associated with coronary artery disease a... | Adiponectin levels predict mixed and non-calcified coronary atherosclerotic plaque burden. Low adiponectin levels may contribute to coronary plaque vulnerability and may thus play a role in the pathophysiology of ACS. | yes |
19,255,035 | Does neonatal watershed brain injury on magnetic resonance imaging correlate with verbal IQ at 4 years? | {
"contexts": [
"We have previously described patterns of neonatal brain injury that correlate with global cognitive and motor outcomes. We now examine, in survivors of neonatal encephalopathy (presumed secondary to hypoxia-ischemia) without functional motor deficits, whether the severity and neuroanatomical invo... | In survivors of neonatal encephalopathy without functional motor deficits at 4 years of age, an increasing severity of watershed-distribution injury is associated with more impaired language-related abilities. | yes |
19,268,536 | Does curcumin prevent diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB? | {
"contexts": [
"Diabetic nephropathy is a debilitating disease that leads to end-stage renal failure in the Western world. Hyperglycemia is the initiating factor in several chronic diabetic complications which mediates increased oxidative stress and eventually the increased production of vasoactive factors and e... | These beneficial effects of curcumin were mediated through the inhibition of p300 and nuclear factor-kappaB. | yes |
19,253,110 | Is quality of life impairment during the female menopausal transition related to personal and partner factors? | {
"contexts": [
"To assess the female quality of life (QoL) during the menopausal transition and determine factors (personal and partner) related to its impairment. The frequency of menopausal symptoms was also assessed.",
"In this cross-sectional study, healthy women aged 40-59 years were asked to fill out t... | A high rate of middle-aged women in this series presented impaired QoL associated to female age and hormonal status and additionally to partner's health and sexual behavior. | yes |
19,251,013 | Does duration of the interval between the completion of bowel preparation and the start of colonoscopy predict bowel-preparation quality? | {
"contexts": [
"Recent studies suggest that colonoscopies done in the morning have better-quality bowel preparations than those done in the afternoon.",
"We aimed to determine how the duration of the interval between the end of the preparation and the start of the colonoscopy affects preparation quality.",
... | We used a nonvalidated scale to assess the quality of bowel preparation. | yes |
19,273,551 | Does oral antioxidant supplementation prevent acute mountain sickness : double blind , randomized placebo-controlled trial? | {
"contexts": [
"Acute mountain sickness may be caused by cerebrovascular fluid leakage due to oxidative damage to the endothelium. This may be reduced by oral antioxidant supplementation.",
"To assess the effectiveness of antioxidant supplementation for the prevention of acute mountain sickness (AMS).",
... | This trial found no evidence of benefit from antioxidant supplementation at high altitude. | no |
19,251,434 | Are cytokines and systemic biomarkers related to the size of abdominal aortic aneurysms? | {
"contexts": [
"The etiology of abdominal aortic aneurysm (AAA) includes atherosclerotic, inflammatory, immunological and coagulatory mechanisms. The aim of this study was to evaluate associations between markers for some of these mechanisms and AAA-size, in order to identify markers which might later be evaluat... | Many of the analyzed biomarkers were markedly increased in AAA-patients and some were also related to aneurysm size. Whether any of the markers is also associated with aneurysm growth rate should be further evaluated. | yes |
19,268,934 | Does 15-Epi-lipoxin A ( 4 ) inhibit the progression of endometriosis in a murine model? | {
"contexts": [
"To examine the pro-resolution actions of 15-epi-lipoxin A(4) (LXA(4)) on endometriotic lesions, on the concentrations and activities of matrix metalloproteinases (MMP-2 and MMP-9) in murine endometriosis.",
"Prospective, vehicle-controlled experimental study.",
"Animal research facility."... | LXA(4) may inhibit the progression of endometriosis possibly by lowering the concentrations and the activities of MMP-2 and MMP-9. | yes |
19,261,082 | Is elevated canine pancreatic lipase immunoreactivity concentration in dogs with inflammatory bowel disease associated with a negative outcome? | {
"contexts": [
"To investigate whether elevated canine pancreatic lipase immunoreactivity (CPLI) concentrations in dogs with inflammatory bowel disease (IBD) is associated with a worse clinical outcome.",
"Serum CPLI assays were performed on serum stored from cases diagnosed with IBD. Thirty-two dogs with CP... | CPLI should be measured in cases of canine IBD as elevated CPLI was associated with a worse outcome. | yes |
19,258,911 | Is mood associated with snoring in preschool-aged children? | {
"contexts": [
"To study emotional and behavioral problems and sleep and cognitive performance in snoring and nonsnoring 3- to 6-year-old children.",
"As part of an epidemiological study of sleep disordered breathing (SDB) in preschool-aged children, 43 snorers and 46 nonsnorers participated in a clinical st... | Our results support the view that SDB should be considered a possible risk factor for mood disorder symptoms and impaired cognitive performance in children. | yes |
19,258,917 | Do combinations of growth factors enhance the potency of islets in vitro? | {
"contexts": [
"Recent studies have demonstrated the impressive expansion of beta cells in vitro. But unfortunately, expanded beta cells do not function in the same way as fully differentiated beta cells. Therefore, we developed a condition that would allow islet cells to proliferate while maintaining their endo... | These findings suggest that adult beta cells have the potential to proliferate while maintaining their endocrine function, which can be improved through careful regulation of proliferation and differentiation. | yes |
19,274,752 | Does extracellular matrix modulate sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis? | {
"contexts": [
"Hepatocytes in culture are a valuable tool to investigate mechanisms involved in the response of the liver to cytokines. However, it is well established that hepatocytes cultured on monolayers of dried stiff collagen dedifferentiate, losing specialized liver functions. In this study, we show that... | Hepatocytes can exist in a differentiated and a dedifferentiated state that are reversible and can be switched by manipulating the responsible key factors of the signaling network. | yes |
19,248,120 | Does triggering of proteinase-activated receptor 4 lead to joint pain and inflammation in mice? | {
"contexts": [
"To investigate the role of proteinase-activated receptor 4 (PAR-4) in mediating joint inflammation and pain in mice.",
"Knee joint blood flow, edema, and pain sensitivity (as induced by thermal and mechanical stimuli) were assessed in C57BL/6 mice following intraarticular injection of either ... | This study demonstrates that local activation of PAR-4 leads to proinflammatory changes in the knee joint that are dependent on the kallikrein-kinin system. We also show for the first time that PARs are involved in the modulation of joint pain, with PAR-4 being pronociceptive in this tissue. Thus, blockade of articular... | yes |
19,252,908 | Does fDG PET imaging of Ela1-myc mice reveal major biological differences between pancreatic acinar and ductal tumours? | {
"contexts": [
"The aim was to evaluate FDG PET imaging in Ela1-myc mice, a pancreatic cancer model resulting in the development of tumours with either acinar or mixed acinar-ductal phenotype.",
"Transversal and longitudinal FDG PET studies were conducted; selected tissue samples were subjected to autoradiog... | In Ela1-myc mice, ductal tumours incorporate significantly more FDG than acinar tumours. This difference likely results from differential expression of Glut2 and hexokinases. These findings reveal previously unreported biological differences between acinar and ductal pancreatic tumours. | yes |
19,268,266 | Does oral diosmectite reduce stool output and diarrhea duration in children with acute watery diarrhea? | {
"contexts": [
"Diosmectite is a clay used to treat children with acute watery diarrhea. However, its effects on stool output reduction, the key outcome for pediatric antidiarrheal drugs, have not been shown.",
"Two parallel, double-blind studies of diosmectite efficacy on stool reduction were conducted in c... | These results show that diosmectite significantly decreased stool output in children with acute watery diarrhea, especially those who were rotavirus-positive. | yes |
19,270,436 | Does static stretch induce active morphological remodeling and functional impairment of alveolar epithelial cells? | {
"contexts": [
"Static stretch is frequently observed in the lung. Both static stretch and cyclic stretch can induce cell death and Na(+)/K(+)-ATPase trafficking, but stretch-induced alveolar epithelial cell (AEC) functions are much less responsive to static than to cyclic stretch. AEC remodeling under static st... | Under static stretch conditions, A549 cells undergo morphological and functional changes. They can survive stress failure from overstretching by remodeling their body to 'escape' the injury. During this complex course of remodeling, cellular function was partly damaged. | yes |
19,270,434 | Is elevated CC chemokine level in bronchoalveolar lavage fluid predictive of a poor outcome of idiopathic pulmonary fibrosis? | {
"contexts": [
"CC chemokines play important roles in the pathogenesis of interstitial lung diseases. Elevated CC chemokine levels have been observed in bronchoalveolar lavage (BAL) fluid of patients with idiopathic pulmonary fibrosis (IPF).",
"We aimed to examine whether the levels of four CC chemokines, i.... | Elevated levels of CCL2, CCL17 and CCL22 in BAL fluid might be predictive of a poor outcome in patients with IPF. | yes |
19,272,411 | Is mobility of the conserved glycine 155 required for formation of the active plasmodial Pdx1 dodecamer? | {
"contexts": [
"Vitamin B6 synthesis requires a functional Pdx1 assembly that is dodecameric in vivo. We have previously shown that mutation of a catalytic lysine in the plasmodial Pdx1 protein results in a protein that is both inactive and hexameric in vitro.",
"Static and dynamic light scattering, circular... | As the mutated glycine occupies an unrestricted region of the Ramachandran plot the additional stereo-chemical restrictions imposed on alanine residues strongly support our hypothesis that significant structural rearrangement of Pdx1 is required during the transition from hexamer to dodecamer. | yes |
19,249,288 | Does hydrogen-rich saline reduce lung injury induced by intestinal ischemia/reperfusion in rats? | {
"contexts": [
"Hydrogen has been reported to selectively reduce the hydroxyl radical, the most cytotoxic of reactive oxygen species. In this study we investigated the effects of hydrogen-rich saline on the prevention of lung injury induced by intestinal ischemia/reperfusion (I/R) in rats.",
"Male Sprague-Da... | Hydrogen-rich saline attenuates lung injury induced by intestinal I/R. | yes |
19,254,368 | Are cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation involved in Xenopus retinal axon development? | {
"contexts": [
"Translation in axons is required for growth cone chemotropic responses to many guidance cues. Although locally synthesized proteins are beginning to be identified, how specific mRNAs are selected for translation remains unclear. Control of poly(A) tail length by cytoplasmic polyadenylation elemen... | These results indicate that cytoplasmic polyadenylation and CPE-mediated translational regulation are involved in retinal axon development, but that CPEB1 may not be the key regulator of polyadenylation in the developing retina. | yes |
19,270,741 | Does silencing of PINK1 expression affect mitochondrial DNA and oxidative phosphorylation in dopaminergic cells? | {
"contexts": [
"Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD). Impairment of the mitochondrial electron transport chain (ETC) and an increased frequency in deletions of mitochondrial DNA (mtDNA), which encodes some of the subunits of the ETC, have been reported in ... | This report highlights a novel function of PINK1 in mitochondrial biogenesis and a role in maintaining mitochondrial ETC activity. Dysfunction of both has been implicated in sporadic forms of PD suggesting that these may be key pathways in the development of the disease. | yes |
19,265,788 | Does dietary sodium alter the prevalence of electrocardiogram determined left ventricular hypertrophy in hypertension? | {
"contexts": [
"Determination of left ventricular hypertrophy (LVH) via electrocardiogram (ECG) is a known independent risk factor for cardiovascular morbidity and mortality in hypertension (HTN). Dietary sodium and HTN are both associated with unfavorable alterations in left ventricular mass, however, to what e... | Short-term dietary sodium fluctuations can significantly alter overall ECG voltage and the prevalence of ECG-determined LVH in hypertensive individuals. Inclusion of dietary sodium assessment when screening hypertensive subjects for LVH by ECG may improve the consistency of cardiac risk assessment. | yes |
19,265,787 | Does oxidative stress contribute to soluble fms-like tyrosine kinase-1 induced vascular dysfunction in pregnant rats? | {
"contexts": [
"Recent evidence indicates that both increased oxidative stress and an altered balance between pro- and anti-angiogenic factors such as vascular-endothelial growth factor (VEGF) and the soluble VEGF receptor (sFlt-1) contribute to endothelial dysfunction in preeclampsia. We hypothesized that chron... | These data indicate elevated maternal sFlt-1 and decreased VEGF concentrations results in increased oxidative stress that contributes to vascular dysfunction during pregnancy. | yes |
19,260,244 | Does ganglioside GM1 ( porcine ) ameliorate paclitaxel-induced neuropathy in rats? | {
"contexts": [
"Paclitaxel, an anti-neoplastic agent effective against several solid tumors, has several side effects including peripheral neuropathy. So far, there are no effective treatments for this complication. Monosialic acid ganglioside (GM1) has been shown to protect neurons against injuries and degenera... | These data suggest that porcine GM1 may be useful in the prevention and treatment of paclitaxel-induced neuropathy. However the adverse effect of Cremophor EL should be of concern. | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.