pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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22,795,986 | Do the most frequent ED patients carry insurance and a significant burden of disease? | {
"contexts": [
"The objective of this study was to determine factors that impact emergency department (ED) utilization among the most frequent ED users.",
"This prospective observational study consisting of questionnaires was conducted in an urban ED with an annual census of 95000 patients. A convenience sam... | The top 1% of frequent users usually had adequate health insurance and primary care access but were burdened by chronic conditions and frequent hospital admissions. Such patients may require more extensive coordinated medical management to decrease ED utilization. | yes |
22,783,844 | Does practical skills training influence knowledge and attitude of dental students towards emergency medical care? | {
"contexts": [
"Medical emergencies in dental practice are generally perceived as being rare. Nonetheless, recent studies have shown that incidents occur on a regular basis. Therefore, patients have the right to expect necessary skills to manage life-threatening situations from every dentist.",
"To observe s... | The evaluation data clearly show the participants' needs to deal with topics of EMC within the curriculum of dentistry. The proposed course is able to change participants' attitudes towards EMC and its importance for their daily practice. The considerable enhancement of self-confidence in performing EMC-techniques migh... | yes |
22,790,437 | Does the expression of vascular endothelial growth factor in mast cells promote the neovascularisation of human pterygia? | {
"contexts": [
"To analyse the relationship between mast cells and vascularisation in pterygia and to determine whether mast cells play an important role in the vascularisation of pterygia through the secretion of vascular endothelial growth factor (VEGF).",
"Fifty-two pterygia and forty-four normal conjunct... | The results suggest that mast cells have a function in the vascularisation of pterygia through the secretion of VEGF. | yes |
22,772,314 | Is hypoxia induced changes in lung fluid balance in humans associated with beta-2 adrenergic receptor density on lymphocytes? | {
"contexts": [
"Previous studies have demonstrated an important role for beta-2 adrenergic receptors (β(2)AR) in lung fluid clearance. The purpose of this investigation was to examine the relationship between β(2)AR density on lymphocytes and indices of lung water in healthy humans exposed to ≈ 17 h of hypoxia (... | Lung water decreases with 17 h normobaric hypoxia are associated with changes in beta adrenergic receptor density on lymphocytes in healthy adults. | yes |
22,768,249 | Does ectopic expression of MiR-125a inhibit the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF? | {
"contexts": [
"Studies have been shown that miR-125a plays an important role in carcinogenesis, however, the role of miR-125a in hepatocellular carcinoma (HCC) remains elusive.",
"Real time-PCR (qRT-PCR) was performed to test the significance of miR-125a in HCC. Ectopic expression of miR-125a was used to te... | Decreased miR-125a was observed in both HCC tissues and cell lines, and associated with patients' aggressive pathologic features. Up-regulating miR-125a significantly inhibited the malignant phenotypes by repressing the expression of matrix metalloproteinase 11 (MMP11) and vascular endothelial growth factor A (VEGF-A) ... | yes |
22,768,248 | Does sensing of fatty acids for octanoylation of ghrelin involve a gustatory G-protein? | {
"contexts": [
"Ghrelin is an important regulator of energy--and glucose homeostasis. The octanoylation at Ser(3) is essential for ghrelin's biological effects but the mechanisms involved in the octanoylation are unknown. We investigated whether the gustatory G-protein, α-gustducin, and the free fatty acid recep... | This study provides the first evidence that α-gustducin is involved in the octanoylation of ghrelin and shows that the ghrelin cell can sense long- and medium-chain fatty acids directly. GPR120 but not GPR40 may play a role in the lipid sensing cascade of the ghrelin cell. | yes |
22,801,910 | Does [ Investigation of the cases presenting to Dokuz Eylül University Hospital with tick bite ]? | {
"contexts": [
"Determination of the properties of ticks, which are the vectors of many infectious diseases and the patients with tick bites are important for the prevention of these diseases. For tist reason, the purpose of this study is to determine the important properties of the cases presenting with tick bi... | There was no significant difference in removing ticks without damage between the health personnel and the patient or relatives (p=0.133). | yes |
22,782,088 | Does asynchronous thoraco-abdominal motion contribute to decreased 6-minute walk test in patients with COPD? | {
"contexts": [
"Abnormal thoraco-abdominal motion may contribute to exercise limitation in patients with COPD. The current study aimed to assess how the thoraco-abdominal asynchrony in COPD patients correlates with exercise performance during the 6-minute walk test (6MWT).",
"Eighty-eight COPD subjects (40 m... | Thoraco-abdominal asynchrony worsens early during 6MWT in subjects with moderate and severe COPD, and rib cage excursion at 3 min predicts poor walking capability. A pulmonary rehabilitation strategy devised to improve rib cage excursion may help improve exercise tolerance. | yes |
22,783,356 | Does arsenic trioxide induce depolymerization of microtubules in an acute promyelocytic leukemia cell line? | {
"contexts": [
"Arsenic trioxide (As(2)O(3)) is a well-known and effective treatment that can result in clinical remission for patients diagnosed with acute promyelocytic leukemia (APL). The biologic efficacy of As(2)O(3) in APL and solid tumor cells has been explained through its actions on anti-proliferation, ... | The microtubules alterations found with As(2)O(3) treatment suggest that As(2)O(3) increases the depolymerized forms of tubulin in cells and that this is potentially due to arsenite's negative effects on spindle dynamics. | yes |
22,788,240 | Is genetic interaction between NAT2 , GSTM1 , GSTT1 , CYP2E1 , and environmental factors associated with adverse reactions to anti-tuberculosis drugs? | {
"contexts": [
"Adverse drug reactions (ADRs) associated with anti-tuberculosis (anti-TB) drug regimens have considerable impact on anti-TB treatment, potentially leading to unsuccessful outcomes. Nevertheless, the risk factors that play a role in anti-TB drug-induced ADRs are not well established. It is well do... | The study findings provide evidence of the clinical impact of the interaction between pharmacogenetic variability and environmental factors on ADRs induced by anti-TB drug therapy. Predictive pharmacogenetic testing and a comprehensive clinical history would therefore be helpful for identification and careful monitorin... | yes |
22,777,394 | Does low serum neutrophil count predict a positive prostate biopsy? | {
"contexts": [
"Asymptomatic prostatic inflammation may cause increased PSA in some men, leading to unnecessary prostate biopsy. We investigated whether the differential white cell count could predict the result of prostate biopsy.",
"Prostate needle biopsy was carried out in 323 Japanese men with elevated P... | An elevated neutrophil count may be a good indicator of a benign prostate biopsy. Men with a low neutrophil count and an increase of serum PSA should strongly be considered for biopsy. | yes |
22,795,340 | Are markers of endothelial and platelet activation associated with high on-aspirin platelet reactivity in patients with stable coronary artery disease? | {
"contexts": [
"Aspirin inhibits the cyclooxygenase-1 (COX-1) mediated thromboxane A2 synthesis. Despite COX-1 inhibition, in patients with coronary artery disease (CAD), platelets can be activated through other mechanisms, like activation by thrombin.",
"At baseline in this cross-sectional substudy of the A... | The high on-aspirin RPR as defined by PFA100® seems not to be due to increased thrombin activity as evaluated with ETP, sTF, F1+2 or D-dimer. The elevated levels of platelet count, ß-TG, TFPI and especially vWF might be explained by increased endothelial and platelet activation in these patients. | yes |
22,795,349 | Does oxygen-charged HTK-F6H8 emulsion reduce ischemia-reperfusion injury in kidneys from brain-dead pigs? | {
"contexts": [
"Prolonged cold ischemia is frequently associated with a greater risk of delayed graft function and enhanced graft failure. We hypothesized that media, combining a high oxygen-dissolving capacity with specific qualities of organ preservation solutions, would be more efficient in reducing immediate... | The present study has demonstrated that in brain-dead pigs the perfusion of kidneys with oxygen-precharged HTK-perfluorohexyloctane emulsion results in significantly reduced inflammation, hypoxic injury, and apoptosis and cellular integrity and energy content are well maintained. Histologic examination revealed less tu... | yes |
22,771,570 | Does alpha-band power in the left frontal cortex discriminate the execution of fixed stimulus during saccadic eye movement? | {
"contexts": [
"The saccadic paradigm has been used to investigate specific cortical networks involving attention. The behavioral and electrophysiological investigations of the SEM contribute significantly to the understanding of attentive patterns presented of neurological and psychiatric disorders and sports p... | We conclude that absolute alpha power in the left frontal cortex discriminates the execution of the two stimulus presentation patterns during SEM. | yes |
22,776,167 | Is novel procedure , SILSOID colectomy , a bridge between conventional and single-incisional laparoscopic colectomy? | {
"contexts": [
"Laparoscopic colectomy (LC) is a widely accepted treatment for various diseases of the colon. Transumbilical single-incisional laparoscopic surgery (SILS) offers excellent cosmetic results compared with standard multi-port laparoscopic surgery. We describe a new hybrid laparoscopic procedure, SIL... | SILSOID colectomy is safe and feasible and it can be used as an alternative to conventional LC. We consider this procedure to be a bridge between conventional LC and more advanced laparoscopic procedures, such as SILS. | yes |
22,798,110 | Does capsule endoscopy examination identify different leading causes of obscure gastrointestinal bleeding in patients of different ages? | {
"contexts": [
"We aimed to investigate the diagnostic applications of capsule endoscopy examination patients in obscure gastrointestinal bleeding and to analyze the etiology of obscure gastrointestinal bleeding in patients of different ages.",
"A total of 385 patients with obscure gastrointestinal bleeding,... | Capsule endoscopy examination not only shows potential diagnostic value for obscure gastrointestinal bleeding, but it also helps to identify the leading causes of obscure gastrointestinal bleeding in all age groups. | yes |
22,777,768 | Does cD36 repression activate a multicellular stromal program shared by high mammographic density and tumor tissues? | {
"contexts": [
"Although high mammographic density is considered one of the strongest risk factors for invasive breast cancer, the genes involved in modulating this clinical feature are unknown. Tissues of high mammographic density share key histologic features with stromal components within malignant lesions of... | CD36 simultaneously controls adipocyte content and matrix accumulation and is coordinately repressed in multiple cell types within tumor and high mammographic density stroma, suggesting that activation of this stromal program is an early event in tumorigenesis. Levels of CD36 and extent of mammographic density are both... | yes |
22,776,411 | Does corticosteroid treatment inhibit airway hyperresponsiveness and lung injury in a murine model of chemical-induced airway inflammation? | {
"contexts": [
"Exposure to toxic alkylating mustard agents causes both acute and long-term effects to the lungs as indicated by increased number of inflammatory cells in airways, lung edema and lung tissue fibrosis. We have previously demonstrated that treatment with the corticosteroid dexamethasone 1 h after l... | Early treatment with dexamethasone is important in order to reduce the airway hyperresponsiveness and inflammation caused by toxic alkylating mustards such as melphalan. | yes |
22,776,414 | Do sesquiterpene lactones isolated from indigenous Middle Eastern plants inhibit tumor promoter-induced transformation of JB6 cells? | {
"contexts": [
"Sesquiterpene lactones (SL) are plant secondary metabolites that are known for their anti-fungal, anti-bacterial, anti-inflammatory, and anti-tumor properties. Considering that several SL-derived drugs are currently in cancer clinical trials, we have tested two SL molecules, 3-β-methoxy-iso-seco-... | These results highlight the anti-tumor promoting properties of β-tan and Sal A. These SL molecules isolated from two plant species native to the Middle East may provide opportunities for complementary medicine practices. | yes |
22,777,489 | Is time of physical exercise practice after injury in cervical spinal cord-injured men related to the increase in insulin sensitivity? | {
"contexts": [
"Physical exercise has an important role in reducing body fat, risk of chronic disease and systemic inflammation. The aim of this study was to determine serum leptin and insulin concentrations and their relationship to the time of physical exercise after injury in men with cervical spinal cord inj... | Our results suggest that exercise was able to reduce fat mass and increase insulin sensitivity, decreasing plasma levels of risk factors in c-SCI subjects. | yes |
22,767,422 | Do sensory neuro-immune interactions differ between irritable bowel syndrome subtypes? | {
"contexts": [
"The gut is a major site of contact between immune and sensory systems and evidence suggests that patients with irritable bowel syndrome (IBS) have immune dysfunction. Here we show how this dysfunction differs between major IBS subgroups and how immunocytes communicate with sensory nerves.",
"... | Distinct patterns of immune dysfunction and interaction with sensory pathways occur in different patient groups and through different intracellular pathways. Our results indicate IBS patient subgroups would benefit from selective targeting of the immune system. | yes |
22,780,926 | Does [ New compound NL-608 ( a nutlin analog ) induce apoptosis in human breast cancer MCF-7 cells ]? | {
"contexts": [
"To observe the effect of NL-608 (a nutlin analog) on apoptosis induction in human breast cancer MCF-7 cells in vitro, and investigate the relevant molecular mechanism.",
"The effect of NL-608 on proliferation of MCF-7 cells was determined by MTT assay. The apoptosis in MCF-7 cells was determi... | NL-608 induces apoptosis in MCF-7 cells in vitro through inducing caspase 3 activity and death receptor-mediated signal pathway. | yes |
22,785,409 | Does regorafenib induce rapid and reversible changes in plasma nitric oxide and endothelin-1? | {
"contexts": [
"Hypertension is a toxicity of antiangiogenic therapies and a possible biomarker that identifies patients with superior cancer outcomes. Understanding its mechanism will aid in treatment and could lead to the development of other biomarkers for predicting toxicity and anticancer efficacy. Recent e... | These findings indicate that regorafenib induces a coordinated and reversible suppression of NO and stimulation of ET-1. Whether NO and ET-1 might predict therapeutic efficacy in these patients requires further study. | yes |
22,799,339 | Does polysaccharide extracted from Rheum tanguticum prevent irradiation-induced immune damage in mice? | {
"contexts": [
"To investigate the protective effect of purified fraction 1 polysaccharide extracted from Rheum tanguticum RTP1 on irradiation-induced immune damage in mice.",
"Kunming mice were randomly divided into five groups: normal group (NC), irradiation control group (IC), RTP1 low dose (200 mg/kg), m... | RTP1 has an obvious protective effects on damage in γ-ray radiated mice. | yes |
22,773,266 | Does downregulation of MiR-93 expression reduce cell proliferation and clonogenicity of HepG2 cells? | {
"contexts": [
"MiR-93 was observed in various types of cancers. This study is to investigate a role of miR-93 in the carcinogenesis of HCC.",
"The expression of miR-93 in HepG2 cells and prima-ry human hepatocytes (PHHC) was measured by RT-PCR. HepG2 cells were transfected with miR-93 inhibitor or negative ... | Our results reveal an important contribution for miR-93 in hepatocarcinogenesis and suggest a role for TGFBR2 and ITGB8 dysregulation in this process. Thus,the use of synthetic inhibitor of miR-93 may prove to bea promising approach to liver cancer treatment. | yes |
22,801,072 | Does renal function have an effect on cardiovascular mortality in patients with dilated cardiomyopathy? | {
"contexts": [
"Chronic heart failure (CHF) is a major and growing public health problem resulting from the cardiac damage caused by a variety of disease processes. CHF has many comorbid conditions such as hypertension, coronary artery disease, peripheral artery disease and chronic kidney disease (CKD). Some of ... | We have demonstrated that renal function is a prognostic risk marker in patients with ischemic and nonischemic DCM. | yes |
22,785,057 | Is malondialdehyde-modified low-density lipoprotein a useful marker to identify patients with vulnerable plaque? | {
"contexts": [
"The association between elevated malondialdehyde-modified low-density lipoprotein (MDA-LDL) and plaque instability in patients with coronary artery disease (CAD) is suspected but not established. The aim of the present study was therefore to investigate the association between serum MDA-LDL and p... | Using angioscopy and quantitative colorimetry, elevated MDA-LDL was confirmed to be associated with thin-cap atheroma in CAD patients. | yes |
22,804,780 | Is hospital treatment in residential care facilities a viable alternative to hospital admission for selected patients? | {
"contexts": [
"To determine if hospital treatment in residential care facilities, led by a geriatric team, might be a viable alternative to inpatient admission for selected patients.",
"Case series with a new intervention were compared with historical controls receiving the conventional treatment. Treatment... | Hospital treatment in residential care is viable for most patients, including those with dementia and those who need palliative care support. This model of care offers a valuable geriatric service to residents who would prefer to avoid hospital transfers, with no difference in mortality or rehospitalization rates for t... | yes |
22,802,091 | Is physical activity the key determinant of skeletal muscle mitochondrial function in type 2 diabetes? | {
"contexts": [
"Conflicting data exist on mitochondrial function and physical activity in type 2 diabetes mellitus (T2DM) development.",
"The aim was to assess mitochondrial function at different stages during T2DM development in combination with physical exercise in longstanding T2DM patients.",
"We per... | Mitochondrial dysfunction is apparent only in inactive longstanding T2DM patients, which suggests that mitochondrial function and insulin resistance do not depend on each other. Prolonged exercise training can, at least partly, reverse the mitochondrial impairments associated with the longstanding diabetic state. | yes |
22,795,645 | Does oxytocin administration to parent enhance infant physiological and behavioral readiness for social engagement? | {
"contexts": [
"The social milieu provides the context for the organism's survival, endurance, and adaptation. In mammals, social participation originates within the parent-infant bond and is supported by the oxytocin (OT) system, whose functioning is transmitted from parent to child through patterns of parental... | Results are the first to demonstrate that OT administration to one attachment partner can have parallel effects on the other and underscore the role of OT in the cross-generation transmission of human social participation. Findings have translational implications for conditions associated with early risk for social-emo... | yes |
22,782,348 | Is site-specific CpG methylation in the CCAAT/enhancer binding protein delta ( CEBPδ ) CpG island in breast cancer associated with metastatic relapse? | {
"contexts": [
"The CCAAT/enhancer binding protein delta (CEBPδ) is a member of a highly conserved family of basic region leucine zipper transcription factors. It has properties consistent with a tumour suppressor; however, other data suggest that CEBPδ may be involved in the metastatic process.",
"We analys... | CCAAT/enhancer binding protein delta CpG island methylation is associated with metastasis in breast cancer. Detection of methylated CEBPδ genomic DNA may have utility as an epigenetic biomarker of primary breast carcinomas at increased risk of relapse and metastasis. | yes |
22,782,344 | Is a short-term increase in cancer risk associated with daytime napping likely to reflect pre-clinical disease : prospective cohort study? | {
"contexts": [
"Sleep disturbance, a correlate of which is daytime napping, has been hypothesised to be associated with risk of breast and other cancers.",
"We estimated relative risks (RR) of breast and other invasive cancers by the reported frequency of daytime napping in a large prospective cohort of midd... | The effect of pre-clinical disease is a likely explanation for the short-term increased risk of breast and other cancers associated with daytime napping. | yes |
22,782,342 | Do serum markers lactate dehydrogenase and S100B predict independently disease outcome in melanoma patients with distant metastasis? | {
"contexts": [
"Established prognostic factors are of limited value to predict long-term survival and benefit from metastasectomy in advanced melanoma. This study aimed to identify prognostic factors in patients with distant metastasis.",
"We analysed overall survival of 855 institutional melanoma patients w... | The serum markers LDH and S100B were both found to be prognostic factors in melanoma patients with distant metastasis. Furthermore, complete metastasectomy had an independent favourable prognostic impact in particular for the patient subgroup with normal LDH and S100B values. | yes |
22,795,566 | Does cD99 ligation induce intercellular cell adhesion molecule-1 expression and secretion in human gingival fibroblasts? | {
"contexts": [
"To examine CD99 expression and its functional role in ICAM-1 induction in human gingival fibroblasts (HGFs) and human gingival epithelial cells (HGECs) by activating cells with anti-CD99 monoclonal antibody, MT99/3.",
"Engagement of CD99 with agonistic antibodies has been shown to regulate im... | Our study has shown the involvement of CD99 ligation in the up-regulation of ICAM-1 expression and its secretion in gingival fibroblasts, which may be essential for better understanding of the pathogenesis of periodontal disease. | yes |
22,795,567 | Does alendronate enhance osseous healing in a rat calvarial defect model? | {
"contexts": [
"The aim of this study was to evaluate the effect of alendronate on osseous wound healing in an experimental model.",
"Critical size defects were created in calvaria of 40 male Wistar rats. The animals were divided into four groups of 10 animals each: autogenous bone graft group; autogenous bo... | Alendronate enhances the new bone formation by autogenous bone graft in the rat calvarial defect model suggesting that the inhibition of the osteoclastic activity allows an increased rate of bone apposition, which could be applicable to the inflammation-induced destruction of the periodontal tissues during disease. | yes |
22,804,760 | Does voluntary wheel running selectively augment insulin-stimulated vasodilation in arterioles from white skeletal muscle of insulin-resistant rats? | {
"contexts": [
"Exercise (RUN) prevents declines in insulin-mediated vasodilation, an important component of insulin-mediated glucose disposal, in rats prone to obesity and insulin resistance.",
"Determine whether RUN (1) improves insulin-stimulated vasodilation after insulin resistance has been established,... | RUN selectively improved insulin-mediated vasodilation in Gw 2As, in part through attenuated ET-1 sensitivity/production, an adaptation that was independent of changes in adiposity and may contribute to enhanced insulin-stimulated glucose disposal. | yes |
22,770,668 | Do serum bile acids and leptin interact with glucose metabolism in patients with liver cirrhosis? | {
"contexts": [
"We investigated possible involvements of bile acids (BA) and leptin in hepatogenous insulin resistance being present in up to 90% of cirrhotic patients.",
"Blood was analysed in 10 cirrhotic patients (8m/2f, 48 ± 10.4 yrs) and 10 controls (8m/2f, 43 ± 9.3 yrs) after oral nutrition and during ... | Our results suggest a substantial involvement of BA and leptin by improving postprandial glucose tolerance related to liver cirrhosis. | yes |
22,773,318 | Are physical activity/fitness peaks during perimenopause and BMI change patterns associated with baseline activity/fitness in women : a longitudinal study with a median 7-year follow-up? | {
"contexts": [
"To assess the age-associated longitudinal trends in cardiorespiratory fitness (CRF), leisure-time physical activity (PA), and body mass index (BMI) across the lifespan in a cohort of adult women.",
"The sample included 1467 women from the Aerobics Center Longitudinal Study who were 30-79 year... | We concluded that the age-related longitudinal patterns in physical activity and fitness are not linear. Baseline activity and fitness levels are associated with BMI status during adulthood, but do not affect BMI change trajectory. | no |
22,788,775 | Are polymorphisms -1082 G/A and -819 C/T in the interleukin-10 gene associated with gout susceptibility in the Chinese Han male population? | {
"contexts": [
"Gout is caused by monosodium urate crystal-induced inflammation of the joints and periarticular tissues. Interleukin 10 (IL-10) is an important immunoregulatory cytokine, levels of which can be influenced by functional single-nucleotide polymorphisms in the promoter.",
"To investigate the ass... | IL-10 -1082 G/A and -819 C/T polymorphisms may not be associated with susceptibility to gout and thus do not play a major role in the development of gout in the Chinese Han male population. | no |
22,789,824 | Is anxiety associated with striatal dopamine transporter availability in newly diagnosed untreated Parkinson 's disease patients? | {
"contexts": [
"Anxiety is a common non-motor symptom among patients with Parkinson's disease (PD). Although the etiology of anxiety in PD is likely to be multifactorial, a dysfunction in the dopaminergic system might be implicated in its pathogenesis. The aim of our study was to investigate a possible dopaminer... | We reported an association between nigrostriatal DAT availability deficits and anxiety symptoms in newly diagnosed, untreated PD patients. Our results suggest that hypofunction of the nigrostriatal dopaminergic system may represent one of the functional anomalies involved in anxiety in PD from the earliest stages of di... | yes |
22,780,972 | Do [ ICAM-1 469K/E gene polymorphisms increase the risk of gastric dysplasia ]? | {
"contexts": [
"To investigate the influence of ICAM-1 469K/E gene polymorphisms on the risk of atrophic gastritis and dysplasia.",
"The ICAM-1 469K/E gene polymorphisms in a total of 372 subjects were detected by polymerase chain reaction-direct sequencing. All of the subjects were from Linqu County, a high... | ICAM-1 469K/E gene polymorphisms are significantly associated with the risk of gastric low-grade dysplasia, but not related with severe chronic atrophic gastritis in a population with high risk of gastric cancer in Linqu County, Shandong Province, China. | yes |
22,778,512 | Does vitamin C attenuate Chronic Chlorpyrifos-induced Alteration of Neurobehavioral Parameters in Wistar Rats? | {
"contexts": [
"Oxidative stress is one of the molecular mechanisms in chlorpyrifos toxicity. The present study was designed to evaluate the attenuating effect of vitamin C on chlorpyrifos-induced alteration of neurobehavioral performance and the role of muscle acetylchloinesterase (AChE), glycogen and lipoperox... | The study therefore showed that improvement in muscle AChE activity, glycogen concentration and reduced lipoperoxidation by vitamin C may be partly responsible for the mitigation of the chronic CPF-induced sensorimotor performance. | yes |
22,784,503 | Are membrane-bound estrogen receptor-α expression and epidermal growth factor receptor mutation associated with a poor prognosis in lung adenocarcinoma patients? | {
"contexts": [
"The purpose of this study is to clarify the correlations between the expression of membrane-bound estrogen receptor-α (mERα) and epidermal growth factor receptor (EGFR) mutation and clinicopathological factors, especially in relation to the prognosis, in patients with lung adenocarcinoma.",
"... | Presence of mERα expression together with EGFR mutation was found to be an independent prognostic factor for survival in patients with lung adenocarcinoma, suggesting cross-talk between mERα and EGFR mutation. | yes |
22,786,907 | Does mitochondrial superoxide anion overproduction in Tet-mev-1 transgenic mice accelerate age-dependent corneal cell dysfunctions? | {
"contexts": [
"The Tet-mev-1 mouse expressing a mitochondrial complex-II mutated SDHC(V69E) gene controlled by a tetracycline (Tet)-On/Off system can overproduce O(2)(·-) and is a versatile whole-animal model for studying mitochondrial oxidative stress. Here we report a series of age-dependent variations in cor... | These results suggest that mitochondrial oxidative stress with electron transport chain dysfunction can influence pathogenesis and progression of age-related corneal diseases, as well as generalized corneal aging acceleration. | yes |
22,797,397 | Is cyst fluid carcinoembryonic antigen level predictive of invasive cancer in patients with intraductal papillary mucinous neoplasm of the pancreas? | {
"contexts": [
"Cyst fluid CEA concentration>192 ng/mL has proven accurate to differentiate mucinous from non-mucinous pancreatic cystic neoplasms. It is unclear whether the degree of cyst fluid CEA elevation is predictive of malignant behavior in IPMNs.",
"To determine whether elevated cyst fluid CEA concen... | Single center experience, small patient numbers, retrospective data collection. | no |
22,769,858 | Does single-injection femoral nerve block lack preemptive effect on postoperative pain and morphine consumption in total knee arthroplasty? | {
"contexts": [
"Postoperative pain is severe after total knee arthroplasty (TKA). Therefore, femoral nerve block (FNB) is commonly used as an adjuvant to spinal anesthesia for TKA. Some anesthesia providers perform this preoperatively, while others perform it postoperatively. To our knowledge, no study has compa... | Patients who received FNB used for total knee arthroplasty consumed significantly less postoperative morphine and had significant relief of post-TKA pain on postoperative day 1 than those who did not have FNB. However, at follow-up we found no significant differences in these values between those receiving FNB before s... | yes |
22,775,234 | Is childhood physical abuse associated with incident metabolic syndrome in mid-life women? | {
"contexts": [
"Previous research has suggested that childhood emotional abuse, physical abuse, and sexual abuse are associated with an increased risk for ischemic heart disease. Our objective was to examine whether childhood abuse predicted incident metabolic syndrome, a precursor to heart disease, in midlife w... | This is the first study to show that a history of childhood abuse, specifically physical abuse, is related to the development of metabolic syndrome in midlife women. | yes |
22,788,785 | Is the effectiveness of a multidisciplinary QI activity for accidental fall prevention : staff compliance critical? | {
"contexts": [
"Accidental falls among inpatients are a substantial cause of hospital injury. A number of successful experimental studies on fall prevention have shown the importance and efficacy of multifactorial intervention, though success rates vary. However, the importance of staff compliance with these eff... | In our study we observed a substantial decrease in patient fall rates and an increase of staff compliance with a newly implemented falls prevention program. A systematized QI approach that closely involves, encourages, and educates healthcare staff at multiple levels is effective. | yes |
22,795,101 | Is interleukin-1β gene associated with preeclampsia in Taiwanese? | {
"contexts": [
"To identify associations between the interleukin-1β gene and preeclampsia in Taiwanese women.",
"We genotyped Taiwanese population (102 women with preeclampsia and 148 controls) for two polymorphisms of the interleukin-1β gene (promoter region and Exon 5) by using polymerase chain reaction an... | Our data do not support a role of the interleukin-1β gene in the pathogenesis of preeclampsia in Taiwanese women. | no |
22,799,483 | Do toddlers and preschoolers consume more dietary fiber when high-fiber lunch items are served? | {
"contexts": [
"Increasing fiber intake by consuming high fiber foods, which are also high in other nutrients, can improve diet quality and reduce the risk for disease. However, most children do not meet fiber intake recommendations. Food provided at child care centers is a major source of daily nutrients, inclu... | Data indicate that children are accepting of high fiber, novel lunch items, thus indicating that serving high fiber lunch items at child care may increase dietary fiber intake in children. | yes |
22,771,701 | Do salidroside and tyrosol from Rhodiola protect H9c2 cells from ischemia/reperfusion-induced apoptosis? | {
"contexts": [
"Heart disease is the leading cause of death worldwide. Ischemia-reperfusion injury can lead to apoptotic death of heart cells and subsequently heart failure. Rhodiola is an herbal medicine with two main bioactive compounds--salidroside (SAL) and tyrosol (TYR). This study aimed to investigate whet... | The inhibition of the JNK signaling pathway is the key mechanism for the cytoprotective effect of SAL and TYR in IR-induced apoptosis. | yes |
22,777,006 | Does lRP1-dependent endocytic mechanism govern the signaling output of the bmp system in endothelial cells and in angiogenesis? | {
"contexts": [
"Among the extracellular modulators of Bmp (bone morphogenetic protein) signaling, Bmper (Bmp endothelial cell precursor-derived regulator) both enhances and inhibits Bmp signaling. Recently we found that Bmper modulates Bmp4 activity via a concentration-dependent, endocytic trap-and-sink mechanis... | Together, these data reveal a novel role for LRP1 in the regulation of Bmp4 signaling by regulating receptor complex endocytosis. In addition, these data introduce LRP1 as a critical regulator of vascular development. These observations demonstrate Bmper's ability to fine-tune Bmp4 signaling at the single-cell level, u... | yes |
22,777,000 | Do synergistical toll-like receptors activated dendritic cells induce antitumor effects against carcinoembryonic antigen-expressing colon cancer? | {
"contexts": [
"Dendritic cell (DC)-based cancer vaccine represents a promising immunotherapy against cancer. There has been recent evidence which have suggested that toll-like receptor (TLR) ligands may be critical for DC preparation; this was usually omitted in the past. Our study is designed to investigate if... | Our results have proved that combined activation of TLRs can lead to better maturation status of DCs and also induce more effective antitumor immune responses against colon cancer, suggesting this may be a potential strategy to develop more powerful DC cancer vaccines. | yes |
22,801,440 | Is platelet vitamin D receptor reduced in osteoporotic patients? | {
"contexts": [
"It is well known that vitamin D plays an important role in maintaining bone homeostasis and in regulating calcium absorption. The active form of vitamin D interacts with its receptor the VDR that is expressed in multiple tissues and it is involved in platelets (PLTs) function. In the present stud... | The lower VDR expression in osteoporotic could indicate a lower ability to respond to vitamin D, and could be the explanation of the increase in the PTH and decrease in the phosphorus levels in patients with respect to controls. | yes |
22,772,471 | Are two patterns of cerebral metabolite abnormalities detected on proton magnetic resonance spectroscopy in HIV-infected subjects commencing antiretroviral therapy? | {
"contexts": [
"Cerebral function impairment remains problematic in subjects with chronic human immunodeficiency virus (HIV) infection despite effective combination antiretroviral therapy (cART). Using cerebral proton magnetic resonance spectroscopy ((1)H MRS), we aimed to determine if abnormalities could be det... | Two patterns of cerebral metabolite abnormalities were observed in HIV-infected subjects electively commencing cART. Greater inflammatory metabolite ratios (Cho/Cr and MI/Cr) associated with lower markers of peripheral immune markers (CD4+ lymphocyte count) in the FGM and lower neuronal metabolite ratios (NAA/Cho) asso... | yes |
22,768,065 | Does non-invasive mapping of the gastrointestinal microbiota identify children with inflammatory bowel disease? | {
"contexts": [
"Pediatric inflammatory bowel disease (IBD) is challenging to diagnose because of the non-specificity of symptoms; an unequivocal diagnosis can only be made using colonoscopy, which clinicians are reluctant to recommend for children. Diagnosis of pediatric IBD is therefore frequently delayed, lead... | Microbiome-based diagnostics can distinguish pediatric patients with IBD from patients with similar symptoms. Although this test can not replace endoscopy and histological examination as diagnostic tools, classification based on microbial diversity is an effective complementary technique for IBD detection in pediatric ... | yes |
22,783,578 | Is circannual temperature-related variation in hemoglobin A1c unlikely to affect its use as a diagnostic test for type 2 diabetes? | {
"contexts": [
"To evaluate the relationship between temperature and hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) levels in Harbin of China and analyze whether these would affect diagnosis and control of diabetes.",
"Two groups were investigated: 1. Routine patients come from outpatients, 2. Resea... | During the year of this study, there were substantial temperature fluctuations but HbA1c concentration was more stable than FPG in non-diabetic individuals. It is therefore unlikely that temperature-related variation in HbA1c could affect the use of HbA1c as a diagnostic test for type 2 diabetes, but could affect the u... | yes |
22,783,574 | Are cD40 , CD45 CTLA-4 levels elevated in healthy older adults? | {
"contexts": [
"The immune system changes with age. In this study we characterized immune changes by performing immunologic screening profiles on ageing individuals.",
"This study was performed at Akdeniz University, in the Faculty of Medicine, Department of Immunology. Healthy volunteers consisted of a youn... | We found increased expression levels of CD40 and CD45 levels in healthy older (age: 59.42 +/- 5.89) versus younger individuals (age: 30.32 +/- 2.29). CTLA-4 expression levels were also higher in older subjects, with no difference in CD28 expression levels between younger/older individuals. | yes |
22,780,330 | Is financial stress associated with reduced treatment adherence in HIV-infected adults in a resource-rich setting? | {
"contexts": [
"Financial stress has been identified as a barrier to antiretroviral adherence, but only in resource- limited settings. Almost half of HIV-infected Australian adults earn no regular income and, despite highly subsidised antiretroviral therapy and universal health care, 3% of HIV-infected Australia... | These are the first data to show that pharmacy dispensing and clinic travel costs may affect treatment adherence in a resource-rich setting. Patients should be asked if financial stress is limiting their treatment adherence. | yes |
22,775,972 | Does sex differences in the renal vascular response to angiotensin II involve the Mas receptor? | {
"contexts": [
"The renin-angiotensin system (RAS) depressor arm, particularly renal angiotensin type 2 receptor (AT(2) R) and Mas receptor (masR) expression, is enhanced in females, which may contribute to renal and cardiovascular protection. We examined the hypotheses that masR activation increases renal blood... | The impact of the masR on renal haemodynamics appears to be sexually dimorphic, with greater effects in female than male rats. However, the paradoxical effects of dual AT(2) R and masR blockade suggest that a greater understanding of the complex interactions between RAS components is required before the therapeutic opp... | yes |
22,768,254 | Does 14-3-3σ regulate β-catenin-mediated mouse embryonic stem cell proliferation by sequestering GSK-3β? | {
"contexts": [
"Pluripotent embryonic stem cells are considered to be an unlimited cell source for tissue regeneration and cell-based therapy. Investigating the molecular mechanism underlying the regulation of embryonic stem cell expansion is thus important. 14-3-3 proteins are implicated in controlling cell div... | Our findings show for the first time that 14-3-3σ plays an important role in regulating mouse embryonic stem cell proliferation by binding and sequestering phosphorylated GSK-3β and enhancing Wnt-signaled GSK-3β inactivation. 14-3-3σ is a novel target for embryonic stem cell expansion. | yes |
22,775,568 | Are serum biomarkers similar in Churg-Strauss syndrome and hypereosinophilic syndrome? | {
"contexts": [
"Churg-Strauss syndrome (CSS) and hypereosinophilic syndrome (HES) overlap considerably in clinical presentation. A reliable means of distinguishing between these groups of patients is needed, especially in the setting of glucocorticoid therapy.",
"A retrospective chart review of 276 adult sub... | In patients with a history of asthma and sinusitis, distinguishing between ANCA-negative CSS and PDGFR-negative HES is difficult because of significant overlap in clinical presentation and biomarker profiles. | yes |
22,783,321 | Is coalition of DNA polymorphisms of ApoB and ApoAI genes related with coronary artery disease in Kazaks? | {
"contexts": [
"To explore the relationship between polymorphisms of XbaI and MspI loci of apolipoprotein B (ApoB) gene and -75 bp, +83 bp loci of apolipoprotein AI (ApoAI) gene and coronary heart disease (CHD) in Kazaks of Xinjiang Uyghur Autonomous Region, China.",
"These loci were analyzed by PCR-restrict... | Coalition 11 of the 4 loci polymorphisms of the ApoB and ApoAI genes was correlated with CHD in Kazaks, and perhaps the ratio of ApoAI/ApoB was the most diagnostic parameter related with CHD among all lipid parameters. CHD may also be associated with Coalition 5, and, perhaps, Coalition 3 may have been confirmed as a p... | yes |
22,795,062 | Do endogenous angiogenesis inhibitors prevent adaptive capillary growth in left ventricular pressure overload hypertrophy? | {
"contexts": [
"In left ventricular (LV) pressure-overload hypertrophy, lack of adaptive capillary growth contributes to progression to failure. Remodeling of the hypertrophied myocardium requires proteolysis of the extracellular matrix (ECM) carried out by matrix metalloproteinases (MMPs). MMPs, specifically MM... | Up-regulation of angiogenesis inhibitors prevents adaptive capillary growth in pressure-overload hypertrophied myocardium. Therapeutic interventions aimed at inhibition of angiogenesis inhibitors are useful in maintaining capillary density and thereby preventing heart failure. | yes |
22,771,283 | Is autonomic function , as self-reported on the SCOPA-autonomic questionnaire , normal in essential tremor but not in Parkinson 's disease? | {
"contexts": [
"To compare autonomic function of subjects with Parkinson's disease (PD) and essential tremor (ET) relative to controls.",
"It has been reported that patients with PD have autonomic dysfunction while no literature exists regarding autonomic function in ET.",
"Subjects with PD, ET, and cont... | Autonomic scores, particularly gastrointestinal, cardiovascular, urinary, and thermoregulatory were increased in patients with PD, as assessed by SCOPA-Aut. Patients with ET did not exhibit autonomic dysfunction, with the exception of sialorrhea. | yes |
22,789,437 | Does cold-induced stress increase the intensity of Chlamydia genital infection in mice? | {
"contexts": [
"Genital infection by Chlamydia trachomatis (CT) is the most common bacterial sexually transmitted disease worldwide. The infection can cause serious reproductive health complications including pelvic inflammatory disease and infertility. Stress is implicated as a risk factor for various infection... | These results suggest that cold-induced stress induces the production of catecholamines, which may play a critical role in the modulation of the immune system leading to increased susceptibility and greater intensity of Chlamydia genital infection that could promote the development of complications. | yes |
22,781,222 | Does hepatitis C virus viremia increase the incidence of chronic kidney disease in HIV-infected patients? | {
"contexts": [
"Several studies have reported on an association between hepatitis C virus (HCV) antibody status and the development of chronic kidney disease (CKD), but the role of HCV viremia and genotype are not well defined.",
"Patients with at least three serum creatinine measurements after 1 January 200... | Compared with HIV-monoinfected patients, HIV-positive patients with chronic rather than cleared HCV infection were at increased risk of developing CKD, suggesting a contribution from active HCV infection toward the pathogenesis of CKD. | yes |
22,773,559 | Does isoflurane attenuate blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice? | {
"contexts": [
"We examined effects of isoflurane, volatile anesthetics, on blood-brain barrier disruption in the endovascular perforation model of subarachnoid hemorrhage (SAH) in mice.",
"Animals were assigned to sham-operated, SAH+vehicle-air, SAH+1%, or 2% isoflurane groups. Neurobehavioral function, bra... | Two percent isoflurane can suppress post-SAH blood-brain barrier disruption, which may be mediated by sphingosine kinase 1 expression and sphingosine-1-phosphate receptor-1/3 activation. | yes |
22,773,555 | Is warfarin-associated intracerebral hemorrhage inadequately treated at community emergency departments? | {
"contexts": [
"The purpose of this study was to investigate time delays, adherence to guidelines, and their impact on outcomes in patients with warfarin-associated intracerebral hemorrhage transferred from community emergency departments to a comprehensive stroke center.",
"We collected demographic, clinica... | Treatment of warfarin-associated intracerebral hemorrhage in community emergency departments is often suboptimal and does not adhere to published guidelines. Treating coagulopathy aggressively before interhospital transfer may improve outcomes and warrants further investigation. | yes |
22,773,557 | Do patients living in impoverished areas have more severe ischemic strokes? | {
"contexts": [
"Initial stroke severity is one of the strongest predictors of eventual stroke outcome. However, predictors of initial stroke severity have not been well-described within a population. We hypothesized that poorer patients would have a higher initial stroke severity on presentation to medical atten... | We found that increasing community poverty was associated with worse stroke severity at presentation, independent of other known factors associated with stroke outcomes. Socioeconomic status may impact stroke severity via medication compliance, access to care, and cultural factors, or may be a proxy measure for undiagn... | yes |
22,782,244 | Is nitric oxide involved in light-specific responses of tomato during germination under normal and osmotic stress conditions? | {
"contexts": [
"Nitric oxide (NO) is involved in the signalling and regulation of plant growth and development and responses to biotic and abiotic stresses. The photoperiod-sensitive mutant 7B-1 in tomato (Solanum lycopersicum) showing abscisic acid (ABA) overproduction and blue light (BL)-specific tolerance to ... | As well as defective BL signalling, the differential NO-dependent responses of the 7B-1 mutant are probably associated with its high endogenous ABA concentration and related impact on hormonal cross-talk in germinating seeds. These data confirm that light-controlled seed germination and stress responses include NO-depe... | yes |
22,802,943 | Do volatile organic compounds enhance allergic airway inflammation in an experimental mouse model? | {
"contexts": [
"Epidemiological studies suggest an association between exposure to volatile organic compounds (VOCs) and adverse allergic and respiratory symptoms. However, whether VOCs exhibit a causal role as adjuvants in asthma development remains unclear.",
"To investigate the effect of VOC exposure on t... | Our results demonstrate that exposure to VOCs may increase the allergic immune response by interfering with DC function and by inducing oxidative stress and has therefore to be considerate as risk factor for the development of allergic diseases. | yes |
22,772,062 | Does cyclin I correlate with VEGFR-2 and cell proliferation in human epithelial ovarian cancer? | {
"contexts": [
"Ovarian cancer is the most lethal of all gynecologic malignancies. It is characterized by the spread of intraperitoneal tumors, accumulation of ascites, and formation of tumor blood vessels. Cyclin I has been linked with angiogenesis-related proteins, like vascular endothelial growth factor (VEGF... | Our results indicate that elevated expression of cyclin I and VEGFR-2 is likely to provide a proliferative advantage to the EOC cells, and that cyclin I may be linked with angiogenesis in EOC. Higher expression of VEGFR-2 is associated with more advanced disease. Further investigation of cyclin I in ovarian cancer is n... | yes |
22,789,967 | Is hepatoprotective potential of Tecomella undulata stem bark partially due to the presence of betulinic acid? | {
"contexts": [
"Tecomella undulata (TU;` Family Bignoniaceae) is used in Indian Ayurvedic system of medicine for treating various diseases including hepatic ailments. It is also incorporated in various marketed hepatoprotective polyherbal formulations.",
"The present study was aimed at evaluating possible he... | It can be concluded that, hepatoprotective potential of Tecomella undulata stem bark is partially due to the presence of betulinic acid. | yes |
22,790,124 | Is non-alcoholic fatty liver disease an independent predictor for macroangiopathy in Japanese type 2 diabetic patients : a cross-sectional study? | {
"contexts": [
"To clarify the clinical characteristics of type 2 diabetic patients with non-alcoholic fatty liver disease (NAFLD) and to assess whether NAFLD is related to angiopathy.",
"The study included 388 Japanese type 2 diabetic outpatients without viral hepatitis. The main outcome measures were angio... | NAFLD was associated with an increased prevalence of diabetic macroangiopathy and coronary heart disease in elderly patients. In addition, NAFLD is an independent predictor for diabetic macroangiopathy. These findings suggest that type 2 diabetic patients with NAFLD should be considered as a high risk group for develop... | yes |
22,802,086 | Does dexamethasone induce germ cell apoptosis in the human fetal ovary? | {
"contexts": [
"The 21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia. Pregnant women presenting a risk of genetic transmission may be treated with synthetic glucocorticoids such as dexamethasone (DEX) to prevent female fetus virilization.",
"The aim of this study was to as... | We have demonstrated for the first time that in vitro exposure to high doses of DEX impairs human fetal oogenesis through an increase in apoptosis. These data are of high importance, and additional epidemiological studies are required to investigate the female fertility of those women who have been exposed to DEX durin... | yes |
22,795,997 | Does duration of well-controlled core temperature correlate with neurological outcome in patients with post-cardiac arrest syndrome? | {
"contexts": [
"Detailed procedures for optimal therapeutic hypothermia (TH) have yet to be established. We examined how duration of well-controlled core temperature within the first 24 hours after cardiac arrests (CA) correlated with neurological outcomes of successfully resuscitated out-of-hospital CA (OHCA) p... | TH maintained at target temperature of 33 °C ± 1 °C over 18 hours independently correlated with favorable neurological outcome. Therefore, stable core temperature control may improve neurological outcome of successfully resuscitated OHCA. | yes |
22,797,704 | Is nELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells mediated via c-Jun N-terminal kinase pathway activation? | {
"contexts": [
"NELL-1 is a novel osteoinductive growth factor that has shown promising results for the regeneration of bone. Moreover, NELL-1 has been used successfully in bone regeneration in the axial, appendicular and calvarial skeleton of both small and large animal models. Despite increasing evidence of NE... | Thus, activation of the JNK pathway is necessary to mediate terminal osteogenic differentiation of Saos-2 osteosarcoma cells by rhNELL-1. Future studies will extend these in vitro mechanisms to the in vivo effects of NELL-1 in dealing with orthopaedic defects caused by skeletal malignancies or other aetiologies. | yes |
22,800,477 | Is [ CD5 expression an adverse prognostic factor in diffuse large B-cell lymphoma ]? | {
"contexts": [
"To analyze CD5 expression in diffuse large B cell lymphoma (DLBCL) and to explore its relationship with the clinicopathological characteristics.",
"The clinical data from 160 DLBCL patients who were treated in First Bethune Hospital of Jilin University from January 2001 to December 2010 were ... | CD5 expression is an adverse prognostic factor in DLBCL and it has more prognostic value in the condition of low IPI (0 ∼ 2). | yes |
22,801,586 | Does the UCSD shortness of breath questionnaire have longitudinal construct validity in idiopathic pulmonary fibrosis? | {
"contexts": [
"Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease that often causes disabling dyspnea. In IPF and other lung diseases, patient-reported outcomes (PROs)-questionnaires designed to gather information from the patient's perspective-can determine whether therapies affect ... | These results support the validity of the UCSD to assess change in dyspnea over time in patients with IPF. | yes |
22,800,960 | Does brain-derived neurotrophic factor enhance the contraction of intestinal muscle strips induced by SP and CGRP in mice? | {
"contexts": [
"Brain-derived neurotrophic factor (BDNF) has been found in the intestinal tract of a variety of species. Its effects on visceral hyperalgesia have been examined to some degree, but limited studies have focused on gut motility. The aim of the present study was to investigate the effects of BDNF on... | These data clarified the excitatory effects of SP, ACh and bilateral effects of CGRP on gut motility of mice and confirmed an essential role of BDNF on accelerating gut motility by enhancing the excitatory effects of SP/CGRP. | yes |
22,781,576 | Do [ Protective effects of N-acetylcysteine on cochlear damage occur in guinea pigs exposed to irradiation ]? | {
"contexts": [
"To explore the protective effects of N-acetylcysteine (NAC) on cochlear damage occurring in irradiated guinea pigs.",
"Seventy-two guinea pigs were randomly divided into 4 groups (n = 18 each). Control group received neither NAC nor irradiation, irradiation group received total cranium irradi... | MDA and SOD may be involved in the pathogenesis of cochlear cell damage. And NAC protects the irradiated cochlear cell. | yes |
22,768,080 | Does metadherin contribute to the pathogenesis of diffuse large B-cell lymphoma? | {
"contexts": [
"Metadherin (MTDH) has been demonstrated as a potentially crucial mediator of various types of human malignancies. However, the expression and role of MTDH in diffuse large-B-cell lymphoma (DLBCL) have not been reported yet. This study aimed to illuminate the role of MTDH in the pathogenesis of DL... | Our results suggest that MTDH contributes to the pathogenesis of DLBCL mediated by activation of Wnt/β-catenin pathway. This novel study may contribute to further investigation on the useful biomarkers and potential therapeutic target in the DLBCL patients. | yes |
22,766,707 | Do adipose-derived mesenchymal stem cells ameliorate STZ-induced pancreas damage in type 1 diabetes? | {
"contexts": [
"To investigate the possibility of adipose-derived mesenchymal stem cells (ADSC) in the treatment of type 1 diabetes (T1D).",
"ADSC were isolated from the adipotic tissue of abdomen in Sprague-Dawley rats (4-6 week-old,female) and expanded in vitro. Cells were then identified by testing their ... | Intravenuously injected ADSC can prevent STZ induced β-cell destruction and decrease blood glucose level. | yes |
22,766,703 | Do thawed autologous peripheral blood stem cells require modified quantification methods for hematopoietic progenitor cell evaluation? | {
"contexts": [
"The aim of this study was first, to analyze the post-thaw progenitor assays usually performed on peripheral blood stem cell autografts and second, to achieve standardization with improved flow cytometric and CFU-GM assays.",
"In the first part of the study (n=79), recovery and Intraclass Corr... | Avoiding cell washing in the flow cytometric method limited the overestimate of the CD34 percentage. Plating 500 thawed CD34 improved reliability of the results and allowed a better standardization of the assay. | yes |
22,789,109 | Does polyvinyl alcohol hydrogel decrease formation of adhesions in a rat model of peritonitis? | {
"contexts": [
"Adhesion formation after surgery for peritonitis-related conditions, with such associated complications as intestinal obstruction, pain, and infertility, remains an important problem. Applying a liquid barrier intra-peritoneally might reduce initial adhesion formation.",
"A combination of the... | In this experiment, PVA/CMC hydrogel reduced the amount of adhesions to the SWD and between viscera significantly with equal risk of abscess formation. | yes |
22,771,736 | Is aging associated with a diminished axon reflex response to local heating on the gaiter skin area? | {
"contexts": [
"Elderly patients are susceptible to skin ulcerations on the supramedial malleolar area of the leg. Our aim was, using local thermal hyperemia, to study microvascular function on the gaiter skin area of elderly, but otherwise healthy volunteers, because abnormal microvascular reactivity could cont... | Physiological aging is associated with an altered initial axon reflex response to local heating in the supramedial malleolar skin. Further work is required to determine whether these changes are more pronounced in frail and dependent groups and whether they could explain the higher incidence of skin ulcerations in the ... | yes |
22,776,995 | Is a polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH ( FAAH C385A ) associated with emotional-motivational reactivity? | {
"contexts": [
"The endocannabinoid (eCB) system is implicated in several psychiatric disorders. Investigating emotional-motivational dysfunctions as underlying mechanisms, a study in humans revealed that in the C385A polymorphism of the fatty acid amide hydrolase (FAAH), the degrading enzyme of the eCB anandami... | Our findings emphasize the bidirectionality and thorough examination of the eCB system's impact on emotional reactivity as a central endophenotype underlying various psychiatric disorders. | yes |
22,801,452 | Is knee extensor torque of men with early degrees of osteoarthritis associated with pain , stiffness and function? | {
"contexts": [
"Osteoarthritis (OA) is a chronic-degenerative disease. The knee is the most commonly affected joint and the symptoms are generally attributed to quadriceps muscle weakness. However, few studies have evaluated this relationship in a population with early stages of knee OA.",
"To investigate wh... | The concentric and eccentric knee extensor torque is significantly correlated with self-report symptoms of patients in initial stages of knee OA. Therefore, the strengthening of the quadriceps muscles, through concentric and eccentric exercise is indicated for these patients in order to minimize these symptoms. | yes |
22,767,438 | Is upregulation of miR-650 correlated with down-regulation of ING4 and progression of hepatocellular carcinoma? | {
"contexts": [
"In the last decade, studies in hepatocellular carcinoma (HCC) demonstrate dysregulation of miRNAs expression. For instance, miR-650 has been implicated in gastric and colorectal cancer tumorigenicity; however, the role of miR-650 remains unknown in HCC.",
"In this study, we performed a compre... | These data suggested that miR-650 is correlated with the pathogenesis of HCC and is involved in the HCC tumorigenesis process by inhibiting the expression of ING4. | yes |
22,792,183 | Are hCV genotypes differently prone to the development of resistance to linear and macrocyclic protease inhibitors? | {
"contexts": [
"Because of the extreme genetic variability of hepatitis C virus (HCV), we analyzed whether specific HCV-genotypes are differently prone to develop resistance to linear and macrocyclic protease-inhibitors (PIs).",
"The study includes 1568 NS3-protease sequences, isolated from PI-naive patients... | The high degree of HCV genetic variability makes HCV-genotypes, and even subtypes, differently prone to the development of PIs resistance-mutations. Overall, this can account for different responsiveness of HCV-genotypes to PIs, with important clinical implications in tailoring individualized and appropriate regimens. | yes |
22,797,609 | Does pre-existing arteriosclerotic intimal thickening in living-donor kidneys reflect allograft function? | {
"contexts": [
"Donor shortage is a serious problem worldwide and it is now debated whether kidneys from marginal donors are suitable for renal transplantation. Recent studies have shown that the findings of preimplantation kidney biopsy are useful to evaluate vasculopathy in the donated kidney, and may predict ... | The present study demonstrated that mild arteriosclerotic vasculopathy in the donated kidney is an important pathological factor that reflects future impaired function of renal allografts from marginal donors. | yes |
22,802,811 | Is computed tomography perfusion examination helpful in evaluating the extent of oropharyngeal and oral cavity cancer? | {
"contexts": [
"Squamous cell cancer (SCC) of the head and neck, like other malignancies, should be reported with regard to TNM classification and treated accordingly. Sole anatomic imaging has its drawbacks, as early lesion detection often remains challenging, non-neoplastic processes can mimic malignancies and... | CTP shows promise in distinguishing benign and malignant processes, primarily by means of BF, BV and PS. | yes |
22,786,471 | Do dexmedetomidine and clonidine inhibit ventricular tachyarrhythmias in a rabbit model of acquired long QT syndrome? | {
"contexts": [
"Agents with α-2 adrenoreceptor (AR) agonistic action have reportedly suppressed tachyarrhythmias.",
" We hypothesized that α-2 AR agonists would have an inhibitory effect on abnormal repolarization-related ventricular tachyarrhythmias (VTs). To test this hypothesis, the effects of 2 clinicall... | Agents with α-2 AR agonistic action have an inhibitory effect on VTs in a rabbit model of long QT syndrome. Alpha-2 AR agonists, especially dexmedetomidine, may be a therapeutic choice for abnormal repolarization-related VTs that are resistant to conventional treatment. | yes |
22,766,560 | Does antitachycardia pacing reduce appropriate and inappropriate shocks in children and congenital heart disease patients? | {
"contexts": [
"Antitachycardia pacing (ATP) can reduce implantable cardioverter-defibrillator shocks, but its use in children and patients with congenital heart disease (CHD) is not well described.",
"To review the efficacy of ATP in children and patients with CHD.",
"We reviewed implantable cardioverte... | ATP is highly efficacious for VT in children and patients with CHD. In addition to reducing appropriate shocks, inappropriate shocks due to sinus or supraventricular tachycardia can be significantly reduced with ATP. | yes |
22,770,253 | Does [ Inconsistency of the Epworth sleepiness scale result with the polysomnography findings in patients with sleep-disordered breathing ]? | {
"contexts": [
"This study aims to investigate the consistency of Epworth sleepiness scale (ESS) results and polysomnography (PSG) findings in the patients with sleep-disordered breathing (SDB).",
"A total of 109 patients (68 males, 41 females; mean age 48.6 years; range 20 to 77 years) who were admitted wit... | The responses to the questions in the ESS may vary from individual to individual, depending on the socio-cultural and economic status. We believe, therefore, that a new Turkey-based questionnaire considering the lifestyle of our population would offer more useful information about sleep disordered breathing. | yes |
22,789,011 | Does human pituitary tumor-transforming gene 1 overexpression reinforce oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells? | {
"contexts": [
"hPTTG1 (human pituitary tumor-transforming gene 1) is an oncogene overexpressed in breast cancer and several other types of cancer. Increased hPTTG1 expression has been shown to be associated with poor patient outcomes in breast cancer. Although hPTTG1 overexpression plays important roles in prom... | Our findings provide novel molecular insights into hPTTG1-induced senescence and identify a novel mechanism by which hPTTG1 promotes metastasis by regulating the senescence-associated microenvironment. | yes |
22,789,015 | Does p2X7 signaling promote microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand? | {
"contexts": [
"The cerebral microvascular occlusion elicits microvascular injury which mimics the different degrees of stroke severity observed in patients, but the mechanisms underlying these embolic injuries are far from understood. The Fas ligand (FasL)-Fas system has been implicated in a number of pathogeni... | FasL functions as a key component of an immunoreactive response loop by recruiting microglia to the lesion sites through a P2X(7)-dependent mechanism. The specific modulation of P2X(7)/FasL signaling and aberrant microglial activation could provide therapeutic benefits in acute and subacute phase of cerebral microembol... | yes |
22,772,755 | Does enhancement of 26S proteasome functionality connect oxidative stress and vascular endothelial inflammatory response in diabetes mellitus? | {
"contexts": [
"Although the connection of oxidative stress and inflammation has been long recognized in diabetes mellitus, the underlying mechanisms are not fully elucidated. This study defined the role of 26S proteasomes in promoting vascular inflammatory response in early diabetes mellitus.",
"The 26S pro... | Early hyperglycemia enhances 26S proteasome functionality, not autophagy or unfolded protein response, through peroxynitrite/superoxide-mediated PA700-dependent proteasomal activation, which elevates NF- ĸB-mediated endothelial inflammatory response in early diabetes mellitus. | yes |
22,789,426 | Does adenosine facilitate dormant conduction across cavotricuspid isthmus following catheter ablation? | {
"contexts": [
"Recurrence of trans-isthmus conduction following catheter ablation of common right atrial flutter (AFL) has been reported to be as high as 15%-31% at 3 months with invasive follow-up. Intravenous adenosine has previously been shown to facilitate acute, transient reconnection of pulmonary veins fo... | Adenosine infusion can facilitate dormant conduction across CTI following catheter ablation. Persistent BDB can be achieved with additional ablation. Adenosine challenge with additional ablation may improve long-term clinical outcome. | yes |
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