pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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22,785,107 | Do neutrophil serine proteases mediate inflammatory cell recruitment by glomerular endothelium and progression towards dysfunction? | {
"contexts": [
"Neutrophil recruitment into glomerular tissues and reduced capillary wall integrity has been implicated in the development of vasculitic glomerulonephritis (VGN). This study investigated the stages and mechanisms through which neutrophil serine proteases (SPs), proteinase 3 (PR3) or elastase cont... | Neutrophil SPs induce a pro-adhesive phenotype in glomerular endothelium primarily by inducing neutrophil and platelet adhesion that transits to dysfunction after high/prolonged exposures. Dysregulated release of these enzymes within glomeruli may contribute to injury during diseases such as VGN. | yes |
22,781,909 | Does histological loss of pancreatic exocrine cells correlate with pancreatic exocrine function after pancreatic surgery? | {
"contexts": [
"The aim of this study was to investigate the relationship between histological findings of the pancreatic stump and postoperative pancreatic exocrine function.",
"One hundred ten patients including 80 patients undergoing pancreatoduodenectomy (PD) and 30 patients undergoing distal pancreatect... | Pancreatoduodenectomy induced pancreatic exocrine insufficiency more frequently than DP. Histological loss of acinar cells in the pancreatic stump was strongly correlated with postoperative pancreatic exocrine function. | yes |
22,776,365 | Does intraoperative colonoscopy facilitate safe dissection of the rectal pouch in a case of male imperforate anus? | {
"contexts": [
"In an imperforate anus, colostography often fails to identify recto-urethral fistula (RUF). Thus, surgeons must always assume an RUF is present, despite colostography findings, and dissect the distal rectal pouch (RP) with caution. We report the usefulness of intraoperative colonoscopy (IOC) for ... | IOC can be used to exclude RUF and facilitate safe dissection of the RP in imperforate anus. | yes |
22,768,267 | Are serum uric acid levels associated with polymorphism in the SAA1 gene in Chinese subjects? | {
"contexts": [
"Serum uric acid (SUA) is a cardiovascular risk marker associated with inflammation. The serum amyloid A protein (SAA) is an inflammatory factor and is associated with cardiovascular disease (CVD). However, the relationship between genetic polymorphisms of SAA and SUA levels has not been studied. ... | The rs12218 SNP in the SAA1 gene was associated with SUA levels in Chinese subjects, indicating that carriers of the T allele of rs12218 have a high risk of hyperuricemia. | yes |
22,771,307 | Are viral kinetics associated with changes in cytokines and chemokines in serum and target organs of SSM-CVB3-infected macaques? | {
"contexts": [
"To determine the relationship between viral kinetics and the expression patterns for different cytokines and chemokines in the serum and organs of coxsackievirus B3 (SSM-CVB3)-infected macaques over the course of infection.",
"SSM-CVB3 levels in serum and organs were measured using the Spearm... | The results indicate that patterns of cytokine and chemokine response are associated with viral kinetics in the serum and target organs of SSM-CVB3-infected macaques, suggesting that the changes in cytokines and chemokines could help further our understanding of the progress of CVB3 infections in clinical settings. | yes |
22,792,140 | Are wealth status , mid upper arm circumference ( MUAC ) and antenatal care ( ANC ) determinants for low birth weight in Kersa , Ethiopia? | {
"contexts": [
"Low Birth Weight (LBW) is one of the major risk factor for death in early life. However, little is known about predictors of LBW in sub-Saharan Africa. Therefore, the aim of this study was to measure the incidence and determinants of LBW in a rural population of Ethiopia.",
"An observational ... | The incidence of LBW was high in Kersa. Babies born to women who were poor, undernourished, experienced physical violence during pregnancy and who had poor access to health services were more likely to be LBW in this part of the country. In this largely poor community where ANC coverage is low, to reduce the incidence ... | yes |
22,792,001 | Do patients with persistent pain after breast cancer surgery show both delayed and enhanced cortical stimulus processing? | {
"contexts": [
"Women who undergo breast cancer surgery have a high risk of developing persistent pain. We investigated brain processing of painful stimuli using electroencephalograms (EEG) to identify event-related potentials (ERPs) in patients with persistent pain after breast cancer treatment.",
"Nineteen... | These results show that treatment and persistent pain have opposite effects on cortical responsiveness. | yes |
22,794,168 | Is array-based comparative genomic hybridization more informative than conventional karyotyping and fluorescence in situ hybridization in the analysis of first-trimester spontaneous abortion? | {
"contexts": [
"Array-based comparative genomic hybridization (aCGH) is a new technique for detecting submicroscopic deletions and duplications, and can overcome many of the limitations associated with classic cytogenetic analysis. However, its clinical use in spontaneous abortion needs comprehensive evaluation.... | aCGH analysis circumvents many limitations in traditional karyotyping or FISH. The accuracy and efficiency of aCGH in spontaneous abortions highlights its clinical usefulness for the future. As aborted tissues have the potential to be contaminated with maternal cells, the threshold value of detection in aCGH should be ... | yes |
22,773,065 | Do hip- and knee-strength assessments using a hand-held dynamometer with external belt-fixation are inter-tester reliable? | {
"contexts": [
"In football, ice-hockey, and track and field, injuries have been predicted, and hip- and knee-strength deficits quantified using hand-held dynamometry (HHD). However, systematic bias exists when testers of different sex and strength perform the measurements. Belt-fixation of the dynamometer may r... | The present study shows that isometric hip- and knee-strength measurements have acceptable inter-tester reliability at the group level, when testing strong individuals, using HHD with belt-fixation. This procedure is therefore perfectly suited for the evaluation and monitoring of strong athletes with hip, groin and ham... | yes |
22,798,388 | Do circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction? | {
"contexts": [
"Elevated serum C-reactive protein (CRP) following myocardial infarction (MI) is associated with poor outcomes. Although animal studies have indicated a direct pathogenic role of CRP, the mechanism underlying this remains elusive. Dissociation of pentameric CRP (pCRP) into pro-inflammatory monomer... | Circulating MPs can convert pCRP to pro-inflammatory mCRP in patients following MI, demonstrating for the first time mCRP generation in vivo and its detection in circulating blood. MPs can bind to cell membranes and transfer mCRP to the cell surface, suggesting a possible mCRP transport/delivery role of MPs in the circ... | yes |
22,781,788 | Do hot flushes and night sweats differ in associations with cardiovascular markers in healthy early postmenopausal women? | {
"contexts": [
"The aim of this study was to evaluate the associations between vasomotor symptoms ([VMS] hot flushes or flashes and night sweats) and markers of cardiovascular risk.",
"Healthy postmenopausal women in a randomized controlled trial of progesterone for VMS recorded VMS frequency in the Daily Me... | Hot flushes, but not night sweats, were associated with lower cardiovascular risk factors in these healthy postmenopausal women. Future research should differentiate night sweats from hot flushes. | yes |
22,773,583 | Does immediately preoperative use of biological therapy influence liver regeneration after large resection -- porcine experimental model with monoclonal antibody against epidermal growth factor? | {
"contexts": [
"The aim of this work was to study the influence of isolated biological therapy administered immediately before extended liver resection on liver function and regenerative capacity of future liver remnant (FLR) in a large-animal experiment.",
"Nineteen piglets were included in this study (10 i... | The achieved results of comparable liver regeneration in both the experimental and control groups confirms the use of biological treatment with cetuximab in the pre-operative period for minimizing the recovery period. | no |
22,780,999 | Does heat-processed ginseng enhance the cognitive function in patients with moderately severe Alzheimer 's disease? | {
"contexts": [
"Ginseng has been reported to improve cognitive function in animals and in healthy and cognitively impaired individuals. In this study, we investigated the efficacy of a heat-processed form of ginseng that contains more potent ginsenosides than raw ginseng in the treatment of cognitive impairment ... | These results demonstrate the potential efficacy of a heat-processed form of ginseng on cognitive function and behavioral symptoms in patients with moderately severe AD. | yes |
22,770,501 | Does oxidation of the yeast mitochondrial thioredoxin promote cell death? | {
"contexts": [
"Yeast, like other eukaryotes, contains a complete mitochondrial thioredoxin system comprising a thioredoxin (Trx3) and a thioredoxin reductase (Trr2). Mitochondria are a main source of reactive oxygen species (ROS) in eukaryotic organisms, and this study investigates the role of Trx3 in regulatin... | Mitochondrial Prx1 functions as a redox signaling molecule that oxidizes Trx3 and promotes apoptosis. This would mean that under conditions where Prx1 cannot detoxify mitochondrial ROS, it induces cell death to remove the affected cells. | yes |
22,767,074 | Do a scoping study of one-to-one peer mentorship interventions and recommendations for application with Veterans with postdeployment syndrome? | {
"contexts": [
"We employ the term postdeployment syndrome (PDS) to characterize the combinations of physical, psychological, and social difficulties frequently encountered by Veterans returning from combat.",
"To conduct a scoping review to identify and describe one-to-one peer mentorship (PM) interventions... | This review supports the application in this population and proposes next steps for the development and systematic evaluation of PM interventions. | yes |
22,792,368 | Does hilar GABAergic interneuron activity control spatial learning and memory retrieval? | {
"contexts": [
"Although extensive research has demonstrated the importance of excitatory granule neurons in the dentate gyrus of the hippocampus in normal learning and memory and in the pathogenesis of amnesia in Alzheimer's disease (AD), the role of hilar GABAergic inhibitory interneurons, which control the gr... | Our findings establish a critical role for hilar GABAergic interneuron activity in controlling spatial learning and memory retrieval and provide evidence for the potential contribution of GABAergic interneuron impairment to the pathogenesis of amnesia in AD. | yes |
22,792,364 | Is placental size associated with mental health in children and adolescents? | {
"contexts": [
"The role of the placenta in fetal programming has been recognized as a highly significant, yet often neglected area of study. We investigated placental size in relation to psychopathology, in particular attention deficit hyperactivity disorder (ADHD) symptoms, in children at 8 years of age, and l... | Compensatory placental growth may occur in response to prenatal insults. Such overgrowth may affect fetal development, including brain development, and ultimately contribute to psychopathology. | yes |
22,773,547 | Does a novel mouse model of veno-occlusive disease provide strategies to prevent thioguanine-induced hepatic toxicity? | {
"contexts": [
"The anti-leukemic drugs, azathioprine and 6-mercaptopurine (6MP), are important in the treatment of inflammatory bowel disease but an alternative faster-acting, less-allergenic thiopurine, 6-thioguanine (6TG), can cause hepatic veno-occlusive disease/sinusoidal obstructive syndrome (SOS). Underst... | This novel model provides clinically relevant insights into how 6TG induces SOS, and how this dangerous adverse drug reaction may be avoided by either inhibition of endothelial activation or simple changes to dosing regimens of 6TG, while still being effective treatment for colitis. | yes |
22,781,548 | Is static hyperinflation associated with decreased peak exercise performance in children with cystic fibrosis? | {
"contexts": [
"We evaluated the exercise capacity of children with cystic fibrosis to determine whether ventilatory limitation associated with static hyperinflation is related with decreased exercise capacity, thus predisposing these children to arterial hypoxemia during progressive exercise.",
"Thirty-seve... | In children with cystic fibrosis, static hyperinflation and ventilatory limitation are associated with decrease in exercise performance, oxygen saturation, and P(aO(2)) during maximum cardiopulmonary exercise testing. All children with cystic fibrosis who exhibit static hyperinflation and ventilatory limitation may req... | yes |
22,780,947 | Are macular lutein and zeaxanthin related to brain lutein and zeaxanthin in primates? | {
"contexts": [
"Xanthophyll pigments lutein and zeaxanthin cross the blood-retina barrier to preferentially accumulate in the macular region of the neural retina. There they form macular pigment, protecting the retina from blue light damage and oxidative stress. Lutein and zeaxanthin also accumulate in brain ti... | An integrated measure of total macular pigment optical density, which can be measured non-invasively, has the potential to be used as a biomarker to assess brain lutein and zeaxanthin status. | yes |
22,788,692 | Do colon cancer associated genes exhibit signatures of positive selection at functionally significant positions? | {
"contexts": [
"Cancer, much like most human disease, is routinely studied by utilizing model organisms. Of these model organisms, mice are often dominant. However, our assumptions of functional equivalence fail to consider the opportunity for divergence conferred by ~180 Million Years (MY) of independent evolut... | Identifying positive selection in the Primate, Hominidae, Muridae and Murinae lineages suggests an ancestral functional shift in these genes between the rodent and primate lineages. Analyses such as this, combining evolutionary theory and predictions - along with medically relevant data, can thus provide us with import... | yes |
22,772,092 | Does inhibition of the placental growth factor decrease burden of cholangiocarcinoma and hepatocellular carcinoma in a transgenic mouse model? | {
"contexts": [
"Hepatocellular carcinoma and cholangiocarcinoma form the majority of primary hepatic tumours and are the third most common cause of cancer-related deaths. These liver tumours rapidly outgrow their vascular supply and become hypoxic, resulting in the production of hypoxia inducible factors and tri... | The use of monoclonal antibodies targeting PlGF could thus offer a potential systemic treatment for patients who suffer from primary liver tumours. | yes |
22,783,282 | Is medical comorbidities at admission predictive for 30-day in-hospital mortality in patients with acute myocardial infarction : analysis of 5161 cases? | {
"contexts": [
"The present study investigated the prognostic value of medical comorbidities at admission for 30-day in-hospital mortality in patients with acute myocardial infarction (AMI).",
"A total of 5161 patients with AMI were admitted in Chinese PLA General Hospital between January 1, 1993 and Decembe... | Medical comorbidities were frequently found in patients with AMI. AMI patients with more comorbidities had a higher 30-day in-hospital mortality might be predictive of early poor outcome in patients with AMI. | yes |
22,804,815 | Is tumour-free distance from serosa a better prognostic indicator than depth of invasion and percentage myometrial invasion in endometrioid endometrial cancer? | {
"contexts": [
"To evaluate the prognostic performance of tumour-free distance (TFD) compared with depth of invasion (DOI) and percentage of myometrial invasion (MI).",
"Retrospective cohort study.",
"Regional gynaecological oncology centre.",
"All women identified with stage I-III endometrioid endom... | The TFD measure may be a more accurate method of representing myometrial invasion in the staging for endometrial cancer. | yes |
22,801,011 | Do intramucosal bacterial microcolonies exist in chronic rhinosinusitis without inducing a local immune response? | {
"contexts": [
"Although chronic rhinosinusitis (CRS) causes very significant morbidity, much about its pathogenesis remains uncertain. Recent studies have identified polymicrobial biofilms on the surface of sinus mucosa and Staphylococcus aureus within the sinus mucosa of patients with CRS, both with and witho... | Bacterial microcolonies are prevalent within paranasal sinus mucosa and are commonly S. aureus. These microcolonies do not provoke immune detection and may represent a phenotype that actively evades host immunity. This may underpin the recalcitrance of CRS to antibiotic therapy. These findings challenge classic views ... | yes |
22,792,416 | Are oxidative damage , inflammation , and Toll-like receptor 4 pathway increased in preeclamptic patients : a case-control study? | {
"contexts": [
"There was no direct correlation between plasma and placental oxidative damage parameters and inflammation and evidence of TLR4 pathway activation in the placenta in preeclamptic (PE) patients.",
"33 PE patients and 33 normotensive pregnant women were included. The maternal section of the plac... | The TLR4-NF-kB pathway is upregulated in PE, probably generating local and systemic inflammatory response that is followed by local and systemic oxidative damage. | yes |
22,791,141 | Does reduced-dose docetaxel for castration-resistant prostate cancer have no inferior impact on overall survival in Japanese patients? | {
"contexts": [
"In clinical practice, an adapted regimen with dose reduction is applied to castration-resistant prostate cancer (CRPC) treated with docetaxel because of its toxicity. However, there are few reports on the impact of dose reduction on survival.",
"Fifty-seven patients with CRPC treated with fir... | A reduced-dose regimen of docetaxel has no inferior impact on OS. Further studies on the optimal dose of docetaxel for Japanese patients are required. | yes |
22,767,698 | Does provision of a soy-based intravenous lipid emulsion at 1 g/kg/d prevent cholestasis in neonates? | {
"contexts": [
"One of the most common and severe complications of long-term parenteral nutrition (PN) is PN-associated cholestasis. The soybean oil-based lipid emulsion administered with PN has been associated with cholestasis, leading to an interest in lipid reduction strategies. The purpose of this study was ... | Lipid reduction to 1 g/kg/d does not prevent or delay the onset of cholestasis in neonates. | no |
22,797,246 | Does activation of transforming growth factor-β/Smad signaling reduce aggregate formation of mislocalized TAR DNA-binding protein-43? | {
"contexts": [
"TAR DNA-binding protein of 43 kDa (TDP-43) is naturally located in the nucleus and has been identified as the major component of cytoplasmic ubiquitinated inclusions in patients with amyotrophic lateral sclerosis (ALS). We have reported that TDP-43 and phosphorylated Smad2 (pSmad2), an intracellu... | Activation of the TGFβ/Smad signaling system is protective against aggregate formation of cytoplasmically mislocalized TDP-43 and may be a potential therapeutic approach to delay progression of ALS. | yes |
22,781,777 | Do [ Epitopic multiple antigen peptide from α-fetoprotein elicit antitumor immune response in vitro and ex vivo ]? | {
"contexts": [
"To explore the antitumor effects of multiple antigen peptide (MAP) vaccine from α-fetoprotein (AFP) through AFP-specific cytotoxic T lymphocyte (CTL) against hepatoma in vitro and ex vivo.",
"Dendritic cells (DC) were generated from human peripheral blood mononuclear cells (PBMC) and HLA-A2.1... | AFP multiple antigen peptides elicit not only more powerful specific anti-tumor immune responses but also stronger non-specific anti-tumor immune activities than their corresponding linear peptides. These findings will provide theoretical rationales for their clinical applications. | yes |
22,803,432 | Does [ Lingmao recipe inhibit starvation induced autophagy in HepG2.2.15 cell ]? | {
"contexts": [
"To study the effects of Lingmao Recipe (LR) on starvation-induced autophagy in HepG 2.2.15 cell.",
"Fifteen SD rats were selected to prepare LR drug serum. The Earle's balanced salt solution (EBSS) group, the EBSS + vehicle serum group, the EBSS + 5 times LR serum group, the EBSS + 10 times L... | LR could inhibit starvation-induced autophagy in HepG 2.2.15. | yes |
22,789,805 | Does tissue engineering approach to degenerative disc disease -- a meta-analysis of controlled animal trials? | {
"contexts": [
"The objective of this systematic review was to assess cell/biomaterial treatments of degenerative disc disease in controlled animal trails. The primary endpoints were restoration of disc height and T2 signal intensity.",
"PubMed, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials ... | Treatment of an injured/degenerating disc with cells, cells plus biomaterial or biomaterial alone has a potential for at least a partial regeneration of the disc. However, so far, none of the treatments is able to effectively restore the properties of a healthy disc. | yes |
22,796,708 | Is age-associated increase in salt sensitivity accompanied by a shift in the atrial natriuretic peptide modulation of the effect of marinobufagenin on renal and vascular sodium pump? | {
"contexts": [
"Marinobufagenin (MBG) promotes natriuresis via inhibition of renotubular Na/K-ATPase (NKA) and causes vasoconstriction via inhibition of vascular NKA. Atrial natriuretic peptide (ANP), via cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG)-dependent mechanism, sensitizes renal NKA to MB... | Age-associated downregulation of cGMP/PKG-dependent signaling impairs the ability of ANP to modulate the effects of MBG on the sodium pump, which contributes to salt sensitivity. | yes |
22,798,136 | Does pelvic morphology differ in rotation and obliquity between developmental dysplasia of the hip and retroversion? | {
"contexts": [
"Developmental dysplasia of the hip (DDH) and acetabular retroversion represent distinct acetabular pathomorphologies. Both are associated with alterations in pelvic morphology. In cases where direct radiographic assessment of the acetabulum is difficult or impossible or in mixed cases of DDH and ... | Pelvic morphology is associated with acetabular pathomorphology. Our measurements, except the AIIS sign, are indirect indicators of acetabular retroversion. The data suggest they can be used when the acetabular rim is not clearly visible and retroversion is not obvious. | yes |
22,785,600 | Is the matrix metalloproteinase 2-1575 gene polymorphism associated with the risk of developing myocardial infarction in Mexican patients? | {
"contexts": [
"Was to evaluate the role of seven matrix metalloproteinase (MMP) polymorphisms in the genetic susceptibility to develop myocardial infarction in Mexican individuals.",
"Seven polymorphisms in the MMP genes were genotyped by 5' exonuclease TaqMan genotyping assays in 300 patients with myocardi... | The results suggest that the MMP2-1575 (rs243866) gene polymorphism could be involved in the risk of developing myocardial infarction in Mexican individuals. | yes |
22,804,631 | Does expression of vascular endothelial growth factor-C in primary cutaneous melanoma predict sentinel lymph node positivity? | {
"contexts": [
"Vascular endothelial growth factor-C (VEGF-C), a lymphatic vessel growth factor, has been involved in the formation of lymph nodal metastases in different tumor types. Early evidences indicate that VEGF-C expression in human primary melanoma could be predictive of lymph nodal metastases, whereas ... | Our results, taking into account the expression of either VEGF-C or related histopathological markers, indicated the possibility to use VEGF-C immunohistochemistry as a marker of metastatic progression, especially in thin cutaneous melanomas. | yes |
22,772,342 | Is tUFM a potential new prognostic indicator for colorectal carcinoma? | {
"contexts": [
"Mitochondrial Tu translation elongation factor (TUFM) is a nuclear encoded protein that participates in mitochondrial polypeptide translation. TUFM has been reported to be over-expressed in many tumour types including colorectal carcinoma (CRC) by proteomics. The present study aims to examine the... | Increased expression of TUFM is a promising new prognostic indicator for CRC. Selective inhibition of TUFM in tumour cells may present a new avenue for the targeted therapy of this cancer. | yes |
22,798,324 | Is higher plasma fractalkine associated with better 6-month outcome from ischemic stroke? | {
"contexts": [
"Fractalkine (CX3CL1) is a unique chemokine that is constitutively expressed on neurons where it serves as an adhesion molecule for lymphocytes and monocytes. CX3CL1 may also be cleaved from the surface of these cells and enter the circulation to act as a traditional chemokine. CX3CL1 could thus i... | In contrast to our original hypothesis, lower concentrations of CX3CL1 are associated with worse stroke outcome. In light of recent studies suggesting an immunomodulatory and neuroprotective role for CX3CL1 in a variety of neurodegenerative diseases, a therapeutic role for CX3CL1 in stroke recovery should be considered... | yes |
22,768,175 | Does cRF induce intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α? | {
"contexts": [
"Psychological stress is a predisposing factor in the onset and exacerbation of important gastrointestinal diseases including irritable bowel syndrome (IBS) and the inflammatory bowel diseases (IBD). The pathophysiology of stress-induced intestinal disturbances is known to be mediated by corticotr... | These data demonstrate that CRF triggers increases in intestinal paracellular permeability via mast cell dependent release of TNF-α and proteases. Furthermore, CRF-mast cell signaling pathways and increases in intestinal permeability require critical input from the enteric nervous system. Therefore, blocking the delete... | yes |
22,801,340 | Is cervical intraepithelial neoplasia associated with genital tract mucosal inflammation? | {
"contexts": [
"Clinical studies demonstrate increased prevalence of human papillomavirus (HPV)-associated disease in HIV-infected individuals and an increased risk of HIV acquisition in HPV-infected individuals. The mechanisms underlying this synergy are not defined. We hypothesize that women with cervical intr... | HRHPV+ CIN is characterized by changes in soluble mucosal immunity that could contribute to HPV persistence. The observed mucosal inflammation suggests a mechanism that may also contribute to the epidemiologic link between persistent HPV and HIV. | yes |
22,777,053 | Does neither neoadjuvant nor adjuvant therapy increase survival after biliary tract cancer resection with wide negative margins? | {
"contexts": [
"We investigated the role of neoadjuvant/adjuvant therapies on survival for resectable biliary tract cancer. We hypothesized that neoadjuvant and adjuvant therapy should improve the survival probability in these patients.",
"This was a retrospective review of a prospective database of patients... | Early surgical resection of biliary tract malignancies with 1 cm tumor-free margins provides the best probability for long-term survival. Currently available neoadjuvant or adjuvant therapy does not improve survival. | yes |
22,789,523 | Do antenatal depressive symptoms increase the likelihood of preterm birth? | {
"contexts": [
"We evaluated the relationship between antenatal depressive symptoms and preterm birth.",
"Patients completed the Edinburgh Postnatal Depression Scale between 24-28 weeks of gestation. A score ≥ 12 (or thoughts of self-harm) indicated an at-risk woman. Symptomatic women were compared to risk-n... | In this large cohort of prenatally screened women, those with depressive symptoms had an increased likelihood of preterm birth. | yes |
22,782,605 | Is six-minute walk distance related to quality of life in patients with non-cystic fibrosis bronchiectasis? | {
"contexts": [
"To evaluate physical performance on the six-minute walk test (6MWT) in patients with non-cystic fibrosis bronchiectasis and to investigate its relationship with quality of life (QoL). To identify predictors of exercise performance, we also investigated whether six-minute walk distance (6MWD) is a... | In this sample, there was a high proportion of patients who presented a lower than expected 6MWD. Although 6MWD was not related to QoL, it was associated with age and BMI. | no |
22,775,981 | Is treatment of Haemophilus bacteremia with benzylpenicillin associated with increased ( 30-day ) mortality? | {
"contexts": [
"Optimal antibiotic treatment strategies of Haemophilus infections are still needed. Therefore, 30-day case fatality rate (CFR) of Haemophilus bacteremia and efficacy of various antibiotic treatment regimes were studied.",
"All episodes of Haemophilus bacteremia in the former Copenhagen County... | Our results suggest that, after susceptibility testing, cefuroxime or aminopenicillins are preferable to benzylpenicillins as definitive therapy for Haemophilus bacteremia. | yes |
22,785,605 | Do bony adaptation of the proximal humerus and glenoid correlate within the throwing shoulder of professional baseball pitchers? | {
"contexts": [
"Elite throwing athletes have increased proximal humeral retrotorsion (HRT) and glenoid retroversion (GRV) in their throwing shoulders compared with their nonthrowing shoulders. These adaptive morphologic changes are thought to be independently protective against shoulder injury; however, their re... | The concurrent increases in dominant shoulder HRT and GRV were observed as a 2:1 "thrower's ratio." As this relationship was not observed on the nondominant shoulder, it suggests that bony adaptation of the proximal humerus and glenoid are coupled during skeletal development in the throwing shoulder. Longitudinal studi... | yes |
22,768,238 | Does a microRNA-7 binding site polymorphism in HOXB5 lead to differential gene expression in bladder cancer? | {
"contexts": [
"To investigate the biological function of HOXB5 in human bladder cancer and explore whether the HOXB5 3'-UTR SNP (1010A/G), which is located within the microRNA-7 binding site, was correlated with clinical features of bladder cancer.",
"Expression of HOXB5 in 35 human bladder cancer tissues a... | HOXB5 is overexpressed in bladder cancer. A miRNA-binding SNP (1010A/G) located within 3'-UTR of HOXB5 is associated with gene expression and may be a promising prognostic factor for bladder cancer. | yes |
22,777,528 | Does cryptorchidism-induced CFTR down-regulation result in disruption of testicular tight junctions through up-regulation of NF-κB/COX-2/PGE2? | {
"contexts": [
"Does elevated temperature-induced cystic fibrosis transmembrane conductance regulator (CFTR) down-regulation in Sertoli cells in cryptorchid testis disrupt testicular tight junctions (TJs) through the nuclear factor kappa B (NF-κB)/cyclooxygenase-2 (COX-2)/prostaglandin E(2) (PGE(2)) pathway?"
... | Our results suggest that CFTR may be involved in regulating testicular TJs and the blood-testis barrier (BTB) through its negative regulation of the NF-κB/COX-2/PGE(2) pathway in Sertoli cells, a defect of which may result in the spermatogenesis defect in cryptorchidism. | yes |
22,781,835 | Does prolonged hyperoxia preconditioning attenuate behavioral symptoms of 6-hydroxydopamine-induced Parkinsonism? | {
"contexts": [
"Several lines of evidences show that hyperoxia preconditioning provides neuronal protection against central nervous system ischemic damages. Common pathways including mitochondrial dysfunction, apoptosis, and caspase activation are involved in acute neurodegeneration (e.g. after cerebral ischemia... | Our findings show that the prolonged hyperoxia preconditioning attenuates the behavioral symptoms of 6-OHDA-induced Parkinsonism. Considering the well-known correlation between dopaminergic neuronal death in the substantia nigra and the behavioral symptoms of 6-OHDA-induced Parkinsonism, it could be speculated that the... | yes |
22,775,424 | Does yoga training improve quality of life in women with asthma? | {
"contexts": [
"Individuals with asthma frequently suffer with a decrease in quality of life. Yoga has been shown to improve autonomic function in the healthy population and has been used as an alternative therapy to help improve symptoms associated with various diseases.",
"The purpose of this study was to ... | Yoga training improved quality of life in women with mild-to-moderate asthma and resulted in decreased parasympathetic and increased sympathetic modulation in response to an IFE. | yes |
22,783,345 | Are hepatitis B Virus Genotype B and High Expression of Interferon Alpha Receptor β Subunit Associated With Better Response to Pegylated Interferon Alpha 2a in Chinese Patients With Chronic Hepatitis B Infection? | {
"contexts": [
"Hepatitis B virus (HBV) is one of leading causes of various hepatic diseases including acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Hundreds of million people worldwide are infected by HBV, chronically.",
"This study in conducted to investigate the influence of Hepatit... | HBV genotype B and high expression of IFNAR2 in the liver of chronic hepatitis B patients are closely associated with better response to Peg-IFN-α-2a therapy in chronic hepatitis B disease. | yes |
22,771,507 | Does population-based study reveal new risk-stratification biomarker panel for Barrett 's esophagus? | {
"contexts": [
"The risk of progression of Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) is low and difficult to calculate. Accurate tools to determine risk are needed to optimize surveillance and intervention. We assessed the ability of candidate biomarkers to predict which cases of BE will progre... | Low-grade dysplasia, abnormal DNA ploidy, and AOL can be used to identify patients with BE most likely to develop EAC or high-grade dysplasia. | yes |
22,771,508 | Does β-Catenin regulate deiodinase levels and thyroid hormone signaling in colon cancer cells? | {
"contexts": [
"Activation of the β-catenin/T-cell factor (TCF) complex occurs in most colon tumors, and its actions correlate with the neoplastic phenotype of intestinal epithelial cells. Type 3 deiodinase (D3), the selenoenzyme that inactivates thyroid hormone (3,5,3' triiodothyronine [T3]), is frequently expr... | Deiodinases are at the interface between the β-catenin and the thyroid hormone pathways. Their synchronized regulation of intracellular T3 concentration is a hitherto unrecognized route by which the multiple effects of β-catenin are generated and may be targeted to reduce the oncogenic effects of β-catenin in intestina... | yes |
22,780,848 | Is plasma free choline a novel non-invasive biomarker for early-stage non-alcoholic steatohepatitis : A multi-center validation study? | {
"contexts": [
" Choline is a dietary component that is crucial for normal cellular function. Choline is predominantly absorbed from the small intestine and completely metabolized in the liver. We recently demonstrated that free choline (fCh) levels in blood reflect the level of phosphatidylcholine synthesis in... | Plasma fCh levels are closely related to the grade of liver steatosis and fibrosis, and predict NASH severity. Plasma fCh levels are therefore a potential diagnostic marker for early-stage NASH in clinical practice. | yes |
22,785,526 | Does sUV on dual-phase FDG PET/CT correlate with the Ki-67 proliferation index in patients with newly diagnosed non-Hodgkin lymphoma? | {
"contexts": [
"PET using 18F-FDG integrated with CT is beneficial for staging patients with non-Hodgkin lymphoma (NHL). The Ki-67 index is used to assess the proliferation potential of tumor cells. The aim of this study was to evaluate the correlation of the Ki-67 index in tissue samples with the SUV at differe... | For patients with newly diagnosed NHL, the significant correlation between the Ki-67 index and the SUV in this study suggests that dual-phase FDG PET/CT may be used as a noninvasive measurement of tumor proliferation. | yes |
22,780,099 | Does cortical stimulation mapping and Wada result demonstrate a normal variant of right hemisphere language organization? | {
"contexts": [
"Exclusive right hemisphere language lateralization is rarely observed in the Wada angiography results of epilepsy surgery patients. Cortical stimulation mapping (CSM) is infrequently performed in such patients, as most undergo nondominant left hemisphere resections, which are presumed not to pose... | Results suggest that the Wada procedure is a valid measure for identifying right hemisphere language processing without any false lateralization found in the patients mapped with CSM (i.e., a positive Wada is 100% sensitive for finding right hemisphere language sites), and that the distribution of language sites is con... | yes |
22,798,109 | Do helicobacter pylori infection and administration of non-steroidal anti-inflammatory drugs down-regulate the expression of gastrokine-1 in gastric mucosa? | {
"contexts": [
"Gastrokine-1 is a novel protein that plays an important role in the maintenance of the integrity of the gastric mucosa. However, whether Helicobacter pylori infection and non-steroidal anti-inflammatory drugs, which are known to cause gastric mucosal injuries, affect gastrokine-1 expression in th... | Both Helicobacter pylori infection and long-term non-steroidal anti-inflammatory drug administration downregulate gastrokine-1 expression in the gastric mucosa, which may contribute to the gastric mucosal injuries induced by these two factors. | yes |
22,790,352 | Is perihepatic lymph node enlargement a negative predictor of liver cancer development in chronic hepatitis C patients? | {
"contexts": [
"Perihepatic lymph node enlargement (PLNE) is a common ultrasound finding in chronic hepatitis C patients. Although PLNE is considered to reflect the inflammatory response to hepatitis C virus (HCV), its clinical significance remains unclear.",
"Between December 2004 and June 2005, we enrolled... | Patients with PLNE had a lower risk of HCC development than those without PLNE. This study may provide new insights into daily clinical practice and the pathophysiology of HCV-induced hepatitis and hepatocarcinogenesis. | yes |
22,792,233 | Does a novel survival-based tissue microarray of pancreatic cancer validate MUC1 and mesothelin as biomarkers? | {
"contexts": [
"One-fifth of patients with seemingly 'curable' pancreatic ductal adenocarcinoma (PDA) experience an early recurrence and death, receiving no definable benefit from a major operation. Some patients with advanced stage tumors are deemed 'unresectable' by conventional staging criteria (e.g. liver me... | MUC1 and MSLN were superior to pathologic features and other putative biomarkers as predicting survival group. Molecular assays comparing cancers from short and long survivors are an effective strategy to screen biomarkers and prioritize candidate cancer genes for diagnostic and therapeutic studies. | yes |
22,791,765 | Does chemerin regulate NK cell accumulation and endothelial cell morphogenesis in the decidua during early pregnancy? | {
"contexts": [
"Although decidual natural killer (NK) cell accumulation and vascular remodeling are critical steps to ensure successful pregnancy, the molecular mechanisms controlling these events are poorly defined.",
"Herein we analyzed whether chemerin, a recently identified chemoattractant involved in ma... | Our data indicate that chemerin is up-regulated during decidualization and might contribute to NK cell accumulation and vascular remodeling during early pregnancy. | yes |
22,791,762 | Are decreased lectin-like oxidized LDL receptor 1 ( LOX-1 ) and low Nrf2 activation in placenta involved in preeclampsia? | {
"contexts": [
"Serum concentration of oxidized low-density lipoprotein (oxLDL) is higher in women with preeclampsia than in normal pregnant woman. Lectin-like oxLDL receptor-1 (LOX-1) is one of the scavenger receptors for oxLDL and is abundantly expressed in placenta. It is well known that oxLDL activates nucle... | Decreasing LOX-1 expression in preeclamptic placenta may contribute to high oxLDL concentration, low Nrf2 activation, and low HO-1 expression. These findings provide novel insights into the crucial role of LOX-1 and Nrf2 in the pathogenesis of preeclampsia. | yes |
22,792,371 | Is 17β-Hydroxysteroid dehydrogenase type 14 a predictive marker for tamoxifen response in oestrogen receptor positive breast cancer? | {
"contexts": [
"17β-Hydroxysteroid dehydrogenases (17βHSDs) are important enzymes regulating the pool of bioactive steroids in the breast. The current study was undertaken in order to evaluate implications of 17βHSD14 in breast cancer, measuring 17βHSD14 protein expression in breast tumours.",
"An antibody t... | Using a highly specific validated antibody for immunohistochemical analysis of a large number of breast tumours, we have shown that tumoural expression levels of 17βHSD14 can predict the outcome of adjuvant tamoxifen treatment in terms of local recurrence-free survival in patients with lymph node-negative ER+ breast ca... | yes |
22,776,878 | Does genetic variation of SCNN1A influence lung diffusing capacity in cystic fibrosis? | {
"contexts": [
"Epithelial Na channels (ENaCs) play a crucial role in ion and fluid regulation in the lung. In cystic fibrosis (CF), Na hyperabsorption results from ENaC overactivity, leading to airway dehydration. Previous work has demonstrated functional genetic variation of SCNN1A (the gene encoding the ENaC ... | These results suggest that genetic variation of the α-subunit of ENaC differentially affects the diffusing capacity response to exercise in patients with CF. | yes |
22,776,877 | Is carotid inflammation unaltered by exercise in hypercholesterolemic Swine? | {
"contexts": [
"Reduction of vascular inflammation might contribute to the beneficial effects of exercise. We hypothesized that 1) exercise would reduce carotid endothelial vascular cell adhesion molecule-1 (VCAM-1) and that 2) in vivo detection of carotid inflammation can be achieved in a large animal model usi... | These results first demonstrate that aerobic exercise has no effect on carotid endothelial inflammatory markers and EDD in FH swine. Second, our findings indicate that CEU using VCAM-1-targeted MBs can detect inflammation in vivo, providing strong foundations for longitudinal studies examining the effect of therapeutic... | yes |
22,796,933 | Are personality traits of the five-factor model associated with effort-reward imbalance at work : a population-based study? | {
"contexts": [
"This study examined the association between personality traits and work stress.",
"The sample comprised 757 women and 613 men (aged 30 to 45 years in 2007) participating in the Young Finns study. Personality was assessed with the NEO-FFI questionnaire and work stress according to Siegrist's e... | This study suggests that personality traits may predispose to and protect from work stress. | yes |
22,785,410 | Is body mass index independently associated with increased aortic stiffness in a Brazilian population? | {
"contexts": [
"Obesity has been described as a predictor of cardiovascular mortality, and some studies have reported an association with obesity and increased aortic stiffness. Other studies have not identified obesity to be an independent risk factor. Therefore, the purpose of our study was to determine the as... | In conclusion, our study failed to provide evidence of a positive, blood pressure (BP)-independent association between obesity on aortic stiffness. Our data suggests that the previously reported finding of an association between obesity and aortic stiffness was probably confounded by the progressive increase in BP obse... | no |
22,801,061 | Is the Glasgow Blatchford score the most accurate assessment of patients with upper gastrointestinal hemorrhage? | {
"contexts": [
"Risk scoring systems are used increasingly to assess patients with upper gastrointestinal hemorrhage (UGIH). There have been comparative studies to identify the best system, but most have been retrospective and included small sample sizes, few patients with severe bleeding and with low mortality.... | The GBS accurately identifies patients with UGIH most likely to need hospital-based intervention and also those best suited for outpatient care. The EGBS seems promising but must be validated externally. No scoring system seems to accurately predict patients' 30-day mortality or rebleeding. ClinicalTrials.gov number, N... | yes |
22,801,062 | Is the combination of octreotide and midodrine superior to albumin in preventing recurrence of ascites after large-volume paracentesis? | {
"contexts": [
"Large-volume paracentesis (LVP) is the treatment of choice for patients with cirrhosis and refractory ascites. However, LVP can lead to postparacentesis circulatory dysfunction (PCD), which is associated with faster ascites recurrence and renal failure. PCD results from vasodilatation, which redu... | The combination of midodrine and octreotide after LVP is not superior to albumin in delaying recurrence of ascites or preventing PCD in patients with cirrhosis. Outcomes appear to be worse in patients given octreotide and midodrine. ClinicalTrials.gov number, NCT00108355. | no |
22,796,407 | Does regular in situ simulation training of paediatric medical emergency team improve hospital response to deteriorating patients? | {
"contexts": [
"The introduction of a paediatric medical emergency team (pMET) was accompanied by integration of weekly in situ simulation team training into routine clinical practice. On a rotational basis, all key ward staff participated in team training, which focused on recognition of the deteriorating child... | These results indicate that lessons learnt by ward staff during regular in situ team training led to significantly improved recognition and management of deteriorating in-patients with evolving critical illness. Integration of in situ simulation team training in clinical care has potential applications beyond paediatri... | yes |
22,796,404 | Does smartphone technology enhance newborn intubation knowledge and performance amongst paediatric trainees? | {
"contexts": [
"Smartphones are widely used by physicians, but their effectiveness in improving teaching of clinical skills is not known. The aim of this study was to determine if pre procedural use of a smartphone neonatal intubation instructional application (NeoTube) improves trainee knowledge and enhances pr... | Bedside use of smartphones can enhance both knowledge of newborn intubation and improves procedural performance, including reducing the time to successfully intubate. Smartphones may have a useful role in bringing procedural skills training closer to the bedside. | yes |
22,791,174 | Do intraoperative sclerotomy-related retinal breaks during 23-gauge pars plana vitrectomy? | {
"contexts": [
"To study the incidence and characteristics of intraoperative sclerotomy-related retinal breaks encountered during 23-gauge pars plana vitrectomy.",
"A retrospective consecutive case series was assembled from the surgical logs and charts of patients who underwent 23-gauge pars plana vitrectomy... | Pars plana vitrectomy (23-gauge) is associated with a low incidence of sclerotomy-related retinal breaks and postoperative retinal detachments. Eyes with breaks are more likely to be phakic and without a preoperative posterior vitreous detachment. The presence of vitreomacular traction may be a risk factor for the deve... | yes |
22,802,109 | Does combined use of etanercept and MTX restore CD4⁺/CD8⁺ ratio and Tregs in spleen and thymus in collagen-induced arthritis? | {
"contexts": [
"To further explore the mechanism of etanercept (ENT, rhTNFR:Fc) and methotrexate (MTX) in the combined treatment of rheumatoid arthritis (RA), we investigated whether thymic and splenic T-cell subsets and their related cytokines imbalance could be restored by ETN/MTX treatment.",
"The effect ... | Taken together, our findings suggest that ENT/MTX may modify the abnormal T lymphocytes balance from central to peripheral lymphoid organs, which may partially, explained the mechanism of the combined administration. | yes |
22,794,509 | Is fluoroquinolone exposure prior to tuberculosis diagnosis associated with an increased risk of death? | {
"contexts": [
"Fluoroquinolone (FQ) exposure before tuberculosis (TB) diagnosis is common, but its effect on outcomes, including mortality, is unclear.",
"Among TB patients reported to the Tennessee Department of Health from 2007 to 2009, we assessed FQ exposure within 6 months before TB diagnosis. The pri... | Among this patient population, FQ exposure before TB diagnosis was associated with an increased risk of death. These findings underscore the need for cautious use of FQs in persons with possible TB. | yes |
22,779,363 | Do [ Quick identification of sun-dried and sulfur-fumigated angelicae sinensis radix by Fourier transform infrared spectroscopy ]? | {
"contexts": [
"To develop a quick identification method for the sun-dried and sulfur-fumigated Angelicae Sinensis Radix used by Fourier transform infrared spectroscopy (FTIR) combined with second derivative infrared spectroscopy.",
"The alcoholic and aqueous extracts of sun-dried and sulfur-fumigated Angeli... | The FTIS method combined with second derivative can be utilized to distinguish sun-dried and sulfur-fumigated Angelicae Sinensis Radix efficiently, conveniently and accurately, and provide a basis for identification and quality control of Angelicae Sinensis Radix. | yes |
22,782,351 | Does tIGAR induce p53-mediated cell-cycle arrest by regulation of RB-E2F1 complex? | {
"contexts": [
"p53 induces cell-cycle arrest and apoptosis in cancer cells and negatively regulates glycolysis via TIGAR. Glycolysis is crucial for cancer progression although TIGAR provides protection from reactive oxygen species and apoptosis. The relation between TIGAR-mediated inhibition of glycolysis and p... | TIGAR mediates de-phosphorylation of RB and stabilisation of RB-E2F1 complex thus delaying the entry of cells in S phase of the cell cycle. Thus, TIGAR inhibits proliferation of cancer cells and increases drug-mediated tumour regression by promoting p53-mediated cell-cycle arrest. | yes |
22,773,569 | Do tumor-educated macrophages promote tumor growth and peritoneal metastasis in an orthotopic nude mouse model of human pancreatic cancer? | {
"contexts": [
"Macrophages promote tumor growth by stimulating tumor-associated angiogenesis, cancer-cell invasion, migration, intravasation, and suppression of antitumor immune responses.",
"Ten transgenic nude mice, ubiquitously expressing green fluorescent protein (GFP), were injected subcutaneously with... | These results suggest that macrophages influence tumors, and tumors influence macrophages, and tumor-educated promote tumor progression. Tumor-educated macrophages may be a target for therapy of metastatic cancer. | yes |
22,781,708 | Does eRK inhibition enhance TSA-induced gastric cancer cell apoptosis via NF-κB-dependent and Notch-independent mechanism? | {
"contexts": [
"To analyze the combined impact of the histone deacetylase inhibitor (HDACI) Trichostatin A (TSA) and the extracellular-signal-regulated kinase 1/2 (ERK1/2) inhibitor PD98059 on gastric cancer (GC) cell line SGC7901 growth.",
"SGC7901 cells were treated with TSA, PD98059 or with a TSA-PD98059 ... | PD98059 synergistically potentiates TSA-induced GC growth arrest and apoptosis by manipulating NF-κB and p21(WAF1/CIP1) independent of Notch. Therefore, concomitant administration of HDACIs and ERK1/2 inhibitors may be a promising treatment strategy for individuals with GC. | yes |
22,788,747 | Does dipeptidyl peptidase-4 inhibitor improve neovascularization by increasing circulating endothelial progenitor cells? | {
"contexts": [
"Current methods used to treat critical limb ischaemia (CLI) are hampered by a lack of effective strategies, therefore, therapeutic vasculogenesis may open up a new field for the treatment of CLI. In this study we investigated the ability of the DPP-4 inhibitor, sitagliptin, originally used as a h... | Circulating EPC levels and neovasculogenesis were augmented by the DPP-4 inhibitor, sitagliptin and this effect was dependent on an eNOS-related pathway in a mouse model of hindlimb ischaemia. The results indicate that oral administration of sitagliptin has therapeutic potential as an inducer of vasculogenesis. | yes |
22,768,647 | Does above-real-time training ( ARTT ) improve transfer to a simulated flight control task? | {
"contexts": [
"The aim of this study was to measure the effects of above-real-time-training (ARTT) speed and screen resolution on a simulated flight control task.",
"ARTT has been shown to improve transfer to the criterion task in some military simulation experiments. We tested training speed and screen res... | ARTT followed by criterion training improves performance on a visual-motor coordination task. We think that ARTT influences known facilitators of transfer, including similarity to the criterion task and contextual interference. | yes |
22,784,474 | Does [ Storage at room temperature change cisatracurium onset time : a prospective , randomized , double-blind controlled study ]? | {
"contexts": [
"Storage of cisatracurium at room temperature seems to have no effect on its degradation in vitro contrary to the recommendations of storage at +4°C. The purpose of this study was to evaluate the influence of cisatracurium' s storage temperature on its onset time.",
"Prospective, randomized, d... | This study demonstrated that cisatracurium's storage at room temperature had no influence on its onset time. It provides an argument for the preservation of cisatracurium at room temperature for a period not exceeding 21 days. Monitoring the onset of curarization may increase the quality score of intubation. | no |
22,796,714 | Does l-Carnitine prevent the development of ventricular fibrosis and heart failure with preserved ejection fraction in hypertensive heart disease? | {
"contexts": [
"Prognosis of heart failure with preserved ejection fraction (HFpEF) remains poor because of unknown pathophysiology and unestablished therapeutic strategy. This study aimed to identify a potential therapeutic intervention for HFpEF through metabolomics-based analysis.",
"Metabolomics with cap... | L-carnitine supplementation attenuates cardiac fibrosis by increasing prostacyclin production through arachidonic acid pathway, and may be a promising therapeutic option for HFpEF. | yes |
22,784,482 | Do prescription dose and fractionation predict improved survival after stereotactic radiotherapy for brainstem metastases? | {
"contexts": [
"Brainstem metastases represent an uncommon clinical presentation that is associated with a poor prognosis. Treatment options are limited given the unacceptable risks associated with surgical resection in this location. However, without local control, symptoms including progressive cranial nerve d... | SRT/SRS for brainstem metastases is safe and achieves a high rate of local control. We found higher GPA as well as greater number of treatment fractions and higher prescription dose to be correlated with improved overall survival. Despite this approach, prognosis remains poor and distant intracranial control remains an... | yes |
22,796,266 | Are polymorphisms of tumor-related genes IL-10 , PSCA , MTRR and NOC3L associated with the risk of gastric cancer in the Chinese Han population? | {
"contexts": [
"Gastric cancer is the fourth most common cancer in the world. Environmental and genetic factors both play critical roles in the etiology of gastric cancer. Hundreds of SNPs have been identified to have association with the risk of gastric cancer in many races. In this study, 25 SNPs in genes for ... | These results indicate the importance of four gastric cancer susceptibility polymorphisms of IL-10, NOC3L, PSCA and MTRR in the Chinese Han population, which could be used in the determination of gastric cancer risk in clinical practice. | yes |
22,801,564 | Is high density lipoprotein positively correlated with the changes in circulating total adiponectin and high molecular weight adiponectin during dietary and fenofibrate treatment? | {
"contexts": [
"The investigation of the relationship between high density lipoprotein (HDL) and adiponectin.",
"Thirty-seven obese or overweight [body mass index ≥27 Kg/m(2)], hypertriglyceridemic patients underwent one of the following interventions for 3 months: 1) Low-calorie diet (n=19), 2) Low-calorie ... | HDL is positively correlated with the changes in circulating adiponectin during dietary and fenofibrate treatment. | yes |
22,800,940 | Does sLEDAI-2K Responder Index 50 capture 50 % improvement in disease activity over 10 years? | {
"contexts": [
"To determine the frequency and the time to complete recovery identified by Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) and the time to partial recovery identified by the SLEDAI-2K Responder Index 50 (SRI-50) in three laboratory systems over 10 years.",
"This is a retr... | The SRI-50 is a valid responder index derived form SLEDAI-2K and is very helpful in identifying clinically important improvement in active laboratory descriptors in an efficient time. | yes |
22,800,947 | Do [ Positron emission tomography plus VEEG in the localization of epileptic foci in negative-MRI interact epilepsy ]? | {
"contexts": [
"To explore the application value of positron emission tomography (PET) in the localization of magnetic resonance imaging (MRI)-negative epileptogenic focus.",
"Brain images of 18fluoro-2-deoxy-D-glucose (18F-FDG) and 13N-NH3·H2O-PET, MRI and video electroencephalography (VEEG) were obtained i... | PET imaging is both sensitive and effective in the detection and localization of epileptogenic foci. Especially for MRI-negative cases, it is an indispensable tool of localizing epileptogenic foci. | yes |
22,787,341 | Does use of a furosemide drip improve earlier primary fascial closure in the open abdomen? | {
"contexts": [
"The furosemide drip (FD), in addition to improving volume overload respiratory failure, has been used to decrease fluid in attempts to decrease intra-abdominal and abdominal wall volumes to facilitate fascial closure. The purpose of this study is to evaluate the FD and the associated rate of prim... | FD use may remove excess volume; however, forced diuresis with an FD is not associated with an increased rate of primary closure after DCL. Further studies are warranted to identify ICU strategies to facilitate fascial closure in DCL. | no |
22,775,222 | Does ajuga iva aqueous extract improve reverse cholesterol transport in streptozotocin-induced diabetic rat? | {
"contexts": [
"The aim of this study was to determine the effects of Ajuga iva aqueous extract on lecithin : cholesterol acyltransferase (LCAT) activity and amount and composition of high-density lipoprotein (HDL)(2) and (HDL)(3), in streptozotocin (STZ)-induced diabetic rats.",
"Diabetes was induced in mal... | In STZ-induced diabetic rats, A. iva improves reverse cholesterol transport by enhancing LCAT activity, leading to anti-atherogenic effects. | yes |
22,801,243 | Does gastroretentive gabapentin ( G-GR ) formulation reduce intensity of pain associated with postherpetic neuralgia ( PHN )? | {
"contexts": [
"To evaluate the safety and efficacy of a once-daily gastroretentive formulation of gabapentin (G-GR; 1800 mg).",
"This was an 11-week, double-blind, randomized, placebo-controlled Phase 3 clinical trial in patients with postherpetic neuralgia. Patients underwent a 2-week dose titration, 8 wee... | Once-daily G-GR 1800 mg was effective and well tolerated for the relief of pain in patients with postherpetic neuralgia. | yes |
22,778,673 | Do specialized ambulatory anesthesia teams contribute to decreased ambulatory surgery recovery room length of stay? | {
"contexts": [
"Many institutions have organized specialized groups of ambulatory surgery anesthesiologists with the aim of improving ambulatory surgery patient care and efficiency. We hypothesized that specialized ambulatory anesthesia teams produce better patient outcomes such as lower postoperative nausea and... | The decreased PACU LOS for the study group's patients occurred despite the increased incidence of PONV. Ambulatory anesthesiologists contributed to decreased PACU LOS while practicing evidence-based anesthesia with regard to PONV and pain control. Ambulatory subspecialization may benefit institutions as a way to increa... | yes |
22,776,446 | Is the majority of dorsal spinal cord gastrin releasing peptide synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons? | {
"contexts": [
"Itch is one of the major somatosensory modalities. Some recent findings have proposed that gastrin releasing peptide (Grp) is expressed in a subset of dorsal root ganglion (DRG) neurons and functions as a selective neurotransmitter for transferring itch information to spinal cord interneurons. Ho... | The majority of dSC Grp is synthesized locally in dorsal spinal cord neurons. On the other hand, Nmb is highly expressed in pain- and itch-sensing DRG neurons. Our findings provide direct anatomic evidence that Grp could function locally in the dorsal spinal cord in addition to its roles in DRG neurons and that Nmb has... | yes |
22,801,737 | Is postoperative morbidity an additional prognostic factor after potentially curative pancreaticoduodenectomy for primary duodenal adenocarcinoma? | {
"contexts": [
"The aims of this paper were to evaluate the clinical features of patients with primary duodenal adenocarcinoma and to address the prognostic relevance of different surgical and pathological variables after potentially curative pancreaticoduodenectomy.",
"Patients with primary duodenal adenoca... | According to the present findings, the development of postoperative complications may be an additional prognostic factor after potentially curative pancreaticoduodenectomy for primary duodenal adenocarcinoma. This emphasizes the need for centralization to high-volume centers where an appropriate postoperative care can ... | yes |
22,797,131 | Does monitoring breathing rate at home allow early identification of COPD exacerbations? | {
"contexts": [
"Respiratory frequency increases during exacerbations of COPD (ECOPD). We hypothesized that this increase can be detected at home before ECOPD hospitalization.",
"To test this hypothesis, respiratory frequency was monitored at home daily for 3 months in 89 patients with COPD (FEV₁, 42.3% ± 14.... | Respiratory frequency can be monitored daily at home in patients with COPD receiving domiciliary oxygen therapy. In these patients, breathing rate increases significantly days before they require hospitalization because of ECOPD. This may offer a window of opportunity for early intervention. | yes |
22,766,687 | Do wedge volume and osteotomy surface depend on surgical technique for distal femoral osteotomy? | {
"contexts": [
"Biplanar distal femoral osteotomy (DFO) is thought to promote rapid bone healing due to the increased cancellous bone surface compared to other DFO techniques. However, precise data on the bone surface area and wedge volume resulting from both open- and closed-wedge DFO techniques remain unknown.... | Bone geometry following DFO suggests that the medial biplanar closed-wedge technique simultaneously creates smaller wedge volume and larger bone surface areas compared to the lateral biplanar open-wedge and the uniplanar DFO techniques. The horizontal cuts of the biplane DFO techniques are positioned behind the trochle... | yes |
22,802,321 | Does social influence on clinical outcomes of patients with ovarian cancer? | {
"contexts": [
"Previous research has demonstrated relationships of social support with disease-related biomarkers in patients with ovarian cancer. However, the clinical relevance of these findings to patient outcomes has not been established. This prospective study examined how social support relates to long-te... | Social attachment is associated with a survival advantage for patients with ovarian cancer. Clinical implications include the importance of screening for deficits in the social environment and consideration of support activities during adjuvant treatment. | yes |
22,768,196 | Is high interstitial fluid pressure associated with tumor-line specific vascular abnormalities in human melanoma xenografts? | {
"contexts": [
"Interstitial fluid pressure (IFP) is highly elevated in many solid tumors. High IFP has been associated with low radiocurability and high metastatic frequency in human melanoma xenografts and with poor survival after radiation therapy in cervical cancer patients. Abnormalities in tumor vascular n... | High IFP in A-07-GFP and R-18-GFP human melanoma xenografts was primarily a consequence of high blood flow resistance caused by tumor-line specific vascular abnormalities. | yes |
22,771,697 | Are thyroid hormones involved in 5'-nucleotidase modulation in soluble fraction of cardiac tissue? | {
"contexts": [
"To investigate the role of TH (thyroid hormones) in 5'-nucleotidase activity and expression in cardiac soluble fraction (SF).",
"Male Wistar rats received daily injections of T4 (10, 25 or 50 μg T4/100g body weight) for 14 days to develop a hyperthyroidism condition. Thyroidectomy was perform... | Taken together, these data reveal that TH can influence adenosine production by modulating 5'-nucleotidase activity and expression, which may contribute to the cardioprotective effect and the maintenance of cardiac function under TH privation. | yes |
22,771,693 | Does nicotine-induced activation of soluble adenylyl cyclase participate in ion transport regulation in mouse tracheal epithelium? | {
"contexts": [
"Functional nicotinic acetylcholine receptors (nAChR) have been identified in airway epithelia and their location in the apical and basolateral membrane makes them targets for acetylcholine released from neuronal and non-neuronal sources. One function of nAChR in airway epithelia is their involvem... | This study indicates that nicotine binding to nAChR in mouse tracheal epithelium activates transepithelial ion transport involving adenylyl cyclase activity. This might be important for novel therapeutic strategies targeting epithelial ion transport mediated by the non-neuronal cholinergic system. | yes |
22,771,321 | Does acid sphingomyelinase deficiency contribute to resistance of scleroderma fibroblasts to Fas-mediated apoptosis? | {
"contexts": [
"Scleroderma (SSc) is characterized by excess production and deposition of extracellular matrix (ECM) proteins. Activated fibroblasts play a key role in fibrosis in SSc and are resistant to Fas-mediated apoptosis. Acid sphingomyelinase (ASMase), a major sphingolipid enzyme, plays an important role... | In conclusion, this study suggests that ASMase deficiency promotes apoptosis resistance and contributes to activation of profibrotic signaling in SSc fibroblasts. | yes |
22,797,512 | Is age-related cataract associated with type 2 diabetes and statin use? | {
"contexts": [
"Diabetes has been shown to be a risk factor for age-related (AR) cataract. As statins (HMG-CoA reductase inhibitors) are now commonly prescribed for patients with type 2 diabetes, their impact on AR cataract prevalence should be considered. This study determines associations between AR cataract, ... | In this population, statin use was substantially higher in patients with type 2 diabetes and was associated with AR cataracts. Further long-term study is warranted to recommend monitoring of crystalline lenses in patients with type 2 diabetes benefiting from statins. | yes |
22,797,511 | Is myopia progression in Chinese children slower in summer than in winter? | {
"contexts": [
"To characterize seasonal variation in the myopic progression of Chinese children.",
"Myopia progression data are presented for a total of 85 Chinese children, aged 6 to 12 years, with baseline myopia of -0.75 D to -3.50 D sphere and astigmatism ≤-1.50 D, who wore traditional single-vision spe... | Myopia progression in summer months was approximately 60% of that seen in winter, and axial elongation was likewise significantly less in summer. It is unclear whether more time spent outdoors in summer vs. winter is a contributing factor, or the difference in progression rates is a result of "seasonal" variations in t... | yes |
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