pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
22,792,164 | Is 3q26 amplification an effective negative triage test for LSIL : a historical prospective study? | {
"contexts": [
"Women with low grade squamous intraepithelial lesions (LSIL) at cervical cancer screening are currently referred for further diagnostic work up despite 80% having no precancerous lesion. The primary purpose of this study is to measure the test characteristics of 3q26 chromosome gain (3q26 gain) a... | 3q26 gain demonstrates high sensitivity and NPV as a negative triage test for women with LSIL, allowing possible guideline changes to routine surveillance instead of immediate colposcopy. Prospective studies are ongoing to establish the sensitivity, specificity, PPV and NPV of 3q26 gain for LSIL over time. | yes |
22,800,451 | Does [ Wnt3a induce epithelial-mesenchymal transition of lens epithelial cells ]? | {
"contexts": [
"To investigate the effects of Wnt3a on epithelial-mesenchymal transition (EMT) in human lens epithelial cells and its molecular mechanisms.",
"Experimental research. The Wnt3a expression vector was designed and transiently transfected into SRA0104 cells and the PcDNA-HA expression vector was ... | Wnt3a activates Wnt/β-catenin signaling pathway, induces EMT in lens epithelial cells and then increases mobility and migration of lens epithelial cells. | yes |
22,797,142 | Does aerosolized perfluorocarbon improve gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndrome? | {
"contexts": [
"Aerosolized perfluorocarbon (PFC) has been proposed as an alternative method of PFC administration; however, the efficacy of aerosolized PFC in a preterm animal model has not yet been demonstrated.",
"Twelve preterm lambs were randomized to two groups: a perfluorodecalin (PFD) aerosol group (... | Aerosolized PFD improves pulmonary function in preterm lambs and should be further investigated as an alternative mode of PFC administration. | yes |
22,791,300 | Does electroacupuncture improve orthostatic tolerance in healthy individuals via improving cardiac function and activating the sympathetic system? | {
"contexts": [
"Orthostatic intolerance (OI) is a common clinical problem; however, effective and applicable clinical prevention/treatment is limited. The aim of this study was to investigate whether electroacupuncture (EA) is a novel effective treatment in attenuating OI in healthy individuals.",
"This stud... | Electroacupuncture at PC-6 is effective in improving orthostatic tolerance. Cardiac function improvement and sympathetic activation are responsible for the improved orthostatic tolerance after EA. EA represents a novel intervention against OI. | yes |
22,781,025 | Is lipid accumulation product a powerful index for recognizing insulin resistance in non-diabetic individuals? | {
"contexts": [
"Lipid accumulation product (LAP) is an index, which combines waist circumference (WC) and triglyceride (TG) reflecting lipid accumulation. The aims of the study were to explore the relationship between LAP and insulin resistance (IR) and to assess whether LAP was superior to WC and body mass inde... | LAP is closely associated with HOMA-IR and is a powerful index that outperforms BMI and WC in identifying IR in non-diabetic individuals. | yes |
22,768,164 | Do extracellular IgC2 constant domains of CEACAMs mediate PI3K sensitivity during uptake of pathogens? | {
"contexts": [
"Several pathogenic bacteria utilize receptors of the CEACAM family to attach to human cells. Binding to different members of this receptor family can result in uptake of the bacteria. Uptake of Neisseria gonorrhoeae, a gram-negative human pathogen, via CEACAMs found on epithelial cells, such as C... | Our results provide novel mechanistic insight into CEACAM1-mediated endocytosis and suggest that epithelial CEACAMs associate in cis with other membrane receptor(s) via their extracellular domains to trigger bacterial uptake in a PI3K-dependent manner. | yes |
22,768,165 | Does the HyVac4 subunit vaccine efficiently boost BCG-primed anti-mycobacterial protective immunity? | {
"contexts": [
"The current vaccine against tuberculosis (TB), BCG, has failed to control TB worldwide and the protective efficacy is moreover limited to 10-15 years. A vaccine that could efficiently boost a BCG-induced immune response and thus prolong protective immunity would therefore have a significant impac... | H4-IC31® can efficiently boost BCG-primed immunity leading to an increased protective anti-M.tb immune response dominated by IFNγ/TNFα/IL-2 or TNFα/IL2 producing CD4 T cells. H4 in the CD4 T cell inducing adjuvant IC31® is presently in clinical trials. | yes |
22,768,168 | Is a retinoblastoma orthologue a major regulator of S-phase , mitotic , and developmental gene expression in Dictyostelium? | {
"contexts": [
"The retinoblastoma tumour suppressor, Rb, has two major functions. First, it represses genes whose products are required for S-phase entry and progression thus stabilizing cells in G1. Second, Rb interacts with factors that induce cell-cycle exit and terminal differentiation. Dictyostelium lacks ... | Like its mammalian counterpart Dictyostelium, RblA plays a dual role, regulating cell-cycle progression and transcriptional events leading to terminal differentiation. In the absence of a G1 phase, however, RblA functions in late G2 controlling the expression of both S-phase and mitotic genes. | yes |
22,792,392 | Does the transcription factor c-Jun protect against liver damage following activated β-Catenin signaling? | {
"contexts": [
"The Wnt/β-Catenin signaling pathway is central for liver functions and frequently deregulated in hepatocellular carcinoma (HCC). Analysis of the early phenotypes and molecular events following β-Catenin activation is therefore essential for better understanding HCC pathogenesis. The AP-1 transcri... | These data indicate that c-Jun is not a primary target of β-Catenin signaling in the liver, but rather protects against liver damage, which in turn may promote liver tumorigenesis. | yes |
22,770,232 | Are the plastid-localized pfkB-type carbohydrate kinases FRUCTOKINASE-LIKE 1 and 2 essential for growth and development of Arabidopsis thaliana? | {
"contexts": [
"Transcription of plastid-encoded genes requires two different DNA-dependent RNA polymerases, a nuclear-encoded polymerase (NEP) and plastid-encoded polymerase (PEP). Recent studies identified two related pfkB-type carbohydrate kinases, named FRUCTOKINASE-LIKE PROTEIN (FLN1 and FLN2), as component... | Our results demonstrate that each FLN protein contributes to wild type growth, and acting additively are absolutely essential for plant growth and development. | yes |
22,777,518 | Does red blood cell transfusion affect microdialysis-assessed interstitial lactate/pyruvate ratio in critically ill patients with late sepsis? | {
"contexts": [
"The aim of this study was to explore the effect of red blood cell (RBC) transfusion on microdialysis-assessed interstitial fluid metabolic parameters in septic patients.",
"We conducted a retrospective study of 37 patients with severe sepsis/septic shock requiring transfusion of one to two RB... | Tissue oxygenation is affected by RBC transfusion in critically ill septic patients. Monitoring of tissue LP ratio by microdialysis may represent a useful method for individual clinical management. | yes |
22,781,359 | Does [ PreC/C gene-targeting RNA interference suppress hepatitis B virus replication and expression in human hepatoma cells ]? | {
"contexts": [
"To explore the antiviral efficacy of small interfering RNAs (siRNAs)/shRNA targeting preC/C of HBV in human hepatoma cells Huh-7 and HepG2.2.15 cells.",
"Three 21 nucleotide(nt) siRNAs for treating HBV preC/C gene were designed and synthesized according to the HBV genome in GenBank accession ... | For the first time it has been found that RNAi induced by siRNA/shRNA targeting HBV preC/C gene is effective and specific in inhibiting HBV replication and expression in human hepatoma cells Huh-7 and HepG2.2.15 cells. Our data suggest that RNAi may provide an effective, viable approach in gene therapy to treating majo... | yes |
22,802,824 | Is the hyperdense posterior cerebral artery sign in CT related to larger ischemic lesion volume? | {
"contexts": [
"Hyperdensity of the middle cerebral artery (MCA) on unenhanced CT is a recognized sign associated with brain's early ischemia. The number of studies which showed a hyperdense posterior cerebral artery (HPCA) sign in posterior circulation infarct is relatively small. We investigated the prevalence... | The HPCA may be considered as an additional marker of early brain infarct, especially with large lesion volume. | yes |
22,778,149 | Is expression of PaNAC01 , a Picea abies CUP-SHAPED COTYLEDON orthologue , regulated by polar auxin transport and associated with differentiation of the shoot apical meristem and formation of separated cotyledons? | {
"contexts": [
"During embryo development in most gymnosperms, the establishment of the shoot apical meristem (SAM) occurs concomitantly with the formation of a crown of cotyledons surrounding the SAM. It has previously been shown that the differentiation of cotyledons in somatic embryos of Picea abies is depend... | The results show that CUC-like genes with distinct signature motifs existed before the separation of angiosperms and gymnosperms approx. 300 million years ago, and suggest a conserved function between PaNAC01 and CUC1/CUC2. | yes |
22,775,473 | Does pranic meditation affect phagocyte functions and hormonal levels of recent practitioners? | {
"contexts": [
"Despite the recognized importance of phagocytes in the maintenance and recovery of health, the influence of meditation on their functions is not properly established. This investigation aimed at evaluating the influence of pranic meditation on the functions of phagocytes, and on the levels of hor... | This is the first study to show that a short program of pranic meditation practice was able to upregulate the function and metabolism of phagocytes, in parallel with the reduction of the plasma levels of corticotrophin. The results of this study point to a possible causal effect between these events, and indicate that ... | yes |
22,776,089 | Does complement receptor-3 negatively regulate the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin? | {
"contexts": [
"Intact myelin, which normally surrounds axons, breaks down in Wallerian degeneration following axonal injury and during neurodegenerative diseases such as multiple sclerosis. Clearance of degenerated myelin by phagocytosis is essential since myelin impedes repair and exacerbates damage. CR3 (comp... | CR3 both activates and downregulates myelin phagocytosis at the same time. Activation was previously documented. We presently demonstrate that downregulation is mediated through Syk, which advances the inactive phosphorylated state of cofilin. Self-negative control of phagocytosis by the phagocytic receptor can be usef... | yes |
22,776,081 | Is red blood cell transfusion associated with troponin release after elective off-pump coronary artery bypass surgery? | {
"contexts": [
"Increased troponin levels after coronary artery bypass surgery are associated with increased risk of early and late mortality. We hypothesized that perioperative blood transfusion is associated with increased postoperative troponin release.",
"Complete data on perioperative blood transfusion ... | Red blood cell transfusion is associated with increased troponin I release after elective off-pump coronary artery bypass graft surgery independently of hemoglobin and hematocrit nadirs. These findings suggest that prevention of major bleeding requiring blood transfusion may be cardioprotective during coronary surgery.... | yes |
22,799,511 | Does systematic exposure to recreation centers increase use by Latino families with young children? | {
"contexts": [
"Living near community recreation centers (CRC) is associated with increases in adolescent and adult physical activity, but the efficacy of efforts to increase use among Latino parents and young children is unknown. We hypothesized that Latino parent-child dyads with exposure to a CRC through cult... | CRCs that develop culturally tailored programs that invite Latino families inside can increase sustained CRC use for physical activity in this population at heightened risk for childhood obesity. | yes |
22,772,753 | Does caveolin-1 play a critical role in the differentiation of monocytes into macrophages? | {
"contexts": [
"Monocyte to macrophage differentiation is an essential step in atherogenesis. The structure protein of caveolae, caveolin-1, is increased in primary monocytes after its adhesion to endothelium. We explore the hypothesis that caveolin-1 plays a role in monocyte differentiation to macrophages.",
... | Caveolin-1 promotes monocyte to macrophage differentiation through the regulation of EGR-1 transcriptional activity, suggesting that phagocytic caveolin-1 may be critical for atherogenesis. | yes |
22,772,757 | Is vascular smooth muscle cell Smad4 gene important for mouse vascular development? | {
"contexts": [
"Smad4 is a central mediator of transforming growth factor-β/bone morphogenetic protein signaling that controls numerous developmental processes as well as homeostasis in the adult. The present studies sought to understand the function of Smad4 expressed in vascular smooth muscle cells (VSMC) in v... | SMC-specific deletion of Smad4 results in vascular defects that lead to embryonic lethality in mice, which may be attributed to decreased VSMC differentiation, proliferation, migration, as well as cell attachment and spreading. The transforming growth factor-β signaling pathway contributes to VSMC differentiation and f... | yes |
22,787,065 | Is emergency medical service hospital prenotification associated with improved evaluation and treatment of acute ischemic stroke? | {
"contexts": [
"The benefits of intravenous tissue-plasminogen activator (tPA) in acute ischemic stroke are time-dependent. Emergency medical services (EMS) hospital prenotification of an incoming patient with potential stroke may provide a means of reducing evaluation and treatment times and improving treatment... | EMS hospital prenotification is associated with improved evaluation, timelier stroke treatment, and more eligible patients treated with tPA. These results support the need for initiatives targeted at increasing EMS prenotification rates as a mechanism from improving quality of care and outcomes in stroke. | yes |
22,777,604 | Does the development of an assessment and intervention fall guide for older hospitalized adults with cardiac conditions? | {
"contexts": [
"Older patients with chronic cardiac conditions are more vulnerable to falls and injuries. Cardiovascular conditions, prevalent in older people, are also the frequent cause of potentially harmful fall injuries among this group. The need to identify the fall risk-related factors that cluster with a... | The project demonstrated an evidence-informed process that was used to design and implement this assessment tool and a change in nursing practice. It also provided information about the prevalence of cardiac-related risk fall factors that were utilized in the development of this Assessment and Intervention Falls Guide ... | yes |
22,777,108 | Is tea consumption inversely associated with weight status and other markers for metabolic syndrome in US adults? | {
"contexts": [
"Tea (Camellia sinensis) is a widely consumed beverage, and laboratory and some intervention studies have indicated the potential health benefits of hot tea. The present study examines the association between tea consumption (evaluating hot and iced tea independently) and markers for metabolic syn... | These cross-sectional results support growing laboratory data, which demonstrate the negative association of hot tea intake with markers of MetS. | yes |
22,780,967 | Do [ NF-κB subunits regulate maspin expression in prostate cancer cells in vitro ]? | {
"contexts": [
"To explore how NF-κB family members regulate maspin expression in prostate cancer cells.",
"The expression of NF-κB subunits and maspin was detected by Western blot analysis in prostate cancer DU145, PC-3, and LNCaP cell lines. RNA interference was performed to analyze whether RelB- or RelA-d... | The classical and alternative NF-κB activitions are sustained in androgen-independent prostate cancer cell lines. The expressions of RelB and maspin are inversely correlated in these cancer cells. The expression of RelB negatively regulates the endogenous expression of maspin, then interferes the cell survival. RelA is... | yes |
22,785,446 | Are levels of circulating endothelial cells and colony-forming units influenced by age and dyslipidemia? | {
"contexts": [
"The balance between endothelial injury and repair in childhood is poorly understood. We examined this relationship in healthy children, in adults, and in children with familial hypercholesterolemia (FH).",
"Circulating endothelial cells (CECs) were measured as a marker of vascular injury, wit... | Levels of CECs increase and CFUs decrease with age. In childhood, before the onset of clinically detectable cardiovascular dysfunction, children with a major risk factor for atherosclerotic disease have levels of these indexes of vascular injury and repair approaching those seen in adults. | yes |
22,782,139 | Are respiratory therapy organizational changes associated with increased respiratory care utilization? | {
"contexts": [
"The effect of the respiratory therapist (RT)/patient ratio and RT organizational factors on respiratory resource utilization is unknown. We describe the impact of a multi-component intervention that called for an increase in RT/patient ratio (1:14 to 1:10), improved RT orientation, and formation ... | A multi-component intervention, including an increase in RT/patient ratio, improved RT orientation, and establishment of a core staffing model, was associated with increased respiratory resource utilization and evidence-based practice, specifically BALs and SBTs. | yes |
22,799,377 | Do gold nanoparticles induce apoptosis in MCF-7 human breast cancer cells? | {
"contexts": [
"Gold nanoparticles have recently been investigated with respect to biocompatibility according to their interactions with cells. The purpose of this study was to examine cytotoxicity and apoptosis induction by well-characterized gold nanoparticles in human breast epithelial MCF-7 cells.",
"Apo... | To the best of our knowledge this is the first report showing that gold nanoparticles induce apoptosis in MCF-7 cells via p53, bax/bcl-2 and caspase pathways. | yes |
22,790,431 | Does eye feature in three Danish patients with multisystemic smooth muscle dysfunction syndrome? | {
"contexts": [
"A de novo mutation of the ACTA2 gene encoding the smooth muscle cell α-actin has been established in patients with multisystemic smooth muscle dysfunction syndrome associated with patent ductus arteriosus and mydriasis present at birth.",
"To describe the structural ocular findings in three D... | Congenital mydriasis is an extremely rare pupil anomaly and is the feature for the early diagnosis of this new syndrome. The ophthalmologist should act in close collaboration with other specialists owing to the risk of aortic and cerebrovascular diseases and other complications associated with this disorder. | yes |
22,793,020 | Is the correlation between the hyperacusis questionnaire and uncomfortable loudness levels dependent on emotional exhaustion? | {
"contexts": [
"To validate the hyperacusis questionnaire (HQ) in different strata of emotional exhaustion (EE).",
"HQ-scores and uncomfortable loudness levels (ULLs) were assessed in 348 individuals (140 men and 208 women) with low, intermediate, and high EE-levels.",
"Four individuals (1.1%) met the cr... | The results emphasize the need to take other factors, such as emotional exhaustion (long-term stress), into consideration when assessing hyperacusis with a questionnaire. | yes |
22,787,135 | Does cardiotrophin-1 induce sarcoplasmic reticulum Ca ( 2+ ) leak and arrhythmogenesis in adult rat ventricular myocytes? | {
"contexts": [
"Plasma levels of cardiotrophin-1 (CT-1) are elevated in several cardiovascular diseases and are correlated with the severity of the pathology. However, the mechanisms by which this inflammatory cytokine participates in the pathology of the heart are not completely understood. It is well establish... | Our findings provide evidence that cardiomyocytes treated with CT-1 present high spontaneous Ca(2+) release during diastole, a mechanism linked to arrhythmogenicity in the pathologic heart. | yes |
22,788,833 | Do cisplatin and ultra-violet-C synergistically down-regulate receptor tyrosine kinases in human colorectal cancer cells? | {
"contexts": [
"Platinum-containing anti-cancer drugs such as cisplatin are widely used for patients with various types of cancers, however, resistance to cisplatin is observed in some cases. Whereas we have recently reported that high dose UV-C (200 J/m²) induces colorectal cancer cell proliferation by desensit... | The combination of low dose cisplatin and low dose UV-C synergistically exerted anti-cancer effect by down-regulating RTK, such as EGFR and HER2. These findings may provide a novel strategy for the treatment of patients with colorectal cancer. | yes |
22,786,786 | Is carbohydrate antigen 19-9 a prognostic and predictive biomarker in patients with advanced pancreatic cancer who receive gemcitabine-containing chemotherapy : a pooled analysis of 6 prospective trials? | {
"contexts": [
"Carbohydrate antigen 19-9 (CA19-9) is a widely used biomarker in pancreatic cancer. There is no consensus on the interpretation of the change in CA19-9 serum levels and its role in the clinical management of patients with pancreatic cancer.",
"Individual patient data from 6 prospective trials... | In patients who have advanced pancreatic cancer treated with gemcitabine-containing regimens baseline CA19-9 is prognostic for outcome. A decline in CA19-9 after the second cycle of chemotherapy is not predictive of improved mOS or mTTP; thus, CA19-9 decline is not a useful surrogate endpoint in clinical trials. Clinic... | yes |
22,778,558 | Does a dietary supplement containing chlorophytum borivilianum and velvet bean improve sleep quality in men and women? | {
"contexts": [
"Impaired sleep quality is commonplace within industrialized societies, as evidenced by the increasing number of prescription sleep aids available. Certain herbal preparations have been suggested to provide a natural benefit to sleep; however, limited controlled data are available documenting this... | An investigational dietary supplement containing the active ingredients Chlorophytum borivilianum and Velvet bean improves sleep quality in men and women. Additional placebo controlled trials are needed to corroborate these findings in individuals with self-reported sleeping difficulty. | yes |
22,788,670 | Are stallion spermatozoa selected by single layer centrifugation capable of fertilization after storage for up to 96 h at 6°C prior to artificial insemination? | {
"contexts": [
"One of the challenges faced by equine breeders is ensuring delivery of good quality semen doses for artificial insemination when the mare is due to ovulate. Single Layer Centrifugation (SLC) has been shown to select morphologically normal spermatozoa with intact chromatin and good progressive mot... | SLC-selected stallion spermatozoa stored for up to 96 h are capable of fertilization. | yes |
22,789,984 | Is the prostaglandin E2 receptor , EP2 , upregulated in the dorsal root ganglion after painful cervical facet joint injury in the rat? | {
"contexts": [
"This study implemented immunohistochemistry to assay prostaglandin E2 (PGE2) receptor EP2 expression in the dorsal root ganglion (DRG) of rats after painful cervical facet joint injury.",
"To identify if inflammatory cascades are induced in association with cervical facet joint distraction-in... | Painful cervical facet joint distraction induces an immediate and sustained increase of EP2 expression in the DRG, implicating peripheral inflammation in the initiation and maintenance of facet joint pain. The transient increase in neuronal EP2 suggests, as in other painful joint conditions, that after joint injury non... | yes |
22,800,560 | Is histone H3K79 methyltransferase Dot1L directly activated by thyroid hormone receptor during Xenopus metamorphosis? | {
"contexts": [
"Thyroid hormone (T3) is important for adult organ function and vertebrate development. Amphibian metamorphosis is totally dependent on T3 and offers a unique opportunity to study how T3 controls postembryonic development in vertebrates. Earlier studies have demonstrated that TR mediates the metam... | Our findings suggest that TR activates Dot1L, which in turn participates in metamorphosis through a positive feedback to enhance H3K79 methylation and gene activation by liganded TR. | yes |
22,802,553 | Does planning estimate for the provision of core mental health services in Queensland 2007 to 2017? | {
"contexts": [
"To derive planning estimates for the provision of public mental health services in Queensland 2007-2017.",
"We used a five-step approach that involved: (i) estimating the prevalence and severity of mental disorders in Queensland, and the number of people at each level of severity treated by h... | The recommended targets pointed to specific areas for priority in Queensland, notably the need for additional acute inpatient services for older persons and expansion of clinical ambulatory care, residential rehabilitation and supported accommodation services. The development of nationally agreed planning targets for p... | yes |
22,790,188 | Is long duration of radiofrequency energy delivery an independent predictor of clinical recurrence after catheter ablation of atrial fibrillation : over 500 cases experience? | {
"contexts": [
"Although radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) is an effective rhythm control strategy, there is a substantial amount of recurrence. We explored the predictors of AF recurrence after RFCA with consistent ablation strategy.",
"This study included 575 patients (77... | In this single center consistent study of over 500 cases of AF ablation, patients with AF recurrence had a larger atrium, longer ablation time, and a higher chance of early recurrence than those remained in sinus rhythm. Inadvertent, long duration of ablation was an independent predictor of worse clinical outcomes afte... | yes |
22,779,167 | Does [ research on relationship between genetic differentiation and chemical variation of Cinnamomum migao ]? | {
"contexts": [
"To study the relationship between the genetic diversity and chemical variation of Cinnamomum migao.",
"ISSR marker technique was used to research the genetic structure of 9 population, GC-MS was used to analyze the main ingredients of the volatile oil in C. migao.",
"The analysis on the m... | The genetic diversity of C. migao was relatively high at the population levels, while it is low within the population levels, the relationship between chemical variation and genetic diversity was not obvious, that may indicate that other factors causes the chemical variation of C. migao. | yes |
22,800,687 | Does sca-1 knockout impair myocardial and cardiac progenitor cell function? | {
"contexts": [
"Cardiac progenitor cells are important for maintenance of myocardial structure and function, but molecular mechanisms governing these progenitor cells remain obscure and require elucidation to enhance regenerative therapeutic approaches.",
"To understand consequences of stem cell antigen-1 (S... | Genetic deletion of Sca-1 causes primary cardiac defects in myocardial contractility and repair consistent with impairment of resident cardiac progenitor cell proliferative capacity associated with altered canonical Wnt signaling. | yes |
22,775,576 | Do institutional peer support mediates the impact of physical declines on depressive symptoms of nursing home residents? | {
"contexts": [
"This paper tests the mediating effect of institutional peer support on the relationship between physical declines and depressive symptoms among nursing home residents.",
"As the number of older adults living in nursing homes increases, peer support received from other residents in the institu... | Findings of this study reveal that institutional peer support positively contributes to the psychological well-being of nursing home residents. | yes |
22,776,617 | Does inhibition of p38 MAPK reduce loss of primary sensory neurons after nerve transection? | {
"contexts": [
"p38 member of mitogen-activated protein kinase (MAPK) family has been shown to participate in neuropathic pain and axonal regeneration after nerve injury. However, its role in axotomy-induced neuronal apoptosis remains unclear. This study was aimed to examine p38 phosphorylation in the dorsal ro... | These data suggest the role of p38 in sensory neuronal loss after nerve transection. Future studies should be done to confirm the apoptotic role of p38 in this condition. | yes |
22,804,613 | Is loss of succinate dehydrogenase subunit B ( SDHB ) expression limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours : a comprehensive genotype-phenotype correlation study? | {
"contexts": [
"Gastrointestinal stromal tumours (GISTs) typically harbour KIT or PDGFRA mutations; 15% of adult GISTs and >90% in children lack such mutations ('wild-type' GISTs). Paediatric and occasional adult GISTs show similar, distinctive features: multinodular architecture and epithelioid morphology, indo... | SDHB-deficient GISTs are wild-type gastric tumours with distinctive histology. Immunohistochemistry for SDHB can be used to confirm the diagnosis of this tumour class. SDHB expression is retained in all GISTs with KIT and PDGFRA mutations. | yes |
22,769,411 | Are important technical parameters presented in reports of intraoral digital radiography in endodontic treatment : recommendations for future studies? | {
"contexts": [
"The aims of this study were to review the literature on intraoral digital radiography in endodontic treatment with focus on technical parameters and to propose recommendations for improving the quality of reports in future publications.",
"Two electronic databases were searched. Titles and ab... | The methodologic quality of future publications must be improved to permit replication of studies and comparison of results between studies in dental digital radiography. Our recommendations can improve the quality of studies on diagnostic accuracy. | no |
22,766,656 | Is poor health , but not fracture and fall risk , associated with nonattendance at bone mineral density screening? | {
"contexts": [
"Bone mineral density screening identifies women at risk for fracture. Nonattendance at screening is associated with subsequent hip fracture. Determining reasons for nonattendance may help in the designing of methods to improve screening.",
"We hypothesize that nonattenders may report poorer h... | Failure to attend osteoporosis screening is associated with significant health problems and poor self-rated health. Improving point of care access may increase the amount of osteoporosis screening among women with multiple comorbidities. | yes |
22,783,587 | Is serum uric acid level an indicator of total cholesterol and low density lipoprotein cholesterol in men below 45 years in age but not older males? | {
"contexts": [
"Uric acid, the final product of purine catabolism, has been associated with dyslipidemia, most importantly hypertriglyceridemia. But studies on the relation between uric acid and lipid parameters in the Indian population have been minimal.",
"Relation between serum uric acid and serum lipids ... | Thus, serum uric acid levels in the normal range might be a good indicator of the level of triglycerides and very low density lipoprotein cholesterol in men encompassing a wide age range but of total cholesterol and low density lipoprotein cholesterol only in men less than 45 years in age. | yes |
22,783,586 | Are elevated serum chemerin levels associated with the presence of coronary artery disease in patients with type 2 diabetes? | {
"contexts": [
"Coronary artery disease (CAD) is a major vascular complication of type 2 diabetes mellitus (T2DM) and reveals high mortality. Serum levels of chemerin have been suggested to be involved in glucose and lipid metabolism and associated with several cardiovascular factors. The aim of this study is to... | There is an independent association between serum levels of chemerin and the presence of CAD in patients with T2DM. | yes |
22,783,588 | Is the inhibition of the pemetrexed-activated MAPK pathway via sorafenib involved in the synergistic mechanism of sorafenib subsequent potentiation of pemetrexed cytotoxicity in EGFR TKI-resistant cell lines? | {
"contexts": [
"The effect of combined administration of the multi-targeted receptor tyrosine kinase (RTK) inhibitor (Sorafenib) and chemotherapy (Pemetrexed) is still unknown. The cytotoxicity, the optimal combined modality, and the mechanisms underlying the cytotoxic synergism between sorafenib and pemetrexed ... | The sequence of pemetrexed followed by sorafenib had a synergistic effect and an advantage over other sequences in EGFR TKI-resistant NSCLC cell lines. The synergistic mechanism was due to sorafenib subsequently inhibiting the pemetrexed-activated MAPK signaling pathway. The results may provide molecular evidence to su... | yes |
22,782,573 | Is voriconazole delivered from antifungal-loaded bone cement? | {
"contexts": [
"Local delivery of antifungals is an important modality in managing orthopaedic fungal infection. Voriconazole is a powder antifungal suitable for addition to bone cement that is released from bone cement but the mechanical properties of antimicrobial-loaded bone cement (ALBC) made with voriconazo... | Voriconazole release from ALBC increases with dose and is bioactive. Loss in compressive strength is greater after elution and with higher dose. | yes |
22,785,138 | Is efficacy of ezetimibe associated with gender and baseline lipid levels in patients with type 2 diabetes? | {
"contexts": [
"The combination of ezetimibe and a statin provides greater LDL-C reduction by inhibiting both intestinal cholesterol absorption and endogenous production of cholesterol. The present study was designed to examine the influence of ageing, gender, BMI, levels of LDL-C, and HbA1c on the response to e... | Addition of ezetimibe to ongoing statin therapy was effective in patients with type 2 diabetes. Male sex and baseline LDL-C levels are independent predictors of marked TC reduction by ezetimibe treatment. | yes |
22,771,318 | Does shilajit attenuate behavioral symptoms of chronic fatigue syndrome by modulating the hypothalamic-pituitary-adrenal axis and mitochondrial bioenergetics in rats? | {
"contexts": [
"Shilajit has been used as a rejuvenator for ages in Indian ancient traditional medicine and has been validated for a number of pharmacological activities.",
"The effect of processed shilajit which was standardized to dibenzo-α-pyrones (DBPs;0.43% w/w), DBP-chromoproteins (DCPs; 20.45% w/w) an... | The results indicate that shilajit mitigates the effects of CFS in this model possibly through the modulation of HPA axis and preservation of mitochondrial function and integrity. The reversal of CFS-induced behavioral symptoms and mitochondrial bioenergetics by shilajit indicates mitochondria as a potential target for... | yes |
22,771,700 | Does trypsin inhibit lipopolysaccharide signaling in macrophages via toll-like receptor 4 accessory molecules? | {
"contexts": [
"To examine the role of trypsin in the immune response of macrophages and to determine whether protease-activated receptors (PARs) are involved in the effects of trypsin.",
"We used RAW264.7 cells and peritoneal macrophages isolated from C57BL/6 wild-type mice, PAR2 knockout mice, and ddY mice... | Trypsin inhibited LPS signaling PAR-independently via degradation of TLR4 accessory molecules. This observation provides a better understanding of the complicated immune response in acute pancreatitis. | yes |
22,790,990 | Is fibulin-5 protein reduced in the lung of patients with spontaneous pneumothorax who are under 25 years old? | {
"contexts": [
"To clarify whether fibulins-5 is associated with primary spontaneous pneumothorax (PSP) in young PSP patients.",
"Forty-six surgically resected, fresh lung specimens were used. Patients were divided into 3 groups: younger than 25 years with pneumothorax (group Y), 25 years or older with pneum... | We showed that fibulin-5 is reduced in patients with PSP who are younger than 25 years. | yes |
22,797,673 | Do increased ferritin concentrations correlate with insulin resistance in female type 2 diabetic patients? | {
"contexts": [
"Iron overload identified by elevated ferritin concentrations has been implicated in risks of altered glucose metabolism and diabetic complications. The relationship between ferritin and insulin resistance in different gender and ethnicities remains uncertain; this study aimed to investigate it us... | Iron overload, which produces elevated levels of ferritin, may augment insulin resistance in female but not in male type 2 diabetes. Longitudinal studies are warranted to establish relationships between iron stores and diabetes development in men and women of different ethnicities. | yes |
22,776,223 | Is routine drainage necessary after laparoscopic gastric bypass? | {
"contexts": [
"Routine intra-abdominal drainage has been recommended for detecting surgical complications, such as anastomotic leaks or intra-abdominal hemorrhage, after laparoscopic gastric bypass for morbid obesity. The aim of this study was to determine whether routine drainage after laparoscopic gastric byp... | Routine abdominal drainage is not necessary after a successful laparoscopic gastric bypass for morbidly obese patients. Drainage omission may contribute to a quicker recovery without additional surgical complications. | no |
22,785,499 | Is residual viability a predictor of the perfusion enhancement obtained with the cell therapy of chronic myocardial infarction : a pilot multimodal imaging study? | {
"contexts": [
"Up to now, there has been limited investigation into cell therapy in the chronic phase of severe myocardial infarction (MI), and many questions remain concerning the contribution of the engrafted cells and especially their impact on the reperfusion of MI areas, when assessed by objective quantita... | Perfusion enhancement, obtained with BMNCs in areas of chronic MI, might require an intermediate level of viability documented with FDG-PET and MRI and that totally necrotic MI seems refractory to this cell therapy technique. | yes |
22,772,320 | Are th1 and Th17 cell subpopulations enriched in the peripheral blood of patients with systemic juvenile idiopathic arthritis? | {
"contexts": [
"The role of the adaptive immune system has not been explored in detail compared with the innate immune system in systemic JIA (sJIA) pathogenesis. The aim of this study was to examine the phenotype of circulating peripheral blood CD4(+) T-cell subpopulations in a cross-sectional study of sJIA pat... | This study is the first to describe significantly higher proportions of Th1 and Th17 T helper cell subsets in the peripheral blood of sJIA patients. These proinflammatory cells may play a pathogenic role in sJIA. Our data also emphasize the importance of using paediatric age-matched control subjects when evaluating the... | yes |
22,768,113 | Does nOTCH1 signaling promote human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches? | {
"contexts": [
"Leukemia initiating cells (LIC) contribute to therapeutic resistance through acquisition of mutations in signaling pathways, such as NOTCH1, that promote self-renewal and survival within supportive niches. Activating mutations in NOTCH1 occur commonly in T cell acute lymphoblastic leukemia (T-ALL... | These results reveal a functional hierarchy within the LIC population based on NOTCH1 activation, which renders LIC susceptible to targeted NOTCH1 inhibition and highlights the utility of NOTCH1 antibody targeting as a key component of malignant stem cell eradication strategies. | yes |
22,768,115 | Is vessel-associated transforming growth factor-beta1 ( TGF-β1 ) increased in the bronchial reticular basement membrane in COPD and normal smokers? | {
"contexts": [
"Transforming growth factor-beta1 (TGF-β1) is a multipotential cytokine with angiogenic activity. There are only limited data about its role in airway remodeling in COPD. We have previously shown that the reticular basement membrane (Rbm) is hypervascular in the airways of current smokers either w... | Vessel-associated TGF-β1 activity is increased in the bronchial Rbm in smokers and especially those with COPD. | yes |
22,768,118 | Is broad resistance to ACCase inhibiting herbicides in a ryegrass population due only to a cysteine to arginine mutation in the target enzyme? | {
"contexts": [
"The design of sustainable weed management strategies requires a good understanding of the mechanisms by which weeds evolve resistance to herbicides. Here we have conducted a study on the mechanism of resistance to ACCase inhibiting herbicides in a Lolium multiflorum population (RG3) from the UK."... | This study establishes the clear and unambiguous importance of the C2088R target site mutation in conferring broad resistance to ten commonly used ACCase inhibiting herbicides. It also demonstrates that low levels "creeping", multigenic, non target site resistance, is not always selected before single gene target site ... | yes |
22,776,677 | Are severity of anxiety and depression related to a higher perception of adverse effects of antiepileptic drugs? | {
"contexts": [
"After reviewing the negative effects of antiepileptic drugs (AEDs) on general health and quality of life, the Commission on Outcome Measurement from the International League Against Epilepsy (ILAE) recommended incorporating reliable and valid tools in clinical essays in order to achieve a more ac... | Adverse effects to AEDs can be related with the presence of psychiatric disorders such as anxiety and depression in patients with epilepsy. | yes |
22,775,407 | Do clonal chromosome anomalies affecting FLI1 mimic inherited thrombocytopenia of the Paris-Trousseau type? | {
"contexts": [
"The thrombocytopenia of the Paris-Trousseau (TCPT) type is a contiguous gene syndrome characterized by mild bleeding tendency, variable thrombocytopenia (THC), abnormal giant alpha-granules in platelets and dysmegakaryopoiesis: it derives from a constitutional deletion of chromosome 11 leading to... | Although our patient presented with nearly all the characteristics of TCPT, her illness was acquired instead of being inherited and the most appropriate diagnosis is that of the unilineage dysplasia 'refractory THC.' This observation suggests that appropriate cytogenetic investigations should be always considered in pa... | yes |
22,787,200 | Is mitochondrial copy number associated with colorectal cancer risk? | {
"contexts": [
"Mitochondria are eukaryotic organelles responsible for energy production. Quantitative changes in human mitochondrial DNA (mtDNA) copy number have been implicated in various cancer types. Data from prospective cohort studies on mtDNA copy number and colorectal cancer risk have been lacking.",
... | This is the first prospectively designed study to show a U-shaped association between the relative mtDNA copy number and risk of colorectal cancer. | yes |
22,789,143 | Is progesterone-dependent regulation of endometrial cannabinoid receptor type 1 ( CB1-R ) expression disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin ( TCDD )? | {
"contexts": [
"To examine the differentiation-related expression of cannabinoid receptor type 1 (CB1-R) messenger RNA (mRNA) and protein in endometrial tissue obtained from women with and without endometriosis and to determine the impact of acute 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on CB1-R gene... | Our studies reveal a role for the anti-inflammatory actions of progesterone in regulating endometrial cannabinoid signaling, which is disrupted in women with endometriosis. We demonstrate for the first time that acute TCDD exposure disrupts cannabinoid signaling in the human endometrium. | yes |
22,795,379 | Does lymph node yield at radical cystectomy predict mortality in node-negative and not node-positive patients? | {
"contexts": [
"To better define the relationship between lymph node count and survival in patients undergoing radical cystectomy for bladder cancer by identifying and controlling for key confounding variables in a large population-based cohort. Considerable controversy remains regarding the correlation between ... | Lymph node count at radical cystectomy is associated with both OS and DSS in patients without nodal metastases. However, in patients with node-positive disease, node count is not an independent predictor of survival suggesting that it is likely a proxy for other patient and provider factors in these individuals. | yes |
22,786,813 | Is the Dyspnoea , Obstruction , Smoking , Exacerbation ( DOSE ) index predictive of mortality in COPD? | {
"contexts": [
"The Dyspnoea, Obstruction, Smoking, Exacerbation (DOSE) index was designed to assess disease severity and for the clinical management of chronic obstructive pulmonary disease (COPD), but has not been evaluated as a prognostic instrument for mortality in a population including primary care patient... | The DOSE index is associated with mortality in COPD patients in primary and secondary care and can be used to assess prognosis in addition to other clinically relevant issues. | yes |
22,773,411 | Is suicide preventable , sometimes? | {
"contexts": [
"The objective was to examine the assumption that suicide is inevitably preventable."
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Humans",
"Mental Disorders",
"Risk Factors",
"Suicide"
]
} | Suicide may not always be avoidable. This does not mean that every effort should not be made to prevent it or vigorously treat illnesses that are often contributory. The assumption, however, may give rise to undue optimism, and unjustified blame when suicides do occur. | yes |
22,797,814 | Do t-cell numbers and antigen-specific T-cell function follow different circadian rhythms? | {
"contexts": [
"Circadian rhythms play an important role in modulating cellular immune responses. The present study was performed to characterise circadian variations in lymphocyte numbers and antigen-specific T-cell functionality in healthy individuals under physiological conditions.",
"Blood leukocyte popu... | Taken together, our data reveal a circadian regulation of T-cell immune responses in the peripheral blood of humans under physiological conditions. This knowledge may be of practical consequence for the timing of blood sampling for functional T-cell assays as well as for immunosuppressive drug intake after organ transp... | yes |
22,776,137 | Does ankle joint mobilization decrease hypersensitivity by activation of peripheral opioid receptors in a mouse model of postoperative pain? | {
"contexts": [
"Investigate whether ankle joint mobilization (AJM) decreases hypersensitivity in the mouse plantar incision (PI) model of postoperative pain as well as to analyze the possible mechanisms involved in this effect.",
"Experiment 1: PI male Swiss mice (25-35 g, N = eight animals per group) were s... | Our results indicate that joint mobilization reduces postoperative pain by activation of the peripheral opioid pathway. However, antihypersensitivity induced by AJM is apparently not limited by the number of opioid-containing leukocytes but by opioid receptors availability in sensory neurons. A better understanding of ... | yes |
22,776,130 | Is polymorphism of angiotensin I-converting enzyme gene related to oral cancer and lymph node metastasis in male betel quid chewers? | {
"contexts": [
"Angiotensin I-converting enzyme (ACE), a type I cell surface zinc metallopeptidase, is differentially expressed in several malignancies and plays a role in tumor cell proliferation, tumor cell migration, angiogenesis, and metastatic behavior. We aimed to investigate the effects of ACE gene (rs179... | Our data suggest that the ACE gene polymorphisms may be associated with increased susceptibility to OPL and oral cancer and lymph node metastasis from oral cancer. | yes |
22,799,292 | Does baicalin induce apoptosis in leukemia HL-60/ADR cells via possible down-regulation of the PI3K/Akt signaling pathway? | {
"contexts": [
"The effect and possible mechanism of traditional Chinese medicine, baicalin, on the PI3K/ Akt signaling pathway in drug-resistant human myeloid leukemia HL-60/ADR cells have been investigated in this current study.",
"HL-60/ADR cells were treated by 20, 40, 80 μmol/L baicalin followed by cell... | We conclude that baicalin may induce HL-60/ADR cell apoptosis through the PI3K/AKT signaling pathway. | yes |
22,776,442 | Does inhalation exposure to smoke from synthetic `` marijuana '' produce potent cannabimimetic effects in mice? | {
"contexts": [
"Use of synthetic \"marijuana\" has increased in recent years, produced adverse effects and prompted the temporary DEA ban of five specific cannabinoid analogs, including JWH-018. The objectives of the current study include determining the chemical content of the herbal product, Buzz, assessing it... | Inhalation exposure to a product containing JWH-018 penetrates into the brain and other organs and produces CB(1) receptor-mediated behavioral pharmacological effects in mice. The increased potency of JWH-018 compared to THC, the variable amount of drug added to various herbal products, and unknown toxicity, undoubtedl... | yes |
22,791,700 | Are aGT gene polymorphisms ( M235T , T174M ) associated with coronary heart disease in a Chinese population? | {
"contexts": [
"The angiotensinogen (AGT) gene has been shown to be involved in the development of coronary heart disease (CHD). However, the results have been inconsistent. In this study, the authors performed a meta-analysis to clarify the associations between AGT polymorphisms and CHD risk among the Chinese p... | The meta-analyses indicated the significant associations of two AGT polymorphisms (M235T, T174M) with CHD risk in the Chinese population. | yes |
22,777,616 | Does myosin light chain kinase inhibitor inhibit dextran sulfate sodium-induced colitis in mice? | {
"contexts": [
"Myosin light chain kinase (MLCK) plays a central role in the mechanisms of barrier dysfunction, and intestinal epithelial MLCK protein expression is upregulated in active ulcerative colitis (UC). ML-7, a MLCK inhibitor, has been used in many MLCK studies. However, the effect of ML-7 has never bee... | ML-7 has a significant anti-colitis effect in colitis mice. It is mainly associated with the inhibition of the epithelial MLCK protein expression, resulting in ameliorated intestinal mucosal permeability. | yes |
22,788,896 | Is a sutureless aortic stent-graft based on a nitinol scaffold bonded to a compliant nanocomposite polymer durable for 10 years in a simulated in vitro model? | {
"contexts": [
"To physiologically test the durability of a sutureless aortic stent-graft based on nitinol bonded to polyhedral oligomeric silsesquioxane (POSS) and poly(carbonate-urea) urethane (PCU) for 10 years according to Food and Drug Administration guidelines.",
"Aortic stent-grafts (n = 4) were teste... | Simulated physiological in vivo hydrodynamic loading has no significant degradative effect on an innovative sutureless stent-graft made from POSS-PCU nanocomposite polymer. Sutureless technology incorporating nitinol stents proved to be robust, with no separation over an accelerated 10-year cycle, which may allow devel... | yes |
22,767,418 | Does anterior impingement test for labral lesions have high positive predictive value? | {
"contexts": [
"The anterior impingement test is intended to detect anterosuperior acetabular labral lesions. In patients treated for labral lesions its sensitivity is reportedly 95% to 100%, and in a small group of patients undergoing periacetabular osteotomy, its sensitivity was 59% and specificity 100%. Howev... | Although the sensitivity of the anterior impingement test did not reach a sufficient level for detecting anterosuperior labral lesions, we believe the high positive predictive value makes the test useful. | yes |
22,801,018 | Is fungicidal activity of lysozyme inhibited in vitro by commercial sinus irrigation solutions? | {
"contexts": [
"Lysozyme is an innate immune peptide with bactericidal and fungicidal activity (FA). Despite increased expression of lysozyme protein in chronic rhinosinusitis (CRS) sinus mucosa, CRS patients experience repeated bacterial and/or fungal infections. Commercial sinus irrigation solutions are often... | The in vitro FA of lysozyme is dependent on the ionic strength of the solution. The use of sinus irrigation solutions should be further evaluated with regard to maintaining functional activity of cationic antimicrobial peptides involved in sinonasal innate immunity. | yes |
22,798,268 | Are rheumatoid arthritis-associated polymorphisms at 6q23 associated with radiological damage in autoantibody-positive RA? | {
"contexts": [
"Recent studies have identified 6q23 as an important susceptibility locus for rheumatoid arthritis (RA), with risk alleles at 3 single-nucleotide polymorphisms combining to give an effect size greater than that of these markers individually. We investigated whether these polymorphisms are also ass... | Established RA risk markers at 6q23 are associated also with radiographic severity in autoantibody-positive RA; as for susceptibility, the association for these markers in combination is stronger than that for markers alone. | yes |
22,796,582 | Does the chemokine decoy receptor D6 prevent excessive inflammation and adverse ventricular remodeling after myocardial infarction? | {
"contexts": [
"Leukocyte infiltration in ischemic areas is a hallmark of myocardial infarction, and overwhelming infiltration of innate immune cells has been shown to promote adverse remodeling and cardiac rupture. Recruitment of inflammatory cells in the ischemic heart depends highly on the family of CC-chemok... | We show for the first time that the chemokine decoy receptor D6 limits CC-chemokine-dependent pathogenic inflammation and is required for adequate cardiac remodeling after myocardial infarction. | yes |
22,802,684 | Do self-assembling peptide-based nanoparticles enhance anticancer effect of ellipticine in vitro and in vivo? | {
"contexts": [
"Applications of the anticancer agent, ellipticine, have been limited by its hydrophobicity and toxicity. An efficient delivery system is required to exploit the enormous potential of this compound. Recently, EAK16-II, an ionic-complementary, self-assembling peptide, has been found to stabilize el... | The anticancer activity observed in this study coupled with minimal side effects encourages further development of peptide-mediated delivery of anticancer drugs, ellipticine in the present case, for clinical application. | yes |
22,775,211 | Does δ-Opioid receptor agonist SNC80 induce central antinociception mediated by Ca2+ -activated Cl- channels? | {
"contexts": [
"The aim of this study was to determine whether Ca(2+)-activated Cl(-) channels (CaCCs) are involved in central antinociception induced by the activation of µ-, δ- and κ-opioid receptors.",
"The nociceptive threshold for thermal stimulation was measured using the tail-flick test in Swiss mice.... | These data provide evidence for the involvement of CaCCs in δ-opioid receptor-induced central antinociception resulting from receptor activation by the agonist SNC80. CaCC activation does not appear to be involved when µ- and κ-opioid receptors are activated. | yes |
22,776,416 | Does cocultivation of phytopathogenic Fusarium and Alternaria strains affect fungal growth and mycotoxin production? | {
"contexts": [
"A laboratory study was conducted to evaluate the influence of cocultivation of toxigenic Fusarium (F.) and Alternaria (A.) fungi with respect to growth and mycotoxin production.",
"Fusarium culmorum Fc13, Fusarium graminearum Fg23 and two Alternaria tenuissima isolates (At18 and At220) were s... | The interfungal competitive effects aid the understanding of the processes of competition of both fungi in natural environments and the involvement of mycotoxins as antifungal factors. | yes |
22,799,288 | Does pristimerin inhibit breast cancer cell migration by up- regulating regulator of G protein signaling 4 expression? | {
"contexts": [
"Pristimerin isolated from Celastrus and Maytenus spp can inhibit proteasome activity. However, whether pristimerin can modulate cancer metastasis is unknown.",
"The impacts of pristimerin on the purified and intracellular chymotrypsin proteasomal activity, the levels of regulator of G protein... | Pristmerin inhibits proteasomal activity and increases the levels of RGS4, inhibiting the migration and invasion of breast cancer cells. | yes |
22,782,238 | Are multi-stemmed trees of Nothofagus pumilio second-growth forest in Patagonia formed by highly related individuals? | {
"contexts": [
"Multi-stemmed trees (tree clusters) in Nothofagus pumilio, a dominant tree species in Patagonia, are very uncommon and are restricted to the edge of second-growth forests following human-provoked fires. No vegetative reproduction has been reported so far. The genetic structure of multi-stemmed tr... | Tree clusters that are merged at the edge of the second-growth forest of N. pumilio are composed of stems of the same genotype and of other genotypes that are highly related (but not always). It is suggested that this peculiar genetic structure results from a combination of several causes, including selection for mergi... | yes |
22,770,698 | Does iron deficiency anemia in infancy exert long-term effects on the tibialis anterior motor activity during sleep in childhood? | {
"contexts": [
"To explore the eventual connection between iron deficiency anemia (IDA) in infancy and altered leg movements during sleep in a 10-year follow-up study in children who did or did not have IDA in infancy.",
"Polysomnographic studies were performed in 32 10-year-old children (13 females and 19 m... | The association between IDA in infancy, despite iron therapy, and PLMS in childhood could lead to new research in this area. Indeed, transient infantile IDA, a common nutritional problem among human infants, may turn out to be important for understanding the mechanisms of PLMS or restless legs syndrome, which are commo... | yes |
22,800,570 | Do human Vdelta1 gamma-delta T cells exert potent specific cytotoxicity against primary multiple myeloma cells? | {
"contexts": [
"Human gamma-delta (γδ) T cells are potent effector lymphocytes of innate immunity involved in anti-tumor immune surveillance. However, the Vδ1 γδ T-cell subset targeting multiple myeloma (MM) has not previously been investigated.",
"Vδ1 T cells were purified from peripheral blood mononuclear ... | We have shown for the first time that Vδ1 T cells are highly myeloma-reactive and have therefore established Vδ1 γδ T cells as a potential candidate for a novel tumor immunotherapy. | yes |
22,802,014 | Do neighbourhood satisfaction and happiness but not urbanization level affect self-rated health in adolescents? | {
"contexts": [
"It is hypothesized that neighbourhood satisfaction and subjective happiness are associated with self-rated health or mediate the effect from urbanization levels among youth.",
"Taiwan Youth Project was a cross-sectional study in two cities, Taipei and Yilan, Taiwan including 5,586 students. I... | Future public health intervention should attend to neighbourhood satisfaction and happiness for youth. | yes |
22,802,010 | Is ultrasonography a potent tool for the prediction of progressive joint destruction during clinical remission of rheumatoid arthritis? | {
"contexts": [
"Although \"clinical remission\" has been a realistic goal of treatment in rheumatoid arthritis (RA), there is evidence that subclinical synovitis is associated with ongoing structural damage even after clinical remission is achieved. In the study reported here, we assessed whether ultrasonography... | PD-US detects synovitis causing joint destruction even when the patient is in clinical remission. Thus, remission visible on US is essential to reach "true remission" of RA. | yes |
22,793,996 | Does bone marrow-derived fibroblast growth factor-2 induce glial cell proliferation in the regenerating peripheral nervous system? | {
"contexts": [
"Among the essential biological roles of bone marrow-derived cells, secretion of many soluble factors is included and these small molecules can act upon specific receptors present in many tissues including the nervous system. Some of the released molecules can induce proliferation of Schwann cells... | We conclude that FGF-2 secreted by BMMC strongly increases early glial proliferation, which can potentially improve PNS regeneration. | yes |
22,785,618 | Does inhibition of phosphodiesterase type 3 dilate the rat ductus arteriosus without inducing intimal thickening? | {
"contexts": [
" Prostaglandin E(1) (PGE(1)), via cAMP, dilates the ductus arteriosus (DA). For patients with DA-dependent congenital heart disease (CHD), PGE(1) is the sole DA dilator that is used until surgery, but PGE(1) has a short duration of action, and frequently induces apnea. Most importantly, PGE(1) in... | Because PDE3 inhibitors induced longer-lasting vasodilation without causing apnea or HA-mediated IT, they may be good alternatives to PGE(1) for patients with DA-dependent CHD. | yes |
22,797,797 | Is ischemia and reperfusion liver injury reduced in the absence of Toll-like receptor 4? | {
"contexts": [
"Toll-like receptor 4 (TLR4) is expressed on hepatic non-parenchymal cells and hepatocytes. Hepatic signaling through TLR4 is critical in the pathogenesis of ischemia reperfusion injury (IRI) and leads to the release of cytokines. The role of bone marrow-derived TLR4 in the early reperfusion stage... | Both TLR4 bone marrow-derived and non-bone marrow-derived cells are necessary in the initial process of hepatic injury. Activating TLR4-dependent signaling is required for IRI. The absence of the TLR4 gene plays a pivotal role in reducing hepatic IR injury. | yes |
22,796,314 | Is axon reflex-related hyperemia induced by short local heating reproducible? | {
"contexts": [
"The axon reflex (AR) flare is induced by antidromic activation of afferent C-fibers during nociceptive stimulation. This response has been suggested to be modulated by sympathetic activity and basal level of nitric oxide. In previously used protocols of local thermal hyperemia (LTH), AR flare has... | Single-point LDF is a reproducible technique of assessing AR flare on volar surface of the forearm when the heating period is reduced to 5 min and the recording sites are fixed. Using this new protocol, short-heating LTH has a potential to be used to evaluate the effects of acute physical or chemical interventions betw... | yes |
22,768,756 | Is [ Indian Hedgehog signaling involved in the stretch induced proliferation of osteoblast ]? | {
"contexts": [
"To observe the role of the Hedgehog (Hh) genes in the proliferation of osteoblasts upon mechanical tensile strains.",
"Primary osteoblasts harvested from newborn rat calvarial bone were subjected to 3% and 6% elongation of tensile stretches using Flexcell 4000 strain unit. The cultures were a... | The induced proliferation of osteoblasts by mechanical stretched is mediated at least in part by Indian Hedgehog (Ihh) signaling. | yes |
22,798,565 | Does rheumatoid factor determine structural progression of rheumatoid arthritis dependent and independent of disease activity? | {
"contexts": [
"Rheumatoid factor (RF) is prototypic for rheumatoid arthritis (RA) and serves diagnostic and prognostic purposes. RF is associated with joint destruction, but the role of disease activity as a potential mediator of these effects has not been clearly elucidated yet.",
"To investigate if higher... | The data reveal that damage progression in seropositive RA patients is related to higher levels of disease activity and to independent effects of RF, particularly on bone damage. This calls for consideration of RF status irrespective of disease activity. | yes |
22,800,400 | Is suppression of the basophil response to allergen during treatment with omalizumab dependent on 2 competing factors? | {
"contexts": [
"A recent study of subjects with peanut allergy treated with omalizumab generated some results that were concordant with a study of subjects with cat allergy treated with omalizumab. However, there were differences that provided additional insight into the nature of the cellular responses in aller... | The basophil response during treatment with omalizumab is a consequence of 2 competing factors: suppression of allergen-specific IgE on the cell surface versus increased intrinsic sensitivity to IgE-mediated stimulation. In subjects with peanut allergy, the basophil response appears to mitigate against the ability of o... | yes |
22,802,308 | Is suppression of plasma estrogen levels by letrozole and anastrozole related to body mass index in patients with breast cancer? | {
"contexts": [
"To investigate whether suppression of plasma estradiol and estrone sulfate levels by the aromatase inhibitors (AIs) anastrozole and letrozole is related to body mass index (BMI) in postmenopausal women with early estrogen receptor (ER) -positive breast cancer. Recent studies have reported that th... | The suppressed levels of plasma estradiol and estrone sulfate in postmenopausal women with early ER-positive breast cancer treated with the AIs anastrozole and letrozole are related to BMI. | yes |
22,771,778 | Is heart rate time irreversibility impaired in adolescent major depression? | {
"contexts": [
"We aimed to study heart rate time irreversibility--a nonlinear qualitative characteristics of heart rate variability indicating complexity of cardiac autonomic control at rest and in response to physiological stress (orthostasis) in never-treated major depressive disorder (MDD) adolescent female ... | This study revealed the impaired heart rate asymmetry pattern indicating an altered complexity of cardiac autonomic regulation in adolescent female patients suffering from MDD. | yes |
22,771,777 | Do mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture? | {
"contexts": [
"Mesenchymal stem cells (MSCs) are promising candidates for osteoarthritis (OA) therapies, although their mechanism of action remains unclear. MSCs have recently been discovered to secrete anti-inflammatory cytokines and growth factors. We studied the paracrine effects of MSCs on OA cartilage and ... | In an inflammatory environment, MSCs secrete factors which cause multiple anti-inflammatory effects and influence matrix turnover in synovium and cartilage explants. Thereby, the presented data encourage further study of MSCs as a treatment for joint diseases. | yes |
22,770,822 | Does endothelin-1 stimulate human trophoblast cell migration through Cdc42 activation? | {
"contexts": [
"This study investigated the role and mechanism of Cdc42 in Endothelin-1 (ET-1)-induced trophoblast cell migration.",
"We examined ET-1-mediated stimulation of trophoblast migration with HTR-8/SVneo cells. Cdc42 activation was measured after ET-1 treatment of HTR-8/SVneo cells. To determine th... | ET-1 stimulates EVT migration through Cdc42 activation. | yes |
22,785,109 | Is transforming growth factor β-induced peritoneal fibrosis mouse strain dependent? | {
"contexts": [
"Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis. The etiology is unclear, but genetic predisposition may be a contributing factor. We used adenovirus-mediated gene transfer of transforming growth factor (TGF) β1 to the peritoneum in four gene... | There were significant differences in mouse strain susceptibility to peritoneal fibrosis, suggesting that genetic factors may play a role in the development of peritoneal fibrosis and possibly EPS. As early TGFβ1 signaling mechanisms appear to be intact, we hypothesize that fibrosis resistance in the SJL/J mice lies fu... | yes |
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