pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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|---|---|---|---|---|
7,874,898 | Is gastric emptying in critically ill patients accelerated by adding cisapride to a standard enteral feeding protocol : results of a prospective , randomized , controlled trial? | {
"contexts": [
"To investigate the effect of cisapride, a relatively new prokinetic agent, on gastric emptying in critically ill patients.",
"Prospective, randomized, controlled study.",
"Adult medical/surgical intensive care unit in a university hospital.",
"Twenty-one consecutively enrolled patient... | The data indicate that gastric emptying in critically ill, sedated, and mechanically ventilated patients can be significantly improved by adding cisapride to a routine enteral feeding protocol. | yes |
7,880,512 | Does subarachnoid bupivacaine blockade decrease midazolam and thiopental hypnotic requirements? | {
"contexts": [
"To test the hypothesis that subarachnoid bupivacaine blockade decreases hypnotic requirements for thiopental sodium and midazolam.",
"Randomized, double-blind, placebo-controlled study.",
"Teaching hospital.",
"53 nonpremedicated ASA physical status I and II adult male patients schedu... | Subarachoid bupivacaine blockade decreases hypnotic requirements for both thiopental and midazolam. The results suggest that the reduction in hypnotic requirements is due to the decrease in afferent input induced by spinal anesthesia. | yes |
7,860,912 | Does continuous positive airway pressure increase heart rate variability in congestive heart failure? | {
"contexts": [
"Our objective was to determine whether continuous positive airway pressure augments the low heart rate variability of congestive heart failure, a marker of poor prognosis.",
"Nasal continuous positive airway pressure improves ventricular function in selected patients with heart failure.",
... | Short-term application of nasal continuous positive airway pressure increases heart rate variability and time and frequency domain indexes of parasympathetic activity without influencing cardiac sympathetic activity. This increase may occur reflexively, through stimulation of pulmonary mechanoreceptor afferents. | yes |
7,880,511 | Does midazolam antagonize fentanyl-mediated analgesia in surgical patients? | {
"contexts": [
"To determine whether midazolam possesses a clinically significant antianalgesic action in surgical patients.",
"Randomized, controlled study.",
"Inpatient anesthesia at a university department of neurosurgery.",
"2 groups of 10 patients each who were scheduled for supratentorial brain... | Under these clinical conditions, the administration of midazolam, when compared with droperidol, was not associated with signs of any antagonistic or antianalgesic action toward fentanyl-mediated analgesia. | no |
7,867,167 | Is nitric oxide responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo? | {
"contexts": [
"Experimental evidence suggests that flow-dependent dilatation of conduit arteries is mediated by nitric oxide (NO) and/or prostacyclin. The present study was designed to assess whether NO or prostacyclin also contributes to flow-dependent dilatation of conduit arteries in humans.",
"Radial ar... | The present investigation demonstrates that NO, but not prostacyclin, is essential for flow-mediated dilatation of large human arteries. Hence, this response can be used as a test for the L-arginine/NO pathway in clinical studies. | yes |
7,867,168 | Is late lumen loss after coronary angioplasty associated with the activation status of circulating phagocytes before treatment? | {
"contexts": [
"The purpose of this pilot study was to identify biological risk factors for restenosis after percutaneous transluminal coronary angioplasty (PTCA) to predict the long-term outcome of PTCA before treatment.",
"To investigate whether blood granulocytes and monocytes could determine luminal rena... | The results of the present study indicate that activated blood granulocytes prevent luminal renarrowing after PTCA, while activated blood monocytes promote late lumen loss. To validate this new finding, further study in an independent patient group is required. | yes |
7,874,927 | Is methacholine responsiveness associated with O3-induced decreases in FEV1? | {
"contexts": [
"Controlled human exposure studies have suggested that the National Ambient Air Quality Standard for ozone (O3) may not provide a margin of safety to protect the most susceptible members of the population from adverse health effects. Although the subgroups of the population that are most susceptib... | Although we were unable to find support for our hypothesis, we found, somewhat surprisingly, that respiratory symptoms were weakly associated or unassociated with FEV1 responses after O3 exposure. This finding implies that individuals may experience adverse effects, ie, respiratory symptoms, without large declines in l... | no |
7,882,484 | Does dehydroepiandrosterone sulfate predict cardiovascular death in postmenopausal women . The Rancho Bernardo Study? | {
"contexts": [
"High levels of dehydroepiandrosterone sulfate (DHEAS) appear to be associated with a reduced risk of fatal cardiovascular disease (CVD) in men. We examined the association between baseline DHEAS levels and the 19-year CVD and ischemic heart disease (IHD) mortality rates in 942 postmenopausal wome... | Although higher DHEAS levels were associated with several major CVD risk factors, they were unrelated to the risk of fatal CVD in women. | no |
7,868,101 | Does clinical and treatment correlate of access to Section 8 certificates for homeless mentally ill persons? | {
"contexts": [
"The study assessed how clients' housing preference and other variables were related to the acquisition of Section 8 certificates, facilitating independent living, for homeless persons with severe mental illness who were being served by an experimental assertive community treatment team.",
"Fo... | The study suggests that it is possible to honor the housing preferences of the majority of homeless persons with severe mental illness if adequate resources are provided. However, staff may view persons who have schizophrenia and more symptoms as needing more supervision than those clients prefer. Homeless mentally ill... | yes |
7,889,086 | Is microscopic salpingitis an etiologic factor of tubal pregnancy with intrauterine devices? | {
"contexts": [
"This prospective study was undertaken to test the hypothesis that microscopic chronic salpingitis is an etiologic factor in ectopic (tubal) pregnancy with an intrauterine device (IUD).",
"Fifty consecutive patients at a university hospital operated for tubal pregnancy fulfilled strict histolo... | The use of an IUD does not appear to cause tubal pregnancy by the mechanism of tubal inflammation or presence of salpingitis isthmica nodosa. Therefore, other mechanisms by which an IUD might cause ectopic pregnancy should be considered. | no |
7,867,360 | Does pentoxifylline prevent a decrease in arterial oxygen tension in oleic acid-induced lung injury? | {
"contexts": [
"a) To determine whether pentoxifylline has a preventive effect on the decrease in PaO2 that is caused by oleic acid, and whether pentoxifylline facilitates normalization of PaO2 from the decreased state. b) To examine whether pentoxifylline can attenuate an increase in pulmonary vascular permeabi... | Pentoxifylline is a noteworthy drug that could be a candidate as a therapy to help prevent hypoxemia in lung injuries that share a common mechanism with oleic acid-induced lung injury. | yes |
7,884,578 | Does tCV 116 prevent progressive renal injury in rats with extensive renal mass ablation? | {
"contexts": [
"The objective of this study was to determine the renal protective effects of TCV 116, a novel, non-competitive, angiotensin II type 1 (AT1) receptor antagonist, in rats with 5/6 renal mass ablation.",
"Adult male Wistar rats were subjected to 5/6 nephrectomy and treated continuously with eith... | These data show that TCV 116 prevents the development of systemic hypertension, glomerular capillary hypertension, proteinuria and glomerulosclerosis in rats with reduced renal mass. We therefore conclude that the renal protection associated with angiotensin I converting enzyme inhibitors and other pharmacologic blocke... | yes |
7,878,533 | Does platelet attachment stimulate endothelial cell regeneration after arterial injury? | {
"contexts": [
"Arterial injury is associated with endothelial disruption and attachment of platelets to an exposed subintimal layer. A variety of factors released by platelets may affect the ability of endothelial cells bordering an injury to regenerate. In this study an organ culture model of arterial injury w... | Platelets stimulate endothelial regeneration at a rate equal to that observed with the potent endothelial mitogen basic fibroblast growth factor. Because this effect was not demonstrated with the supernatant of aggregated platelets, endothelial regeneration may be dependent on attachment of the platelets to the area of... | yes |
22,791,949 | Does knockdown of liver-intestine cadherin decrease BGC823 cell invasiveness and metastasis in vivo? | {
"contexts": [
"To assess BGC823 gastric cancer (GC) cell metastasis after knockdown of liver-intestine cadherin (CDH17) and the therapeutic value of CDH17-RNAi-lentivirus in vivo.",
"We evaluated primary tumor growth and assessed local infiltration and systemic tumor dissemination using an orthotopic implan... | Our data establish a foundation for future studies of the comprehensive protein expression patterns and effects of CDH17 in GC. | yes |
22,791,947 | Are decreased blood riboflavin levels correlated with defective expression of RFT2 gene in gastric cancer? | {
"contexts": [
"To investigate the relationship between blood riboflavin levels and riboflavin transporter 2 (RFT2) gene expression in gastric carcinoma (GC) development.",
"High-performance liquid chromatography was used to detect blood riboflavin levels in patients with GC. Real-time fluorogenic quantitati... | Defective expression of RFT2 is associated with the development of GC and this may represent a mechanism underlying the decreased plasma riboflavin levels in GC. | yes |
22,782,643 | Does costs explained by function rather than diagnosis -- result from the SNAC Nordanstig elderly cohort in Sweden? | {
"contexts": [
"Because the prevalence of many brain disorders rises with age, and brain disorders are costly, the economic burden of brain disorders will increase markedly during the next decades.",
"The purpose of this study is to analyze how the costs to society vary with different levels of functioning a... | It is the level of functioning, rather than the presence of a brain disorder diagnosis, which predicts costs. ADLs are better explanatory variables of costs than Mini mental state examination. Most people in a population-based cohort are zero users of care. | yes |
22,772,712 | Does overexpression of miR-92a correlate with tumor metastasis and poor prognosis in patients with colorectal cancer? | {
"contexts": [
"MicroRNAs regulate gene expression at the post-transcriptional level and play important roles in cancer development, progression, and metastasis. The aim of this study was to investigate the expression of miR-92a in colorectal cancer and the normal adjacent mucosa and its potential relevance to c... | This study revealed that miR-92a overexpression was correlated with specific colorectal cancer biopathologic features, such as TNM stage, lymph node and distant metastases, and poor survival of the patients, indicating that miR-92a may serve as a molecular prognostic marker for colorectal cancer and disease progression... | yes |
22,798,197 | Does ezetimibe inhibit lymphatic transport of esterified cholesterol but not free cholesterol in thoracic lymph duct-cannulated rats? | {
"contexts": [
"Ezetimibe has been shown to inhibit dietary cholesterol absorption in animal models and humans, but studies on lymphatic lipid transport have not yet been performed. Rats subjected to permanent lymph duct cannulation were used to investigate the effects of ezetimibe on lipid transport.",
"Rat... | This is the first direct evidence that ezetimibe inhibits esterified but not free cholesterol lymphatic transport in thoracic duct-cannulated rats. The results also indicate that ezetimibe is not involved in the lymphatic transport of triacylglycerols, phospholipids, or α-tocopherol. | yes |
22,771,144 | Do prevalence of mood and substance use disorders among patients seeking primary care office-based buprenorphine/naloxone treatment? | {
"contexts": [
"Psychiatric comorbidity can adversely affect opioid dependence treatment outcomes. While the prevalence of psychiatric comorbidity among patients seeking methadone maintenance treatment has been documented, the extent to which these findings extend to patients seeking primary care office-based bu... | Mood and substance use comorbidity is prevalent among patients seeking primary care office-based buprenorphine/naloxone treatment. The findings support the need for clinicians to assess and address these conditions. | yes |
22,786,447 | Does thyroid function influence serum apolipoprotein B-48 levels in patients with thyroid disease? | {
"contexts": [
"Apolipoprotein B-48 (apoB-48) is a major apolipoprotein of intestine-derived chylomicrons (CM) and CM remnants (CMR). Clinically overt hypothyroidism (OH) has been associated with premature and accelerated coronary atherosclerosis. To clarify the clinical significance of apoB-48 measurement in pa... | Increased serum apoB-48 concentrations and CMR may contribute to the increased risk of atherosclerosis and premature coronary artery disease in the hypothyroid state. | yes |
22,786,446 | Does apolipoprotein A-I inhibit CD40 proinflammatory signaling via ATP-binding cassette transporter A1-mediated modulation of lipid raft in macrophages? | {
"contexts": [
"Apolipoprotein A-I (apoA-I), the major component of high-density lipoprotein (HDL), has been recently found to suppress inflammation. This study was to investigate the effects and potential mechanisms of apoA-I on the CD40/CD40 ligand (CD40L) proinflammatory signaling pathway.",
"Human THP-1 ... | ApoA-I suppresses CD40 proinflammatory signaling in macrophages by preventing TRAF-6 translocation to lipid rafts through ABCA1-dependent regulation of free cholesterol (FC) efflux, which may present a novel mechanism of apoA-I-mediated inflammation inhibition in macrophages. | yes |
22,786,445 | Is optic nerve head circulation determined by pulse wave analysis significantly correlated with cardio ankle vascular index , left ventricular diastolic function , and age? | {
"contexts": [
"To determine whether there is a significant correlation between optic nerve head circulation determined by pulse wave analysis of laser speckle flowgraphy (LSFG), and the cardio-ankle vascular index (CAVI), left ventricular (LV) function, and age.",
"Forty-nine men who visited the Vascular Fu... | The BOT of the optic nerve head circulation determined by LSFG was significantly correlated with age but was independent of cardiac diastolic function and arterial stiffness. This suggests that the damage to different organs increases with age. Our results confirmed that BOT can be helpful in evaluating physiological a... | yes |
22,786,444 | Is small low-density lipoprotein cholesterol concentration a determinant of endothelial dysfunction by peripheral artery tonometry in men? | {
"contexts": [
"Endothelial dysfunction is an initial step in the progression of atherosclerosis. Precise measurements of lipoprotein subclass distribution by high-performance liquid chromatography (HPLC) have been established. Here, we investigated the potential associations between lipoprotein subclass cholest... | Small LDL cholesterol concentration was an important, independent determinant of endothelial dysfunction in men. | yes |
22,770,562 | Is angiopoietin-2 a potential mediator of endothelial barrier dysfunction following cardiopulmonary bypass? | {
"contexts": [
"Endothelial activation leading to vascular barrier dysfunction and organ failure is a well-recognized complication of cardiovascular surgery with cardiopulmonary bypass (CPB). The endothelial-specific angiopoietin-Tie2 ligand-receptor system has been identified as a non-redundant regulator of end... | Collectively, our results suggest that Ang-2 is a putative mediator of endothelial barrier dysfunction after CPB. These findings suggest that targeting the Ang/Tie2 pathway may mitigate organ dysfunction and improve outcome in patients undergoing CPB. | yes |
22,768,331 | Is vitamin D a major determinant of bone mineral density at school age? | {
"contexts": [
"Vitamin D insufficiency in children may have long-term skeletal consequences as vitamin D affects calcium absorption, bone mineralization and bone mass attainment.",
"This school-based study investigated vitamin D status and its association with vitamin D intake and bone health in 195 Finnish... | Vitamin D insufficiency was common even when vitamin D intake exceeded the recommended daily intake. Vitamin D status was a key determinant of BMD. The findings suggest urgent need to increase vitamin D intake to optimize bone health in children. | yes |
22,768,332 | Do multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds? | {
"contexts": [
"Nesprins (Nuclear envelope spectrin-repeat proteins) are a novel family of giant spectrin-repeat containing proteins. The nesprin-1 and nesprin-2 genes consist of 146 and 116 exons which encode proteins of ∼1mDa and ∼800 kDa is size respectively when all the exons are utilised in translation. How... | These studies suggest nesprins act as highly versatile tissue specific intracellular protein scaffolds and identify potential novel functions for nesprins beyond cytoplasmic-nuclear coupling. These alternate functions may also account for the diverse range of disease phenotypes observed when these genes are mutated. | yes |
22,770,603 | Is elevated homocysteine associated with poorer self-perceived physical health in older men : the Health in Men Study? | {
"contexts": [
"To determine the relationship between high total homocysteine (tHcy) and self-perceived physical health, by investigating the associations between tHcy, the methylenetetrahydrofolate reductase (MTHFR) 677T polymorphism and physical health-related quality of life (HRQOL).",
"We conducted a cro... | Elevated tHcy is associated with poorer self-perceived physical health in community-dwelling older men. The results of this study support further longitudinal investigations to assess this relationship prospectively. | yes |
22,773,554 | Does brain-derived neurotrophic factor Val66Met polymorphism predict worse functional outcome after surgery in patients with unruptured brain arteriovenous malformation? | {
"contexts": [
"The Val66Met polymorphism of brain-derived neurotrophic factor is associated with decreased brain-derived neurotrophic factor secretion and poor outcome after acute neurological injury. We hypothesized that the Met allele is associated with worsening of functional outcome after brain arteriovenou... | The Val66Met polymorphism is associated with worsened surgical outcome in patients with unruptured brain arteriovenous malformation, a group that currently has no good risk predictors. Further studies replicating these findings are needed. | yes |
22,802,725 | Does niche-associated activation of rac promote the asymmetric division of Drosophila female germline stem cells? | {
"contexts": [
"Drosophila female germline stem cells (GSCs) reside adjacent to a cellular niche that secretes Bone Morphogenetic Protein (BMP) ligands and anchors the GSCs through adherens junctions. The GSCs divide asymmetrically such that one daughter remains in the niche as a GSC, while the other is born awa... | Thus, the GSCs, an adult stem cell present in a cellular niche, have a niche-associated polarity that couples control of the division plane with increased response to an extracellular maintenance signal. Other processes work in parallel with the Rac-mediated polarity to ensure a robust pattern of asymmetric division. W... | yes |
22,776,010 | Does testosterone replacement therapy improve erythrocyte membrane lipid composition in hypogonadal men? | {
"contexts": [
"The aim of this study was to investigate the effects of testosterone replacement therapy (TRT) on erythrocyte membrane (EM) lipid composition and physico-chemical properties in hypogonadal men.",
"EM isolated from three patients before and after TRT with injectable testosterone undecanoate or... | The TRT induced increase of PE content and the reduction of saturation in the PC acyl chains induced alterations in the structure of EM could result in higher flexibility of the erythrocytes. The increase of the SM-metabolizing enzyme neutral sphingomyelinase, which regulates the content of ceramide in membranes has a ... | yes |
22,795,399 | Does hIV-1 gp120 induce autophagy in cardiomyocytes via the NMDA receptor? | {
"contexts": [
"HIV-1 envelope glycoprotein gp120 (gp120) is considered as one of the major virulent proteins responsible for the involvement of the cardiovascular system. Autophagy as a form of self maintenance plays important roles in cell survival and death. HIV-1 gp120 is reported to induce autophagy in a va... | In summary, our research demonstrated for the first time that HIV-1 gp120 could induce autophagy of cardiomyocytes and the NMDA receptor, JNK and class III PI3K were involved in this process. This observation provides a new insight into the mechanisms of in the cardiovascular involvement during HIV-1 infection. | yes |
22,798,065 | Is adipocyte-released insulin-like growth factor-1 regulated by glucose and fatty acids and controls breast cancer cell growth in vitro? | {
"contexts": [
"Type 2 diabetes and obesity are associated with increased risk of site-specific cancers. We have investigated whether metabolic alterations at the level of adipose-derived differentiating cells may affect specific phenotypes of breast cancer cells.",
"Growth profiles of breast cancer cell lin... | IGF-1 release by adipocytes is regulated by glucose and fatty acids and may contribute to the control of cancer cell growth in obese individuals. | yes |
22,774,846 | Do higher glycosylated hemoglobin levels increase the risk of overactive bladder syndrome in patients with type 2 diabetes mellitus? | {
"contexts": [
"To assess overactive bladder and its component symptoms among patients with type 2 diabetes mellitus and to explore whether higher glycosylated hemoglobin and other factors increase the risk of overactive bladder symptoms.",
"A total of 279 diabetes mellitus patients from our outpatient clini... | Patients with type 2 mellitus present more overactive bladder symptoms/urgency and nocturia than controls. Among diabetic patients, higher glycosylated hemoglobin level represents an independent predictor of overactive bladder /urgency, urge urinary incontinence and nocturia. | yes |
22,773,109 | Is modest increase in peak VO2 related to better clinical outcomes in chronic heart failure patients : results from heart failure and a controlled trial to investigate outcomes of exercise training? | {
"contexts": [
"The prognostic ability of a single measurement of peak oxygen uptake (VO(2)) is well established in patients with chronic heart failure. The relation between a change in peak VO(2) and clinical outcomes is not well defined.",
"This investigation determined whether an increase in peak VO(2) wa... | Among patients with chronic systolic heart failure, a modest increase in peak VO(2) over 3 months was associated with a more favorable outcome. Monitoring the change in peak VO(2) for such patients may have benefit in assessing prognosis. | yes |
22,771,190 | Is apolipoprotein E mimetic more effective than apolipoprotein A-I mimetic in reducing lesion formation in older female apo E null mice? | {
"contexts": [
"The apolipoprotein E mimetic peptide Ac-hE18A-NH(2), capable of reducing plasma cholesterol and possessing anti-inflammatory properties, was compared with the well-studied anti-atherogenic apoA-I mimetic peptide 4F for reducing lesion formation in female apoE null mice with already existing lesio... | Although both peptides had similar anti-inflammatory properties, Ac-hE18A-NH(2) was more effective in inhibiting lesions than 4F at the same dose, frequency, and route of administration, perhaps due to its cholesterol reducing properties. | yes |
22,796,578 | Does thrombomodulin protect endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling? | {
"contexts": [
"We have recently reported that recombinant human soluble thrombomodulin (rTM) counteracted capillary leakage associated with engraftment, as well as sinusoidal obstructive syndrome after hematopoietic stem cell transplantation. These observations prompted us to explore whether rTM possessed cytop... | TM may be useful for prevention, as well as treatment of endothelial cell damage after hematopoietic stem cell transplantation. | yes |
22,784,362 | Is blood pressure response to exercise exaggerated in normotensive diabetic patients? | {
"contexts": [
"The aim of this study was to investigate the blood pressure (BP) response to exercise in normotensive patients with type II diabetes mellitus (DM).",
"A cross-sectional study was carried out on 75 normotensive subjects with type 2 DM (group 1), and 70 age-gender matched normotensive healthy v... | SBP response to exercise is exaggerated in normotensive diabetic patients compared with non-diabetic subjects. DM, office SBP and male gender are independent predictors of peak SBP. DM, office SBP and age are independent predictors of HRE. | yes |
22,772,045 | Does tGFβ inhibition during expansion phase increase the chondrogenic re-differentiation capacity of human articular chondrocytes? | {
"contexts": [
"Autologous chondrocyte implantation is a cell-based treatment to repair articular cartilage defects, relying on the availability of expanded (de-differentiated) chondrocytes. Unfortunately, the expansion process causes several phenotypical changes, requiring re-establishment of the native chondro... | TGFβ-depletion during expansion improves the re-differentiation capacity of chondrocytes and inhibits hypertrophy. These results indicate the importance of the expansion medium composition to improve chondrogenic re-differentiation and to inhibit hypertrophy. | yes |
22,768,894 | Is in type 2 diabetes patients , insulin glargine associated with lower postprandial release of intact proinsulin compared with sulfonylurea treatment? | {
"contexts": [
"Our objective was to investigate how postprandial processing of intact proinsulin is influenced by different pharmacological strategies in type 2 diabetes mellitus (T2DM).",
"This exploratory, nonrandomized, cross-sectional study recruited T2DM patients and healthy subjects. Upon recruitment,... | Treatment of T2DM with GLA plus MET or DPP-4-I plus MET was associated with a more physiological postprandial secretion pattern of the β cell compared with those treated with SU plus MET. | yes |
22,789,940 | Is ischemia change in stable coronary artery disease an independent predictor of death and myocardial infarction? | {
"contexts": [
"The aim of this study was to evaluate the independent prognostic significance of ischemia change in stable coronary artery disease (CAD).",
"Recent randomized trials in stable CAD have suggested that revascularization does not improve outcomes compared with optimal medical therapy (MT). In co... | In stable CAD, ischemia worsening is an independent predictor of death or MI, resulting in significantly improved risk reclassification when added to previously known predictors. | yes |
22,791,277 | Are b-type natriuretic peptide levels correlated with birth-weight discordance in monochorionic-diamniotic twins without twin-twin transfusion syndrome? | {
"contexts": [
"To determine whether B-type natriuretic peptide (BNP) levels in umbilical cord blood (UCB) and amniotic fluid (AF) are correlated with birth-weight discordances in monochorionic-diamniotic twins.",
"The UCB-BNP and AF-BNP levels were determined at birth in 36 twin-pairs without twin-twin tran... | Cardiac dysfunction occurs in both larger and smaller co-twins with increasing birth-weight discordances, even in the absence of TTTS. | yes |
22,775,199 | Does insulin at normal physiological levels prolong QT ( c ) interval in thorough QT studies performed in healthy volunteers? | {
"contexts": [
"Food is known to shorten the QT(c) (QT(c)I and QT(c)F) interval and has been proposed as a non-pharmacological method of confirming assay sensitivity in thorough QT (TQT) studies and early phase studies in medicines research. Intake of food leads to a rise in insulin levels together with the rele... | The findings of this study demonstrate that there was no change in QT(c) during the euglycaemic clamp. Given that insulin was raised to physiological concentrations comparable with those seen after a meal, whilst the release of C-peptide was suppressed, insulin appears to have no effect on the QT(c) interval in either ... | no |
22,766,991 | Is lINE-1 hypomethylation in noncancerous esophageal mucosae associated with smoking history? | {
"contexts": [
"Cancer cells exhibit two types of DNA methylation alterations: global DNA hypomethylation and site-specific CpG island promoter hypermethylation. Selected gene promoter hypermethylation in normal esophageal mucosae has attracted attention as a surrogate marker for the epigenetic field defect indu... | A history of tobacco use was significantly associated with LINE-1 hypomethylation in noncancerous esophageal mucosae of ESCC patients. These results support the potential of LINE-1 methylation level as an indicator of epigenetic field for ESCC cancerization, particularly when caused by tobacco smoking. | yes |
22,783,816 | Is non-dipping pattern in untreated hypertensive patients related to increased pulse wave velocity independent of raised nocturnal blood pressure? | {
"contexts": [
"Non-dipper pattern, characterized by diminished nocturnal decline in blood pressure (BP), is associated with an increase in cardiovascular events. Carotid-femoral pulse wave velocity (CF-PWV) has been accepted as the gold standard measurement of arterial stiffness. CF-PWV is a well-recognized pre... | Our results suggest that diminished nocturnal decline in BP is independently associated with PWV and nocturnal BP rather than daytime BP. Non-dipper pattern, mainly related to increased PWV and impaired modulation of vascular smooth muscle tone during the night, may justify an increased cardiovascular risk in these pat... | yes |
22,770,785 | Do evaluation of arterial waveform derived variables for an assessment of volume resuscitation in mechanically ventilated burn patients? | {
"contexts": [
"The purpose of this study was to assess the usefulness of stroke volume variations to monitor the early fluid resuscitation in mechanically ventilated burn ICU patients.",
"Data of 29 burn patients (APACHE II - 9.8±3.6, SAPS II - 29±5, TBSA - 39.5±14) were prospectively included in this obser... | Our results suggest that measurement of stroke volume variations by arterial pulse contour analysis is valuable in monitoring volume administration and in predicting volume responsiveness during the early postburn period. | yes |
22,770,636 | Is p50 sensory gating a trait marker of the bipolar spectrum? | {
"contexts": [
"Sensory gating deficit, assessed by a paired auditory stimulus paradigm (P50), has been reported as a stable marker of schizophrenia. The aim of this study was to explore if this neurophysiological disturbance also fulfilled stability criteria in the bipolar disorder (BD) spectrum bipolar, as sta... | The findings suggest that this inhibitory deficit can be considered characteristic of the illness and that the intensity of the gating abnormality varies according to the severity of BD. | yes |
22,800,450 | Does [ Mid-long term follow-up result in correction of extreme myopia by posterior chamber phakic intraocular lens ]? | {
"contexts": [
"To evaluate the mid-long term stability and safety of posterior chamber phakic intraocular lens (ICL) implantation for the correction of extreme myopia.",
"This retrospective study included 993 eyes of 498 patients received ICL implantation from June 1996 to December 2008. Multivariate analys... | Correction of high myopia by ICL implantation is a safe procedure and the results are stable. | yes |
22,796,753 | Do amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy? | {
"contexts": [
"We aimed to investigate the influence of oligomeric forms of β-amyloid (Aβ) and the influence of the duration of exposure on the development of tau phosphorylation.",
"Aβ oligomers were injected intracranially either acutely into 5-month-old rTg4510 mice and tissue was collected 3 days later,... | Soluble Aβ(1-42) oligomers have long-lasting effects on tau phosphorylation in the rTg4510 model, possibly due to elevations in GSK3. These data suggest that even brief elevations in Aβ production, may have enduring impact on the risk for tauopathy. | yes |
22,800,828 | Is gain of human telomerase RNA gene associated with progression of cervical intraepithelial neoplasia grade I or II? | {
"contexts": [
"The 3q26 chromosome region, where the human telomerase RNA gene (hTERC) is located, is a biomarker for cervical cancer and precancerous lesions. The aim of this study was to confirm the value of measuring hTERC gene gain in predicting the progression of cervical intraepithelial neoplasia grade I ... | In conclusion, measurement of hTERC gene gain in CIN-I or CIN-II patients using liquid-based cytological samples could be a useful biomarker to predict the progression of such cervical lesions. In addition, a 4:4 or N:≥5 signal ratio pattern may indicate the unlikeness of spontaneous regression of CIN-I or CIN-II lesio... | yes |
22,800,829 | Is overexpression of interleukin-l7 in tumor-associated macrophages correlated with the differentiation and angiogenesis of laryngeal squamous cell carcinoma? | {
"contexts": [
"Interleukin-l7 (IL-17), which exerts strong pro-inflammatory effects, has emerged as an important mediator in inflammation-associated cancer. The aim of this study was to clarify the relationship between IL-17 and tumor associated macrophages (TAMs), and the correlation of the microvessel density... | IL-17 was expressed by TAMs, and IL-17 may significantly correlate to the differentiation and angiogenesis in the development of LSCC. | yes |
22,789,310 | Do influence of post-warm-up recovery time on swim performance in international swimmers? | {
"contexts": [
"Swimmers must enter a marshalling call-room 20min prior to racing, which results in some swimmers completing their warm-up 45min pre-race. Since a recovery period longer than 15-20min may prove problematic, this study examined 200m freestyle performance after a 20 and 45min post-warm-up recovery ... | 200m freestyle performance is faster 20min post-warm-up when compared to 45min probably due to better T(core) maintenance. This has implications for swim race preparation as warm-up procedures should be completed close to entering the pre-race call room, in order to maintain elevated core temperature. | yes |
22,800,987 | Does the vitamin D receptor activator paricalcitol prevent fibrosis and diastolic dysfunction in a murine model of pressure overload? | {
"contexts": [
"Activation of the vitamin D-vitamin D receptor (VDR) axis has been shown to reduce blood pressure and left ventricular (LV) hypertrophy. Besides cardiac hypertrophy, cardiac fibrosis is a key element of adverse cardiac remodeling. We hypothesized that activation of the VDR by paricalcitol would p... | Treatment with the selective VDR activator paricalcitol reduces myocardial fibrosis and preserves diastolic LV function due to pressure overload in a mouse model. This is associated with a reduced percentage of fibrosis and a decreased expression of ANP and several other tissue markers. | yes |
22,773,978 | Do transforming growth factor-β neutralizing antibodies inhibit subretinal fibrosis in a mouse model? | {
"contexts": [
"To determine the involvement of the transforming growth factor (TGF)-β with the development of experimental subretinal fibrosis in a mouse model.",
"Subretinal fibrosis was induced by subretinal injection of macrophage-rich peritoneal exudate cells (PECs) and the local expression of TGF-β iso... | Our results indicate that TGF-β signaling may contribute to the pathogenesis of subretinal fibrogenesis and TGF-β inhibition may provide an effective, novel treatment of advanced and late-stage neovascular age-related macular degeneration. | yes |
22,768,143 | Does lobe-specific calcium binding in calmodulin regulate endothelial nitric oxide synthase activation? | {
"contexts": [
"Human endothelial nitric oxide synthase (eNOS) requires calcium-bound calmodulin (CaM) for electron transfer but the detailed mechanism remains unclear.",
"Using a series of CaM mutants with E to Q substitution at the four calcium-binding sites, we found that single mutation at any calcium-bi... | Our results clearly demonstrate that CaM controls eNOS electron transfer primarily through its lobe-specific calcium binding. | yes |
22,792,043 | Is sonographic gallbladder abnormality associated with intravenous immunoglobulin resistance in Kawasaki disease? | {
"contexts": [
"Kawasaki disease (KD) is an acute systematic vasculitis in children which causes coronary arterial lesions and hydrops of gallbladder. Our objective is to correlate the clinical significance and influence on disease outcome of patients with gallbladder abnormalities in Kawasaki dissease.",
"C... | Sonographic gallbladder abnormalities are associated with higher CRP, GPT, neutrophil and IVIG resistance in KD. It can be used as a predictor of IVIG resistance in patients with KD. | yes |
22,799,881 | Does ligand-free estrogen receptor activity complement IGF1R to induce the proliferation of the MCF-7 breast cancer cells? | {
"contexts": [
"Ligand-dependent activation of the estrogen receptor (ER) as well as of the insulin-like growth factor type 1 (IGF1R) induces the proliferation of luminal breast cancer cells. These two pathways cooperate and are interdependent. We addressed the question of the mechanisms of crosstalk between the... | The basal ER activity in the absence of ligand is sufficient to allow efficient mitogenic action of IGF1R agonists and needs to be blocked to prevent the cell cycle progression. | yes |
22,803,596 | Is haptoglobin present in albumin used as a replacement solution for plasma exchange? | {
"contexts": [
"Albumin is frequently used as replacement solution when performing plasma exchanges (PEs) and there are no previous data about the content of haptoglobin. The objective was to study the content of haptoglobin in albumin solution and the effect of PE on the removal of haptoglobin, a plasma protein... | Albumin solution used for PE contained haptoglobin and it explained in part the kinetics removal of plasma haptoglobin observed in the patients. | yes |
22,797,174 | Are iL-1β induction and IL-6 suppression associated with aggravated neuronal damage in a lipopolysaccharide-pretreated kainic acid-induced rat pup seizure model? | {
"contexts": [
"Reportedly, hippocampal neuronal degeneration by kainic acid (KA)-induced seizures in rats <14 days old was enhanced by lipopolysaccharide (LPS). This study was to test the hypothesis that cytokines such as interleukin (IL)-1β, IL-6 and tumor necrosis factor-α are associated with aggravated neuro... | Our results showed an increase in the proconvulsant cytokine IL-1β and a decrease in a potentially neuroprotective cytokine, IL-6, in rat pups treated with LPS + KA. These results warrant further investigation into the possible role of IL-1β induction and IL-6 suppression in LPS-promoted neuronal damage. | yes |
22,794,117 | Does eldecalcitol normalize bone turnover markers regardless of their pre-treatment levels? | {
"contexts": [
"Three-year treatment with eldecalcitol has been shown to improve lumbar and total hip bone mineral density (BMD), decrease bone turnover markers, and lower the incidences of vertebral and wrist fractures in patients with osteoporosis more than with treatment with alfacalcidol under vitamin D repl... | Eldecalcitol normalizes, but does not overly suppress, bone turnover regardless of baseline levels of bone turnover markers. Thus, it is unlikely that eldecalcitol treatment will increase the risk of severely suppressed bone turnover and therefore deterioration of bone quality, at least for a treatment duration of 3 ye... | yes |
22,771,041 | Does phosphatidylinositol-3-phosphate clearance play a key role in autophagosome completion? | {
"contexts": [
"The biogenesis of autophagosomes, the hallmark of autophagy, depends on the function of the autophagy-related (Atg) proteins and the generation of phosphatidylinositol-3-phosphate (PtdIns3P) at the phagophore assembly site (PAS), the location where autophagosomes arise. The current model is that ... | Our data thus reveal a key role for PtdIns3P turnover in the regulation of the late steps of autophagosome biogenesis and indicate that the disassembly of the Atg machinery from the surface of autophagosomes is a requisite for their fusion with the vacuole. | yes |
22,771,042 | Is sUMOylation of the α-kleisin subunit of cohesin required for DNA damage-induced cohesion? | {
"contexts": [
"Cohesion between sister chromatids is fundamental to ensure faithful chromosome segregation during mitosis and accurate repair of DNA damage postreplication. At the molecular level, cohesion establishment involves two defined events, a chromatin binding step and a chromatid entrapment event drive... | These findings demonstrate that SUMOylation of Mcd1 is a novel prerequisite for the establishment of DNA damage-induced cohesion at DSB-proximal regions and cohesion-associating regions (CARs) genome-wide. | yes |
22,768,159 | Does intrathecal injection of spironolactone attenuate radicular pain by inhibition of spinal microglia activation in a rat model? | {
"contexts": [
"Microglia might play an important role in nociceptive processing and hyperalgesia by neuroinflammatory process. Mineralocorticoid receptor (MR) expressed on microglia might play a central role in the modulation of microglia activity. However the roles of microglia and MR in radicular pain were no... | These results suggest that intrathecal delivery spironolactone has therapeutic effects on radicular pain in rats. Decreasing the activation of glial cells, the production of proinflammatory cytokines and down-regulating the expression and phosphorylation of NMDA receptors in the spinal dorsal horn and dorsal root gangl... | yes |
22,768,155 | Is resistance to first-line anti-TB drugs associated with reduced nitric oxide susceptibility in Mycobacterium tuberculosis? | {
"contexts": [
"The relative contribution of nitric oxide (NO) to the killing of Mycobacterium tuberculosis in human tuberculosis (TB) is controversial, although this has been firmly established in rodents. Studies have demonstrated that clinical strains of M. tuberculosis differ in susceptibility to NO, but how... | There is a correlation between resistance to first-line anti-TB drugs and reduced NO susceptibility in clinical strains of M. tuberculosis. Further studies including the mechanisms of reduced NO susceptibility are warranted and could identify targets for new therapeutic interventions. | yes |
22,770,375 | Does intracultural variation of knowledge about wild plant used in the Biosphere Reserve Grosses Walsertal ( Austria )? | {
"contexts": [
"Leading scholars in ethnobiology and ethnomedicine continuously stress the need for moving beyond the bare description of local knowledge and to additionally analyse and theorise about the characteristics and dynamics of human interactions with plants and related local knowledge. Analyses of the ... | A majority of respondents is familiar with wild plant uses, however to varying degrees. Knowledge variations depend on the socio-demographic and geographic background of the informants as well as on the domains of knowledge under investigation: women, older informants and homegardeners report more human medicinal appli... | yes |
22,776,386 | Does travel-related change of residence lead to a transitory stress reaction in humans? | {
"contexts": [
"It is well known that animals show a stress response when confronted with a novel environment. The aim of the this study was to investigate whether humans show a similar response by studying the reaction to a travel-related transitory change of residence.",
"Forty-eight individuals (32 women,... | The results indicate that not only the change of residence but also its anticipation affects individuals in a transient way. The findings are relevant not only for the basic understanding of the reaction to novel environments but also to travel, tourism as well as rehabilitation, and spa-research. | yes |
22,801,439 | Does slug regulate Cyclin D1 expression by ubiquitin-proteasome pathway in prostate cancer cells? | {
"contexts": [
"Cyclin D1 is an important cell cycle regulatory proteins, which is a functional target of Slug in the regulation of cell growth of prostate cancer cells. But the pathway of these two factors interacting with each other is unclear.",
"The infectde PCa Cells were treated with proteasome inhibit... | We found that forced expression of Slug inhibited proliferation of prostate cancer cells through downregulation of cyclin D1 expression. And Slug regulates cyclin D1 expression by ubiquitin-proteasome pathway in PCa cells. | yes |
22,773,699 | Does antenatal diagnosis of fetal genotype determine if maternal hyperglycemia due to a glucokinase mutation requires treatment? | {
"contexts": [
"In women with hyperglycemia due to heterozygous glucokinase (GCK) mutations, the fetal genotype determines its growth. If the fetus inherits the mutation, birth weight is normal when maternal hyperglycemia is not treated, whereas intensive treatment may adversely reduce fetal growth. However, fet... | In pregnancies where the mother has hyperglycemia due to a GCK mutation, knowing the fetal GCK genotype guides the management of maternal hyperglycemia. Fetal genotyping should be performed when fetal DNA is available from invasive prenatal diagnostic testing. | yes |
22,795,338 | Is hyperinsulinemia and insulin resistance associated with low T₃/T₄ ratio in pre diabetic euthyroid Pakistani subjects? | {
"contexts": [
"To investigate the relationship of thyroid hormones in glucose homeostasis in impaired glucose-tolerant subjects with normal thyroid functions.",
"Cross-sectional analysis was carried out in (n=260) impaired glucose-tolerant (IGT) and normal glucose-tolerant (NGT) subjects. Thyrotropin (TSH),... | Hyperinsulinemia and insulin resistance are associated with low T₃/T₄ ratio in pre-diabetic euthyroid Pakistani subjects. | yes |
22,792,520 | Is preoperative plasma fibrinogen level a useful predictor of adjacent organ involvement in patients with advanced gastric cancer? | {
"contexts": [
"The aim of the present study was to assess the association between the pre-operative plasma fibrinogen level and the adjacent organ involvement in advanced gastric cancer.",
"A total of 923 pre-operative plasma samples were obtained from 923 patients diagnosed clinically as having advanced ga... | Plasma fibrinogen was found to be a clinically useful marker of adjacent organ involvement and overall survival. When a high fibrinogen level is encountered, preoperatively, adjacent organ involvement should be suspected in clinically advanced gastric cancer. | yes |
22,799,548 | Is participation in the child and adult care food program associated with more nutritious foods and beverages in child care? | {
"contexts": [
"Nearly two million California children regularly spend time in child care. Surprisingly little is known about the nutrition environments of these settings. The aim of this study was to compare foods and beverages served to 2- to 5-year-olds by type of child care and participation in the federally... | CACFP participation may be one means by which reimbursement for food can be increased and food offerings improved. Further research should investigate whether promoting CACFP participation can be used to provide healthier nutrition environments in child care and prevent obesity in young children. | yes |
22,798,635 | Is dying a transition? | {
"contexts": [
"End-of-life care is designed as response to patients' verbally communicated needs. The concept of dying as a process would allow us to improve care. This concept may combine the needs of the dying, their outburst of emotions, gradual maturation, family processes, acute problems such as decreasing... | Understanding dying as transition may induce a radical reinterpretation of what patients need. | yes |
22,781,305 | Are regulatory T cells the most important determinant factor of hepatitis B infection prognosis : a systematic review and meta-analysis? | {
"contexts": [
"Association of increased levels of CD4(+)CD25(+) regulatory T cells (Tregs) with impaired immune response and hepatitis B infection progression has been proposed. For determination of Tregs various effects among hepatitis B infected patients we performed a meta-analysis of the available literatur... | Tregs influence HBV infected patients in various states. Tregs determine the disease prognosis by leading to infection progression and impairing immune response. So, Tregs are therapeutic target for immunotherapy of HBV infection. | yes |
22,771,446 | Do vascular endothelial growth factor polymorphisms increase the risk of developing Graves ' disease? | {
"contexts": [
"Graves' disease (GD) is a consequence of genetic and environmental factors. Vascular endothelial growth factor (VEGF) is a strong angiogenic and mitogenic factor, which plays a key role in lymphocyte infiltration, and hypervascularization in the thyroid gland of patients with GD.",
"The aim o... | VEGF +405 polymorphism may be a risk factor for GD, while the -2578 SNP is related with increased autoantibody production. | yes |
22,769,054 | Is plasmacytoid dendritic cell interferon-α production to R-848 stimulation decreased in male infants? | {
"contexts": [
"Sex differences in response to microbial infections, especially viral ones, may be associated with Toll-like receptor (TLR)-mediated responses by plasmacytoid dendritic cells (pDCs).",
"In this study, we identified sex differences in human infant pDC interferon-α production following challeng... | Androgen-mediated regulation of pDC TLR7-driven innate immune responses may contribute to the observed sex differences in response to infections during early infancy. | yes |
22,792,318 | Do pancreatic cancer cells enhance the ability of collagen internalization during epithelial-mesenchymal transition? | {
"contexts": [
"Extracellular matrix (ECM) remodeling is predominantly mediated by fibroblasts using intracellular and extracellular pathways. Although it is well known that extracellular degradation of the ECM by proteases derived from cancer cells facilitates cellular invasion, the intracellular degradation of... | Pancreatic cancer cells are capable of collagen internalization, which is enhanced by EMT. This ECM clearance system may be a novel mechanism for cellular invasion and a potential therapeutic target in pancreatic cancer. | yes |
22,778,024 | Does rab11 regulate planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis? | {
"contexts": [
"Xenopus embryonic skin is composed of the superficial layer with defined apicobasal polarity and the inner layer lacking the apical domain. Multiciliated cells (MCCs) originate in the inner layer of the epidermal ectoderm and subsequently migrate to the surface. How MCCs acquire the apicobasal po... | These results establish a requirement for Rab11 in MCC development and support a two-step model, in which the initial polarization of MCC precursors is critical for their integration into the superficial cell layer. | yes |
22,773,566 | Does selenite enhance and prolongs the efficacy of cisplatin treatment of human ovarian tumor xenografts? | {
"contexts": [
"Our earlier studies on ovarian tumor xenografts provide evidence that co-treatment with selenite prevents the development of resistance to single-treatment using the drug cisplatin. However, these studies did not reflect the repetitive schedule of clinical chemotherapy. We hypothesized that selen... | The ability of selenite to prolong the effectiveness of repetitive cisplatin treatment, most likely by preventing the development of resistance, makes it a strong candidate for inclusion in clinical trials. | yes |
22,773,567 | Do expanded effector memory T-lymphocytes in DBA/2 mice inhibit the growth of SL2 tumours? | {
"contexts": [
"The aim of this study was to analyse changes in levels of memory T-lymphocytes during growth of SL2 tumours in DBA/2 mice and to evaluate whether these lymphocytes may have an inhibitory effect on tumour growth.",
"Percentages of naïve (CD8+CD44lowCD62L+), central memory (CD8+CD44high CD62L+)... | SL2 tumours induce expansion of effector memory lymphocytes in DBA/2 mice. However, expanded effector memory lymphocytes do not inhibit the growth of tumours. | no |
22,803,838 | Is rET/PTC rearrangement prevalent in follicular Hürthle cell carcinomas? | {
"contexts": [
"The molecular alterations underlying follicular Hürthle cell carcinomas (FHCCs) are largely unknown. In an attempt to clarify this issue, we analysed a series of Hürthle cell tumours for the presence of RET/PTC and PAX8/PPARG rearrangements and BRAF, HRAS and NRAS mutations.",
"We investigate... | Our study has shown a significant association between RET/PTC rearrangements and FHCCs with a solid growth pattern, thus raising the possibility of using tyrosine kinase inhibitors for the treatment of patients with FHCCs, which are often refractory to radioiodine treatment. | yes |
22,771,185 | Do fermentable fibers affect satiety or food intake by women who do not practice restrained eating? | {
"contexts": [
"Fiber is thought to enhance satiety, although not all fibers are equally effective. Colonic fermentation may influence satiety and food intake.",
"To test the satiating properties of four isolated fibers added to chocolate crisp bars.",
"Within-subject preload design with repeated measure... | Functional fibers incorporated into chocolate bars at high fiber doses produce greater gastrointestinal symptoms than control, but do not alter satiety, hunger, or food intake compared with control in the short term. | no |
22,791,118 | Does mometasone furoate nasal spray relieve the ocular symptoms of seasonal allergic rhinoconjunctivitis? | {
"contexts": [
"Recent studies have examined the effects of intranasal corticosteroids (INSs) in relieving the ocular symptoms of seasonal allergic rhinoconjunctivitis (SAR) and perennial allergic rhinitis. However, because most of these studies were based on subjective assessments by patients, the associated fa... | In patients with SAR, INSs tend to decrease the substance P concentration in tears, which is correlated with the severity of ocular and nasal symptoms. | yes |
22,777,681 | Does angiopoietin-2 inhibition using siRNA or the peptide antagonist L1-10 result in antitumor activity in human neuroblastoma? | {
"contexts": [
"The angiopoietin/Tie-2 system has been identified as a key role player in tumor angiogenesis. We investigated whether angiopoietin-2 could be a promising target in human neuroblastoma.",
"Angiopoietin-2 down-regulation by siRNA or shRNA was evaluated in vitro in Kelly cells. Angiopoietin-2 sh... | This first demonstration of beneficial angiopoietin-2 inhibition in neuroblastoma offers an additional approach for future therapy strategies, especially by using L1-10 in the setting of minimal residual disease. | yes |
22,796,541 | Do tertiary centres have improved survival compared to other hospitals in the Copenhagen area after out-of-hospital cardiac arrest? | {
"contexts": [
"Out-of-hospital cardiac arrest (OHCA) has been reported to carry very varying morbidity and mortality. However, it remains unclear whether this is caused by intrinsic factors of the OHCA or due to the level of in-hospital care. The aim of this study is to compare 30-day and long-term mortality af... | Admission to tertiary centres is associated with lower mortality rates after OHCA compared with non-tertiary hospitals. | yes |
22,795,519 | Is the Modification of Diet in Renal Disease 4-calculated glomerular filtration rate a better prognostic factor of cardiovascular events than classical cardiovascular risk factors in patients with peripheral arterial disease? | {
"contexts": [
"Risk prediction is important in medical management, especially to optimize patient management before surgical intervention. No quantitative risk scores or predictors are available for patients with peripheral arterial disease (PAD). Surgical risk and prognosis are usually based on anesthetic scor... | The MDRD-4 GFR was a better predictor of risk of death or infarction than classical cardiovascular risk factors in patients with PAD. This suggests that its routine use in the initial evaluation in patients with PAD is beneficial. | yes |
22,782,273 | Is tracheostomy tube change before day 7 associated with earlier use of speaking valve and earlier oral intake? | {
"contexts": [
"Presence of a tracheostomy tube often decreases the patient's ability to communicate and to tolerate oral intake. The initial tracheostomy tube change is often recommended between day 7 and 14 post insertion. Local guidelines permit tracheostomy tube change 5 days after insertion.",
"We hypot... | Tracheostomy tube change before day 7 is associated with earlier ability to tolerate speaking valve and oral intake. In this series, early tracheostomy tube change was not associated with an increased rate of complications. | yes |
22,802,934 | Does modulation of Lactobacillus plantarum gastrointestinal robustness by fermentation conditions enable identification of bacterial robustness markers? | {
"contexts": [
"Lactic acid bacteria (LAB) are applied worldwide in the production of a variety of fermented food products. Additionally, specific Lactobacillus species are nowadays recognized for their health-promoting effects on the consumer. To optimally exert such beneficial effects, it is considered of grea... | Transcriptome trait matching enabled the identification of biomarkers for bacterial (gut-)robustness, which is important for our molecular understanding of GI-tract survival and could facilitate the design of culture conditions aimed to enhance probiotic culture robustness. | yes |
22,802,935 | Does anti-obesity sodium tungstate treatment trigger axonal and glial plasticity in hypothalamic feeding centers? | {
"contexts": [
"This study aims at exploring the effects of sodium tungstate treatment on hypothalamic plasticity, which is known to have an important role in the control of energy metabolism.",
"Adult lean and high-fat diet-induced obese mice were orally treated with sodium tungstate. Arcuate and paraventri... | Altogether, these results suggest that sodium tungstate regulates proteins involved in axonal and glial plasticity. The fact that sodium tungstate could modulate hypothalamic plasticity and networks in adulthood makes it a possible and interesting therapeutic strategy not only for obesity management, but also for other... | yes |
22,787,469 | Does magnetic bionanoparticle enhance homing of endothelial progenitor cells in mouse hindlimb ischemia? | {
"contexts": [
"Poor homing efficiency is one of the major limitations of current stem cell therapy. Magnetic bionanoparticles (MPs) obtained from Magnetospirillum sp. AMB-1 have a lipid bilayer membrane and ferromagnetic properties. We evaluated a novel priming strategy using MPs to enhance the homing of transp... | MP transfer with magnet application can be a promising novel strategy to enhance homing efficacy and outcomes of current stem cell therapy. | yes |
22,767,966 | Is youth screen-time behaviour associated with cardiovascular risk in young adulthood : the European Youth Heart Study? | {
"contexts": [
"We prospectively examined the association of TV viewing, computer use, and total screen time in adolescence, and change in these behaviours, with cardiovascular disease (CVD) risk factors in young adulthood.",
"This was a prospective cohort study among Danish men and women (n = 435) followed ... | Prolonged TV viewing and total screen time during leisure time in adolescence, and increases in these behaviours, are associated with unfavourable levels of several cardiovascular risk factors in young adulthood. | yes |
22,774,612 | Does [ Radioiodine-131 therapy improve sex hormones and sexual function in male patients with Graves ' disease ]? | {
"contexts": [
"To observe the changes of sex hormones and sexual function in male patients with Graves' disease (GD) after Radioiodine-131 (I-131) therapy.",
"Thirty-four male GD patients, aged 21 -40 (32.3 +/- 6.7) years, were treated with I-131 at the dose of 111 - 407 (237.8 +/- 51.8) MBq. The levels of ... | The E2, T and LH levels are increased while the IIEF-5 score decreased markedly in male GD patients. Six-month treatment with I-131 can not only restore the E2, T and LH levels to normal but also significantly improve the patient's sexual function. | yes |
22,799,322 | Does smad4 expression in hepatocellular carcinoma differ by hepatitis status? | {
"contexts": [
"Primary hepatocellular carcinoma (HCC) is a common malignancy often related to hepatitis viral infection. Smad4 is known to mediate the TGF-β pathway to suppress tumorigenesis. However, the function of Smad4 in HCC is still controversial. In this study we compared levels of Smad4 in HCC tissues w... | Patients with hepatitis viral infection, at higher risk for HCC, exhibited increased Smad4 protein expression suggesting hepatitis virus may modulate Smad4 expression, which is functionally distinct from its putative role as a TSG. Smad4 expression may thus be an applicable marker for diagnosis and/or a target to devel... | yes |
22,800,678 | Do a clinical `` near miss '' highlights risk management issues surrounding ultrasound-guided and wire-localised breast resections? | {
"contexts": [
"The introduction of the National Health Service (NHS) Breast Screening Programme has led to a considerable increase in the detection of impalpable breast cancer. Patients with impalpable breast cancer typically undergo oncological resection facilitated either by the insertion of guide wires place... | It is evident that breast cancer patients undergoing image-guided resection are exposed to an additional layer of clinical risks. These risks are not offset by the World Health Organisation surgical safety checklist in its present guise. Here, we review a number of simple and inexpensive changes to the system that may ... | yes |
22,766,986 | Is sentinel node biopsy indicated for thin melanomas ≥0.76 mm? | {
"contexts": [
"A consensus for which patients with thin melanomas (≤1 mm) should undergo sentinel lymph node biopsy (SLNB) is not established. We describe a large single institution experience with SLNB for thin melanomas to determine factors predictive of nodal metastases.",
"Retrospective review from 2005... | SLN metastases were seen in 8.4% of thin melanomas ≥0.76 mm, including 5% of T1a melanomas ≥0.76 mm. We believe these rates are sufficient to justify consideration of SLNB in these patients, while the indications for SLNB in melanomas <0.76 mm remain to be defined. | yes |
22,767,636 | Does serum sclerostin increase in healthy adult men during bed rest? | {
"contexts": [
"Animal models and human studies suggest that osteocytes regulate the skeleton's response to mechanical unloading in part by an increase in sclerostin. However, few studies have reported changes in serum sclerostin in humans exposed to reduced mechanical loading.",
"We determined changes in se... | In healthy men subjected to controlled bed rest for 90 d, serum sclerostin increased, with a peak at 60, whereas serum PTH declined, and urinary calcium and bone resorption markers increased. | yes |
22,778,713 | Does topical application of Sadat-Habdan mesenchymal stimulating peptide ( SHMSP ) accelerate wound healing in diabetic rabbits? | {
"contexts": [
"Diminished wound healing is a common problem in diabetic patients due to diminished angiogenesis. SHMSP was found to promote angiogenesis. The present study was carried out to examine the effect of this peptide in healing of wounds in diabetic rabbits.",
"Twenty male New Zealand rabbits were ... | Topical application of SHMSP improves wound healing in diabetic rabbits. | yes |
22,781,319 | Do [ Analysis of resistance phenotype and homology of Klebsiella pneumoniae in burn patients ]? | {
"contexts": [
"To study the resistance phenotype and homology of Klebsiella pneumoniae (KPN) in burn patients with infection.",
"Fifty-four strains of KPN were isolated from wound excretion, blood, sputum, venous catheter, feces, and oral cavity of patients hospitalized in Institute of Burn Research of Sout... | KPN in burn patients with infection in our institute are highly resistant to commonly used antibiotics in clinic, but carbapenems antibiotics can be used for the treatment. Most of the ESBL-producing KPN strains carry two or three drug-resistant genes, and the main gene type of them is type A. | yes |
22,796,080 | Do deficits in visuospatial processing contribute to quantitative measures of freezing of gait in Parkinson 's disease? | {
"contexts": [
"The aim of this study was to investigate whether an objective measure of freezing of gait (FOG) using a validated alternating stepping in place (SIP) task, is related to executive and/or visuospatial cognitive impairment in Parkinson's disease (PD).",
"We studied prospectively 30 PD subjects ... | Deficits in visuospatial perception and reasoning not in executive function differentiated freezers from non-freezers. Deficits in visuospatial processing negatively correlated with all SIP freeze metrics, whereas deficits in executive function were only correlated with SIP arrhythmicity, the FOGq total and the duratio... | yes |
22,769,442 | Do tumor necrosis factor-α and Porphyromonas gingivalis lipopolysaccharides decrease periostin in human periodontal ligament fibroblasts? | {
"contexts": [
"Periostin is a matricellular protein essential for tissue integrity and maturation and is believed to have a key function as a modulator of periodontal ligament (PDL) homeostasis. The aim of this study is to evaluate whether periodontal disease-associated pathogen-related virulence factors (endot... | Inflammatory mediators (TNF-α) and bacterial virulence factors (P. gingivalis LPS) decrease periostin expression in human PDL fibroblasts. These results support a potential mechanism by which periostin alterations could act as a contributing factor during periodontal disease progression. | yes |
22,798,527 | Does orexin-A facilitate emergence from propofol anesthesia in the rat? | {
"contexts": [
"Hypothalamic orexinergic neurons play a critical role in the promotion and maintenance of wakefulness in mammals. Previous studies have demonstrated that activities of orexinergic neurons were inhibited by isoflurane and sevoflurane, and microinjection of orexin facilitated the emergence from vol... | Our findings indicate that activity of orexinergic neurons is inhibited by propofol anesthesia, and the orexin signals in basal forebrain are involved in anesthesia-arousal regulation from propofol anesthesia. | yes |
22,784,579 | Does novel Markov model of induced pluripotency predict gene expression changes in reprogramming? | {
"contexts": [
"Somatic cells can be reprogrammed to induced-pluripotent stem cells (iPSCs) by introducing few reprogramming factors, which challenges the long held view that cell differentiation is irreversible. However, the mechanism of induced pluripotency is still unknown.",
"Inspired by the phenomenolog... | This lands further support on our general rules of gene regulation network in iPSC reprogramming. This model may help uncover the basic mechanism of reprogramming and improve the efficiency of converting somatic cells to iPSCs. | yes |
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