diff --git "a/data/ge_llm/ge_l3_dataset.jsonl" "b/data/ge_llm/ge_l3_dataset.jsonl"
new file mode 100644--- /dev/null
+++ "b/data/ge_llm/ge_l3_dataset.jsonl"
@@ -0,0 +1,200 @@
+{"question_id": "GEL3-0000", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OPALIN\nCell line: DMS53_LUNG\nLineage: Lung\nDisease: Lung Neuroendocrine Tumor\nCRISPR gene effect (Chronos): 0.024\nDependency probability: 0.010\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OPALIN", "model_id": "ACH-000698", "lineage": "Lung", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1258}}
+{"question_id": "GEL3-0001", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: RTP2\nCell line: NCIH322_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): -0.014\nDependency probability: 0.016\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "RTP2", "model_id": "ACH-000837", "lineage": "Lung", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1341}}
+{"question_id": "GEL3-0002", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: GRM4\nCell line: KS1_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): 0.165\nDependency probability: 0.011\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1337 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "GRM4", "model_id": "ACH-000631", "lineage": "CNS/Brain", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1337}}
+{"question_id": "GEL3-0003", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: KRTAP19-3\nCell line: LN443_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): -0.255\nDependency probability: 0.253\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1131 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "KRTAP19-3", "model_id": "ACH-000673", "lineage": "CNS/Brain", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1131}}
+{"question_id": "GEL3-0004", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR6S1\nCell line: SKMEL5_SKIN\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): 0.189\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1261 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR6S1", "model_id": "ACH-000730", "lineage": "Skin", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1261}}
+{"question_id": "GEL3-0005", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TSSK2\nCell line: HCC461_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): -0.347\nDependency probability: 0.354\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "TSSK2", "model_id": "ACH-000339", "lineage": "Lung", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1340}}
+{"question_id": "GEL3-0006", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR51T1\nCell line: HEYA8_OVARY\nLineage: Ovary/Fallopian Tube\nDisease: Ovarian Epithelial Tumor\nCRISPR gene effect (Chronos): -0.063\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1259 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR51T1", "model_id": "ACH-000542", "lineage": "Ovary/Fallopian Tube", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1259}}
+{"question_id": "GEL3-0007", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SDR9C7\nCell line: HCC1500_BREAST\nLineage: Breast\nDisease: Breast Ductal Carcinoma In Situ\nCRISPR gene effect (Chronos): -0.019\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "SDR9C7", "model_id": "ACH-000349", "lineage": "Breast", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1341}}
+{"question_id": "GEL3-0008", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TRPM1\nCell line: A375_SKIN\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): -0.110\nDependency probability: 0.047\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "TRPM1", "model_id": "ACH-000219", "lineage": "Skin", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1340}}
+{"question_id": "GEL3-0009", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: CDCP2\nCell line: NCCOS1X2C1_BONE\nLineage: Bone\nDisease: Osteosarcoma\nCRISPR gene effect (Chronos): 0.072\nDependency probability: 0.017\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "CDCP2", "model_id": "ACH-002778", "lineage": "Bone", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1297}}
+{"question_id": "GEL3-0010", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: GLT6D1\nCell line: COV413A_OVARY\nLineage: Ovary/Fallopian Tube\nDisease: Ovarian Epithelial Tumor\nCRISPR gene effect (Chronos): -0.027\nDependency probability: 0.036\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "GLT6D1", "model_id": "ACH-001340", "lineage": "Ovary/Fallopian Tube", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1297}}
+{"question_id": "GEL3-0011", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: KLK9\nCell line: SJSA1_BONE\nLineage: Bone\nDisease: Osteosarcoma\nCRISPR gene effect (Chronos): -0.029\nDependency probability: 0.037\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "KLK9", "model_id": "ACH-000748", "lineage": "Bone", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1297}}
+{"question_id": "GEL3-0012", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: DDI1\nCell line: P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Myeloid\nDisease: Acute Myeloid Leukemia\nCRISPR gene effect (Chronos): 0.015\nDependency probability: 0.016\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "DDI1", "model_id": "ACH-000770", "lineage": "Myeloid", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1341}}
+{"question_id": "GEL3-0013", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: RBPJL\nCell line: CALU6_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): 0.000\nDependency probability: 0.039\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1339 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "RBPJL", "model_id": "ACH-000264", "lineage": "Lung", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1339}}
+{"question_id": "GEL3-0014", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: S100A7A\nCell line: HCC3153_BREAST\nLineage: Breast\nDisease: Invasive Breast Carcinoma\nCRISPR gene effect (Chronos): 0.105\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 568 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "S100A7A", "model_id": "ACH-002324", "lineage": "Breast", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 568}}
+{"question_id": "GEL3-0015", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: ZSWIM2\nCell line: SNU685_ENDOMETRIUM\nLineage: Uterus\nDisease: Endometrial Carcinoma\nCRISPR gene effect (Chronos): 0.034\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "ZSWIM2", "model_id": "ACH-000407", "lineage": "Uterus", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1297}, "gold_reasoning": "ZSWIM2 is described as: zinc finger SWIM-type containing 2. In SNU685_ENDOMETRIUM (Uterus), CRISPR knockout of ZSWIM2 shows no significant effect on cell viability. ZSWIM2 is part of the reference non-essential gene set, indicating it is dispensable for cell survival across multiple cell types and screening contexts. ZSWIM2 is non-essential in 1297 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (0.034) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0016", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: GHSR\nCell line: HMC18_BREAST\nLineage: Breast\nDisease: Invasive Breast Carcinoma\nCRISPR gene effect (Chronos): 0.111\nDependency probability: 0.007\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "GHSR", "model_id": "ACH-000721", "lineage": "Breast", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1341}}
+{"question_id": "GEL3-0017", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TSSK1B\nCell line: SUM185PE_BREAST\nLineage: Breast\nDisease: Invasive Breast Carcinoma\nCRISPR gene effect (Chronos): -0.060\nDependency probability: 0.027\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "TSSK1B", "model_id": "ACH-001392", "lineage": "Breast", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1341}}
+{"question_id": "GEL3-0018", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: CDCP2\nCell line: MFM223_BREAST\nLineage: Breast\nDisease: Invasive Breast Carcinoma\nCRISPR gene effect (Chronos): -0.113\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "CDCP2", "model_id": "ACH-001819", "lineage": "Breast", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1297}}
+{"question_id": "GEL3-0019", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SLC6A7\nCell line: WM88_SKIN\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): 0.142\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "SLC6A7", "model_id": "ACH-000899", "lineage": "Skin", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1297}}
+{"question_id": "GEL3-0020", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: NR2E1\nCell line: JHH1_LIVER\nLineage: Liver\nDisease: Hepatocellular Carcinoma\nCRISPR gene effect (Chronos): -0.117\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "NR2E1", "model_id": "ACH-000620", "lineage": "Liver", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1340}}
+{"question_id": "GEL3-0021", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR5W2\nCell line: JIMT1_BREAST\nLineage: Breast\nDisease: Invasive Breast Carcinoma\nCRISPR gene effect (Chronos): 0.012\nDependency probability: 0.018\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1260 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR5W2", "model_id": "ACH-000711", "lineage": "Breast", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1260}}
+{"question_id": "GEL3-0022", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SLC32A1\nCell line: MDAMB468_BREAST\nLineage: Breast\nDisease: Invasive Breast Carcinoma\nCRISPR gene effect (Chronos): -0.080\nDependency probability: 0.044\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "SLC32A1", "model_id": "ACH-000849", "lineage": "Breast", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1297}}
+{"question_id": "GEL3-0023", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: RXFP2\nCell line: PSS089_BONE\nLineage: Bone\nDisease: Osteosarcoma\nCRISPR gene effect (Chronos): -0.008\nDependency probability: 0.019\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "RXFP2", "model_id": "ACH-002470", "lineage": "Bone", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1341}}
+{"question_id": "GEL3-0024", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: NR2E1\nCell line: C2BBE1_LARGE_INTESTINE\nLineage: Bowel\nDisease: Colorectal Adenocarcinoma\nCRISPR gene effect (Chronos): 0.109\nDependency probability: 0.009\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "NR2E1", "model_id": "ACH-000009", "lineage": "Bowel", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1340}}
+{"question_id": "GEL3-0025", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: ALPI\nCell line: NB10_AUTONOMIC_GANGLIA\nLineage: Peripheral Nervous System\nDisease: Neuroblastoma\nCRISPR gene effect (Chronos): -0.080\nDependency probability: 0.066\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "ALPI", "model_id": "ACH-002278", "lineage": "Peripheral Nervous System", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1340}}
+{"question_id": "GEL3-0026", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: LRRC10\nCell line: MM473_SKIN\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): -0.025\nDependency probability: 0.021\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1317 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "LRRC10", "model_id": "ACH-001972", "lineage": "Skin", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1317}}
+{"question_id": "GEL3-0027", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: KCNA10\nCell line: PECAPJ34CLONEC12_UPPER_AERODIGESTIVE_TRACT\nLineage: Head and Neck\nDisease: Head and Neck Squamous Cell Carcinoma\nCRISPR gene effect (Chronos): -0.368\nDependency probability: 0.318\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1336 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "KCNA10", "model_id": "ACH-000606", "lineage": "Head and Neck", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1336}}
+{"question_id": "GEL3-0028", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR5V1\nCell line: GCT_SOFT_TISSUE\nLineage: Soft Tissue\nDisease: Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma/High-Grade Spindle Cell Sarcoma\nCRISPR gene effect (Chronos): 0.061\nDependency probability: 0.009\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR5V1", "model_id": "ACH-000835", "lineage": "Soft Tissue", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1208}}
+{"question_id": "GEL3-0029", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SCRT2\nCell line: SU8686_PANCREAS\nLineage: Pancreas\nDisease: Pancreatic Adenocarcinoma\nCRISPR gene effect (Chronos): 0.070\nDependency probability: 0.017\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "SCRT2", "model_id": "ACH-000114", "lineage": "Pancreas", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1297}}
+{"question_id": "GEL3-0030", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: CYP2C19\nCell line: DBTRG05MG_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): 0.379\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "CYP2C19", "model_id": "ACH-000863", "lineage": "CNS/Brain", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1341}, "gold_reasoning": "CYP2C19 is described as: cytochrome P450 family 2 subfamily C member 19. In DBTRG05MG_CENTRAL_NERVOUS_SYSTEM (CNS/Brain), CRISPR knockout of CYP2C19 shows no significant effect on cell viability. CYP2C19 is part of the reference non-essential gene set, indicating it is dispensable for cell survival across multiple cell types and screening contexts. CYP2C19 is non-essential in 1341 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (0.379) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0031", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: DCANP1\nCell line: MG63_BONE\nLineage: Bone\nDisease: Osteosarcoma\nCRISPR gene effect (Chronos): -0.169\nDependency probability: 0.092\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "DCANP1", "model_id": "ACH-000359", "lineage": "Bone", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1258}}
+{"question_id": "GEL3-0032", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: C1orf146\nCell line: PEO4_OVARY\nLineage: Ovary/Fallopian Tube\nDisease: Ovarian Epithelial Tumor\nCRISPR gene effect (Chronos): 0.090\nDependency probability: 0.024\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "C1orf146", "model_id": "ACH-001632", "lineage": "Ovary/Fallopian Tube", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1258}}
+{"question_id": "GEL3-0033", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: HTR6\nCell line: HT1080_SOFT_TISSUE\nLineage: Soft Tissue\nDisease: Fibrosarcoma\nCRISPR gene effect (Chronos): -0.018\nDependency probability: 0.027\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "HTR6", "model_id": "ACH-000054", "lineage": "Soft Tissue", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1341}}
+{"question_id": "GEL3-0034", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: KRTAP9-3\nCell line: MCAS_OVARY\nLineage: Ovary/Fallopian Tube\nDisease: Ovarian Epithelial Tumor\nCRISPR gene effect (Chronos): -0.208\nDependency probability: 0.188\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 566 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "KRTAP9-3", "model_id": "ACH-000796", "lineage": "Ovary/Fallopian Tube", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 566}}
+{"question_id": "GEL3-0035", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: MUC17\nCell line: OUMS23_LARGE_INTESTINE\nLineage: Bowel\nDisease: Colorectal Adenocarcinoma\nCRISPR gene effect (Chronos): -0.370\nDependency probability: 0.279\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "MUC17", "model_id": "ACH-000296", "lineage": "Bowel", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1258}}
+{"question_id": "GEL3-0036", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SAMD7\nCell line: NCIH28_PLEURA\nLineage: Pleura\nDisease: Pleural Mesothelioma\nCRISPR gene effect (Chronos): 0.227\nDependency probability: 0.003\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1315 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "SAMD7", "model_id": "ACH-000648", "lineage": "Pleura", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1315}}
+{"question_id": "GEL3-0037", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR52B6\nCell line: UACC812_BREAST\nLineage: Breast\nDisease: Invasive Breast Carcinoma\nCRISPR gene effect (Chronos): 0.103\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR52B6", "model_id": "ACH-000568", "lineage": "Breast", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1208}}
+{"question_id": "GEL3-0038", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: RAX2\nCell line: SCC4_UPPER_AERODIGESTIVE_TRACT\nLineage: Head and Neck\nDisease: Head and Neck Squamous Cell Carcinoma\nCRISPR gene effect (Chronos): 0.037\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1276 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "RAX2", "model_id": "ACH-000238", "lineage": "Head and Neck", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1276}}
+{"question_id": "GEL3-0039", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR1G1\nCell line: OUMS23_LARGE_INTESTINE\nLineage: Bowel\nDisease: Colorectal Adenocarcinoma\nCRISPR gene effect (Chronos): 0.035\nDependency probability: 0.017\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR1G1", "model_id": "ACH-000296", "lineage": "Bowel", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1208}}
+{"question_id": "GEL3-0040", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: ABCG8\nCell line: nan\nLineage: Soft Tissue\nDisease: Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma/High-Grade Spindle Cell Sarcoma\nCRISPR gene effect (Chronos): -0.006\nDependency probability: 0.027\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "ABCG8", "model_id": "ACH-002782", "lineage": "Soft Tissue", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1341}}
+{"question_id": "GEL3-0041", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: LHFPL5\nCell line: NCIH2452_PLEURA\nLineage: Pleura\nDisease: Pleural Mesothelioma\nCRISPR gene effect (Chronos): -0.033\nDependency probability: 0.039\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1186 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "LHFPL5", "model_id": "ACH-000092", "lineage": "Pleura", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1186}}
+{"question_id": "GEL3-0042", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: GLT6D1\nCell line: SNU1_STOMACH\nLineage: Esophagus/Stomach\nDisease: Esophagogastric Adenocarcinoma\nCRISPR gene effect (Chronos): -0.009\nDependency probability: 0.020\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "GLT6D1", "model_id": "ACH-000932", "lineage": "Esophagus/Stomach", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1297}}
+{"question_id": "GEL3-0043", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: IL36RN\nCell line: RL952_ENDOMETRIUM\nLineage: Uterus\nDisease: Endometrial Carcinoma\nCRISPR gene effect (Chronos): 0.113\nDependency probability: 0.005\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "IL36RN", "model_id": "ACH-000965", "lineage": "Uterus", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1340}}
+{"question_id": "GEL3-0044", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: GCM2\nCell line: NCIH2452_PLEURA\nLineage: Pleura\nDisease: Pleural Mesothelioma\nCRISPR gene effect (Chronos): -0.093\nDependency probability: 0.063\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1218 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "GCM2", "model_id": "ACH-000092", "lineage": "Pleura", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1218}}
+{"question_id": "GEL3-0045", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: GHRH\nCell line: TC106_BONE\nLineage: Bone\nDisease: Ewing Sarcoma\nCRISPR gene effect (Chronos): 0.025\nDependency probability: 0.011\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "GHRH", "model_id": "ACH-001283", "lineage": "Bone", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1340}, "gold_reasoning": "GHRH is described as: growth hormone releasing hormone. In TC106_BONE (Bone), CRISPR knockout of GHRH shows no significant effect on cell viability. GHRH is part of the reference non-essential gene set, indicating it is dispensable for cell survival across multiple cell types and screening contexts. GHRH is non-essential in 1340 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (0.025) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0046", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TBR1\nCell line: NCIH1648_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): -0.199\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "TBR1", "model_id": "ACH-000766", "lineage": "Lung", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1340}}
+{"question_id": "GEL3-0047", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR2T4\nCell line: SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Lymphoid\nDisease: Mature T and NK Neoplasms\nCRISPR gene effect (Chronos): -0.054\nDependency probability: 0.038\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1261 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR2T4", "model_id": "ACH-000664", "lineage": "Lymphoid", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1261}}
+{"question_id": "GEL3-0048", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: NLRP9\nCell line: OC316_OVARY\nLineage: Ovary/Fallopian Tube\nDisease: Ovarian Epithelial Tumor\nCRISPR gene effect (Chronos): -0.063\nDependency probability: 0.035\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "NLRP9", "model_id": "ACH-001145", "lineage": "Ovary/Fallopian Tube", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1258}}
+{"question_id": "GEL3-0049", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: KIR3DL3\nCell line: HRT18_LARGE_INTESTINE\nLineage: Bowel\nDisease: Colorectal Adenocarcinoma\nCRISPR gene effect (Chronos): 0.354\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "KIR3DL3", "model_id": "ACH-001091", "lineage": "Bowel", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1341}}
+{"question_id": "GEL3-0050", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: CYP2A13\nCell line: NZM42_SKIN\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): -0.255\nDependency probability: 0.154\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1175 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "CYP2A13", "model_id": "ACH-001986", "lineage": "Skin", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1175}}
+{"question_id": "GEL3-0051", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: RXFP3\nCell line: HLE_LIVER\nLineage: Liver\nDisease: Hepatocellular Carcinoma\nCRISPR gene effect (Chronos): 0.005\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "RXFP3", "model_id": "ACH-001089", "lineage": "Liver", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1340}}
+{"question_id": "GEL3-0052", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: IL1F10\nCell line: SKNBE2_AUTONOMIC_GANGLIA\nLineage: Peripheral Nervous System\nDisease: Neuroblastoma\nCRISPR gene effect (Chronos): 0.071\nDependency probability: 0.008\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1294 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "IL1F10", "model_id": "ACH-000312", "lineage": "Peripheral Nervous System", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1294}}
+{"question_id": "GEL3-0053", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: GARIN3\nCell line: 786O_KIDNEY\nLineage: Kidney\nDisease: Renal Cell Carcinoma\nCRISPR gene effect (Chronos): -0.061\nDependency probability: 0.042\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "GARIN3", "model_id": "ACH-000649", "lineage": "Kidney", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1258}}
+{"question_id": "GEL3-0054", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR4D10\nCell line: CORL23_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): -0.272\nDependency probability: 0.148\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR4D10", "model_id": "ACH-000662", "lineage": "Lung", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1208}}
+{"question_id": "GEL3-0055", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: OR2T4\nCell line: MPP89_PLEURA\nLineage: Pleura\nDisease: Pleural Mesothelioma\nCRISPR gene effect (Chronos): -0.252\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1261 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR2T4", "model_id": "ACH-000319", "lineage": "Pleura", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1261}}
+{"question_id": "GEL3-0056", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: PRG3\nCell line: SG231_BILIARY_TRACT\nLineage: Biliary Tract\nDisease: Intraductal Papillary Neoplasm of the Bile Duct\nCRISPR gene effect (Chronos): -0.194\nDependency probability: 0.079\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "PRG3", "model_id": "ACH-001857", "lineage": "Biliary Tract", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1297}, "gold_reasoning": "PRG3 is described as: proteoglycan 3, pro eosinophil major basic protein 2. In SG231_BILIARY_TRACT (Biliary Tract), CRISPR knockout of PRG3 shows no significant effect on cell viability. PRG3 is part of the reference non-essential gene set, indicating it is dispensable for cell survival across multiple cell types and screening contexts. PRG3 is non-essential in 1297 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (-0.194) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0057", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: KRTAP11-1\nCell line: SW1271_LUNG\nLineage: Lung\nDisease: SMARCA4-deficient undifferentiated tumor\nCRISPR gene effect (Chronos): 0.087\nDependency probability: 0.013\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "KRTAP11-1", "model_id": "ACH-000890", "lineage": "Lung", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1258}}
+{"question_id": "GEL3-0058", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: GPR151\nCell line: KYM1_SOFT_TISSUE\nLineage: Kidney\nDisease: Rhabdoid Cancer\nCRISPR gene effect (Chronos): -0.249\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "GPR151", "model_id": "ACH-000607", "lineage": "Kidney", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1340}}
+{"question_id": "GEL3-0059", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR52K2\nCell line: NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Lymphoid\nDisease: Mature B-Cell Neoplasms\nCRISPR gene effect (Chronos): 0.246\nDependency probability: 0.001\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR52K2", "model_id": "ACH-000944", "lineage": "Lymphoid", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1208}}
+{"question_id": "GEL3-0060", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: TRIM60\nCell line: PC3_PROSTATE\nLineage: Prostate\nDisease: Prostate Adenocarcinoma\nCRISPR gene effect (Chronos): 0.105\nDependency probability: 0.008\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "TRIM60", "model_id": "ACH-000090", "lineage": "Prostate", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1297}}
+{"question_id": "GEL3-0061", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR8A1\nCell line: MM383_SKIN\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): -0.180\nDependency probability: 0.083\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1204 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR8A1", "model_id": "ACH-001567", "lineage": "Skin", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1204}}
+{"question_id": "GEL3-0062", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: C10orf120\nCell line: 8MGBA_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): -0.016\nDependency probability: 0.024\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "C10orf120", "model_id": "ACH-000137", "lineage": "CNS/Brain", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1258}}
+{"question_id": "GEL3-0063", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: GUCA2A\nCell line: WM88_SKIN\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): -0.096\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1293 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "GUCA2A", "model_id": "ACH-000899", "lineage": "Skin", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1293}}
+{"question_id": "GEL3-0064", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR2T4\nCell line: TUHR10TKB_KIDNEY\nLineage: Kidney\nDisease: Renal Cell Carcinoma\nCRISPR gene effect (Chronos): 0.203\nDependency probability: 0.019\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1261 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR2T4", "model_id": "ACH-000459", "lineage": "Kidney", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1261}}
+{"question_id": "GEL3-0065", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: SOX1\nCell line: M040416_SKIN\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): 0.192\nDependency probability: 0.003\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1338 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "SOX1", "model_id": "ACH-002510", "lineage": "Skin", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1338}}
+{"question_id": "GEL3-0066", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: MAS1\nCell line: NCIH292_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): 0.134\nDependency probability: 0.004\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "MAS1", "model_id": "ACH-001075", "lineage": "Lung", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1341}, "gold_reasoning": "MAS1 is described as: MAS1 proto-oncogene, G protein-coupled receptor. In NCIH292_LUNG (Lung), CRISPR knockout of MAS1 shows no significant effect on cell viability. MAS1 is part of the reference non-essential gene set, indicating it is dispensable for cell survival across multiple cell types and screening contexts. MAS1 is non-essential in 1341 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (0.134) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0067", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: OR10Z1\nCell line: HEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Myeloid\nDisease: Acute Myeloid Leukemia\nCRISPR gene effect (Chronos): 0.106\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR10Z1", "model_id": "ACH-000004", "lineage": "Myeloid", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1208}}
+{"question_id": "GEL3-0068", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: OR5P3\nCell line: NCIH841_LUNG\nLineage: Lung\nDisease: SMARCA4-deficient undifferentiated tumor\nCRISPR gene effect (Chronos): 0.033\nDependency probability: 0.010\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR5P3", "model_id": "ACH-000292", "lineage": "Lung", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1208}, "gold_reasoning": "OR5P3 is described as: olfactory receptor family 5 subfamily P member 3. In NCIH841_LUNG (Lung), CRISPR knockout of OR5P3 shows no significant effect on cell viability. OR5P3 is part of the reference non-essential gene set, indicating it is dispensable for cell survival across multiple cell types and screening contexts. OR5P3 is non-essential in 1208 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (0.033) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0069", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: KRTAP4-4\nCell line: HCC1143_BREAST\nLineage: Breast\nDisease: Invasive Breast Carcinoma\nCRISPR gene effect (Chronos): 0.027\nDependency probability: 0.017\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1133 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "KRTAP4-4", "model_id": "ACH-000374", "lineage": "Breast", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1133}, "gold_reasoning": "KRTAP4-4 is described as: keratin associated protein 4-4. In HCC1143_BREAST (Breast), CRISPR knockout of KRTAP4-4 shows no significant effect on cell viability. KRTAP4-4 is part of the reference non-essential gene set, indicating it is dispensable for cell survival across multiple cell types and screening contexts. KRTAP4-4 is non-essential in 1133 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (0.027) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0070", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: ALPI\nCell line: LOUNH91_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): 0.195\nDependency probability: 0.013\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "ALPI", "model_id": "ACH-000176", "lineage": "Lung", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1340}}
+{"question_id": "GEL3-0071", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR51B6\nCell line: SNU449_LIVER\nLineage: Liver\nDisease: Hepatocellular Carcinoma\nCRISPR gene effect (Chronos): 0.016\nDependency probability: 0.018\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR51B6", "model_id": "ACH-000420", "lineage": "Liver", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1208}}
+{"question_id": "GEL3-0072", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR52L1\nCell line: M040416_SKIN\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): -0.059\nDependency probability: 0.027\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR52L1", "model_id": "ACH-002510", "lineage": "Skin", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1208}}
+{"question_id": "GEL3-0073", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: KRTAP17-1\nCell line: NP2_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): -0.043\nDependency probability: 0.036\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1256 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "KRTAP17-1", "model_id": "ACH-001608", "lineage": "CNS/Brain", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1256}}
+{"question_id": "GEL3-0074", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: HTR3D\nCell line: YSCCC_BILIARY_TRACT\nLineage: Biliary Tract\nDisease: Intraductal Papillary Neoplasm of the Bile Duct\nCRISPR gene effect (Chronos): 0.255\nDependency probability: 0.001\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "HTR3D", "model_id": "ACH-001864", "lineage": "Biliary Tract", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1341}}
+{"question_id": "GEL3-0075", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: HTR3C\nCell line: HCC515_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): 0.234\nDependency probability: 0.003\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "HTR3C", "model_id": "ACH-000872", "lineage": "Lung", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1341}}
+{"question_id": "GEL3-0076", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: PBOV1\nCell line: CHL1DM_SKIN\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): 0.230\nDependency probability: 0.001\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "PBOV1", "model_id": "ACH-001041", "lineage": "Skin", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1258}}
+{"question_id": "GEL3-0077", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: BPIFB6\nCell line: KIJK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Lymphoid\nDisease: Mature T and NK Neoplasms\nCRISPR gene effect (Chronos): -0.022\nDependency probability: 0.031\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1257 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "BPIFB6", "model_id": "ACH-000773", "lineage": "Lymphoid", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1257}}
+{"question_id": "GEL3-0078", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: KCNV1\nCell line: nan\nLineage: Soft Tissue\nDisease: Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma/High-Grade Spindle Cell Sarcoma\nCRISPR gene effect (Chronos): 0.007\nDependency probability: 0.023\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "KCNV1", "model_id": "ACH-002782", "lineage": "Soft Tissue", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1341}, "gold_reasoning": "KCNV1 is described as: potassium voltage-gated channel modifier subfamily V member 1. In nan (Soft Tissue), CRISPR knockout of KCNV1 shows no significant effect on cell viability. KCNV1 is part of the reference non-essential gene set, indicating it is dispensable for cell survival across multiple cell types and screening contexts. KCNV1 is non-essential in 1341 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (0.007) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0079", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR1A1\nCell line: G361_SKIN\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): -0.056\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR1A1", "model_id": "ACH-000572", "lineage": "Skin", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1208}}
+{"question_id": "GEL3-0080", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR52K2\nCell line: PC14_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): 0.151\nDependency probability: 0.005\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR52K2", "model_id": "ACH-000030", "lineage": "Lung", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1208}}
+{"question_id": "GEL3-0081", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SLC2A7\nCell line: EFO21_OVARY\nLineage: Ovary/Fallopian Tube\nDisease: Ovarian Epithelial Tumor\nCRISPR gene effect (Chronos): -0.104\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "SLC2A7", "model_id": "ACH-000308", "lineage": "Ovary/Fallopian Tube", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1297}}
+{"question_id": "GEL3-0082", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: TAAR2\nCell line: NUGC3_STOMACH\nLineage: Esophagus/Stomach\nDisease: Esophagogastric Adenocarcinoma\nCRISPR gene effect (Chronos): 0.057\nDependency probability: 0.008\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1338 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "TAAR2", "model_id": "ACH-000911", "lineage": "Esophagus/Stomach", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1338}, "gold_reasoning": "TAAR2 is described as: trace amine associated receptor 2. In NUGC3_STOMACH (Esophagus/Stomach), CRISPR knockout of TAAR2 shows no significant effect on cell viability. TAAR2 is part of the reference non-essential gene set, indicating it is dispensable for cell survival across multiple cell types and screening contexts. TAAR2 is non-essential in 1338 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (0.057) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0083", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: C10orf120\nCell line: SW837_LARGE_INTESTINE\nLineage: Bowel\nDisease: Colorectal Adenocarcinoma\nCRISPR gene effect (Chronos): -0.107\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "C10orf120", "model_id": "ACH-000421", "lineage": "Bowel", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1258}}
+{"question_id": "GEL3-0084", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: CLEC2A\nCell line: KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Lymphoid\nDisease: Mature B-Cell Neoplasms\nCRISPR gene effect (Chronos): 0.043\nDependency probability: 0.013\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "CLEC2A", "model_id": "ACH-000315", "lineage": "Lymphoid", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1258}}
+{"question_id": "GEL3-0085", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TBR1\nCell line: HEC59_ENDOMETRIUM\nLineage: Uterus\nDisease: Endometrial Carcinoma\nCRISPR gene effect (Chronos): 0.016\nDependency probability: 0.016\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "TBR1", "model_id": "ACH-000994", "lineage": "Uterus", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1340}}
+{"question_id": "GEL3-0086", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: ALPG\nCell line: KMM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Lymphoid\nDisease: Mature B-Cell Neoplasms\nCRISPR gene effect (Chronos): 0.013\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1322 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "ALPG", "model_id": "ACH-000889", "lineage": "Lymphoid", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1322}}
+{"question_id": "GEL3-0087", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: CYP7A1\nCell line: MERO41_PLEURA\nLineage: Pleura\nDisease: Pleural Mesothelioma\nCRISPR gene effect (Chronos): 0.098\nDependency probability: 0.009\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "CYP7A1", "model_id": "ACH-001557", "lineage": "Pleura", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1340}}
+{"question_id": "GEL3-0088", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: IFIT1B\nCell line: U118MG_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): 0.033\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1256 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "IFIT1B", "model_id": "ACH-000040", "lineage": "CNS/Brain", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1256}}
+{"question_id": "GEL3-0089", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR1E1\nCell line: JHH5_LIVER\nLineage: Liver\nDisease: Hepatocellular Carcinoma\nCRISPR gene effect (Chronos): -0.008\nDependency probability: 0.022\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1205 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR1E1", "model_id": "ACH-000734", "lineage": "Liver", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1205}}
+{"question_id": "GEL3-0090", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SLC13A1\nCell line: 170MGBA_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): 0.079\nDependency probability: 0.013\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "SLC13A1", "model_id": "ACH-002680", "lineage": "CNS/Brain", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1297}}
+{"question_id": "GEL3-0091", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: ASB17\nCell line: SNUC4_LARGE_INTESTINE\nLineage: Bowel\nDisease: Colorectal Adenocarcinoma\nCRISPR gene effect (Chronos): 0.024\nDependency probability: 0.009\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "ASB17", "model_id": "ACH-000959", "lineage": "Bowel", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1258}}
+{"question_id": "GEL3-0092", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR6V1\nCell line: PANC0813_PANCREAS\nLineage: Pancreas\nDisease: Pancreatic Adenocarcinoma\nCRISPR gene effect (Chronos): 0.032\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "OR6V1", "model_id": "ACH-000417", "lineage": "Pancreas", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1208}}
+{"question_id": "GEL3-0093", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: TAAR6\nCell line: SET2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Myeloid\nDisease: Acute Myeloid Leukemia\nCRISPR gene effect (Chronos): 0.260\nDependency probability: 0.002\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "TAAR6", "model_id": "ACH-000195", "lineage": "Myeloid", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1341}}
+{"question_id": "GEL3-0094", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SLC22A8\nCell line: PECAPJ34CLONEC12_UPPER_AERODIGESTIVE_TRACT\nLineage: Head and Neck\nDisease: Head and Neck Squamous Cell Carcinoma\nCRISPR gene effect (Chronos): -0.264\nDependency probability: 0.166\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1296 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "SLC22A8", "model_id": "ACH-000606", "lineage": "Head and Neck", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1296}}
+{"question_id": "GEL3-0095", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: KRTAP4-4\nCell line: HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Lymphoid\nDisease: Mature B-Cell Neoplasms\nCRISPR gene effect (Chronos): -0.198\nDependency probability: 0.092\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1133 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "KRTAP4-4", "model_id": "ACH-000829", "lineage": "Lymphoid", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1133}, "gold_reasoning": "KRTAP4-4 is described as: keratin associated protein 4-4. In HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid), CRISPR knockout of KRTAP4-4 shows no significant effect on cell viability. KRTAP4-4 is part of the reference non-essential gene set, indicating it is dispensable for cell survival across multiple cell types and screening contexts. KRTAP4-4 is non-essential in 1133 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (-0.198) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0096", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: KRTAP19-3\nCell line: TE8_OESOPHAGUS\nLineage: Esophagus/Stomach\nDisease: Esophageal Squamous Cell Carcinoma\nCRISPR gene effect (Chronos): -0.094\nDependency probability: 0.076\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1131 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "KRTAP19-3", "model_id": "ACH-000452", "lineage": "Esophagus/Stomach", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1131}}
+{"question_id": "GEL3-0097", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TMPRSS11A\nCell line: NCIH1581_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): -0.118\nDependency probability: 0.049\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "TMPRSS11A", "model_id": "ACH-000015", "lineage": "Lung", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1297}}
+{"question_id": "GEL3-0098", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: KRTAP10-2\nCell line: NCIH1650_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): 0.307\nDependency probability: 0.001\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1153 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "KRTAP10-2", "model_id": "ACH-000035", "lineage": "Lung", "confidence_tier": "gold", "is_reference_nonessential": 1, "gene_degree": 1153}}
+{"question_id": "GEL3-0099", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: PNPLA5\nCell line: QGP1_PANCREAS\nLineage: Pancreas\nDisease: Pancreatic Neuroendocrine Tumor\nCRISPR gene effect (Chronos): -0.013\nThis gene is in the reference non-essential gene set (Hart et al.)\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "rnai_nonessential", "gold_category": "reference", "metadata": {"gene_symbol": "PNPLA5", "model_id": "ACH-000347", "lineage": "Pancreas", "confidence_tier": "silver", "is_reference_nonessential": 1, "gene_degree": 1297}}
+{"question_id": "GEL3-0100", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: GTF2I\nCell line: C4II_CERVIX\nLineage: Cervix\nDisease: Cervical Squamous Cell Carcinoma\nCRISPR gene effect (Chronos): -0.400\nDependency probability: 0.370\nNon-essential in 1339 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "GTF2I", "model_id": "ACH-001335", "lineage": "Cervix", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1339}}
+{"question_id": "GEL3-0101", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: MINPP1\nCell line: KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Lymphoid\nDisease: Mature B-Cell Neoplasms\nCRISPR gene effect (Chronos): -0.187\nDependency probability: 0.076\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "MINPP1", "model_id": "ACH-000315", "lineage": "Lymphoid", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1297}}
+{"question_id": "GEL3-0102", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: FAM178B\nCell line: P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Myeloid\nDisease: Acute Myeloid Leukemia\nCRISPR gene effect (Chronos): -0.071\nDependency probability: 0.041\nNon-essential in 1231 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "FAM178B", "model_id": "ACH-000770", "lineage": "Myeloid", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1231}}
+{"question_id": "GEL3-0103", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: FRYL\nCell line: U87MG_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): 0.137\nDependency probability: 0.010\nNon-essential in 1260 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "FRYL", "model_id": "ACH-000075", "lineage": "CNS/Brain", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1260}}
+{"question_id": "GEL3-0104", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: COX7C\nCell line: TE1_OESOPHAGUS\nLineage: Esophagus/Stomach\nDisease: Esophageal Squamous Cell Carcinoma\nCRISPR gene effect (Chronos): -0.734\nDependency probability: 0.883\nNon-essential in 994 cell lines in DepMap", "gold_answer": "multi_screen_concordant", "gold_category": "context", "metadata": {"gene_symbol": "COX7C", "model_id": "ACH-000647", "lineage": "Esophagus/Stomach", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 994}}
+{"question_id": "GEL3-0105", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: MARCHF2\nCell line: HT29_LARGE_INTESTINE\nLineage: Bowel\nDisease: Colorectal Adenocarcinoma\nCRISPR gene effect (Chronos): -0.018\nDependency probability: 0.028\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "MARCHF2", "model_id": "ACH-000552", "lineage": "Bowel", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1208}}
+{"question_id": "GEL3-0106", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: GPR160\nCell line: SNU638_STOMACH\nLineage: Esophagus/Stomach\nDisease: Esophagogastric Adenocarcinoma\nCRISPR gene effect (Chronos): 0.051\nDependency probability: 0.011\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "GPR160", "model_id": "ACH-001664", "lineage": "Esophagus/Stomach", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}}
+{"question_id": "GEL3-0107", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: CNTNAP4\nCell line: ISHIKAWAHERAKLIO02ER_ENDOMETRIUM\nLineage: Uterus\nDisease: Endometrial Carcinoma\nCRISPR gene effect (Chronos): 0.183\nDependency probability: 0.002\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "CNTNAP4", "model_id": "ACH-000961", "lineage": "Uterus", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1258}}
+{"question_id": "GEL3-0108", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: PGGHG\nCell line: MFE296_ENDOMETRIUM\nLineage: Uterus\nDisease: Endometrial Carcinoma\nCRISPR gene effect (Chronos): 0.096\nDependency probability: 0.014\nNon-essential in 1186 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "PGGHG", "model_id": "ACH-000879", "lineage": "Uterus", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1186}}
+{"question_id": "GEL3-0109", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: RERG\nCell line: BHY_UPPER_AERODIGESTIVE_TRACT\nLineage: Head and Neck\nDisease: Head and Neck Squamous Cell Carcinoma\nCRISPR gene effect (Chronos): -0.275\nDependency probability: 0.237\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "RERG", "model_id": "ACH-000548", "lineage": "Head and Neck", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}}
+{"question_id": "GEL3-0110", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SIDT1\nCell line: THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Myeloid\nDisease: Acute Myeloid Leukemia\nCRISPR gene effect (Chronos): 0.129\nDependency probability: 0.009\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "SIDT1", "model_id": "ACH-000146", "lineage": "Myeloid", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1258}}
+{"question_id": "GEL3-0111", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: CCDC125\nCell line: MCC26_SKIN\nLineage: Skin\nDisease: Merkel Cell Carcinoma\nCRISPR gene effect (Chronos): -0.386\nDependency probability: 0.229\nNon-essential in 1186 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "CCDC125", "model_id": "ACH-001552", "lineage": "Skin", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1186}}
+{"question_id": "GEL3-0112", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TNFRSF17\nCell line: KMRC2_KIDNEY\nLineage: Kidney\nDisease: Renal Cell Carcinoma\nCRISPR gene effect (Chronos): -0.206\nDependency probability: 0.086\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "TNFRSF17", "model_id": "ACH-000709", "lineage": "Kidney", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1341}}
+{"question_id": "GEL3-0113", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: COL9A2\nCell line: MOLM14_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Myeloid\nDisease: Acute Myeloid Leukemia\nCRISPR gene effect (Chronos): -0.139\nDependency probability: 0.071\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "COL9A2", "model_id": "ACH-001574", "lineage": "Myeloid", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1341}}
+{"question_id": "GEL3-0114", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: CIB3\nCell line: KP363T_COLON\nLineage: Bowel\nDisease: Colorectal Adenocarcinoma\nCRISPR gene effect (Chronos): 0.013\nDependency probability: 0.021\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "CIB3", "model_id": "ACH-002669", "lineage": "Bowel", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1297}}
+{"question_id": "GEL3-0115", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: GABBR2\nCell line: NB5_AUTONOMIC_GANGLIA\nLineage: Peripheral Nervous System\nDisease: Neuroblastoma\nCRISPR gene effect (Chronos): -0.072\nDependency probability: 0.037\nNon-essential in 1339 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "GABBR2", "model_id": "ACH-002283", "lineage": "Peripheral Nervous System", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1339}, "gold_reasoning": "GABBR2 is described as: gamma-aminobutyric acid type B receptor subunit 2. In NB5_AUTONOMIC_GANGLIA (Peripheral Nervous System), CRISPR knockout of GABBR2 shows no significant effect on cell viability. GABBR2 is non-essential in 1339 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (-0.072) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0116", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: PRELP\nCell line: PACADD165_PANCREAS\nLineage: Pancreas\nDisease: Pancreatic Adenocarcinoma\nCRISPR gene effect (Chronos): -0.069\nDependency probability: 0.041\nNon-essential in 1317 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "PRELP", "model_id": "ACH-001380", "lineage": "Pancreas", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1317}}
+{"question_id": "GEL3-0117", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: NSD3\nCell line: EPLC272H_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): 0.007\nDependency probability: 0.028\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "NSD3", "model_id": "ACH-000585", "lineage": "Lung", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}}
+{"question_id": "GEL3-0118", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SRMS\nCell line: SCLC22H_LUNG\nLineage: Lung\nDisease: Lung Neuroendocrine Tumor\nCRISPR gene effect (Chronos): -0.090\nDependency probability: 0.045\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "SRMS", "model_id": "ACH-001386", "lineage": "Lung", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}}
+{"question_id": "GEL3-0119", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OAZ1\nCell line: TKKK_BILIARY_TRACT\nLineage: Biliary Tract\nDisease: Intraductal Papillary Neoplasm of the Bile Duct\nCRISPR gene effect (Chronos): -0.306\nDependency probability: 0.211\nNon-essential in 1296 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "OAZ1", "model_id": "ACH-001863", "lineage": "Biliary Tract", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1296}}
+{"question_id": "GEL3-0120", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: FMR1\nCell line: HMC18_BREAST\nLineage: Breast\nDisease: Invasive Breast Carcinoma\nCRISPR gene effect (Chronos): 0.029\nDependency probability: 0.017\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "FMR1", "model_id": "ACH-000721", "lineage": "Breast", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}}
+{"question_id": "GEL3-0121", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: UAP1L1\nCell line: OVTOKO_OVARY\nLineage: Ovary/Fallopian Tube\nDisease: Ovarian Epithelial Tumor\nCRISPR gene effect (Chronos): 0.089\nDependency probability: 0.010\nNon-essential in 1257 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "UAP1L1", "model_id": "ACH-000663", "lineage": "Ovary/Fallopian Tube", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1257}}
+{"question_id": "GEL3-0122", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: ALDH1A3\nCell line: SLR24_KIDNEY\nLineage: Kidney\nDisease: Renal Cell Carcinoma\nCRISPR gene effect (Chronos): 0.190\nDependency probability: 0.005\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "ALDH1A3", "model_id": "ACH-000272", "lineage": "Kidney", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1341}}
+{"question_id": "GEL3-0123", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: IER5L\nCell line: LN235_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): 0.218\nDependency probability: 0.003\nNon-essential in 1185 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "IER5L", "model_id": "ACH-000591", "lineage": "CNS/Brain", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1185}}
+{"question_id": "GEL3-0124", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: CHST14\nCell line: SCLC22H_LUNG\nLineage: Lung\nDisease: Lung Neuroendocrine Tumor\nCRISPR gene effect (Chronos): -0.028\nDependency probability: 0.026\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "CHST14", "model_id": "ACH-001386", "lineage": "Lung", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1297}}
+{"question_id": "GEL3-0125", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: CFAP221\nCell line: SW954_CERVIX\nLineage: Vulva/Vagina\nDisease: Squamous Cell Carcinoma of the Vulva/Vagina\nCRISPR gene effect (Chronos): -0.243\nDependency probability: 0.115\nNon-essential in 1186 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "CFAP221", "model_id": "ACH-001400", "lineage": "Vulva/Vagina", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1186}}
+{"question_id": "GEL3-0126", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SPNS2\nCell line: LPS141_SOFT_TISSUE\nLineage: Soft Tissue\nDisease: Liposarcoma\nCRISPR gene effect (Chronos): -0.161\nDependency probability: 0.077\nNon-essential in 1186 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "SPNS2", "model_id": "ACH-001799", "lineage": "Soft Tissue", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1186}}
+{"question_id": "GEL3-0127", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: FAM83A\nCell line: JHUEM7_ENDOMETRIUM\nLineage: Uterus\nDisease: Endometrial Carcinoma\nCRISPR gene effect (Chronos): -0.082\nDependency probability: 0.044\nNon-essential in 1184 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "FAM83A", "model_id": "ACH-000993", "lineage": "Uterus", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1184}}
+{"question_id": "GEL3-0128", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: FAM98C\nCell line: FTC133_THYROID\nLineage: Thyroid\nDisease: Well-Differentiated Thyroid Cancer\nCRISPR gene effect (Chronos): -0.214\nDependency probability: 0.136\nNon-essential in 1230 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "FAM98C", "model_id": "ACH-000903", "lineage": "Thyroid", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1230}, "gold_reasoning": "FAM98C is described as: family with sequence similarity 98 member C. In FTC133_THYROID (Thyroid), CRISPR knockout of FAM98C shows no significant effect on cell viability. FAM98C is non-essential in 1230 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance."}
+{"question_id": "GEL3-0129", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: DAPK3\nCell line: JHU011_UPPER_AERODIGESTIVE_TRACT\nLineage: Head and Neck\nDisease: Head and Neck Squamous Cell Carcinoma\nCRISPR gene effect (Chronos): 0.165\nDependency probability: 0.005\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "DAPK3", "model_id": "ACH-002249", "lineage": "Head and Neck", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1341}}
+{"question_id": "GEL3-0130", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: PLAA\nCell line: GP5D_LARGE_INTESTINE\nLineage: Bowel\nDisease: Colorectal Adenocarcinoma\nCRISPR gene effect (Chronos): -0.084\nDependency probability: 0.047\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "PLAA", "model_id": "ACH-001345", "lineage": "Bowel", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}}
+{"question_id": "GEL3-0131", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OR2B3\nCell line: SISO_CERVIX\nLineage: Cervix\nDisease: Cervical Adenocarcinoma\nCRISPR gene effect (Chronos): -0.083\nDependency probability: 0.046\nNon-essential in 1067 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "OR2B3", "model_id": "ACH-001650", "lineage": "Cervix", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1067}}
+{"question_id": "GEL3-0132", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: ARHGAP25\nCell line: L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Lymphoid\nDisease: Mature B-Cell Neoplasms\nCRISPR gene effect (Chronos): 0.038\nDependency probability: 0.011\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "ARHGAP25", "model_id": "ACH-000183", "lineage": "Lymphoid", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}}
+{"question_id": "GEL3-0133", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: MAPKBP1\nCell line: MERO25_PLEURA\nLineage: Pleura\nDisease: Pleural Mesothelioma\nCRISPR gene effect (Chronos): 0.021\nDependency probability: 0.017\nNon-essential in 1339 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "MAPKBP1", "model_id": "ACH-001556", "lineage": "Pleura", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1339}}
+{"question_id": "GEL3-0134", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: ADAM29\nCell line: JMSU1_URINARY_TRACT\nLineage: Bladder/Urinary Tract\nDisease: Bladder Urothelial Carcinoma\nCRISPR gene effect (Chronos): 0.061\nDependency probability: 0.013\nNon-essential in 1296 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "ADAM29", "model_id": "ACH-000753", "lineage": "Bladder/Urinary Tract", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1296}}
+{"question_id": "GEL3-0135", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: OR10G2\nCell line: MCF7_BREAST\nLineage: Breast\nDisease: Invasive Breast Carcinoma\nCRISPR gene effect (Chronos): -0.086\nDependency probability: 0.033\nNon-essential in 1140 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "OR10G2", "model_id": "ACH-000019", "lineage": "Breast", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1140}}
+{"question_id": "GEL3-0136", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SLC22A3\nCell line: LK2_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): 0.098\nDependency probability: 0.006\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "SLC22A3", "model_id": "ACH-000769", "lineage": "Lung", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1341}}
+{"question_id": "GEL3-0137", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: CXCR6\nCell line: SW1573_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): 0.162\nDependency probability: 0.005\nNon-essential in 1186 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "CXCR6", "model_id": "ACH-000677", "lineage": "Lung", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1186}}
+{"question_id": "GEL3-0138", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OS9\nCell line: SKPNDW_BONE\nLineage: Bone\nDisease: Ewing Sarcoma\nCRISPR gene effect (Chronos): -0.232\nDependency probability: 0.103\nNon-essential in 1312 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "OS9", "model_id": "ACH-001193", "lineage": "Bone", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1312}}
+{"question_id": "GEL3-0139", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: CFAP43\nCell line: RPMI2650_UPPER_AERODIGESTIVE_TRACT\nLineage: Head and Neck\nDisease: Head and Neck Carcinoma, Other\nCRISPR gene effect (Chronos): -0.063\nDependency probability: 0.033\nNon-essential in 1186 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "CFAP43", "model_id": "ACH-001385", "lineage": "Head and Neck", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1186}}
+{"question_id": "GEL3-0140", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: AHSA1\nCell line: BICR10_UPPER_AERODIGESTIVE_TRACT\nLineage: Head and Neck\nDisease: Head and Neck Squamous Cell Carcinoma\nCRISPR gene effect (Chronos): 0.001\nDependency probability: 0.023\nNon-essential in 1256 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "AHSA1", "model_id": "ACH-001331", "lineage": "Head and Neck", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1256}}
+{"question_id": "GEL3-0141", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: PTPN2\nCell line: DBTRG05MG_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): 0.027\nDependency probability: 0.019\nNon-essential in 1286 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "PTPN2", "model_id": "ACH-000863", "lineage": "CNS/Brain", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1286}}
+{"question_id": "GEL3-0142", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: POU2AF1\nCell line: RMGI_OVARY\nLineage: Ovary/Fallopian Tube\nDisease: Ovarian Epithelial Tumor\nCRISPR gene effect (Chronos): -0.129\nDependency probability: 0.100\nNon-essential in 1318 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "POU2AF1", "model_id": "ACH-000719", "lineage": "Ovary/Fallopian Tube", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1318}}
+{"question_id": "GEL3-0143", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: FXYD3\nCell line: ES2_OVARY\nLineage: Ovary/Fallopian Tube\nDisease: Ovarian Epithelial Tumor\nCRISPR gene effect (Chronos): -0.015\nDependency probability: 0.023\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "FXYD3", "model_id": "ACH-000906", "lineage": "Ovary/Fallopian Tube", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1341}}
+{"question_id": "GEL3-0144", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: ZBTB39\nCell line: CHP212_AUTONOMIC_GANGLIA\nLineage: Peripheral Nervous System\nDisease: Neuroblastoma\nCRISPR gene effect (Chronos): -0.167\nDependency probability: 0.081\nNon-essential in 1337 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "ZBTB39", "model_id": "ACH-000120", "lineage": "Peripheral Nervous System", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1337}}
+{"question_id": "GEL3-0145", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TRIM21\nCell line: SNU449_LIVER\nLineage: Liver\nDisease: Hepatocellular Carcinoma\nCRISPR gene effect (Chronos): -0.029\nDependency probability: 0.026\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "TRIM21", "model_id": "ACH-000420", "lineage": "Liver", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1297}}
+{"question_id": "GEL3-0146", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TTLL1\nCell line: HS852T_SKIN\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): 0.036\nDependency probability: 0.022\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "TTLL1", "model_id": "ACH-000274", "lineage": "Skin", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}}
+{"question_id": "GEL3-0147", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: FGD5\nCell line: L82_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Lymphoid\nDisease: Mature T and NK Neoplasms\nCRISPR gene effect (Chronos): -0.319\nDependency probability: 0.163\nNon-essential in 1338 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "FGD5", "model_id": "ACH-001111", "lineage": "Lymphoid", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1338}}
+{"question_id": "GEL3-0148", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: DRAXIN\nCell line: JAR_PLACENTA\nLineage: Uterus\nDisease: Gestational Trophoblastic Disease\nCRISPR gene effect (Chronos): -0.116\nDependency probability: 0.055\nNon-essential in 1257 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "DRAXIN", "model_id": "ACH-001529", "lineage": "Uterus", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1257}}
+{"question_id": "GEL3-0149", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: GPR176\nCell line: DLD1_LARGE_INTESTINE\nLineage: Bowel\nDisease: Colorectal Adenocarcinoma\nCRISPR gene effect (Chronos): 0.085\nDependency probability: 0.005\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "GPR176", "model_id": "ACH-001061", "lineage": "Bowel", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}}
+{"question_id": "GEL3-0150", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: ECHDC1\nCell line: KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Lymphoid\nDisease: Mature B-Cell Neoplasms\nCRISPR gene effect (Chronos): 0.137\nDependency probability: 0.007\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "ECHDC1", "model_id": "ACH-000714", "lineage": "Lymphoid", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1341}}
+{"question_id": "GEL3-0151", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: CHST7\nCell line: HT115_LARGE_INTESTINE\nLineage: Bowel\nDisease: Colorectal Adenocarcinoma\nCRISPR gene effect (Chronos): 0.057\nDependency probability: 0.007\nNon-essential in 1320 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "CHST7", "model_id": "ACH-000986", "lineage": "Bowel", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1320}}
+{"question_id": "GEL3-0152", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: INPP5E\nCell line: KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Myeloid\nDisease: Acute Myeloid Leukemia\nCRISPR gene effect (Chronos): -0.029\nDependency probability: 0.025\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "INPP5E", "model_id": "ACH-000498", "lineage": "Myeloid", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1341}, "gold_reasoning": "INPP5E is described as: inositol polyphosphate-5-phosphatase E. In KO52_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid), CRISPR knockout of INPP5E shows no significant effect on cell viability. INPP5E is non-essential in 1341 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (-0.029) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0153", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TIGD3\nCell line: HKGZCC_BILIARY_TRACT\nLineage: Biliary Tract\nDisease: Intraductal Papillary Neoplasm of the Bile Duct\nCRISPR gene effect (Chronos): -0.138\nDependency probability: 0.093\nNon-essential in 1185 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "TIGD3", "model_id": "ACH-001852", "lineage": "Biliary Tract", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1185}}
+{"question_id": "GEL3-0154", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: GRHL2\nCell line: LN229_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): -0.143\nDependency probability: 0.109\nNon-essential in 1280 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "GRHL2", "model_id": "ACH-000595", "lineage": "CNS/Brain", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1280}}
+{"question_id": "GEL3-0155", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: UBE2G1\nCell line: HEC6_ENDOMETRIUM\nLineage: Uterus\nDisease: Endometrial Carcinoma\nCRISPR gene effect (Chronos): 0.053\nDependency probability: 0.018\nNon-essential in 1339 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "UBE2G1", "model_id": "ACH-000984", "lineage": "Uterus", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1339}}
+{"question_id": "GEL3-0156", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: RAPGEF5\nCell line: HPAFII_PANCREAS\nLineage: Pancreas\nDisease: Pancreatic Adenocarcinoma\nCRISPR gene effect (Chronos): 0.084\nDependency probability: 0.017\nNon-essential in 1338 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "RAPGEF5", "model_id": "ACH-000094", "lineage": "Pancreas", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1338}}
+{"question_id": "GEL3-0157", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TCIM\nCell line: SF126_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): -0.177\nDependency probability: 0.095\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "TCIM", "model_id": "ACH-000609", "lineage": "CNS/Brain", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1258}}
+{"question_id": "GEL3-0158", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: SNAP25\nCell line: HUPT3_PANCREAS\nLineage: Pancreas\nDisease: Pancreatic Adenocarcinoma\nCRISPR gene effect (Chronos): -0.032\nDependency probability: 0.023\nNon-essential in 1313 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "SNAP25", "model_id": "ACH-000118", "lineage": "Pancreas", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1313}, "gold_reasoning": "SNAP25 is described as: synaptosome associated protein 25. In HUPT3_PANCREAS (Pancreas), CRISPR knockout of SNAP25 shows no significant effect on cell viability. SNAP25 is non-essential in 1313 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (-0.032) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0159", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: CLPX\nCell line: MCIXC_BONE\nLineage: Bone\nDisease: Ewing Sarcoma\nCRISPR gene effect (Chronos): -0.242\nDependency probability: 0.136\nNon-essential in 1253 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "CLPX", "model_id": "ACH-002160", "lineage": "Bone", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1253}}
+{"question_id": "GEL3-0160", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: IGSF5\nCell line: LPS853_SOFT_TISSUE\nLineage: Soft Tissue\nDisease: Liposarcoma\nCRISPR gene effect (Chronos): 0.085\nDependency probability: 0.010\nNon-essential in 1186 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "IGSF5", "model_id": "ACH-001802", "lineage": "Soft Tissue", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1186}}
+{"question_id": "GEL3-0161", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SLC11A2\nCell line: CAL62_THYROID\nLineage: Thyroid\nDisease: Anaplastic Thyroid Cancer\nCRISPR gene effect (Chronos): -0.134\nDependency probability: 0.098\nNon-essential in 1294 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "SLC11A2", "model_id": "ACH-000174", "lineage": "Thyroid", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1294}}
+{"question_id": "GEL3-0162", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: JUND\nCell line: LPS510_SOFT_TISSUE\nLineage: Soft Tissue\nDisease: Liposarcoma\nCRISPR gene effect (Chronos): 0.095\nDependency probability: 0.014\nNon-essential in 1337 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "JUND", "model_id": "ACH-001804", "lineage": "Soft Tissue", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1337}}
+{"question_id": "GEL3-0163", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: PSTPIP1\nCell line: HCC1187_BREAST\nLineage: Breast\nDisease: Invasive Breast Carcinoma\nCRISPR gene effect (Chronos): 0.058\nDependency probability: 0.015\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "PSTPIP1", "model_id": "ACH-000111", "lineage": "Breast", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1341}}
+{"question_id": "GEL3-0164", "task": "ge-l3", "split": "val", "difficulty": "medium", "context_text": "Gene: ALG13\nCell line: NCIH1915_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): -0.455\nDependency probability: 0.357\nNote: This gene is classified as common essential in other cell types\nNon-essential in 638 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "ALG13", "model_id": "ACH-000434", "lineage": "Lung", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 638}}
+{"question_id": "GEL3-0165", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: TSSC4\nCell line: LS_AUTONOMIC_GANGLIA\nLineage: Peripheral Nervous System\nDisease: Neuroblastoma\nCRISPR gene effect (Chronos): 0.107\nDependency probability: 0.009\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "TSSC4", "model_id": "ACH-001548", "lineage": "Peripheral Nervous System", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1297}, "gold_reasoning": "TSSC4 is described as: tumor suppressing subtransferable candidate 4. In LS_AUTONOMIC_GANGLIA (Peripheral Nervous System), CRISPR knockout of TSSC4 shows no significant effect on cell viability. TSSC4 is non-essential in 1297 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (0.107) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0166", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: PPP1R42\nCell line: SNU308_BILIARY_TRACT\nLineage: Biliary Tract\nDisease: Intracholecystic Papillary Neoplasm\nCRISPR gene effect (Chronos): 0.024\nDependency probability: 0.019\nNon-essential in 1255 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "PPP1R42", "model_id": "ACH-000141", "lineage": "Biliary Tract", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1255}}
+{"question_id": "GEL3-0167", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: GRPR\nCell line: HUH7_LIVER\nLineage: Liver\nDisease: Hepatocellular Carcinoma\nCRISPR gene effect (Chronos): 0.100\nDependency probability: 0.005\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "GRPR", "model_id": "ACH-000480", "lineage": "Liver", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1341}}
+{"question_id": "GEL3-0168", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: THADA\nCell line: EMTOKA_ENDOMETRIUM\nLineage: Uterus\nDisease: Endometrial Carcinoma\nCRISPR gene effect (Chronos): 0.158\nDependency probability: 0.006\nNon-essential in 1295 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "THADA", "model_id": "ACH-001495", "lineage": "Uterus", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1295}}
+{"question_id": "GEL3-0169", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TFDP3\nCell line: JMURTK2_SOFT_TISSUE\nLineage: Kidney\nDisease: Rhabdoid Cancer\nCRISPR gene effect (Chronos): -0.027\nDependency probability: 0.018\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "TFDP3", "model_id": "ACH-001532", "lineage": "Kidney", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1297}}
+{"question_id": "GEL3-0170", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: RC3H1\nCell line: LNZ308_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): -0.356\nDependency probability: 0.361\nNon-essential in 1257 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "RC3H1", "model_id": "ACH-000760", "lineage": "CNS/Brain", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1257}, "gold_reasoning": "RC3H1 is described as: ring finger and CCCH-type domains 1. In LNZ308_CENTRAL_NERVOUS_SYSTEM (CNS/Brain), CRISPR knockout of RC3H1 shows no significant effect on cell viability. RC3H1 is non-essential in 1257 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance."}
+{"question_id": "GEL3-0171", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: CMAS\nCell line: 639V_URINARY_TRACT\nLineage: Bladder/Urinary Tract\nDisease: Urethral Cancer\nCRISPR gene effect (Chronos): 0.242\nDependency probability: 0.002\nNon-essential in 1291 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "CMAS", "model_id": "ACH-000973", "lineage": "Bladder/Urinary Tract", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1291}}
+{"question_id": "GEL3-0172", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: PPP1R9A\nCell line: SMZ1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Lymphoid\nDisease: Non-Hodgkin Lymphoma\nCRISPR gene effect (Chronos): 0.153\nDependency probability: 0.004\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "PPP1R9A", "model_id": "ACH-001197", "lineage": "Lymphoid", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1297}}
+{"question_id": "GEL3-0173", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: RGS5\nCell line: SNU719_STOMACH\nLineage: Esophagus/Stomach\nDisease: Esophagogastric Adenocarcinoma\nCRISPR gene effect (Chronos): -0.064\nDependency probability: 0.038\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "RGS5", "model_id": "ACH-000898", "lineage": "Esophagus/Stomach", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}}
+{"question_id": "GEL3-0174", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: HOOK2\nCell line: CHP212_AUTONOMIC_GANGLIA\nLineage: Peripheral Nervous System\nDisease: Neuroblastoma\nCRISPR gene effect (Chronos): 0.235\nDependency probability: 0.002\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "HOOK2", "model_id": "ACH-000120", "lineage": "Peripheral Nervous System", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1258}, "gold_reasoning": "HOOK2 is described as: hook microtubule tethering protein 2. In CHP212_AUTONOMIC_GANGLIA (Peripheral Nervous System), CRISPR knockout of HOOK2 shows no significant effect on cell viability. HOOK2 is non-essential in 1258 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (0.235) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0175", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: MYMK\nCell line: NCCMPNST3C1_MPNST\nLineage: Peripheral Nervous System\nDisease: Nerve Sheath Tumor\nCRISPR gene effect (Chronos): -0.006\nDependency probability: 0.026\nNon-essential in 1186 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "MYMK", "model_id": "ACH-002801", "lineage": "Peripheral Nervous System", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1186}}
+{"question_id": "GEL3-0176", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: ARMCX4\nCell line: SCH_STOMACH\nLineage: Other\nDisease: Extra Gonadal Germ Cell Tumor\nCRISPR gene effect (Chronos): 0.071\nDependency probability: 0.013\nNon-essential in 1186 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "ARMCX4", "model_id": "ACH-002198", "lineage": "Other", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1186}}
+{"question_id": "GEL3-0177", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: C4orf46\nCell line: RVH421_SKIN_FV1_RESISTANT\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): -0.012\nDependency probability: 0.029\nNon-essential in 1186 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "C4orf46", "model_id": "ACH-002461", "lineage": "Skin", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1186}, "gold_reasoning": "C4orf46 is described as: chromosome 4 open reading frame 46. In RVH421_SKIN_FV1_RESISTANT (Skin), CRISPR knockout of C4orf46 shows no significant effect on cell viability. C4orf46 is non-essential in 1186 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (-0.012) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0178", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OGFOD2\nCell line: HCC1143_BREAST\nLineage: Breast\nDisease: Invasive Breast Carcinoma\nCRISPR gene effect (Chronos): 0.095\nDependency probability: 0.009\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "OGFOD2", "model_id": "ACH-000374", "lineage": "Breast", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}}
+{"question_id": "GEL3-0179", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: KLK2\nCell line: MPNST724_SOFT_TISSUE\nLineage: Peripheral Nervous System\nDisease: Nerve Sheath Tumor\nCRISPR gene effect (Chronos): 0.013\nDependency probability: 0.027\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "KLK2", "model_id": "ACH-002710", "lineage": "Peripheral Nervous System", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}}
+{"question_id": "GEL3-0180", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: S100A9\nCell line: ACCMESO1_PLEURA\nLineage: Pleura\nDisease: Pleural Mesothelioma\nCRISPR gene effect (Chronos): -0.108\nDependency probability: 0.060\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "S100A9", "model_id": "ACH-000086", "lineage": "Pleura", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1341}}
+{"question_id": "GEL3-0181", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: PDK1\nCell line: UMRC3_KIDNEY\nLineage: Kidney\nDisease: Renal Cell Carcinoma\nCRISPR gene effect (Chronos): 0.088\nDependency probability: 0.008\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "PDK1", "model_id": "ACH-001687", "lineage": "Kidney", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1341}}
+{"question_id": "GEL3-0182", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: NFATC4\nCell line: H3118_UPPER_AERODIGESTIVE_TRACT\nLineage: Head and Neck\nDisease: Salivary Carcinoma\nCRISPR gene effect (Chronos): 0.251\nDependency probability: 0.004\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "NFATC4", "model_id": "ACH-002239", "lineage": "Head and Neck", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}, "gold_reasoning": "NFATC4 is described as: nuclear factor of activated T cells 4. In H3118_UPPER_AERODIGESTIVE_TRACT (Head and Neck), CRISPR knockout of NFATC4 shows no significant effect on cell viability. NFATC4 is non-essential in 1340 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance. The gene effect score (0.251) is close to zero, indicating minimal fitness impact upon knockout."}
+{"question_id": "GEL3-0183", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: FNDC10\nCell line: ICC8_BILIARY_TRACT\nLineage: Biliary Tract\nDisease: Intraductal Papillary Neoplasm of the Bile Duct\nCRISPR gene effect (Chronos): -0.191\nDependency probability: 0.133\nNon-essential in 1178 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "FNDC10", "model_id": "ACH-001848", "lineage": "Biliary Tract", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1178}}
+{"question_id": "GEL3-0184", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SLC18A1\nCell line: TE8_OESOPHAGUS\nLineage: Esophagus/Stomach\nDisease: Esophageal Squamous Cell Carcinoma\nCRISPR gene effect (Chronos): 0.120\nDependency probability: 0.006\nNon-essential in 1292 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "SLC18A1", "model_id": "ACH-000452", "lineage": "Esophagus/Stomach", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1292}}
+{"question_id": "GEL3-0185", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: RASGEF1A\nCell line: CAL12T_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): -0.521\nDependency probability: 0.449\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "multi_screen_concordant", "gold_category": "context", "metadata": {"gene_symbol": "RASGEF1A", "model_id": "ACH-000826", "lineage": "Lung", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}}
+{"question_id": "GEL3-0186", "task": "ge-l3", "split": "fewshot", "difficulty": "medium", "context_text": "Gene: FOSB\nCell line: NCIH358_LUNG\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): -0.250\nDependency probability: 0.156\nNon-essential in 1340 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "FOSB", "model_id": "ACH-000860", "lineage": "Lung", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1340}, "gold_reasoning": "FOSB is described as: FosB proto-oncogene, AP-1 transcription factor subunit. In NCIH358_LUNG (Lung), CRISPR knockout of FOSB shows no significant effect on cell viability. FOSB is non-essential in 1340 cell lines in DepMap, suggesting broad dispensability rather than lineage-specific tolerance."}
+{"question_id": "GEL3-0187", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: ZNG1A\nCell line: COV318_OVARY\nLineage: Ovary/Fallopian Tube\nDisease: Ovarian Epithelial Tumor\nCRISPR gene effect (Chronos): -0.232\nDependency probability: 0.124\nNon-essential in 1208 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "ZNG1A", "model_id": "ACH-000256", "lineage": "Ovary/Fallopian Tube", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1208}}
+{"question_id": "GEL3-0188", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: PSME3\nCell line: KURAMOCHI_OVARY\nLineage: Ovary/Fallopian Tube\nDisease: Ovarian Epithelial Tumor\nCRISPR gene effect (Chronos): -0.141\nDependency probability: 0.105\nNon-essential in 1287 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "PSME3", "model_id": "ACH-000524", "lineage": "Ovary/Fallopian Tube", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1287}}
+{"question_id": "GEL3-0189", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: MIDEAS\nCell line: JHH6_LIVER\nLineage: Liver\nDisease: Hepatocellular Carcinoma\nCRISPR gene effect (Chronos): -0.010\nDependency probability: 0.022\nNon-essential in 1231 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "MIDEAS", "model_id": "ACH-000217", "lineage": "Liver", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1231}}
+{"question_id": "GEL3-0190", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: ALDH8A1\nCell line: HUO9_BONE\nLineage: Bone\nDisease: Osteosarcoma\nCRISPR gene effect (Chronos): -0.114\nDependency probability: 0.048\nNon-essential in 1341 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "ALDH8A1", "model_id": "ACH-001526", "lineage": "Bone", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1341}}
+{"question_id": "GEL3-0191", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: OSBPL2\nCell line: P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE\nLineage: Myeloid\nDisease: Acute Myeloid Leukemia\nCRISPR gene effect (Chronos): -0.044\nDependency probability: 0.031\nNon-essential in 1312 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "OSBPL2", "model_id": "ACH-000770", "lineage": "Myeloid", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1312}}
+{"question_id": "GEL3-0192", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: UPRT\nCell line: HT3_CERVIX\nLineage: Cervix\nDisease: Cervical Adenocarcinoma\nCRISPR gene effect (Chronos): -0.102\nDependency probability: 0.048\nNon-essential in 1317 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "UPRT", "model_id": "ACH-001525", "lineage": "Cervix", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1317}}
+{"question_id": "GEL3-0193", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TTC31\nCell line: RKN_SOFT_TISSUE\nLineage: Soft Tissue\nDisease: Leiomyosarcoma\nCRISPR gene effect (Chronos): 0.022\nDependency probability: 0.028\nNon-essential in 1317 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "TTC31", "model_id": "ACH-000505", "lineage": "Soft Tissue", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1317}}
+{"question_id": "GEL3-0194", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: FREM1\nCell line: DKMG_CENTRAL_NERVOUS_SYSTEM\nLineage: CNS/Brain\nDisease: Diffuse Glioma\nCRISPR gene effect (Chronos): 0.061\nDependency probability: 0.016\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "FREM1", "model_id": "ACH-000244", "lineage": "CNS/Brain", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1297}}
+{"question_id": "GEL3-0195", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: TMIGD2\nCell line: RPE1SS119_ENGINEERED\nLineage: Eye\nDisease: Non-Cancerous\nCRISPR gene effect (Chronos): -0.160\nDependency probability: 0.076\nNon-essential in 1258 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "TMIGD2", "model_id": "ACH-002465", "lineage": "Eye", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1258}}
+{"question_id": "GEL3-0196", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: UBA6\nCell line: HSOS1_BONE\nLineage: Bone\nDisease: Osteosarcoma\nCRISPR gene effect (Chronos): -0.408\nDependency probability: 0.385\nNon-essential in 1311 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "UBA6", "model_id": "ACH-002069", "lineage": "Bone", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1311}}
+{"question_id": "GEL3-0197", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: C5orf34\nCell line: A549H3_Lung\nLineage: Lung\nDisease: Non-Small Cell Lung Cancer\nCRISPR gene effect (Chronos): -0.378\nDependency probability: 0.241\nNon-essential in 1257 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "C5orf34", "model_id": "ACH-003012", "lineage": "Lung", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1257}}
+{"question_id": "GEL3-0198", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: MS4A7\nCell line: KU1919_URINARY_TRACT\nLineage: Bladder/Urinary Tract\nDisease: Bladder Urothelial Carcinoma\nCRISPR gene effect (Chronos): -0.018\nDependency probability: 0.020\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "MS4A7", "model_id": "ACH-000486", "lineage": "Bladder/Urinary Tract", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1297}}
+{"question_id": "GEL3-0199", "task": "ge-l3", "split": "test", "difficulty": "medium", "context_text": "Gene: SPATS2L\nCell line: MM386_SKIN\nLineage: Skin\nDisease: Melanoma\nCRISPR gene effect (Chronos): 0.127\nDependency probability: 0.006\nNon-essential in 1297 cell lines in DepMap", "gold_answer": "crispr_nonessential", "gold_category": "context", "metadata": {"gene_symbol": "SPATS2L", "model_id": "ACH-001568", "lineage": "Skin", "confidence_tier": "silver", "is_reference_nonessential": 0, "gene_degree": 1297}}