diff --git "a/data/ge_llm/ge_l2_dataset.jsonl" "b/data/ge_llm/ge_l2_dataset.jsonl"
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+{"question_id": "GEL2-0000", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SASS6: gene effect = -0.435, dependency probability = 0.472 \u2192 classified as non-essential", "gold_answer": "SASS6", "gold_category": "depmap", "gold_extraction": {"cell_line": "P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "SASS6", "cell_line": "P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.434995967208969}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SASS6"], "cell_line": "P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0001", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OVCAR5_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PHYHIP: gene effect = 0.129, dependency probability = 0.009 \u2192 classified as non-essential", "gold_answer": "PHYHIP", "gold_category": "depmap", "gold_extraction": {"cell_line": "OVCAR5_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "PHYHIP", "cell_line": "OVCAR5_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1290113612659392}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PHYHIP"], "cell_line": "OVCAR5_OVARY"}}
+{"question_id": "GEL2-0002", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in A172_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DSN1: gene effect = -0.145, dependency probability = 0.093 \u2192 classified as non-essential\n- HSDL2: gene effect = 0.077, dependency probability = 0.005 \u2192 classified as non-essential", "gold_answer": "DSN1", "gold_category": "depmap", "gold_extraction": {"cell_line": "A172_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "DSN1", "cell_line": "A172_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1453282126283013}, {"gene_name": "HSDL2", "cell_line": "A172_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0768596266255723}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["DSN1", "HSDL2"], "cell_line": "A172_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0003", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HEC265_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FAM81B: gene effect = 0.052, dependency probability = 0.011 \u2192 classified as non-essential\n- GRK5: gene effect = 0.052, dependency probability = 0.017 \u2192 classified as non-essential", "gold_answer": "FAM81B", "gold_category": "depmap", "gold_extraction": {"cell_line": "HEC265_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "FAM81B", "cell_line": "HEC265_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.052165186501539}, {"gene_name": "GRK5", "cell_line": "HEC265_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0524417479953386}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["FAM81B", "GRK5"], "cell_line": "HEC265_ENDOMETRIUM"}}
+{"question_id": "GEL2-0004", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NP5_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HROB: gene effect = -0.356, dependency probability = 0.187 \u2192 classified as non-essential\n- FGF23: gene effect = -0.020, dependency probability = 0.018 \u2192 classified as non-essential\n- USF3: gene effect = 0.218, dependency probability = 0.006 \u2192 classified as non-essential", "gold_answer": "HROB", "gold_category": "depmap", "gold_extraction": {"cell_line": "NP5_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "HROB", "cell_line": "NP5_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3562302538339849}, {"gene_name": "FGF23", "cell_line": "NP5_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.020010631652541}, {"gene_name": "USF3", "cell_line": "NP5_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.21812365869281}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["HROB", "FGF23", "USF3"], "cell_line": "NP5_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0005", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PATU8988T_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SPRR3: gene effect = 0.159, dependency probability = 0.006 \u2192 classified as non-essential", "gold_answer": "SPRR3", "gold_category": "depmap", "gold_extraction": {"cell_line": "PATU8988T_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "SPRR3", "cell_line": "PATU8988T_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.158969189983951}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SPRR3"], "cell_line": "PATU8988T_PANCREAS"}}
+{"question_id": "GEL2-0006", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UACC257_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SGTA: gene effect = -0.106, dependency probability = 0.045 \u2192 classified as non-essential", "gold_answer": "SGTA", "gold_category": "depmap", "gold_extraction": {"cell_line": "UACC257_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "SGTA", "cell_line": "UACC257_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1055992713955313}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SGTA"], "cell_line": "UACC257_SKIN"}}
+{"question_id": "GEL2-0007", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in P4E6_PROSTATE (Prostate) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CTXN2: gene effect = 0.080, dependency probability = 0.007 \u2192 classified as non-essential\n- ANAPC1: gene effect = -0.457, dependency probability = 0.393 \u2192 classified as non-essential", "gold_answer": "CTXN2", "gold_category": "depmap", "gold_extraction": {"cell_line": "P4E6_PROSTATE", "screen_type": "CRISPR", "genes": [{"gene_name": "CTXN2", "cell_line": "P4E6_PROSTATE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0799288012199468}, {"gene_name": "ANAPC1", "cell_line": "P4E6_PROSTATE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4574245979410527}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CTXN2", "ANAPC1"], "cell_line": "P4E6_PROSTATE"}}
+{"question_id": "GEL2-0008", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in AM38_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CD79B: gene effect = -0.015, dependency probability = 0.025 \u2192 classified as non-essential\n- CDA: gene effect = 0.152, dependency probability = 0.008 \u2192 classified as non-essential", "gold_answer": "CD79B", "gold_category": "depmap", "gold_extraction": {"cell_line": "AM38_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "CD79B", "cell_line": "AM38_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.015197535917385}, {"gene_name": "CDA", "cell_line": "AM38_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1517537622505573}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CD79B", "CDA"], "cell_line": "AM38_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0009", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in FU97_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MED20: gene effect = -0.709, dependency probability = 0.847 \u2192 classified as non-essential\n- HSP90AB1: gene effect = -0.197, dependency probability = 0.139 \u2192 classified as non-essential\n- ATOSA: gene effect = -0.044, dependency probability = 0.025 \u2192 classified as non-essential", "gold_answer": "MED20", "gold_category": "depmap", "gold_extraction": {"cell_line": "FU97_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "MED20", "cell_line": "FU97_STOMACH", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.708634611519686}, {"gene_name": "HSP90AB1", "cell_line": "FU97_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1973711853104812}, {"gene_name": "ATOSA", "cell_line": "FU97_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0439607580354064}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["MED20", "HSP90AB1", "ATOSA"], "cell_line": "FU97_STOMACH"}}
+{"question_id": "GEL2-0010", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HEY_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TRIM5: gene effect = 0.107, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "TRIM5", "gold_category": "depmap", "gold_extraction": {"cell_line": "HEY_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "TRIM5", "cell_line": "HEY_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1074684936202648}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["TRIM5"], "cell_line": "HEY_OVARY"}}
+{"question_id": "GEL2-0011", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HEY_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- IRF2BP1: gene effect = -0.178, dependency probability = 0.173 \u2192 classified as non-essential", "gold_answer": "IRF2BP1", "gold_category": "depmap", "gold_extraction": {"cell_line": "HEY_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "IRF2BP1", "cell_line": "HEY_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1779298607823732}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["IRF2BP1"], "cell_line": "HEY_OVARY"}}
+{"question_id": "GEL2-0012", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JAR_PLACENTA (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GSDMD: gene effect = -0.184, dependency probability = 0.101 \u2192 classified as non-essential\n- BCL9L: gene effect = 0.010, dependency probability = 0.016 \u2192 classified as non-essential", "gold_answer": "GSDMD", "gold_category": "depmap", "gold_extraction": {"cell_line": "JAR_PLACENTA", "screen_type": "CRISPR", "genes": [{"gene_name": "GSDMD", "cell_line": "JAR_PLACENTA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1843072910959635}, {"gene_name": "BCL9L", "cell_line": "JAR_PLACENTA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0095656081025952}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["GSDMD", "BCL9L"], "cell_line": "JAR_PLACENTA"}}
+{"question_id": "GEL2-0013", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in LCLC103H_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DOK6: gene effect = 0.079, dependency probability = 0.011 \u2192 classified as non-essential\n- ACTN1: gene effect = -0.044, dependency probability = 0.025 \u2192 classified as non-essential", "gold_answer": "DOK6", "gold_category": "depmap", "gold_extraction": {"cell_line": "LCLC103H_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "DOK6", "cell_line": "LCLC103H_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0794292519992044}, {"gene_name": "ACTN1", "cell_line": "LCLC103H_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0440797330148476}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["DOK6", "ACTN1"], "cell_line": "LCLC103H_LUNG"}}
+{"question_id": "GEL2-0014", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SKM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GPATCH11: gene effect = 0.245, dependency probability = 0.004 \u2192 classified as non-essential\n- MIGA2: gene effect = -0.064, dependency probability = 0.032 \u2192 classified as non-essential\n- ZNF773: gene effect = 0.099, dependency probability = 0.007 \u2192 classified as non-essential", "gold_answer": "GPATCH11", "gold_category": "depmap", "gold_extraction": {"cell_line": "SKM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "GPATCH11", "cell_line": "SKM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2450292728093084}, {"gene_name": "MIGA2", "cell_line": "SKM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0635407957095836}, {"gene_name": "ZNF773", "cell_line": "SKM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0988341391879183}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["GPATCH11", "MIGA2", "ZNF773"], "cell_line": "SKM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0015", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in BXPC3_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RNASE7: gene effect = -0.098, dependency probability = 0.045 \u2192 classified as non-essential", "gold_answer": "RNASE7", "gold_category": "depmap", "gold_extraction": {"cell_line": "BXPC3_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "RNASE7", "cell_line": "BXPC3_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0975874833070327}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["RNASE7"], "cell_line": "BXPC3_PANCREAS"}}
+{"question_id": "GEL2-0016", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH2170_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DDA1: gene effect = -0.396, dependency probability = 0.386 \u2192 classified as non-essential", "gold_answer": "DDA1", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH2170_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "DDA1", "cell_line": "NCIH2170_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3960468995560532}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DDA1"], "cell_line": "NCIH2170_LUNG"}}
+{"question_id": "GEL2-0017", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MKN28_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRMT3: gene effect = -0.051, dependency probability = 0.034 \u2192 classified as non-essential\n- ATF4: gene effect = -0.198, dependency probability = 0.117 \u2192 classified as non-essential", "gold_answer": "PRMT3", "gold_category": "depmap", "gold_extraction": {"cell_line": "MKN28_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "PRMT3", "cell_line": "MKN28_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0506054633039292}, {"gene_name": "ATF4", "cell_line": "MKN28_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1979895232944571}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PRMT3", "ATF4"], "cell_line": "MKN28_STOMACH"}}
+{"question_id": "GEL2-0018", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCT15_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RNF144B: gene effect = 0.067, dependency probability = 0.013 \u2192 classified as non-essential\n- PURB: gene effect = -0.259, dependency probability = 0.115 \u2192 classified as non-essential", "gold_answer": "RNF144B", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCT15_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "RNF144B", "cell_line": "HCT15_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0672225495515554}, {"gene_name": "PURB", "cell_line": "HCT15_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2590044446391344}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["RNF144B", "PURB"], "cell_line": "HCT15_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0019", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TCCPAN2_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- UBTFL1: gene effect = -0.012, dependency probability = 0.021 \u2192 classified as non-essential\n- ARB2A: gene effect = 0.128, dependency probability = 0.002 \u2192 classified as non-essential\n- ZNF140: gene effect = 0.185, dependency probability = 0.005 \u2192 classified as non-essential", "gold_answer": "UBTFL1", "gold_category": "depmap", "gold_extraction": {"cell_line": "TCCPAN2_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "UBTFL1", "cell_line": "TCCPAN2_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0120803796112979}, {"gene_name": "ARB2A", "cell_line": "TCCPAN2_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.127673313976233}, {"gene_name": "ZNF140", "cell_line": "TCCPAN2_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1853926230056656}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["UBTFL1", "ARB2A", "ZNF140"], "cell_line": "TCCPAN2_PANCREAS"}}
+{"question_id": "GEL2-0020", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SKNFI_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PPP1R12A: gene effect = -0.606, dependency probability = 0.632 \u2192 classified as non-essential", "gold_answer": "PPP1R12A", "gold_category": "depmap", "gold_extraction": {"cell_line": "SKNFI_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "PPP1R12A", "cell_line": "SKNFI_AUTONOMIC_GANGLIA", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.6055571702118923}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PPP1R12A"], "cell_line": "SKNFI_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0021", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HAUS6: gene effect = -0.084, dependency probability = 0.032 \u2192 classified as non-essential", "gold_answer": "HAUS6", "gold_category": "depmap", "gold_extraction": {"cell_line": "MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "HAUS6", "cell_line": "MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.084174952356322}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["HAUS6"], "cell_line": "MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0022", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SHSY5Y_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CEP76: gene effect = 0.225, dependency probability = 0.001 \u2192 classified as non-essential\n- BEAN1: gene effect = -0.246, dependency probability = 0.150 \u2192 classified as non-essential", "gold_answer": "CEP76", "gold_category": "depmap", "gold_extraction": {"cell_line": "SHSY5Y_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "CEP76", "cell_line": "SHSY5Y_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2245710775338781}, {"gene_name": "BEAN1", "cell_line": "SHSY5Y_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2459688947501828}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CEP76", "BEAN1"], "cell_line": "SHSY5Y_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0023", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in WILL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KCTD8: gene effect = 0.119, dependency probability = 0.005 \u2192 classified as non-essential\n- MPST: gene effect = 0.575, dependency probability = 0.000 \u2192 classified as non-essential", "gold_answer": "KCTD8", "gold_category": "depmap", "gold_extraction": {"cell_line": "WILL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "KCTD8", "cell_line": "WILL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1194996217188004}, {"gene_name": "MPST", "cell_line": "WILL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.5750214722093524}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["KCTD8", "MPST"], "cell_line": "WILL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0024", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NO36_LUNG (Pleura) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HID1: gene effect = -0.337, dependency probability = 0.338 \u2192 classified as non-essential\n- MRPL21: gene effect = -0.402, dependency probability = 0.376 \u2192 classified as non-essential\n- FREM2: gene effect = 0.117, dependency probability = 0.010 \u2192 classified as non-essential", "gold_answer": "HID1", "gold_category": "depmap", "gold_extraction": {"cell_line": "NO36_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "HID1", "cell_line": "NO36_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3374666310561887}, {"gene_name": "MRPL21", "cell_line": "NO36_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4020002391729214}, {"gene_name": "FREM2", "cell_line": "NO36_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1168188540588078}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["HID1", "MRPL21", "FREM2"], "cell_line": "NO36_LUNG"}}
+{"question_id": "GEL2-0025", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CASKI_CERVIX (Cervix) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NDST3: gene effect = 0.106, dependency probability = 0.007 \u2192 classified as non-essential", "gold_answer": "NDST3", "gold_category": "depmap", "gold_extraction": {"cell_line": "CASKI_CERVIX", "screen_type": "CRISPR", "genes": [{"gene_name": "NDST3", "cell_line": "CASKI_CERVIX", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.105884339680511}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["NDST3"], "cell_line": "CASKI_CERVIX"}}
+{"question_id": "GEL2-0026", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in U343_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RAB1B: gene effect = -0.370, dependency probability = 0.327 \u2192 classified as non-essential", "gold_answer": "RAB1B", "gold_category": "depmap", "gold_extraction": {"cell_line": "U343_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "RAB1B", "cell_line": "U343_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3695001822311393}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["RAB1B"], "cell_line": "U343_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0027", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TFK1_BILIARY_TRACT (Biliary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MPZL2: gene effect = -0.015, dependency probability = 0.021 \u2192 classified as non-essential\n- C12orf75: gene effect = 0.026, dependency probability = 0.015 \u2192 classified as non-essential", "gold_answer": "MPZL2", "gold_category": "depmap", "gold_extraction": {"cell_line": "TFK1_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "MPZL2", "cell_line": "TFK1_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0153977944345003}, {"gene_name": "C12orf75", "cell_line": "TFK1_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0256823626841432}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["MPZL2", "C12orf75"], "cell_line": "TFK1_BILIARY_TRACT"}}
+{"question_id": "GEL2-0028", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in DAOY_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NCLN: gene effect = -0.037, dependency probability = 0.037 \u2192 classified as non-essential\n- PCDHGB1: gene effect = -0.287, dependency probability = 0.219 \u2192 classified as non-essential", "gold_answer": "NCLN", "gold_category": "depmap", "gold_extraction": {"cell_line": "DAOY_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "NCLN", "cell_line": "DAOY_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0365369046464307}, {"gene_name": "PCDHGB1", "cell_line": "DAOY_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2867067446185911}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["NCLN", "PCDHGB1"], "cell_line": "DAOY_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0029", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH211_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZCRB1: gene effect = -0.611, dependency probability = 0.818 \u2192 classified as non-essential\n- BCL6B: gene effect = 0.034, dependency probability = 0.021 \u2192 classified as non-essential\n- OR8B8: gene effect = 0.158, dependency probability = 0.009 \u2192 classified as non-essential", "gold_answer": "ZCRB1", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH211_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "ZCRB1", "cell_line": "NCIH211_LUNG", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.6105216150247216}, {"gene_name": "BCL6B", "cell_line": "NCIH211_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.034476472399365}, {"gene_name": "OR8B8", "cell_line": "NCIH211_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1581894201064546}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["ZCRB1", "BCL6B", "OR8B8"], "cell_line": "NCIH211_LUNG"}}
+{"question_id": "GEL2-0030", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in GIMEN_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KRTAP8-1: gene effect = -0.446, dependency probability = 0.229 \u2192 classified as non-essential", "gold_answer": "KRTAP8-1", "gold_category": "depmap", "gold_extraction": {"cell_line": "GIMEN_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "KRTAP8-1", "cell_line": "GIMEN_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4459697844123244}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["KRTAP8-1"], "cell_line": "GIMEN_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0031", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH526_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- AK9: gene effect = 0.013, dependency probability = 0.024 \u2192 classified as non-essential", "gold_answer": "AK9", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH526_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "AK9", "cell_line": "NCIH526_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0125866731360241}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["AK9"], "cell_line": "NCIH526_LUNG"}}
+{"question_id": "GEL2-0032", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in EGI1_BILIARY_TRACT (Biliary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CYSLTR1: gene effect = 0.079, dependency probability = 0.010 \u2192 classified as non-essential\n- WIZ: gene effect = -0.127, dependency probability = 0.060 \u2192 classified as non-essential", "gold_answer": "CYSLTR1", "gold_category": "depmap", "gold_extraction": {"cell_line": "EGI1_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "CYSLTR1", "cell_line": "EGI1_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0789344070912997}, {"gene_name": "WIZ", "cell_line": "EGI1_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1272813785026629}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CYSLTR1", "WIZ"], "cell_line": "EGI1_BILIARY_TRACT"}}
+{"question_id": "GEL2-0033", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in ZR751_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZFPM1: gene effect = -0.106, dependency probability = 0.058 \u2192 classified as non-essential\n- ZNF385A: gene effect = -0.091, dependency probability = 0.049 \u2192 classified as non-essential", "gold_answer": "ZFPM1", "gold_category": "depmap", "gold_extraction": {"cell_line": "ZR751_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "ZFPM1", "cell_line": "ZR751_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1055411704968495}, {"gene_name": "ZNF385A", "cell_line": "ZR751_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0908185954988111}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ZFPM1", "ZNF385A"], "cell_line": "ZR751_BREAST"}}
+{"question_id": "GEL2-0034", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HS578T_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ATP1B4: gene effect = -0.148, dependency probability = 0.082 \u2192 classified as non-essential\n- RLIM: gene effect = -0.150, dependency probability = 0.053 \u2192 classified as non-essential\n- ZNF134: gene effect = 0.162, dependency probability = 0.007 \u2192 classified as non-essential", "gold_answer": "ATP1B4", "gold_category": "depmap", "gold_extraction": {"cell_line": "HS578T_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "ATP1B4", "cell_line": "HS578T_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1475067806860664}, {"gene_name": "RLIM", "cell_line": "HS578T_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1498317760586763}, {"gene_name": "ZNF134", "cell_line": "HS578T_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1624464305024706}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["ATP1B4", "RLIM", "ZNF134"], "cell_line": "HS578T_BREAST"}}
+{"question_id": "GEL2-0035", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MSTO211H_PLEURA (Pleura) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- UNCX: gene effect = 0.099, dependency probability = 0.008 \u2192 classified as non-essential", "gold_answer": "UNCX", "gold_category": "depmap", "gold_extraction": {"cell_line": "MSTO211H_PLEURA", "screen_type": "CRISPR", "genes": [{"gene_name": "UNCX", "cell_line": "MSTO211H_PLEURA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0991960249649276}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["UNCX"], "cell_line": "MSTO211H_PLEURA"}}
+{"question_id": "GEL2-0036", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in U2904_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF740: gene effect = -0.011, dependency probability = 0.021 \u2192 classified as non-essential", "gold_answer": "ZNF740", "gold_category": "depmap", "gold_extraction": {"cell_line": "U2904_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF740", "cell_line": "U2904_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0108209259775493}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ZNF740"], "cell_line": "U2904_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0037", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in A673_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- APOB: gene effect = 0.303, dependency probability = 0.002 \u2192 classified as non-essential\n- TRIM14: gene effect = -0.065, dependency probability = 0.037 \u2192 classified as non-essential", "gold_answer": "APOB", "gold_category": "depmap", "gold_extraction": {"cell_line": "A673_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "APOB", "cell_line": "A673_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.3025152535342446}, {"gene_name": "TRIM14", "cell_line": "A673_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.065157827231042}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["APOB", "TRIM14"], "cell_line": "A673_BONE"}}
+{"question_id": "GEL2-0038", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MCF7_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TMEM241: gene effect = 0.265, dependency probability = 0.003 \u2192 classified as non-essential\n- SLC4A2: gene effect = 0.162, dependency probability = 0.003 \u2192 classified as non-essential", "gold_answer": "TMEM241", "gold_category": "depmap", "gold_extraction": {"cell_line": "MCF7_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "TMEM241", "cell_line": "MCF7_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2645943691055266}, {"gene_name": "SLC4A2", "cell_line": "MCF7_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1620013400714535}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["TMEM241", "SLC4A2"], "cell_line": "MCF7_BREAST"}}
+{"question_id": "GEL2-0039", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CORL47_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TMEM170A: gene effect = -0.009, dependency probability = 0.026 \u2192 classified as non-essential\n- CDC25C: gene effect = -0.261, dependency probability = 0.177 \u2192 classified as non-essential\n- ADAM17: gene effect = 0.023, dependency probability = 0.016 \u2192 classified as non-essential", "gold_answer": "TMEM170A", "gold_category": "depmap", "gold_extraction": {"cell_line": "CORL47_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "TMEM170A", "cell_line": "CORL47_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0086101097364557}, {"gene_name": "CDC25C", "cell_line": "CORL47_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2607016184863465}, {"gene_name": "ADAM17", "cell_line": "CORL47_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0228943205766546}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["TMEM170A", "CDC25C", "ADAM17"], "cell_line": "CORL47_LUNG"}}
+{"question_id": "GEL2-0040", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JVE207_COLON (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CPS1: gene effect = -0.160, dependency probability = 0.061 \u2192 classified as non-essential", "gold_answer": "CPS1", "gold_category": "depmap", "gold_extraction": {"cell_line": "JVE207_COLON", "screen_type": "CRISPR", "genes": [{"gene_name": "CPS1", "cell_line": "JVE207_COLON", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1595865840388611}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CPS1"], "cell_line": "JVE207_COLON"}}
+{"question_id": "GEL2-0041", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UW228_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF217: gene effect = -0.403, dependency probability = 0.396 \u2192 classified as non-essential", "gold_answer": "ZNF217", "gold_category": "depmap", "gold_extraction": {"cell_line": "UW228_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF217", "cell_line": "UW228_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4033632260537837}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ZNF217"], "cell_line": "UW228_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0042", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in ESS1_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRDM16: gene effect = -0.280, dependency probability = 0.307 \u2192 classified as non-essential\n- KLRD1: gene effect = 0.048, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "PRDM16", "gold_category": "depmap", "gold_extraction": {"cell_line": "ESS1_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "PRDM16", "cell_line": "ESS1_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.280186678328069}, {"gene_name": "KLRD1", "cell_line": "ESS1_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0481917110453611}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PRDM16", "KLRD1"], "cell_line": "ESS1_ENDOMETRIUM"}}
+{"question_id": "GEL2-0043", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH1355_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZSCAN5B: gene effect = 0.534, dependency probability = 0.000 \u2192 classified as non-essential\n- TUBB2A: gene effect = -0.051, dependency probability = 0.045 \u2192 classified as non-essential", "gold_answer": "ZSCAN5B", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH1355_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "ZSCAN5B", "cell_line": "NCIH1355_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.5337783729990795}, {"gene_name": "TUBB2A", "cell_line": "NCIH1355_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0507153084367813}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ZSCAN5B", "TUBB2A"], "cell_line": "NCIH1355_LUNG"}}
+{"question_id": "GEL2-0044", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KCIMOH1_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SHLD2: gene effect = -0.330, dependency probability = 0.211 \u2192 classified as non-essential\n- PYDC5: gene effect = -0.145, dependency probability = 0.117 \u2192 classified as non-essential\n- PMEPA1: gene effect = -0.108, dependency probability = 0.056 \u2192 classified as non-essential", "gold_answer": "SHLD2", "gold_category": "depmap", "gold_extraction": {"cell_line": "KCIMOH1_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "SHLD2", "cell_line": "KCIMOH1_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3301815562334468}, {"gene_name": "PYDC5", "cell_line": "KCIMOH1_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1447099407370567}, {"gene_name": "PMEPA1", "cell_line": "KCIMOH1_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1079592090446551}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["SHLD2", "PYDC5", "PMEPA1"], "cell_line": "KCIMOH1_PANCREAS"}}
+{"question_id": "GEL2-0045", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TUHR14TKB_KIDNEY (Kidney) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CTNNA3: gene effect = 0.036, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "CTNNA3", "gold_category": "depmap", "gold_extraction": {"cell_line": "TUHR14TKB_KIDNEY", "screen_type": "CRISPR", "genes": [{"gene_name": "CTNNA3", "cell_line": "TUHR14TKB_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0361749734449887}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CTNNA3"], "cell_line": "TUHR14TKB_KIDNEY"}}
+{"question_id": "GEL2-0046", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CHP212_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ARID1A: gene effect = -0.086, dependency probability = 0.040 \u2192 classified as non-essential", "gold_answer": "ARID1A", "gold_category": "depmap", "gold_extraction": {"cell_line": "CHP212_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "ARID1A", "cell_line": "CHP212_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0858360434044081}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ARID1A"], "cell_line": "CHP212_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0047", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ARL13A: gene effect = 0.137, dependency probability = 0.007 \u2192 classified as non-essential\n- CDH8: gene effect = 0.220, dependency probability = 0.004 \u2192 classified as non-essential", "gold_answer": "ARL13A", "gold_category": "depmap", "gold_extraction": {"cell_line": "KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "ARL13A", "cell_line": "KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1371284198032334}, {"gene_name": "CDH8", "cell_line": "KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2201442336605936}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ARL13A", "CDH8"], "cell_line": "KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0048", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MLX: gene effect = -0.308, dependency probability = 0.253 \u2192 classified as non-essential\n- PLEKHM3: gene effect = 0.053, dependency probability = 0.019 \u2192 classified as non-essential", "gold_answer": "MLX", "gold_category": "depmap", "gold_extraction": {"cell_line": "NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "MLX", "cell_line": "NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3080997485713839}, {"gene_name": "PLEKHM3", "cell_line": "NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0532778422152582}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["MLX", "PLEKHM3"], "cell_line": "NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0049", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in BC2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PCDHB10: gene effect = -0.065, dependency probability = 0.035 \u2192 classified as non-essential\n- CHMP7: gene effect = -0.489, dependency probability = 0.442 \u2192 classified as non-essential\n- YRDC: gene effect = -0.717, dependency probability = 0.836 \u2192 classified as non-essential", "gold_answer": "PCDHB10", "gold_category": "depmap", "gold_extraction": {"cell_line": "BC2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "PCDHB10", "cell_line": "BC2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0653635457261976}, {"gene_name": "CHMP7", "cell_line": "BC2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4885352647526446}, {"gene_name": "YRDC", "cell_line": "BC2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.7165966465304761}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["PCDHB10", "CHMP7", "YRDC"], "cell_line": "BC2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0050", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCT15_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GPR78: gene effect = 0.042, dependency probability = 0.017 \u2192 classified as non-essential", "gold_answer": "GPR78", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCT15_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "GPR78", "cell_line": "HCT15_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0419231096562534}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["GPR78"], "cell_line": "HCT15_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0051", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in ETCC016_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GLTP: gene effect = -0.041, dependency probability = 0.039 \u2192 classified as non-essential", "gold_answer": "GLTP", "gold_category": "depmap", "gold_extraction": {"cell_line": "ETCC016_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "GLTP", "cell_line": "ETCC016_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0405329108397153}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["GLTP"], "cell_line": "ETCC016_LUNG"}}
+{"question_id": "GEL2-0052", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RPE1SS51_ENGINEERED (Eye) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HOGA1: gene effect = -0.292, dependency probability = 0.157 \u2192 classified as non-essential\n- S100A1: gene effect = 0.035, dependency probability = 0.011 \u2192 classified as non-essential", "gold_answer": "HOGA1", "gold_category": "depmap", "gold_extraction": {"cell_line": "RPE1SS51_ENGINEERED", "screen_type": "CRISPR", "genes": [{"gene_name": "HOGA1", "cell_line": "RPE1SS51_ENGINEERED", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.291991126712206}, {"gene_name": "S100A1", "cell_line": "RPE1SS51_ENGINEERED", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0351680141952686}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["HOGA1", "S100A1"], "cell_line": "RPE1SS51_ENGINEERED"}}
+{"question_id": "GEL2-0053", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UMRC7_KIDNEY (Kidney) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PLEKHG1: gene effect = 0.159, dependency probability = 0.013 \u2192 classified as non-essential\n- TRPM1: gene effect = 0.356, dependency probability = 0.001 \u2192 classified as non-essential", "gold_answer": "PLEKHG1", "gold_category": "depmap", "gold_extraction": {"cell_line": "UMRC7_KIDNEY", "screen_type": "CRISPR", "genes": [{"gene_name": "PLEKHG1", "cell_line": "UMRC7_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1588236520018033}, {"gene_name": "TRPM1", "cell_line": "UMRC7_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.3558842217409223}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PLEKHG1", "TRPM1"], "cell_line": "UMRC7_KIDNEY"}}
+{"question_id": "GEL2-0054", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in FADU_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FERD3L: gene effect = -0.031, dependency probability = 0.019 \u2192 classified as non-essential\n- STEEP1: gene effect = -0.246, dependency probability = 0.116 \u2192 classified as non-essential\n- FUS: gene effect = -0.165, dependency probability = 0.099 \u2192 classified as non-essential", "gold_answer": "FERD3L", "gold_category": "depmap", "gold_extraction": {"cell_line": "FADU_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "FERD3L", "cell_line": "FADU_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0307048449238529}, {"gene_name": "STEEP1", "cell_line": "FADU_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2461985059427407}, {"gene_name": "FUS", "cell_line": "FADU_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1651885572919662}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["FERD3L", "STEEP1", "FUS"], "cell_line": "FADU_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0055", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SHMAC4_PROSTATE (Prostate) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ARMCX5: gene effect = 0.009, dependency probability = 0.019 \u2192 classified as non-essential", "gold_answer": "ARMCX5", "gold_category": "depmap", "gold_extraction": {"cell_line": "SHMAC4_PROSTATE", "screen_type": "CRISPR", "genes": [{"gene_name": "ARMCX5", "cell_line": "SHMAC4_PROSTATE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0094732383861976}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ARMCX5"], "cell_line": "SHMAC4_PROSTATE"}}
+{"question_id": "GEL2-0056", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in GB1_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PLAC1: gene effect = 0.078, dependency probability = 0.007 \u2192 classified as non-essential", "gold_answer": "PLAC1", "gold_category": "depmap", "gold_extraction": {"cell_line": "GB1_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "PLAC1", "cell_line": "GB1_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0775305432423769}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PLAC1"], "cell_line": "GB1_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0057", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC366_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- BST2: gene effect = 0.086, dependency probability = 0.015 \u2192 classified as non-essential\n- COL4A6: gene effect = -0.094, dependency probability = 0.047 \u2192 classified as non-essential", "gold_answer": "BST2", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC366_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "BST2", "cell_line": "HCC366_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.085702244375873}, {"gene_name": "COL4A6", "cell_line": "HCC366_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0937257903796504}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["BST2", "COL4A6"], "cell_line": "HCC366_LUNG"}}
+{"question_id": "GEL2-0058", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH1299_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- UBAP1: gene effect = -0.336, dependency probability = 0.347 \u2192 classified as non-essential\n- FBXO43: gene effect = -0.299, dependency probability = 0.260 \u2192 classified as non-essential", "gold_answer": "UBAP1", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH1299_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "UBAP1", "cell_line": "NCIH1299_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3360294193811304}, {"gene_name": "FBXO43", "cell_line": "NCIH1299_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2990570192443584}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["UBAP1", "FBXO43"], "cell_line": "NCIH1299_LUNG"}}
+{"question_id": "GEL2-0059", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in D425_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CAB39L: gene effect = 0.094, dependency probability = 0.009 \u2192 classified as non-essential\n- CD53: gene effect = -0.220, dependency probability = 0.140 \u2192 classified as non-essential\n- AGBL5: gene effect = -0.203, dependency probability = 0.094 \u2192 classified as non-essential", "gold_answer": "CAB39L", "gold_category": "depmap", "gold_extraction": {"cell_line": "D425_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "CAB39L", "cell_line": "D425_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0936516244303341}, {"gene_name": "CD53", "cell_line": "D425_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2197462303598343}, {"gene_name": "AGBL5", "cell_line": "D425_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2033662505120428}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["CAB39L", "CD53", "AGBL5"], "cell_line": "D425_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0060", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC515_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- IRF9: gene effect = 0.160, dependency probability = 0.005 \u2192 classified as non-essential", "gold_answer": "IRF9", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC515_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "IRF9", "cell_line": "HCC515_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1599104010755878}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["IRF9"], "cell_line": "HCC515_LUNG"}}
+{"question_id": "GEL2-0061", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HKBMM_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SULF1: gene effect = -0.030, dependency probability = 0.034 \u2192 classified as non-essential", "gold_answer": "SULF1", "gold_category": "depmap", "gold_extraction": {"cell_line": "HKBMM_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "SULF1", "cell_line": "HKBMM_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0297849072321098}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SULF1"], "cell_line": "HKBMM_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0062", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KPNSI9S_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRPF4: gene effect = -0.379, dependency probability = 0.251 \u2192 classified as non-essential\n- CBX4: gene effect = -0.035, dependency probability = 0.030 \u2192 classified as non-essential", "gold_answer": "PRPF4", "gold_category": "depmap", "gold_extraction": {"cell_line": "KPNSI9S_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "PRPF4", "cell_line": "KPNSI9S_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3793560932558444}, {"gene_name": "CBX4", "cell_line": "KPNSI9S_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0352944637984501}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PRPF4", "CBX4"], "cell_line": "KPNSI9S_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0063", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in WM3211_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RFPL1: gene effect = 0.121, dependency probability = 0.009 \u2192 classified as non-essential\n- SUGP2: gene effect = -0.196, dependency probability = 0.169 \u2192 classified as non-essential", "gold_answer": "RFPL1", "gold_category": "depmap", "gold_extraction": {"cell_line": "WM3211_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "RFPL1", "cell_line": "WM3211_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1209025599075087}, {"gene_name": "SUGP2", "cell_line": "WM3211_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.195708361387054}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["RFPL1", "SUGP2"], "cell_line": "WM3211_SKIN"}}
+{"question_id": "GEL2-0064", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH2087_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FST: gene effect = -0.001, dependency probability = 0.020 \u2192 classified as non-essential\n- ANTXRL: gene effect = -0.150, dependency probability = 0.082 \u2192 classified as non-essential\n- MAP3K7CL: gene effect = 0.002, dependency probability = 0.022 \u2192 classified as non-essential", "gold_answer": "FST", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH2087_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "FST", "cell_line": "NCIH2087_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0005451212204392}, {"gene_name": "ANTXRL", "cell_line": "NCIH2087_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1497152245218883}, {"gene_name": "MAP3K7CL", "cell_line": "NCIH2087_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0023258849152056}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["FST", "ANTXRL", "MAP3K7CL"], "cell_line": "NCIH2087_LUNG"}}
+{"question_id": "GEL2-0065", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KELLY_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ADAP1: gene effect = -0.112, dependency probability = 0.057 \u2192 classified as non-essential", "gold_answer": "ADAP1", "gold_category": "depmap", "gold_extraction": {"cell_line": "KELLY_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "ADAP1", "cell_line": "KELLY_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1117807114886458}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ADAP1"], "cell_line": "KELLY_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0066", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MCF7_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRSS55: gene effect = -0.042, dependency probability = 0.024 \u2192 classified as non-essential", "gold_answer": "PRSS55", "gold_category": "depmap", "gold_extraction": {"cell_line": "MCF7_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "PRSS55", "cell_line": "MCF7_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0418569900622262}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PRSS55"], "cell_line": "MCF7_BREAST"}}
+{"question_id": "GEL2-0067", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TT2609C02_THYROID (Thyroid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- IKBKG: gene effect = 0.031, dependency probability = 0.013 \u2192 classified as non-essential\n- FAM200A: gene effect = -0.035, dependency probability = 0.025 \u2192 classified as non-essential", "gold_answer": "IKBKG", "gold_category": "depmap", "gold_extraction": {"cell_line": "TT2609C02_THYROID", "screen_type": "CRISPR", "genes": [{"gene_name": "IKBKG", "cell_line": "TT2609C02_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0308882219969501}, {"gene_name": "FAM200A", "cell_line": "TT2609C02_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.03456276313093}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["IKBKG", "FAM200A"], "cell_line": "TT2609C02_THYROID"}}
+{"question_id": "GEL2-0068", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH2882_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HSDL1: gene effect = -0.155, dependency probability = 0.060 \u2192 classified as non-essential\n- NCR3LG1: gene effect = -0.050, dependency probability = 0.059 \u2192 classified as non-essential", "gold_answer": "HSDL1", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH2882_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "HSDL1", "cell_line": "NCIH2882_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1553405024995906}, {"gene_name": "NCR3LG1", "cell_line": "NCIH2882_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0503162840530084}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["HSDL1", "NCR3LG1"], "cell_line": "NCIH2882_LUNG"}}
+{"question_id": "GEL2-0069", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JEG3_PLACENTA (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ELF3: gene effect = 0.187, dependency probability = 0.003 \u2192 classified as non-essential\n- ALAS2: gene effect = 0.121, dependency probability = 0.010 \u2192 classified as non-essential\n- CKM: gene effect = -0.049, dependency probability = 0.039 \u2192 classified as non-essential", "gold_answer": "ELF3", "gold_category": "depmap", "gold_extraction": {"cell_line": "JEG3_PLACENTA", "screen_type": "CRISPR", "genes": [{"gene_name": "ELF3", "cell_line": "JEG3_PLACENTA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.18693254393124}, {"gene_name": "ALAS2", "cell_line": "JEG3_PLACENTA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1212119058528625}, {"gene_name": "CKM", "cell_line": "JEG3_PLACENTA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0488420066565194}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["ELF3", "ALAS2", "CKM"], "cell_line": "JEG3_PLACENTA"}}
+{"question_id": "GEL2-0070", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in LPS853_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GREM2: gene effect = -0.105, dependency probability = 0.083 \u2192 classified as non-essential", "gold_answer": "GREM2", "gold_category": "depmap", "gold_extraction": {"cell_line": "LPS853_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "GREM2", "cell_line": "LPS853_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1052941892004225}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["GREM2"], "cell_line": "LPS853_SOFT_TISSUE"}}
+{"question_id": "GEL2-0071", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PECAPJ49_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PDZRN3: gene effect = -0.050, dependency probability = 0.043 \u2192 classified as non-essential", "gold_answer": "PDZRN3", "gold_category": "depmap", "gold_extraction": {"cell_line": "PECAPJ49_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "PDZRN3", "cell_line": "PECAPJ49_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0495802972884495}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PDZRN3"], "cell_line": "PECAPJ49_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0072", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MERO25_PLEURA (Pleura) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SIGLEC8: gene effect = -0.050, dependency probability = 0.035 \u2192 classified as non-essential\n- KPNA7: gene effect = -0.375, dependency probability = 0.346 \u2192 classified as non-essential", "gold_answer": "SIGLEC8", "gold_category": "depmap", "gold_extraction": {"cell_line": "MERO25_PLEURA", "screen_type": "CRISPR", "genes": [{"gene_name": "SIGLEC8", "cell_line": "MERO25_PLEURA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0501415148039482}, {"gene_name": "KPNA7", "cell_line": "MERO25_PLEURA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3748739060680627}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["SIGLEC8", "KPNA7"], "cell_line": "MERO25_PLEURA"}}
+{"question_id": "GEL2-0073", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- YWHAE: gene effect = -0.378, dependency probability = 0.389 \u2192 classified as non-essential\n- PSTPIP2: gene effect = 0.064, dependency probability = 0.012 \u2192 classified as non-essential", "gold_answer": "YWHAE", "gold_category": "depmap", "gold_extraction": {"cell_line": "MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "YWHAE", "cell_line": "MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.378189853916656}, {"gene_name": "PSTPIP2", "cell_line": "MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0635777163533013}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["YWHAE", "PSTPIP2"], "cell_line": "MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0074", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SA3_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MTPN: gene effect = 0.032, dependency probability = 0.014 \u2192 classified as non-essential\n- ME2: gene effect = -0.127, dependency probability = 0.105 \u2192 classified as non-essential\n- SIAE: gene effect = 0.496, dependency probability = 0.000 \u2192 classified as non-essential", "gold_answer": "MTPN", "gold_category": "depmap", "gold_extraction": {"cell_line": "SA3_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "MTPN", "cell_line": "SA3_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0322945460929467}, {"gene_name": "ME2", "cell_line": "SA3_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1272668586791665}, {"gene_name": "SIAE", "cell_line": "SA3_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.4958151815752468}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["MTPN", "ME2", "SIAE"], "cell_line": "SA3_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0075", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JHOM1_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ATP2C2: gene effect = -0.206, dependency probability = 0.109 \u2192 classified as non-essential", "gold_answer": "ATP2C2", "gold_category": "depmap", "gold_extraction": {"cell_line": "JHOM1_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "ATP2C2", "cell_line": "JHOM1_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2060058779951208}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ATP2C2"], "cell_line": "JHOM1_OVARY"}}
+{"question_id": "GEL2-0076", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JVE207_COLON (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ATF7: gene effect = -0.096, dependency probability = 0.038 \u2192 classified as non-essential", "gold_answer": "ATF7", "gold_category": "depmap", "gold_extraction": {"cell_line": "JVE207_COLON", "screen_type": "CRISPR", "genes": [{"gene_name": "ATF7", "cell_line": "JVE207_COLON", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0964908496372114}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ATF7"], "cell_line": "JVE207_COLON"}}
+{"question_id": "GEL2-0077", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- UBA7: gene effect = -0.066, dependency probability = 0.043 \u2192 classified as non-essential\n- ATP6V1F: gene effect = -0.395, dependency probability = 0.469 \u2192 classified as non-essential", "gold_answer": "UBA7", "gold_category": "depmap", "gold_extraction": {"cell_line": "SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "UBA7", "cell_line": "SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0655887740804951}, {"gene_name": "ATP6V1F", "cell_line": "SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3953121565616442}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["UBA7", "ATP6V1F"], "cell_line": "SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0078", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NB6_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TPM1: gene effect = -0.141, dependency probability = 0.091 \u2192 classified as non-essential\n- PPP2R1A: gene effect = -0.178, dependency probability = 0.146 \u2192 classified as non-essential", "gold_answer": "TPM1", "gold_category": "depmap", "gold_extraction": {"cell_line": "NB6_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "TPM1", "cell_line": "NB6_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1413184069183098}, {"gene_name": "PPP2R1A", "cell_line": "NB6_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1778695869250591}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["TPM1", "PPP2R1A"], "cell_line": "NB6_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0079", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SF767_CENTRAL_NERVOUS_SYSTEM (Cervix) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KISS1R: gene effect = -0.172, dependency probability = 0.105 \u2192 classified as non-essential\n- HOXA5: gene effect = -0.264, dependency probability = 0.142 \u2192 classified as non-essential\n- GSDMA: gene effect = -0.208, dependency probability = 0.156 \u2192 classified as non-essential", "gold_answer": "KISS1R", "gold_category": "depmap", "gold_extraction": {"cell_line": "SF767_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "KISS1R", "cell_line": "SF767_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1724959380285221}, {"gene_name": "HOXA5", "cell_line": "SF767_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2638924944496055}, {"gene_name": "GSDMA", "cell_line": "SF767_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2077827888382718}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["KISS1R", "HOXA5", "GSDMA"], "cell_line": "SF767_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0080", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HUO9_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- S100P: gene effect = -0.047, dependency probability = 0.031 \u2192 classified as non-essential", "gold_answer": "S100P", "gold_category": "depmap", "gold_extraction": {"cell_line": "HUO9_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "S100P", "cell_line": "HUO9_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0471053146578338}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["S100P"], "cell_line": "HUO9_BONE"}}
+{"question_id": "GEL2-0081", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CAL33_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TMEM161A: gene effect = -0.171, dependency probability = 0.090 \u2192 classified as non-essential", "gold_answer": "TMEM161A", "gold_category": "depmap", "gold_extraction": {"cell_line": "CAL33_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "TMEM161A", "cell_line": "CAL33_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1713445970185353}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["TMEM161A"], "cell_line": "CAL33_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0082", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in LMSU_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CPD: gene effect = -0.066, dependency probability = 0.030 \u2192 classified as non-essential\n- DTNBP1: gene effect = -0.129, dependency probability = 0.071 \u2192 classified as non-essential", "gold_answer": "CPD", "gold_category": "depmap", "gold_extraction": {"cell_line": "LMSU_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "CPD", "cell_line": "LMSU_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0655376053880172}, {"gene_name": "DTNBP1", "cell_line": "LMSU_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1285545404698445}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CPD", "DTNBP1"], "cell_line": "LMSU_STOMACH"}}
+{"question_id": "GEL2-0083", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in COV362_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SULT1E1: gene effect = -0.077, dependency probability = 0.033 \u2192 classified as non-essential\n- CDKL3: gene effect = -0.117, dependency probability = 0.065 \u2192 classified as non-essential", "gold_answer": "SULT1E1", "gold_category": "depmap", "gold_extraction": {"cell_line": "COV362_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "SULT1E1", "cell_line": "COV362_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0773306318258639}, {"gene_name": "CDKL3", "cell_line": "COV362_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1170939952199064}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["SULT1E1", "CDKL3"], "cell_line": "COV362_OVARY"}}
+{"question_id": "GEL2-0084", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UMRC3_KIDNEY (Kidney) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- THNSL1: gene effect = 0.115, dependency probability = 0.006 \u2192 classified as non-essential\n- POU4F2: gene effect = 0.116, dependency probability = 0.006 \u2192 classified as non-essential\n- RYR1: gene effect = -0.028, dependency probability = 0.026 \u2192 classified as non-essential", "gold_answer": "THNSL1", "gold_category": "depmap", "gold_extraction": {"cell_line": "UMRC3_KIDNEY", "screen_type": "CRISPR", "genes": [{"gene_name": "THNSL1", "cell_line": "UMRC3_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.115286575146629}, {"gene_name": "POU4F2", "cell_line": "UMRC3_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1157505894096478}, {"gene_name": "RYR1", "cell_line": "UMRC3_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0277650744730242}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["THNSL1", "POU4F2", "RYR1"], "cell_line": "UMRC3_KIDNEY"}}
+{"question_id": "GEL2-0085", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in IGR1_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RXFP3: gene effect = 0.077 \u2192 classified as non-essential", "gold_answer": "RXFP3", "gold_category": "demeter2", "gold_extraction": {"cell_line": "IGR1_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "RXFP3", "cell_line": "IGR1_SKIN", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": 0.0768277716522}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "demeter2", "gene_symbols": ["RXFP3"], "cell_line": "IGR1_SKIN"}}
+{"question_id": "GEL2-0086", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in ST486_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HPS3: gene effect = 0.081, dependency probability = 0.007 \u2192 classified as non-essential", "gold_answer": "HPS3", "gold_category": "depmap", "gold_extraction": {"cell_line": "ST486_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "HPS3", "cell_line": "ST486_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0808733225333624}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["HPS3"], "cell_line": "ST486_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0087", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in 786O_KIDNEY (Kidney) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DCTN1: gene effect = -0.185, dependency probability = 0.127 \u2192 classified as non-essential\n- TRIB3: gene effect = 0.170, dependency probability = 0.010 \u2192 classified as non-essential", "gold_answer": "DCTN1", "gold_category": "depmap", "gold_extraction": {"cell_line": "786O_KIDNEY", "screen_type": "CRISPR", "genes": [{"gene_name": "DCTN1", "cell_line": "786O_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1849436000682854}, {"gene_name": "TRIB3", "cell_line": "786O_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1697670502374094}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["DCTN1", "TRIB3"], "cell_line": "786O_KIDNEY"}}
+{"question_id": "GEL2-0088", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in A375_SKIN_CJ1_RESISTANT (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FUT11: gene effect = -0.105, dependency probability = 0.038 \u2192 classified as non-essential\n- FAM83E: gene effect = -0.040, dependency probability = 0.033 \u2192 classified as non-essential", "gold_answer": "FUT11", "gold_category": "depmap", "gold_extraction": {"cell_line": "A375_SKIN_CJ1_RESISTANT", "screen_type": "CRISPR", "genes": [{"gene_name": "FUT11", "cell_line": "A375_SKIN_CJ1_RESISTANT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1046050898295339}, {"gene_name": "FAM83E", "cell_line": "A375_SKIN_CJ1_RESISTANT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0403432928741831}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["FUT11", "FAM83E"], "cell_line": "A375_SKIN_CJ1_RESISTANT"}}
+{"question_id": "GEL2-0089", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MSTO211H_PLEURA (Pleura) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- WDR17: gene effect = 0.018, dependency probability = 0.015 \u2192 classified as non-essential\n- JAML: gene effect = 0.117, dependency probability = 0.004 \u2192 classified as non-essential\n- PRELP: gene effect = -0.316, dependency probability = 0.217 \u2192 classified as non-essential", "gold_answer": "WDR17", "gold_category": "depmap", "gold_extraction": {"cell_line": "MSTO211H_PLEURA", "screen_type": "CRISPR", "genes": [{"gene_name": "WDR17", "cell_line": "MSTO211H_PLEURA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0181342147055361}, {"gene_name": "JAML", "cell_line": "MSTO211H_PLEURA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1165700133134558}, {"gene_name": "PRELP", "cell_line": "MSTO211H_PLEURA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3164590756587989}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["WDR17", "JAML", "PRELP"], "cell_line": "MSTO211H_PLEURA"}}
+{"question_id": "GEL2-0090", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MM253_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PTGIS: gene effect = 0.005, dependency probability = 0.018 \u2192 classified as non-essential", "gold_answer": "PTGIS", "gold_category": "depmap", "gold_extraction": {"cell_line": "MM253_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "PTGIS", "cell_line": "MM253_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0049674074621796}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PTGIS"], "cell_line": "MM253_SKIN"}}
+{"question_id": "GEL2-0091", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PECAPJ34CLONEC12_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RUNDC3A: gene effect = 0.019, dependency probability = 0.011 \u2192 classified as non-essential", "gold_answer": "RUNDC3A", "gold_category": "depmap", "gold_extraction": {"cell_line": "PECAPJ34CLONEC12_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "RUNDC3A", "cell_line": "PECAPJ34CLONEC12_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.018863674190507}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["RUNDC3A"], "cell_line": "PECAPJ34CLONEC12_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0092", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HLF_LIVER (Liver) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DTNB: gene effect = -0.029, dependency probability = 0.035 \u2192 classified as non-essential\n- NME5: gene effect = -0.261, dependency probability = 0.165 \u2192 classified as non-essential", "gold_answer": "DTNB", "gold_category": "depmap", "gold_extraction": {"cell_line": "HLF_LIVER", "screen_type": "CRISPR", "genes": [{"gene_name": "DTNB", "cell_line": "HLF_LIVER", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0288592291745416}, {"gene_name": "NME5", "cell_line": "HLF_LIVER", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2613916720601453}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["DTNB", "NME5"], "cell_line": "HLF_LIVER"}}
+{"question_id": "GEL2-0093", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU46_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PNO1: gene effect = -0.336, dependency probability = 0.179 \u2192 classified as non-essential\n- CABIN1: gene effect = -0.363, dependency probability = 0.450 \u2192 classified as non-essential", "gold_answer": "PNO1", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU46_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "PNO1", "cell_line": "SNU46_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3361777809560383}, {"gene_name": "CABIN1", "cell_line": "SNU46_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3633263129675689}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PNO1", "CABIN1"], "cell_line": "SNU46_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0094", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in U87MG_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ACSS1: gene effect = -0.056, dependency probability = 0.035 \u2192 classified as non-essential\n- NAE1: gene effect = -0.026, dependency probability = 0.034 \u2192 classified as non-essential\n- TENM1: gene effect = -0.006, dependency probability = 0.021 \u2192 classified as non-essential", "gold_answer": "ACSS1", "gold_category": "depmap", "gold_extraction": {"cell_line": "U87MG_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "ACSS1", "cell_line": "U87MG_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0564799693549372}, {"gene_name": "NAE1", "cell_line": "U87MG_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0263593978874725}, {"gene_name": "TENM1", "cell_line": "U87MG_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0064628258479718}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["ACSS1", "NAE1", "TENM1"], "cell_line": "U87MG_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0095", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in IS076A_OESOPHAGUS (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GRAMD1C: gene effect = 0.126, dependency probability = 0.004 \u2192 classified as non-essential", "gold_answer": "GRAMD1C", "gold_category": "depmap", "gold_extraction": {"cell_line": "IS076A_OESOPHAGUS", "screen_type": "CRISPR", "genes": [{"gene_name": "GRAMD1C", "cell_line": "IS076A_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1264221967350435}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["GRAMD1C"], "cell_line": "IS076A_OESOPHAGUS"}}
+{"question_id": "GEL2-0096", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in 2313287_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SSTR5: gene effect = -0.005, dependency probability = 0.011 \u2192 classified as non-essential", "gold_answer": "SSTR5", "gold_category": "depmap", "gold_extraction": {"cell_line": "2313287_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "SSTR5", "cell_line": "2313287_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0049435230837696}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SSTR5"], "cell_line": "2313287_STOMACH"}}
+{"question_id": "GEL2-0097", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in LMSU_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TRIM11: gene effect = 0.030, dependency probability = 0.011 \u2192 classified as non-essential\n- PMAIP1: gene effect = 0.286, dependency probability = 0.003 \u2192 classified as non-essential", "gold_answer": "TRIM11", "gold_category": "depmap", "gold_extraction": {"cell_line": "LMSU_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "TRIM11", "cell_line": "LMSU_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0303433995244067}, {"gene_name": "PMAIP1", "cell_line": "LMSU_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2855555347653719}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["TRIM11", "PMAIP1"], "cell_line": "LMSU_STOMACH"}}
+{"question_id": "GEL2-0098", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ESAM: gene effect = 0.320, dependency probability = 0.003 \u2192 classified as non-essential\n- ARR3: gene effect = 0.126, dependency probability = 0.010 \u2192 classified as non-essential", "gold_answer": "ESAM", "gold_category": "depmap", "gold_extraction": {"cell_line": "DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "ESAM", "cell_line": "DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.3200178811817729}, {"gene_name": "ARR3", "cell_line": "DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1263194573452123}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ESAM", "ARR3"], "cell_line": "DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0099", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HOUAI_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FXYD6: gene effect = 0.012, dependency probability = 0.012 \u2192 classified as non-essential\n- PPP1R3F: gene effect = 0.005, dependency probability = 0.021 \u2192 classified as non-essential\n- CXCL17: gene effect = -0.229, dependency probability = 0.162 \u2192 classified as non-essential", "gold_answer": "FXYD6", "gold_category": "depmap", "gold_extraction": {"cell_line": "HOUAI_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "FXYD6", "cell_line": "HOUAI_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0115274896755556}, {"gene_name": "PPP1R3F", "cell_line": "HOUAI_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0047874201125924}, {"gene_name": "CXCL17", "cell_line": "HOUAI_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2286652876785491}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["FXYD6", "PPP1R3F", "CXCL17"], "cell_line": "HOUAI_ENDOMETRIUM"}}
+{"question_id": "GEL2-0100", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CORL311_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ITGB6: gene effect = -0.033, dependency probability = 0.030 \u2192 classified as non-essential", "gold_answer": "ITGB6", "gold_category": "depmap", "gold_extraction": {"cell_line": "CORL311_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "ITGB6", "cell_line": "CORL311_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0330379769889776}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ITGB6"], "cell_line": "CORL311_LUNG"}}
+{"question_id": "GEL2-0101", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MELHO_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SOCS2: gene effect = -0.234, dependency probability = 0.107 \u2192 classified as non-essential", "gold_answer": "SOCS2", "gold_category": "depmap", "gold_extraction": {"cell_line": "MELHO_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "SOCS2", "cell_line": "MELHO_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2340979849724665}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SOCS2"], "cell_line": "MELHO_SKIN"}}
+{"question_id": "GEL2-0102", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU1079_BILIARY_TRACT (Biliary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DHH: gene effect = -0.041, dependency probability = 0.030 \u2192 classified as non-essential\n- UTP11: gene effect = -0.456, dependency probability = 0.384 \u2192 classified as non-essential", "gold_answer": "DHH", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU1079_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "DHH", "cell_line": "SNU1079_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0412881256832306}, {"gene_name": "UTP11", "cell_line": "SNU1079_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4557918366357399}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["DHH", "UTP11"], "cell_line": "SNU1079_BILIARY_TRACT"}}
+{"question_id": "GEL2-0103", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- APBB2: gene effect = 0.057, dependency probability = 0.017 \u2192 classified as non-essential\n- GDPD5: gene effect = -0.259, dependency probability = 0.129 \u2192 classified as non-essential", "gold_answer": "APBB2", "gold_category": "depmap", "gold_extraction": {"cell_line": "KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "APBB2", "cell_line": "KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0565194248827629}, {"gene_name": "GDPD5", "cell_line": "KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2593382427635697}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["APBB2", "GDPD5"], "cell_line": "KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0104", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PANC0504_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CACNG6: gene effect = 0.272, dependency probability = 0.005 \u2192 classified as non-essential\n- H3C12: gene effect = -0.040, dependency probability = 0.023 \u2192 classified as non-essential\n- ARMCX3: gene effect = 0.064, dependency probability = 0.012 \u2192 classified as non-essential", "gold_answer": "CACNG6", "gold_category": "depmap", "gold_extraction": {"cell_line": "PANC0504_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "CACNG6", "cell_line": "PANC0504_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2722145182963209}, {"gene_name": "H3C12", "cell_line": "PANC0504_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0401608223379476}, {"gene_name": "ARMCX3", "cell_line": "PANC0504_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0643175332291225}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["CACNG6", "H3C12", "ARMCX3"], "cell_line": "PANC0504_PANCREAS"}}
+{"question_id": "GEL2-0105", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in EMTOKA_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF711: gene effect = 0.063, dependency probability = 0.014 \u2192 classified as non-essential", "gold_answer": "ZNF711", "gold_category": "depmap", "gold_extraction": {"cell_line": "EMTOKA_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF711", "cell_line": "EMTOKA_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.063407021594283}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ZNF711"], "cell_line": "EMTOKA_ENDOMETRIUM"}}
+{"question_id": "GEL2-0106", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SLR20_KIDNEY (Bladder/Urinary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ETV4: gene effect = -0.045, dependency probability = 0.037 \u2192 classified as non-essential", "gold_answer": "ETV4", "gold_category": "depmap", "gold_extraction": {"cell_line": "SLR20_KIDNEY", "screen_type": "CRISPR", "genes": [{"gene_name": "ETV4", "cell_line": "SLR20_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0454673504017532}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ETV4"], "cell_line": "SLR20_KIDNEY"}}
+{"question_id": "GEL2-0107", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in FLO1_OESOPHAGUS (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CCDC87: gene effect = -0.225, dependency probability = 0.191 \u2192 classified as non-essential\n- TMEM79: gene effect = -0.049, dependency probability = 0.032 \u2192 classified as non-essential", "gold_answer": "CCDC87", "gold_category": "depmap", "gold_extraction": {"cell_line": "FLO1_OESOPHAGUS", "screen_type": "CRISPR", "genes": [{"gene_name": "CCDC87", "cell_line": "FLO1_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2250973326853651}, {"gene_name": "TMEM79", "cell_line": "FLO1_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0492987388980698}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CCDC87", "TMEM79"], "cell_line": "FLO1_OESOPHAGUS"}}
+{"question_id": "GEL2-0108", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JL1_PLEURA (Pleura) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TMCO3: gene effect = -0.008, dependency probability = 0.026 \u2192 classified as non-essential\n- CLCNKB: gene effect = -0.213, dependency probability = 0.173 \u2192 classified as non-essential", "gold_answer": "TMCO3", "gold_category": "depmap", "gold_extraction": {"cell_line": "JL1_PLEURA", "screen_type": "CRISPR", "genes": [{"gene_name": "TMCO3", "cell_line": "JL1_PLEURA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0075289017845628}, {"gene_name": "CLCNKB", "cell_line": "JL1_PLEURA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2133245567597064}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["TMCO3", "CLCNKB"], "cell_line": "JL1_PLEURA"}}
+{"question_id": "GEL2-0109", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in 8MGBA_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TMEM14A: gene effect = 0.202, dependency probability = 0.003 \u2192 classified as non-essential\n- MS4A4E: gene effect = 0.296, dependency probability = 0.004 \u2192 classified as non-essential\n- BSPRY: gene effect = 0.109, dependency probability = 0.008 \u2192 classified as non-essential", "gold_answer": "TMEM14A", "gold_category": "depmap", "gold_extraction": {"cell_line": "8MGBA_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "TMEM14A", "cell_line": "8MGBA_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2021002692307046}, {"gene_name": "MS4A4E", "cell_line": "8MGBA_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2958852450453614}, {"gene_name": "BSPRY", "cell_line": "8MGBA_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.109351200515154}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["TMEM14A", "MS4A4E", "BSPRY"], "cell_line": "8MGBA_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0110", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TEN_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CRELD2: gene effect = -0.045, dependency probability = 0.043 \u2192 classified as non-essential", "gold_answer": "CRELD2", "gold_category": "depmap", "gold_extraction": {"cell_line": "TEN_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "CRELD2", "cell_line": "TEN_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0445509840128616}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CRELD2"], "cell_line": "TEN_ENDOMETRIUM"}}
+{"question_id": "GEL2-0111", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OCIC4P_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- C4BPB: gene effect = -0.032, dependency probability = 0.041 \u2192 classified as non-essential", "gold_answer": "C4BPB", "gold_category": "depmap", "gold_extraction": {"cell_line": "OCIC4P_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "C4BPB", "cell_line": "OCIC4P_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0324339482480655}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["C4BPB"], "cell_line": "OCIC4P_OVARY"}}
+{"question_id": "GEL2-0112", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TT2609C02_THYROID (Thyroid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PIANP: gene effect = 0.043, dependency probability = 0.012 \u2192 classified as non-essential\n- UBQLN3: gene effect = 0.110, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "PIANP", "gold_category": "depmap", "gold_extraction": {"cell_line": "TT2609C02_THYROID", "screen_type": "CRISPR", "genes": [{"gene_name": "PIANP", "cell_line": "TT2609C02_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0432499127067972}, {"gene_name": "UBQLN3", "cell_line": "TT2609C02_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1095226864443591}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PIANP", "UBQLN3"], "cell_line": "TT2609C02_THYROID"}}
+{"question_id": "GEL2-0113", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RD_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CPA3: gene effect = 0.046, dependency probability = 0.010 \u2192 classified as non-essential\n- PXYLP1: gene effect = -0.052, dependency probability = 0.039 \u2192 classified as non-essential", "gold_answer": "CPA3", "gold_category": "depmap", "gold_extraction": {"cell_line": "RD_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "CPA3", "cell_line": "RD_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.045916283158425}, {"gene_name": "PXYLP1", "cell_line": "RD_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0522711269290255}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CPA3", "PXYLP1"], "cell_line": "RD_SOFT_TISSUE"}}
+{"question_id": "GEL2-0114", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HAP1_ENGINEERED (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRKCI: gene effect = 0.014, dependency probability = 0.011 \u2192 classified as non-essential\n- SCLY: gene effect = -0.121, dependency probability = 0.059 \u2192 classified as non-essential\n- SLC38A2: gene effect = -0.061, dependency probability = 0.035 \u2192 classified as non-essential", "gold_answer": "PRKCI", "gold_category": "depmap", "gold_extraction": {"cell_line": "HAP1_ENGINEERED", "screen_type": "CRISPR", "genes": [{"gene_name": "PRKCI", "cell_line": "HAP1_ENGINEERED", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0142449103388111}, {"gene_name": "SCLY", "cell_line": "HAP1_ENGINEERED", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1211663013130283}, {"gene_name": "SLC38A2", "cell_line": "HAP1_ENGINEERED", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0608922895102679}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["PRKCI", "SCLY", "SLC38A2"], "cell_line": "HAP1_ENGINEERED"}}
+{"question_id": "GEL2-0115", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU719_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SST: gene effect = -0.061, dependency probability = 0.037 \u2192 classified as non-essential", "gold_answer": "SST", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU719_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "SST", "cell_line": "SNU719_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0608206770132504}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SST"], "cell_line": "SNU719_STOMACH"}}
+{"question_id": "GEL2-0116", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NRH-GCT2 (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- EVI2B: gene effect = -0.168, dependency probability = 0.101 \u2192 classified as non-essential", "gold_answer": "EVI2B", "gold_category": "depmap", "gold_extraction": {"cell_line": "NRH-GCT2", "screen_type": "CRISPR", "genes": [{"gene_name": "EVI2B", "cell_line": "NRH-GCT2", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1676064637641905}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["EVI2B"], "cell_line": "NRH-GCT2"}}
+{"question_id": "GEL2-0117", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in COLO800_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PDE10A: gene effect = -0.026, dependency probability = 0.018 \u2192 classified as non-essential\n- IFNA16: gene effect = 0.238, dependency probability = 0.002 \u2192 classified as non-essential", "gold_answer": "PDE10A", "gold_category": "depmap", "gold_extraction": {"cell_line": "COLO800_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "PDE10A", "cell_line": "COLO800_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0258628469311437}, {"gene_name": "IFNA16", "cell_line": "COLO800_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2382216636975589}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PDE10A", "IFNA16"], "cell_line": "COLO800_SKIN"}}
+{"question_id": "GEL2-0118", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU719_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HSPA4L: gene effect = 0.208, dependency probability = 0.005 \u2192 classified as non-essential\n- SNRPN: gene effect = -0.056, dependency probability = 0.037 \u2192 classified as non-essential", "gold_answer": "HSPA4L", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU719_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "HSPA4L", "cell_line": "SNU719_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2082453566399998}, {"gene_name": "SNRPN", "cell_line": "SNU719_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0557566390599393}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["HSPA4L", "SNRPN"], "cell_line": "SNU719_STOMACH"}}
+{"question_id": "GEL2-0119", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MEC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TIRAP: gene effect = -0.030, dependency probability = 0.023 \u2192 classified as non-essential\n- TMEM252: gene effect = 0.049, dependency probability = 0.011 \u2192 classified as non-essential\n- ARIH1: gene effect = -0.238, dependency probability = 0.210 \u2192 classified as non-essential", "gold_answer": "TIRAP", "gold_category": "depmap", "gold_extraction": {"cell_line": "MEC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "TIRAP", "cell_line": "MEC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0299919341613099}, {"gene_name": "TMEM252", "cell_line": "MEC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0486176089158982}, {"gene_name": "ARIH1", "cell_line": "MEC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.237505038625962}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["TIRAP", "TMEM252", "ARIH1"], "cell_line": "MEC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0120", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SCCOHT1_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PCDHB12: gene effect = 0.130, dependency probability = 0.005 \u2192 classified as non-essential", "gold_answer": "PCDHB12", "gold_category": "depmap", "gold_extraction": {"cell_line": "SCCOHT1_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "PCDHB12", "cell_line": "SCCOHT1_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.130428648711553}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PCDHB12"], "cell_line": "SCCOHT1_OVARY"}}
+{"question_id": "GEL2-0121", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UPCISCC200_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CCR6: gene effect = -0.060, dependency probability = 0.037 \u2192 classified as non-essential", "gold_answer": "CCR6", "gold_category": "depmap", "gold_extraction": {"cell_line": "UPCISCC200_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "CCR6", "cell_line": "UPCISCC200_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.059973644802731}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CCR6"], "cell_line": "UPCISCC200_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0122", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in WPE1NA22_PROSTATE (Prostate) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FABP6: gene effect = 0.189, dependency probability = 0.010 \u2192 classified as non-essential\n- TNFSF10: gene effect = 0.048, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "FABP6", "gold_category": "depmap", "gold_extraction": {"cell_line": "WPE1NA22_PROSTATE", "screen_type": "CRISPR", "genes": [{"gene_name": "FABP6", "cell_line": "WPE1NA22_PROSTATE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.188606958240906}, {"gene_name": "TNFSF10", "cell_line": "WPE1NA22_PROSTATE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0475128551304008}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["FABP6", "TNFSF10"], "cell_line": "WPE1NA22_PROSTATE"}}
+{"question_id": "GEL2-0123", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CORL105_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CLCC1: gene effect = -0.227, dependency probability = 0.125 \u2192 classified as non-essential\n- CYP21A2: gene effect = -0.149, dependency probability = 0.053 \u2192 classified as non-essential", "gold_answer": "CLCC1", "gold_category": "depmap", "gold_extraction": {"cell_line": "CORL105_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "CLCC1", "cell_line": "CORL105_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2274959465222356}, {"gene_name": "CYP21A2", "cell_line": "CORL105_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1492363290756184}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CLCC1", "CYP21A2"], "cell_line": "CORL105_LUNG"}}
+{"question_id": "GEL2-0124", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UACC257_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- S100A13: gene effect = -0.082, dependency probability = 0.037 \u2192 classified as non-essential\n- SEC31A: gene effect = -0.049, dependency probability = 0.049 \u2192 classified as non-essential\n- MIS18BP1: gene effect = -0.711, dependency probability = 0.772 \u2192 classified as non-essential", "gold_answer": "S100A13", "gold_category": "depmap", "gold_extraction": {"cell_line": "UACC257_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "S100A13", "cell_line": "UACC257_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0819980771156194}, {"gene_name": "SEC31A", "cell_line": "UACC257_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.048578748482305}, {"gene_name": "MIS18BP1", "cell_line": "UACC257_SKIN", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.7105573820645199}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["S100A13", "SEC31A", "MIS18BP1"], "cell_line": "UACC257_SKIN"}}
+{"question_id": "GEL2-0125", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC1937_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ABCB9: gene effect = -0.015, dependency probability = 0.041 \u2192 classified as non-essential", "gold_answer": "ABCB9", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC1937_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "ABCB9", "cell_line": "HCC1937_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.014502334185425}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ABCB9"], "cell_line": "HCC1937_BREAST"}}
+{"question_id": "GEL2-0126", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HT144_SKIN_FV1_RESISTANT (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- BAIAP2L1: gene effect = -0.119, dependency probability = 0.060 \u2192 classified as non-essential", "gold_answer": "BAIAP2L1", "gold_category": "depmap", "gold_extraction": {"cell_line": "HT144_SKIN_FV1_RESISTANT", "screen_type": "CRISPR", "genes": [{"gene_name": "BAIAP2L1", "cell_line": "HT144_SKIN_FV1_RESISTANT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1187141642033483}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["BAIAP2L1"], "cell_line": "HT144_SKIN_FV1_RESISTANT"}}
+{"question_id": "GEL2-0127", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OVCA420_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PSMG1: gene effect = -0.221, dependency probability = 0.192 \u2192 classified as non-essential\n- C11orf96: gene effect = -0.052, dependency probability = 0.033 \u2192 classified as non-essential", "gold_answer": "PSMG1", "gold_category": "depmap", "gold_extraction": {"cell_line": "OVCA420_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "PSMG1", "cell_line": "OVCA420_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2208478726029288}, {"gene_name": "C11orf96", "cell_line": "OVCA420_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0516412822014411}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PSMG1", "C11orf96"], "cell_line": "OVCA420_OVARY"}}
+{"question_id": "GEL2-0128", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UMUC7_URINARY_TRACT (Bladder/Urinary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PLS1: gene effect = 0.184, dependency probability = 0.010 \u2192 classified as non-essential\n- SDS: gene effect = 0.172, dependency probability = 0.004 \u2192 classified as non-essential", "gold_answer": "PLS1", "gold_category": "depmap", "gold_extraction": {"cell_line": "UMUC7_URINARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "PLS1", "cell_line": "UMUC7_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1844387017489308}, {"gene_name": "SDS", "cell_line": "UMUC7_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1724424532512238}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PLS1", "SDS"], "cell_line": "UMUC7_URINARY_TRACT"}}
+{"question_id": "GEL2-0129", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SKNAS_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CHST6: gene effect = -0.086, dependency probability = 0.060 \u2192 classified as non-essential\n- MSANTD2: gene effect = -0.212, dependency probability = 0.124 \u2192 classified as non-essential\n- TMEM176B: gene effect = -0.008, dependency probability = 0.021 \u2192 classified as non-essential", "gold_answer": "CHST6", "gold_category": "depmap", "gold_extraction": {"cell_line": "SKNAS_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "CHST6", "cell_line": "SKNAS_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0860292024745098}, {"gene_name": "MSANTD2", "cell_line": "SKNAS_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2117646766074193}, {"gene_name": "TMEM176B", "cell_line": "SKNAS_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0082196042137222}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["CHST6", "MSANTD2", "TMEM176B"], "cell_line": "SKNAS_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0130", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CFAP45: gene effect = -0.169, dependency probability = 0.073 \u2192 classified as non-essential", "gold_answer": "CFAP45", "gold_category": "depmap", "gold_extraction": {"cell_line": "HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "CFAP45", "cell_line": "HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1694918678703215}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CFAP45"], "cell_line": "HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0131", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UMUC9_URINARY_TRACT (Bladder/Urinary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CAPN5: gene effect = -0.128, dependency probability = 0.052 \u2192 classified as non-essential", "gold_answer": "CAPN5", "gold_category": "depmap", "gold_extraction": {"cell_line": "UMUC9_URINARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "CAPN5", "cell_line": "UMUC9_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1278674838613292}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CAPN5"], "cell_line": "UMUC9_URINARY_TRACT"}}
+{"question_id": "GEL2-0132", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in INA6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF526: gene effect = -0.041, dependency probability = 0.034 \u2192 classified as non-essential\n- RNASE13: gene effect = -0.283, dependency probability = 0.167 \u2192 classified as non-essential", "gold_answer": "ZNF526", "gold_category": "depmap", "gold_extraction": {"cell_line": "INA6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF526", "cell_line": "INA6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0407979479212229}, {"gene_name": "RNASE13", "cell_line": "INA6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2833867097623133}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ZNF526", "RNASE13"], "cell_line": "INA6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0133", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ULK4: gene effect = 0.181, dependency probability = 0.002 \u2192 classified as non-essential\n- CPSF2: gene effect = -0.649, dependency probability = 0.676 \u2192 classified as non-essential", "gold_answer": "ULK4", "gold_category": "depmap", "gold_extraction": {"cell_line": "SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "ULK4", "cell_line": "SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.181447758875991}, {"gene_name": "CPSF2", "cell_line": "SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.648943124869897}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ULK4", "CPSF2"], "cell_line": "SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0134", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in A673_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RAB39A: gene effect = -0.196, dependency probability = 0.084 \u2192 classified as non-essential\n- RANBP9: gene effect = -0.339, dependency probability = 0.320 \u2192 classified as non-essential\n- RENBP: gene effect = 0.078, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "RAB39A", "gold_category": "depmap", "gold_extraction": {"cell_line": "A673_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "RAB39A", "cell_line": "A673_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1958531265760946}, {"gene_name": "RANBP9", "cell_line": "A673_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3388505785140722}, {"gene_name": "RENBP", "cell_line": "A673_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0782663531509753}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["RAB39A", "RANBP9", "RENBP"], "cell_line": "A673_BONE"}}
+{"question_id": "GEL2-0135", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CL11_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRSS21: gene effect = 0.076, dependency probability = 0.011 \u2192 classified as non-essential", "gold_answer": "PRSS21", "gold_category": "depmap", "gold_extraction": {"cell_line": "CL11_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "PRSS21", "cell_line": "CL11_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0758400009340956}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PRSS21"], "cell_line": "CL11_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0136", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SUM52PE_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MRE11: gene effect = -0.098, dependency probability = 0.052 \u2192 classified as non-essential", "gold_answer": "MRE11", "gold_category": "depmap", "gold_extraction": {"cell_line": "SUM52PE_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "MRE11", "cell_line": "SUM52PE_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0981865045683143}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MRE11"], "cell_line": "SUM52PE_BREAST"}}
+{"question_id": "GEL2-0137", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KE97_STOMACH (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRXL2A: gene effect = -0.331, dependency probability = 0.211 \u2192 classified as non-essential\n- BLZF1: gene effect = -0.176, dependency probability = 0.071 \u2192 classified as non-essential", "gold_answer": "PRXL2A", "gold_category": "depmap", "gold_extraction": {"cell_line": "KE97_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "PRXL2A", "cell_line": "KE97_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3307977785023401}, {"gene_name": "BLZF1", "cell_line": "KE97_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1759787665531361}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PRXL2A", "BLZF1"], "cell_line": "KE97_STOMACH"}}
+{"question_id": "GEL2-0138", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in WM3211_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- C12orf75: gene effect = 0.104, dependency probability = 0.011 \u2192 classified as non-essential\n- RAP1A: gene effect = -0.204, dependency probability = 0.104 \u2192 classified as non-essential", "gold_answer": "C12orf75", "gold_category": "depmap", "gold_extraction": {"cell_line": "WM3211_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "C12orf75", "cell_line": "WM3211_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1042175344852126}, {"gene_name": "RAP1A", "cell_line": "WM3211_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2042900566801653}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["C12orf75", "RAP1A"], "cell_line": "WM3211_SKIN"}}
+{"question_id": "GEL2-0139", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PSS141_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRRT1B: gene effect = -0.095, dependency probability = 0.044 \u2192 classified as non-essential\n- PCDHGA10: gene effect = -0.244, dependency probability = 0.140 \u2192 classified as non-essential\n- MTMR2: gene effect = 0.099, dependency probability = 0.007 \u2192 classified as non-essential", "gold_answer": "PRRT1B", "gold_category": "depmap", "gold_extraction": {"cell_line": "PSS141_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "PRRT1B", "cell_line": "PSS141_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0948364260168485}, {"gene_name": "PCDHGA10", "cell_line": "PSS141_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2438494929082814}, {"gene_name": "MTMR2", "cell_line": "PSS141_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0985295441058576}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["PRRT1B", "PCDHGA10", "MTMR2"], "cell_line": "PSS141_BONE"}}
+{"question_id": "GEL2-0140", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in 5637_URINARY_TRACT (Bladder/Urinary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MDM2: gene effect = -0.316, dependency probability = 0.264 \u2192 classified as non-essential", "gold_answer": "MDM2", "gold_category": "depmap", "gold_extraction": {"cell_line": "5637_URINARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "MDM2", "cell_line": "5637_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3161512565903127}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MDM2"], "cell_line": "5637_URINARY_TRACT"}}
+{"question_id": "GEL2-0141", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NOS1_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PASK: gene effect = 0.281, dependency probability = 0.002 \u2192 classified as non-essential", "gold_answer": "PASK", "gold_category": "depmap", "gold_extraction": {"cell_line": "NOS1_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "PASK", "cell_line": "NOS1_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2814729684575583}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PASK"], "cell_line": "NOS1_BONE"}}
+{"question_id": "GEL2-0142", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KCIMOH1_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF729: gene effect = 0.228, dependency probability = 0.002 \u2192 classified as non-essential\n- PSMG3: gene effect = -0.652, dependency probability = 0.728 \u2192 classified as non-essential", "gold_answer": "ZNF729", "gold_category": "depmap", "gold_extraction": {"cell_line": "KCIMOH1_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF729", "cell_line": "KCIMOH1_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2282684398018744}, {"gene_name": "PSMG3", "cell_line": "KCIMOH1_PANCREAS", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.6524872260845249}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ZNF729", "PSMG3"], "cell_line": "KCIMOH1_PANCREAS"}}
+{"question_id": "GEL2-0143", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in EW1_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ETNK1: gene effect = -0.061, dependency probability = 0.026 \u2192 classified as non-essential\n- ZMAT3: gene effect = 0.080, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "ETNK1", "gold_category": "depmap", "gold_extraction": {"cell_line": "EW1_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "ETNK1", "cell_line": "EW1_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0614472902291067}, {"gene_name": "ZMAT3", "cell_line": "EW1_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.079516665813816}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ETNK1", "ZMAT3"], "cell_line": "EW1_BONE"}}
+{"question_id": "GEL2-0144", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in COV504_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RGL4: gene effect = -0.008, dependency probability = 0.022 \u2192 classified as non-essential\n- USP6: gene effect = -0.178, dependency probability = 0.118 \u2192 classified as non-essential\n- TAB3: gene effect = 0.050, dependency probability = 0.011 \u2192 classified as non-essential", "gold_answer": "RGL4", "gold_category": "depmap", "gold_extraction": {"cell_line": "COV504_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "RGL4", "cell_line": "COV504_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0080620876951503}, {"gene_name": "USP6", "cell_line": "COV504_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1782231640538963}, {"gene_name": "TAB3", "cell_line": "COV504_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0501809797227769}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["RGL4", "USP6", "TAB3"], "cell_line": "COV504_OVARY"}}
+{"question_id": "GEL2-0145", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in 143B_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SDR9C7: gene effect = -0.099, dependency probability = 0.060 \u2192 classified as non-essential", "gold_answer": "SDR9C7", "gold_category": "depmap", "gold_extraction": {"cell_line": "143B_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "SDR9C7", "cell_line": "143B_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0988145041024005}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SDR9C7"], "cell_line": "143B_BONE"}}
+{"question_id": "GEL2-0146", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UACC62_SKIN_CJ1_RESISTANT (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- C6: gene effect = -0.031, dependency probability = 0.024 \u2192 classified as non-essential", "gold_answer": "C6", "gold_category": "depmap", "gold_extraction": {"cell_line": "UACC62_SKIN_CJ1_RESISTANT", "screen_type": "CRISPR", "genes": [{"gene_name": "C6", "cell_line": "UACC62_SKIN_CJ1_RESISTANT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0311830094888971}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["C6"], "cell_line": "UACC62_SKIN_CJ1_RESISTANT"}}
+{"question_id": "GEL2-0147", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH838_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF484: gene effect = -0.053, dependency probability = 0.049 \u2192 classified as non-essential\n- PTGR3: gene effect = 0.038, dependency probability = 0.015 \u2192 classified as non-essential", "gold_answer": "ZNF484", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH838_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF484", "cell_line": "NCIH838_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0527499344588731}, {"gene_name": "PTGR3", "cell_line": "NCIH838_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0383599464611527}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ZNF484", "PTGR3"], "cell_line": "NCIH838_LUNG"}}
+{"question_id": "GEL2-0148", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KYSE140_OESOPHAGUS (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RNF223: gene effect = -0.248, dependency probability = 0.192 \u2192 classified as non-essential\n- ANAPC7: gene effect = -0.151, dependency probability = 0.099 \u2192 classified as non-essential", "gold_answer": "RNF223", "gold_category": "depmap", "gold_extraction": {"cell_line": "KYSE140_OESOPHAGUS", "screen_type": "CRISPR", "genes": [{"gene_name": "RNF223", "cell_line": "KYSE140_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2476494245811664}, {"gene_name": "ANAPC7", "cell_line": "KYSE140_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1505721364229233}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["RNF223", "ANAPC7"], "cell_line": "KYSE140_OESOPHAGUS"}}
+{"question_id": "GEL2-0149", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NTNG2: gene effect = 0.098, dependency probability = 0.009 \u2192 classified as non-essential\n- ADH5: gene effect = -0.467, dependency probability = 0.431 \u2192 classified as non-essential\n- MGAT4C: gene effect = 0.032, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "NTNG2", "gold_category": "depmap", "gold_extraction": {"cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "NTNG2", "cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0984838509313693}, {"gene_name": "ADH5", "cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4673670050828708}, {"gene_name": "MGAT4C", "cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0322830729274083}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["NTNG2", "ADH5", "MGAT4C"], "cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0150", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU626_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DNAJA2: gene effect = 0.226, dependency probability = 0.010 \u2192 classified as non-essential", "gold_answer": "DNAJA2", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU626_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "DNAJA2", "cell_line": "SNU626_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.226245955106949}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DNAJA2"], "cell_line": "SNU626_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0151", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CAS1_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FANCF: gene effect = -0.150, dependency probability = 0.090 \u2192 classified as non-essential", "gold_answer": "FANCF", "gold_category": "depmap", "gold_extraction": {"cell_line": "CAS1_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "FANCF", "cell_line": "CAS1_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1495094299212033}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["FANCF"], "cell_line": "CAS1_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0152", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCCCCS1BC1_Sarcoma_Clear_Cell (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- C22orf15: gene effect = -0.051, dependency probability = 0.035 \u2192 classified as non-essential\n- OIT3: gene effect = -0.090, dependency probability = 0.065 \u2192 classified as non-essential", "gold_answer": "C22orf15", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCCCCS1BC1_Sarcoma_Clear_Cell", "screen_type": "CRISPR", "genes": [{"gene_name": "C22orf15", "cell_line": "NCCCCS1BC1_Sarcoma_Clear_Cell", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0509881839474195}, {"gene_name": "OIT3", "cell_line": "NCCCCS1BC1_Sarcoma_Clear_Cell", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0895055501146197}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["C22orf15", "OIT3"], "cell_line": "NCCCCS1BC1_Sarcoma_Clear_Cell"}}
+{"question_id": "GEL2-0153", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH2172_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MFAP4: gene effect = -0.104, dependency probability = 0.057 \u2192 classified as non-essential\n- TFAP2B: gene effect = 0.021, dependency probability = 0.016 \u2192 classified as non-essential", "gold_answer": "MFAP4", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH2172_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "MFAP4", "cell_line": "NCIH2172_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1044395172518512}, {"gene_name": "TFAP2B", "cell_line": "NCIH2172_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0210111868054242}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["MFAP4", "TFAP2B"], "cell_line": "NCIH2172_LUNG"}}
+{"question_id": "GEL2-0154", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OVISE_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- EI24: gene effect = 0.247, dependency probability = 0.001 \u2192 classified as non-essential\n- MPZ: gene effect = -0.160, dependency probability = 0.061 \u2192 classified as non-essential\n- NKX6-1: gene effect = 0.129, dependency probability = 0.003 \u2192 classified as non-essential", "gold_answer": "EI24", "gold_category": "depmap", "gold_extraction": {"cell_line": "OVISE_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "EI24", "cell_line": "OVISE_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2474369236989116}, {"gene_name": "MPZ", "cell_line": "OVISE_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1601675073273951}, {"gene_name": "NKX6-1", "cell_line": "OVISE_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1292646347151216}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["EI24", "MPZ", "NKX6-1"], "cell_line": "OVISE_OVARY"}}
+{"question_id": "GEL2-0155", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SEMK2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DGLUCY: gene effect = 0.105, dependency probability = 0.005 \u2192 classified as non-essential", "gold_answer": "DGLUCY", "gold_category": "depmap", "gold_extraction": {"cell_line": "SEMK2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "DGLUCY", "cell_line": "SEMK2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1053274875710649}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DGLUCY"], "cell_line": "SEMK2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0156", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TGBC52TKB_BILIARY_TRACT (Ampulla of Vater) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SUPT7L: gene effect = 0.178, dependency probability = 0.004 \u2192 classified as non-essential", "gold_answer": "SUPT7L", "gold_category": "depmap", "gold_extraction": {"cell_line": "TGBC52TKB_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "SUPT7L", "cell_line": "TGBC52TKB_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.178359240596419}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SUPT7L"], "cell_line": "TGBC52TKB_BILIARY_TRACT"}}
+{"question_id": "GEL2-0157", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HKA1_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DEFB134: gene effect = -0.142, dependency probability = 0.058 \u2192 classified as non-essential\n- CHAD: gene effect = -0.239, dependency probability = 0.134 \u2192 classified as non-essential", "gold_answer": "DEFB134", "gold_category": "depmap", "gold_extraction": {"cell_line": "HKA1_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "DEFB134", "cell_line": "HKA1_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1418719408121529}, {"gene_name": "CHAD", "cell_line": "HKA1_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2394813705663222}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["DEFB134", "CHAD"], "cell_line": "HKA1_SKIN"}}
+{"question_id": "GEL2-0158", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SUM1315MO2_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KRT84: gene effect = -0.235 \u2192 classified as non-essential\n- TEX46: gene effect = -0.237, dependency probability = 0.144 \u2192 classified as non-essential", "gold_answer": "KRT84", "gold_category": "demeter2", "gold_extraction": {"cell_line": "SUM1315MO2_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "KRT84", "cell_line": "SUM1315MO2_BREAST", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.235262642669}, {"gene_name": "TEX46", "cell_line": "SUM1315MO2_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2366972697909721}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "demeter2", "gene_symbols": ["KRT84", "TEX46"], "cell_line": "SUM1315MO2_BREAST"}}
+{"question_id": "GEL2-0159", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in LPS853_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TAS2R42: gene effect = 0.362, dependency probability = 0.000 \u2192 classified as non-essential\n- CRNN: gene effect = 0.077 \u2192 classified as non-essential\n- CPA6: gene effect = -0.306, dependency probability = 0.157 \u2192 classified as non-essential", "gold_answer": "TAS2R42", "gold_category": "depmap", "gold_extraction": {"cell_line": "LPS853_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "TAS2R42", "cell_line": "LPS853_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.3615379825837977}, {"gene_name": "CRNN", "cell_line": "LPS853_SOFT_TISSUE", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": 0.0768259681361}, {"gene_name": "CPA6", "cell_line": "LPS853_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3061994700513968}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["TAS2R42", "CRNN", "CPA6"], "cell_line": "LPS853_SOFT_TISSUE"}}
+{"question_id": "GEL2-0160", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KML1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MR1: gene effect = 0.298, dependency probability = 0.001 \u2192 classified as non-essential", "gold_answer": "MR1", "gold_category": "depmap", "gold_extraction": {"cell_line": "KML1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "MR1", "cell_line": "KML1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2976296780733313}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MR1"], "cell_line": "KML1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0161", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TN2_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RNF224: gene effect = -0.134, dependency probability = 0.089 \u2192 classified as non-essential", "gold_answer": "RNF224", "gold_category": "depmap", "gold_extraction": {"cell_line": "TN2_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "RNF224", "cell_line": "TN2_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1336317960953416}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["RNF224"], "cell_line": "TN2_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0162", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in A549_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CRIM1: gene effect = -0.160, dependency probability = 0.073 \u2192 classified as non-essential\n- PEF1: gene effect = -0.318, dependency probability = 0.369 \u2192 classified as non-essential", "gold_answer": "CRIM1", "gold_category": "depmap", "gold_extraction": {"cell_line": "A549_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "CRIM1", "cell_line": "A549_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1602774337679658}, {"gene_name": "PEF1", "cell_line": "A549_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3175860878469363}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CRIM1", "PEF1"], "cell_line": "A549_LUNG"}}
+{"question_id": "GEL2-0163", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OCUBM_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MGST1: gene effect = 0.207, dependency probability = 0.010 \u2192 classified as non-essential\n- UQCRB: gene effect = -0.298, dependency probability = 0.228 \u2192 classified as non-essential", "gold_answer": "MGST1", "gold_category": "depmap", "gold_extraction": {"cell_line": "OCUBM_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "MGST1", "cell_line": "OCUBM_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2070133577435451}, {"gene_name": "UQCRB", "cell_line": "OCUBM_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2983322312372402}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["MGST1", "UQCRB"], "cell_line": "OCUBM_BREAST"}}
+{"question_id": "GEL2-0164", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in 5637_URINARY_TRACT (Bladder/Urinary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF14: gene effect = 0.100, dependency probability = 0.005 \u2192 classified as non-essential\n- ASB12: gene effect = 0.074, dependency probability = 0.012 \u2192 classified as non-essential\n- TTI1: gene effect = -0.436, dependency probability = 0.389 \u2192 classified as non-essential", "gold_answer": "ZNF14", "gold_category": "depmap", "gold_extraction": {"cell_line": "5637_URINARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF14", "cell_line": "5637_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0998237596130055}, {"gene_name": "ASB12", "cell_line": "5637_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0735164070231668}, {"gene_name": "TTI1", "cell_line": "5637_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4356786810598648}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["ZNF14", "ASB12", "TTI1"], "cell_line": "5637_URINARY_TRACT"}}
+{"question_id": "GEL2-0165", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MPP89_PLEURA (Pleura) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GALR2: gene effect = -0.057, dependency probability = 0.033 \u2192 classified as non-essential", "gold_answer": "GALR2", "gold_category": "depmap", "gold_extraction": {"cell_line": "MPP89_PLEURA", "screen_type": "CRISPR", "genes": [{"gene_name": "GALR2", "cell_line": "MPP89_PLEURA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0571281580455422}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["GALR2"], "cell_line": "MPP89_PLEURA"}}
+{"question_id": "GEL2-0166", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PATU8988T_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- INCENP: gene effect = -0.444, dependency probability = 0.597 \u2192 classified as non-essential", "gold_answer": "INCENP", "gold_category": "depmap", "gold_extraction": {"cell_line": "PATU8988T_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "INCENP", "cell_line": "PATU8988T_PANCREAS", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.4442668691709045}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["INCENP"], "cell_line": "PATU8988T_PANCREAS"}}
+{"question_id": "GEL2-0167", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in AM38_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CYS1: gene effect = -0.135, dependency probability = 0.062 \u2192 classified as non-essential\n- HJV: gene effect = -0.356, dependency probability = 0.276 \u2192 classified as non-essential", "gold_answer": "CYS1", "gold_category": "depmap", "gold_extraction": {"cell_line": "AM38_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "CYS1", "cell_line": "AM38_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1352587760549097}, {"gene_name": "HJV", "cell_line": "AM38_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3560028712907038}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CYS1", "HJV"], "cell_line": "AM38_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0168", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in YD15_SALIVARY_GLAND (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- EFCAB12: gene effect = -0.051, dependency probability = 0.035 \u2192 classified as non-essential\n- IFFO2: gene effect = 0.046, dependency probability = 0.018 \u2192 classified as non-essential", "gold_answer": "EFCAB12", "gold_category": "depmap", "gold_extraction": {"cell_line": "YD15_SALIVARY_GLAND", "screen_type": "CRISPR", "genes": [{"gene_name": "EFCAB12", "cell_line": "YD15_SALIVARY_GLAND", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0508888651291102}, {"gene_name": "IFFO2", "cell_line": "YD15_SALIVARY_GLAND", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0464610895292362}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["EFCAB12", "IFFO2"], "cell_line": "YD15_SALIVARY_GLAND"}}
+{"question_id": "GEL2-0169", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TTC442_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DOCK11: gene effect = 0.073, dependency probability = 0.007 \u2192 classified as non-essential\n- CALR3: gene effect = -0.149, dependency probability = 0.101 \u2192 classified as non-essential\n- TNFAIP8L3: gene effect = -0.086, dependency probability = 0.040 \u2192 classified as non-essential", "gold_answer": "DOCK11", "gold_category": "depmap", "gold_extraction": {"cell_line": "TTC442_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "DOCK11", "cell_line": "TTC442_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0732129743817593}, {"gene_name": "CALR3", "cell_line": "TTC442_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.148581860413857}, {"gene_name": "TNFAIP8L3", "cell_line": "TTC442_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.085776469956225}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["DOCK11", "CALR3", "TNFAIP8L3"], "cell_line": "TTC442_SOFT_TISSUE"}}
+{"question_id": "GEL2-0170", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in DKMG_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RBM14: gene effect = -0.093, dependency probability = 0.042 \u2192 classified as non-essential", "gold_answer": "RBM14", "gold_category": "depmap", "gold_extraction": {"cell_line": "DKMG_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "RBM14", "cell_line": "DKMG_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.092518873578322}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["RBM14"], "cell_line": "DKMG_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0171", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in IS076A_OESOPHAGUS (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MIP: gene effect = -0.037, dependency probability = 0.028 \u2192 classified as non-essential", "gold_answer": "MIP", "gold_category": "depmap", "gold_extraction": {"cell_line": "IS076A_OESOPHAGUS", "screen_type": "CRISPR", "genes": [{"gene_name": "MIP", "cell_line": "IS076A_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0369398962539234}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MIP"], "cell_line": "IS076A_OESOPHAGUS"}}
+{"question_id": "GEL2-0172", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SW982_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TAP1: gene effect = 0.022, dependency probability = 0.015 \u2192 classified as non-essential\n- SPACA4: gene effect = -0.045, dependency probability = 0.030 \u2192 classified as non-essential", "gold_answer": "TAP1", "gold_category": "depmap", "gold_extraction": {"cell_line": "SW982_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "TAP1", "cell_line": "SW982_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0218207356760392}, {"gene_name": "SPACA4", "cell_line": "SW982_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0453023483962588}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["TAP1", "SPACA4"], "cell_line": "SW982_SOFT_TISSUE"}}
+{"question_id": "GEL2-0173", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MCC13_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TBC1D23: gene effect = -0.066, dependency probability = 0.031 \u2192 classified as non-essential\n- TESK2: gene effect = -0.129, dependency probability = 0.093 \u2192 classified as non-essential", "gold_answer": "TBC1D23", "gold_category": "depmap", "gold_extraction": {"cell_line": "MCC13_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "TBC1D23", "cell_line": "MCC13_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0663103400987504}, {"gene_name": "TESK2", "cell_line": "MCC13_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1294766517574141}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["TBC1D23", "TESK2"], "cell_line": "MCC13_SKIN"}}
+{"question_id": "GEL2-0174", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in 786O_KIDNEY (Kidney) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DNAJB13: gene effect = 0.044, dependency probability = 0.014 \u2192 classified as non-essential\n- CCL8: gene effect = 0.023, dependency probability = 0.025 \u2192 classified as non-essential\n- NACAD: gene effect = -0.019, dependency probability = 0.021 \u2192 classified as non-essential", "gold_answer": "DNAJB13", "gold_category": "depmap", "gold_extraction": {"cell_line": "786O_KIDNEY", "screen_type": "CRISPR", "genes": [{"gene_name": "DNAJB13", "cell_line": "786O_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0443650769698205}, {"gene_name": "CCL8", "cell_line": "786O_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0229520754887285}, {"gene_name": "NACAD", "cell_line": "786O_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0190502684572539}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["DNAJB13", "CCL8", "NACAD"], "cell_line": "786O_KIDNEY"}}
+{"question_id": "GEL2-0175", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC33_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- BSND: gene effect = -0.051, dependency probability = 0.026 \u2192 classified as non-essential", "gold_answer": "BSND", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC33_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "BSND", "cell_line": "HCC33_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.051342657797475}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["BSND"], "cell_line": "HCC33_LUNG"}}
+{"question_id": "GEL2-0176", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in BC3_PLEURA (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PEX14: gene effect = -0.443, dependency probability = 0.424 \u2192 classified as non-essential", "gold_answer": "PEX14", "gold_category": "depmap", "gold_extraction": {"cell_line": "BC3_PLEURA", "screen_type": "CRISPR", "genes": [{"gene_name": "PEX14", "cell_line": "BC3_PLEURA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4431231605108836}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PEX14"], "cell_line": "BC3_PLEURA"}}
+{"question_id": "GEL2-0177", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in BC2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- EDRF1: gene effect = -0.161, dependency probability = 0.079 \u2192 classified as non-essential\n- TNFSF10: gene effect = 0.126, dependency probability = 0.009 \u2192 classified as non-essential", "gold_answer": "EDRF1", "gold_category": "depmap", "gold_extraction": {"cell_line": "BC2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "EDRF1", "cell_line": "BC2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1610207398341381}, {"gene_name": "TNFSF10", "cell_line": "BC2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1257069874458427}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["EDRF1", "TNFSF10"], "cell_line": "BC2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0178", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NGP_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SH3BP2: gene effect = 0.011, dependency probability = 0.016 \u2192 classified as non-essential\n- GJB7: gene effect = 0.273, dependency probability = 0.002 \u2192 classified as non-essential", "gold_answer": "SH3BP2", "gold_category": "depmap", "gold_extraction": {"cell_line": "NGP_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "SH3BP2", "cell_line": "NGP_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0114906471193125}, {"gene_name": "GJB7", "cell_line": "NGP_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2728791614902485}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["SH3BP2", "GJB7"], "cell_line": "NGP_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0179", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU1033_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- LAGE3: gene effect = 0.366, dependency probability = 0.001 \u2192 classified as non-essential\n- LRRC1: gene effect = 0.021, dependency probability = 0.018 \u2192 classified as non-essential\n- OR4B1: gene effect = -0.171, dependency probability = 0.122 \u2192 classified as non-essential", "gold_answer": "LAGE3", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU1033_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "LAGE3", "cell_line": "SNU1033_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.3662850416193488}, {"gene_name": "LRRC1", "cell_line": "SNU1033_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0208422498759614}, {"gene_name": "OR4B1", "cell_line": "SNU1033_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1706046178113843}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["LAGE3", "LRRC1", "OR4B1"], "cell_line": "SNU1033_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0180", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MM160113_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PIPOX: gene effect = -0.131, dependency probability = 0.060 \u2192 classified as non-essential", "gold_answer": "PIPOX", "gold_category": "depmap", "gold_extraction": {"cell_line": "MM160113_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "PIPOX", "cell_line": "MM160113_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.131077845592383}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PIPOX"], "cell_line": "MM160113_SKIN"}}
+{"question_id": "GEL2-0181", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SW579_THYROID (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- IFI27L1: gene effect = -0.107, dependency probability = 0.060 \u2192 classified as non-essential", "gold_answer": "IFI27L1", "gold_category": "depmap", "gold_extraction": {"cell_line": "SW579_THYROID", "screen_type": "CRISPR", "genes": [{"gene_name": "IFI27L1", "cell_line": "SW579_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1071783428964241}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["IFI27L1"], "cell_line": "SW579_THYROID"}}
+{"question_id": "GEL2-0182", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TTC549_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DMRT2: gene effect = 0.552, dependency probability = 0.000 \u2192 classified as non-essential\n- WASHC2A: gene effect = -0.020, dependency probability = 0.023 \u2192 classified as non-essential", "gold_answer": "DMRT2", "gold_category": "depmap", "gold_extraction": {"cell_line": "TTC549_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "DMRT2", "cell_line": "TTC549_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.552493856724781}, {"gene_name": "WASHC2A", "cell_line": "TTC549_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0198610602872337}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["DMRT2", "WASHC2A"], "cell_line": "TTC549_SOFT_TISSUE"}}
+{"question_id": "GEL2-0183", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in EVSAT_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- LSM3: gene effect = 0.089, dependency probability = 0.011 \u2192 classified as non-essential\n- C21orf58: gene effect = -0.160, dependency probability = 0.090 \u2192 classified as non-essential", "gold_answer": "LSM3", "gold_category": "depmap", "gold_extraction": {"cell_line": "EVSAT_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "LSM3", "cell_line": "EVSAT_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0889389108403222}, {"gene_name": "C21orf58", "cell_line": "EVSAT_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.159535849526043}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["LSM3", "C21orf58"], "cell_line": "EVSAT_BREAST"}}
+{"question_id": "GEL2-0184", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in EPLC272H_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KLKB1: gene effect = 0.061, dependency probability = 0.017 \u2192 classified as non-essential\n- MPST: gene effect = -0.171, dependency probability = 0.069 \u2192 classified as non-essential\n- FOXO4: gene effect = 0.004, dependency probability = 0.015 \u2192 classified as non-essential", "gold_answer": "KLKB1", "gold_category": "depmap", "gold_extraction": {"cell_line": "EPLC272H_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "KLKB1", "cell_line": "EPLC272H_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0610805904511004}, {"gene_name": "MPST", "cell_line": "EPLC272H_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1705389432094674}, {"gene_name": "FOXO4", "cell_line": "EPLC272H_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0037175664399887}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["KLKB1", "MPST", "FOXO4"], "cell_line": "EPLC272H_LUNG"}}
+{"question_id": "GEL2-0185", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in LN428_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CERS3: gene effect = 0.171, dependency probability = 0.003 \u2192 classified as non-essential", "gold_answer": "CERS3", "gold_category": "depmap", "gold_extraction": {"cell_line": "LN428_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "CERS3", "cell_line": "LN428_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1705342822616889}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CERS3"], "cell_line": "LN428_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0186", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UPCISCC111_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SCN11A: gene effect = -0.089, dependency probability = 0.058 \u2192 classified as non-essential", "gold_answer": "SCN11A", "gold_category": "depmap", "gold_extraction": {"cell_line": "UPCISCC111_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "SCN11A", "cell_line": "UPCISCC111_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0892496417483027}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SCN11A"], "cell_line": "UPCISCC111_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0187", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KU1919_URINARY_TRACT (Bladder/Urinary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SKA2: gene effect = -0.440, dependency probability = 0.498 \u2192 classified as non-essential\n- C5orf34: gene effect = -0.169, dependency probability = 0.065 \u2192 classified as non-essential", "gold_answer": "SKA2", "gold_category": "depmap", "gold_extraction": {"cell_line": "KU1919_URINARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "SKA2", "cell_line": "KU1919_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4398775415928017}, {"gene_name": "C5orf34", "cell_line": "KU1919_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1686461662618077}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["SKA2", "C5orf34"], "cell_line": "KU1919_URINARY_TRACT"}}
+{"question_id": "GEL2-0188", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC1419_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- VASN: gene effect = 0.101, dependency probability = 0.010 \u2192 classified as non-essential\n- SAXO2: gene effect = 0.005, dependency probability = 0.024 \u2192 classified as non-essential", "gold_answer": "VASN", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC1419_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "VASN", "cell_line": "HCC1419_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1005922177187151}, {"gene_name": "SAXO2", "cell_line": "HCC1419_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.004899802311849}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["VASN", "SAXO2"], "cell_line": "HCC1419_BREAST"}}
+{"question_id": "GEL2-0189", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH226_LUNG (Pleura) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DSG3: gene effect = -0.138, dependency probability = 0.072 \u2192 classified as non-essential\n- SLCO6A1: gene effect = 0.227, dependency probability = 0.001 \u2192 classified as non-essential\n- MYH10: gene effect = -0.136, dependency probability = 0.071 \u2192 classified as non-essential", "gold_answer": "DSG3", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH226_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "DSG3", "cell_line": "NCIH226_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1379935740189397}, {"gene_name": "SLCO6A1", "cell_line": "NCIH226_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2274704780913165}, {"gene_name": "MYH10", "cell_line": "NCIH226_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1360369522705257}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["DSG3", "SLCO6A1", "MYH10"], "cell_line": "NCIH226_LUNG"}}
+{"question_id": "GEL2-0190", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH1437_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TOX: gene effect = 0.010, dependency probability = 0.016 \u2192 classified as non-essential", "gold_answer": "TOX", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH1437_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "TOX", "cell_line": "NCIH1437_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0095096368926439}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["TOX"], "cell_line": "NCIH1437_LUNG"}}
+{"question_id": "GEL2-0191", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KYSE30_OESOPHAGUS (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FRRS1L: gene effect = -0.183, dependency probability = 0.102 \u2192 classified as non-essential", "gold_answer": "FRRS1L", "gold_category": "depmap", "gold_extraction": {"cell_line": "KYSE30_OESOPHAGUS", "screen_type": "CRISPR", "genes": [{"gene_name": "FRRS1L", "cell_line": "KYSE30_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1828033110674196}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["FRRS1L"], "cell_line": "KYSE30_OESOPHAGUS"}}
+{"question_id": "GEL2-0192", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF234: gene effect = 0.125, dependency probability = 0.003 \u2192 classified as non-essential\n- COX6B2: gene effect = 0.069, dependency probability = 0.016 \u2192 classified as non-essential", "gold_answer": "ZNF234", "gold_category": "depmap", "gold_extraction": {"cell_line": "RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF234", "cell_line": "RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1250674309839768}, {"gene_name": "COX6B2", "cell_line": "RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0690272343916891}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ZNF234", "COX6B2"], "cell_line": "RCHACV_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0193", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in D423MG_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- LEFTY2: gene effect = -0.124, dependency probability = 0.066 \u2192 classified as non-essential\n- SNX30: gene effect = 0.192, dependency probability = 0.001 \u2192 classified as non-essential", "gold_answer": "LEFTY2", "gold_category": "depmap", "gold_extraction": {"cell_line": "D423MG_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "LEFTY2", "cell_line": "D423MG_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1237894829619725}, {"gene_name": "SNX30", "cell_line": "D423MG_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1922073716054137}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["LEFTY2", "SNX30"], "cell_line": "D423MG_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0194", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HSQ89_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- B4GALNT4: gene effect = -0.040, dependency probability = 0.022 \u2192 classified as non-essential\n- OR56B4: gene effect = -0.050, dependency probability = 0.028 \u2192 classified as non-essential\n- DUSP5: gene effect = -0.154, dependency probability = 0.059 \u2192 classified as non-essential", "gold_answer": "B4GALNT4", "gold_category": "depmap", "gold_extraction": {"cell_line": "HSQ89_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "B4GALNT4", "cell_line": "HSQ89_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0396185561891355}, {"gene_name": "OR56B4", "cell_line": "HSQ89_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.050464041890623}, {"gene_name": "DUSP5", "cell_line": "HSQ89_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.153690561829369}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["B4GALNT4", "OR56B4", "DUSP5"], "cell_line": "HSQ89_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0195", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OVMANA_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RET: gene effect = -0.271, dependency probability = 0.163 \u2192 classified as non-essential", "gold_answer": "RET", "gold_category": "depmap", "gold_extraction": {"cell_line": "OVMANA_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "RET", "cell_line": "OVMANA_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2708744567265626}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["RET"], "cell_line": "OVMANA_OVARY"}}
+{"question_id": "GEL2-0196", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU638_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NUDT5: gene effect = 0.207, dependency probability = 0.002 \u2192 classified as non-essential", "gold_answer": "NUDT5", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU638_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "NUDT5", "cell_line": "SNU638_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2072067007222519}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["NUDT5"], "cell_line": "SNU638_STOMACH"}}
+{"question_id": "GEL2-0197", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in J82_URINARY_TRACT (Bladder/Urinary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- BCORL1: gene effect = 0.456, dependency probability = 0.001 \u2192 classified as non-essential\n- RNF138: gene effect = -0.014, dependency probability = 0.023 \u2192 classified as non-essential", "gold_answer": "BCORL1", "gold_category": "depmap", "gold_extraction": {"cell_line": "J82_URINARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "BCORL1", "cell_line": "J82_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.455696415719839}, {"gene_name": "RNF138", "cell_line": "J82_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.014407806985964}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["BCORL1", "RNF138"], "cell_line": "J82_URINARY_TRACT"}}
+{"question_id": "GEL2-0198", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in U2904_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NDUFA1: gene effect = -0.024, dependency probability = 0.024 \u2192 classified as non-essential\n- TSEN2: gene effect = -0.314, dependency probability = 0.248 \u2192 classified as non-essential", "gold_answer": "NDUFA1", "gold_category": "depmap", "gold_extraction": {"cell_line": "U2904_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "NDUFA1", "cell_line": "U2904_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0244527999681404}, {"gene_name": "TSEN2", "cell_line": "U2904_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3143191808205138}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["NDUFA1", "TSEN2"], "cell_line": "U2904_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0199", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RPE1SS48_ENGINEERED (Eye) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CHKA: gene effect = -0.376, dependency probability = 0.325 \u2192 classified as non-essential\n- NAGA: gene effect = -0.059, dependency probability = 0.027 \u2192 classified as non-essential\n- UBXN10: gene effect = -0.129, dependency probability = 0.085 \u2192 classified as non-essential", "gold_answer": "CHKA", "gold_category": "depmap", "gold_extraction": {"cell_line": "RPE1SS48_ENGINEERED", "screen_type": "CRISPR", "genes": [{"gene_name": "CHKA", "cell_line": "RPE1SS48_ENGINEERED", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3762709418114984}, {"gene_name": "NAGA", "cell_line": "RPE1SS48_ENGINEERED", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0589389940208635}, {"gene_name": "UBXN10", "cell_line": "RPE1SS48_ENGINEERED", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1289166038607668}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["CHKA", "NAGA", "UBXN10"], "cell_line": "RPE1SS48_ENGINEERED"}}
+{"question_id": "GEL2-0200", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in IMR32_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- UBE2J1: gene effect = -0.027, dependency probability = 0.039 \u2192 classified as non-essential", "gold_answer": "UBE2J1", "gold_category": "depmap", "gold_extraction": {"cell_line": "IMR32_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "UBE2J1", "cell_line": "IMR32_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0269459751939553}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["UBE2J1"], "cell_line": "IMR32_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0201", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC78_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF219: gene effect = -0.046, dependency probability = 0.047 \u2192 classified as non-essential", "gold_answer": "ZNF219", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC78_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF219", "cell_line": "HCC78_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0463681413257837}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ZNF219"], "cell_line": "HCC78_LUNG"}}
+{"question_id": "GEL2-0202", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH2171_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRODH: gene effect = -0.195, dependency probability = 0.166 \u2192 classified as non-essential\n- GPR87: gene effect = -0.072, dependency probability = 0.063 \u2192 classified as non-essential", "gold_answer": "PRODH", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH2171_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "PRODH", "cell_line": "NCIH2171_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1950316330314139}, {"gene_name": "GPR87", "cell_line": "NCIH2171_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0721600708499079}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PRODH", "GPR87"], "cell_line": "NCIH2171_LUNG"}}
+{"question_id": "GEL2-0203", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UMUC5_URINARY_TRACT (Bladder/Urinary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- IDUA: gene effect = -0.064, dependency probability = 0.026 \u2192 classified as non-essential\n- TRIM10: gene effect = -0.023, dependency probability = 0.021 \u2192 classified as non-essential", "gold_answer": "IDUA", "gold_category": "depmap", "gold_extraction": {"cell_line": "UMUC5_URINARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "IDUA", "cell_line": "UMUC5_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0644989340060177}, {"gene_name": "TRIM10", "cell_line": "UMUC5_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0229319512333797}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["IDUA", "TRIM10"], "cell_line": "UMUC5_URINARY_TRACT"}}
+{"question_id": "GEL2-0204", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in WM983B_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NPHP1: gene effect = -0.050, dependency probability = 0.030 \u2192 classified as non-essential\n- RGP1: gene effect = -0.138, dependency probability = 0.057 \u2192 classified as non-essential\n- ANXA9: gene effect = -0.313, dependency probability = 0.187 \u2192 classified as non-essential", "gold_answer": "NPHP1", "gold_category": "depmap", "gold_extraction": {"cell_line": "WM983B_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "NPHP1", "cell_line": "WM983B_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0500202620862541}, {"gene_name": "RGP1", "cell_line": "WM983B_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.138266684943175}, {"gene_name": "ANXA9", "cell_line": "WM983B_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3133709525347382}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["NPHP1", "RGP1", "ANXA9"], "cell_line": "WM983B_SKIN"}}
+{"question_id": "GEL2-0205", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PITX3: gene effect = 0.055, dependency probability = 0.011 \u2192 classified as non-essential", "gold_answer": "PITX3", "gold_category": "depmap", "gold_extraction": {"cell_line": "MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "PITX3", "cell_line": "MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0552533990303818}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PITX3"], "cell_line": "MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0206", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CH157MN_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PLEKHG4: gene effect = 0.030, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "PLEKHG4", "gold_category": "depmap", "gold_extraction": {"cell_line": "CH157MN_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "PLEKHG4", "cell_line": "CH157MN_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0300498991820608}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PLEKHG4"], "cell_line": "CH157MN_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0207", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SA3_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CSRP1: gene effect = -0.087, dependency probability = 0.050 \u2192 classified as non-essential\n- AHCYL2: gene effect = 0.010, dependency probability = 0.015 \u2192 classified as non-essential", "gold_answer": "CSRP1", "gold_category": "depmap", "gold_extraction": {"cell_line": "SA3_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "CSRP1", "cell_line": "SA3_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0869608938297433}, {"gene_name": "AHCYL2", "cell_line": "SA3_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0102650776871975}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CSRP1", "AHCYL2"], "cell_line": "SA3_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0208", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SCCH196_SOFT_TISSUE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TUFM: gene effect = -0.258, dependency probability = 0.189 \u2192 classified as non-essential\n- LBR: gene effect = 0.044, dependency probability = 0.010 \u2192 classified as non-essential", "gold_answer": "TUFM", "gold_category": "depmap", "gold_extraction": {"cell_line": "SCCH196_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "TUFM", "cell_line": "SCCH196_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2582410246499109}, {"gene_name": "LBR", "cell_line": "SCCH196_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.043821690740203}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["TUFM", "LBR"], "cell_line": "SCCH196_SOFT_TISSUE"}}
+{"question_id": "GEL2-0209", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in IHH4_THYROID (Thyroid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CLDN1: gene effect = -0.165, dependency probability = 0.100 \u2192 classified as non-essential\n- ZNF438: gene effect = 0.076, dependency probability = 0.012 \u2192 classified as non-essential\n- ENTPD1: gene effect = 0.090, dependency probability = 0.008 \u2192 classified as non-essential", "gold_answer": "CLDN1", "gold_category": "depmap", "gold_extraction": {"cell_line": "IHH4_THYROID", "screen_type": "CRISPR", "genes": [{"gene_name": "CLDN1", "cell_line": "IHH4_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1650192505540038}, {"gene_name": "ZNF438", "cell_line": "IHH4_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0756820483082058}, {"gene_name": "ENTPD1", "cell_line": "IHH4_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0902526465139597}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["CLDN1", "ZNF438", "ENTPD1"], "cell_line": "IHH4_THYROID"}}
+{"question_id": "GEL2-0210", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in 253JBV_URINARY_TRACT (Bladder/Urinary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- IQCF5: gene effect = 0.083, dependency probability = 0.006 \u2192 classified as non-essential", "gold_answer": "IQCF5", "gold_category": "depmap", "gold_extraction": {"cell_line": "253JBV_URINARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "IQCF5", "cell_line": "253JBV_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0830178111082495}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["IQCF5"], "cell_line": "253JBV_URINARY_TRACT"}}
+{"question_id": "GEL2-0211", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HSC5_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RB1CC1: gene effect = -0.101, dependency probability = 0.059 \u2192 classified as non-essential", "gold_answer": "RB1CC1", "gold_category": "depmap", "gold_extraction": {"cell_line": "HSC5_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "RB1CC1", "cell_line": "HSC5_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1012218802612522}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["RB1CC1"], "cell_line": "HSC5_SKIN"}}
+{"question_id": "GEL2-0212", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HS683_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- LPCAT4: gene effect = -0.091, dependency probability = 0.057 \u2192 classified as non-essential\n- ST8SIA6: gene effect = -0.079, dependency probability = 0.047 \u2192 classified as non-essential", "gold_answer": "LPCAT4", "gold_category": "depmap", "gold_extraction": {"cell_line": "HS683_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "LPCAT4", "cell_line": "HS683_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0907463678878862}, {"gene_name": "ST8SIA6", "cell_line": "HS683_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0786473651999253}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["LPCAT4", "ST8SIA6"], "cell_line": "HS683_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0213", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KPNSI9S_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ITGB7: gene effect = -0.413, dependency probability = 0.299 \u2192 classified as non-essential\n- FOXL2NB: gene effect = -0.120, dependency probability = 0.060 \u2192 classified as non-essential", "gold_answer": "ITGB7", "gold_category": "depmap", "gold_extraction": {"cell_line": "KPNSI9S_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "ITGB7", "cell_line": "KPNSI9S_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4127585073916052}, {"gene_name": "FOXL2NB", "cell_line": "KPNSI9S_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1202979286167514}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ITGB7", "FOXL2NB"], "cell_line": "KPNSI9S_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0214", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in AMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ALG13: gene effect = -0.165, dependency probability = 0.093 \u2192 classified as non-essential\n- SCN3A: gene effect = 0.060, dependency probability = 0.016 \u2192 classified as non-essential\n- SENP1: gene effect = -0.035, dependency probability = 0.026 \u2192 classified as non-essential", "gold_answer": "ALG13", "gold_category": "depmap", "gold_extraction": {"cell_line": "AMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "ALG13", "cell_line": "AMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1645039106389637}, {"gene_name": "SCN3A", "cell_line": "AMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0596875712937094}, {"gene_name": "SENP1", "cell_line": "AMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0350253797640126}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["ALG13", "SCN3A", "SENP1"], "cell_line": "AMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0215", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in T98G_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NCAPD3: gene effect = -0.292, dependency probability = 0.323 \u2192 classified as non-essential", "gold_answer": "NCAPD3", "gold_category": "depmap", "gold_extraction": {"cell_line": "T98G_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "NCAPD3", "cell_line": "T98G_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2921450860993191}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["NCAPD3"], "cell_line": "T98G_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0216", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU1105_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- OR2T4: gene effect = -0.151 \u2192 classified as non-essential", "gold_answer": "OR2T4", "gold_category": "demeter2", "gold_extraction": {"cell_line": "SNU1105_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "OR2T4", "cell_line": "SNU1105_CENTRAL_NERVOUS_SYSTEM", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.15060769449}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "demeter2", "gene_symbols": ["OR2T4"], "cell_line": "SNU1105_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0217", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KIJK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CMBL: gene effect = 0.192, dependency probability = 0.005 \u2192 classified as non-essential\n- MOCOS: gene effect = -0.066, dependency probability = 0.030 \u2192 classified as non-essential", "gold_answer": "CMBL", "gold_category": "depmap", "gold_extraction": {"cell_line": "KIJK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "CMBL", "cell_line": "KIJK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1916575750395843}, {"gene_name": "MOCOS", "cell_line": "KIJK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0658511766395983}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CMBL", "MOCOS"], "cell_line": "KIJK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0218", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CTV1DM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KLRC1: gene effect = 0.028, dependency probability = 0.022 \u2192 classified as non-essential\n- LIN28A: gene effect = -0.142 \u2192 classified as non-essential", "gold_answer": "KLRC1", "gold_category": "depmap", "gold_extraction": {"cell_line": "CTV1DM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "KLRC1", "cell_line": "CTV1DM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0276242964337942}, {"gene_name": "LIN28A", "cell_line": "CTV1DM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.142362612633}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["KLRC1", "LIN28A"], "cell_line": "CTV1DM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0219", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SIHA_CERVIX (Cervix) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SLC4A9: gene effect = -0.183, dependency probability = 0.093 \u2192 classified as non-essential\n- VAMP1: gene effect = 0.063, dependency probability = 0.018 \u2192 classified as non-essential\n- SNX29: gene effect = 0.040, dependency probability = 0.019 \u2192 classified as non-essential", "gold_answer": "SLC4A9", "gold_category": "depmap", "gold_extraction": {"cell_line": "SIHA_CERVIX", "screen_type": "CRISPR", "genes": [{"gene_name": "SLC4A9", "cell_line": "SIHA_CERVIX", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1832659904444933}, {"gene_name": "VAMP1", "cell_line": "SIHA_CERVIX", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0631387939358836}, {"gene_name": "SNX29", "cell_line": "SIHA_CERVIX", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0401637314768143}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["SLC4A9", "VAMP1", "SNX29"], "cell_line": "SIHA_CERVIX"}}
+{"question_id": "GEL2-0220", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in BCPAP_THYROID (Thyroid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NUP37: gene effect = -0.542, dependency probability = 0.769 \u2192 classified as non-essential", "gold_answer": "NUP37", "gold_category": "depmap", "gold_extraction": {"cell_line": "BCPAP_THYROID", "screen_type": "CRISPR", "genes": [{"gene_name": "NUP37", "cell_line": "BCPAP_THYROID", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.5418161427631485}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["NUP37"], "cell_line": "BCPAP_THYROID"}}
+{"question_id": "GEL2-0221", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in U2OS_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- OR2Y1: gene effect = 0.092, dependency probability = 0.006 \u2192 classified as non-essential", "gold_answer": "OR2Y1", "gold_category": "depmap", "gold_extraction": {"cell_line": "U2OS_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "OR2Y1", "cell_line": "U2OS_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0918536171649548}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["OR2Y1"], "cell_line": "U2OS_BONE"}}
+{"question_id": "GEL2-0222", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in ASH3_THYROID (Thyroid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF154: gene effect = 0.046, dependency probability = 0.012 \u2192 classified as non-essential\n- BARHL2: gene effect = -0.190, dependency probability = 0.106 \u2192 classified as non-essential", "gold_answer": "ZNF154", "gold_category": "depmap", "gold_extraction": {"cell_line": "ASH3_THYROID", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF154", "cell_line": "ASH3_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0461703382926486}, {"gene_name": "BARHL2", "cell_line": "ASH3_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1898601275582746}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ZNF154", "BARHL2"], "cell_line": "ASH3_THYROID"}}
+{"question_id": "GEL2-0223", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC78_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PBK: gene effect = 0.108, dependency probability = 0.016 \u2192 classified as non-essential\n- OR1A2: gene effect = 0.208 \u2192 classified as non-essential", "gold_answer": "PBK", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC78_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "PBK", "cell_line": "HCC78_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1084962112578425}, {"gene_name": "OR1A2", "cell_line": "HCC78_LUNG", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": 0.208370458879}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PBK", "OR1A2"], "cell_line": "HCC78_LUNG"}}
+{"question_id": "GEL2-0224", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MCF7_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MINAR2: gene effect = 0.024, dependency probability = 0.015 \u2192 classified as non-essential\n- PITPNM3: gene effect = -0.028, dependency probability = 0.029 \u2192 classified as non-essential\n- LAMP3: gene effect = -0.161, dependency probability = 0.104 \u2192 classified as non-essential", "gold_answer": "MINAR2", "gold_category": "depmap", "gold_extraction": {"cell_line": "MCF7_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "MINAR2", "cell_line": "MCF7_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.023982481273317}, {"gene_name": "PITPNM3", "cell_line": "MCF7_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.028122684884473}, {"gene_name": "LAMP3", "cell_line": "MCF7_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1606617342832741}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["MINAR2", "PITPNM3", "LAMP3"], "cell_line": "MCF7_BREAST"}}
+{"question_id": "GEL2-0225", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in DL221_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KLK5: gene effect = -0.189, dependency probability = 0.095 \u2192 classified as non-essential", "gold_answer": "KLK5", "gold_category": "depmap", "gold_extraction": {"cell_line": "DL221_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "KLK5", "cell_line": "DL221_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.188789130435991}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["KLK5"], "cell_line": "DL221_SOFT_TISSUE"}}
+{"question_id": "GEL2-0226", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RPE1SS6_ENGINEERED (Eye) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ODF1: gene effect = -0.044, dependency probability = 0.040 \u2192 classified as non-essential", "gold_answer": "ODF1", "gold_category": "depmap", "gold_extraction": {"cell_line": "RPE1SS6_ENGINEERED", "screen_type": "CRISPR", "genes": [{"gene_name": "ODF1", "cell_line": "RPE1SS6_ENGINEERED", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0436710407867292}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ODF1"], "cell_line": "RPE1SS6_ENGINEERED"}}
+{"question_id": "GEL2-0227", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TOV112D_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- EGR1: gene effect = 0.071, dependency probability = 0.006 \u2192 classified as non-essential\n- NR4A2: gene effect = -0.008, dependency probability = 0.018 \u2192 classified as non-essential", "gold_answer": "EGR1", "gold_category": "depmap", "gold_extraction": {"cell_line": "TOV112D_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "EGR1", "cell_line": "TOV112D_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0705102251476776}, {"gene_name": "NR4A2", "cell_line": "TOV112D_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0081328683043759}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["EGR1", "NR4A2"], "cell_line": "TOV112D_OVARY"}}
+{"question_id": "GEL2-0228", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SW403_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GMPR2: gene effect = -0.001, dependency probability = 0.020 \u2192 classified as non-essential\n- EIF3F: gene effect = -0.090, dependency probability = 0.051 \u2192 classified as non-essential", "gold_answer": "GMPR2", "gold_category": "depmap", "gold_extraction": {"cell_line": "SW403_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "GMPR2", "cell_line": "SW403_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0009999717332828}, {"gene_name": "EIF3F", "cell_line": "SW403_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0896297250290569}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["GMPR2", "EIF3F"], "cell_line": "SW403_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0229", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TM31_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZRANB2: gene effect = -0.327, dependency probability = 0.277 \u2192 classified as non-essential\n- CD300C: gene effect = 0.168, dependency probability = 0.007 \u2192 classified as non-essential\n- EPC1: gene effect = -0.223, dependency probability = 0.195 \u2192 classified as non-essential", "gold_answer": "ZRANB2", "gold_category": "depmap", "gold_extraction": {"cell_line": "TM31_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "ZRANB2", "cell_line": "TM31_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3273375727634838}, {"gene_name": "CD300C", "cell_line": "TM31_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1675683760929326}, {"gene_name": "EPC1", "cell_line": "TM31_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2227447391063562}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["ZRANB2", "CD300C", "EPC1"], "cell_line": "TM31_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0230", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in G401_SOFT_TISSUE (Kidney) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SLC13A4: gene effect = 0.027, dependency probability = 0.014 \u2192 classified as non-essential", "gold_answer": "SLC13A4", "gold_category": "depmap", "gold_extraction": {"cell_line": "G401_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "SLC13A4", "cell_line": "G401_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.027278248420704}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SLC13A4"], "cell_line": "G401_SOFT_TISSUE"}}
+{"question_id": "GEL2-0231", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in FU97_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FAM83D: gene effect = -0.348, dependency probability = 0.333 \u2192 classified as non-essential", "gold_answer": "FAM83D", "gold_category": "depmap", "gold_extraction": {"cell_line": "FU97_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "FAM83D", "cell_line": "FU97_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3478315209218513}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["FAM83D"], "cell_line": "FU97_STOMACH"}}
+{"question_id": "GEL2-0232", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TC205_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF160: gene effect = -0.023, dependency probability = 0.024 \u2192 classified as non-essential\n- SOX17: gene effect = -0.009, dependency probability = 0.022 \u2192 classified as non-essential", "gold_answer": "ZNF160", "gold_category": "depmap", "gold_extraction": {"cell_line": "TC205_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF160", "cell_line": "TC205_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0233551839741299}, {"gene_name": "SOX17", "cell_line": "TC205_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0087054603071499}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ZNF160", "SOX17"], "cell_line": "TC205_BONE"}}
+{"question_id": "GEL2-0233", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in 538MGBA_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRDM2: gene effect = 0.062, dependency probability = 0.013 \u2192 classified as non-essential\n- SIPA1L1: gene effect = -0.066, dependency probability = 0.046 \u2192 classified as non-essential", "gold_answer": "PRDM2", "gold_category": "depmap", "gold_extraction": {"cell_line": "538MGBA_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "PRDM2", "cell_line": "538MGBA_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0616302526181995}, {"gene_name": "SIPA1L1", "cell_line": "538MGBA_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0660891312675507}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PRDM2", "SIPA1L1"], "cell_line": "538MGBA_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0234", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNUC4_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SPAG9: gene effect = -0.220, dependency probability = 0.104 \u2192 classified as non-essential\n- NPFFR2: gene effect = 0.057, dependency probability = 0.009 \u2192 classified as non-essential\n- OR5H15: gene effect = -0.031, dependency probability = 0.022 \u2192 classified as non-essential", "gold_answer": "SPAG9", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNUC4_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "SPAG9", "cell_line": "SNUC4_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2198727701028028}, {"gene_name": "NPFFR2", "cell_line": "SNUC4_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0566333317986168}, {"gene_name": "OR5H15", "cell_line": "SNUC4_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0308312291339686}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["SPAG9", "NPFFR2", "OR5H15"], "cell_line": "SNUC4_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0235", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TE4_OESOPHAGUS (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CRH: gene effect = -0.164, dependency probability = 0.089 \u2192 classified as non-essential", "gold_answer": "CRH", "gold_category": "depmap", "gold_extraction": {"cell_line": "TE4_OESOPHAGUS", "screen_type": "CRISPR", "genes": [{"gene_name": "CRH", "cell_line": "TE4_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1637251432373675}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CRH"], "cell_line": "TE4_OESOPHAGUS"}}
+{"question_id": "GEL2-0236", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU668_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MLLT10: gene effect = 0.097, dependency probability = 0.007 \u2192 classified as non-essential", "gold_answer": "MLLT10", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU668_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "MLLT10", "cell_line": "SNU668_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.097443758689661}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MLLT10"], "cell_line": "SNU668_STOMACH"}}
+{"question_id": "GEL2-0237", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in IALM_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- WAC: gene effect = -0.535, dependency probability = 0.310 \u2192 classified as non-essential\n- MYO10: gene effect = -0.129, dependency probability = 0.072 \u2192 classified as non-essential", "gold_answer": "WAC", "gold_category": "depmap", "gold_extraction": {"cell_line": "IALM_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "WAC", "cell_line": "IALM_LUNG", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.535461765707272}, {"gene_name": "MYO10", "cell_line": "IALM_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1285994717312901}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["WAC", "MYO10"], "cell_line": "IALM_LUNG"}}
+{"question_id": "GEL2-0238", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OSRC2_KIDNEY (Kidney) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TMEM225: gene effect = 0.118, dependency probability = 0.009 \u2192 classified as non-essential\n- ECT2L: gene effect = -0.198, dependency probability = 0.097 \u2192 classified as non-essential", "gold_answer": "TMEM225", "gold_category": "depmap", "gold_extraction": {"cell_line": "OSRC2_KIDNEY", "screen_type": "CRISPR", "genes": [{"gene_name": "TMEM225", "cell_line": "OSRC2_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1178656029593075}, {"gene_name": "ECT2L", "cell_line": "OSRC2_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.198277317248832}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["TMEM225", "ECT2L"], "cell_line": "OSRC2_KIDNEY"}}
+{"question_id": "GEL2-0239", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- BAD: gene effect = -0.275, dependency probability = 0.172 \u2192 classified as non-essential\n- KAT7: gene effect = -0.402, dependency probability = 0.500 \u2192 classified as non-essential\n- PPARG: gene effect = 0.223, dependency probability = 0.003 \u2192 classified as non-essential", "gold_answer": "BAD", "gold_category": "depmap", "gold_extraction": {"cell_line": "CI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "BAD", "cell_line": "CI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.275321963875903}, {"gene_name": "KAT7", "cell_line": "CI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4024788164169288}, {"gene_name": "PPARG", "cell_line": "CI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.222905414867544}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["BAD", "KAT7", "PPARG"], "cell_line": "CI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0240", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH1666_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DEK: gene effect = 0.243, dependency probability = 0.003 \u2192 classified as non-essential", "gold_answer": "DEK", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH1666_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "DEK", "cell_line": "NCIH1666_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2426472071402088}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DEK"], "cell_line": "NCIH1666_LUNG"}}
+{"question_id": "GEL2-0241", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC461_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ABHD17B: gene effect = 0.043, dependency probability = 0.012 \u2192 classified as non-essential", "gold_answer": "ABHD17B", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC461_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "ABHD17B", "cell_line": "HCC461_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0433504603019779}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ABHD17B"], "cell_line": "HCC461_LUNG"}}
+{"question_id": "GEL2-0242", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH23_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ASTN1: gene effect = 0.016, dependency probability = 0.019 \u2192 classified as non-essential\n- TMEM183A: gene effect = -0.386, dependency probability = 0.281 \u2192 classified as non-essential", "gold_answer": "ASTN1", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH23_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "ASTN1", "cell_line": "NCIH23_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0157291240719421}, {"gene_name": "TMEM183A", "cell_line": "NCIH23_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3858605074658338}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ASTN1", "TMEM183A"], "cell_line": "NCIH23_LUNG"}}
+{"question_id": "GEL2-0243", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NZOV9_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF8: gene effect = -0.096, dependency probability = 0.031 \u2192 classified as non-essential\n- TP53INP1: gene effect = 0.114, dependency probability = 0.010 \u2192 classified as non-essential", "gold_answer": "ZNF8", "gold_category": "depmap", "gold_extraction": {"cell_line": "NZOV9_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF8", "cell_line": "NZOV9_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0962006846208231}, {"gene_name": "TP53INP1", "cell_line": "NZOV9_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1144529931619515}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ZNF8", "TP53INP1"], "cell_line": "NZOV9_OVARY"}}
+{"question_id": "GEL2-0244", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CORL279_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TIMP3: gene effect = 0.110, dependency probability = 0.011 \u2192 classified as non-essential\n- ZNF444: gene effect = 0.115, dependency probability = 0.004 \u2192 classified as non-essential\n- FAM180A: gene effect = -0.178, dependency probability = 0.044 \u2192 classified as non-essential", "gold_answer": "TIMP3", "gold_category": "depmap", "gold_extraction": {"cell_line": "CORL279_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "TIMP3", "cell_line": "CORL279_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1099973797951601}, {"gene_name": "ZNF444", "cell_line": "CORL279_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1149993379616685}, {"gene_name": "FAM180A", "cell_line": "CORL279_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1782322277746868}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["TIMP3", "ZNF444", "FAM180A"], "cell_line": "CORL279_LUNG"}}
+{"question_id": "GEL2-0245", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SF295_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SPRN: gene effect = -0.015, dependency probability = 0.027 \u2192 classified as non-essential", "gold_answer": "SPRN", "gold_category": "depmap", "gold_extraction": {"cell_line": "SF295_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "SPRN", "cell_line": "SF295_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0150079997335017}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SPRN"], "cell_line": "SF295_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0246", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MEL270_UVEA (Eye) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- AKTIP: gene effect = 0.270, dependency probability = 0.005 \u2192 classified as non-essential", "gold_answer": "AKTIP", "gold_category": "depmap", "gold_extraction": {"cell_line": "MEL270_UVEA", "screen_type": "CRISPR", "genes": [{"gene_name": "AKTIP", "cell_line": "MEL270_UVEA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2695432577968488}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["AKTIP"], "cell_line": "MEL270_UVEA"}}
+{"question_id": "GEL2-0247", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OE33_OESOPHAGUS (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- LRP2BP: gene effect = 0.042, dependency probability = 0.024 \u2192 classified as non-essential\n- OR8K1: gene effect = -0.108, dependency probability = 0.057 \u2192 classified as non-essential", "gold_answer": "LRP2BP", "gold_category": "depmap", "gold_extraction": {"cell_line": "OE33_OESOPHAGUS", "screen_type": "CRISPR", "genes": [{"gene_name": "LRP2BP", "cell_line": "OE33_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0417891730941301}, {"gene_name": "OR8K1", "cell_line": "OE33_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1075058463675208}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["LRP2BP", "OR8K1"], "cell_line": "OE33_OESOPHAGUS"}}
+{"question_id": "GEL2-0248", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- LGI3: gene effect = 0.284, dependency probability = 0.001 \u2192 classified as non-essential\n- UGT1A7: gene effect = 0.017, dependency probability = 0.017 \u2192 classified as non-essential", "gold_answer": "LGI3", "gold_category": "depmap", "gold_extraction": {"cell_line": "JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "LGI3", "cell_line": "JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2843576644910423}, {"gene_name": "UGT1A7", "cell_line": "JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0166972273624872}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["LGI3", "UGT1A7"], "cell_line": "JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0249", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC95_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- COL2A1: gene effect = 0.011, dependency probability = 0.014 \u2192 classified as non-essential\n- ARHGAP24: gene effect = 0.012, dependency probability = 0.019 \u2192 classified as non-essential\n- PKD2L1: gene effect = -0.084, dependency probability = 0.054 \u2192 classified as non-essential", "gold_answer": "COL2A1", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC95_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "COL2A1", "cell_line": "HCC95_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0106763683354846}, {"gene_name": "ARHGAP24", "cell_line": "HCC95_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0116131988379155}, {"gene_name": "PKD2L1", "cell_line": "HCC95_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0838999630763709}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["COL2A1", "ARHGAP24", "PKD2L1"], "cell_line": "HCC95_LUNG"}}
+{"question_id": "GEL2-0250", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SET2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SETD3: gene effect = 0.139, dependency probability = 0.006 \u2192 classified as non-essential", "gold_answer": "SETD3", "gold_category": "depmap", "gold_extraction": {"cell_line": "SET2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "SETD3", "cell_line": "SET2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1388570047364804}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SETD3"], "cell_line": "SET2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0251", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RD_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PPFIA2: gene effect = -0.278, dependency probability = 0.224 \u2192 classified as non-essential", "gold_answer": "PPFIA2", "gold_category": "depmap", "gold_extraction": {"cell_line": "RD_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "PPFIA2", "cell_line": "RD_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2779063580572019}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PPFIA2"], "cell_line": "RD_SOFT_TISSUE"}}
+{"question_id": "GEL2-0252", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in ICC106_BILIARY_TRACT (Biliary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF106: gene effect = -0.063, dependency probability = 0.044 \u2192 classified as non-essential\n- ZNF416: gene effect = -0.096, dependency probability = 0.051 \u2192 classified as non-essential", "gold_answer": "ZNF106", "gold_category": "depmap", "gold_extraction": {"cell_line": "ICC106_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF106", "cell_line": "ICC106_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0629045954213956}, {"gene_name": "ZNF416", "cell_line": "ICC106_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0961624607942734}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ZNF106", "ZNF416"], "cell_line": "ICC106_BILIARY_TRACT"}}
+{"question_id": "GEL2-0253", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CAKI2_KIDNEY (Kidney) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HP1BP3: gene effect = 0.079, dependency probability = 0.018 \u2192 classified as non-essential\n- TTC32: gene effect = 0.024, dependency probability = 0.017 \u2192 classified as non-essential", "gold_answer": "HP1BP3", "gold_category": "depmap", "gold_extraction": {"cell_line": "CAKI2_KIDNEY", "screen_type": "CRISPR", "genes": [{"gene_name": "HP1BP3", "cell_line": "CAKI2_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0787463304736266}, {"gene_name": "TTC32", "cell_line": "CAKI2_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0241271066135239}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["HP1BP3", "TTC32"], "cell_line": "CAKI2_KIDNEY"}}
+{"question_id": "GEL2-0254", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NP3_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- EEPD1: gene effect = 0.191, dependency probability = 0.004 \u2192 classified as non-essential\n- FHIP2B: gene effect = 0.020, dependency probability = 0.020 \u2192 classified as non-essential\n- CEP41: gene effect = 0.251, dependency probability = 0.002 \u2192 classified as non-essential", "gold_answer": "EEPD1", "gold_category": "depmap", "gold_extraction": {"cell_line": "NP3_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "EEPD1", "cell_line": "NP3_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1914915140537126}, {"gene_name": "FHIP2B", "cell_line": "NP3_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0199710077262732}, {"gene_name": "CEP41", "cell_line": "NP3_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2510323000629426}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["EEPD1", "FHIP2B", "CEP41"], "cell_line": "NP3_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0255", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SHMAC5_PROSTATE (Prostate) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SLC25A39: gene effect = 0.150, dependency probability = 0.005 \u2192 classified as non-essential", "gold_answer": "SLC25A39", "gold_category": "depmap", "gold_extraction": {"cell_line": "SHMAC5_PROSTATE", "screen_type": "CRISPR", "genes": [{"gene_name": "SLC25A39", "cell_line": "SHMAC5_PROSTATE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1500350251857734}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SLC25A39"], "cell_line": "SHMAC5_PROSTATE"}}
+{"question_id": "GEL2-0256", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SCC9_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- EDNRA: gene effect = 0.037, dependency probability = 0.017 \u2192 classified as non-essential", "gold_answer": "EDNRA", "gold_category": "depmap", "gold_extraction": {"cell_line": "SCC9_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "EDNRA", "cell_line": "SCC9_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0373250506229464}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["EDNRA"], "cell_line": "SCC9_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0257", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in LN464_CENTRAL_NERVOUS_SYSTEM (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FAM124A: gene effect = 0.004, dependency probability = 0.017 \u2192 classified as non-essential\n- GOLGA8M: gene effect = -0.374, dependency probability = 0.282 \u2192 classified as non-essential", "gold_answer": "FAM124A", "gold_category": "depmap", "gold_extraction": {"cell_line": "LN464_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "FAM124A", "cell_line": "LN464_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0041924669030459}, {"gene_name": "GOLGA8M", "cell_line": "LN464_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3741325942401532}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["FAM124A", "GOLGA8M"], "cell_line": "LN464_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0258", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HEL9217_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SLC20A1: gene effect = -0.230, dependency probability = 0.098 \u2192 classified as non-essential\n- XKR8: gene effect = -0.246, dependency probability = 0.115 \u2192 classified as non-essential", "gold_answer": "SLC20A1", "gold_category": "depmap", "gold_extraction": {"cell_line": "HEL9217_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "SLC20A1", "cell_line": "HEL9217_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2297367818340422}, {"gene_name": "XKR8", "cell_line": "HEL9217_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2461095651892143}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["SLC20A1", "XKR8"], "cell_line": "HEL9217_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0259", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SKNEP1_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SKIC8: gene effect = -0.773, dependency probability = 0.903 \u2192 classified as non-essential\n- FOXO4: gene effect = -0.116, dependency probability = 0.077 \u2192 classified as non-essential\n- HAT1: gene effect = -0.026, dependency probability = 0.032 \u2192 classified as non-essential", "gold_answer": "SKIC8", "gold_category": "depmap", "gold_extraction": {"cell_line": "SKNEP1_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "SKIC8", "cell_line": "SKNEP1_BONE", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.7727199605753656}, {"gene_name": "FOXO4", "cell_line": "SKNEP1_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.115890257342766}, {"gene_name": "HAT1", "cell_line": "SKNEP1_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0262597272094734}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["SKIC8", "FOXO4", "HAT1"], "cell_line": "SKNEP1_BONE"}}
+{"question_id": "GEL2-0260", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in nan (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NNMT: gene effect = -0.011, dependency probability = 0.034 \u2192 classified as non-essential", "gold_answer": "NNMT", "gold_category": "depmap", "gold_extraction": {"cell_line": NaN, "screen_type": "CRISPR", "genes": [{"gene_name": "NNMT", "cell_line": NaN, "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0113301821532655}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["NNMT"], "cell_line": NaN}}
+{"question_id": "GEL2-0261", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in GCIY_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SIAE: gene effect = 0.190, dependency probability = 0.001 \u2192 classified as non-essential", "gold_answer": "SIAE", "gold_category": "depmap", "gold_extraction": {"cell_line": "GCIY_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "SIAE", "cell_line": "GCIY_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.190472086792881}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SIAE"], "cell_line": "GCIY_STOMACH"}}
+{"question_id": "GEL2-0262", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in FTC133_THYROID (Thyroid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ARL6IP1: gene effect = -0.027, dependency probability = 0.026 \u2192 classified as non-essential\n- HSPBP1: gene effect = 0.071, dependency probability = 0.010 \u2192 classified as non-essential", "gold_answer": "ARL6IP1", "gold_category": "depmap", "gold_extraction": {"cell_line": "FTC133_THYROID", "screen_type": "CRISPR", "genes": [{"gene_name": "ARL6IP1", "cell_line": "FTC133_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0267873258955131}, {"gene_name": "HSPBP1", "cell_line": "FTC133_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.070955772734594}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ARL6IP1", "HSPBP1"], "cell_line": "FTC133_THYROID"}}
+{"question_id": "GEL2-0263", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCT116_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- B4GALNT4: gene effect = 0.013, dependency probability = 0.019 \u2192 classified as non-essential\n- JPH3: gene effect = 0.002, dependency probability = 0.017 \u2192 classified as non-essential", "gold_answer": "B4GALNT4", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCT116_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "B4GALNT4", "cell_line": "HCT116_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0129709434022956}, {"gene_name": "JPH3", "cell_line": "HCT116_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0022084814689617}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["B4GALNT4", "JPH3"], "cell_line": "HCT116_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0264", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NP3_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- EFNB3: gene effect = -0.150, dependency probability = 0.079 \u2192 classified as non-essential\n- MIPOL1: gene effect = -0.210, dependency probability = 0.110 \u2192 classified as non-essential\n- FCRL4: gene effect = 0.018, dependency probability = 0.016 \u2192 classified as non-essential", "gold_answer": "EFNB3", "gold_category": "depmap", "gold_extraction": {"cell_line": "NP3_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "EFNB3", "cell_line": "NP3_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1503845473950812}, {"gene_name": "MIPOL1", "cell_line": "NP3_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2099695531925814}, {"gene_name": "FCRL4", "cell_line": "NP3_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0182615443401844}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["EFNB3", "MIPOL1", "FCRL4"], "cell_line": "NP3_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0265", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MOXD1: gene effect = 0.137, dependency probability = 0.003 \u2192 classified as non-essential", "gold_answer": "MOXD1", "gold_category": "depmap", "gold_extraction": {"cell_line": "SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "MOXD1", "cell_line": "SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1368116829803544}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MOXD1"], "cell_line": "SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0266", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CHLA90_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CLDN3: gene effect = 0.566, dependency probability = 0.000 \u2192 classified as non-essential", "gold_answer": "CLDN3", "gold_category": "depmap", "gold_extraction": {"cell_line": "CHLA90_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "CLDN3", "cell_line": "CHLA90_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.566144017969941}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CLDN3"], "cell_line": "CHLA90_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0267", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TUHR10TKB_KIDNEY (Kidney) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- WDR77: gene effect = 0.054, dependency probability = 0.028 \u2192 classified as non-essential\n- DERL2: gene effect = -0.127, dependency probability = 0.052 \u2192 classified as non-essential", "gold_answer": "WDR77", "gold_category": "depmap", "gold_extraction": {"cell_line": "TUHR10TKB_KIDNEY", "screen_type": "CRISPR", "genes": [{"gene_name": "WDR77", "cell_line": "TUHR10TKB_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.054002152697216}, {"gene_name": "DERL2", "cell_line": "TUHR10TKB_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.127339885194263}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["WDR77", "DERL2"], "cell_line": "TUHR10TKB_KIDNEY"}}
+{"question_id": "GEL2-0268", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JOPACA1_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- IRAK3: gene effect = -0.028, dependency probability = 0.036 \u2192 classified as non-essential\n- COL15A1: gene effect = 0.024, dependency probability = 0.010 \u2192 classified as non-essential", "gold_answer": "IRAK3", "gold_category": "depmap", "gold_extraction": {"cell_line": "JOPACA1_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "IRAK3", "cell_line": "JOPACA1_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.028010371997957}, {"gene_name": "COL15A1", "cell_line": "JOPACA1_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0235062007582686}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["IRAK3", "COL15A1"], "cell_line": "JOPACA1_PANCREAS"}}
+{"question_id": "GEL2-0269", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HSOS1_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- EID1: gene effect = 0.174, dependency probability = 0.005 \u2192 classified as non-essential\n- PITPNM1: gene effect = -0.209, dependency probability = 0.096 \u2192 classified as non-essential\n- HERC4: gene effect = -0.147, dependency probability = 0.059 \u2192 classified as non-essential", "gold_answer": "EID1", "gold_category": "depmap", "gold_extraction": {"cell_line": "HSOS1_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "EID1", "cell_line": "HSOS1_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1736062778190965}, {"gene_name": "PITPNM1", "cell_line": "HSOS1_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.208829028701848}, {"gene_name": "HERC4", "cell_line": "HSOS1_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1474305306971898}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["EID1", "PITPNM1", "HERC4"], "cell_line": "HSOS1_BONE"}}
+{"question_id": "GEL2-0270", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OCUG1_BILIARY_TRACT (Biliary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRRT1B: gene effect = 0.204, dependency probability = 0.008 \u2192 classified as non-essential", "gold_answer": "PRRT1B", "gold_category": "depmap", "gold_extraction": {"cell_line": "OCUG1_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "PRRT1B", "cell_line": "OCUG1_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2041815814017931}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PRRT1B"], "cell_line": "OCUG1_BILIARY_TRACT"}}
+{"question_id": "GEL2-0271", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OMM25_UVEA (Eye) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KCNQ1: gene effect = 0.101, dependency probability = 0.007 \u2192 classified as non-essential", "gold_answer": "KCNQ1", "gold_category": "depmap", "gold_extraction": {"cell_line": "OMM25_UVEA", "screen_type": "CRISPR", "genes": [{"gene_name": "KCNQ1", "cell_line": "OMM25_UVEA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.100647590616553}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["KCNQ1"], "cell_line": "OMM25_UVEA"}}
+{"question_id": "GEL2-0272", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU251_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ROPN1B: gene effect = 0.043, dependency probability = 0.011 \u2192 classified as non-essential\n- TBC1D2: gene effect = 0.063, dependency probability = 0.014 \u2192 classified as non-essential", "gold_answer": "ROPN1B", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU251_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "ROPN1B", "cell_line": "SNU251_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0434113619420183}, {"gene_name": "TBC1D2", "cell_line": "SNU251_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0633585139567557}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ROPN1B", "TBC1D2"], "cell_line": "SNU251_OVARY"}}
+{"question_id": "GEL2-0273", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in IM95_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ALG14: gene effect = -0.376, dependency probability = 0.299 \u2192 classified as non-essential\n- NLRP2B: gene effect = 0.102, dependency probability = 0.004 \u2192 classified as non-essential", "gold_answer": "ALG14", "gold_category": "depmap", "gold_extraction": {"cell_line": "IM95_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "ALG14", "cell_line": "IM95_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3759732947122292}, {"gene_name": "NLRP2B", "cell_line": "IM95_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1021213360073286}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ALG14", "NLRP2B"], "cell_line": "IM95_STOMACH"}}
+{"question_id": "GEL2-0274", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PANC0203_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- IRF1: gene effect = -0.020, dependency probability = 0.028 \u2192 classified as non-essential\n- PARP1: gene effect = -0.213, dependency probability = 0.136 \u2192 classified as non-essential\n- LRIG2: gene effect = -0.068, dependency probability = 0.036 \u2192 classified as non-essential", "gold_answer": "IRF1", "gold_category": "depmap", "gold_extraction": {"cell_line": "PANC0203_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "IRF1", "cell_line": "PANC0203_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0202479253932989}, {"gene_name": "PARP1", "cell_line": "PANC0203_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2133413864214035}, {"gene_name": "LRIG2", "cell_line": "PANC0203_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0678527829239299}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["IRF1", "PARP1", "LRIG2"], "cell_line": "PANC0203_PANCREAS"}}
+{"question_id": "GEL2-0275", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DLGAP3: gene effect = 0.148, dependency probability = 0.006 \u2192 classified as non-essential", "gold_answer": "DLGAP3", "gold_category": "depmap", "gold_extraction": {"cell_line": "K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "DLGAP3", "cell_line": "K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1475979516125887}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DLGAP3"], "cell_line": "K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0276", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MM160113_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MAPK1: gene effect = -0.272, dependency probability = 0.148 \u2192 classified as non-essential", "gold_answer": "MAPK1", "gold_category": "depmap", "gold_extraction": {"cell_line": "MM160113_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "MAPK1", "cell_line": "MM160113_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2717146847147355}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MAPK1"], "cell_line": "MM160113_SKIN"}}
+{"question_id": "GEL2-0277", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CAMA1_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KTI12: gene effect = -0.162, dependency probability = 0.117 \u2192 classified as non-essential\n- CDK7: gene effect = -0.663, dependency probability = 0.734 \u2192 classified as non-essential", "gold_answer": "KTI12", "gold_category": "depmap", "gold_extraction": {"cell_line": "CAMA1_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "KTI12", "cell_line": "CAMA1_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.162074150195781}, {"gene_name": "CDK7", "cell_line": "CAMA1_BREAST", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.6630037355301233}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["KTI12", "CDK7"], "cell_line": "CAMA1_BREAST"}}
+{"question_id": "GEL2-0278", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MHHES1_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KCNC4: gene effect = -0.326, dependency probability = 0.283 \u2192 classified as non-essential\n- PLPP7: gene effect = 0.121, dependency probability = 0.018 \u2192 classified as non-essential", "gold_answer": "KCNC4", "gold_category": "depmap", "gold_extraction": {"cell_line": "MHHES1_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "KCNC4", "cell_line": "MHHES1_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3261708195686528}, {"gene_name": "PLPP7", "cell_line": "MHHES1_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1211703684358311}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["KCNC4", "PLPP7"], "cell_line": "MHHES1_BONE"}}
+{"question_id": "GEL2-0279", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TANOUE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRDM4: gene effect = 0.059, dependency probability = 0.007 \u2192 classified as non-essential\n- MEF2C: gene effect = 0.114, dependency probability = 0.005 \u2192 classified as non-essential\n- ADH6: gene effect = -0.292, dependency probability = 0.193 \u2192 classified as non-essential", "gold_answer": "PRDM4", "gold_category": "depmap", "gold_extraction": {"cell_line": "TANOUE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "PRDM4", "cell_line": "TANOUE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0593993421256219}, {"gene_name": "MEF2C", "cell_line": "TANOUE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1143780647852912}, {"gene_name": "ADH6", "cell_line": "TANOUE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2920101440448043}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["PRDM4", "MEF2C", "ADH6"], "cell_line": "TANOUE_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0280", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SW1463_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DTX2: gene effect = -0.229, dependency probability = 0.149 \u2192 classified as non-essential", "gold_answer": "DTX2", "gold_category": "depmap", "gold_extraction": {"cell_line": "SW1463_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "DTX2", "cell_line": "SW1463_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2294694080957622}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DTX2"], "cell_line": "SW1463_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0281", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MEL285_UVEA (Eye) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SOX13: gene effect = 0.094, dependency probability = 0.007 \u2192 classified as non-essential", "gold_answer": "SOX13", "gold_category": "depmap", "gold_extraction": {"cell_line": "MEL285_UVEA", "screen_type": "CRISPR", "genes": [{"gene_name": "SOX13", "cell_line": "MEL285_UVEA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0935611418332572}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SOX13"], "cell_line": "MEL285_UVEA"}}
+{"question_id": "GEL2-0282", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in BICR6_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ASB13: gene effect = 0.023, dependency probability = 0.017 \u2192 classified as non-essential\n- VSNL1: gene effect = 0.113, dependency probability = 0.006 \u2192 classified as non-essential", "gold_answer": "ASB13", "gold_category": "depmap", "gold_extraction": {"cell_line": "BICR6_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "ASB13", "cell_line": "BICR6_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0234220811407952}, {"gene_name": "VSNL1", "cell_line": "BICR6_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1134787787331591}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ASB13", "VSNL1"], "cell_line": "BICR6_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0283", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in IM9_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ADAMTS3: gene effect = -0.073, dependency probability = 0.034 \u2192 classified as non-essential\n- ANAPC4: gene effect = -0.238, dependency probability = 0.114 \u2192 classified as non-essential", "gold_answer": "ADAMTS3", "gold_category": "depmap", "gold_extraction": {"cell_line": "IM9_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "ADAMTS3", "cell_line": "IM9_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0733873624231661}, {"gene_name": "ANAPC4", "cell_line": "IM9_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2381776763641588}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ADAMTS3", "ANAPC4"], "cell_line": "IM9_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0284", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in GSU_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SPTBN1: gene effect = 0.322, dependency probability = 0.001 \u2192 classified as non-essential\n- MCEE: gene effect = -0.164, dependency probability = 0.068 \u2192 classified as non-essential\n- MACROD1: gene effect = -0.163, dependency probability = 0.073 \u2192 classified as non-essential", "gold_answer": "SPTBN1", "gold_category": "depmap", "gold_extraction": {"cell_line": "GSU_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "SPTBN1", "cell_line": "GSU_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.3222897346763745}, {"gene_name": "MCEE", "cell_line": "GSU_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1640845434907107}, {"gene_name": "MACROD1", "cell_line": "GSU_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.162534135992956}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["SPTBN1", "MCEE", "MACROD1"], "cell_line": "GSU_STOMACH"}}
+{"question_id": "GEL2-0285", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SKUT1_SOFT_TISSUE (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- OR6C68: gene effect = -0.001, dependency probability = 0.017 \u2192 classified as non-essential", "gold_answer": "OR6C68", "gold_category": "depmap", "gold_extraction": {"cell_line": "SKUT1_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "OR6C68", "cell_line": "SKUT1_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0013678559749166}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["OR6C68"], "cell_line": "SKUT1_SOFT_TISSUE"}}
+{"question_id": "GEL2-0286", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH446_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PPP1R14B: gene effect = -0.352, dependency probability = 0.243 \u2192 classified as non-essential", "gold_answer": "PPP1R14B", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH446_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "PPP1R14B", "cell_line": "NCIH446_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3516199101730187}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PPP1R14B"], "cell_line": "NCIH446_LUNG"}}
+{"question_id": "GEL2-0287", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in H376_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- COX15: gene effect = -0.005, dependency probability = 0.023 \u2192 classified as non-essential\n- LRRC37A3: gene effect = -0.483, dependency probability = 0.488 \u2192 classified as non-essential", "gold_answer": "COX15", "gold_category": "depmap", "gold_extraction": {"cell_line": "H376_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "COX15", "cell_line": "H376_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0045537891143211}, {"gene_name": "LRRC37A3", "cell_line": "H376_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4833922881455035}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["COX15", "LRRC37A3"], "cell_line": "H376_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0288", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- OR4C6: gene effect = 0.208, dependency probability = 0.005 \u2192 classified as non-essential\n- GDA: gene effect = 0.278, dependency probability = 0.002 \u2192 classified as non-essential", "gold_answer": "OR4C6", "gold_category": "depmap", "gold_extraction": {"cell_line": "KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "OR4C6", "cell_line": "KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2077588738386598}, {"gene_name": "GDA", "cell_line": "KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2775068872017823}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["OR4C6", "GDA"], "cell_line": "KARPAS422_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0289", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DCDC2B: gene effect = -0.090, dependency probability = 0.045 \u2192 classified as non-essential\n- SCAF8: gene effect = -0.270, dependency probability = 0.166 \u2192 classified as non-essential\n- FAM50A: gene effect = 0.016, dependency probability = 0.020 \u2192 classified as non-essential", "gold_answer": "DCDC2B", "gold_category": "depmap", "gold_extraction": {"cell_line": "KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "DCDC2B", "cell_line": "KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0896049768917245}, {"gene_name": "SCAF8", "cell_line": "KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.270150732334418}, {"gene_name": "FAM50A", "cell_line": "KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0158203406280732}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["DCDC2B", "SCAF8", "FAM50A"], "cell_line": "KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0290", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NRH-GCT2 (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HCFC1R1: gene effect = -0.370, dependency probability = 0.400 \u2192 classified as non-essential", "gold_answer": "HCFC1R1", "gold_category": "depmap", "gold_extraction": {"cell_line": "NRH-GCT2", "screen_type": "CRISPR", "genes": [{"gene_name": "HCFC1R1", "cell_line": "NRH-GCT2", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3700311553247205}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["HCFC1R1"], "cell_line": "NRH-GCT2"}}
+{"question_id": "GEL2-0291", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UPCISCC200_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- P2RX1: gene effect = -0.105, dependency probability = 0.051 \u2192 classified as non-essential", "gold_answer": "P2RX1", "gold_category": "depmap", "gold_extraction": {"cell_line": "UPCISCC200_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "P2RX1", "cell_line": "UPCISCC200_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1047908161600245}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["P2RX1"], "cell_line": "UPCISCC200_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0292", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NO36_LUNG (Pleura) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FABP7: gene effect = 0.088, dependency probability = 0.007 \u2192 classified as non-essential\n- UGT1A5: gene effect = -0.053, dependency probability = 0.032 \u2192 classified as non-essential", "gold_answer": "FABP7", "gold_category": "depmap", "gold_extraction": {"cell_line": "NO36_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "FABP7", "cell_line": "NO36_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0884289558404235}, {"gene_name": "UGT1A5", "cell_line": "NO36_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0525858831044576}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["FABP7", "UGT1A5"], "cell_line": "NO36_LUNG"}}
+{"question_id": "GEL2-0293", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in COV362_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- UBA6: gene effect = -0.275, dependency probability = 0.120 \u2192 classified as non-essential\n- ZNF559: gene effect = -0.208, dependency probability = 0.139 \u2192 classified as non-essential", "gold_answer": "UBA6", "gold_category": "depmap", "gold_extraction": {"cell_line": "COV362_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "UBA6", "cell_line": "COV362_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2750606278765933}, {"gene_name": "ZNF559", "cell_line": "COV362_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2082657913587344}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["UBA6", "ZNF559"], "cell_line": "COV362_OVARY"}}
+{"question_id": "GEL2-0294", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OAW42_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZHX1: gene effect = 0.062, dependency probability = 0.018 \u2192 classified as non-essential\n- UBN1: gene effect = -0.263, dependency probability = 0.147 \u2192 classified as non-essential\n- AP2M1: gene effect = -0.380, dependency probability = 0.297 \u2192 classified as non-essential", "gold_answer": "ZHX1", "gold_category": "depmap", "gold_extraction": {"cell_line": "OAW42_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "ZHX1", "cell_line": "OAW42_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.062427039773088}, {"gene_name": "UBN1", "cell_line": "OAW42_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2626666331201323}, {"gene_name": "AP2M1", "cell_line": "OAW42_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3799603335235973}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["ZHX1", "UBN1", "AP2M1"], "cell_line": "OAW42_OVARY"}}
+{"question_id": "GEL2-0295", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KS1_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- H2AC8: gene effect = -0.315, dependency probability = 0.137 \u2192 classified as non-essential", "gold_answer": "H2AC8", "gold_category": "depmap", "gold_extraction": {"cell_line": "KS1_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "H2AC8", "cell_line": "KS1_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.314741274563258}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["H2AC8"], "cell_line": "KS1_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0296", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RCM1_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FUOM: gene effect = 0.116, dependency probability = 0.011 \u2192 classified as non-essential", "gold_answer": "FUOM", "gold_category": "depmap", "gold_extraction": {"cell_line": "RCM1_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "FUOM", "cell_line": "RCM1_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1161992615069874}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["FUOM"], "cell_line": "RCM1_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0297", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH322_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CIMIP4: gene effect = -0.041, dependency probability = 0.022 \u2192 classified as non-essential\n- ANGPT2: gene effect = 0.043, dependency probability = 0.019 \u2192 classified as non-essential", "gold_answer": "CIMIP4", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH322_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "CIMIP4", "cell_line": "NCIH322_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0405151467640056}, {"gene_name": "ANGPT2", "cell_line": "NCIH322_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0426020096811975}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CIMIP4", "ANGPT2"], "cell_line": "NCIH322_LUNG"}}
+{"question_id": "GEL2-0298", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SCC9_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SALL4: gene effect = -0.253, dependency probability = 0.182 \u2192 classified as non-essential\n- KRTAP4-8: gene effect = -0.075, dependency probability = 0.063 \u2192 classified as non-essential", "gold_answer": "SALL4", "gold_category": "depmap", "gold_extraction": {"cell_line": "SCC9_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "SALL4", "cell_line": "SCC9_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2529622523999353}, {"gene_name": "KRTAP4-8", "cell_line": "SCC9_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.075096320796694}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["SALL4", "KRTAP4-8"], "cell_line": "SCC9_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0299", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TTC709_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- LST1: gene effect = -0.277, dependency probability = 0.190 \u2192 classified as non-essential\n- CFHR5: gene effect = -0.117, dependency probability = 0.068 \u2192 classified as non-essential\n- KRT6C: gene effect = 0.045, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "LST1", "gold_category": "depmap", "gold_extraction": {"cell_line": "TTC709_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "LST1", "cell_line": "TTC709_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2765886630835409}, {"gene_name": "CFHR5", "cell_line": "TTC709_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1167855512058903}, {"gene_name": "KRT6C", "cell_line": "TTC709_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.044997090162271}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["LST1", "CFHR5", "KRT6C"], "cell_line": "TTC709_SOFT_TISSUE"}}
+{"question_id": "GEL2-0300", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JVE127_COLON (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PREPL: gene effect = -0.220, dependency probability = 0.135 \u2192 classified as non-essential", "gold_answer": "PREPL", "gold_category": "depmap", "gold_extraction": {"cell_line": "JVE127_COLON", "screen_type": "CRISPR", "genes": [{"gene_name": "PREPL", "cell_line": "JVE127_COLON", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2202904351718274}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PREPL"], "cell_line": "JVE127_COLON"}}
+{"question_id": "GEL2-0301", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KKU213_BILIARY_TRACT (Biliary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CDH16: gene effect = -0.001, dependency probability = 0.019 \u2192 classified as non-essential", "gold_answer": "CDH16", "gold_category": "depmap", "gold_extraction": {"cell_line": "KKU213_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "CDH16", "cell_line": "KKU213_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0007173596939057}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CDH16"], "cell_line": "KKU213_BILIARY_TRACT"}}
+{"question_id": "GEL2-0302", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HO1U1_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PDE7A: gene effect = -0.101, dependency probability = 0.048 \u2192 classified as non-essential\n- OR14C36: gene effect = 0.021, dependency probability = 0.020 \u2192 classified as non-essential", "gold_answer": "PDE7A", "gold_category": "depmap", "gold_extraction": {"cell_line": "HO1U1_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "PDE7A", "cell_line": "HO1U1_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1008562076174134}, {"gene_name": "OR14C36", "cell_line": "HO1U1_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0207605423615127}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PDE7A", "OR14C36"], "cell_line": "HO1U1_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0303", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ELAC2: gene effect = -0.586, dependency probability = 0.790 \u2192 classified as non-essential\n- SNRPB2: gene effect = -0.548, dependency probability = 0.568 \u2192 classified as non-essential", "gold_answer": "ELAC2", "gold_category": "depmap", "gold_extraction": {"cell_line": "JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "ELAC2", "cell_line": "JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.5864890985678011}, {"gene_name": "SNRPB2", "cell_line": "JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.5484336117627059}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ELAC2", "SNRPB2"], "cell_line": "JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0304", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC70_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PALM2AKAP2: gene effect = 0.241, dependency probability = 0.010 \u2192 classified as non-essential\n- TMEM140: gene effect = 0.073, dependency probability = 0.010 \u2192 classified as non-essential\n- MAP3K10: gene effect = -0.021, dependency probability = 0.029 \u2192 classified as non-essential", "gold_answer": "PALM2AKAP2", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC70_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "PALM2AKAP2", "cell_line": "HCC70_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2406803237917413}, {"gene_name": "TMEM140", "cell_line": "HCC70_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0725126622103006}, {"gene_name": "MAP3K10", "cell_line": "HCC70_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0212714323080265}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["PALM2AKAP2", "TMEM140", "MAP3K10"], "cell_line": "HCC70_BREAST"}}
+{"question_id": "GEL2-0305", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in A253_SALIVARY_GLAND (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GRHL2: gene effect = -0.188, dependency probability = 0.110 \u2192 classified as non-essential", "gold_answer": "GRHL2", "gold_category": "depmap", "gold_extraction": {"cell_line": "A253_SALIVARY_GLAND", "screen_type": "CRISPR", "genes": [{"gene_name": "GRHL2", "cell_line": "A253_SALIVARY_GLAND", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1883367428304801}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["GRHL2"], "cell_line": "A253_SALIVARY_GLAND"}}
+{"question_id": "GEL2-0306", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in 127399_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- AMACR: gene effect = 0.259, dependency probability = 0.004 \u2192 classified as non-essential", "gold_answer": "AMACR", "gold_category": "depmap", "gold_extraction": {"cell_line": "127399_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "AMACR", "cell_line": "127399_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.25911833925362}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["AMACR"], "cell_line": "127399_SOFT_TISSUE"}}
+{"question_id": "GEL2-0307", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH1648_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HACD4: gene effect = 0.107, dependency probability = 0.010 \u2192 classified as non-essential\n- BRD3: gene effect = -0.010, dependency probability = 0.018 \u2192 classified as non-essential", "gold_answer": "HACD4", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH1648_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "HACD4", "cell_line": "NCIH1648_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.106815817836723}, {"gene_name": "BRD3", "cell_line": "NCIH1648_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0096108508378467}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["HACD4", "BRD3"], "cell_line": "NCIH1648_LUNG"}}
+{"question_id": "GEL2-0308", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RH4_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PLXNA2: gene effect = -0.041, dependency probability = 0.035 \u2192 classified as non-essential\n- SIRPA: gene effect = 0.076, dependency probability = 0.010 \u2192 classified as non-essential", "gold_answer": "PLXNA2", "gold_category": "depmap", "gold_extraction": {"cell_line": "RH4_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "PLXNA2", "cell_line": "RH4_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0407098850198232}, {"gene_name": "SIRPA", "cell_line": "RH4_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0764503428328645}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PLXNA2", "SIRPA"], "cell_line": "RH4_SOFT_TISSUE"}}
+{"question_id": "GEL2-0309", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in WAOSEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FIZ1: gene effect = 0.365, dependency probability = 0.001 \u2192 classified as non-essential\n- C10orf71: gene effect = -0.009, dependency probability = 0.023 \u2192 classified as non-essential\n- LTA4H: gene effect = -0.108, dependency probability = 0.057 \u2192 classified as non-essential", "gold_answer": "FIZ1", "gold_category": "depmap", "gold_extraction": {"cell_line": "WAOSEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "FIZ1", "cell_line": "WAOSEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.3649766140609886}, {"gene_name": "C10orf71", "cell_line": "WAOSEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0088518836480648}, {"gene_name": "LTA4H", "cell_line": "WAOSEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1080946206827879}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["FIZ1", "C10orf71", "LTA4H"], "cell_line": "WAOSEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0310", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KNS60_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CLEC4D: gene effect = -0.010, dependency probability = 0.025 \u2192 classified as non-essential", "gold_answer": "CLEC4D", "gold_category": "depmap", "gold_extraction": {"cell_line": "KNS60_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "CLEC4D", "cell_line": "KNS60_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0098414795921024}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CLEC4D"], "cell_line": "KNS60_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0311", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC1395_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CCL22: gene effect = 0.024, dependency probability = 0.025 \u2192 classified as non-essential", "gold_answer": "CCL22", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC1395_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "CCL22", "cell_line": "HCC1395_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0240617469174141}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CCL22"], "cell_line": "HCC1395_BREAST"}}
+{"question_id": "GEL2-0312", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KPNSI9S_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KCNH5: gene effect = 0.187, dependency probability = 0.008 \u2192 classified as non-essential\n- SOS2: gene effect = -0.401, dependency probability = 0.249 \u2192 classified as non-essential", "gold_answer": "KCNH5", "gold_category": "depmap", "gold_extraction": {"cell_line": "KPNSI9S_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "KCNH5", "cell_line": "KPNSI9S_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1874801116223914}, {"gene_name": "SOS2", "cell_line": "KPNSI9S_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4006423092069683}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["KCNH5", "SOS2"], "cell_line": "KPNSI9S_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0313", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH841_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF93: gene effect = -0.302, dependency probability = 0.201 \u2192 classified as non-essential\n- RAB27A: gene effect = 0.087, dependency probability = 0.006 \u2192 classified as non-essential", "gold_answer": "ZNF93", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH841_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF93", "cell_line": "NCIH841_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3018186002915656}, {"gene_name": "RAB27A", "cell_line": "NCIH841_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0870315460260008}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ZNF93", "RAB27A"], "cell_line": "NCIH841_LUNG"}}
+{"question_id": "GEL2-0314", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- THEM4: gene effect = -0.299, dependency probability = 0.214 \u2192 classified as non-essential\n- GLIPR1L2: gene effect = 0.113, dependency probability = 0.009 \u2192 classified as non-essential\n- ZNF575: gene effect = 0.024, dependency probability = 0.015 \u2192 classified as non-essential", "gold_answer": "THEM4", "gold_category": "depmap", "gold_extraction": {"cell_line": "RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "THEM4", "cell_line": "RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2992438912332212}, {"gene_name": "GLIPR1L2", "cell_line": "RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1133479712321312}, {"gene_name": "ZNF575", "cell_line": "RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0244120528432927}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["THEM4", "GLIPR1L2", "ZNF575"], "cell_line": "RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0315", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PSS141_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZFP69: gene effect = -0.399, dependency probability = 0.174 \u2192 classified as non-essential", "gold_answer": "ZFP69", "gold_category": "depmap", "gold_extraction": {"cell_line": "PSS141_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "ZFP69", "cell_line": "PSS141_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3985830177045537}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ZFP69"], "cell_line": "PSS141_BONE"}}
+{"question_id": "GEL2-0316", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU2292_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ENOSF1: gene effect = 0.026, dependency probability = 0.016 \u2192 classified as non-essential", "gold_answer": "ENOSF1", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU2292_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "ENOSF1", "cell_line": "SNU2292_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0258212490932852}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ENOSF1"], "cell_line": "SNU2292_LUNG"}}
+{"question_id": "GEL2-0317", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH838_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- BAP1: gene effect = -0.631, dependency probability = 0.834 \u2192 classified as non-essential\n- S100A10: gene effect = 0.018, dependency probability = 0.020 \u2192 classified as non-essential", "gold_answer": "BAP1", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH838_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "BAP1", "cell_line": "NCIH838_LUNG", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.6311394248191029}, {"gene_name": "S100A10", "cell_line": "NCIH838_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0184354205929692}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["BAP1", "S100A10"], "cell_line": "NCIH838_LUNG"}}
+{"question_id": "GEL2-0318", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CCLFPEDS0008T_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DHX57: gene effect = 0.083, dependency probability = 0.009 \u2192 classified as non-essential\n- PRLR: gene effect = 0.027, dependency probability = 0.009 \u2192 classified as non-essential", "gold_answer": "DHX57", "gold_category": "depmap", "gold_extraction": {"cell_line": "CCLFPEDS0008T_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "DHX57", "cell_line": "CCLFPEDS0008T_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0825950258755746}, {"gene_name": "PRLR", "cell_line": "CCLFPEDS0008T_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.02689349383675}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["DHX57", "PRLR"], "cell_line": "CCLFPEDS0008T_SOFT_TISSUE"}}
+{"question_id": "GEL2-0319", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TC32_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- C8orf48: gene effect = 0.032, dependency probability = 0.013 \u2192 classified as non-essential\n- KRTAP4-9: gene effect = -0.187, dependency probability = 0.122 \u2192 classified as non-essential\n- NUDT16: gene effect = 0.047, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "C8orf48", "gold_category": "depmap", "gold_extraction": {"cell_line": "TC32_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "C8orf48", "cell_line": "TC32_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0320497737906927}, {"gene_name": "KRTAP4-9", "cell_line": "TC32_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1871531307310272}, {"gene_name": "NUDT16", "cell_line": "TC32_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0465258599421109}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["C8orf48", "KRTAP4-9", "NUDT16"], "cell_line": "TC32_BONE"}}
+{"question_id": "GEL2-0320", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in LB771HNC_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TALDO1: gene effect = 0.061, dependency probability = 0.019 \u2192 classified as non-essential", "gold_answer": "TALDO1", "gold_category": "depmap", "gold_extraction": {"cell_line": "LB771HNC_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "TALDO1", "cell_line": "LB771HNC_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0605643807253329}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["TALDO1"], "cell_line": "LB771HNC_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0321", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in P4E6_PROSTATE (Prostate) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TM9SF1: gene effect = -0.104, dependency probability = 0.061 \u2192 classified as non-essential", "gold_answer": "TM9SF1", "gold_category": "depmap", "gold_extraction": {"cell_line": "P4E6_PROSTATE", "screen_type": "CRISPR", "genes": [{"gene_name": "TM9SF1", "cell_line": "P4E6_PROSTATE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1035868515220579}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["TM9SF1"], "cell_line": "P4E6_PROSTATE"}}
+{"question_id": "GEL2-0322", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in A2058_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GRID2: gene effect = -0.182, dependency probability = 0.148 \u2192 classified as non-essential\n- DRC12: gene effect = 0.035, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "GRID2", "gold_category": "depmap", "gold_extraction": {"cell_line": "A2058_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "GRID2", "cell_line": "A2058_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.182401117509985}, {"gene_name": "DRC12", "cell_line": "A2058_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0349333555456072}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["GRID2", "DRC12"], "cell_line": "A2058_SKIN"}}
+{"question_id": "GEL2-0323", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC366_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GPR161: gene effect = 0.146, dependency probability = 0.012 \u2192 classified as non-essential\n- OR10C1: gene effect = -0.386, dependency probability = 0.437 \u2192 classified as non-essential", "gold_answer": "GPR161", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC366_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "GPR161", "cell_line": "HCC366_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1460675979836566}, {"gene_name": "OR10C1", "cell_line": "HCC366_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3860477940868089}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["GPR161", "OR10C1"], "cell_line": "HCC366_LUNG"}}
+{"question_id": "GEL2-0324", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SW579_THYROID (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HTATSF1: gene effect = -0.653, dependency probability = 0.810 \u2192 classified as non-essential\n- SGPP2: gene effect = -0.044, dependency probability = 0.021 \u2192 classified as non-essential\n- KRR1: gene effect = -0.572, dependency probability = 0.559 \u2192 classified as non-essential", "gold_answer": "HTATSF1", "gold_category": "depmap", "gold_extraction": {"cell_line": "SW579_THYROID", "screen_type": "CRISPR", "genes": [{"gene_name": "HTATSF1", "cell_line": "SW579_THYROID", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.6526787611701824}, {"gene_name": "SGPP2", "cell_line": "SW579_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0441578457237582}, {"gene_name": "KRR1", "cell_line": "SW579_THYROID", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.572493361336446}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["HTATSF1", "SGPP2", "KRR1"], "cell_line": "SW579_THYROID"}}
+{"question_id": "GEL2-0325", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CA922_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ICA1L: gene effect = 0.011, dependency probability = 0.017 \u2192 classified as non-essential", "gold_answer": "ICA1L", "gold_category": "depmap", "gold_extraction": {"cell_line": "CA922_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "ICA1L", "cell_line": "CA922_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0107214218906612}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ICA1L"], "cell_line": "CA922_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0326", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CAPAN1_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CFHR2: gene effect = 0.145, dependency probability = 0.009 \u2192 classified as non-essential", "gold_answer": "CFHR2", "gold_category": "depmap", "gold_extraction": {"cell_line": "CAPAN1_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "CFHR2", "cell_line": "CAPAN1_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.144601906519442}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CFHR2"], "cell_line": "CAPAN1_PANCREAS"}}
+{"question_id": "GEL2-0327", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in IM95_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CLEC6A: gene effect = -0.004 \u2192 classified as non-essential\n- ITPR1: gene effect = -0.015, dependency probability = 0.019 \u2192 classified as non-essential", "gold_answer": "CLEC6A", "gold_category": "demeter2", "gold_extraction": {"cell_line": "IM95_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "CLEC6A", "cell_line": "IM95_STOMACH", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.00398314220639}, {"gene_name": "ITPR1", "cell_line": "IM95_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.015485712359227}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "demeter2", "gene_symbols": ["CLEC6A", "ITPR1"], "cell_line": "IM95_STOMACH"}}
+{"question_id": "GEL2-0328", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH716_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRR19: gene effect = -0.061, dependency probability = 0.035 \u2192 classified as non-essential\n- ST3GAL1: gene effect = -0.299, dependency probability = 0.238 \u2192 classified as non-essential", "gold_answer": "PRR19", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH716_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "PRR19", "cell_line": "NCIH716_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0607689619178812}, {"gene_name": "ST3GAL1", "cell_line": "NCIH716_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2991161459394864}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PRR19", "ST3GAL1"], "cell_line": "NCIH716_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0329", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TGBC18TKB_LARGE_INTESTINE (Ampulla of Vater) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RRM2B: gene effect = 0.065, dependency probability = 0.012 \u2192 classified as non-essential\n- TMSB4Y: gene effect = 0.294, dependency probability = 0.000 \u2192 classified as non-essential\n- DCAF8L2: gene effect = -0.061, dependency probability = 0.034 \u2192 classified as non-essential", "gold_answer": "RRM2B", "gold_category": "depmap", "gold_extraction": {"cell_line": "TGBC18TKB_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "RRM2B", "cell_line": "TGBC18TKB_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0647839977265872}, {"gene_name": "TMSB4Y", "cell_line": "TGBC18TKB_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2938508508563858}, {"gene_name": "DCAF8L2", "cell_line": "TGBC18TKB_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0613787131217611}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["RRM2B", "TMSB4Y", "DCAF8L2"], "cell_line": "TGBC18TKB_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0330", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNB75_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- LHX4: gene effect = -0.110, dependency probability = 0.059 \u2192 classified as non-essential", "gold_answer": "LHX4", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNB75_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "LHX4", "cell_line": "SNB75_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1099740940174036}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["LHX4"], "cell_line": "SNB75_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0331", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JHOS2_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GPA33: gene effect = -0.123, dependency probability = 0.074 \u2192 classified as non-essential", "gold_answer": "GPA33", "gold_category": "depmap", "gold_extraction": {"cell_line": "JHOS2_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "GPA33", "cell_line": "JHOS2_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1229262872766656}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["GPA33"], "cell_line": "JHOS2_OVARY"}}
+{"question_id": "GEL2-0332", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in COV413A_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CDH10: gene effect = 0.199, dependency probability = 0.002 \u2192 classified as non-essential\n- SLC38A2: gene effect = -0.333, dependency probability = 0.200 \u2192 classified as non-essential", "gold_answer": "CDH10", "gold_category": "depmap", "gold_extraction": {"cell_line": "COV413A_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "CDH10", "cell_line": "COV413A_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1992924580411436}, {"gene_name": "SLC38A2", "cell_line": "COV413A_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3332540009226366}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CDH10", "SLC38A2"], "cell_line": "COV413A_OVARY"}}
+{"question_id": "GEL2-0333", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KATOIII_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HSPB6: gene effect = -0.127, dependency probability = 0.081 \u2192 classified as non-essential\n- RNF34: gene effect = -0.042, dependency probability = 0.025 \u2192 classified as non-essential", "gold_answer": "HSPB6", "gold_category": "depmap", "gold_extraction": {"cell_line": "KATOIII_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "HSPB6", "cell_line": "KATOIII_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1272271246668171}, {"gene_name": "RNF34", "cell_line": "KATOIII_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0420690602824113}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["HSPB6", "RNF34"], "cell_line": "KATOIII_STOMACH"}}
+{"question_id": "GEL2-0334", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MM127_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NSMCE1: gene effect = -0.009, dependency probability = 0.026 \u2192 classified as non-essential\n- CELF6: gene effect = 0.279, dependency probability = 0.000 \u2192 classified as non-essential\n- C11orf16: gene effect = 0.029, dependency probability = 0.014 \u2192 classified as non-essential", "gold_answer": "NSMCE1", "gold_category": "depmap", "gold_extraction": {"cell_line": "MM127_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "NSMCE1", "cell_line": "MM127_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0092953963311154}, {"gene_name": "CELF6", "cell_line": "MM127_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2794133481172247}, {"gene_name": "C11orf16", "cell_line": "MM127_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0292567489997289}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["NSMCE1", "CELF6", "C11orf16"], "cell_line": "MM127_SKIN"}}
+{"question_id": "GEL2-0335", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SSP25_BILIARY_TRACT (Biliary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MEIKIN: gene effect = 0.019, dependency probability = 0.019 \u2192 classified as non-essential", "gold_answer": "MEIKIN", "gold_category": "depmap", "gold_extraction": {"cell_line": "SSP25_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "MEIKIN", "cell_line": "SSP25_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0194752489338279}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MEIKIN"], "cell_line": "SSP25_BILIARY_TRACT"}}
+{"question_id": "GEL2-0336", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HS729_SOFT_TISSUE (Fibroblast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GUCY2F: gene effect = 0.131, dependency probability = 0.007 \u2192 classified as non-essential", "gold_answer": "GUCY2F", "gold_category": "depmap", "gold_extraction": {"cell_line": "HS729_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "GUCY2F", "cell_line": "HS729_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1313324891836159}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["GUCY2F"], "cell_line": "HS729_SOFT_TISSUE"}}
+{"question_id": "GEL2-0337", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC515_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PHLPP2: gene effect = 0.199, dependency probability = 0.004 \u2192 classified as non-essential\n- MIF4GD: gene effect = 0.113, dependency probability = 0.009 \u2192 classified as non-essential", "gold_answer": "PHLPP2", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC515_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "PHLPP2", "cell_line": "HCC515_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1993162345668414}, {"gene_name": "MIF4GD", "cell_line": "HCC515_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1132298212069776}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PHLPP2", "MIF4GD"], "cell_line": "HCC515_LUNG"}}
+{"question_id": "GEL2-0338", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MS751_CERVIX (Cervix) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CCNB2: gene effect = -0.038, dependency probability = 0.043 \u2192 classified as non-essential\n- MTSS1: gene effect = -0.007, dependency probability = 0.023 \u2192 classified as non-essential", "gold_answer": "CCNB2", "gold_category": "depmap", "gold_extraction": {"cell_line": "MS751_CERVIX", "screen_type": "CRISPR", "genes": [{"gene_name": "CCNB2", "cell_line": "MS751_CERVIX", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0382608554762579}, {"gene_name": "MTSS1", "cell_line": "MS751_CERVIX", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0066735337940677}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CCNB2", "MTSS1"], "cell_line": "MS751_CERVIX"}}
+{"question_id": "GEL2-0339", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JHH7_LIVER (Liver) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SEC14L3: gene effect = 0.068, dependency probability = 0.008 \u2192 classified as non-essential\n- FAM209B: gene effect = -0.176, dependency probability = 0.087 \u2192 classified as non-essential\n- TMC1: gene effect = 0.215, dependency probability = 0.003 \u2192 classified as non-essential", "gold_answer": "SEC14L3", "gold_category": "depmap", "gold_extraction": {"cell_line": "JHH7_LIVER", "screen_type": "CRISPR", "genes": [{"gene_name": "SEC14L3", "cell_line": "JHH7_LIVER", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0683381140809253}, {"gene_name": "FAM209B", "cell_line": "JHH7_LIVER", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1757285390213865}, {"gene_name": "TMC1", "cell_line": "JHH7_LIVER", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2147937267197373}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["SEC14L3", "FAM209B", "TMC1"], "cell_line": "JHH7_LIVER"}}
+{"question_id": "GEL2-0340", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in A673_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SLC25A42: gene effect = -0.398, dependency probability = 0.320 \u2192 classified as non-essential", "gold_answer": "SLC25A42", "gold_category": "depmap", "gold_extraction": {"cell_line": "A673_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "SLC25A42", "cell_line": "A673_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3984350860198004}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SLC25A42"], "cell_line": "A673_BONE"}}
+{"question_id": "GEL2-0341", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PACADD135_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PPM1B: gene effect = 0.058, dependency probability = 0.016 \u2192 classified as non-essential", "gold_answer": "PPM1B", "gold_category": "depmap", "gold_extraction": {"cell_line": "PACADD135_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "PPM1B", "cell_line": "PACADD135_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0578943645150125}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PPM1B"], "cell_line": "PACADD135_PANCREAS"}}
+{"question_id": "GEL2-0342", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCCIT_TESTIS (Testis) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PITPNA: gene effect = 0.045, dependency probability = 0.013 \u2192 classified as non-essential\n- GAK: gene effect = -0.224, dependency probability = 0.101 \u2192 classified as non-essential", "gold_answer": "PITPNA", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCCIT_TESTIS", "screen_type": "CRISPR", "genes": [{"gene_name": "PITPNA", "cell_line": "NCCIT_TESTIS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0449614725231737}, {"gene_name": "GAK", "cell_line": "NCCIT_TESTIS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.224151006911169}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PITPNA", "GAK"], "cell_line": "NCCIT_TESTIS"}}
+{"question_id": "GEL2-0343", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in Y79_AUTONOMIC_GANGLIA (Eye) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PRDX2: gene effect = -0.331, dependency probability = 0.264 \u2192 classified as non-essential\n- EVC: gene effect = 0.112, dependency probability = 0.004 \u2192 classified as non-essential", "gold_answer": "PRDX2", "gold_category": "depmap", "gold_extraction": {"cell_line": "Y79_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "PRDX2", "cell_line": "Y79_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3305322301649991}, {"gene_name": "EVC", "cell_line": "Y79_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1115137878179697}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PRDX2", "EVC"], "cell_line": "Y79_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0344", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCE4_OESOPHAGUS (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ACAT1: gene effect = 0.185, dependency probability = 0.007 \u2192 classified as non-essential\n- PLA2G4F: gene effect = -0.052, dependency probability = 0.027 \u2192 classified as non-essential\n- MEPCE: gene effect = -0.734, dependency probability = 0.799 \u2192 classified as non-essential", "gold_answer": "ACAT1", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCE4_OESOPHAGUS", "screen_type": "CRISPR", "genes": [{"gene_name": "ACAT1", "cell_line": "HCE4_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1854374520749093}, {"gene_name": "PLA2G4F", "cell_line": "HCE4_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0523817353084002}, {"gene_name": "MEPCE", "cell_line": "HCE4_OESOPHAGUS", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.7336479499034527}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["ACAT1", "PLA2G4F", "MEPCE"], "cell_line": "HCE4_OESOPHAGUS"}}
+{"question_id": "GEL2-0345", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NOS1_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MEGF9: gene effect = -0.054, dependency probability = 0.029 \u2192 classified as non-essential", "gold_answer": "MEGF9", "gold_category": "depmap", "gold_extraction": {"cell_line": "NOS1_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "MEGF9", "cell_line": "NOS1_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0536948682874856}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MEGF9"], "cell_line": "NOS1_BONE"}}
+{"question_id": "GEL2-0346", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU886_LIVER (Liver) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- BICDL2: gene effect = -0.266, dependency probability = 0.182 \u2192 classified as non-essential", "gold_answer": "BICDL2", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU886_LIVER", "screen_type": "CRISPR", "genes": [{"gene_name": "BICDL2", "cell_line": "SNU886_LIVER", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2660739916364598}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["BICDL2"], "cell_line": "SNU886_LIVER"}}
+{"question_id": "GEL2-0347", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HSC39_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ATP6V0E2: gene effect = -0.114, dependency probability = 0.068 \u2192 classified as non-essential\n- FBXO9: gene effect = -0.122, dependency probability = 0.082 \u2192 classified as non-essential", "gold_answer": "ATP6V0E2", "gold_category": "depmap", "gold_extraction": {"cell_line": "HSC39_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "ATP6V0E2", "cell_line": "HSC39_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1135915370988085}, {"gene_name": "FBXO9", "cell_line": "HSC39_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1220144443414353}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ATP6V0E2", "FBXO9"], "cell_line": "HSC39_STOMACH"}}
+{"question_id": "GEL2-0348", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TANGO2: gene effect = 0.034, dependency probability = 0.013 \u2192 classified as non-essential\n- ZNF587: gene effect = -0.601, dependency probability = 0.703 \u2192 classified as non-essential", "gold_answer": "TANGO2", "gold_category": "depmap", "gold_extraction": {"cell_line": "MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "TANGO2", "cell_line": "MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0335500720666526}, {"gene_name": "ZNF587", "cell_line": "MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.6013030145735379}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["TANGO2", "ZNF587"], "cell_line": "MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0349", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in GB2_BILIARY_TRACT (Biliary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RHPN1: gene effect = -0.217, dependency probability = 0.182 \u2192 classified as non-essential\n- HNRNPD: gene effect = -0.314, dependency probability = 0.228 \u2192 classified as non-essential\n- OR10D3: gene effect = -0.096, dependency probability = 0.040 \u2192 classified as non-essential", "gold_answer": "RHPN1", "gold_category": "depmap", "gold_extraction": {"cell_line": "GB2_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "RHPN1", "cell_line": "GB2_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2169140237081973}, {"gene_name": "HNRNPD", "cell_line": "GB2_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3135022693093657}, {"gene_name": "OR10D3", "cell_line": "GB2_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0957988631221498}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["RHPN1", "HNRNPD", "OR10D3"], "cell_line": "GB2_BILIARY_TRACT"}}
+{"question_id": "GEL2-0350", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNUC1_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ADAMTS8: gene effect = -0.174, dependency probability = 0.083 \u2192 classified as non-essential", "gold_answer": "ADAMTS8", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNUC1_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "ADAMTS8", "cell_line": "SNUC1_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1735142679250354}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ADAMTS8"], "cell_line": "SNUC1_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0351", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HEC59_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ICAM3: gene effect = -0.096, dependency probability = 0.049 \u2192 classified as non-essential", "gold_answer": "ICAM3", "gold_category": "depmap", "gold_extraction": {"cell_line": "HEC59_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "ICAM3", "cell_line": "HEC59_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0964628663845058}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ICAM3"], "cell_line": "HEC59_ENDOMETRIUM"}}
+{"question_id": "GEL2-0352", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KP363T_COLON (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- OR5D14: gene effect = 0.155, dependency probability = 0.004 \u2192 classified as non-essential\n- MCUB: gene effect = 0.296, dependency probability = 0.000 \u2192 classified as non-essential", "gold_answer": "OR5D14", "gold_category": "depmap", "gold_extraction": {"cell_line": "KP363T_COLON", "screen_type": "CRISPR", "genes": [{"gene_name": "OR5D14", "cell_line": "KP363T_COLON", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.155132124699512}, {"gene_name": "MCUB", "cell_line": "KP363T_COLON", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2955638341019641}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["OR5D14", "MCUB"], "cell_line": "KP363T_COLON"}}
+{"question_id": "GEL2-0353", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in BB30HNC_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- S1PR2: gene effect = 0.126, dependency probability = 0.007 \u2192 classified as non-essential\n- TAPT1: gene effect = -0.240, dependency probability = 0.157 \u2192 classified as non-essential", "gold_answer": "S1PR2", "gold_category": "depmap", "gold_extraction": {"cell_line": "BB30HNC_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "S1PR2", "cell_line": "BB30HNC_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1259990680198277}, {"gene_name": "TAPT1", "cell_line": "BB30HNC_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2402178888312052}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["S1PR2", "TAPT1"], "cell_line": "BB30HNC_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0354", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SKMEL19_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SH3PXD2A: gene effect = 0.070, dependency probability = 0.008 \u2192 classified as non-essential\n- PGBD5: gene effect = 0.460, dependency probability = 0.000 \u2192 classified as non-essential\n- UGT1A4: gene effect = -0.055, dependency probability = 0.036 \u2192 classified as non-essential", "gold_answer": "SH3PXD2A", "gold_category": "depmap", "gold_extraction": {"cell_line": "SKMEL19_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "SH3PXD2A", "cell_line": "SKMEL19_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0701280485568881}, {"gene_name": "PGBD5", "cell_line": "SKMEL19_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.4602930020423024}, {"gene_name": "UGT1A4", "cell_line": "SKMEL19_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0547882631074421}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["SH3PXD2A", "PGBD5", "UGT1A4"], "cell_line": "SKMEL19_SKIN"}}
+{"question_id": "GEL2-0355", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MM473_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CLIP4: gene effect = 0.098, dependency probability = 0.004 \u2192 classified as non-essential", "gold_answer": "CLIP4", "gold_category": "depmap", "gold_extraction": {"cell_line": "MM473_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "CLIP4", "cell_line": "MM473_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0984413196589202}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CLIP4"], "cell_line": "MM473_SKIN"}}
+{"question_id": "GEL2-0356", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in ZR751_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ANAPC13: gene effect = -0.224, dependency probability = 0.148 \u2192 classified as non-essential", "gold_answer": "ANAPC13", "gold_category": "depmap", "gold_extraction": {"cell_line": "ZR751_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "ANAPC13", "cell_line": "ZR751_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.223982264588059}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ANAPC13"], "cell_line": "ZR751_BREAST"}}
+{"question_id": "GEL2-0357", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PATU8988T_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SERINC5: gene effect = 0.101, dependency probability = 0.010 \u2192 classified as non-essential\n- ELK1: gene effect = -0.010, dependency probability = 0.026 \u2192 classified as non-essential", "gold_answer": "SERINC5", "gold_category": "depmap", "gold_extraction": {"cell_line": "PATU8988T_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "SERINC5", "cell_line": "PATU8988T_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1010611630352738}, {"gene_name": "ELK1", "cell_line": "PATU8988T_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0096083407490184}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["SERINC5", "ELK1"], "cell_line": "PATU8988T_PANCREAS"}}
+{"question_id": "GEL2-0358", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PCI38_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ISG20L2: gene effect = -0.381, dependency probability = 0.406 \u2192 classified as non-essential\n- CHIT1: gene effect = -0.068, dependency probability = 0.025 \u2192 classified as non-essential", "gold_answer": "ISG20L2", "gold_category": "depmap", "gold_extraction": {"cell_line": "PCI38_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "ISG20L2", "cell_line": "PCI38_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3806184649578525}, {"gene_name": "CHIT1", "cell_line": "PCI38_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0676473153359039}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ISG20L2", "CHIT1"], "cell_line": "PCI38_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0359", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HA1E_KIDNEY (Kidney) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PSG9: gene effect = -0.004, dependency probability = 0.020 \u2192 classified as non-essential\n- GXYLT2: gene effect = 0.098, dependency probability = 0.005 \u2192 classified as non-essential\n- PSMC4: gene effect = -0.160, dependency probability = 0.072 \u2192 classified as non-essential", "gold_answer": "PSG9", "gold_category": "depmap", "gold_extraction": {"cell_line": "HA1E_KIDNEY", "screen_type": "CRISPR", "genes": [{"gene_name": "PSG9", "cell_line": "HA1E_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0036671603628155}, {"gene_name": "GXYLT2", "cell_line": "HA1E_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0977312002153915}, {"gene_name": "PSMC4", "cell_line": "HA1E_KIDNEY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1597356283767332}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["PSG9", "GXYLT2", "PSMC4"], "cell_line": "HA1E_KIDNEY"}}
+{"question_id": "GEL2-0360", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HEC50B_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF776: gene effect = 0.124, dependency probability = 0.003 \u2192 classified as non-essential", "gold_answer": "ZNF776", "gold_category": "depmap", "gold_extraction": {"cell_line": "HEC50B_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF776", "cell_line": "HEC50B_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1240440460539081}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ZNF776"], "cell_line": "HEC50B_ENDOMETRIUM"}}
+{"question_id": "GEL2-0361", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in EGI1_BILIARY_TRACT (Biliary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- OXTR: gene effect = 0.043, dependency probability = 0.014 \u2192 classified as non-essential", "gold_answer": "OXTR", "gold_category": "depmap", "gold_extraction": {"cell_line": "EGI1_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "OXTR", "cell_line": "EGI1_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0427952100670223}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["OXTR"], "cell_line": "EGI1_BILIARY_TRACT"}}
+{"question_id": "GEL2-0362", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC56_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HTRA3: gene effect = -0.070, dependency probability = 0.031 \u2192 classified as non-essential\n- SKP2: gene effect = -0.120, dependency probability = 0.055 \u2192 classified as non-essential", "gold_answer": "HTRA3", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC56_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "HTRA3", "cell_line": "HCC56_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0700489571261162}, {"gene_name": "SKP2", "cell_line": "HCC56_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1203633713904127}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["HTRA3", "SKP2"], "cell_line": "HCC56_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0363", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SHMAC5_PROSTATE (Prostate) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PARP15: gene effect = -0.174, dependency probability = 0.065 \u2192 classified as non-essential\n- TATDN2: gene effect = -0.104, dependency probability = 0.033 \u2192 classified as non-essential", "gold_answer": "PARP15", "gold_category": "depmap", "gold_extraction": {"cell_line": "SHMAC5_PROSTATE", "screen_type": "CRISPR", "genes": [{"gene_name": "PARP15", "cell_line": "SHMAC5_PROSTATE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1736974877582563}, {"gene_name": "TATDN2", "cell_line": "SHMAC5_PROSTATE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1042504545427386}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PARP15", "TATDN2"], "cell_line": "SHMAC5_PROSTATE"}}
+{"question_id": "GEL2-0364", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SCH_STOMACH (Other) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GALK1: gene effect = -0.201, dependency probability = 0.091 \u2192 classified as non-essential\n- GTDC1: gene effect = 0.220, dependency probability = 0.002 \u2192 classified as non-essential\n- CD200R1L: gene effect = -0.041, dependency probability = 0.029 \u2192 classified as non-essential", "gold_answer": "GALK1", "gold_category": "depmap", "gold_extraction": {"cell_line": "SCH_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "GALK1", "cell_line": "SCH_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2009878428294698}, {"gene_name": "GTDC1", "cell_line": "SCH_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2200955990924757}, {"gene_name": "CD200R1L", "cell_line": "SCH_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0406355503378645}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["GALK1", "GTDC1", "CD200R1L"], "cell_line": "SCH_STOMACH"}}
+{"question_id": "GEL2-0365", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CCC5_BILIARY_TRACT (Biliary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF493: gene effect = 0.203, dependency probability = 0.004 \u2192 classified as non-essential", "gold_answer": "ZNF493", "gold_category": "depmap", "gold_extraction": {"cell_line": "CCC5_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF493", "cell_line": "CCC5_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2028579837266713}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ZNF493"], "cell_line": "CCC5_BILIARY_TRACT"}}
+{"question_id": "GEL2-0366", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in LN229_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MAP3K12: gene effect = -0.166, dependency probability = 0.131 \u2192 classified as non-essential", "gold_answer": "MAP3K12", "gold_category": "depmap", "gold_extraction": {"cell_line": "LN229_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "MAP3K12", "cell_line": "LN229_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1658627557289247}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MAP3K12"], "cell_line": "LN229_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0367", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in T3M4_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RGS6: gene effect = -0.137, dependency probability = 0.056 \u2192 classified as non-essential\n- PCDHGA1: gene effect = -0.168, dependency probability = 0.109 \u2192 classified as non-essential", "gold_answer": "RGS6", "gold_category": "depmap", "gold_extraction": {"cell_line": "T3M4_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "RGS6", "cell_line": "T3M4_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1366821194348104}, {"gene_name": "PCDHGA1", "cell_line": "T3M4_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1678355583352489}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["RGS6", "PCDHGA1"], "cell_line": "T3M4_PANCREAS"}}
+{"question_id": "GEL2-0368", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TN2_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF154: gene effect = 0.183, dependency probability = 0.004 \u2192 classified as non-essential\n- UBAP2L: gene effect = -0.067, dependency probability = 0.050 \u2192 classified as non-essential", "gold_answer": "ZNF154", "gold_category": "depmap", "gold_extraction": {"cell_line": "TN2_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF154", "cell_line": "TN2_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1828757877102618}, {"gene_name": "UBAP2L", "cell_line": "TN2_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0665958855132234}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ZNF154", "UBAP2L"], "cell_line": "TN2_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0369", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in LOUNH91_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CABYR: gene effect = 0.077, dependency probability = 0.021 \u2192 classified as non-essential\n- NOBOX: gene effect = -0.079, dependency probability = 0.042 \u2192 classified as non-essential\n- IL21R: gene effect = 0.066, dependency probability = 0.006 \u2192 classified as non-essential", "gold_answer": "CABYR", "gold_category": "depmap", "gold_extraction": {"cell_line": "LOUNH91_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "CABYR", "cell_line": "LOUNH91_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0768981146653999}, {"gene_name": "NOBOX", "cell_line": "LOUNH91_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.078998848835359}, {"gene_name": "IL21R", "cell_line": "LOUNH91_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0661658754776582}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["CABYR", "NOBOX", "IL21R"], "cell_line": "LOUNH91_LUNG"}}
+{"question_id": "GEL2-0370", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH1155_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RSRC2: gene effect = -0.221, dependency probability = 0.176 \u2192 classified as non-essential", "gold_answer": "RSRC2", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH1155_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "RSRC2", "cell_line": "NCIH1155_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2207227879905282}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["RSRC2"], "cell_line": "NCIH1155_LUNG"}}
+{"question_id": "GEL2-0371", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU308_BILIARY_TRACT (Biliary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MTERF4: gene effect = -0.160, dependency probability = 0.087 \u2192 classified as non-essential", "gold_answer": "MTERF4", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU308_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "MTERF4", "cell_line": "SNU308_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1596804925124898}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MTERF4"], "cell_line": "SNU308_BILIARY_TRACT"}}
+{"question_id": "GEL2-0372", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NZM7_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MYO1H: gene effect = -0.174, dependency probability = 0.146 \u2192 classified as non-essential\n- IGF1R: gene effect = -0.419, dependency probability = 0.346 \u2192 classified as non-essential", "gold_answer": "MYO1H", "gold_category": "depmap", "gold_extraction": {"cell_line": "NZM7_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "MYO1H", "cell_line": "NZM7_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1744660527796266}, {"gene_name": "IGF1R", "cell_line": "NZM7_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4188215707882778}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["MYO1H", "IGF1R"], "cell_line": "NZM7_SKIN"}}
+{"question_id": "GEL2-0373", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HHUA_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TSPAN17: gene effect = 0.067, dependency probability = 0.007 \u2192 classified as non-essential\n- THYN1: gene effect = 0.005, dependency probability = 0.018 \u2192 classified as non-essential", "gold_answer": "TSPAN17", "gold_category": "depmap", "gold_extraction": {"cell_line": "HHUA_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "TSPAN17", "cell_line": "HHUA_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0667912512618206}, {"gene_name": "THYN1", "cell_line": "HHUA_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0051852870725381}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["TSPAN17", "THYN1"], "cell_line": "HHUA_ENDOMETRIUM"}}
+{"question_id": "GEL2-0374", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU251_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NUDT9: gene effect = 0.126, dependency probability = 0.005 \u2192 classified as non-essential\n- PARP6: gene effect = 0.139, dependency probability = 0.007 \u2192 classified as non-essential\n- DPH1: gene effect = 0.182, dependency probability = 0.009 \u2192 classified as non-essential", "gold_answer": "NUDT9", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU251_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "NUDT9", "cell_line": "SNU251_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1257796908989291}, {"gene_name": "PARP6", "cell_line": "SNU251_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1394560744822015}, {"gene_name": "DPH1", "cell_line": "SNU251_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1815117845267854}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["NUDT9", "PARP6", "DPH1"], "cell_line": "SNU251_OVARY"}}
+{"question_id": "GEL2-0375", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SUDHL5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- APOC4: gene effect = 0.027, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "APOC4", "gold_category": "depmap", "gold_extraction": {"cell_line": "SUDHL5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "APOC4", "cell_line": "SUDHL5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0270912196245924}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["APOC4"], "cell_line": "SUDHL5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0376", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HEYA8_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- POLR2K: gene effect = -0.748, dependency probability = 0.894 \u2192 classified as non-essential", "gold_answer": "POLR2K", "gold_category": "depmap", "gold_extraction": {"cell_line": "HEYA8_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "POLR2K", "cell_line": "HEYA8_OVARY", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.7478357454950493}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["POLR2K"], "cell_line": "HEYA8_OVARY"}}
+{"question_id": "GEL2-0377", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCA1_CERVIX (Cervix) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- UCHL3: gene effect = 0.065, dependency probability = 0.018 \u2192 classified as non-essential\n- KRTAP4-11: gene effect = -0.392, dependency probability = 0.406 \u2192 classified as non-essential", "gold_answer": "UCHL3", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCA1_CERVIX", "screen_type": "CRISPR", "genes": [{"gene_name": "UCHL3", "cell_line": "HCA1_CERVIX", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0647022910100587}, {"gene_name": "KRTAP4-11", "cell_line": "HCA1_CERVIX", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3916661184480563}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["UCHL3", "KRTAP4-11"], "cell_line": "HCA1_CERVIX"}}
+{"question_id": "GEL2-0378", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JHUEM7_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NOX1: gene effect = -0.044, dependency probability = 0.033 \u2192 classified as non-essential\n- BRMS1: gene effect = -0.337, dependency probability = 0.371 \u2192 classified as non-essential", "gold_answer": "NOX1", "gold_category": "depmap", "gold_extraction": {"cell_line": "JHUEM7_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "NOX1", "cell_line": "JHUEM7_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0442022081075485}, {"gene_name": "BRMS1", "cell_line": "JHUEM7_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3374580739422493}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["NOX1", "BRMS1"], "cell_line": "JHUEM7_ENDOMETRIUM"}}
+{"question_id": "GEL2-0379", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SMZ1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GNAT2: gene effect = -0.018, dependency probability = 0.021 \u2192 classified as non-essential\n- WASL: gene effect = -0.276, dependency probability = 0.273 \u2192 classified as non-essential\n- TMEFF2: gene effect = -0.079, dependency probability = 0.045 \u2192 classified as non-essential", "gold_answer": "GNAT2", "gold_category": "depmap", "gold_extraction": {"cell_line": "SMZ1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "GNAT2", "cell_line": "SMZ1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0180490528205337}, {"gene_name": "WASL", "cell_line": "SMZ1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2756607692918761}, {"gene_name": "TMEFF2", "cell_line": "SMZ1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0790780281051085}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["GNAT2", "WASL", "TMEFF2"], "cell_line": "SMZ1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0380", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH2030_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KHDC3L: gene effect = 0.281 \u2192 classified as non-essential", "gold_answer": "KHDC3L", "gold_category": "demeter2", "gold_extraction": {"cell_line": "NCIH2030_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "KHDC3L", "cell_line": "NCIH2030_LUNG", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": 0.280643937283}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "demeter2", "gene_symbols": ["KHDC3L"], "cell_line": "NCIH2030_LUNG"}}
+{"question_id": "GEL2-0381", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH2126_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- LPIN3: gene effect = 0.211, dependency probability = 0.007 \u2192 classified as non-essential", "gold_answer": "LPIN3", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH2126_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "LPIN3", "cell_line": "NCIH2126_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2106283495627463}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["LPIN3"], "cell_line": "NCIH2126_LUNG"}}
+{"question_id": "GEL2-0382", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TM31_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- LRG1: gene effect = 0.062, dependency probability = 0.016 \u2192 classified as non-essential\n- TARS1: gene effect = -0.666, dependency probability = 0.771 \u2192 classified as non-essential", "gold_answer": "LRG1", "gold_category": "depmap", "gold_extraction": {"cell_line": "TM31_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "LRG1", "cell_line": "TM31_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0624241211100917}, {"gene_name": "TARS1", "cell_line": "TM31_CENTRAL_NERVOUS_SYSTEM", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.6659306763601684}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["LRG1", "TARS1"], "cell_line": "TM31_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0383", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH1915_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GPR55: gene effect = 0.140, dependency probability = 0.008 \u2192 classified as non-essential\n- CEP152: gene effect = -0.253, dependency probability = 0.231 \u2192 classified as non-essential", "gold_answer": "GPR55", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH1915_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "GPR55", "cell_line": "NCIH1915_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1400256927790962}, {"gene_name": "CEP152", "cell_line": "NCIH1915_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2527020183315036}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["GPR55", "CEP152"], "cell_line": "NCIH1915_LUNG"}}
+{"question_id": "GEL2-0384", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CLUAP1: gene effect = -0.122, dependency probability = 0.048 \u2192 classified as non-essential\n- LRWD1: gene effect = 0.018, dependency probability = 0.013 \u2192 classified as non-essential\n- SIK3: gene effect = 0.126, dependency probability = 0.005 \u2192 classified as non-essential", "gold_answer": "CLUAP1", "gold_category": "depmap", "gold_extraction": {"cell_line": "HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "CLUAP1", "cell_line": "HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1216950731634078}, {"gene_name": "LRWD1", "cell_line": "HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0179039953593358}, {"gene_name": "SIK3", "cell_line": "HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1260010383058201}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["CLUAP1", "LRWD1", "SIK3"], "cell_line": "HUNS1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0385", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in ICC2_BILIARY_TRACT (Biliary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- LEFTY1: gene effect = 0.208, dependency probability = 0.005 \u2192 classified as non-essential", "gold_answer": "LEFTY1", "gold_category": "depmap", "gold_extraction": {"cell_line": "ICC2_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "LEFTY1", "cell_line": "ICC2_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2076123892975166}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["LEFTY1"], "cell_line": "ICC2_BILIARY_TRACT"}}
+{"question_id": "GEL2-0386", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MERO14_PLEURA (Pleura) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CRYGN: gene effect = -0.189, dependency probability = 0.077 \u2192 classified as non-essential", "gold_answer": "CRYGN", "gold_category": "depmap", "gold_extraction": {"cell_line": "MERO14_PLEURA", "screen_type": "CRISPR", "genes": [{"gene_name": "CRYGN", "cell_line": "MERO14_PLEURA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1885417963499929}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CRYGN"], "cell_line": "MERO14_PLEURA"}}
+{"question_id": "GEL2-0387", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PANC1005_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SOCS4: gene effect = -0.121, dependency probability = 0.072 \u2192 classified as non-essential\n- TMEM205: gene effect = -0.124, dependency probability = 0.073 \u2192 classified as non-essential", "gold_answer": "SOCS4", "gold_category": "depmap", "gold_extraction": {"cell_line": "PANC1005_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "SOCS4", "cell_line": "PANC1005_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1205140052877066}, {"gene_name": "TMEM205", "cell_line": "PANC1005_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1244815230630214}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["SOCS4", "TMEM205"], "cell_line": "PANC1005_PANCREAS"}}
+{"question_id": "GEL2-0388", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SW48_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TAS2R9: gene effect = 0.209, dependency probability = 0.002 \u2192 classified as non-essential\n- FIGNL1: gene effect = 0.027, dependency probability = 0.017 \u2192 classified as non-essential", "gold_answer": "TAS2R9", "gold_category": "depmap", "gold_extraction": {"cell_line": "SW48_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "TAS2R9", "cell_line": "SW48_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2089509179471993}, {"gene_name": "FIGNL1", "cell_line": "SW48_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0274676313623421}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["TAS2R9", "FIGNL1"], "cell_line": "SW48_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0389", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OCIP5X_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TRAK1: gene effect = -0.047, dependency probability = 0.026 \u2192 classified as non-essential\n- C11orf71: gene effect = 0.002, dependency probability = 0.020 \u2192 classified as non-essential\n- ZNF646: gene effect = -0.067, dependency probability = 0.025 \u2192 classified as non-essential", "gold_answer": "TRAK1", "gold_category": "depmap", "gold_extraction": {"cell_line": "OCIP5X_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "TRAK1", "cell_line": "OCIP5X_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0474835075900301}, {"gene_name": "C11orf71", "cell_line": "OCIP5X_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0023579393338274}, {"gene_name": "ZNF646", "cell_line": "OCIP5X_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0671954499833346}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["TRAK1", "C11orf71", "ZNF646"], "cell_line": "OCIP5X_OVARY"}}
+{"question_id": "GEL2-0390", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HEC1_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CAMK2N1: gene effect = 0.020, dependency probability = 0.030 \u2192 classified as non-essential", "gold_answer": "CAMK2N1", "gold_category": "depmap", "gold_extraction": {"cell_line": "HEC1_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "CAMK2N1", "cell_line": "HEC1_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0203227284032979}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CAMK2N1"], "cell_line": "HEC1_ENDOMETRIUM"}}
+{"question_id": "GEL2-0391", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC827_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- AGFG1: gene effect = -0.035, dependency probability = 0.028 \u2192 classified as non-essential", "gold_answer": "AGFG1", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC827_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "AGFG1", "cell_line": "HCC827_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0345428237817582}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["AGFG1"], "cell_line": "HCC827_LUNG"}}
+{"question_id": "GEL2-0392", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MERO83_PLEURA (Pleura) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ABCC3: gene effect = -0.186, dependency probability = 0.114 \u2192 classified as non-essential\n- E4F1: gene effect = -0.713, dependency probability = 0.915 \u2192 classified as non-essential", "gold_answer": "ABCC3", "gold_category": "depmap", "gold_extraction": {"cell_line": "MERO83_PLEURA", "screen_type": "CRISPR", "genes": [{"gene_name": "ABCC3", "cell_line": "MERO83_PLEURA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.186398394149033}, {"gene_name": "E4F1", "cell_line": "MERO83_PLEURA", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.713049575068359}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ABCC3", "E4F1"], "cell_line": "MERO83_PLEURA"}}
+{"question_id": "GEL2-0393", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NMB_AUTONOMIC_GANGLIA (Peripheral Nervous System) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NIN: gene effect = -0.102, dependency probability = 0.043 \u2192 classified as non-essential\n- SPACA1: gene effect = 0.263 \u2192 classified as non-essential", "gold_answer": "NIN", "gold_category": "depmap", "gold_extraction": {"cell_line": "NMB_AUTONOMIC_GANGLIA", "screen_type": "CRISPR", "genes": [{"gene_name": "NIN", "cell_line": "NMB_AUTONOMIC_GANGLIA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1015711204121844}, {"gene_name": "SPACA1", "cell_line": "NMB_AUTONOMIC_GANGLIA", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": 0.263305700808}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["NIN", "SPACA1"], "cell_line": "NMB_AUTONOMIC_GANGLIA"}}
+{"question_id": "GEL2-0394", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KURAMOCHI_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CEP170: gene effect = -0.060, dependency probability = 0.052 \u2192 classified as non-essential\n- OR52N4: gene effect = 0.020, dependency probability = 0.016 \u2192 classified as non-essential\n- AFF4: gene effect = -0.021, dependency probability = 0.017 \u2192 classified as non-essential", "gold_answer": "CEP170", "gold_category": "depmap", "gold_extraction": {"cell_line": "KURAMOCHI_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "CEP170", "cell_line": "KURAMOCHI_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0601495878096939}, {"gene_name": "OR52N4", "cell_line": "KURAMOCHI_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0196758106210797}, {"gene_name": "AFF4", "cell_line": "KURAMOCHI_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0213639109342552}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["CEP170", "OR52N4", "AFF4"], "cell_line": "KURAMOCHI_OVARY"}}
+{"question_id": "GEL2-0395", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CAL29_URINARY_TRACT (Bladder/Urinary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FCHO2: gene effect = -0.755, dependency probability = 0.896 \u2192 classified as non-essential", "gold_answer": "FCHO2", "gold_category": "depmap", "gold_extraction": {"cell_line": "CAL29_URINARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "FCHO2", "cell_line": "CAL29_URINARY_TRACT", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.7547207837851594}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["FCHO2"], "cell_line": "CAL29_URINARY_TRACT"}}
+{"question_id": "GEL2-0396", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NRH-GCT1 (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- IL3: gene effect = -0.093, dependency probability = 0.041 \u2192 classified as non-essential", "gold_answer": "IL3", "gold_category": "depmap", "gold_extraction": {"cell_line": "NRH-GCT1", "screen_type": "CRISPR", "genes": [{"gene_name": "IL3", "cell_line": "NRH-GCT1", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0932790419835613}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["IL3"], "cell_line": "NRH-GCT1"}}
+{"question_id": "GEL2-0397", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC78_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FLCN: gene effect = -0.124, dependency probability = 0.082 \u2192 classified as non-essential\n- TAF12: gene effect = -0.367, dependency probability = 0.266 \u2192 classified as non-essential", "gold_answer": "FLCN", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC78_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "FLCN", "cell_line": "HCC78_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1237677013197093}, {"gene_name": "TAF12", "cell_line": "HCC78_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3673084292881811}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["FLCN", "TAF12"], "cell_line": "HCC78_LUNG"}}
+{"question_id": "GEL2-0398", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TEN_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PMEPA1: gene effect = -0.225, dependency probability = 0.177 \u2192 classified as non-essential\n- APOL1: gene effect = 0.019, dependency probability = 0.013 \u2192 classified as non-essential", "gold_answer": "PMEPA1", "gold_category": "depmap", "gold_extraction": {"cell_line": "TEN_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "PMEPA1", "cell_line": "TEN_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2250625344961272}, {"gene_name": "APOL1", "cell_line": "TEN_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.018976870091866}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PMEPA1", "APOL1"], "cell_line": "TEN_ENDOMETRIUM"}}
+{"question_id": "GEL2-0399", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SW1463_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HLA-DQA2: gene effect = 0.030, dependency probability = 0.021 \u2192 classified as non-essential\n- CXCL2: gene effect = -0.182, dependency probability = 0.085 \u2192 classified as non-essential\n- NAA35: gene effect = -0.367, dependency probability = 0.306 \u2192 classified as non-essential", "gold_answer": "HLA-DQA2", "gold_category": "depmap", "gold_extraction": {"cell_line": "SW1463_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "HLA-DQA2", "cell_line": "SW1463_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0297440290042342}, {"gene_name": "CXCL2", "cell_line": "SW1463_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1817040339474416}, {"gene_name": "NAA35", "cell_line": "SW1463_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3669987981710374}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["HLA-DQA2", "CXCL2", "NAA35"], "cell_line": "SW1463_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0400", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JEG3_PLACENTA (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MS4A12: gene effect = 0.103, dependency probability = 0.008 \u2192 classified as non-essential", "gold_answer": "MS4A12", "gold_category": "depmap", "gold_extraction": {"cell_line": "JEG3_PLACENTA", "screen_type": "CRISPR", "genes": [{"gene_name": "MS4A12", "cell_line": "JEG3_PLACENTA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1025660745343565}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MS4A12"], "cell_line": "JEG3_PLACENTA"}}
+{"question_id": "GEL2-0401", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in A3KAW_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DAPL1: gene effect = -0.017, dependency probability = 0.019 \u2192 classified as non-essential", "gold_answer": "DAPL1", "gold_category": "depmap", "gold_extraction": {"cell_line": "A3KAW_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "DAPL1", "cell_line": "A3KAW_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0166768404395029}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DAPL1"], "cell_line": "A3KAW_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0402", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU840_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RBPMS: gene effect = -0.003, dependency probability = 0.025 \u2192 classified as non-essential\n- RTTN: gene effect = -0.167, dependency probability = 0.088 \u2192 classified as non-essential", "gold_answer": "RBPMS", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU840_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "RBPMS", "cell_line": "SNU840_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0025421074845463}, {"gene_name": "RTTN", "cell_line": "SNU840_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1671831097030883}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["RBPMS", "RTTN"], "cell_line": "SNU840_OVARY"}}
+{"question_id": "GEL2-0403", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZMYM5: gene effect = -0.057, dependency probability = 0.029 \u2192 classified as non-essential\n- FURIN: gene effect = -0.239, dependency probability = 0.230 \u2192 classified as non-essential", "gold_answer": "ZMYM5", "gold_category": "depmap", "gold_extraction": {"cell_line": "OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "ZMYM5", "cell_line": "OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0566799892948698}, {"gene_name": "FURIN", "cell_line": "OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2391944848173247}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ZMYM5", "FURIN"], "cell_line": "OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0404", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in DMS273_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HEXA: gene effect = 0.174, dependency probability = 0.003 \u2192 classified as non-essential\n- MMD2: gene effect = 0.057, dependency probability = 0.027 \u2192 classified as non-essential\n- IGFBP5: gene effect = 0.166, dependency probability = 0.006 \u2192 classified as non-essential", "gold_answer": "HEXA", "gold_category": "depmap", "gold_extraction": {"cell_line": "DMS273_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "HEXA", "cell_line": "DMS273_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1743912374513345}, {"gene_name": "MMD2", "cell_line": "DMS273_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0565159927742225}, {"gene_name": "IGFBP5", "cell_line": "DMS273_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.165615453496294}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["HEXA", "MMD2", "IGFBP5"], "cell_line": "DMS273_LUNG"}}
+{"question_id": "GEL2-0405", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OAW42_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DEGS2: gene effect = -0.162, dependency probability = 0.059 \u2192 classified as non-essential", "gold_answer": "DEGS2", "gold_category": "depmap", "gold_extraction": {"cell_line": "OAW42_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "DEGS2", "cell_line": "OAW42_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1615132020452193}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DEGS2"], "cell_line": "OAW42_OVARY"}}
+{"question_id": "GEL2-0406", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in IPC298_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- BBLN: gene effect = -0.084, dependency probability = 0.046 \u2192 classified as non-essential", "gold_answer": "BBLN", "gold_category": "depmap", "gold_extraction": {"cell_line": "IPC298_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "BBLN", "cell_line": "IPC298_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0839554815436872}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["BBLN"], "cell_line": "IPC298_SKIN"}}
+{"question_id": "GEL2-0407", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU739_LIVER (Liver) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ADGRF1: gene effect = -0.016, dependency probability = 0.034 \u2192 classified as non-essential\n- TMEM31: gene effect = 0.067, dependency probability = 0.009 \u2192 classified as non-essential", "gold_answer": "ADGRF1", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU739_LIVER", "screen_type": "CRISPR", "genes": [{"gene_name": "ADGRF1", "cell_line": "SNU739_LIVER", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0160365643829995}, {"gene_name": "TMEM31", "cell_line": "SNU739_LIVER", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0669449989115518}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ADGRF1", "TMEM31"], "cell_line": "SNU739_LIVER"}}
+{"question_id": "GEL2-0408", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in D283MED_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PDCD6IP: gene effect = -0.757, dependency probability = 0.898 \u2192 classified as non-essential\n- LHFPL6: gene effect = 0.272, dependency probability = 0.002 \u2192 classified as non-essential", "gold_answer": "PDCD6IP", "gold_category": "depmap", "gold_extraction": {"cell_line": "D283MED_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "PDCD6IP", "cell_line": "D283MED_CENTRAL_NERVOUS_SYSTEM", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.7568840529606161}, {"gene_name": "LHFPL6", "cell_line": "D283MED_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2722526704079964}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PDCD6IP", "LHFPL6"], "cell_line": "D283MED_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0409", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NO10_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ANKRD6: gene effect = -0.146, dependency probability = 0.097 \u2192 classified as non-essential\n- SPATA20: gene effect = -0.249, dependency probability = 0.160 \u2192 classified as non-essential\n- RIPOR1: gene effect = 0.172, dependency probability = 0.005 \u2192 classified as non-essential", "gold_answer": "ANKRD6", "gold_category": "depmap", "gold_extraction": {"cell_line": "NO10_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "ANKRD6", "cell_line": "NO10_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1458559966764237}, {"gene_name": "SPATA20", "cell_line": "NO10_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2491771589700832}, {"gene_name": "RIPOR1", "cell_line": "NO10_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1720846029350453}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["ANKRD6", "SPATA20", "RIPOR1"], "cell_line": "NO10_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0410", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in A427_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DENR: gene effect = -0.589, dependency probability = 0.586 \u2192 classified as non-essential", "gold_answer": "DENR", "gold_category": "depmap", "gold_extraction": {"cell_line": "A427_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "DENR", "cell_line": "A427_LUNG", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.5890577956798435}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DENR"], "cell_line": "A427_LUNG"}}
+{"question_id": "GEL2-0411", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GFI1B: gene effect = -0.009, dependency probability = 0.023 \u2192 classified as non-essential", "gold_answer": "GFI1B", "gold_category": "depmap", "gold_extraction": {"cell_line": "SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "GFI1B", "cell_line": "SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0085584379061062}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["GFI1B"], "cell_line": "SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0412", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PEA1_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- B3GNTL1: gene effect = 0.135, dependency probability = 0.008 \u2192 classified as non-essential\n- PRRC1: gene effect = 0.100, dependency probability = 0.010 \u2192 classified as non-essential", "gold_answer": "B3GNTL1", "gold_category": "depmap", "gold_extraction": {"cell_line": "PEA1_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "B3GNTL1", "cell_line": "PEA1_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1352868012348746}, {"gene_name": "PRRC1", "cell_line": "PEA1_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0999143111758294}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["B3GNTL1", "PRRC1"], "cell_line": "PEA1_OVARY"}}
+{"question_id": "GEL2-0413", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in YH13_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HIP1: gene effect = 0.128, dependency probability = 0.007 \u2192 classified as non-essential\n- LRRC56: gene effect = -0.149, dependency probability = 0.079 \u2192 classified as non-essential", "gold_answer": "HIP1", "gold_category": "depmap", "gold_extraction": {"cell_line": "YH13_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "HIP1", "cell_line": "YH13_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1276263328697436}, {"gene_name": "LRRC56", "cell_line": "YH13_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1488648010268657}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["HIP1", "LRRC56"], "cell_line": "YH13_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0414", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SEMK2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HMGN4: gene effect = 0.051, dependency probability = 0.010 \u2192 classified as non-essential\n- WDR45: gene effect = -0.331, dependency probability = 0.201 \u2192 classified as non-essential\n- OPN5: gene effect = -0.038, dependency probability = 0.022 \u2192 classified as non-essential", "gold_answer": "HMGN4", "gold_category": "depmap", "gold_extraction": {"cell_line": "SEMK2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "HMGN4", "cell_line": "SEMK2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0508119444161054}, {"gene_name": "WDR45", "cell_line": "SEMK2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3311120090401909}, {"gene_name": "OPN5", "cell_line": "SEMK2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0384545530816504}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["HMGN4", "WDR45", "OPN5"], "cell_line": "SEMK2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0415", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KP1N_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DHODH: gene effect = -0.064, dependency probability = 0.055 \u2192 classified as non-essential", "gold_answer": "DHODH", "gold_category": "depmap", "gold_extraction": {"cell_line": "KP1N_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "DHODH", "cell_line": "KP1N_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0639614336437834}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DHODH"], "cell_line": "KP1N_PANCREAS"}}
+{"question_id": "GEL2-0416", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OVISE_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- UBXN8: gene effect = -0.154, dependency probability = 0.102 \u2192 classified as non-essential", "gold_answer": "UBXN8", "gold_category": "depmap", "gold_extraction": {"cell_line": "OVISE_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "UBXN8", "cell_line": "OVISE_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1538555085097787}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["UBXN8"], "cell_line": "OVISE_OVARY"}}
+{"question_id": "GEL2-0417", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RMSYM_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GCNA: gene effect = -0.128, dependency probability = 0.062 \u2192 classified as non-essential\n- EPHX3: gene effect = 0.008, dependency probability = 0.014 \u2192 classified as non-essential", "gold_answer": "GCNA", "gold_category": "depmap", "gold_extraction": {"cell_line": "RMSYM_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "GCNA", "cell_line": "RMSYM_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1276619426782791}, {"gene_name": "EPHX3", "cell_line": "RMSYM_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0084722899347144}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["GCNA", "EPHX3"], "cell_line": "RMSYM_SOFT_TISSUE"}}
+{"question_id": "GEL2-0418", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH747_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SHQ1: gene effect = -0.290, dependency probability = 0.285 \u2192 classified as non-essential\n- DPPA3: gene effect = -0.202, dependency probability = 0.098 \u2192 classified as non-essential", "gold_answer": "SHQ1", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH747_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "SHQ1", "cell_line": "NCIH747_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2895762105345486}, {"gene_name": "DPPA3", "cell_line": "NCIH747_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2019937643962439}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["SHQ1", "DPPA3"], "cell_line": "NCIH747_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0419", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RPMI7951_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RRP1B: gene effect = 0.104, dependency probability = 0.009 \u2192 classified as non-essential\n- BMS1: gene effect = -0.543, dependency probability = 0.746 \u2192 classified as non-essential\n- TRIAP1: gene effect = -0.762, dependency probability = 0.886 \u2192 classified as non-essential", "gold_answer": "RRP1B", "gold_category": "depmap", "gold_extraction": {"cell_line": "RPMI7951_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "RRP1B", "cell_line": "RPMI7951_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1036579322651457}, {"gene_name": "BMS1", "cell_line": "RPMI7951_SKIN", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.5426374302217178}, {"gene_name": "TRIAP1", "cell_line": "RPMI7951_SKIN", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.7616189222950572}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["RRP1B", "BMS1", "TRIAP1"], "cell_line": "RPMI7951_SKIN"}}
+{"question_id": "GEL2-0420", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in BB30HNC_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZNF506: gene effect = -0.102, dependency probability = 0.037 \u2192 classified as non-essential", "gold_answer": "ZNF506", "gold_category": "depmap", "gold_extraction": {"cell_line": "BB30HNC_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "ZNF506", "cell_line": "BB30HNC_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1021689314209789}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ZNF506"], "cell_line": "BB30HNC_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0421", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MOLM14_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GPR50: gene effect = -0.018, dependency probability = 0.023 \u2192 classified as non-essential", "gold_answer": "GPR50", "gold_category": "depmap", "gold_extraction": {"cell_line": "MOLM14_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "GPR50", "cell_line": "MOLM14_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0182337027076966}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["GPR50"], "cell_line": "MOLM14_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0422", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HMY1_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PIP5K1C: gene effect = -0.046, dependency probability = 0.032 \u2192 classified as non-essential\n- CPSF1: gene effect = -0.328, dependency probability = 0.202 \u2192 classified as non-essential", "gold_answer": "PIP5K1C", "gold_category": "depmap", "gold_extraction": {"cell_line": "HMY1_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "PIP5K1C", "cell_line": "HMY1_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.046487018598372}, {"gene_name": "CPSF1", "cell_line": "HMY1_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3275694946198638}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PIP5K1C", "CPSF1"], "cell_line": "HMY1_SKIN"}}
+{"question_id": "GEL2-0423", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OVCAR5_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- FDXR: gene effect = -0.367, dependency probability = 0.447 \u2192 classified as non-essential\n- HIBCH: gene effect = -0.052, dependency probability = 0.030 \u2192 classified as non-essential", "gold_answer": "FDXR", "gold_category": "depmap", "gold_extraction": {"cell_line": "OVCAR5_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "FDXR", "cell_line": "OVCAR5_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3671213087499179}, {"gene_name": "HIBCH", "cell_line": "OVCAR5_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0523991602333559}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["FDXR", "HIBCH"], "cell_line": "OVCAR5_OVARY"}}
+{"question_id": "GEL2-0424", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CAOV4_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- H3C1: gene effect = -0.455, dependency probability = 0.414 \u2192 classified as non-essential\n- PPP4R1: gene effect = -0.062, dependency probability = 0.036 \u2192 classified as non-essential\n- EPB41L4A: gene effect = -0.062, dependency probability = 0.036 \u2192 classified as non-essential", "gold_answer": "H3C1", "gold_category": "depmap", "gold_extraction": {"cell_line": "CAOV4_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "H3C1", "cell_line": "CAOV4_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.455143052355403}, {"gene_name": "PPP4R1", "cell_line": "CAOV4_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.061991414658459}, {"gene_name": "EPB41L4A", "cell_line": "CAOV4_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0617218379859487}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["H3C1", "PPP4R1", "EPB41L4A"], "cell_line": "CAOV4_OVARY"}}
+{"question_id": "GEL2-0425", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU1077_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DUS4L: gene effect = -0.040, dependency probability = 0.040 \u2192 classified as non-essential", "gold_answer": "DUS4L", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU1077_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "DUS4L", "cell_line": "SNU1077_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0404246803569514}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DUS4L"], "cell_line": "SNU1077_ENDOMETRIUM"}}
+{"question_id": "GEL2-0426", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DCAF4L1: gene effect = 0.053, dependency probability = 0.011 \u2192 classified as non-essential", "gold_answer": "DCAF4L1", "gold_category": "depmap", "gold_extraction": {"cell_line": "MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "DCAF4L1", "cell_line": "MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0533904165676523}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DCAF4L1"], "cell_line": "MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0427", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH838_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZIM3: gene effect = 0.100 \u2192 classified as non-essential\n- ST3GAL6: gene effect = -0.156, dependency probability = 0.064 \u2192 classified as non-essential", "gold_answer": "ZIM3", "gold_category": "demeter2", "gold_extraction": {"cell_line": "NCIH838_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "ZIM3", "cell_line": "NCIH838_LUNG", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": 0.0997731996281}, {"gene_name": "ST3GAL6", "cell_line": "NCIH838_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1558478897008464}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "demeter2", "gene_symbols": ["ZIM3", "ST3GAL6"], "cell_line": "NCIH838_LUNG"}}
+{"question_id": "GEL2-0428", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HT144_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- EPPIN: gene effect = 0.184, dependency probability = 0.004 \u2192 classified as non-essential\n- GARNL3: gene effect = -0.023, dependency probability = 0.030 \u2192 classified as non-essential", "gold_answer": "EPPIN", "gold_category": "depmap", "gold_extraction": {"cell_line": "HT144_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "EPPIN", "cell_line": "HT144_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1842792190639857}, {"gene_name": "GARNL3", "cell_line": "HT144_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0233787614878821}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["EPPIN", "GARNL3"], "cell_line": "HT144_SKIN"}}
+{"question_id": "GEL2-0429", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SUM185PE_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- C16orf89: gene effect = 0.017, dependency probability = 0.017 \u2192 classified as non-essential\n- CHRNG: gene effect = -0.172, dependency probability = 0.066 \u2192 classified as non-essential\n- TGFBR3: gene effect = -0.211, dependency probability = 0.110 \u2192 classified as non-essential", "gold_answer": "C16orf89", "gold_category": "depmap", "gold_extraction": {"cell_line": "SUM185PE_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "C16orf89", "cell_line": "SUM185PE_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0165848000380133}, {"gene_name": "CHRNG", "cell_line": "SUM185PE_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.171801284363698}, {"gene_name": "TGFBR3", "cell_line": "SUM185PE_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.210717997815068}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["C16orf89", "CHRNG", "TGFBR3"], "cell_line": "SUM185PE_BREAST"}}
+{"question_id": "GEL2-0430", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in T98G_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MINAR1: gene effect = 0.024, dependency probability = 0.029 \u2192 classified as non-essential", "gold_answer": "MINAR1", "gold_category": "depmap", "gold_extraction": {"cell_line": "T98G_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "MINAR1", "cell_line": "T98G_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0242959866455016}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MINAR1"], "cell_line": "T98G_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0431", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HSD3B7: gene effect = -0.169, dependency probability = 0.066 \u2192 classified as non-essential", "gold_answer": "HSD3B7", "gold_category": "depmap", "gold_extraction": {"cell_line": "EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "HSD3B7", "cell_line": "EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1685305236386102}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["HSD3B7"], "cell_line": "EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0432", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MESOV_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RARB: gene effect = 0.049, dependency probability = 0.011 \u2192 classified as non-essential\n- RGS9: gene effect = 0.066, dependency probability = 0.008 \u2192 classified as non-essential", "gold_answer": "RARB", "gold_category": "depmap", "gold_extraction": {"cell_line": "MESOV_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "RARB", "cell_line": "MESOV_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0494335350318499}, {"gene_name": "RGS9", "cell_line": "MESOV_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0660781578954279}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["RARB", "RGS9"], "cell_line": "MESOV_OVARY"}}
+{"question_id": "GEL2-0433", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in YAPC_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ARMC12: gene effect = 0.106, dependency probability = 0.010 \u2192 classified as non-essential\n- EGF: gene effect = 0.009, dependency probability = 0.014 \u2192 classified as non-essential", "gold_answer": "ARMC12", "gold_category": "depmap", "gold_extraction": {"cell_line": "YAPC_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "ARMC12", "cell_line": "YAPC_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.106479167341121}, {"gene_name": "EGF", "cell_line": "YAPC_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.009090374350048}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ARMC12", "EGF"], "cell_line": "YAPC_PANCREAS"}}
+{"question_id": "GEL2-0434", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in LC1SQSF_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TYR: gene effect = -0.125 \u2192 classified as non-essential\n- CCNO: gene effect = 0.119, dependency probability = 0.008 \u2192 classified as non-essential\n- OR9G4: gene effect = -0.027, dependency probability = 0.026 \u2192 classified as non-essential", "gold_answer": "TYR", "gold_category": "demeter2", "gold_extraction": {"cell_line": "LC1SQSF_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "TYR", "cell_line": "LC1SQSF_LUNG", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.125045631799}, {"gene_name": "CCNO", "cell_line": "LC1SQSF_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1185969749544085}, {"gene_name": "OR9G4", "cell_line": "LC1SQSF_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0272554593982548}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "demeter2", "gene_symbols": ["TYR", "CCNO", "OR9G4"], "cell_line": "LC1SQSF_LUNG"}}
+{"question_id": "GEL2-0435", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCA1_CERVIX (Cervix) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CSF2RB: gene effect = -0.132, dependency probability = 0.099 \u2192 classified as non-essential", "gold_answer": "CSF2RB", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCA1_CERVIX", "screen_type": "CRISPR", "genes": [{"gene_name": "CSF2RB", "cell_line": "HCA1_CERVIX", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1318873520784933}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CSF2RB"], "cell_line": "HCA1_CERVIX"}}
+{"question_id": "GEL2-0436", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JVE207_COLON (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- LY6L: gene effect = -0.257, dependency probability = 0.121 \u2192 classified as non-essential", "gold_answer": "LY6L", "gold_category": "depmap", "gold_extraction": {"cell_line": "JVE207_COLON", "screen_type": "CRISPR", "genes": [{"gene_name": "LY6L", "cell_line": "JVE207_COLON", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2568541407899365}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["LY6L"], "cell_line": "JVE207_COLON"}}
+{"question_id": "GEL2-0437", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in BFTC905_URINARY_TRACT (Bladder/Urinary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GNA15: gene effect = 0.131, dependency probability = 0.003 \u2192 classified as non-essential\n- PDE4C: gene effect = -0.081, dependency probability = 0.043 \u2192 classified as non-essential", "gold_answer": "GNA15", "gold_category": "depmap", "gold_extraction": {"cell_line": "BFTC905_URINARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "GNA15", "cell_line": "BFTC905_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1311453727856288}, {"gene_name": "PDE4C", "cell_line": "BFTC905_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0808886322783148}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["GNA15", "PDE4C"], "cell_line": "BFTC905_URINARY_TRACT"}}
+{"question_id": "GEL2-0438", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HS695T_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PXMP2: gene effect = -0.248, dependency probability = 0.163 \u2192 classified as non-essential\n- SMTNL2: gene effect = -0.138, dependency probability = 0.077 \u2192 classified as non-essential", "gold_answer": "PXMP2", "gold_category": "depmap", "gold_extraction": {"cell_line": "HS695T_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "PXMP2", "cell_line": "HS695T_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2480726483451386}, {"gene_name": "SMTNL2", "cell_line": "HS695T_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1379164211144085}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PXMP2", "SMTNL2"], "cell_line": "HS695T_SKIN"}}
+{"question_id": "GEL2-0439", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in P4E6_PROSTATE (Prostate) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ARPC1A: gene effect = -0.053, dependency probability = 0.036 \u2192 classified as non-essential\n- NUCB2: gene effect = 0.552, dependency probability = 0.000 \u2192 classified as non-essential\n- PIK3C2A: gene effect = -0.183, dependency probability = 0.136 \u2192 classified as non-essential", "gold_answer": "ARPC1A", "gold_category": "depmap", "gold_extraction": {"cell_line": "P4E6_PROSTATE", "screen_type": "CRISPR", "genes": [{"gene_name": "ARPC1A", "cell_line": "P4E6_PROSTATE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0531848006334827}, {"gene_name": "NUCB2", "cell_line": "P4E6_PROSTATE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.5518361139852068}, {"gene_name": "PIK3C2A", "cell_line": "P4E6_PROSTATE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1827402589337825}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["ARPC1A", "NUCB2", "PIK3C2A"], "cell_line": "P4E6_PROSTATE"}}
+{"question_id": "GEL2-0440", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in M140325_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ICAM5: gene effect = -0.356, dependency probability = 0.346 \u2192 classified as non-essential", "gold_answer": "ICAM5", "gold_category": "depmap", "gold_extraction": {"cell_line": "M140325_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "ICAM5", "cell_line": "M140325_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3560668880523578}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ICAM5"], "cell_line": "M140325_SKIN"}}
+{"question_id": "GEL2-0441", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in 538MGBA_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MYG1: gene effect = -0.256, dependency probability = 0.258 \u2192 classified as non-essential", "gold_answer": "MYG1", "gold_category": "depmap", "gold_extraction": {"cell_line": "538MGBA_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "MYG1", "cell_line": "538MGBA_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2555458439965848}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["MYG1"], "cell_line": "538MGBA_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0442", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in A3KAW_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- OR6K2: gene effect = -0.019, dependency probability = 0.019 \u2192 classified as non-essential\n- PLCG1: gene effect = 0.195, dependency probability = 0.002 \u2192 classified as non-essential", "gold_answer": "OR6K2", "gold_category": "depmap", "gold_extraction": {"cell_line": "A3KAW_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "OR6K2", "cell_line": "A3KAW_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0190270541757664}, {"gene_name": "PLCG1", "cell_line": "A3KAW_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1954236846598124}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["OR6K2", "PLCG1"], "cell_line": "A3KAW_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0443", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in PATU8988T_PANCREAS (Pancreas) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ADGRG6: gene effect = 0.005, dependency probability = 0.025 \u2192 classified as non-essential\n- RPL36AL: gene effect = -0.790, dependency probability = 0.844 \u2192 classified as non-essential", "gold_answer": "ADGRG6", "gold_category": "depmap", "gold_extraction": {"cell_line": "PATU8988T_PANCREAS", "screen_type": "CRISPR", "genes": [{"gene_name": "ADGRG6", "cell_line": "PATU8988T_PANCREAS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0046258941276009}, {"gene_name": "RPL36AL", "cell_line": "PATU8988T_PANCREAS", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.7895695487879799}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["ADGRG6", "RPL36AL"], "cell_line": "PATU8988T_PANCREAS"}}
+{"question_id": "GEL2-0444", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Myeloid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PPP1R17: gene effect = 0.326, dependency probability = 0.002 \u2192 classified as non-essential\n- ZNF674: gene effect = -0.264, dependency probability = 0.134 \u2192 classified as non-essential\n- TUBA1C: gene effect = -0.517, dependency probability = 0.593 \u2192 classified as non-essential", "gold_answer": "PPP1R17", "gold_category": "depmap", "gold_extraction": {"cell_line": "MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "PPP1R17", "cell_line": "MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.3257200802617045}, {"gene_name": "ZNF674", "cell_line": "MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.264466984383707}, {"gene_name": "TUBA1C", "cell_line": "MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.517233397234875}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["PPP1R17", "ZNF674", "TUBA1C"], "cell_line": "MUTZ8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0445", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HS683_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PLRG1: gene effect = -0.730, dependency probability = 0.855 \u2192 classified as non-essential", "gold_answer": "PLRG1", "gold_category": "depmap", "gold_extraction": {"cell_line": "HS683_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "PLRG1", "cell_line": "HS683_CENTRAL_NERVOUS_SYSTEM", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.7303037249155092}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PLRG1"], "cell_line": "HS683_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0446", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HB1119_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ITLN2: gene effect = 0.042, dependency probability = 0.011 \u2192 classified as non-essential", "gold_answer": "ITLN2", "gold_category": "depmap", "gold_extraction": {"cell_line": "HB1119_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "ITLN2", "cell_line": "HB1119_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0421564781482752}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ITLN2"], "cell_line": "HB1119_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0447", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCC38_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NOP56: gene effect = -0.600, dependency probability = 0.553 \u2192 classified as non-essential\n- SLC17A5: gene effect = 0.098, dependency probability = 0.008 \u2192 classified as non-essential", "gold_answer": "NOP56", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCC38_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "NOP56", "cell_line": "HCC38_BREAST", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.599663631190367}, {"gene_name": "SLC17A5", "cell_line": "HCC38_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0984554953295575}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["NOP56", "SLC17A5"], "cell_line": "HCC38_BREAST"}}
+{"question_id": "GEL2-0448", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JAR_PLACENTA (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SCNN1D: gene effect = -0.369, dependency probability = 0.349 \u2192 classified as non-essential\n- POLQ: gene effect = -0.284, dependency probability = 0.136 \u2192 classified as non-essential", "gold_answer": "SCNN1D", "gold_category": "depmap", "gold_extraction": {"cell_line": "JAR_PLACENTA", "screen_type": "CRISPR", "genes": [{"gene_name": "SCNN1D", "cell_line": "JAR_PLACENTA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3689419485009538}, {"gene_name": "POLQ", "cell_line": "JAR_PLACENTA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.284326851775411}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["SCNN1D", "POLQ"], "cell_line": "JAR_PLACENTA"}}
+{"question_id": "GEL2-0449", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MELHO_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MREG: gene effect = -0.069, dependency probability = 0.027 \u2192 classified as non-essential\n- KRTAP16-1: gene effect = 0.026, dependency probability = 0.014 \u2192 classified as non-essential\n- HERPUD1: gene effect = 0.102, dependency probability = 0.012 \u2192 classified as non-essential", "gold_answer": "MREG", "gold_category": "depmap", "gold_extraction": {"cell_line": "MELHO_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "MREG", "cell_line": "MELHO_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0691974503911885}, {"gene_name": "KRTAP16-1", "cell_line": "MELHO_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0255277651219256}, {"gene_name": "HERPUD1", "cell_line": "MELHO_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1017743309712647}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["MREG", "KRTAP16-1", "HERPUD1"], "cell_line": "MELHO_SKIN"}}
+{"question_id": "GEL2-0450", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CCLFPEDS0008T_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- WDR47: gene effect = -0.199, dependency probability = 0.126 \u2192 classified as non-essential", "gold_answer": "WDR47", "gold_category": "depmap", "gold_extraction": {"cell_line": "CCLFPEDS0008T_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "WDR47", "cell_line": "CCLFPEDS0008T_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1986018159179245}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["WDR47"], "cell_line": "CCLFPEDS0008T_SOFT_TISSUE"}}
+{"question_id": "GEL2-0451", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TE4_OESOPHAGUS (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DNM3: gene effect = -0.261, dependency probability = 0.191 \u2192 classified as non-essential", "gold_answer": "DNM3", "gold_category": "depmap", "gold_extraction": {"cell_line": "TE4_OESOPHAGUS", "screen_type": "CRISPR", "genes": [{"gene_name": "DNM3", "cell_line": "TE4_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2608615387677691}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DNM3"], "cell_line": "TE4_OESOPHAGUS"}}
+{"question_id": "GEL2-0452", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HHUA_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CCNJL: gene effect = -0.037, dependency probability = 0.022 \u2192 classified as non-essential\n- WNT8A: gene effect = 0.050, dependency probability = 0.017 \u2192 classified as non-essential", "gold_answer": "CCNJL", "gold_category": "depmap", "gold_extraction": {"cell_line": "HHUA_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "CCNJL", "cell_line": "HHUA_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0366396591681748}, {"gene_name": "WNT8A", "cell_line": "HHUA_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0504374219754854}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CCNJL", "WNT8A"], "cell_line": "HHUA_ENDOMETRIUM"}}
+{"question_id": "GEL2-0453", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CAL33_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- EIF1AX: gene effect = 0.114, dependency probability = 0.003 \u2192 classified as non-essential\n- TCFL5: gene effect = -0.088, dependency probability = 0.063 \u2192 classified as non-essential", "gold_answer": "EIF1AX", "gold_category": "depmap", "gold_extraction": {"cell_line": "CAL33_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "EIF1AX", "cell_line": "CAL33_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1139263379200561}, {"gene_name": "TCFL5", "cell_line": "CAL33_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0884249417523781}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["EIF1AX", "TCFL5"], "cell_line": "CAL33_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0454", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OMM25_UVEA (Eye) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- BCLAF3: gene effect = 0.126, dependency probability = 0.005 \u2192 classified as non-essential\n- AMACR: gene effect = 0.110, dependency probability = 0.008 \u2192 classified as non-essential\n- VPS33A: gene effect = -0.195, dependency probability = 0.096 \u2192 classified as non-essential", "gold_answer": "BCLAF3", "gold_category": "depmap", "gold_extraction": {"cell_line": "OMM25_UVEA", "screen_type": "CRISPR", "genes": [{"gene_name": "BCLAF3", "cell_line": "OMM25_UVEA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1260647335417193}, {"gene_name": "AMACR", "cell_line": "OMM25_UVEA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1095275835970228}, {"gene_name": "VPS33A", "cell_line": "OMM25_UVEA", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1946518544731875}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["BCLAF3", "AMACR", "VPS33A"], "cell_line": "OMM25_UVEA"}}
+{"question_id": "GEL2-0455", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RH4_SOFT_TISSUE (Soft Tissue) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PPP1CC: gene effect = -0.172, dependency probability = 0.123 \u2192 classified as non-essential", "gold_answer": "PPP1CC", "gold_category": "depmap", "gold_extraction": {"cell_line": "RH4_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "PPP1CC", "cell_line": "RH4_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1720149055012562}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PPP1CC"], "cell_line": "RH4_SOFT_TISSUE"}}
+{"question_id": "GEL2-0456", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in COV644_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- OR8S1: gene effect = -0.104, dependency probability = 0.068 \u2192 classified as non-essential", "gold_answer": "OR8S1", "gold_category": "depmap", "gold_extraction": {"cell_line": "COV644_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "OR8S1", "cell_line": "COV644_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1044436279950265}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["OR8S1"], "cell_line": "COV644_OVARY"}}
+{"question_id": "GEL2-0457", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in LS411N_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CITED1: gene effect = -0.090, dependency probability = 0.046 \u2192 classified as non-essential\n- INS: gene effect = -0.401, dependency probability = 0.493 \u2192 classified as non-essential", "gold_answer": "CITED1", "gold_category": "depmap", "gold_extraction": {"cell_line": "LS411N_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "CITED1", "cell_line": "LS411N_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0898286743447661}, {"gene_name": "INS", "cell_line": "LS411N_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4012865190031792}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CITED1", "INS"], "cell_line": "LS411N_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0458", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KYM1_SOFT_TISSUE (Kidney) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- UEVLD: gene effect = 0.233, dependency probability = 0.001 \u2192 classified as non-essential\n- CCNO: gene effect = -0.052, dependency probability = 0.025 \u2192 classified as non-essential", "gold_answer": "UEVLD", "gold_category": "depmap", "gold_extraction": {"cell_line": "KYM1_SOFT_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "UEVLD", "cell_line": "KYM1_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.233237560094305}, {"gene_name": "CCNO", "cell_line": "KYM1_SOFT_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0522014825637136}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["UEVLD", "CCNO"], "cell_line": "KYM1_SOFT_TISSUE"}}
+{"question_id": "GEL2-0459", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HUG1N_STOMACH (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TMEM254: gene effect = -0.037, dependency probability = 0.021 \u2192 classified as non-essential\n- MAN1A1: gene effect = -0.141, dependency probability = 0.070 \u2192 classified as non-essential\n- ASPHD1: gene effect = 0.070, dependency probability = 0.015 \u2192 classified as non-essential", "gold_answer": "TMEM254", "gold_category": "depmap", "gold_extraction": {"cell_line": "HUG1N_STOMACH", "screen_type": "CRISPR", "genes": [{"gene_name": "TMEM254", "cell_line": "HUG1N_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0365384843587649}, {"gene_name": "MAN1A1", "cell_line": "HUG1N_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1406506263438187}, {"gene_name": "ASPHD1", "cell_line": "HUG1N_STOMACH", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0695549385050544}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["TMEM254", "MAN1A1", "ASPHD1"], "cell_line": "HUG1N_STOMACH"}}
+{"question_id": "GEL2-0460", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HEC6_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- REEP2: gene effect = -0.368, dependency probability = 0.257 \u2192 classified as non-essential", "gold_answer": "REEP2", "gold_category": "depmap", "gold_extraction": {"cell_line": "HEC6_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "REEP2", "cell_line": "HEC6_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3675327809008503}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["REEP2"], "cell_line": "HEC6_ENDOMETRIUM"}}
+{"question_id": "GEL2-0461", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KYSE220_OESOPHAGUS (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NEURL4: gene effect = -0.106, dependency probability = 0.061 \u2192 classified as non-essential", "gold_answer": "NEURL4", "gold_category": "depmap", "gold_extraction": {"cell_line": "KYSE220_OESOPHAGUS", "screen_type": "CRISPR", "genes": [{"gene_name": "NEURL4", "cell_line": "KYSE220_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1058908913095544}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["NEURL4"], "cell_line": "KYSE220_OESOPHAGUS"}}
+{"question_id": "GEL2-0462", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TY82_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MYOT: gene effect = -0.043, dependency probability = 0.025 \u2192 classified as non-essential\n- HDAC1: gene effect = 0.004, dependency probability = 0.018 \u2192 classified as non-essential", "gold_answer": "MYOT", "gold_category": "depmap", "gold_extraction": {"cell_line": "TY82_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "MYOT", "cell_line": "TY82_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0428465912181957}, {"gene_name": "HDAC1", "cell_line": "TY82_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.003526361411467}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["MYOT", "HDAC1"], "cell_line": "TY82_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0463", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HUO3N1_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CLEC20A: gene effect = -0.051, dependency probability = 0.047 \u2192 classified as non-essential\n- FAM13A: gene effect = 0.060, dependency probability = 0.018 \u2192 classified as non-essential", "gold_answer": "CLEC20A", "gold_category": "depmap", "gold_extraction": {"cell_line": "HUO3N1_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "CLEC20A", "cell_line": "HUO3N1_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0509550529372621}, {"gene_name": "FAM13A", "cell_line": "HUO3N1_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0599634066017222}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CLEC20A", "FAM13A"], "cell_line": "HUO3N1_BONE"}}
+{"question_id": "GEL2-0464", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OC314_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KCTD18: gene effect = 0.341, dependency probability = 0.002 \u2192 classified as non-essential\n- LCLAT1: gene effect = 0.142, dependency probability = 0.010 \u2192 classified as non-essential\n- F11: gene effect = -0.103, dependency probability = 0.035 \u2192 classified as non-essential", "gold_answer": "KCTD18", "gold_category": "depmap", "gold_extraction": {"cell_line": "OC314_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "KCTD18", "cell_line": "OC314_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.3413399897016175}, {"gene_name": "LCLAT1", "cell_line": "OC314_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1422956099703348}, {"gene_name": "F11", "cell_line": "OC314_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1029531396304929}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["KCTD18", "LCLAT1", "F11"], "cell_line": "OC314_OVARY"}}
+{"question_id": "GEL2-0465", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in CAL78_BONE (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NWD1: gene effect = -0.245, dependency probability = 0.179 \u2192 classified as non-essential", "gold_answer": "NWD1", "gold_category": "depmap", "gold_extraction": {"cell_line": "CAL78_BONE", "screen_type": "CRISPR", "genes": [{"gene_name": "NWD1", "cell_line": "CAL78_BONE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2445742346545096}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["NWD1"], "cell_line": "CAL78_BONE"}}
+{"question_id": "GEL2-0466", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SW756_CERVIX (Cervix) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NKX2-8: gene effect = 0.037, dependency probability = 0.015 \u2192 classified as non-essential", "gold_answer": "NKX2-8", "gold_category": "depmap", "gold_extraction": {"cell_line": "SW756_CERVIX", "screen_type": "CRISPR", "genes": [{"gene_name": "NKX2-8", "cell_line": "SW756_CERVIX", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.037188697691145}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["NKX2-8"], "cell_line": "SW756_CERVIX"}}
+{"question_id": "GEL2-0467", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NRH-GCT2 (Bone) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- MAB21L4: gene effect = 0.138, dependency probability = 0.003 \u2192 classified as non-essential\n- PDSS1: gene effect = -0.164, dependency probability = 0.084 \u2192 classified as non-essential", "gold_answer": "MAB21L4", "gold_category": "depmap", "gold_extraction": {"cell_line": "NRH-GCT2", "screen_type": "CRISPR", "genes": [{"gene_name": "MAB21L4", "cell_line": "NRH-GCT2", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1381029363766578}, {"gene_name": "PDSS1", "cell_line": "NRH-GCT2", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1642359427258531}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["MAB21L4", "PDSS1"], "cell_line": "NRH-GCT2"}}
+{"question_id": "GEL2-0468", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in VMRCLCD_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CD226: gene effect = 0.145, dependency probability = 0.014 \u2192 classified as non-essential\n- RASIP1: gene effect = -0.276, dependency probability = 0.244 \u2192 classified as non-essential", "gold_answer": "CD226", "gold_category": "depmap", "gold_extraction": {"cell_line": "VMRCLCD_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "CD226", "cell_line": "VMRCLCD_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1454370908997186}, {"gene_name": "RASIP1", "cell_line": "VMRCLCD_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2762762596405404}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["CD226", "RASIP1"], "cell_line": "VMRCLCD_LUNG"}}
+{"question_id": "GEL2-0469", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RNF187: gene effect = 0.524, dependency probability = 0.000 \u2192 classified as non-essential\n- TBXT: gene effect = 0.135 \u2192 classified as non-essential\n- PPP1R8: gene effect = -0.754, dependency probability = 0.906 \u2192 classified as non-essential", "gold_answer": "RNF187", "gold_category": "depmap", "gold_extraction": {"cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "RNF187", "cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.5237924034554838}, {"gene_name": "TBXT", "cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": 0.135053590664}, {"gene_name": "PPP1R8", "cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.7542624052857728}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["RNF187", "TBXT", "PPP1R8"], "cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0470", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU308_BILIARY_TRACT (Biliary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CTSV: gene effect = -0.111, dependency probability = 0.059 \u2192 classified as non-essential", "gold_answer": "CTSV", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU308_BILIARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "CTSV", "cell_line": "SNU308_BILIARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1106675031223681}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["CTSV"], "cell_line": "SNU308_BILIARY_TRACT"}}
+{"question_id": "GEL2-0471", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCCIT_TESTIS (Testis) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PAIP2B: gene effect = -0.079, dependency probability = 0.035 \u2192 classified as non-essential", "gold_answer": "PAIP2B", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCCIT_TESTIS", "screen_type": "CRISPR", "genes": [{"gene_name": "PAIP2B", "cell_line": "NCCIT_TESTIS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.078596542474868}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PAIP2B"], "cell_line": "NCCIT_TESTIS"}}
+{"question_id": "GEL2-0472", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- OR9K2: gene effect = -0.093, dependency probability = 0.028 \u2192 classified as non-essential\n- WDR88: gene effect = -0.264, dependency probability = 0.228 \u2192 classified as non-essential", "gold_answer": "OR9K2", "gold_category": "depmap", "gold_extraction": {"cell_line": "SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "OR9K2", "cell_line": "SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0928584092270151}, {"gene_name": "WDR88", "cell_line": "SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.26419451820687}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["OR9K2", "WDR88"], "cell_line": "SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0473", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HMC18_BREAST (Breast) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TMEM200C: gene effect = 0.148, dependency probability = 0.004 \u2192 classified as non-essential\n- CCDC197: gene effect = 0.007, dependency probability = 0.024 \u2192 classified as non-essential", "gold_answer": "TMEM200C", "gold_category": "depmap", "gold_extraction": {"cell_line": "HMC18_BREAST", "screen_type": "CRISPR", "genes": [{"gene_name": "TMEM200C", "cell_line": "HMC18_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.148203447782959}, {"gene_name": "CCDC197", "cell_line": "HMC18_BREAST", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.007283214639092}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["TMEM200C", "CCDC197"], "cell_line": "HMC18_BREAST"}}
+{"question_id": "GEL2-0474", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH1092_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PLEKHO1: gene effect = 0.089, dependency probability = 0.012 \u2192 classified as non-essential\n- KRTAP6-3: gene effect = -0.028, dependency probability = 0.037 \u2192 classified as non-essential\n- BAZ1B: gene effect = -0.265, dependency probability = 0.257 \u2192 classified as non-essential", "gold_answer": "PLEKHO1", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH1092_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "PLEKHO1", "cell_line": "NCIH1092_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0887434097173599}, {"gene_name": "KRTAP6-3", "cell_line": "NCIH1092_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.027940563809523}, {"gene_name": "BAZ1B", "cell_line": "NCIH1092_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.2654867966454856}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["PLEKHO1", "KRTAP6-3", "BAZ1B"], "cell_line": "NCIH1092_LUNG"}}
+{"question_id": "GEL2-0475", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in MM485_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- IBA57: gene effect = -0.142, dependency probability = 0.047 \u2192 classified as non-essential", "gold_answer": "IBA57", "gold_category": "depmap", "gold_extraction": {"cell_line": "MM485_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "IBA57", "cell_line": "MM485_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1415919705474802}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["IBA57"], "cell_line": "MM485_SKIN"}}
+{"question_id": "GEL2-0476", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OC316_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- DEFB127: gene effect = 0.042, dependency probability = 0.011 \u2192 classified as non-essential", "gold_answer": "DEFB127", "gold_category": "depmap", "gold_extraction": {"cell_line": "OC316_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "DEFB127", "cell_line": "OC316_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0415852786239522}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["DEFB127"], "cell_line": "OC316_OVARY"}}
+{"question_id": "GEL2-0477", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HEC251_ENDOMETRIUM (Uterus) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CNTNAP5: gene effect = -0.012 \u2192 classified as non-essential\n- PTRHD1: gene effect = 0.017, dependency probability = 0.015 \u2192 classified as non-essential", "gold_answer": "CNTNAP5", "gold_category": "demeter2", "gold_extraction": {"cell_line": "HEC251_ENDOMETRIUM", "screen_type": "CRISPR", "genes": [{"gene_name": "CNTNAP5", "cell_line": "HEC251_ENDOMETRIUM", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.0117855244872}, {"gene_name": "PTRHD1", "cell_line": "HEC251_ENDOMETRIUM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0166876456350157}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "demeter2", "gene_symbols": ["CNTNAP5", "PTRHD1"], "cell_line": "HEC251_ENDOMETRIUM"}}
+{"question_id": "GEL2-0478", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UPCISCC154_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GAP43: gene effect = 0.120, dependency probability = 0.006 \u2192 classified as non-essential\n- PEX5L: gene effect = 0.082, dependency probability = 0.018 \u2192 classified as non-essential", "gold_answer": "GAP43", "gold_category": "depmap", "gold_extraction": {"cell_line": "UPCISCC154_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "GAP43", "cell_line": "UPCISCC154_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1203503949899199}, {"gene_name": "PEX5L", "cell_line": "UPCISCC154_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0821407909389101}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["GAP43", "PEX5L"], "cell_line": "UPCISCC154_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0479", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH2291_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- USP38: gene effect = 0.076, dependency probability = 0.015 \u2192 classified as non-essential\n- ANKS1A: gene effect = -0.028, dependency probability = 0.021 \u2192 classified as non-essential\n- SYNC: gene effect = -0.060, dependency probability = 0.039 \u2192 classified as non-essential", "gold_answer": "USP38", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH2291_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "USP38", "cell_line": "NCIH2291_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0760794361472448}, {"gene_name": "ANKS1A", "cell_line": "NCIH2291_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0281933622092506}, {"gene_name": "SYNC", "cell_line": "NCIH2291_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0595296195931105}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["USP38", "ANKS1A", "SYNC"], "cell_line": "NCIH2291_LUNG"}}
+{"question_id": "GEL2-0480", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCCIT_TESTIS (Testis) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- EREG: gene effect = -0.055, dependency probability = 0.029 \u2192 classified as non-essential", "gold_answer": "EREG", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCCIT_TESTIS", "screen_type": "CRISPR", "genes": [{"gene_name": "EREG", "cell_line": "NCCIT_TESTIS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0552529222709013}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["EREG"], "cell_line": "NCCIT_TESTIS"}}
+{"question_id": "GEL2-0481", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- RMND1: gene effect = -0.226, dependency probability = 0.140 \u2192 classified as non-essential", "gold_answer": "RMND1", "gold_category": "depmap", "gold_extraction": {"cell_line": "OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "RMND1", "cell_line": "OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.225944788099926}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["RMND1"], "cell_line": "OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0482", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in UMUC3_URINARY_TRACT (Bladder/Urinary Tract) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GRIK5: gene effect = -0.193, dependency probability = 0.161 \u2192 classified as non-essential\n- TTC4: gene effect = -0.141, dependency probability = 0.074 \u2192 classified as non-essential", "gold_answer": "GRIK5", "gold_category": "depmap", "gold_extraction": {"cell_line": "UMUC3_URINARY_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "GRIK5", "cell_line": "UMUC3_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1929254098624174}, {"gene_name": "TTC4", "cell_line": "UMUC3_URINARY_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1411211624245504}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["GRIK5", "TTC4"], "cell_line": "UMUC3_URINARY_TRACT"}}
+{"question_id": "GEL2-0483", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SKMEL24_SKIN (Skin) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- NSMCE4A: gene effect = -0.045, dependency probability = 0.057 \u2192 classified as non-essential\n- VAX1: gene effect = 0.184, dependency probability = 0.005 \u2192 classified as non-essential", "gold_answer": "NSMCE4A", "gold_category": "depmap", "gold_extraction": {"cell_line": "SKMEL24_SKIN", "screen_type": "CRISPR", "genes": [{"gene_name": "NSMCE4A", "cell_line": "SKMEL24_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0454076775156083}, {"gene_name": "VAX1", "cell_line": "SKMEL24_SKIN", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1843485266108294}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["NSMCE4A", "VAX1"], "cell_line": "SKMEL24_SKIN"}}
+{"question_id": "GEL2-0484", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JVE015_COLON (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- C8B: gene effect = 0.265, dependency probability = 0.004 \u2192 classified as non-essential\n- NKAPD1: gene effect = -0.371, dependency probability = 0.315 \u2192 classified as non-essential\n- ST14: gene effect = -0.092, dependency probability = 0.069 \u2192 classified as non-essential", "gold_answer": "C8B", "gold_category": "depmap", "gold_extraction": {"cell_line": "JVE015_COLON", "screen_type": "CRISPR", "genes": [{"gene_name": "C8B", "cell_line": "JVE015_COLON", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2652844789610673}, {"gene_name": "NKAPD1", "cell_line": "JVE015_COLON", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.3710693246581983}, {"gene_name": "ST14", "cell_line": "JVE015_COLON", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0918189775392379}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["C8B", "NKAPD1", "ST14"], "cell_line": "JVE015_COLON"}}
+{"question_id": "GEL2-0485", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OCIP5X_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- KMT5B: gene effect = -0.063, dependency probability = 0.029 \u2192 classified as non-essential", "gold_answer": "KMT5B", "gold_category": "depmap", "gold_extraction": {"cell_line": "OCIP5X_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "KMT5B", "cell_line": "OCIP5X_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0626953661456346}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["KMT5B"], "cell_line": "OCIP5X_OVARY"}}
+{"question_id": "GEL2-0486", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU626_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TM2D3: gene effect = -0.472, dependency probability = 0.296 \u2192 classified as non-essential", "gold_answer": "TM2D3", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU626_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "TM2D3", "cell_line": "SNU626_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4724770022364566}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["TM2D3"], "cell_line": "SNU626_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0487", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in KNS81_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PPIA: gene effect = -0.690, dependency probability = 0.651 \u2192 classified as non-essential\n- MRPS21: gene effect = -0.541, dependency probability = 0.726 \u2192 classified as non-essential", "gold_answer": "PPIA", "gold_category": "depmap", "gold_extraction": {"cell_line": "KNS81_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "PPIA", "cell_line": "KNS81_CENTRAL_NERVOUS_SYSTEM", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.6901758107822834}, {"gene_name": "MRPS21", "cell_line": "KNS81_CENTRAL_NERVOUS_SYSTEM", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.5405883865375135}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["PPIA", "MRPS21"], "cell_line": "KNS81_CENTRAL_NERVOUS_SYSTEM"}}
+{"question_id": "GEL2-0488", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in C4II_CERVIX (Cervix) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- GABRA6: gene effect = 0.115, dependency probability = 0.006 \u2192 classified as non-essential\n- CLDN5: gene effect = -0.007, dependency probability = 0.019 \u2192 classified as non-essential", "gold_answer": "GABRA6", "gold_category": "depmap", "gold_extraction": {"cell_line": "C4II_CERVIX", "screen_type": "CRISPR", "genes": [{"gene_name": "GABRA6", "cell_line": "C4II_CERVIX", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1153749225987314}, {"gene_name": "CLDN5", "cell_line": "C4II_CERVIX", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0068414897929027}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["GABRA6", "CLDN5"], "cell_line": "C4II_CERVIX"}}
+{"question_id": "GEL2-0489", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in NCIH1355_LUNG (Lung) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PKM: gene effect = -0.687, dependency probability = 0.766 \u2192 classified as non-essential\n- MICAL1: gene effect = 0.105, dependency probability = 0.012 \u2192 classified as non-essential\n- CTSD: gene effect = 0.305, dependency probability = 0.002 \u2192 classified as non-essential", "gold_answer": "PKM", "gold_category": "depmap", "gold_extraction": {"cell_line": "NCIH1355_LUNG", "screen_type": "CRISPR", "genes": [{"gene_name": "PKM", "cell_line": "NCIH1355_LUNG", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.68731503090876}, {"gene_name": "MICAL1", "cell_line": "NCIH1355_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1054343681859852}, {"gene_name": "CTSD", "cell_line": "NCIH1355_LUNG", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.3049473436962542}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["PKM", "MICAL1", "CTSD"], "cell_line": "NCIH1355_LUNG"}}
+{"question_id": "GEL2-0490", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HOTHC_THYROID (Thyroid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- SPATA19: gene effect = 0.231, dependency probability = 0.004 \u2192 classified as non-essential", "gold_answer": "SPATA19", "gold_category": "depmap", "gold_extraction": {"cell_line": "HOTHC_THYROID", "screen_type": "CRISPR", "genes": [{"gene_name": "SPATA19", "cell_line": "HOTHC_THYROID", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.2312292349581522}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["SPATA19"], "cell_line": "HOTHC_THYROID"}}
+{"question_id": "GEL2-0491", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCS2_CERVIX (Cervix) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- PKHD1L1: gene effect = 0.067, dependency probability = 0.011 \u2192 classified as non-essential", "gold_answer": "PKHD1L1", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCS2_CERVIX", "screen_type": "CRISPR", "genes": [{"gene_name": "PKHD1L1", "cell_line": "HCS2_CERVIX", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0670560757893646}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["PKHD1L1"], "cell_line": "HCS2_CERVIX"}}
+{"question_id": "GEL2-0492", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TMPRSS11F: gene effect = 0.069, dependency probability = 0.011 \u2192 classified as non-essential\n- LHX6: gene effect = -0.074, dependency probability = 0.038 \u2192 classified as non-essential", "gold_answer": "TMPRSS11F", "gold_category": "depmap", "gold_extraction": {"cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "TMPRSS11F", "cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0690269668401798}, {"gene_name": "LHX6", "cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0741172853039449}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["TMPRSS11F", "LHX6"], "cell_line": "RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0493", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in TE1_OESOPHAGUS (Esophagus/Stomach) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- HMGN2: gene effect = -0.524, dependency probability = 0.679 \u2192 classified as non-essential\n- GCHFR: gene effect = -0.063, dependency probability = 0.051 \u2192 classified as non-essential", "gold_answer": "HMGN2", "gold_category": "depmap", "gold_extraction": {"cell_line": "TE1_OESOPHAGUS", "screen_type": "CRISPR", "genes": [{"gene_name": "HMGN2", "cell_line": "TE1_OESOPHAGUS", "screen_method": "RNAi", "essentiality_status": "non-essential", "dependency_score": -0.5241232040837233}, {"gene_name": "GCHFR", "cell_line": "TE1_OESOPHAGUS", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0628230488585144}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["HMGN2", "GCHFR"], "cell_line": "TE1_OESOPHAGUS"}}
+{"question_id": "GEL2-0494", "task": "ge-l2", "split": "val", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in HCT15_LARGE_INTESTINE (Bowel) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ATP4A: gene effect = -0.052, dependency probability = 0.043 \u2192 classified as non-essential\n- ROBO4: gene effect = 0.139, dependency probability = 0.006 \u2192 classified as non-essential\n- TMEM97: gene effect = -0.126, dependency probability = 0.100 \u2192 classified as non-essential", "gold_answer": "ATP4A", "gold_category": "depmap", "gold_extraction": {"cell_line": "HCT15_LARGE_INTESTINE", "screen_type": "CRISPR", "genes": [{"gene_name": "ATP4A", "cell_line": "HCT15_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.0520405511104705}, {"gene_name": "ROBO4", "cell_line": "HCT15_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1393913339866824}, {"gene_name": "TMEM97", "cell_line": "HCT15_LARGE_INTESTINE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1255395640146834}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["ATP4A", "ROBO4", "TMEM97"], "cell_line": "HCT15_LARGE_INTESTINE"}}
+{"question_id": "GEL2-0495", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in OVCAR8_OVARY (Ovary/Fallopian Tube) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- ZSCAN12: gene effect = -0.107, dependency probability = 0.056 \u2192 classified as non-essential", "gold_answer": "ZSCAN12", "gold_category": "depmap", "gold_extraction": {"cell_line": "OVCAR8_OVARY", "screen_type": "CRISPR", "genes": [{"gene_name": "ZSCAN12", "cell_line": "OVCAR8_OVARY", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1070193873294666}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["ZSCAN12"], "cell_line": "OVCAR8_OVARY"}}
+{"question_id": "GEL2-0496", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JHU029_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- TADA1: gene effect = -0.179, dependency probability = 0.132 \u2192 classified as non-essential", "gold_answer": "TADA1", "gold_category": "depmap", "gold_extraction": {"cell_line": "JHU029_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "TADA1", "cell_line": "JHU029_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1788282519066408}], "total_genes_mentioned": 1}, "metadata": {"n_genes": 1, "source_db": "depmap", "gene_symbols": ["TADA1"], "cell_line": "JHU029_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0497", "task": "ge-l2", "split": "fewshot", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SNU1041_UPPER_AERODIGESTIVE_TRACT (Head and Neck) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- BTBD18: gene effect = 0.154, dependency probability = 0.003 \u2192 classified as non-essential\n- SH3BP5: gene effect = 0.076, dependency probability = 0.006 \u2192 classified as non-essential", "gold_answer": "BTBD18", "gold_category": "depmap", "gold_extraction": {"cell_line": "SNU1041_UPPER_AERODIGESTIVE_TRACT", "screen_type": "CRISPR", "genes": [{"gene_name": "BTBD18", "cell_line": "SNU1041_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1537025613002355}, {"gene_name": "SH3BP5", "cell_line": "SNU1041_UPPER_AERODIGESTIVE_TRACT", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0758687612821655}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["BTBD18", "SH3BP5"], "cell_line": "SNU1041_UPPER_AERODIGESTIVE_TRACT"}}
+{"question_id": "GEL2-0498", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE (Lymphoid) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- EID1: gene effect = 0.189, dependency probability = 0.006 \u2192 classified as non-essential\n- KCTD7: gene effect = -0.114, dependency probability = 0.064 \u2192 classified as non-essential", "gold_answer": "EID1", "gold_category": "depmap", "gold_extraction": {"cell_line": "JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_type": "CRISPR", "genes": [{"gene_name": "EID1", "cell_line": "JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.1888635304522133}, {"gene_name": "KCTD7", "cell_line": "JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.1138396043569991}], "total_genes_mentioned": 2}, "metadata": {"n_genes": 2, "source_db": "depmap", "gene_symbols": ["EID1", "KCTD7"], "cell_line": "JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE"}}
+{"question_id": "GEL2-0499", "task": "ge-l2", "split": "test", "difficulty": "medium", "context_text": "A genome-wide CRISPR-Cas9 knockout screen was performed in SKMG1_CENTRAL_NERVOUS_SYSTEM (CNS/Brain) as part of the Cancer Dependency Map (DepMap) project.\n\nGene-level essentiality results (Chronos algorithm):\n- CCDC97: gene effect = -0.077, dependency probability = 0.057 \u2192 classified as non-essential\n- ENHO: gene effect = -0.410, dependency probability = 0.424 \u2192 classified as non-essential\n- RAI14: gene effect = 0.040, dependency probability = 0.014 \u2192 classified as non-essential", "gold_answer": "CCDC97", "gold_category": "depmap", "gold_extraction": {"cell_line": "SKMG1_CENTRAL_NERVOUS_SYSTEM", "screen_type": "CRISPR", "genes": [{"gene_name": "CCDC97", "cell_line": "SKMG1_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.076810049628303}, {"gene_name": "ENHO", "cell_line": "SKMG1_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": -0.4096269443754422}, {"gene_name": "RAI14", "cell_line": "SKMG1_CENTRAL_NERVOUS_SYSTEM", "screen_method": "CRISPR", "essentiality_status": "non-essential", "dependency_score": 0.0399431195182716}], "total_genes_mentioned": 3}, "metadata": {"n_genes": 3, "source_db": "depmap", "gene_symbols": ["CCDC97", "ENHO", "RAI14"], "cell_line": "SKMG1_CENTRAL_NERVOUS_SYSTEM"}}