"""Two-stage embedding-based prompt selection. Stage 1: For each query batch, find top-K1 most similar control prompts based on cosine similarity in embedding space. Stage 2: Map those K1 control prompts to their predicted perturbation embeddings, average, and find top-n_base_cells real perturbed prompts closest to that average. """ from __future__ import annotations import numpy as np from sklearn.metrics.pairwise import cosine_similarity def select_prompt_indices( query_embeddings: np.ndarray, batch_global_indices: np.ndarray, prompt_ctrl_embeddings: np.ndarray, predicted_pert_embeddings: np.ndarray, prompt_pert_embeddings: np.ndarray, n_base_cells: int, top_k1: int = 512, ) -> np.ndarray: """Select best prompt indices for a single query batch. Parameters ---------- query_embeddings : (N_query, D) Precomputed embeddings for all query cells. batch_global_indices : (batch_len,) Indices into query_embeddings for the current batch. prompt_ctrl_embeddings : (N_ctrl, D) Embeddings of control prompt cells. predicted_pert_embeddings : (N_ctrl, D) Embeddings of predicted perturbation cells (1-to-1 with ctrl). prompt_pert_embeddings : (N_pert, D) Embeddings of real perturbed prompt cells. n_base_cells : int Number of prompt cells to select. top_k1 : int Number of control prompts to shortlist in stage 1. Returns ------- selected_idx : (n_base_cells,) Indices into the prompt_pert AnnData for the selected prompts. """ # Mean embedding of current query batch mean_query_emb = query_embeddings[batch_global_indices].mean(axis=0, keepdims=True) # Stage 1: cosine similarity against control prompts sim_ctrl = cosine_similarity(mean_query_emb, prompt_ctrl_embeddings)[0] k1 = min(top_k1, len(sim_ctrl)) top_k1_idx = np.argpartition(sim_ctrl, -k1)[-k1:] # Stage 2: average predicted perturbation embeddings of stage-1 hits pred_emb_mean = predicted_pert_embeddings[top_k1_idx].mean(axis=0, keepdims=True) # Cosine similarity against real perturbed prompts sim_pert = cosine_similarity(pred_emb_mean, prompt_pert_embeddings)[0] n_select = min(n_base_cells, len(sim_pert)) selected_idx = np.argpartition(sim_pert, -n_select)[-n_select:] return selected_idx