Does aging in humans cause decreases in region specific aerobic glycolysis and changes in brain glucose metabolism?

Answer: Not Sure Enough


Does decreased region specific aerobic glycolysis in aged humans slow aging induced changes in brain glucose metabolism?

Answer: Not Sure Enough


Does deficiency of Tetraspanin-3 result in impaired stem cell-renewal and disease propagation?

Answer: Yes


Does deficiency of Tetraspanin-3 cause improved stem cell-renewal and slow disease propagation?

Answer: No


Is delayed sleep phase disorder associated with a dominant coding variation in the core circadian clock gene CRY1?

Answer: Yes


Does deletion of αvβ8 result in a spontaneous inflammatory phenotype?

Answer: No


Does Deltex interact with eIF3f, a DUB required for Notch activation process?

Answer: Yes


Can differentiated E2f-1, -2, -3 TKO cells in the intestine exhibit apoptosis?

Answer: Not Sure Enough


Can diminished ovarian reserve be used as the sole indicator of infertility in a non-infertile population?

Answer: Yes


Is it true that distant CREs are more conserved among species?

Answer: Not Sure Enough


Do activated B cells express high levels of EBI2 during the primary early antibody response?

Answer: Not Sure Enough


Do activated B cells express low levels of EBI2 during the primary early antibody response?

Answer: Not Sure Enough


Does electromagnetic interference have any effect on Radio Frequency Identification (RFID) readability and reading distances?

Answer: Not Sure Enough


Have electrophysiological changes in motor neurons been observed in patients with amyotrophic lateral sclerosis?

Answer: Yes


Does Esrrb associate with BAF and Mbd3/NURD complexes?

Answer: Not Sure Enough


Is excess nitric oxide responsible for vasospasm?

Answer: No


Is the expression of MSX2 induced 3 hours after the addition of BMP4, which occurs later than T and CDX2?

Answer: Not Sure Enough


Is it true that falsified artemisinin family drugs with no active ingredient are generally safe?

Answer: No


Can falsified artemisinin family drugs with no active ingredient be life-threatening?

Answer: Yes


Do female carriers of the Apolipoprotein E4 (APOE4) allele have a reduced risk for Alzheimer's disease?

Answer: No


Does Fibroblast growth factor 21 increase vulnerability to atherosclerosis by modulating adiponectin and SREBP2 levels?

Answer: No


Do 40-150 out of every 1,000 children with cerebral palsy have a history of being premature or underweight at birth?

Answer: Not Sure Enough


Answer: Not Sure Enough


Is funding the elimination of sporadic malaria cases a less efficient use of healthcare resources than treating other health priorities in a setting with limited resources?

Answer: Yes


Does G-CSF prevent MDSCs from infiltrating tumors?

Answer: No


Does GEF-H1 activate RhoA in response to extracellular signal-regulated kinase activation?

Answer: Yes


Can gene expression be highly variable across genetically identical cells?

Answer: Yes


Are genes regulated by Esrrb transcription factor affected by Mbd3 function?

Answer: Not Sure Enough


Does genetic deficiency of mast cells result in greater weight gain in a mouse model of diet-induced obesity?

Answer: No


Does genetic deletion of JAM-A decrease gut permeability?

Answer: No


Is the difference in genome size of rice explained by expansion of LTR retrotransposons?

Answer: Yes


Does genomic instability in leukemia cells result from a decrease in reactive oxygen species from oncogene activation?

Answer: No


Does an increase in reactive oxygen species from oncogene activation result in genomic instability in leukemia cells?

Answer: Yes


Is ginger hazardous to mechanically ventilated patients due to their susceptibility to mucosal lesions and ulcers?

Answer: Not Sure Enough


Is ginger safe for mechanically ventilated patients?

Answer: Not Sure Enough


Does restricting glucose to 0.05% increase RLS by 20-40% in S. cerevisiae?

Answer: Not Sure Enough


Are Golli-deficient T-cells dormant in initial clonal expansion?

Answer: No


Are Golli-deficient T-cells hyper proliferative in initial clonal expansion?

Answer: Yes


Does having a main partner increase survival rates in HIV patients?

Answer: Yes


Does having a main partner lower survival rates in HIV patients?

Answer: No


Are hematopoietic progenitor cells susceptible to HIV-1 infection ex vivo?

Answer: Not Sure Enough


Answer: Not Sure Enough


Does high cardiopulmonary fitness cause a decreased mortality rate?

Answer: Yes


Does high levels of copeptin increase the risk of diabetes?

Answer: Yes


Is higher initial mortality associated with antidepressant use?

Answer: Yes


Can hypertension be accurately diagnosed with ambulatory blood pressure monitoring?

Answer: Yes


Does hypoglycemia decrease the risk of dementia?

Answer: No


Does IFI16 promote phosphorylation and translocation of STING, resulting in increased activation of STING induced by cGAMP?

Answer: Yes


Does IL-10 production by monocytes encourage CD4 + T cell response?

Answer: No


Does immune complex triggered cell death lead to extracellular release of oxidized mitochondrial DNA?

Answer: Not Sure Enough


Does immune complex-triggered cell death slow down extracellular release of nuclear DNA?

Answer: Not Sure Enough


Does impaired RhoA activity cause megakaryocytes to exit mitosis without complete karyokinesis?

Answer: Yes


Does blocking Wingless-Int-1 secretion from mouse embryonic stem cells encourage self-renewal of the mouse embryonic stem cells in a naive state?

Answer: No


Are the dominant population of T cells in pediatric tissues naive T cells emigrants from the thymus?

Answer: Yes


Does drowning affect boys at a higher rate than girls in the UK?

Answer: Not Sure Enough


Has the incidence of sepsis changed between 2009-2014?

Answer: Yes


Is increased expression of Bcl2 important for the maintenance and progression of tumors?

Answer: Yes


Does induction of urokinase receptor signaling in podocytes have any effect on foot process effacement and proteinuria?

Answer: No


Is infection of human T-cell lymphotropic virus type 1 most frequent in individuals of European origin?

Answer: Not Sure Enough


Does inhibiting HDAC6 decrease survival of mice with ARID1A mutated tumors?

Answer: No


Does inhibiting glucose-6-phosphate dehydrogenase impair lipogenesis by reactivating LKB1-AMPK signaling?

Answer: Yes


Do falciparum parasites form agglomerates of infected cells inside the body to avoid spleen clearance?

Answer: Not Sure Enough


Does Intramembrane cleavage by SPP facilitate degradation of proteins with a complex membrane orientation?

Answer: Yes


Does KLF4 prevent VSMCs from acquiring genetic characteristics of other cell types within atherosclerotic lesions?

Answer: No


Answer: Not Sure Enough


Does LSD1 play a role in transcriptional activation?

Answer: Yes


Do lice attenuated SIV vaccines induce a weaker antigen-specific T cell response in lymph node cells?

Answer: No


Does lithium damage function in the SCA1 mouse model?

Answer: No


Is it true that Lmna knock-in models are unsuitable for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS)?

Answer: Not Sure Enough


Does the localization of PIN1 in the Arabidopsis embryo require VPS9a?

Answer: Not Sure Enough


Does long-term use of statins decrease the risk of gallstones followed by cholecystectomy?

Answer: Yes


Does long-term use of statins increase the risk of gallstones followed by cholecystectomy?

Answer: No


Do low saturated fat diets have adverse effects on growth or development of infants?

Answer: Yes


Does low saturated fat diets have adverse effects on growth or development of infants?

Answer: No


Do lupus-prone mice infected with curliproducing bacteria have lower autoantibody titers compared to controls?

Answer: No


Is JIB 04 primarily active against KDM5A, a lysine histone demethylase inhibitor?

Answer: Not Sure Enough


Does MUC1-C inhibit the NF-κB p65 signaling pathway by interacting with IκB kinase ß?

Answer: No


Does Major vault protein (MVP) function to decrease tumor aggression?

Answer: No


Does malaria have a low vectorial capacity?

Answer: Not Sure Enough


Did Medicare beneficiaries experience a median delay of 2.4 days between lung cancer diagnosis and initiation of chemotherapy in 2006?

Answer: No


Do metastases have genomic aberrations different from those of the primary tumor?

Answer: Yes


Do microarray results from cultured mixtures of serotypes correlate well with microarray results from uncultured mixtures?

Answer: Not Sure Enough


Are mitochondria involved in processes related to cell signaling?

Answer: No


Do mitochondria play a major role in calcium homeostasis?

Answer: Yes


Does monoclonal antibody targeting of N-cadherin promote growth?

Answer: No


Do motor neurons from patients with amyotrophic lateral sclerosis have electrophysiological changes relative to healthy patients?

Answer: Yes


Do myelin sheaths play an important role in trophic support?

Answer: Yes


Does the N348I mutation decrease resistance to zidovudine (AZT)?

Answer: No


Does NAC encourage the generation of angiotensin-converting enzyme?

Answer: Not Sure Enough


Does NAC stabilize NO to reduce the effect of contrast agents on renal functions?

Answer: Not Sure Enough


Is NLRP12 a positive regulator of T-cell receptor activation?

Answer: No


Is NR5A2 important in bile acid homeostasis in humans?

Answer: Not Sure Enough


Does the penetration depth decrease in fiberoptic confocal microscopy with near-infrared wavelengths?

Answer: No


Does near-infrared wavelengths increase penetration depth in fiberoptic confocal microscopy?

Answer: Yes


Is it true that ninety percent (90%) of kidney cancers in the UK are attributable to excess weight?

Answer: No


Has a strong relationship been found with Pioglitazone use and increased risk for pancreatic cancer?

Answer: No


Did normal granulomas form in the absence of TNF-␣ despite increased bacterial growth?

Answer: Yes


Can Notch signalling occur between tumor cells and stromal cells?

Answer: Yes


Does Nrde-3 facilitate heritable silencing in C. elegans by transporting secondary siRNAs to the nucleus?

Answer: Yes


Answer: Yes


Answer: Yes


Answer: No


Answer: No


Are occipital activation levels correlated with auditory spatial performance in parietal regions of the brain?

Answer: Not Sure Enough


Does oral ibandronate increase the relative risk of new vertebral fractures and clinical vertebral fractures in women?

Answer: Not Sure Enough


Does oral ibandronate reduce the relative risk of new vertebral fractures and clinical vertebral fractures in women?

Answer: Not Sure Enough


Are osteocytes associated with G-CSF induced HSPC mobilization?

Answer: No


Does PEP carboxylase enhance threonine production in E. coli?

Answer: Not Sure Enough


Does PEP carboxylase suppress threonine production in E. coli?

Answer: Not Sure Enough


Do PRC1-bound plasmids sediment at a faster rate than unbound plasmids in sucrose gradients?

Answer: Not Sure Enough


Does quitting smoking reduce the risk of lung cancer by approximately 5%?

Answer: No


Does participating in six months of physical activity impair cognitive functioning?

Answer: No


Do patients in stable partnerships have a slower progression from HIV to death?

Answer: Yes


Do patients with panic anxiety show increased CSF levels of hypocretin?

Answer: Yes


Are pattern recognition receptors transcripts determinant for resistance to Plasmodium infection?

Answer: Yes


Does persister cells lead to clinical relapse in cancer patients?

Answer: Not Sure Enough


Does phosphorylation of the ATM protein regulate DNA damage-induced neuronal death?

Answer: Yes


Has a correlation been observed between physical activity levels and differences in VO2max between black and white youth?

Answer: Yes


Are Piezo1 channels sensors for cell crowding in epithelial cells?

Answer: Yes


Is PQBP1 the co-receptor of HIV-DNA to trigger cell-autonomous antiviral responses?

Answer: Yes


Does polyploidization in megakaryocytes occur in the presence of an aberrant mitosis?

Answer: Yes


Is the presence of stemloops important for reverse transcription in short interspersed nuclear elements (SINEs)?

Answer: Not Sure Enough


Is pretreatment with the CK-666 Arp2/3 inhibitor associated with lamellipodia formation?

Answer: No


Are propriospinal interneurons required for recovery from spinal cord injury?

Answer: No


Is it true that proteins from the growth cone are ubiquitinated less frequently than proteins from the cell body?

Answer: No


Does pseudoknots alter gene expression by inducing ribosomal frameshifts in viruses?

Answer: Yes


Is it true that pseudoknots are evolutionarily conserved throughout most eukaryotes?

Answer: Not Sure Enough


Does Pyridostatin delay checkpoint activation?

Answer: No


Does pyridostatin increase telomere fragility in BRCA2-deficient cells?

Answer: Yes


Do physical examinations combined with C-reactive protein values improve the predictions of radiographically verified pneumonia?

Answer: Yes


Does rapamycin accelerate aging in fruit flies?

Answer: No


Does Rapamycin treatment raise G-CSF levels?

Answer: Yes


Is the rate of hypertension in patients with type 2 diabetes mellitus similar to that of non-diabetic subjects?

Answer: No


Does replacing OCT4 and SOX2 genes with mesendoderm-related genes have the ability to reprogram human cells?

Answer: Not Sure Enough


Does risedronate reduce the risk of vertebral and non-vertebral fractures?

Answer: Yes


Do roughly 10% of women with chronic pelvic pain have no underlying pathology?

Answer: Not Sure Enough


Does roughly one in twenty UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues?

Answer: Not Sure Enough


Does roughly one in two thousand UK citizens harbor variant Creutzfeldt-Jakob disease prions in lymphoid tissues?

Answer: Not Sure Enough


Does S-nitrosylated GAPDH physiologically transnitrosylate DNA-activated protein kinase?

Answer: Yes


Does S-nitrosylated GAPDH physiologically transnitrosylate target nuclear proteins?

Answer: Yes


Does SOD1 integrate oxygen and glucose signals to repress cellular respiration?

Answer: Yes


Do serotonin receptors have any effect on depression?

Answer: No


Do serotonin receptors play a role in depression?

Answer: Yes


Does the use of antidepressants decrease the risk of stroke?

Answer: No


Does the use of antidepressants increase the risk of mortality in postmenopausal women due to side effects?

Answer: Yes


Does the use of antidepressants increase the risk of myocardial infarction due to associated side effects?

Answer: Not Sure Enough


Are Somatic missense mutations in NT5C2 associated with relapse of acute lymphoblastic leukemia?

Answer: Yes


Are somatic missense mutations in NT5C2 associated with relapse of acute lymphoblastic leukemia?

Answer: No


Have some countries achieved the goal of eradicating malaria?

Answer: Yes


Is it true that some signals for alternative polyadenylation sites are encoded in transposable elements?

Answer: Yes


Is suboptimal nutrition a leading cause of chronic disease?

Answer: Yes


Are supracellular actomyosin structures found at boundaries in Drosophila wing imaginal discs?

Answer: Yes


Is sustained transmission of Avian influenza A observed between humans?

Answer: Yes


Are sweet taste receptors on the tongue activated by between 300 and 1000 mM glucose?

Answer: Not Sure Enough


Does synaptic activity enhance local synthesis of brain derived neurotrophic factor from postsynaptic dendrites?

Answer: Yes


Does synaptic activity impair local release of brain derived neurotrophic factor from postsynaptic dendrites?

Answer: No


Does synaptic activity impair local synthesis of brain derived neurotrophic factor from postsynaptic dendrites?

Answer: No


Are T cell receptor/CD3 microdomains necessary for the induction of the immunological synapse?

Answer: No


Do T regulatory cells (tTregs) without αvβ8 have the ability to suppress pathogenic T-cell responses during active inflammation?

Answer: Yes


Is taking anti-depressants associated with an increase in the Aβ level in the brain of experimental animals?

Answer: No


Do Tet enzymes activate microRNAs that are required for iPSC derivation?

Answer: Yes


Is the 7.5% 10-year Atherosclerotic cardiovascular disease risk threshold strategy for initiating statin therapy more cost-effective than the 10% risk threshold strategy?

Answer: No


Answer: Yes


Does the C-type lectin receptor (CLEC-2) rearrange the actin cytoskeleton in dendritic cells to suppress motility along stromal surfaces?

Answer: No


Did the DESMOND program achieve a significant impact on lifestyle outcomes?

Answer: No


Does the DESMOND program significantly improve biochemical outcomes?

Answer: No


Does the H3.3K36me3 histone reader protein ZMYND11 have a higher binding affinity if G34R/V is mutated?

Answer: Not Sure Enough


Does the PDPN gene activate the C-type lectin receptor (CLEC-2)?

Answer: Yes


Are the actual sequences of CP-1 and CR-5 regions evolutionarily conserved throughout most eukaryotes?

Answer: Not Sure Enough


Does the appearance of brown-like or beige cells mainly occur in subcutaneous fat, not visceral fat?

Answer: Not Sure Enough


Does the balance between F- and G-actin regulate the orientation of neuronal migration in the developing cerebral cortex?

Answer: Yes


Is the binding orientation of the ML-SA1 activator at hTRPML2 similar to the binding orientation of the ML-SA1 activator at hTRPML1?

Answer: Not Sure Enough


Does the center of the granuloma in an immune cell induce an anti-inflammatory immune response?

Answer: No


Is the first MBT repeat necessary for the interaction between the 4MBT domain of Drosophila's Sfmbt and mammalian L3MBTL2 with the spacer region of Drosophila's Pleiohomeotic or its human ortholog YY1?

Answer: Not Sure Enough


Is the innate immune response efficient at removing small numbers of parasites?

Answer: Yes


Does the minor G allele of FOXO3 suppress IL-10?

Answer: No


Does the myocardial cell lineage develop from cardiac progenitors of mesodermal origin?

Answer: Yes


Does the number of Ndc80 complexes vary with cell cycle timing?

Answer: Not Sure Enough


Does the number of unfertilized oocytes in mated hermaphrodites decrease with age?

Answer: Not Sure Enough


Does the periosteum consist of two layers, with the inner layer having monocyte/macrophage-lineage cells, osteoblastic cells, and abundant periostin, and the outer layer consisting of collagens, blood vessels, and nerve endings?

Answer: Not Sure Enough


Does phosphorylation of Drp1 at the S616 site inhibit its mitochondrial translocation when activated by Ca2+/calmodulin-dependent kinase II (CaMKII)?

Answer: No


Does the phosphorylation of Drp1 at S616 site promote its mitochondrial translocation when activated by Ca 2+ /calmodulin-dependent kinase II (CaMKII)?

Answer: Yes


Is the proportion of people with visual difficulty two times higher in high-income countries than in low-income countries?

Answer: Not Sure Enough


Are the ring complexes of chromosomes in C. elegans oocytes built in discrete layers?

Answer: Not Sure Enough


Does the tissue surrounding a granuloma in an immune cell induce an inflammatory immune response?

Answer: No


Does receiving accelerated approval result in a higher frequency of post-marketing safety events for therapeutics?

Answer: Yes


Are there four spatial channels in each hemifield of the auditory cortex of cats?

Answer: No


Is it true that there are no known genetic variants associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients?

Answer: No


Is there a neuroprotective effect of Trpm4 inhibition in mice and rats?

Answer: Yes


Is there any relation between lupus erythematosus and cardiovascular disease?

Answer: No


Do thigh-length graduated compression stockings (GCS) reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke?

Answer: No


Does thoracic aortic aneurysm affect 70-100 individuals per 100,000 people per year?

Answer: No


Does transcription factor EB prevent transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus?

Answer: No


Does transient exposure to IFN-γ result in long-lasting inflammatory responses in cancer cells due to the retention of IFN-γ on the cell surface?

Answer: Not Sure Enough


Are transplanted human glial cells capable of differentiation within the host animal?

Answer: No


Can transplanted human glial progenitor cells form a neural network with host animals' neurons?

Answer: Yes


Is tuberculosis incidence correlated with residential crowding in the UK?

Answer: Yes


Does tuberculosis-induced granulomas express immune system protein signatures that are similar to those of the surrounding tissue?

Answer: No


Does Ultrafine Anaphase Bridges represent a mechanism for resolving partially-replicated stretches of DNA?

Answer: Yes


Does chemical mutagenesis have the capability to induce point mutations that are not typically modeled by insertional mutagenesis approaches?

Answer: Not Sure Enough


Does V-9302 cause antitumor responses by increasing cell death and oxidative stress?

Answer: Yes


Is vaccinating the gastrointestinal tract effective in protecting rectal and vaginal mucosa?

Answer: No


Did verbal autopsy (VA) perform well in distinguishing between different injury categories in the elderly population?

Answer: Yes


Does vitamin D deficiency have any effect on the term of child delivery?

Answer: No


Does whole brain radiotherapy reduce the occurrence of new brain metastases?

Answer: Yes


Is c-MYC important for maintaining the pluripotent state of pluripotent stem cells?

Answer: Yes


Does mTORC2 inhibit the xCT antiporter through phosphorylation?

Answer: Yes


Is p16INK4A accumulation encoded by CDKN2A?

Answer: Not Sure Enough


Does p53 control autophagy through the AMPK/mTOR-dependent pathway?

Answer: Not Sure Enough


Answer: Not Sure Enough


Do 0-dimensional biomaterials show inductive properties?

Answer: Not Sure Enough


Does the 1,000 genomes project enable the mapping of genetic sequence variation containing rare variants with greater penetrance effects than common variants?

Answer: Yes


Do 1 in 2000 people in the UK have abnormal PrP positivity?

Answer: Yes


Is 5% of perinatal mortality due to low birth weight?

Answer: Not Sure Enough


Does a deficiency of vitamin B12 increase blood levels of homocysteine?

Answer: Not Sure Enough


Does a high microerythrocyte count increase the susceptibility to severe anemia in individuals with homozygous alpha (+)-thalassemia trait?

Answer: No


Is it true that 1,000 people in the UK are asymptomatic carriers of vCJD infection?

Answer: No


Does ADAR1 bind to Dicer to cleave pre-miRNA?

Answer: Yes


Answer: Yes


Is ALDH1 expression associated with better breast cancer outcomes?

Answer: No


Is ALDH1 expression associated with poorer prognosis in breast cancer?

Answer: Yes


Does the activation of AMP-activated protein kinase (AMPK) increase inflammation-related fibrosis in the lungs?

Answer: No


Does the expression of APOE4 in iPSC-derived neurons increase AlphaBeta production and tau phosphorylation, causing GABA neuron degeneration?

Answer: Yes


Does the expression of APOE4 in iPSC-derived neurons increase AlphaBeta production and tau phosphorylation, and delay GABA neuron degeneration?

Answer: No


Does activation of PPM1D suppress p53 function?

Answer: Yes


Are activator-inhibitor pairs provided dorsally by Admp/chordin?

Answer: Not Sure Enough


Does active H. pylori urease have a polymeric structure compromising two subunits, UreA and UreB?

Answer: Not Sure Enough


Is albendazole used to treat lymphatic filariasis?

Answer: Not Sure Enough


Does Alizarin form hydrogen bonds with residues involved in PGAM1 substrate binding?

Answer: Not Sure Enough


Do all hematopoietic stem cells segregate their chromosomes randomly?

Answer: Yes


Are angiotensin converting enzyme inhibitors associated with increased risk for functional renal insufficiency?

Answer: Yes


Can anthrax spores be disposed of easily after they are dispersed?

Answer: No


Does antibiotic usage cause changes in the gut microbiome that decrease resistance to Clostridium difficile?

Answer: Yes


Does antiretroviral therapy reduce rates of tuberculosis across a broad range of CD4 strata?

Answer: Yes


Is arginine 90 in p150n important for interaction with EB1?

Answer: Not Sure Enough


Do arterioles have a larger lumen diameter than venules?

Answer: Not Sure Enough


Is it true that articles published in open access format are less likely to be cited than traditional journals?

Answer: No


Are articles published in open access format more likely to be cited than traditional journals?

Answer: Yes


Does aspirin inhibit the production of PGE2?

Answer: Not Sure Enough


Is the assembly of invadopodia triggered by focal generation of phosphatidylinositol-3,4-biphosphate and the activation of the nonreceptor tyrosine kinase Src?

Answer: Yes


Does asymptomatic visual impairment screening in elderly populations lead to improved vision?

Answer: Yes


Is auditory entrainment strengthened when people see congruent visual and auditory information?

Answer: Yes


Does autologous transplantation of mesenchymal stem cells cause a higher rate of opportunistic infections compared to induction therapy with anti-interleukin-2 receptor antibodies?

Answer: No


Does autologous transplantation of mesenchymal stem cells cause fewer opportunistic infections than induction therapy with anti-interleukin-2 receptor antibodies?

Answer: Yes


Does autologous transplantation of mesenchymal stem cells have lower rates of rejection than induction therapy with anti-interleukin-2 receptor antibodies?

Answer: Yes


Does autophagy decline in aged organisms?

Answer: Yes


Does bariatric surgery have a positive impact on mental health?

Answer: Yes


Do basophils counteract disease development in patients with systemic lupus erythematosus (SLE)?

Answer: No


Is birth-weight positively associated with breast cancer?

Answer: Yes


Does blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 result in increased TDP-43-induced neuronal loss?

Answer: No


Do bone marrow cells contribute to adult macrophage compartments?

Answer: No


Is breast cancer development solely determined by genetic factors?

Answer: No


Answer: Not Sure Enough


Answer: Yes


Is CR associated with higher methylation age?

Answer: No


Is CRP predictive of postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery?

Answer: Not Sure Enough


Does CX3CR1 on the Th2 cells impair T cell survival?

Answer: No


Does CX3CR1 on Th2 cells promote T cell survival?

Answer: Yes


Does CX3CR1 on the Th2 cells promote airway inflammation?

Answer: Yes


Does CX3CR1 on Th2 cells suppress airway inflammation?

Answer: No


Do carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink less than non-carriers?

Answer: Yes


Are cataract and trachoma the primary cause of blindness in Southern Sudan?

Answer: Not Sure Enough


Does cell autonomous sex determination occur in Galliformes' somatic cells?

Answer: No


Does cell autonomous sex determination occur in somatic cells in Passeriformes?

Answer: Yes


Does Bacillus subtilis have a defect in sporulation efficiency when cells lack clpC?

Answer: Not Sure Enough


Does the restriction of methionine in cells result in the activation of miRNAs?

Answer: Not Sure Enough


Does cellular aging closely link to an older appearance?

Answer: Yes


Does chenodeoxycholic acid treatment increase whole-body energy expenditure?

Answer: Yes


Does chenodeoxycholic acid treatment reduce whole-body energy expenditure?

Answer: No


Does chronic aerobic exercise alter endothelial function to improve vasodilating mechanisms mediated by NO?

Answer: Yes


Does cold exposure increase BAT recruitment?

Answer: Not Sure Enough


Does cold exposure reduce BAT recruitment?

Answer: Not Sure Enough


Does combining nicotine replacement therapies with varenicline or bupropion lead to higher long-term abstinence rates at 52 weeks than varenicline monotherapy?

Answer: No


Is combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors effective in treating KRAS mutant tumors?

Answer: Yes


Does the genome of Commelina yellow mottle virus consist of 7489 base pairs?

Answer: Yes


Are crossover hot spots found within gene promoters in Saccharomyces cerevisiae?

Answer: Not Sure Enough


Is crosstalk between dendritic cells (DCs) and innate lymphoid cells (ILCs) important in regulating intestinal homeostasis?

Answer: Yes


Is cytochrome c released from the mitochondrial intermembrane space to cytosol during apoptosis?

Answer: Yes


Do cytosolic proteins bind to iron-responsive elements on mRNAs coding for proteins involved in iron uptake?

Answer: Not Sure Enough


Is DMRT1 a sex-determining gene that is epigenetically regulated by the MHM region?

Answer: Not Sure Enough


Does de novo assembly of sequence data have more specific contigs than unassembled sequence data?

Answer: Not Sure Enough


Does deamination of cytidine to uridine on the minus strand of viral DNA result in catastrophic G-to-A mutations in the viral genome?

Answer: Yes


Does deleting Raptor reduce G-CSF levels?

Answer: Not Sure Enough


Does the deletion of αvβ8 result in a spontaneous inflammatory phenotype?

Answer: Yes


Does dexamethasone decrease the risk of postoperative bleeding?

Answer: No


Do diabetic patients with acute coronary syndrome experience an increased risk for bleeding events in the short-term and long-term?

Answer: Yes


Does discrimination between the initiator and elongation tRNAs depend on the translation initiation factor IF3?

Answer: Not Sure Enough


Does downregulation and mislocalization of Scribble prevent cell transformation and mammary tumorigenesis?

Answer: Not Sure Enough


Do activated B cells migrate toward the inner- and outer paracortical areas during the primary early antibody response, where oxysterol accumulation is generated by stromal cells?

Answer: Not Sure Enough


Does enhanced early production of inflammatory chemokines improve viral control in the lung?

Answer: Yes


Is the epidemiological disease burden from noncommunicable diseases more prevalent in low economic settings?

Answer: Not Sure Enough


Do Epigenetic modulating agents (EMAs) modulate antitumor immune response in a cancer model system?

Answer: Yes


Is it true that errors in peripheral IV drug administration are most common during bolus administration and multiple-step medicine preparations?

Answer: Yes


Does ethanol stress decrease the expression of IBP in bacteria?

Answer: Not Sure Enough


Is exposure to fine particulate air pollution related to anxiety prevalence?

Answer: Yes


Does febrile seizures increase the threshold for the development of epilepsy?

Answer: Not Sure Enough


Does febrile seizures reduce the threshold for development of epilepsy?

Answer: Not Sure Enough


Do female carriers of the Apolipoprotein E4 (APOE4) allele have an increased risk for dementia?

Answer: Yes


Do flexible molecules experience greater steric hindrance in the tumor microenvironment than rigid molecules?

Answer: Not Sure Enough


Is FoxO3a activation in neuronal death mediated by reactive oxygen species (ROS)?

Answer: Yes


Is it true that free histones are degraded by a Rad53-dependent mechanism once DNA has been replicated?

Answer: Yes


Is it true that the functional consequences of genomic alterations caused by Myelodysplastic syndrome (MDS) are poorly understood because an animal model is lacking?

Answer: Not Sure Enough


Does Fz/PCP-dependent Pk localize to the anterior membrane of neuroectoderm cells during zebrafish neuralation?

Answer: Not Sure Enough


Does Fz/PCP-dependent Pk localize to the anterior membrane of notochord cells during zebrafish neuralation?

Answer: Not Sure Enough


Is GATA-3 important for hematopoietic stem cell (HSC) function?

Answer: Yes


Does gene expression vary appreciably across genetically identical cells?

Answer: No


Is glycolysis one of the primary glycometabolic pathways in cells?

Answer: Yes


Do Golli-deficient T-cells prefer to differentiate into an anergic phenotype in the adaptive immune response when there are increased levels of Ca2+ in the cytosol?

Answer: Not Sure Enough


Can HNF4A mutations cause diabetes in mutant carriers by the age of 14 years?

Answer: Not Sure Enough


Are headaches correlated with cognitive impairment?

Answer: Yes


Is healthcare delivery efficiency impaired by improving structural, logistical, and interpersonal elements in crowded delivery centers?

Answer: Not Sure Enough


Do helminths interfere with the immune system's control of macrophages activated by IL-4 and favor Mycobacterium tuberculosis replication?

Answer: Not Sure Enough


Does Hematopoietic Stem Cell purification reach a purity rate of up to 50%?

Answer: Not Sure Enough


Does high cardiopulmonary fitness cause increased mortality rate?

Answer: No


Is it necessary to consume high levels of dietary calcium to prevent secondary hyperparathyroidism in individuals with 25(OH)D levels above 75 nmol/liter?

Answer: Not Sure Enough


Does high levels of CRP reduce the risk of exacerbations in chronic obstructive pulmonary disease (COPD)?

Answer: No


Do high levels of copeptin decrease the risk of diabetes?

Answer: Not Sure Enough


Does the dosage of high-sensitivity cardiac troponin T (HSCT-T) have diagnostic value if the onset of symptoms occurs less than 3 hours before acute myocardial injury (AMI)?

Answer: Yes


Is histone demethylase recruitment and a transient decrease in histone methylation necessary for ligand-dependent induction of transcription by nuclear receptors?

Answer: Yes


Does homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) prevent oxidative stress?

Answer: Not Sure Enough


Do HAM/TSP patients produce Immunoglobulin G (IgG) antibodies that cross-react with an immunodominant epitope in Tax?

Answer: Yes


Does hyperfibrinogenemia decrease rates of femoropopliteal bypass thrombosis?

Answer: No


Does hyperfibrinogenemia increase rates of femoropopliteal bypass thrombosis?

Answer: Yes


Is hypertension frequently observed in type 1 diabetes patients?

Answer: Not Sure Enough


Do hypocretin neurons induce a panic-prone state in rats?

Answer: Yes


Does hypoglycemia increase the risk of dementia?

Answer: Yes


Is hypothalamic glutamate neurotransmission crucial to energy balance?

Answer: Yes


Does IFIT1 restrict viral replication by sequestrating mis-capped viral RNAs?

Answer: Not Sure Enough


Does IRG1 have antiviral effects against neurotropic viruses?

Answer: Yes


Does ITAM phosphorylation prevent the transfer of the TCR signal from the echo-domain to the cytoplasmic tail of the TCR?

Answer: Not Sure Enough


Do IgA plasma cells that are specific for transglutaminase 2 accumulate in the duodenal mucosa when a gluten-free diet is started?

Answer: Not Sure Enough


Does immune complex-triggered cell death lead to the extracellular release of the neutrophil protein HMGB1?

Answer: Not Sure Enough


Do immune responses result in the development of inflammatory Th17 cells and anti-inflammatory iTregs?

Answer: Not Sure Enough


Are most T cells in adult tissue memory T cells?

Answer: Yes


Is whole chromosome aneuploidy common in domesticated populations of Saccharomyces cerevisiae?

Answer: Not Sure Enough


Are P. chabaudi parasites able to proliferate faster early in infection when inoculated at lower numbers than when inoculated at high numbers in mice?

Answer: Not Sure Enough


Does the loss of CSF1R facilitate MOZ-TIF2-induced leukemogenesis in mouse models?

Answer: No


Do less than ten percent of the cells with green fluorescent in transgenic mice under the control of the Sox2 promoter colocalize with cell proliferation markers?

Answer: Not Sure Enough


Does the use of ADHD medications, whether current or remote, increase the risk of serious cardiovascular events in young and middle-aged adults?

Answer: Yes


Did the incidence of heart failure decrease by 10% in women since 1979?

Answer: Yes


Have incidence rates of cervical cancer decreased?

Answer: Yes


Have incidence rates of cervical cancer increased due to nationwide screening programs based primarily on cytology to detect uterine cervical cancer?

Answer: No


Does increased microtubule acetylation repair locomotor deficits induced by LRRK2 Roc-COR domain mutation?

Answer: Yes


Does an increase in vessel density and a decrease in fibrosis reduce the efficacy of chemotherapy treatments?

Answer: No


Do individuals with low serum vitamin D concentrations have an increased risk of multiple sclerosis?

Answer: Not Sure Enough


Is infection of human T-cell lymphotropic virus type 1 most frequent in individuals of African origin?

Answer: Not Sure Enough


Does the inositol lipid 3-phosphatase PTEN convert Ptdlns(3,4)P 2 into phosphatidylinositol 4-phosphate?

Answer: Yes


Is input from mental and physical health care professionals effective at decreasing homelessness?

Answer: Not Sure Enough


Can insomnia be effectively treated with cognitive behavioral therapy?

Answer: Yes


Does insulin increase the risk of severe kidney failure?

Answer: Not Sure Enough


Does integrating classroom-based collaborative learning with web-based collaborative learning lead to subpar class performance?

Answer: Not Sure Enough


Is Ivermectin used to treat lymphatic filariasis?

Answer: Not Sure Enough


Is Ivermectin used to treat onchocerciasis?

Answer: Not Sure Enough


Does LDL cholesterol have any involvement in the development of cardiovascular disease?

Answer: No


Does the lack of clpC affect sporulation efficiency in Bacillus subtilis cells?

Answer: Not Sure Enough


Did less than 10% of Gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) have a plasma lactate level of more than 5mmol/L?

Answer: Not Sure Enough


Does leukemia associated Rho guanine nucleotide-exchange factor repress RhoA in response to SRC activation?

Answer: Not Sure Enough


Does increased leukocytes in blood increase the risk of infectious complications during red blood cell transfusion?

Answer: No


Does leuko-reduced blood reduce infectious complications in red blood cell transfusion?

Answer: Yes


Does the localization of PIN1 in the Arabidopsis embryo require VPS9a?

Answer: Not Sure Enough


Does localization of PIN1 in the roots of Arabidopsis require VPS9a?

Answer: Not Sure Enough


Does low expression of miR7a repress target genes and exert a biological function in ovaries?

Answer: Not Sure Enough


Does low expression of miR7a have a biological function in testis?

Answer: Not Sure Enough


Does low nucleosome occupancy correlate with low methylation levels across species?

Answer: No


Do lupus-prone mice infected with curli-producing bacteria have higher autoantibody titers compared to controls?

Answer: Yes


Does Ly49Q regulate membrane raft functions to direct the organization of neutrophil migration to inflammation sites?

Answer: Yes


Do Ly6C hi monocytes have a lower inflammatory capacity compared to their Ly6C lo counterparts?

Answer: Not Sure Enough


Do Ly6C hi monocytes have a lower inflammatory capacity than Ly6C lo monocytes?

Answer: No


Is lymphadenopathy observed in knockin mice that lack the SHP-2 MAPK pathway?

Answer: Yes


Do macrolides have a protective effect against myocardial infarction?

Answer: Yes


Do macrolides protect against myocardial infarction?

Answer: No


Does macropinocytosis contribute to a cell's supply of amino acids through the intracellular uptake of protein?

Answer: Yes


Can proteins in human cells be post-translationally modified at lysine residues through acetylation?

Answer: Yes


Does using Artemisinin-based combination therapy instead of nongametocytocidal drugs have a dramatic impact in reducing malaria transmission, as predicted by mathematical models?

Answer: No


Is mercaptopurine metabolized into the inactive methylmercaptopurine by thiopurine methyltransferase (TPMT)?

Answer: Not Sure Enough


Did metastatic colorectal cancer treatment with single agent fluoropyrimidines result in reduced efficacy and lower quality of life when compared to oxaliplatin-based chemotherapy in elderly patients?

Answer: Yes


Do mice that are defective for DNA polymerase I (polI) show increased sensitivity to ionizing radiation (IR)?

Answer: Not Sure Enough


Do mice that lack Interferon-γ or its receptor show high resistance to experimental autoimmune myocarditis?

Answer: No


Are mice without IFN-γ or its receptor resistant to EAM induced with α-MyHC/CFA?

Answer: Not Sure Enough


Is MicroRNA involved in the regulation of dynamic homeostasis of Neural Stem Cell (NSC) differentiation and proliferation?

Answer: Yes


Does the correlation between microarray results from culture-amplified mixtures of serotypes and microarray results from uncultured mixtures appear to be poor?

Answer: Not Sure Enough


Answer: No


Does modifying the epigenome in the brain affect the normal human aging process by affecting certain genes related to neurogenesis?

Answer: Not Sure Enough


Does targeting of N-cadherin with monoclonal antibody inhibit metastasis?

Answer: Yes


Is it true that most termination events in Okazaki fragments are sequence specific?

Answer: Yes


Do mutant mice lacking SVCT2 have greatly increased ascorbic acid levels in both brain and adrenals?

Answer: No


Are mutations in G-Beta protein GNB2 present in many cancers, resulting in loss of interaction with G-alpha subunits and concomitant activation of AKT pathway?

Answer: Not Sure Enough


Does N-terminal cleavage increase the success rate of identifying transcription start sites?

Answer: Not Sure Enough


Does N-terminal cleavage reduce the success in identifying transcription start sites?

Answer: Not Sure Enough


Do N348I mutations cause resistance to zidovudine (AZT)?

Answer: Yes


Does NF2 (Merlin) activate LATS1/2 kinases to cause phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila?

Answer: Not Sure Enough


Does NF2 (Merlin) prevent phosphorylation and subsequent cytoplasmic sequestration of YAP in Drosophila?

Answer: Not Sure Enough


Does NFAT4 activation require IP3R-mediated Ca2+ mobilization?

Answer: Yes


Can NOX2-independent pathways generate peroxynitrite by reacting with nitrogen intermediates?

Answer: Not Sure Enough


Is NR5A2 important in the development of endometrial tissues?

Answer: Yes


Can nanoparticles be targeted against specific cell types by incorporating aptamers into lipid nanoparticles?

Answer: Yes


Are neutrophil extracellular traps (NETs) released by ANCA-stimulated neutrophils?

Answer: Yes


Do new drugs for tuberculosis penetrate the necrotic portion of a tuberculosis lesion in high concentrations?

Answer: No


Should non-invasive ventilation use be decreased if there is inadequate response to conventional treatment?

Answer: No


Does the normal expression of RUNX1 have tumor-promoting effects?

Answer: No


Answer: Not Sure Enough


Is obesity determined solely by environmental factors?

Answer: No


Do IncRNAs occupying ribosomes create functional peptides?

Answer: No


Does the occupancy of ribosomes by lncRNAs mirror 5' UTRs?

Answer: Yes


Do omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegetarians?

Answer: No


Does only a minority of cells survive development after differentiation into stress-resistant spores?

Answer: Not Sure Enough


Does PD-1 triggering on monocytes reduce IL-10 production by monocytes?

Answer: No


Does PDPN activate the C-type lectin receptor to rearrange the actin cytoskeleton in dendritic cells and promote efficient motility along stromal surfaces?

Answer: Yes


Does PGE 2 alter the expression of tumor suppressing and DNA repair genes to promote intestinal tumor growth?

Answer: Not Sure Enough


Does PKG-la play an essential role in the expression of pain hypersensitivity in PGK-la knockout mice?

Answer: Yes


Are PPAR-RXRs inhibited by PPAR ligands?

Answer: Not Sure Enough


Can PPAR-RXRs be activated by PPAR ligands?

Answer: Not Sure Enough


Does participating in six months of physical activity improve cognitive functioning?

Answer: Yes


Do patients in stable partnerships have a faster progression from HIV to AIDS?

Answer: No


Is peroxynitrite necessary for nitration of TCR/CD8?

Answer: Yes


Does pleiotropic coupling of GLP-1R to intracellular effectors promote distinct profiles of cellular signaling?

Answer: Not Sure Enough


Are podocytes motile and do they migrate in the presence of injury?

Answer: Yes


Does Polymeal nutrition reduce cardiovascular mortality?

Answer: Yes


Does pretreatment with the Arp2/3 inhibitor CK-666 affect lamellipodia formation?

Answer: Yes


Does primary cervical cancer screening with HPV detection have higher longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2?

Answer: Yes


Do primary pro-inflammatory cytokines induce secondary pro- and anti-inflammatory mediators?

Answer: Not Sure Enough


Are proteins synthesized at the growth cone ubiquitinated at a higher rate than proteins from the cell body?

Answer: Yes


Does the pseudogene PTENP1 regulate the expression of PTEN by functioning as an miRNA decoy?

Answer: Yes


Does pyridostatin destabilize the G-quadruplex in the telomeric region?

Answer: No


Does radioiodine treatment reduce the thyroid volume of non-toxic multinodular goitre?

Answer: Yes


Does rapamycin decrease the concentration of triacylglycerols in fruit flies?

Answer: Not Sure Enough


Do rapid phosphotransfer rates govern fidelity in two component systems?

Answer: Yes


Does up-regulation of interferon-induced genes and higher basal expression help increase the survival of granule cell neurons infected with West Nile virus?

Answer: Yes


Does the rapid up-regulation and higher basal expression of interferon-induced genes reduce survival of granule cell neurons that are infected by West Nile virus?

Answer: No


Do recurrent mutations occur frequently within CTCF anchor sites adjacent to oncogenes?

Answer: Yes


Is reduced responsiveness to interleukin-2 in regulatory T cells associated with greater resistance to autoimmune diseases such as Type 1 Diabetes?

Answer: No


Does the replacement of histone H2A with H2A.Z slow down gene activation in yeasts by stabilizing +1 nucleosomes?

Answer: No


Do ribosomopathies have a low degree of cell and tissue specific pathology?

Answer: No


Does S-nitrosylated GAPDH physiologically transnitrosylate histone deacetylases?

Answer: Yes


Does Sildenafil improve erectile function in men who experience sexual dysfunction as a result of the use of SSRI antidepressants?

Answer: Yes


Is silencing of Bcl2 important for the maintenance and progression of tumors?

Answer: No


Does the engagement of Smc5/6 drive the activation of SUMO E3 ligase Mms21 through ATP-dependent remodeling?

Answer: Yes


Answer: Not Sure Enough


Answer: Not Sure Enough


Do stroke patients with prior use of direct oral anticoagulants have a lower risk of in-hospital mortality than stroke patients with prior use of warfarin?

Answer: Yes


Do subcutaneous fat depots undergo extensive browning processes after cold exposure?

Answer: Yes


Is suboptimal nutrition predictive of chronic disease?

Answer: No


Does synaptic activity enhance local release of brain derived neurotrophic factor from postsynaptic dendrites?

Answer: Yes


Are T regulatory cells (tTregs) without αvβ8 better at suppressing pathogenic T-cell responses during active inflammation?

Answer: No


Are TCR/CD3 microdomains required to induce the immunologic synapse for activating T cells?

Answer: Yes


Is TNFAIP3 a tumor suppressor in glioblastoma?

Answer: No


Does taking 400mg of α-tocopheryl acetate help to prevent prostate cancer?

Answer: No


Did taxation of sugar-sweetened beverages have any effect on the incidence rate of type II diabetes in India?

Answer: No


Do teaching hospitals provide better care than non-teaching hospitals?

Answer: Yes


Is Tetraspanin-3 a causative factor in the development of acute myelogenous leukemia?

Answer: Yes


Is the DdrB protein from Deinococcus radiodurans an alternative SSB?

Answer: Yes


Does the PPR MDA5 have two N-terminal CARD domains?

Answer: Not Sure Enough


Does the PRR MDA5 have a central DExD/H RNA helices domain?

Answer: Not Sure Enough


Is the PRR MDA5 a sensor of RNA virus infection?

Answer: Yes


Can the US health care system save up to $750 million if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program?

Answer: Yes


Does the YAP1 and TEAD complex translocate into the nucleus and interact with transcription factors and DNA-binding proteins to modulate target gene transcription?

Answer: Yes


Does the amount of publicly available DNA data double every 10 years?

Answer: Not Sure Enough


Is the arm density of TatAd complexes due to structural rearrangements within Class1 TatAd complexes, such as the 'charge zipper mechanism'?

Answer: Not Sure Enough


Is the availability of safe places to study effective at decreasing homelessness?

Answer: Not Sure Enough


Answer: Not Sure Enough


Were the benefits of colchicine achieved with effective widespread use of secondary prevention strategies such as high-dose statins?

Answer: Not Sure Enough


Is the binding orientation of the ML-SA1 activator at hTRPML2 different from the binding orientation of the ML-SA1 activator at hTRPML1?

Answer: Not Sure Enough


Does the center of the granuloma in an immune cell induce a pro-inflammatory immune response?

Answer: Yes


Is the combination of H3K4me3 and H3K79me2 found in quiescent hair follicle stem cells?

Answer: Not Sure Enough


Does the composition of myosin-II isoform switch from the polarizable B isoform to the more homogenous A isoform during hematopoietic differentiation?

Answer: Not Sure Enough


Does the deregulated and prolonged activation of monocytes have deleterious effects in inflammatory diseases?

Answer: Not Sure Enough


Is the extracellular domain of TMEM27 cleaved in human beta cells?

Answer: Yes


Are the genomic aberrations found in metastases very similar to those found in the primary tumor?

Answer: No


Is the locus rs647161 associated with colorectal carcinoma?

Answer: Yes


Could the loss of TET protein functions lead to dire biological consequences, such as myeloid cancers?

Answer: Not Sure Enough


Is the minor G allele of FOXO3 related to more severe symptoms of Crohn's Disease?

Answer: No


Does the myocardial lineage develop from cardiac progenitors of mesodermal origin?

Answer: Yes


Has the one-child policy been successful in lowering population growth?

Answer: Not Sure Enough


Is the relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome dependent on the patient's genetic make-up?

Answer: Yes


Is the repair of Cas9-induced double strand breaks in human DNA error-prone?

Answer: Yes


Does the risk of breast cancer among parous women increase with placental weight of pregnancies, and is this association strongest for premenopausal breast cancer?

Answer: Yes


Is the risk of male prisoners harming themselves ten times that of female prisoners?

Answer: No


Can the severity of cardiac involvement in amyloidosis be described by the degree of transmurality of late gadolinium enhancement in MRI?

Answer: Yes


Is the single flash-evoked ERG b-wave generated by activity of ON-bipolar cells?

Answer: Not Sure Enough


Does the sliding activity of kinesin-8 protein Kip3 promote bipolar spindle assembly?

Answer: Yes


Does the tip of the inner tube of the toxic type VI secretion system (T6SS) in Escherichia coli (E. coli) carry toxic effector proteins?

Answer: Yes


Does the treatment of cancer patients with co-IR blockade cause any adverse autoimmune events?

Answer: Not Sure Enough


Does the treatment of cancer patients with co-IR blockade result in adverse autoimmune events?

Answer: Not Sure Enough


Does the ureABIEFGH gene cluster encode urease maturation proteins UreD/UreH, UreE, UreF, and UreG?

Answer: Not Sure Enough


Is the ureABIEFGH gene cluster induced by nickel (II) ion?

Answer: Not Sure Enough


Is the therapeutic use of the drug Dapsone to treat pyoderma gangrenosum based on anecdotal evidence?

Answer: Not Sure Enough


Is there an inverse relationship between hip fractures and statin use?

Answer: Yes


Is there an association between HNF4A mutations and diabetes risks?

Answer: Not Sure Enough


Did thigh-length graduated compression stockings (GCS) reduce deep vein thrombosis in patients admitted to hospital who are immobile because of acute stroke?

Answer: Yes


Does Tirasemtiv have any effect on fast-twitch muscle?

Answer: No


Do UCB T cells acquire a memory-like phenotype in recipients after they are transferred?

Answer: Not Sure Enough


Can transplanted human glial cells differentiate within the host animal?

Answer: Yes


Are transplanted human glial progenitor cells capable of forming a neural network with host animals' neurons?

Answer: No


Are tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1) pro-inflammatory cytokines that inhibit IL-6 and IL-10?

Answer: Not Sure Enough


Do UCB T cells maintain high TCR diversity after transplantation?

Answer: Yes


Do UCB T cells reduce TCR diversity after transplantation?

Answer: No


Does ubiquitin ligase UBC13 generate a K63-linked polyubiquitin moiety at PCNA K164?

Answer: Yes


Does the use of ultrasound guidance increase the number of traumatic procedures during needle insertion?

Answer: No


Does up-regulation of the p53 pathway and related molecular events cause cancer resistance and result in a significantly shortened lifespan marked by senescent cells and accelerated organismal aging?

Answer: Not Sure Enough


Is upregulation of mosGCTL-1 induced upon infection with West Nile virus?

Answer: Yes


Is varenicline monotherapy more effective than combination nicotine replacement therapies with varenicline or bupropion after 12 weeks of treatment?

Answer: No


Do venules have a larger lumen diameter than arterioles?

Answer: Not Sure Enough


Do venules have a thinner or absent smooth layer compared to arterioles?

Answer: Not Sure Enough


Does vitamin D deficiency affect the term of delivery?

Answer: Yes


Is vitamin D deficiency related to birth weight?

Answer: No


Are women with a higher birth weight more likely to develop breast cancer later in life?

Answer: Yes


Does aPKCz affect glutamine metabolism and cause tumor enhancement?

Answer: No


Does cSMAC formation enhance weak ligand signalling?

Answer: Yes


Does mTORC2 regulate intracellular cysteine levels through xCT inhibition?

Answer: Yes


Is p16INK4A accumulation linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs)?

Answer: Not Sure Enough


Did Dan Orlovsky drive a 78-yard with more than 1 minute remaining in the game in a match against The Houston Texans?

Answer: Yes


Is Indus Towers one of the 10 largest mobile handset sellers in the world?

Answer: Yes


Was musician Thundercat born before October 19th 1984?

Answer: Yes


Answer: Yes


Does Martin Hope play guitar in the group Razorlight?

Answer: Yes


Was Stephen Bruner born on October 19, 1984?

Answer: Yes


Did Sammer replace Nerlinger during UEFA 2012?

Answer: Yes


Is A-Gon's real name Adrian Savin Gonzalez?

Answer: Yes


Did the Premier League announce the 2014-2015 fixtures in June 2014?

Answer: Yes


Answer: Yes


Is James Otto De Marcus' brother-in-law?

Answer: Not Sure Enough


Did the film score less than 61/100 on Metacritic with more than 9 critics?

Answer: Yes


Did it have a score of 59/100 based on 13 critics?

Answer: Yes


Does The Night Before have a rating of less than 73% based on 24 reviews?

Answer: Yes


Answer: Yes


Does The Night Before have more than 18 critics on Metacritic?

Answer: Yes


Did the film receive a rating of 67% after being reviewed by 52 critics?

Answer: Yes


Did the film have projections in more than 2,800 theatres?

Answer: Yes


Was The Night Before's rating on Rotten Tomatoes over 67% with more than 55 reviews?

Answer: Yes


Did Sony's Columbia Pictures distribute the film, and were both Good Universe and Point Grey Pictures responsible for producing it?

Answer: Yes


Answer: Yes


Is the film's rating less than 64% with more than 78 reviews?

Answer: Yes


Did critics give the film flattering reviews?

Answer: Yes


Did more than 29 people review The Night Before on Metacritic?

Answer: Yes


Did it make over $25 million in North America and over $26 million worldwide?

Answer: Yes


Does Betsy give them a lot of drugs on Christmas Eve for them to celebrate?

Answer: Not Sure Enough


Does Ethan steal the tickets to The Nutcracker Ball from a coat pocket?

Answer: Yes


Did The Night Before gross over $36 million in North America and more than $40 million globally?

Answer: Yes


Did the film make over $41.6 million in North America and over $7 million elsewhere for a total of over $48 million worldwide?

Answer: Yes


Did the film make over $42 million and over $49.5 million worldwide?

Answer: Yes


Was the release date of the soundtrack on November 12, 1994?

Answer: Yes


Was over 1.4 million copies sold in the US by early 2016?

Answer: Yes


Answer: Yes


Do Danny and Evelyn have a relationship?

Answer: Yes


Did Channing Freeman consider Ride the Lightning to be a combination of charm and power?

Answer: Yes


Was Gareth Bale sold for more than €85.5 million?

Answer: Yes


Does Shawn Kavanaugh star in Meet the Blacks?

Answer: Yes


Is Good Charlotte's sixth album going to be released in 2016?

Answer: Yes


Answer: Yes


Was Street Kings released in the United States and Canada?

Answer: Not Sure Enough


Answer: Not Sure Enough


Is the town of Pirri the only circoscrizione in the comune of Cagliari and are there around 30,000 inhabitants in the town?

Answer: Yes


Is Stripes, one of the leaders of the superhero team Justice Forever, portrayed by Jim Carrey in the film Kick-Ass 2?

Answer: Not Sure Enough


Did BBC Sport's coverage of Formula One start in 1978?

Answer: Yes


Did Max Herman write the music for the ceremony in King Abdullah Sport City?

Answer: Not Sure Enough


Is the character Kurt Weller in the TV series Blindspot a Supervisory Special Agent at the FBI?

Answer: Yes


Does Alex Henderson play Carl Jr. in Meet the Blacks?

Answer: Yes


Was The Light Between Oceans released in the United States on 2 September 2016?

Answer: Yes


Is The Light Between Oceans' approval rating more than 44% based on more than 15 reviews on Rotten Tomatoes?

Answer: Yes


Was the album Until the Hunter of the band The Warm Inventions released in 2016?

Answer: Not Sure Enough


Answer: Yes


Does Daryl Dixon become close to Rick Grimes?

Answer: Yes


Did FanMail sell under 12 million copies?

Answer: Yes


Is Civil Isolation the first song of the new album by While She Sleeps, was the album made available for pre-orders on September 12, and did the band also launch a pledge campaign for the album?

Answer: Yes


Had the album sold over 10 million copies worldwide by the year 2000?

Answer: Yes


Is a 1959 Corvette convertible released?

Answer: Not Sure Enough


Did Christina Benteke score less than ten goals for Liverpool?

Answer: Yes


Answer: Yes


Was Dario Argento's first movie The Phantom of the Opera in 1998?

Answer: Yes


Have The Isley Brothers had less than five Top 10 singles?

Answer: Yes


Did Paul, the character from the film Paul Blart: Mall Cop, faint when he was almost done with his training?

Answer: Yes


Did the members of the Good Charlotte band study at Waldorf High School in Maryland?

Answer: Yes


Has the video Castle on the Hill had more than 100 million views on YouTube?

Answer: Yes


Does failure of the left ventricle of the heart in pulmonary hypertension cause the lungs to be overloaded with fluid?

Answer: Yes


Answer: Not Sure Enough


Have Manchester United won over 64 competitive trophies?

Answer: Yes


Answer: Not Sure Enough


Has FanMail sold over 5.5 million copies in the US?

Answer: Yes


Did Christian Benteke play in Anfield Stadium in 2017?

Answer: Yes


Did Cristiano Ronaldo score more than 38 goals in a season?

Answer: Yes


Did Tajh Boyd have less than 130 rushing yards?

Answer: Yes


Is Bas Dost one of the best scorers in Portugal's league?

Answer: Yes


Did both BBC and AMC request a new season of The Night Series?

Answer: Yes


Is PCOO the acronym for the Presidential Communications Group of the Philippines?

Answer: Yes


Did Bas Dost start playing professionally at FC Jostoos?

Answer: Yes


Does Dominic Solanke-Mitchell play for Chelsea?

Answer: Yes


Does Dominic Solanke play for Liverpool?

Answer: Yes


Did Ben McLemore play for the Sacramento Kings?

Answer: Yes


Was The EP, The North Stands for Nothing, released by While She Sleeps in 2010?

Answer: Yes


Is the relationship between Gwen and Peter in The Amazing Spider-Man film based on the Ultimate versions of Peter and Mary Jane?

Answer: Yes


Is the Chennai International Airport the fourth busiest airport in India?

Answer: Yes


Is Daisy Johnson also known as Tremors and Skye?

Answer: Yes


Was Ben McLemore born in Wellstone, Missouri?

Answer: Yes


Does Damir Džumhur have a record of more than 45 wins?

Answer: Yes


Does Damir Džumhur have a total record of more than 61 losses?

Answer: Yes


Did the ranking by Next Generation end before August 2006?

Answer: Yes


Was the game Enter the Matrix published by Atari, Inc?

Answer: Yes


Are GluA1, GluA2, GluA3, and GluA4 subunits?

Answer: Yes


Has "Castle on the Hill" sold more than 740,000 downloads in the US?

Answer: Yes


Does summer last less than seven months in Limassol?

Answer: Yes


Did Greg McPherson stop touring with the band during late 1990?

Answer: Not Sure Enough


Has Dominique Rodgers sired a dozen children with 8 different women?

Answer: Yes


Answer: Yes


Did Argento begin planning for his directorial debut after 1968?

Answer: Yes


Does Boulder have a humid subtropical climate?

Answer: Yes


Answer: Yes


Did the man hired by Salim-Javed drive a jeep?

Answer: Yes


Is the Los Angeles Times part of the Tribune Company?

Answer: Not Sure Enough


Answer: Yes


Answer: Yes


Answer: Yes


Does the Howard family live in Arundel Castle?

Answer: Yes


Did Donovan miss the first two World Cup qualifiers of 2013?

Answer: Yes


Was Sanchez transferred to Manchester United according to the announcement made on January 22, 2018?

Answer: Yes


Does Sánchez's contract with Arsenal end in the summer?

Answer: Yes


Was Ashcroft confirmed as Liam Gallagher's support at two concerts in June 2018 at Malahide Castle and Gardens in Dublin and Belsonic at Ormeau Park in Belfast?

Answer: Yes


Is Gus Robertson the lead guitarist of Razorlight?

Answer: Not Sure Enough


Is OPPO Morocco a regional division of OPPO?

Answer: Yes


Does the sampler shift the sample down a semitone when it has a G2 note and shift it a semitone higher for A2?

Answer: Yes


Was the Cape Wine Academy founded after 1988?

Answer: Yes


Answer: Yes


Does America need renewable energy to prevent pollution, considering that more than 70% of Americans have heat and air-conditioning?

Answer: Yes


Are Paul Blart's daughter and mother known as Maya and Margaret?

Answer: Yes


Does American Football player Case Keenum play for the Minnesota Vikings?

Answer: Yes


Did Keenum sign a 5-year contract with the Vikings in 2018?

Answer: Yes


Were Cam'ron and Jim Jones childhood friends?

Answer: Yes


Did Sonu Nigam begin singing when he was four and a half years old?

Answer: Yes


Answer: Yes


Did the Broncos want to improve from their 5-11 record in the 2017 season?

Answer: Yes


Was Tomb Raider: Definitive Edition released in Australia on 30 January, 2014?

Answer: Yes


Can three players play in Call of Duty Black Ops 2's Turned mode?

Answer: Yes


Answer: Yes


Was the price of the OPPO N3 $449 in 2016?

Answer: Yes


Does the film The House That Jack Built have an approval rating of less than 51% and an average rating of less than 6/10 on Rotten Tomatoes, based on more than 29 critics?

Answer: Yes


Did Dario Argento finish the final film of his Three Mothers trilogy in 2007?

Answer: Yes


Was Deadpool 2's soundtrack released on the same day as the film's release?

Answer: Yes


Did Bast Dost play with the Netherlands national team and in Portugal's Sporting CP?

Answer: Yes


Is Mesa 3D one of the open-source projects supported by Intel?

Answer: Yes


Is the approval rating for "Meet the Blacks" on Rotten Tomatoes over 50%?

Answer: Yes


Was Roberto Baggio awarded the 1994 Onze de Bronze?

Answer: Yes


Is Roberto Baggio Juventus' ninth player with the most goals and the tenth player with the most goals for the team in Serie A?

Answer: Yes


Did Jamiroquai sell over 2 million copies of his album in the US?

Answer: Not Sure Enough


Did The Death of Superman receive ambiguous or flattering reviews?

Answer: Yes


Was Roberto Baggio a very successful goalscorer?

Answer: Not Sure Enough


Does The Death of Superman have a rating of more than 85% on Rotten Tomatoes?

Answer: Yes


Did Solanke debut with Sligo Rovers in 2014?

Answer: Yes


Has Sonu Nigam sung more than 500 Kannada songs?

Answer: Yes


Is 88rising an American mass media company?

Answer: Yes


Did the main character of "The House that Jack Built" mutilate a duckling in his childhood?

Answer: Yes


Was De'Anthony Melton a rookie guard in 2018?

Answer: Yes


Did Bharat Ane Nenu earn more than 430 crores in its full theatrical run?

Answer: Yes


Answer: Yes


Did over 10 scientists participate in the study published in A Journal of Clinical Investigation?

Answer: Yes


Did Benny Blanco listen to All-4-One's "I Swear" at an early age?

Answer: Yes


Did the Imperial Japanese Navy launch its attack on Pearl Harbor on December 7, 1941?

Answer: Yes


Is Bjorn Agren a guitarist in Razorlight?

Answer: Yes


Did Fort Minor appear on the TBS late-night talk show on June 22nd, 2015?

Answer: Yes


Is business one of the three classes of service offered by Air Canada?

Answer: Not Sure Enough


Do reviewers on Rotten Tomatoes unanimously agree that Peter Capaldi spices up Dr Who with boldness and humor?

Answer: Yes


Is The Brave Little Toaster a musical animated comedy?

Answer: Yes


Does the development of Day Z focus on introducing a better inventory system?

Answer: Yes


Does Jahana Hayes support single-payer health care?

Answer: Yes


Did Benny Blanco release his second and third singles later in 2018?

Answer: Yes


Was Trash Boat part of the support acts for While She Sleeps tour?

Answer: Yes


Does Patrick Fabian play the role of Hank Henshaw in the movie The Death of Superman?

Answer: Yes


Is Benny Blanco's debut album going to be released on December 7th, 2018?

Answer: Yes


Does The Death of Superman have a rating of over 91% based on more than 11 reviews?

Answer: Yes


Does Oppo Electronics Corporation produce Blu-ray players?

Answer: Yes


Does The House That Jack Built have an approval rating of over 59.5% on Rotten Tomatoes?

Answer: Yes


Has The House That Jack Built made more than $1.5 million in total global sales?

Answer: Yes


Does The Good Place have a podcast version?

Answer: Yes


Does The House That Jack Built have more than 98 reviews on Rotten Tomatoes?

Answer: Yes


Answer: Yes


Has The House That Jack Built made more than $1,810,000 globally?

Answer: Yes


Did Dell contribute more than 15% of Intel's total revenue in 2017?

Answer: Yes


Did The House That Jack Built receive more than 10 nominations at the Robert Awards?

Answer: Yes


Were Russo and the Schultzes killed in season 2 of The Punisher?

Answer: Yes


Is there a scene in The Death of Superman where his logo is dripping blood with a black screen behind?

Answer: Yes


Did Jack tie fewer than six people to a post in the film The House That Jack Built?

Answer: Yes


Did Nicki Minaj release her fourth studio album in 2018?

Answer: Yes


Is Good Charlotte also considered a ska-punk band?

Answer: Not Sure Enough


Did The House That Jack Built have more than 108 reviews on Rotten Tomatoes?

Answer: Yes


Did The House That Jack Built make over $2.4 M worldwide?

Answer: Yes


Does Brynn Cartelli work for Atlantic Records?

Answer: Yes


Is Dominic Masters in season 4 of the TV show Blindspot?

Answer: Yes


Has the US Men's National Ice Hockey Team won more than 18 World Championship medals?

Answer: Yes


Is Cartoon Network's block of preschooler shows called Tickle-U and does it include Gordon The Garden Gnome and Firehouse Tales, which launched on August 22?

Answer: Yes


Did The House That Jack Built gross over $2.25 million in other territories apart from North America for a worldwide total of over $2.5 million?

Answer: Yes


Does the Adult Swim show run from 8:00 pm to 6:00 am?

Answer: Yes


Did The House That Jack Built gross over $2.29 million in territories outside the U.S and a worldwide total over $2.55 million?

Answer: Yes


Did Gloria Bell gross more than $1 million outside of the United States and Canada and a worldwide total of more than $6.3 million?

Answer: Yes


Is Honeywell's headquarters located in Morris Plains, New Jersey?

Answer: Yes


Has Nicki Minaj released more than one hundred and four singles?

Answer: Yes


Is the rating of The House That Jack Built less than 59% based on more than 110 reviews and an average rating of less than 6/10 on Rotten Tomatoes?

Answer: Yes


Does Biggie Cheese portray Mr. Boombastic in the movie Barnyard?

Answer: Yes


Is The SpongeBob Movie: Sponge Out of Water dedicated to Ernest Borgnine?

Answer: Yes


Has Gloria Bell grossed more than $3 million in territories other than the United States and Canada, and a total of more than $8.5 million worldwide?

Answer: Yes


Were New Kids on the Block on tour with their Mixtape Tour after 2018?

Answer: Yes


Answer: Not Sure Enough


Did Andrea Barzagli retire after his 73rd appearance?

Answer: Yes


Is the owner of Cartoon Network Warner Bros. Global Kids & Young Adults, a branch of AT&T's WarnerMedia?

Answer: Not Sure Enough


Does Gloria Bell have more than 37 reviews on Metacritic?

Answer: Yes


Did President Abdurrahman Wahid's impeachment take place on the night of 23 July 2001?

Answer: Yes


Is Good Charlotte influenced by bands like Sublime and the British band Architects?

Answer: Not Sure Enough


Is Oppo located in Dongguan, Guangdong, China?

Answer: Yes


Did Tibbitt write on Twitter before 2012 that he and Steve Hillenburg worked every day on The SpongeBob Movie: Sponge Out of Water?

Answer: Yes


Do more than 70% of households with television receive FXX?

Answer: Yes


Is Metallica's fifth studio album commonly known as The Black Album?

Answer: Yes


Did American Airlines start offering flights on its Boeing 777-300 in 2019?

Answer: Yes


Was Liverpool placed second in their domestic league?

Answer: Yes


Does he discover a new set of abilities, including agility and super-strength?

Answer: Yes


Did Gunting Lagadan of Bundu Tuhan and Lemaing of Kampung Kiau climb Mount Kinabalu with Hugh Low?

Answer: Yes


Is Kim Petras' Clarity considered bubblegum pop?

Answer: Not Sure Enough


Did Akshay Kumar play a lead role in Jaani Dushman: Ek Anokhi Kahani?

Answer: Yes


Is Edgware located south-east of Watford?

Answer: Yes


Was Street Kings reviewed by more than 151 critics on Rotten Tomatoes?

Answer: Yes


Was Just Mercy released before January 1, 2020?

Answer: Yes


Did Just Mercy score over 86.5% with a score of more than 7/10 when averaged over 44 reviewers?

Answer: Yes


Did the financial gains from the album help Dr. Luke with his legal defense against Kesha?

Answer: Yes


Does the Indian Government own more than 65% shares in BPCL, with Foreign Portfolio Investors and the BPCL trust having less than 15% and 7% respectively?

Answer: Yes


Was the failed attempt to recall the Assembly to block the decriminalization of abortion on October 21, 2019?

Answer: Yes


Was Ava Bailey Quinn born on August 16, 2007 at 13.45 GMT?

Answer: Not Sure Enough


Did John Carew star as Jungle Warrior Fey?

Answer: Yes


Does Maleficent return to the Moors after Aurora's wedding?

Answer: Yes


Was James Vardy released by the Porcupine Warriors at 16?

Answer: Yes


Did Jamie Vardy speak with Kwesi Appiah of the Ghana national team?

Answer: Yes


Did Vardy play against the Netherlands at Wembley?

Answer: Yes


Is Landon Donovan a retired soccer player who manages the USL Championship side, San Diego Loyal SC?

Answer: Yes


Does Maleficent need to earn an average of $437.5 to break even with costs?

Answer: Yes


Was the 14th-century post-wedding handbag gifting after the couple got intimate?

Answer: Yes


Was Richard Ashcroft the Verve's lyricist?

Answer: Yes


Is Blindspot produced by Berlanti Productions, Quinn's House, and Warner Bros?

Answer: Not Sure Enough


Did she awaken in an underground cavern?

Answer: Not Sure Enough


Did the movie score more than 77% based on more than 13 reviews?

Answer: Yes


Did Razorlight play in T in the Park in Balado, Scotland?

Answer: Not Sure Enough


Answer: Yes


Is the music for Marakkar: Arabikadalinte Simham composed and produced by Rahul Raj?

Answer: Yes


Will Marakkar: Arabikadalinte Simham be released on March 19, 2020?

Answer: Yes


Does Minaj accumulate 106 chart entries on the Billboard Hot 100?

Answer: Yes


Is Bryan Stevenson a young attorney in Just Mercy?

Answer: Not Sure Enough


Is Sonu Nigam considered one of the best singers in the history of the Hindi film industry?

Answer: Yes


Does the main character in Gary Windass find out that Shona has recovered from a gunshot wound?

Answer: Yes


Does Just Mercy have more than 75 reviews?

Answer: Yes


Was Just Mercy rated 78% and did it receive a score of 6.51/10?

Answer: Yes


Did Moon Bloodgood marry a former Chicago White Sox player?

Answer: Yes


Is Bryan Stevenson's memoir titled Just Mercy?

Answer: Not Sure Enough


Has Maleficent: Mistress of Evil made more than $491 million globally?

Answer: Yes


Has Nicki Minaj released fewer than 10 studio albums?

Answer: Yes


Did reviewers on CinemaScore give Paul Blart: Mall Cop a mostly positive rating?

Answer: Yes


Answer: Yes


Does Paolo Nutini have a younger cousin named Ciaran?

Answer: Yes


Was Paolo Nutini named after his father's friend "Paolo", who was the owner of a famous bar in Barga called "Paolo Gas"?

Answer: Yes


Answer: Yes


Was Nketiah's loan stint cut short when he was recalled by Arsenal?

Answer: Not Sure Enough


Did Spain beat Turkey by 3-0 in the UEFA Euro 2016?

Answer: Yes


Was Nolito named in the squad for the final tournament?

Answer: Yes


Answer: Yes


Were the field goal records originally set in 1970 followed by 1998, 2011, 2012, and 2018?

Answer: Yes


Did the NCAA ban the kicking tee for field goals and extra points?

Answer: Yes


Was Rob Bourdon the founding member of Linkin Park?

Answer: Yes


Did Babylon A.D score below 51% with more than 50 negative reviews and less than 51 positive reviews, with the general consensus being negative?

Answer: Yes


Answer: Yes


Is Dr. Darquandier's first name Arthur in Babylon A.D?

Answer: Yes


Was Babylon A.D. panned by critics despite being a minor commercial success?

Answer: Yes


Did Babylon A.D earn more than $56 million worldwide after December 2008?

Answer: Yes


Did Wan-Bissaka sign a contract for more than 10 years with Manchester United?

Answer: Yes


Was Wan-Bissaka named the club's Player of the Month for March?

Answer: Yes


Did Journey 2: The Mysterious Island score 43% based on more than 127 reviews?

Answer: Yes


Were there less than 30 million people speaking Amharic in 2007, including 4 million L2 speakers?

Answer: Yes


Was Karen Darabedyan's defeat against Daniel Straus a unanimous decision?

Answer: Yes


Is the river Sangarius known as the Sakarya river?

Answer: Yes


Is Boli Bolingoli-Mbombo a footballer and Jordan Lukaku's cousin?

Answer: Yes


Answer: Yes


Did Violet Brown's mother die at age 96?

Answer: Not Sure Enough


Did the Madden NFL game simulations predict more than nine out of 14 Super Bowl winners?

Answer: Yes


Is Mark Viduka an Australian association football centre forward of Croatian descent?

Answer: Yes


Does X-Men: The Last Stand have an approval rating of less than 60% on Rotten Tomatoes?

Answer: Yes


Was the opera Ascanio based on Alexandre Dumas' work?

Answer: Yes


Was Cosmos: Possible Worlds scheduled for release on Fox in 2019?

Answer: Not Sure Enough


Is Mendes, whose first name is Sam, the director of Skyfall?

Answer: Yes


Answer: Not Sure Enough


Did Shea Weber win an Olympic gold medal in 2014?

Answer: Yes


Is Tom Hiddleston expected to participate in the last movies of Avengers?

Answer: Yes


Do the Chennai Super Kings and the Mumbai Indians hold a record for being the teams that played against each other most times?

Answer: Yes


Did the Mumbai Indians win more than 12 matches against the Chennai Super Kings?

Answer: Yes


Did Jordy Nelson's team lose 33-28 against the Chicago Bears?

Answer: Yes


Did Jordy Nelson's team win 43-37 over the Atlanta Falcons?

Answer: Yes


Did Matthew Goode appear in the film Chasing Liberty?

Answer: Yes


Is Justin Donovan Houston a defensive end?

Answer: Yes


Does Justin Houston play for the Cincinnati Bengals?

Answer: Yes


Was Justin Donovan Houston born after 15 January 1989?

Answer: Yes


Was Justin Houston drafted by the Chiefs in the third round of the 2011 NFL Draft?

Answer: Yes


Does Uttarakhand host the following fairs: Bikhauti Fair, Haatkalika Fair, Jageshwar Fair and Purnagiri Fair?

Answer: Yes


Was Double Dhamaal a moderate commercial success?

Answer: Yes


Can FreeDOS be used with a driver called LFNDOS?

Answer: Yes


Does she tell Chad that they will control the world together?

Answer: Yes


Does Ayesha hire Yondu Udonta and his crew on Contraxia in Guardians of the Galaxy Vol. 2?

Answer: Yes


Was the movie Vettai released in 650 screens worldwide?

Answer: Yes


Does the movie Fun and Fancy Free use live-action segments to join its two stories together?

Answer: Yes


Did Leon Thomas choose the movie Collateral Beauty as the worst movie before 2017?

Answer: Yes


Does El Peluca star as the character Howard Inlet in the movie Collateral Beauty?

Answer: Yes


Does the character Howard Inlet become borderline suicidal in the movie Collateral Beauty?

Answer: Not Sure Enough


Did the movie Collateral Beauty have negative reviews?

Answer: Yes


Did the movie Collateral Beauty receive negative reviews?

Answer: Not Sure Enough


Does the movie Collateral Beauty star Jacob Latimore?

Answer: Yes


Does the movie Collateral Beauty have an approval rating of more than 13% and has it been reviewed by more than 98 critics, according to Rotten Tomatoes?

Answer: Yes


Has the movie Collateral Beauty been reviewed by more than 37 critics on Metacritic?

Answer: Yes


Does the movie Collateral Beauty reveal moments of meaning and beauty through the deepest loss?

Answer: Yes


Has the movie Collateral Beauty been reviewed by more than 94 critics and does it have an average rating of more than 35% on Rotten Tomatoes?

Answer: Yes


Does the movie Collateral Beauty have an approval rating of less than 13% based on more than 71 reviews on Rotten Tomatoes?

Answer: Yes


Does the movie Collateral Beauty have an approval rating of less than 14% based on more than 67 reviews on Rotten Tomatoes?

Answer: Yes


Has the movie Collateral Beauty been reviewed by more than 30 critics on Metacritic?

Answer: Yes


Does the movie Collateral Beauty have an average score of less than 25% based on more than 28 critics on Metacritic?

Answer: Yes


Does the movie Collateral Beauty have an average score of less than 26% based on more than 24 critics on Metacritic?

Answer: Yes


Does the movie Collateral Beauty have an approval rating of more than 23%, has it been reviewed by more than 24 critics and does it have an average rating of more than 4.3/10, according to Rotten Tomatoes?

Answer: Yes


Does the movie Collateral Beauty have an average score of more than 24% and has it been reviewed by more than 11 critics according to Metacritic?

Answer: Yes


Does the movie Collateral Beauty have an approval rating of less than 12% according to Rotten Tomatoes and has it been reviewed by more than 8 critics?

Answer: Yes


Did Garfield: A Tail of Two Kitties receive positive reviews?

Answer: Yes


Is Garfield 2: The Prince and the Paw-per the name for Garfield: A Tail of Two Kitties in the UK?

Answer: Not Sure Enough


Does James own every episode of the show on VHS Tape in the film Brigsby Bear?

Answer: Yes


Did Brigsby Bear receive more than 109 reviews on Rotten Tomatoes after premiering in New York on July 26, 2017?

Answer: Yes


Does Brigsby Bear have more than 93 reviews on Rotten Tomatoes?

Answer: Yes


Does Brigsby Bear have more than 62 reviews on Rotten Tomatoes to determine its rating?

Answer: Yes


Is James asking Vogel where he can watch the newest episode of Brigsby Bear in the film Brigsby Bear?

Answer: Not Sure Enough


Does Brigsby Bear have a rating of less than 86% and an average rating of less than 6.9/10, as defined by more than 38 reviews?

Answer: Yes


Is Brigsby Bear's rating on Rotten Tomatoes over 85% with more than 35 reviews?

Answer: Yes


Is Dalida one of the first singers to sing disco songs in France in the film Dalida?

Answer: Yes


Has Wuhan attracted foreign investment from over 80 countries as of 2016?

Answer: Yes


Did the epidemic emerge from Wuhan's Huanan Seafood Wholesale Market, according to speculations?

Answer: Yes


Did Vishnuvardhan select Rajkannan as the dialogue writer for the film Billa?

Answer: Yes


Did the film Billa make under 50 million in Chennai?

Answer: Yes


Is a family haunted by events from supernatural forces in The Haunting in Connecticut?

Answer: Yes


Was Nancy Margaret Clancy voiced by Isabella Cramp and Stephanie Sheh in the Fancy Nancy series?

Answer: Yes


Did Roger Ebert award the film Dick Tracy four stars?

Answer: Yes


Is the character Podrick in Breaker of Chains portrayed by Daniel Portman?

Answer: Yes


Did Blockbuster close its stores before 2015?

Answer: Not Sure Enough


Did the club initially charge a subscription fee of $25 and $5 per rental before becoming Family Video?

Answer: Yes


Were there under 450 reactors with a net capacity of under 390,000 MWe operational in the world as of December 2017?

Answer: Yes


Will Belarus start its first nuclear power plant?

Answer: Yes


Is Bauer Media Group, a German multimedia conglomerate, formerly known as Bauer Verlagsgruppe?

Answer: Yes


Is the current name of the Bauer publishing conglomerate the Bauer Media Group?

Answer: Yes


Answer: Yes


Is the character Seth played by Nicolas Cage in the movie City of Angels?

Answer: Yes


Did numerous fans criticize the episode Beyond the Wall?

Answer: Not Sure Enough


Answer: Yes


Did Tenerife and Hospitalet play against each other on 2 June 2013?

Answer: Yes


Was the song "Dumb Blonde" released in the United States as the second single and third overall from the album in 2019?

Answer: Not Sure Enough


Were McKee, Chris Baseford, and Scott Robinson involved in the production of the song Dumb Blonde?

Answer: Yes


Answer: Yes


Was Chris Webber traded in exchange for Penny Hardaway?

Answer: Yes


Does Hawaiian Airlines operate flights to American Samoa?

Answer: Yes


Did Hawaiian Airlines order more than sixteen A321neos?

Answer: Yes


Did Focus receive fewer than 181 reviews?

Answer: Yes


Did principal photography for Focus (film) start after September 13, 2013 in New Orleans and transfer to Buenos Aires after November 18, 2013?

Answer: Yes


Did Focus (film) receive a rating above 57% and more than 120 reviews?

Answer: Yes


Did Focus (film) receive a rating above 56% and more than 105 reviews?

Answer: Yes


Did Focus (film) receive a score below 56% from more than 25 critics?

Answer: Yes


Did Focus (film) receive an approval rating of below 60%, with more than 40 reviews, and an average rating below 6.2/10?

Answer: Yes


Did the film Focus have an approval rating below 65% with more than 35 reviews?

Answer: Yes


Did the Microsoft Windows version receive more than 22 reviews, while the Xbox One version scored below 77.5% based on more than 10 reviews?

Answer: Yes


Is Vol. 3: The Subliminal Verses by Slipknot?

Answer: Yes


Is Slipknot's fourth studio album called The Subliminal Verses?

Answer: Yes


Is Lil Pump currently among the artists signed to Warner Bros. Records?

Answer: Yes


Did The Odd Life of Timothy Green receive mixed and unfavorable reactions?

Answer: Yes


Did The Odd Life of Timothy Green make over $38 million after September 3rd?

Answer: Yes


Did The Odd Life of Timothy Green make over $25 million after August 25th?

Answer: Yes


Is Mary in the final scene of the But I'm a Cheerleader film?

Answer: Yes


Does Kimberly find pictures of nude women in Megan's locker in But I'm a Cheerleader?

Answer: Yes


Answer: Yes


Did Ghost Rider receive a rating higher than 30% on Metacritic?

Answer: Yes


Does Napoleon hate his Uncle Rico in the TV series Napoleon Dynamite?

Answer: Yes


Does Brampton East include the majority of Jagmeet Singh's former provincial riding?

Answer: Yes


Answer: Yes


Is a sample of the song Freak on a Leash featured in the film Dope, which contrasts the movie's hip-hop theme?

Answer: Yes


Does the film Dope have over 117 reviews on Rotten Tomatoes?

Answer: Yes


Does dope have a rating below 91% and an average rating below 7.6/10?

Answer: Yes


Answer: Yes


Was How to Train Your Dragon: The Hidden World one of the highest-earning animated films of the year it was released?

Answer: Yes


Does How to Train Your Dragon: The Hidden World have over 243 reviews and an average rating below 7.26/10?

Answer: Yes


Did How to Train Your Dragon: The Hidden World gross over $56 million on its debut?

Answer: Yes


Does How to Train Your Dragon: The Hidden World have over 238 reviews and an average rating of 7.22/10 or higher on Rotten Tomatoes?

Answer: Yes


Does Hiccup climb on Light Fury in the film How to Train Your Dragon: The Hidden World?

Answer: Yes


Does Hiccup fall in love in the film How to Train Your Dragon: The Hidden World?

Answer: Yes


Is How to Train Your Dragon: The Hidden World the third movie in the How to Train Your Dragon film trilogy?

Answer: Yes


Does How to Train Your Dragon: The Hidden World have over 230 reviews and an approval rating below 91% on Rotten Tomatoes?

Answer: Yes


Is the Wii Remote Plus a new version of the controller?

Answer: Not Sure Enough


Was Wii Sports the best-selling video game of all time?

Answer: Yes


Did Nintendo file the trademark "Wii" in 2006?

Answer: Not Sure Enough


Is some content in What Women Want considered unsuitable for children?

Answer: Yes


Did Del Toro make an appearance at The Game Awards 2017?

Answer: Yes


Does the city of Hamilton, Ontario have more than 100 waterfalls?

Answer: Not Sure Enough


Does the 2017 edition of Matthew Bender state that overvotes and undervotes can occur in corporate proxy situations?

Answer: Yes


Are the Kansas City Royals an American baseball team?

Answer: Yes


Does Assassin's Creed Rogue's story begin some years after the events of Assassin's Creed: Black Flag?

Answer: Yes


Does Shay have to prevent an innocent person from being killed in Assassin's Creed Rogue?

Answer: Yes


Is Assassin's Creed Rogue a work of fiction?

Answer: Not Sure Enough


Was it announced that the 2019 Algerian presidential election would happen after July 3 before April 11?

Answer: Not Sure Enough


Was Fred Astaire successful in getting Irwin Allen's No Hold On to the Building's on Fire included in the movie?

Answer: Yes


Does Maná play progressive rock songs among other genres?

Answer: Yes


Had Maná sold more than 35 million albums by 2013?

Answer: Yes


Did Maná support Puerto Rico's independence from the United States?

Answer: Yes


Did Maná earn more than six Latin Grammy Awards and more than four Premios Juventud awards?

Answer: Yes


Answer: Yes


Has it been less than four years since Sawyer saved "Winter" in Dolphin Tale 2?

Answer: Yes


Did Dolphin Tale 2 receive a rating higher than 73% on Rotten Tomatoes after 43 reviews?

Answer: Yes


Are Matt and Lisa reunited in Wicker Park after seeing each other in the crowd?

Answer: Yes


Is Wicker Park based on Shakespeare's A Midsummer's Night Dream?

Answer: Yes


Did the film receive an approval rating of 82% on Rotten Tomatoes after 45 reviews?

Answer: Yes


Did Cargo receive an approval rating higher than 82% on Rotten Tomatoes after 43 reviews?

Answer: Yes


Is Sarah Michelle Gellar best known for portraying the title character in the series Buffy the Vampire Slayer?

Answer: Yes


Was Fred Claus released in the United Kingdom on November 30, 2007?

Answer: Yes


Answer: Yes


Is The Hold Steady known for its lyrically dense storytelling?

Answer: Yes


Is "I Can't Help It" a hit song by the band Bananarama?

Answer: Yes


Did the trio Bananarama perform the song "Venus" at the London Palladium on May 10th?

Answer: Not Sure Enough


Was the song "Really Saying Something" originally sung by the Velvelettes or the band Bananarama?

Answer: Yes


Did the 2018 NHL Entry Draft feature the first Jamaican born player drafted in Jermaine Loewen?

Answer: Yes


Will the Ottawa Senators receive the New Jersey Devil's second-round pick in the 2018 NHL Entry Draft?

Answer: Yes


Does Hakeem Nicks play for the Cleveland Browns?

Answer: Yes


Is the character of Victoria Everglot played by Emma Watson in the movie Corpse Bride?

Answer: Yes


Is the movie Corpse Bride set in an unnamed Victorian-era European village, somewhere in England or France?

Answer: Yes


Did Moby's Innocent collection have a post apocalyptic theme?

Answer: Yes


Were the sales of Confessions of a Dangerous Mind lower than Logic's other projects?

Answer: Yes


"Is Confessions of a Dangerous Mind Logic's sixth studio album?"

Answer: Yes


Is Episode IV of Star Wars titled "A New Hope"?

Answer: Yes


Is Dee Bradley Baker called Clone Troopers in the game Star Wars Jedi?

Answer: Yes


Did Knowshon Moreno sign a five-year contract worth more than $16.7 million with a club option of less than $3 million?

Answer: Yes


Was the complete acquisition of Microsemi announced on May 29, 2018?

Answer: Not Sure Enough


Did Rayner miss a 46-yard goal in the game against the Lions, keeping the game tied?

Answer: Yes


Is the Steelers defense ranked at number 1?

Answer: Yes


Did BenJarvus Green-Ellis score on a two-yard touchdown run for the Patriots?

Answer: Not Sure Enough


Did the Patriots take the kickoff for 52 yards in 9 plays?

Answer: Yes


Did McCourty intercept Sanchez at the Patriots 6 with no score, on the second play of the Jets' drive?

Answer: Yes


Did the Jets march 73 yards in 12 plays, taking 7 minutes off the clock, with Braylon Edwards scoring on a 10-yard touchdown pass from Mark Sanchez?

Answer: Yes


Answer: Yes


Did Brady's 25-yard touchdown pass to Gronkowski give the Patriots an insurmountable 36-18 lead with 4:23 remaining?

Answer: Yes


Did the New England Patriots' first three possessions of the game end in punts?

Answer: Yes


Did the Patriots take their lead to 24-3 in the second quarter?

Answer: Yes


Did Detroit come back with a 1-yard touchdown plunge over New England in the NFL?

Answer: Not Sure Enough


Is it true that game times from Weeks 16-17 are subject to change due to flexible scheduling?

Answer: Yes


Does the film Dante's Peak show the remains of a volcano?

Answer: Yes


Is Ruth Rachel's former mother-in-law in the film Dante's Peak?

Answer: Yes


Did Beşiktaş have Les Ferdinand on loan in 1988?

Answer: Yes


Is Les Ferdinand's deal with Queens Park Rangers considered expensive?

Answer: Not Sure Enough


Was Morrison Hotel Jim Morrison's favorite Doors album?

Answer: Yes


Did Kshmr release "Opa" on July 22, 2018 with Dimitri Vegas and Like Mike?

Answer: Yes


Did Kshmr collaborate with Will Sparks for his new song, Voices?

Answer: Yes


Is Niles Hollowell-Dhar Indian-American?

Answer: Not Sure Enough


Do honorary members of Rotary International include Neil A. Armstrong, Douglas MacArthur, and Walt Disney?

Answer: Not Sure Enough


Did other English clubs have a record of 0% success before Liverpool's victory in 2019?

Answer: Yes


Answer: Yes


Answer: Yes


Can Adrain Mutu play as a supporting forward, a striker, and a winger?

Answer: Not Sure Enough


Did Adrian Mutu join Juventus again because he failed a drug test?

Answer: Yes


Is Adrian Mutu usually compared to Gheorghe Hagi?

Answer: Yes


Is S. Robson Walton poorer than the 15th wealthiest person in the world?

Answer: Yes


Has the liberal media drawn parallels between Idiocracy and Trump's presidency?

Answer: Yes


Did Fox rely on word-of-mouth marketing for Idiocracy?

Answer: Yes


Is Idiocracy a film about a top-secret military hibernation experiment done on humans?

Answer: Yes


Did Rodri make his first appearance in La Liga in 2016?

Answer: Yes


Did Lisa Stansfield join the charity group Band-Aid II to fight poverty in Ethiopia?

Answer: Yes


Did Lisa Stansfield's Real Love reach number five in the Netherlands, number nine in Germany, and number ten in Belgium?

Answer: Yes


Did Radja Nainggolan post a controversial video on New Year's Eve 2018?

Answer: Yes


Did Radja Nainggolan represent Inter Milan?

Answer: Yes


Did Christian Campbell-Carrigg star in the film Thor?

Answer: Yes


Did Thor receive polarized and average scores?

Answer: Yes


Did Nicky damage his tie with Ginger when she demanded that he kill Sam and instead threw her out?

Answer: Yes


Do B & W boilers supply more than 300,000 megawatts and are they present in 90 countries?

Answer: Yes


Did Lockout receive negative reviews from critics?

Answer: Not Sure Enough


Did Lockout earn a total gross of more than $28 million?

Answer: Yes


Has Lockout grossed more than $13,550,000 in the United States and Canada?

Answer: Yes


Has Lockout grossed more than $12,900,000 in the United States and Canada after April 28, 2012?

Answer: Yes


Was Lockout's rating more than 30% from over 70 reviewers on Rotten Tomatoes?

Answer: Yes


Did the arc lamp make one of the first commercial uses for electricity possible, which was previously reserved for experiment, the telegraph, and entertainment?

Answer: Yes


Does Mark Silk play the voice of Bob the Builder?

Answer: Yes


Was the story of Gears of War 3 written by a science fiction author?

Answer: Yes


Does Griffin dislike COG because his corporation was destroyed in Gears of War 3?

Answer: Yes


Did The Last Exorcism earn more than $60 million with a budget of less than $2 million?

Answer: Yes


Was the film Last Exorcism first shown at the LA Film Festival after February 2010?

Answer: Yes


Does Thrift Shop have over 465 million views on YouTube?

Answer: Yes


Is All Eyez on Me the last studio album by 2Pac?

Answer: Not Sure Enough


Did J-Dilla contribute significantly to the Neo soul movement in the late 1990s?

Answer: Not Sure Enough


Do fans loyal to Briony, Kim-Joy, and Manong complain about the judges' bias?

Answer: Yes


Did Doug Marrone name Kyle Orton the new starting quarterback for the Bills on September 29th?

Answer: Yes


Was Meghan Trainor a guest in Songland where she sought assistance to write her new song Hurt Me?

Answer: Not Sure Enough


Did Barry Manilow release less than 32 studio albums?

Answer: Yes


Did Double Fantasy receive diverse reviews?

Answer: Yes


Does Kal-El / Clark Kent / Superman closely resemble his father Jor-El?

Answer: Not Sure Enough


Is Portugal the winner of the UEFA Euro 2016?

Answer: Yes


Does Zac Brown Band have thirteen songs that reached number 1, including "Chicken Fried", "Toes", "Highway 20 Ride", "Free", "As She's Walking Away", "Colder Weather", "Knee Deep", "Keep Me in Mind", "Goodbye in Her Eyes", "Sweet Annie", "Homegrown", "Loving You Easy", and "Beautiful Drug"?

Answer: Not Sure Enough


Did the song 4 Minutes sell more than 3 million copies in the US?

Answer: Yes


Did the song 4 Minutes receive two Grammy Award nominations at the 2009 ceremony?

Answer: Yes


Did HJK Helsinki play in the group stage of the UEFA Champions League in 1998-99, making them the only team from Finland to have ever done so?

Answer: Yes


Was the song "1999" released after September 2018?

Answer: Yes


Did Sivan have only two other Top 40 singles before "1999" reached number 13 on the UK Singles Chart?

Answer: Yes


Did Kordell Stewart play in the 2001-02 NFL playoffs for Pittsburgh?

Answer: Not Sure Enough


Did Lampard almost score a goal in the final match of the 2008 UEFA Champions League final with Ballack's help?

Answer: Yes


Was Alex Ferguson the manager of Manchester United during the 2008 UEFA Champions League final?

Answer: Yes


Did Cristiano Ronaldo score the first goal of the match in the 2008 UEFA Champions League final?

Answer: Yes


Was the first penalty scored by Anderson in sudden death in the 2008 UEFA Champions League final?

Answer: Yes


Does the scoring leaders data apply to players in games played the day after 25 March 2013?

Answer: Yes


Did Manchester United F.C. compete in Europe for 24 seasons and in the UEFA Champions League for 18 consecutive seasons until the 2013-14 season?

Answer: Yes


Did referee Jonathan Moss dismiss Granit Xhaka?

Answer: Yes


Did the Patriots reach a seventh consecutive AFC Championship Game during the 2017-18 NFL playoffs, extending their own NFL record?

Answer: Yes


Did A Nightmare on Elm Street 4: The Dream Master gross more than $45 million domestically and become the 19th highest-grossing film of 1988, the highest-grossing horror film at the domestic box office in the 1980s, and the highest-grossing Nightmare on Elm Street film until the release of Freddy vs. Jason after 2002?

Answer: Yes


Was the song "A Whole New World" performed by Peabo Bryson and Regina Belle?

Answer: Not Sure Enough


Did Air Supply increase their legacy with the release of an inspiring single?

Answer: Not Sure Enough


Is it true that there are more than 230 firm orders for the Airbus A330neo?

Answer: Yes


Answer: Not Sure Enough


Did Alex Kurtzman co-write the film Star Trek with J. J. Abrahams?

Answer: Yes


Do Algonquian peoples hunt migratory birds and their eggs between April and July?

Answer: Yes