Is the cyclone death toll above 750 and is fighting disease a new challenge?

Answer: Yes


Have you slashed government by 10 percent in Florida resulting in $7 billion?

Answer: No


Does every dropout cost us $72,000 for the life of that person?

Answer: Not Sure Enough


Do Muslim nurses have the option of participating in medical operations without washing their hands?

Answer: No


Did Democrats derail the initially agreed upon amount for Zika funding, even though they initially agreed with Republicans on it?

Answer: Not Sure Enough


Does the U.S. 'gag rule' have a link to a 40% increase in abortions in parts of Africa?

Answer: Yes


Were you sometimes the only 'no' vote on the entire board?

Answer: Yes


Did the trial show that the cystic fibrosis drug helped ease breathing?

Answer: Yes


Does taking fish oil pills during pregnancy result in stronger, healthier kids?

Answer: Yes


Did three border agents in San Diego get very badly hurt by getting hit with rocks and stones?

Answer: Not Sure Enough


Do clusters of illness linked to CBD vapes share a second connection?

Answer: Yes


Does studies in America focus on trouble spots regarding HIV?

Answer: Yes


Did an inmate awaiting mental health treatment die in Aspen jail?

Answer: Yes


Will Sanofi cut U.S. insulin costs for some patients to $99 per month?

Answer: Yes


Does the Stanford team have a blood test to help identify Alzheimer's disease?

Answer: Not Sure Enough


Does the new breast reconstruction technique provide better outcomes and less discomfort for women recovering from breast cancer?

Answer: No


Did Theophilus Van Kannel develop the revolving door because of an aversion to holding open doors for women and other acts of chivalry?

Answer: No


Did U.S. President Donald Trump golf several times and hold a number of rallies after learning about the threat of the coronavirus?

Answer: Yes


Do same-day hip replacements get patients back on their feet?

Answer: No


Does the new transplant research aim to salvage infected donated organs?

Answer: Yes


Do fossils reveal human ancestors' hearing abilities?

Answer: Yes


Did Reince Priebus say that Hillary Clinton took money from the kings of Saudi Arabia, Morocco, Oman, and Yemen?

Answer: Not Sure Enough


Does problems spur FDA caution on insulin pump?

Answer: Yes


Does the NASA twins study explore space, the final genetic frontier?

Answer: Yes


Do Crohn's patients respond to J&J's Stelara in the study?

Answer: Not Sure Enough


Did the Ohio committee reject medical marijuana for anxiety and autism?

Answer: Yes


Did the number of doctors in specialist psychiatry training decrease from 3,187 in 2009 to 2,588 in the first quarter of this year?

Answer: Not Sure Enough


Did H-E-B's "hurricane emergency supplies" include a limit of two on brisket, due to projected storms in Texas?

Answer: Not Sure Enough


Does teen eating habits help to reduce the risk of breast cancer?

Answer: Not Sure Enough


Were more lives lost from violence against women, sex-selective abortion, female infanticide, suicide, egregious maternal mortality, and other sex-linked causes than were lost during all of the wars and civil strife of the 20th century?

Answer: Not Sure Enough


Does boiling orange peels with cayenne pepper and standing over the pot to inhale the steam release mucus from the nasal passage and help eliminate the virus?

Answer: No


Is wrist replacement surgery a last resort for those who wish to save hand's range of motion?

Answer: No


Is the new psoriasis drug more effective than the current treatment?

Answer: No


Did Walter "Blackie" Wetzel, a former leader of the Blackfeet Nation, design the Indian head logo for the Washington D.C. "Redskins" NFL team?

Answer: Yes


Is the UK performing 240,000 Covid-19 tests per day?

Answer: Not Sure Enough


Is determining what is and isn't a Schedule I narcotic a job for Congress?

Answer: Not Sure Enough


Did researchers produce the first widely protective vaccine against chlamydia?

Answer: No


Does the medical examiner's conclusion contradict the official ruling that Health and Human Services drug pricing adviser Daniel Best committed suicide, stating he died of multiple blunt force injuries?

Answer: No


Did a federal judge approve GOP Congressman Trey Gowdy's request to exhume the body of Vince Foster to determine if Bill and Hillary Clinton were involved in his death 23 years ago?

Answer: No


Does the photograph show an eagle catching a drone?

Answer: Yes


Did a Florida dog's heart stop but it was saved by a Christmas miracle?

Answer: Yes


Did another dolphin die at the Arizona aquatic facility?

Answer: Yes


Does the evidence support that the best scenario for kids is having a loving mom and dad?

Answer: No


Did the FDA advisory panel reject J&J drug for acute coronary syndrome?

Answer: Yes


Did the Chinese scientist who performed gene-editing keep much of his work secret?

Answer: Yes


Do 0-dimensional biomaterials lack inductive properties?

Answer: Not Sure Enough


Does 1 in 5 million people in the UK have abnormal PrP positivity?

Answer: No


Is it true that only 1-1% of colorectal cancer patients are diagnosed with regional or distant metastases?

Answer: Not Sure Enough


Do 10% of Sudden infant death syndrome ( SIDS) deaths occur in newborns less than 6 months of age?

Answer: Not Sure Enough


Did 32% of liver transplantation programs require patients to discontinue methadone treatment in 2001?

Answer: Yes


Does 4-PBA treatment reduce endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers?

Answer: Not Sure Enough


Does 4-PBA treatment increase general endoplasmic reticulum stress markers?

Answer: Not Sure Enough


Does a dosage of 40mg/day of folic acid and 2mg/day of vitamin B12 have an effect on chronic kidney disease (CKD) progression?

Answer: Yes


Answer: Not Sure Enough


Do 50% of patients exposed to radiation have activated markers of mesenchymal stem cells?

Answer: Not Sure Enough


Is 53% of perinatal mortality due to low birth weight?

Answer: Not Sure Enough


Are 61% of colorectal cancer patients diagnosed with regional or distant metastases?

Answer: Not Sure Enough


Do 7-day-old adult Caenorhabditis elegans exhibit approximately 5% of the learning capacity seen in 1-day old adults?

Answer: Not Sure Enough


Does 7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults?

Answer: Not Sure Enough


Are 70% of burn patients admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics?

Answer: Not Sure Enough


Do 76-85% of people with severe mental disorder in low and middle income countries receive no treatment?

Answer: Yes


Will 90% of patients with melanoma and an objective response to PD-1 blockade experience a progression in their melanoma?

Answer: Not Sure Enough


Does 90% of sudden infant death syndrome (SIDS) deaths happen in newborns aged less than 6 months?

Answer: Not Sure Enough


Does a 100g dose of chloroquine chemoprophylactic regimen result in retinal toxicity after 1 year of weekly intake?

Answer: Not Sure Enough


Does a weekly intake of a 100g dose of chloroquine chemoprophylactic regimen result in retinal toxicity after 5-6 years?

Answer: Not Sure Enough


Does a Th2 environment impede disease development in patients with systemic lupus erythematosus (SLE)?

Answer: No


Does a breast cancer patient's capacity to metabolize tamoxifen influence treatment outcome?

Answer: Yes


Is eligibility for GAVI indicative of accelerated adoption of the Hub vaccine in a country?

Answer: No


Does a deficiency of folate increase blood levels of homocysteine?

Answer: Yes


Does a deficiency of vitamin B12 decrease blood levels of homocysteine?

Answer: Not Sure Enough


Does a deficiency of vitamin B6 decrease blood levels of homocysteine?

Answer: Not Sure Enough


Does a diminished ovarian reserve indicate infertility in a non-infertile population as the sole factor?

Answer: Yes


Is a diminished ovarian reserve a strong indicator of infertility, even in a non-infertile population?

Answer: No


Does a high microerythrocyte count protect against severe anemia in homozygous alpha (+)- thalassemia trait subjects?

Answer: Yes


Is a low percentage of hematopoietic progenitor cells susceptible to HIV-1 infection ex vivo?

Answer: Not Sure Enough


Does a mutation in HNF4A increase the risk of developing diabetes by the age of 14 years?

Answer: Yes


Does a mutation in HNF4A lead to an increased risk of diabetes by the age of 14 years?

Answer: Not Sure Enough


Is a single nucleotide variant in the gene DGKK strongly associated with an increased risk of hypospadias?

Answer: Yes


Has a strong bias been observed in the phage genome locations where the spacers were derived in many CRISPR subtypes that confer immunity to phage?

Answer: Yes


Is ALDH1 expression associated with poorer prognosis for primary breast cancer tumors?

Answer: Yes


Does AMP-activated protein kinase (AMPK) activation reduce inflammation-related fibrosis in the lungs?

Answer: Yes


Does the expression of APOE4 in iPSC-derived neurons lead to a decrease in tau phosphorylation?

Answer: No


Does ART have any effect on the infectiveness of HIV-positive people?

Answer: No


Does ART substantially reduce infectiveness of HIV-positive people?

Answer: Yes


Is ATF4 a general endoplasmic reticulum stress marker?

Answer: Not Sure Enough


Are ATM and Rad3 related protein critical for sensing DNA damage?

Answer: Not Sure Enough


Do ATM and Rad3 related protein have a role in sensing DNA damage?

Answer: Not Sure Enough


Does giving AZT with ribavirin increase anemia?

Answer: Not Sure Enough


Does activated Cdk5 phosphorylate the ATM protein in response to DNA damage?

Answer: Yes


Does activated Cdk5 regulate DNA damage-induced neuronal death?

Answer: Yes


Does activation of PPM1D enhance p53 function?

Answer: No


Does activation of the Rac1 homolog CED-10 result in killing viable cells in SRGP-1 mutant Caenorhabditis elegans?

Answer: Yes


Are activator-inhibitor pairs provided ventrally by Xrl-sizzled?

Answer: Not Sure Enough


Does active H. pylori urease have a polymeric structure consisting of five distinct subunits?

Answer: Not Sure Enough


Does Active Ly49Q induce neutrophil polarization?

Answer: Yes


Does active Ly49Q prevent neutrophil polarization?

Answer: No


Does active caspase-11 participate in regulating phagosome-lysosome fusion?

Answer: Yes


Does the active caspase-11 protein promote pyroptosis?

Answer: Yes


Does acute ablation of KRAS cause severe growth impairment?

Answer: Not Sure Enough


Does acute ablation of Snail in the embryonic cortex affect the proliferation and number of embryonic cortical precursors?

Answer: Not Sure Enough


Does the addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generate, expand and maintain cardiovascular progenitor cells (CPCs)?

Answer: Not Sure Enough


Are adult tissue-resident macrophages seeded before birth?

Answer: Yes


Answer: Yes


Do adult tissue-resident macrophages possess a self-renewing capacity?

Answer: Yes


Do adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver?

Answer: Not Sure Enough


Do adult tissue-resident macrophages come from the embryonal yolk sac and fetal liver?

Answer: Not Sure Enough


Are aged patients less susceptible to ischaemia/reperfusion injury?

Answer: Not Sure Enough


Are aged patients more susceptible to ischaemia/reperfusion injury?

Answer: Not Sure Enough


Is aggravated inflammation dependent on NLRP3 inflammasome activation?

Answer: Yes


Is Albendazole used to treat soil-transmitted helminths?

Answer: Not Sure Enough


Do Algerian physicians make up the largest group of sub-Saharan Africa-trained physicians in the United States?

Answer: Not Sure Enough


Does Alirocumab treatment reduce apo(a) fractional clearance rate?

Answer: No


Is allogeneic mechanical circulatory support as effective as autologous mechanical circulatory support for treating acute myocardial infarction?

Answer: No


Does alteration of origin firing cause changes in termination zones of Okazaki fragments?

Answer: No


Is ambulatory blood pressure monitoring inaccurate at diagnosing hypertension?

Answer: No


Is Amitriptyline an effective treatment for chronic tension-type headaches?

Answer: Yes


Is an M2-like phenotype in brown adipose tissue macrophages quickly induced by cold exposure?

Answer: Yes


Can androgenetic haploid mouse embryonic stem cells be derived and genetically manipulated in vitro?

Answer: Yes


Are angiotensin converting enzyme inhibitors associated with decreased risk for functional renal insufficiency?

Answer: No


Is it true that anthrax spores are very difficult to dispose once they are dispersed?

Answer: Yes


Do anthrax spores remain deadly until affected areas are decontaminated?

Answer: Yes


Do antidepressants increase the severity of migraines?

Answer: No


Do antidepressants reduce the severity of migraines?

Answer: Yes


Is it true that antimicrobial agents are less effective due to the pressure of antimicrobial usage?

Answer: Yes


Is it a fact that antimicrobial agents are more effective due to the pressure of antimicrobial usage?

Answer: No


Does antiretroviral therapy increase rates of tuberculosis in a wide range of CD4 levels?

Answer: No


Are approximately 250,000 people infected with human T-cell lymphotropic virus type 1 in the United Kingdom?

Answer: Not Sure Enough


Is assessing treatment adherence more beneficial to clinical practice than measuring routine outcomes?

Answer: Not Sure Enough


Does screening for asymptomatic visual impairment in elderly populations lead to improved vision?

Answer: No


Do at least 85% of patients exposed to radiation have activated markers of myofibroblasts?

Answer: Not Sure Enough


Does autologous transplantation of mesenchymal stem cells have better graft function than induction therapy with anti-interleukin-2 receptor antibodies?

Answer: Yes


Does autophagy deficiency in the liver increase vulnerability to insulin resistance?

Answer: No


Do B cells undergo plasmablast differentiation and antibody production by continuously expressing EBI2?

Answer: Yes


Does B3-Galectin decrease cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR?

Answer: Not Sure Enough


Does B3-Galectin increase cell resistance to TKIs by engaging the alternate KRAS-RalB signaling complex downstream of EGFR?

Answer: Not Sure Enough


Does BCL-2 activation antagonize the apoptotic effects of c-Myc?

Answer: Yes


Does BCL-2 promote the apoptotic effects of c-Myc?

Answer: No


Does the BLM gene encode RecQ-class DNA helicase?

Answer: Yes


Does the risk of breast and ovarian cancer for BRCA 1 mutation carriers depend on the location of the mutation?

Answer: Yes


Can bacterial meningitis be diagnosed based on positive cerebrospinal fluid (CSF) cultures?

Answer: Yes


Are Bacteriophages MS2 and Qβ members of the Leviviridae?

Answer: Not Sure Enough


Does bariatric surgery increase rates of colorectal cancer?

Answer: Yes


Does bariatric surgery increase rates of postmenopausal breast cancer?

Answer: Yes


Does bariatric surgery lead to negative outcomes in mental health?

Answer: No


Does bariatric surgery lead to positive outcomes in mental health?

Answer: Yes


Does bariatric surgery reduce colorectal cancer?

Answer: No


Does bariatric surgery reduce postmenopausal breast cancer?

Answer: No


Does basophils promote disease development in patients with systemic lupus erythematosus (SLE)?

Answer: Yes


Answer: Not Sure Enough


Is beta-band coherence diminished for visible stimuli over invisible stimuli?

Answer: Not Sure Enough


Is beta-band coherence enhanced for visible stimuli over invisible stimuli?

Answer: Not Sure Enough


Is BiP a general marker for endoplasmic reticulum stress?

Answer: Not Sure Enough


Does binding of p53 to enhancer regions (p53BERs) regulate the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs?

Answer: Yes


Is birth-weight negatively associated with breast cancer?

Answer: No


Does blocking the interaction between TDP-43 and respiratory complex I proteins ND3 and ND6 prevent TDP-43-induced neuronal loss?

Answer: Yes


Is Bone Marrow transplantation used to treat acute myeloid leukemia (AML)?

Answer: Not Sure Enough


Do bone marrow cells contribute to adult macrophage compartments?

Answer: Yes


Are British female students bullied more than British male students?

Answer: Not Sure Enough


Are British male students bullied more than British female students?

Answer: Not Sure Enough


Do bnAb 10EB have any affinity for phospholipids?

Answer: Yes


Does C2 work synergistically with A-769662 to activate dephosphorylated AMPK?

Answer: Yes


Answer: Yes


Answer: Not Sure Enough


Does CD28 initiate tonic signaling in conventional T cells, causing an exhaustion phenotype and limited efficiency?

Answer: Yes


Do CD28 signals regulate the trafficking of murine auto-reactive T cells into target tissues?

Answer: Yes


Is CD44v6 associated with constitutive and reprogrammed cancer stem cells driving cancer metastasis?

Answer: No


Does CDK6 exhibit impaired binding to loss-of-function variants of p18 INK4C?

Answer: Not Sure Enough


Does CDK6 exhibit enhanced binding to loss-of-function variants of p18 INK4C?

Answer: Not Sure Enough


Is CHOP a general endoplasmic reticulum stress marker?

Answer: Not Sure Enough


Answer: Yes


Answer: Not Sure Enough


Is CRP positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery?

Answer: Not Sure Enough


Does Ca2+ cycling control whole-body energy homeostasis in beige fat?

Answer: Yes


Is Ca2+ cycling a UCP1-dependent thermogenic mechanism?

Answer: No


Is Ca2+ cycling a UCP1-independent thermogenic mechanism?

Answer: Yes


Can cancer cells promote the production of granulocyte colony stimulating factor, which results in the accumulation of intra-tumoural myeloid-derived suppressor cells?

Answer: Yes


Are cancer-associated fibroblasts constituents of tumor microenvironments?

Answer: Not Sure Enough


Is it true that cancer-associated fibroblasts (CAFs) have no known interaction with cancer cells in the formation and activation of CAFs?

Answer: Not Sure Enough


Do cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs?

Answer: Not Sure Enough


Do cancers that initially respond to epidermal growth factor receptor targeted therapies later become resistant due to various mechanisms?

Answer: Yes


Do cardiac tissue-resident macrophages directly contribute to electrical activity?

Answer: Yes


Are carriers of HNF4A mutations at reduced risk for diabetes?

Answer: Not Sure Enough


Does cell autonomous sex determination occur in somatic cells in Galliformes?

Answer: Yes


Is it true that cellular clocks are associated with mitosis timing in NIH 3T3 cells?

Answer: Yes


Are cellular clocks predictive of mitosis timing in NIH 3T3 cells?

Answer: No


Is cellular differentiation of embryonic stem cells accompanied by changes in replication timing, transcription and nuclear localization?

Answer: Yes


Are certain immunomodulator-human dialyzable leukocyte extract (hDLE) peptides recognized by toll-like receptors (TLRs) on macrophages and dendritic cells?

Answer: Not Sure Enough


Is charcoal an effective treatment for acute paraquat poisoning?

Answer: No


Does charcoal show any benefit for acute paraquat poisoning?

Answer: Yes


Does chemical injury repress transglutaminase 2 activity?

Answer: Not Sure Enough


Does treatment with Chenodeoxycholic acid decrease brown adipose tissue activity?

Answer: No


Does Chenodeoxycholic acid treatment increase brown adipose tissue activity?

Answer: Yes


Are Chinese individuals with TT homozygosity in the MTHFR gene less susceptible to strokes caused by inadequate folate intake?

Answer: Not Sure Enough


Are Chinese individuals with TT homozygosity in the MTHFR gene more susceptible to strokes caused by low levels of folate intake?

Answer: Not Sure Enough


Is Chlamydia trachomatis most prevalent in individuals in their 50s and 60s in the UK?

Answer: Not Sure Enough


Is Chlamydia trachomatis most prevalent in the UK among sexually-experienced individuals aged 16 to 24?

Answer: Yes


Does cholesterol loading induce KLF4 expression in VSMCs, resulting in the expression of pro-inflammatory cytokines?

Answer: Yes


Does chronic HIV stimulation lead to the premature exhaustion of B cells?

Answer: Not Sure Enough


Do cis-acting lncRNAs control the expression of genes that are positioned in the vicinity of their transcription sites?

Answer: Not Sure Enough


Do citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle?

Answer: No


Does the externalization of citrullinated proteins in neutrophil extracellular traps perpetuate the inflammatory cycle indirectly by inducing autoantibodies?

Answer: Yes


Does clathrin stabilize the spindle fiber apparatus during mitosis?

Answer: Yes


Does CNN1 recruitment vary with cell cycle timing?

Answer: Yes


Is cognitive behavioral therapy an ineffective treatment for insomnia?

Answer: No


Is combination therapy of nicotine replacement therapies with varenicline or bupropion more effective after 12 weeks of treatment compared to varenicline monotherapy?

Answer: Yes


Does Commelina yellow mottle virus (ComYMV) have three typical badnavirus ORFs that are capable of encoding proteins with sizes of 23, 15, and 216 kD?

Answer: Yes


Does Commelina yellow mottle virus have a genome consisting of 2140 base pairs?

Answer: No


Did comparative transcriptome analysis identify new platelet proteins with structural features suggesting a role in platelet function?

Answer: Yes


Are the concentrations of SNV and CNV in stem-cell regulatory elements and binding sites of transcription factors in iPSC-lines distinct from their founding cells?

Answer: Not Sure Enough


Does consumption of whole fruits increase the risk of type 2 diabetes?

Answer: No


Can the continued transmission of HHV-8 among MSM in San Francisco be explained by urogenital contact?

Answer: Not Sure Enough


Does converting apoE4 to apoE3 via gene editing prevent the pathology associated with apoE4 in human iPSC-derived neurons?

Answer: Yes


Does converting apoE4 to apoE3 through gene editing worsen the pathology associated with apoE4 in human iPSC-derived neurons?

Answer: No


Does cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice?

Answer: No


Does cost effectiveness evaluations based on cRCT data lack external validity?

Answer: Yes


Are crossover hot spots found within gene promoters in Saccharomyces cerevisiae?

Answer: Not Sure Enough


Is Cyclin A2 destruction necessary to switch from unstable to stable kt-mt attachments in mitosis?

Answer: Yes


Is cytochrome c transferred from cytosol to the mitochondrial intermembrane space during apoptosis?

Answer: No


Do cytosolic proteins bind to iron-responsive elements on mRNAs encoding TFRC1?

Answer: Not Sure Enough


Does DMS3 protein enable Pol V transcription in vivo?

Answer: Not Sure Enough


Do DRD1 proteins enable Pol V transcription in vivo?

Answer: Yes


Answer: No


Does downregulation of DUSP4 deactivate the Ras-ERK pathway?

Answer: No


Answer: Yes


Does de novo assembly of sequence data have fewer specific contigs than unassembled sequence data?

Answer: Not Sure Enough


Does de novo assembly of sequence data have shorter contigs than unassembled sequence data?

Answer: Not Sure Enough


Does the decrease of p62 in prostate tumor stroma result in defective autophagy?

Answer: Not Sure Enough


Does decreased conversion of PGE2 to PPARy ligand 15-ket-PGE2 cause accumulation of PGE?

Answer: Not Sure Enough


Is decreased diastolic blood pressure (DBP) associated with abdominal aortic aneurysm?

Answer: No


Does deleting Raptor increase G-CSF levels?

Answer: Not Sure Enough


Is deletion of ATM and Rad3 related protein predictive of acute tissue loss?

Answer: Not Sure Enough


Does deletion of ATM and Rad3 related protein lead to acute tissue loss?

Answer: Not Sure Enough


Does Deltex have any known interactions with eIF3f?

Answer: No


Is there any known interaction between Deltex and elF3, considering that Deltex interacts with eIF3?

Answer: No


Does depletion of T-helper 17 (Th17) cells during SIV infection result in decreased dissemination of Salmonella Typhimurium from the gut?

Answer: No


Does depletion of T-helper 17 (Th17) cells during SIV infection increase dissemination of Salmonella Typhimurium from the gut?

Answer: Yes


Is depletion of nitric oxide responsible for vasospasm?

Answer: Yes


Is deregulation of HAND2 a crucial step in endometrial carcinogenesis in mice?

Answer: Yes


Is destination container port throughput (CPT) negatively related to the diffusion of dengue virus (DENV-1) in air traffic shipments?

Answer: Not Sure Enough


Is there a positive relationship between Destination container port throughput (CPT) and diffusion of Dengue virus (DENV-1) in air traffic shipments?

Answer: Not Sure Enough


Does dexamethasone increase the risk of postoperative bleeding?

Answer: Yes


Does diabetes remission occur less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery?

Answer: Yes


Does diabetes remission occur more in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery?

Answer: No


Do diabetic patients with acute coronary syndrome experience a decreased risk for bleeding events both in the short-term and long-term?

Answer: No


Do differentiated E2f-1, -2, -3 TKO cells in the intestine exhibit apoptosis?

Answer: Not Sure Enough


Does activation of insulin signaling skew differentiation of progenitor cells to myeloid cells?

Answer: No


Is the differentiation of progenitor cells to myeloid cells skewed when insulin signaling is suppressed?

Answer: Yes


Is diminished ovarian reserve a reliable indicator of infertility in a non-infertile population?

Answer: No


Is it true that distant CREs are important for transcriptional regulation?

Answer: Not Sure Enough


Is it true that distant CREs are less conserved among species?

Answer: Not Sure Enough


Are Drosophila supracellular actomyosin structures found at boundaries in wing imaginal discs?

Answer: Yes


Does Dscam1 act as a hypervariable pattern-recognition receptor for the immune system?

Answer: Yes


Is it true that during non-homologous end joining, the ligation step is less tolerant of disrepairs and other distortions when joining 3' of strand breaks than 5' strand breaks?

Answer: Not Sure Enough


Is the ligation step during non-homologous end joining less tolerant of disrepairs and other distortions when joining 5' of strand breaks compared to 3' strand breaks?

Answer: Not Sure Enough


Do activated B cells migrate towards the inner and outer follicular areas where oxysterol accumulation is generated by stromal cells during the primary early antibody response?

Answer: Not Sure Enough


Can systemic oxaliplatin primed CD8+ T cells from the tumor-draining lymph node cells kill EG7 tumors?

Answer: Not Sure Enough


Is EGR2 important for myelination of the peripheral nervous system?

Answer: Not Sure Enough


Does the ER-localized phosphatase Sac1 process PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2?

Answer: Not Sure Enough


Are ERAP1 SNPs epistatic to HLA alleles for ankylosing spondylitis?

Answer: Yes


Does early screening for patent ductus arteriosus (PDA) reduce in-hospital mortality?

Answer: Yes


Does early patent ductus arteriosus (PDA) screening increase in-hospital mortality?

Answer: No


Does ectopic expression of Sall4, Nanog, Esrrb, and Lin28 generate induced pluripotent stem cells from mouse embryonic fibroblasts more efficiently compared to other factor combinations?

Answer: Yes


Does Egr2 regulate the homeostasis of B and T cells?

Answer: Yes


Does Egr3 regulate the homeostasis of B and T cells?

Answer: Yes


Does Eilat virus (EILV) produced in mosquitos elicit rapid and long-lasting neutralizing antibodies in nonhuman primates?

Answer: Yes


Are elevated cell-free mitochondrial DNA levels associated with mortality?

Answer: Yes


Does eliminating the last sporadic cases of malaria require considerable funding?

Answer: Not Sure Enough


Does emodin form hydrogen bonds with residues involved in PGAM1 substrate binding?

Answer: Not Sure Enough


Does energy balance require hypothalamic glutamate neurotransmission?

Answer: Yes


Does enhanced early production of inflammatory chemokines damage viral control in the lung?

Answer: No


Can environmental factors influence the development of breast cancer?

Answer: Yes


Is environmentally-induced senescence mimicked in disease modeling by adding specific molecules to the culture system?

Answer: Yes


Is the epidemiological disease burden from noncommunicable diseases more prevalent in high economic settings?

Answer: Not Sure Enough


Does ethanol stress increase the expression of IBP in bacteria?

Answer: Not Sure Enough


Does ethanol stress increase the expression of PSP in bacteria?

Answer: Not Sure Enough


Does ethanol stress increase the expression of SRL in bacteria?

Answer: Not Sure Enough


Does ethanol stress lower the expression of PSP in bacteria?

Answer: Not Sure Enough


Does ethanol stress reduce the expression of SRL in bacteria?

Answer: Not Sure Enough


Is excess gestational weight gain associated with obesity-related pregnancy outcomes?

Answer: Yes


Does exercise increase cancer mortality rates among Chinese citizens?

Answer: No


Does exercise reduce cancer mortality rates among Chinese citizens?

Answer: Yes


Does exhaustion of B cells contribute to poor antibody response in HIV-infected individuals?

Answer: Not Sure Enough


Is exposure to fine particulate air pollution unrelated to anxiety prevalence?

Answer: No


Is the expression of MSX2 induced earlier than T and CDX2 after the addition of BMP4?

Answer: Not Sure Enough


Does expression of oncolytic virus antigens as peptides make relapse more likely?

Answer: Not Sure Enough


Does expression of oncolytic virus antigens as peptides provide additional protection against relapse?

Answer: Not Sure Enough


Do F4/80+ macrophages regulate mature osteoblast maintenance?

Answer: Not Sure Enough


Does FACT and other histone chaperones compensate for the eviction of Histone 2A (H2A)-histone 2B (H2B) dimers during the histone exchange process?

Answer: Not Sure Enough


Do female carriers of the Apolipoprotein E4 (APOE4) allele have a decreased risk for dementia?

Answer: No


Do female carriers of the Apolipoprotein E4 (APOE4) allele have an increased risk for Alzheimer's disease?

Answer: Yes


Do female carriers of the Apolipoprotein E4 (APOE4) allele have longer lifetime exposure to estrogen due to an increased reproductive period?

Answer: Yes


Do female carriers of the Apolipoprotein E4 (APOE4) allele have a shorter lifetime exposure to estrogen due to a decreased reproductive period?

Answer: No


Does Fibroblast Growth Factor signal through receptor tyrosine kinases?

Answer: Not Sure Enough


Does fibroblast growth factor 21 protect against atherosclerosis by modulating adiponectin and SREBP2 levels?

Answer: Yes


Do flexible molecules experience less steric hindrance in the tumor microenviroment than rigid molecules?

Answer: Not Sure Enough


Do folate and vitamin B12 levels influence the association between homocysteine and preeclampsia?

Answer: Not Sure Enough


Do more than 300 of every 1,000 children with cerebral palsy have a history of being premature or underweight at birth?

Answer: Not Sure Enough


Are forkhead 0 (fox0) transcription factors involved in apoptosis?

Answer: Yes


Are Forkhead 0 (fox0) transcription factors involved in cellular differentiation?

Answer: Yes


Does glutamine cyclase (GC) compete with NTAQ1 for Nt-Gln substrates by forming N-terminal pyroglutamate?

Answer: Not Sure Enough


Is FoxO3a activation inhibited by reactive oxygen species (ROS) in neuronal death?

Answer: No


Does Foxk2 regulate autophagy genes in both muscle cells and fibroblast cells?

Answer: Yes


Does Foxp3 facilitate the expression of transcriptional regulators involved in the development of memory T cells?

Answer: Not Sure Enough


Does Foxp3 repress the expression of transcriptional regulators involved in memory T cell development?

Answer: Not Sure Enough


Does G-CSF increase the expansion and infiltration of MDSCs into tumors?

Answer: Yes


Does GATA3 regulate cell cycle progression in bone marrow hematopoietic stem cells?

Answer: Yes


Does GATA3 regulate self-renewal capacity in bone marrow hematopoietic stem cells?

Answer: Yes


Does gastric infection with Helicobacter pylori decrease the risk of gastric cancer in humans?

Answer: No


Does gastric infection with Helicobacter pylori increase the risk of gastric cancer in humans?

Answer: Yes


Is gastric lavage an effective treatment for acute paraquat poisoning?

Answer: Not Sure Enough


Is general exercise therapy more effective than rotator cuff exercises in reducing pain and improving function of the shoulder?

Answer: No


Is general exercise therapy more effective than scapular stabilizer exercises in reducing pain and improving function of the shoulder?

Answer: No


Does genes involved in pre-mRNA splicing have a significant impact on genome stability?

Answer: Yes


Are genes regulated by Esrrb transcription factor sensitive to Mbd3 function?

Answer: Not Sure Enough


Does a genetic deficiency of mast cells result in reduced weight gain in a mouse model of diet-induced obesity?

Answer: Yes


Does genetic deletion of JAM-A increase gut permeability?

Answer: Yes


Do genomic aberrations of metastases provide information for targeted therapy?

Answer: Yes


Are the genomic sequences involved in alternative splicing responsible for Hutchinson-Gilford progeria syndrome abundant in the "progerinonly" allele of Lmna knock-in models?

Answer: No


Do glial calcium waves influence seizures?

Answer: Yes


Is Glioblastoma multiforme (GBM) characterized by extensive invasion, rapid growth, necrosis, and angiogenesis?

Answer: Yes


Does reducing glucose to 0.05% decrease the replicative life span by 20-40% in S. cerevisiae?

Answer: Not Sure Enough


Does glycan adaptation involve insertion-deletion events?

Answer: Not Sure Enough


Is glycan adaptation commonly observed in the B-cell repertoire?

Answer: Not Sure Enough


Does Gpr124 increase BBB breakdown in mouse models of ischemic stroke?

Answer: No


Does Gpr124 suppress BBB breakdown in mouse models of ischemic stroke?

Answer: Yes


Does Guanine nucleotide dissociation inhibitor (Rho-GDI) interact with the p75 NTR death domain?

Answer: Not Sure Enough


Do guanine nucleotide exchange factors (GEFs) mediate RhoA activation in response to tensional forces on fibronectin-binding integrins?

Answer: Yes


Does H.pylori-mediated gastric cancer occur due to the accumulation of mutations in host epithelial cells?

Answer: Yes


Do H4 G94P proteins induce chromatin assembly, which results in an increase of free histones?

Answer: Not Sure Enough


Do H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms?

Answer: Not Sure Enough


Do H4 G94P proteins inhibit chromatin assembly, which results in a decrease of free histones?

Answer: Not Sure Enough


Does the H4 G94P protein suppress the degradation of free histones through Rad53-dependent mechanisms?

Answer: Not Sure Enough


Is HAND2 methylation a key step in early endometrial carcinogenesis?

Answer: Yes


Does the HIV trans-activator protein (TAT) effectively transport large and small molecules across cellular membranes into larger populations of neurons?

Answer: Not Sure Enough


Are HNF4A mutations associated with macrosomia in infancy?

Answer: Not Sure Enough


Does HOXB4 facilitate HSC expansion when co-cultured with HSCs?

Answer: Not Sure Enough


Is HOXB4 a highly expressed component of cellular secretome from fetal liver cell populations?

Answer: Not Sure Enough


Would HSCT-T dosage be diagnostic if the onset of symptoms occurs less than 3 hours before AMI?

Answer: Not Sure Enough


Does having a main partner improve HIV outcomes?

Answer: Yes


Does having a main partner worsen HIV outcomes?

Answer: No


Does HbA1c consistently overestimate glycemic control in black individuals with Sickle cell trait (SCT)?

Answer: No


Is there a correlation between headaches and cognitive impairment?

Answer: No


Do healthy volunteers exhibit a rapid and transient increase of cellular ATP after being bolus-injected with fructose?

Answer: No


Does the aberrant NF-kB-dependent expression of activation-induced cytidine deaminase induced by Helicobacter pylori contribute to the mutagenesis of host DNA?

Answer: Yes


Do helminths interfere with the immune system's control of coinfections by microbial pathogens?

Answer: Yes


Does Hematopoietic Stem Cell purification reach purity rates above 90%?

Answer: Not Sure Enough


Does high levels of CRP increase the risk of exacerbations in chronic obstructive pulmonary disease (COPD)?

Answer: Yes


Is there a negative correlation between higher plasma levels of I-carnitine and cardiovascular events in humans when associated with trimethylamine N-oxide?

Answer: No


Are higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, positively correlated with cardiovascular events in humans?

Answer: Yes


Does the homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells induce oxidative stress?

Answer: Not Sure Enough


Do human embryonic stem cells give rise to cell types from all three embryonic germ layers?

Answer: Yes


Do human embryonic stem cells give rise to cell types from only the outer embryonic germ layer but not from the other two layers?

Answer: No


Do human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers?

Answer: Yes


Do hypocretin neurons suppress panic-prone state in rats?

Answer: No


Is hypothalamic glutamate neurotransmission related to energy balance?

Answer: No


Does IFI16 impede STING phosphorylation and translocation, resulting in reduced activation of STING?

Answer: No


Does IFIT1 enhance viral replication by promoting the growth of mis-capped viral RNAs?

Answer: Not Sure Enough


Does the production of IL-10 by monocytes inhibit CD4+ T cell response?

Answer: Yes


Does IL-6 signaling play a major role in atherosclerotic cardiovascular disease?

Answer: Yes


Does ITAM phosphorylation enable the transfer of the TCR signal from the echo-domain to the cytoplasmic tail of the TCR?

Answer: Not Sure Enough


Are IgA plasma cells that are specific for transglutaminase 2 scarce in the duodenal mucosa of celiac disease patients when the disease is active?

Answer: No


Does immune complex triggered cell death lead to extracellular release of nuclear DNA?

Answer: Not Sure Enough


Does immune complex-triggered cell death result in the sequestration of oxidized mitochondrial DNA?

Answer: Not Sure Enough


Are immune responses geographically segregated within immune cells?

Answer: Yes


Do improvements in OER catalysts show stable activity over several hundred hours?

Answer: Yes


Does haplogroup I decrease the risk of cardiovascular disease in British men?

Answer: No


Does haplogroup I increase the risk of cardiovascular disease by 50% in British men?

Answer: Yes


Does the absence of RNA surveillance pathways in S. cerevisiae cause sensitivity to high iron conditions?

Answer: Yes


Does the absence of RNA surveillance pathways in S. cerevisiae reduce sensitivity to high iron conditions?

Answer: No


Does blocking Wingless-Int-1 secretion from mouse embryonic stem cells inhibit their self-renewal?

Answer: Yes


Does the loss of myoepithelial cells promote the transition of ductal carcinoma in situ to invasive carcinoma in breast cancer?

Answer: Yes


Does the loss of myoepithelial cells slow the transition of ductal carcinoma in situ to invasive carcinoma in breast cancer?

Answer: No


Can peptides that selectively inhibit PTPRS be used to boost insufficient activity of pDCs in chronic viral infections or tumors?

Answer: Not Sure Enough


Is segmental aneuploidy very common in domesticated populations of Saccharomyces cerevisiae?

Answer: Not Sure Enough


Does segmental aneuploidy occur frequently in domesticated populations of Saccharomyces cerevisiae?

Answer: Not Sure Enough


Does anti-CTLA-4 treatment reinvigorate exhausted PD-1+Eomes+CD8 T cells in melanoma?

Answer: Yes


Do β-blockers significantly improve clinical heart failure outcomes in patients with congenital heart defects?

Answer: No


Are most T cells in pediatric tissue naive T cell emigrants from the thymus?

Answer: Yes


Is daily subcutaneous injection of emtricitabine effective in protecting against rectally transmitted simian-human immunodeficiency virus in rhesus macaques?

Answer: Not Sure Enough


Does daily subcutaneous injections of tenofovir protect against rectally transmitted simian-human immunodeficiency virus in rhesus macaques?

Answer: Yes


Does drowning affect boys and girls equally in the UK?

Answer: Not Sure Enough


Do more than 50 percent of the cells that colocalize with cell proliferation markers in transgenic mice harbor green fluorescent protein under the control of the Sox2 promoter?

Answer: Not Sure Enough


Does the use of ADHD medications in young and middle-aged adults, whether current or remote, increase the risk of serious cardiovascular events?

Answer: No


Is the incidence of 10/66 dementia higher than the incidence of DSM-IV dementia?

Answer: Yes


Is the incidence of 10/66 dementia lower than the incidence of DSM-IV dementia?

Answer: No


Did the incidence of heart failure increase by 10% in women since 1979?

Answer: No


Has the incidence of sepsis fallen substantially from 2009 to 2014?

Answer: No


Does including pharmacists in rounding teams alter the incidence of adverse drug events (ADEs)?

Answer: No


Does including pharmacists in rounding teams reduce the incidence of adverse drug events (ADEs)?

Answer: Yes


Does an increase of p62 in prostate tumor stroma result in defective autophagy?

Answer: Not Sure Enough


Does increased LDL receptors play a role in reducing plasma Lp(a)?

Answer: Yes


Does increased conversion of PGE2 to PPARy ligand 15-ket-PGE2 cause accumulation of PGE?

Answer: Not Sure Enough


Is increased diastolic blood pressure (DBP) associated with abdominal aortic aneurysm?

Answer: Yes


Does an increased flux of microbial products provoke immune responses?

Answer: Not Sure Enough


Does an increased flux of microbial products suppress immune responses?

Answer: Not Sure Enough


Does increased lipolysis lead to higher P38 phosphorylation in adipose tissue?

Answer: Not Sure Enough


Does increased microtubule acetylation exacerbate LRRK2 Roc-COR domain mutation induced locomotor deficits?

Answer: No


Does increased microtubule acetylation repair interference of axonal transport caused by LRRK2 Roc-COR domain mutations?

Answer: Yes


Does increased microtubule acetylation worsen interference of axonal transport caused by LRRK2 Roc-COR domain mutations?

Answer: No


Does increased mobility of retrotransposons lead to mutation and higher tumorigenesis rates?

Answer: Not Sure Enough


Is increased mobility of retrotransposons associated with mutation and higher tumorigenesis rates?

Answer: Not Sure Enough


Does the increased purity of cytoplasmic membranes isolated from overexpressors result in stronger spots for OmpF in 2D BN-PAGE gels?

Answer: Not Sure Enough


Does an increase in vessel density and a reduction in fibrosis improve the efficacy of chemotherapy treatments?

Answer: Not Sure Enough


Does participating in six months of physical activity improve cognitive function for up to 18 months in individuals with Alzheimer's?

Answer: Yes


Do individuals with low serum vitamin D concentrations have a decreased risk of multiple sclerosis?

Answer: Not Sure Enough


Do induced hepatic stem cells have the potential to differentiate into cholangiocytic cells?

Answer: Yes


Do induced hepatic stem cells have the potential to differentiate into hepatocytic cells?

Answer: Yes


Does induction of urokinase receptor signaling in podocytes cause foot process effacement and proteinuria?

Answer: Yes


Does inhibiting HDAC6 increase survival of mice with ARID1A mutated tumors?

Answer: Yes


Does inhibiting focal adhesion formation enable cells to convert mechanical strain into eventual scarring?

Answer: No


Does inhibiting focal adhesion formation result in an increased rate of converting mechanical strain into inflammation and fibrosis in cells?

Answer: No


Does inhibiting glucose-6-phosphate dehydrogenase improve lipogenesis by deactivating LKB1-AMPK signaling?

Answer: No


Is input from mental and physical health care professionals effective at decreasing homelessness?

Answer: Not Sure Enough


Do falciparum parasites reproduce asexually inside the body?

Answer: Yes


Does insulin decrease the risk of severe kidney failure?

Answer: Not Sure Enough


Does insulin affect appetite through ventral tegmental neurons?

Answer: Yes


Does intake of folic acid (FA) and vitamin B6 (VB6) increase levels of homocysteine?

Answer: No


Does intake of folic acid (FA) and vitamin B6 (VB6) reduce levels of homocysteine?

Answer: Yes


Is integrated care effective at tackling multiple comorbidities?

Answer: No


Is integrated care successful at tackling multiple comorbidities?

Answer: Yes


Does integrating classroom-based collaborative learning with Web-based collaborative learning offer the best class performance?

Answer: Not Sure Enough


Do Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons?

Answer: Not Sure Enough


Do Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 inhibit West Nile virus replication in cortical neurons?

Answer: Not Sure Enough


Does interleukin-18 play an important role in the pathogenesis of atherosclerosis?

Answer: Yes


Does infusion of amyloid-β oligomers into the ventricles of mice increase the expression of fibronectin type-III domain-containing protein 5 mRNA in the hippocampi?

Answer: Not Sure Enough


Does intra-cerebroventricular infusion of amyloid-β oligomers reduce the expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi?

Answer: Not Sure Enough


Does intramembrane cleavage by signal peptide peptidase aid in the degradation of proteins with a complex membrane orientation?

Answer: Yes


Is it proven that moderate consumption of candy and chocolate reduces the risk of cardiovascular disease (CVD) specifically?

Answer: Not Sure Enough


Does JMJD6 catalyze the hydroxylation of C-terminal lysine and suppress transcriptional activity?

Answer: Yes


Does JMJD6 slow down the hydroxylation of C-terminal lysine?

Answer: No


Is KLF4 necessary for VSMCs to acquire genetic traits of other cell types within atherosclerotic lesions?

Answer: Yes


Does KRT17 modulate the expression of the transcriptional regulator AIRE in diseased epithelia?

Answer: Yes


Does Kir7.1 modulate channel activity by the G protein-coupled melanocortin-4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus?

Answer: Yes


Is Klf2 important for proper myeloid cell function?

Answer: Yes


Is Klf4 important for proper myeloid cell differentiation?

Answer: Yes


Is Klf4 necessary for proper myeloid cell differentiation?

Answer: No


Does knockout proximal tubule-specific deletion of the BMP receptor Alk3 cause epithelial damage?

Answer: Yes


Does knockout proximal tubule-specific deletion of the BMP receptor Alk3 cause fibrosis?

Answer: Yes


Does L3MBTL2 bind to H2AK119Ub marked chromatin to form a PRC1 complex?

Answer: Not Sure Enough


Does LDL cholesterol have a causal role in the development of cardiovascular disease?

Answer: Yes


Answer: Not Sure Enough


Answer: Not Sure Enough


Are LSD1-positive promoters associated with RNA polymerase II?

Answer: Not Sure Enough


Does the lack of FGF21 in mice increase life expectancy?

Answer: No


Does the lack of FGF21 in mice lead to atherosclerotic plaque formation?

Answer: Yes


Does the lack of FGF21 in mice lead to reduced lifespan?

Answer: Yes


Does the lack of FGF21 in mice slow the rate of atherosclerotic plaque formation?

Answer: No


Are lamins associated with nuclear membrane structure maintenance?

Answer: Not Sure Enough


Are lamins found within the inner layer of the mitochondrial membrane of all cells?

Answer: Not Sure Enough


Are lamins found within the inner layer of the nuclear membrane of all cells?

Answer: Not Sure Enough


Does lamin have any effect on maintenance of nuclear membrane structure?

Answer: Not Sure Enough


Do less than 10% of patients exposed to radiation have activated markers of mesenchymal stem cells?

Answer: Not Sure Enough


Do lice attenuated SIV vaccines induce a stronger antigen-specific T cell response in lymph node cells?

Answer: Yes


Does lipopolysaccharides have an inflammation independent effect on kidney barrier function?

Answer: Not Sure Enough


Is it appropriate to use LMNA knock-in models for testing therapeutic approaches against Hutchinson-Gilford Progeria Syndrome (HGPS)?

Answer: Not Sure Enough


Does localization of PIN1 in the roots of Arabidopsis require VPS9a?

Answer: Not Sure Enough


Do long-range chromatin interactions regulate transcription?

Answer: Not Sure Enough


Does supplementation of long chain polyunsaturated fatty acids have significant effects on wheezing or asthma at 3 and 6 years?

Answer: Not Sure Enough


Is long chain polyunsaturated fatty acids supplementation associated with lower rates of atopic eczema at 1 year?

Answer: Yes


Does supplementation of long chain polyunsaturated fatty acids reduce wheezing and asthma?

Answer: Not Sure Enough


Does low expression of miR7a repress target genes or exert a biological function in ovaries?

Answer: Not Sure Enough


Does low expression of miR7a repress target genes or exert a biological function in the testis?

Answer: Not Sure Enough


Does low nucleosome occupancy correlate with high methylation levels across species?

Answer: Yes


Does Ly49Q regulate membrane raft functions to direct the organization of neutrophil polarization?

Answer: Yes


Do Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes?

Answer: Yes


Is JIB 04 inactive against KDM5A, a lysine histone demethylase?

Answer: Not Sure Enough


Does M. stadtmanae induce ASC speck formation in BlaER1 monocytes?

Answer: Not Sure Enough


Answer: Not Sure Enough


Are MEK inhibitors effective treatments in RAS-driven mouse models of cancer?

Answer: Yes


Does MFGE8 regulate fat absorption by binding to av-Beta3 and av-Beta5 integrins?

Answer: Yes


Do MICAL redox enzymes regulate actin dynamics in many cell types?

Answer: Yes


Do MICAL redox enzymes regulate actin dynamics?

Answer: Yes


Does the MT binding domain drive amyloid structure formation?

Answer: Not Sure Enough


Does MUC1-C activate the NF-κB p65 signaling pathway by interacting with IκB kinase ß?

Answer: Yes


Does phosphorylation of MafA reduce its ubiquitination?

Answer: No


Does phosphorylation of MafA enhance its ubiquitination?

Answer: Yes


Does MafA ubiquitination decrease the recruitment of coactivator P/CAF by MafA?

Answer: No


Does MafA ubiquitination increase the recruitment of coactivator P/CAF by MafA?

Answer: Yes


Are the major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors required for T cell activation?

Answer: Yes


Does MVP regulation of sorting tumor suppressive miR-193a into extracellular vesicles result in more aggressive tumors?

Answer: Yes


Does major vault protein regulate the sorting of tumor suppressive miR-193a into EVs?

Answer: Yes


Does malaria have a high vectorial capacity?

Answer: Not Sure Enough


Do many cytokines produced by cancer cells also contribute to carcinogenesis?

Answer: Not Sure Enough


Do many transmembrane receptors transmit signals by long-range conformational changes in the association of alpha-helices across the plasma membrane?

Answer: Not Sure Enough


Does Marmosets have a brain region homologous to Broca's area?

Answer: Not Sure Enough


Do mathematical models predict that using Artemisinin-based combination therapy over nongametocytocidal drugs only have a modest impact in reducing malaria transmission?

Answer: Yes


Does MeCP2 have an influence on the synaptic maturation of neurons?

Answer: Not Sure Enough


Is measuring routine outcomes more beneficial to clinical practice than assessing treatment adherence?

Answer: Not Sure Enough


Is it true that medications to treat obesity are highly effective?

Answer: No


Do medications to treat obesity have any side effects?

Answer: No


Do medications to treat obesity have unwanted side effects?

Answer: Yes


Are men more susceptible to death due to pneumonia when compared to women?

Answer: No


Did the treatment of metastatic colorectal cancer with a single agent fluoropyrimidines result in similar efficacy and better quality of life as compared to oxaliplatin-based chemotherapy in elderly patients?

Answer: No


Are mice able to produce neutralizing antibodies in response to Chikungunya virus (CHIKV) produced in mosquitos?

Answer: No


Does the absence of DNA polymerase I (polI) in mice result in increased sensitivity to ionizing radiation (IR)?

Answer: Not Sure Enough


Does the absence of DNA polymerase m (polm) in mice result in a failure to show increased sensitivity to ionizing radiation (IR)?

Answer: Not Sure Enough


Does the sensitivity to ionizing radiation (IR) increase in mice that are defective for Deoxyribonucleic acid (DNA) polymerase m (polm)?

Answer: Not Sure Enough


Does the lack of Sirt1 in Sf1-expressing neurons make mice immune to diet-induced obesity and insulin resistance?

Answer: No


Do mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance?

Answer: Yes


Are mice that lack Interferon-γ or its receptor highly susceptible to experimental autoimmune myocarditis?

Answer: Yes


Are mice without IFN-γ or its receptor highly susceptible to EAM induced with α-MyHC/CFA?

Answer: Yes


Does Microcin J25 encourage nucleoside triphosphate (NTP) binding?

Answer: No


Does Microcin J25 inhibit nucleoside triphosphate (NTP) binding?

Answer: Yes


Are microglia an innate immune cell type of the central nervous system?

Answer: Yes


Are microglia an innate immune cell type of the peripheral nervous system?

Answer: No


Is migraine with aura associated with ischemic stroke?

Answer: Yes


Can misunderstandings between doctors and patients lead to non-adherence?

Answer: Yes


Do mitochondria play a major role in apoptosis?

Answer: Yes


Do mitochondria play a major role in energy production?

Answer: Yes


Does mitochondria play a trivial role in calcium homeostasis?

Answer: No


Does moderate consumption of candy and chocolate reduce the risk of cardiovascular disease (CVD)?

Answer: Not Sure Enough


Does monoclonal antibody targeting of N-cadherin encourage castration resistance?

Answer: No


Does monoclonal antibody targeting of N-cadherin promote metastasis?

Answer: No


Does monoclonal antibody targeting of N-cadherin inhibit castration resistance?

Answer: Yes


Does targeting monoclonal antibody to N-cadherin inhibit growth?

Answer: Yes


Is it true that most termination events in Okazaki fragments are dictated by initiation patterns?

Answer: Yes


Can mouse models be generated using "artificial spermatids"?

Answer: Yes


Do mutant mice that lack SVCT2 have reduced levels of ascorbic acid in both their brain and adrenals?

Answer: Yes


Are mutations in G-Beta protein GNB1 present in many cancers, resulting in loss of interaction with G-alpha subunits and activation of AKT pathway?

Answer: Not Sure Enough


Do mutations in RIM1 decrease levels of IME1 RNA?

Answer: Yes


Do mutations in RIM1 raise levels of IME1 RNA?

Answer: No


Are myelin sheaths lipid-rich cellular structures?

Answer: Not Sure Enough


Do myelin sheaths play a role in action potential propagation?

Answer: Yes


Does the N348I mutation cause resistance to nevirapine?

Answer: Yes


Does the N348I mutation decrease resistance to nevirapine?

Answer: No


Does NAC destabilize NO to enhance the impact of contrast agents on renal functions?

Answer: Not Sure Enough


Does NAC inhibit the generation of angiotensin-converting enzyme?

Answer: Not Sure Enough


Does NR5A2 play a role in the development of endometrial tissues?

Answer: No


Is NR5A2 important in reverse cholesterol transport in humans?

Answer: Not Sure Enough


Does the increase of natriuretic peptides lead to higher susceptibility to diabetes?

Answer: No


Does the claim state that natriuretic peptides protect against diabetes?

Answer: Yes


Does the Neutrophil extracellular trap (NET) antigens contain the targeted autoantigens PR3 and MPO?

Answer: Yes


Do neutrophils produce IL-1β in response to large particles?

Answer: Yes


Do Nigerian physicians constitute the largest component of sub-Saharan Africa-trained physicians in the United States?

Answer: Not Sure Enough


Are nonhuman primates able to produce neutralizing antibodies in response to the Eilat virus (EILV) produced in mosquitos?

Answer: No


Do nonhypertensive people who are 55 years old have a 90% chance of developing hypertension during their lifetime?

Answer: Yes


Is noninvasive positive pressure ventilation predictive of acute respiratory failure after solid organ transplantation?

Answer: No


Are nonsteroidal anti-inflammatory drugs effective as cancer treatments?

Answer: No


Do nonsteroidal anti-inflammatory drugs demonstrate potential indications for anticancer properties?

Answer: Yes


Does normal expression of RUNX1 cause tumor suppressing effects?

Answer: Yes


Does normal granuloma formation occur in the absence of TNF in Zebrafish?

Answer: Yes


Does normal granuloma formation occur in the presence of TNF in Zebrafish?

Answer: No


Does Notch signaling occur between tumor cells and stromal cells?

Answer: Yes


Can nuclear transfer from adult human fibroblasts to human oocytes produce blastocysts containing expandable pluripotent cells?

Answer: Not Sure Enough


Do oat tolerant coeliac patients have oat specific inflammatory cells in their small bowel mucosa?

Answer: Yes


Answer: Not Sure Enough


Answer: Not Sure Enough


Are occipital activation levels associated with auditory spatial performance in parietal regions of the brain?

Answer: Not Sure Enough


Do omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans?

Answer: No


Do omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans?

Answer: Yes


Do omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegetarians?

Answer: Yes


Are one in five surgical randomized controlled trials discontinued early?

Answer: Yes


Is it true that one in two surgical randomized controlled trials are discontinued early?

Answer: No


Is origin gross domestic product (GDP) negatively related to the diffusion of dengue virus (DENV-1) in air traffic shipments?

Answer: Not Sure Enough


Is there a positive relationship between the origin gross domestic product (GDP) and the diffusion of Dengue virus (DENV-1) through air traffic shipments?

Answer: Not Sure Enough


Do osteocytes have an essential role in G-CSF induced HSPC mobilization?

Answer: Yes


Is Osteoarthritis characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia?

Answer: Not Sure Enough


Does over half of Gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) have a plasma lactate of more than 5mmol/L?

Answer: Not Sure Enough


Does overexpression of Cnp1 N-tail variants exacerbate the temperature-sensitive growth defect of scm3-139?

Answer: Not Sure Enough


Does overexpressing Cnp1 N-tail variants rescue the temperature-sensitive growth defect of scm3-139?

Answer: Not Sure Enough


Does oxidative DNA damage activate STING signalling?

Answer: Not Sure Enough


Does oxidative DNA damage inhibit STING signalling?

Answer: Not Sure Enough


Is oxidative phosphorylation one of the primary glycometabolic pathways in cells?

Answer: Not Sure Enough


Does PCSK9 inhibitor reduce plasma Lp(a) levels?

Answer: Yes


Does PD-1 triggering on monocytes enhance IL-10 production by monocytes?

Answer: Yes


Does PGE2 suppress intestinal tumor growth by altering the expression of tumor suppressing and DNA repair genes?

Answer: Not Sure Enough


Does PGK-la have a large impact on the expression of pain hypersensitivity in PGK-la knockout mice?

Answer: No


Does PKG-la have a large impact on expression of spinal long term potentiation in PGK-la knockout mice?

Answer: No


Does PKG-la play an essential role in the expression of spinal long term potentiation in PGK-la knockout mice?

Answer: Yes


Do PRC1-bound plasmids sediment at a slower rate than unbound plasmids in sucrose gradients?

Answer: Not Sure Enough


Is PTEN a regulator for the transcriptional activity of SRF?

Answer: Yes


Does quitting smoking reduce lung cancer risk by approximately 50%?

Answer: Yes


Do patients in stable partnerships have a slower progression from HIV to AIDS?

Answer: Yes


Do patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships?

Answer: No


Are patients with common epithelial cancers more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas?

Answer: Yes


Do patients with common epithelial cancers have a lower likelihood of having an emergency event as their first hospital admission if they live in resource-deprived areas?

Answer: No


Are patients with microcytosis and higher erythrocyte count more susceptible to severe malarial anaemia when infected with Plasmodium falciparum?

Answer: No


Are patients with microcytosis and higher erythrocyte count more resistant to severe malarial anaemia when infected with Plasmodium falciparum?

Answer: Yes


Do patients with panic anxiety show decreased levels of hypocretin in their CSF?

Answer: No


Does breathing 80 ppm iNO for 4 hours increase morphine use in pediatric SCD patients with vaso-occlusive crisis?

Answer: Yes


Is the perigenital skin the primary site of HIV acquisition?

Answer: Not Sure Enough


Is peroxynitrite required for induction of T cell tolerance?

Answer: Yes


Does persister cells provide relapse resistance in cancer patients?

Answer: Not Sure Enough


Is persistor cells one reason for incomplete responses to Tyrosine kinase inhibitor (TKI) therapy in cancer patients?

Answer: Not Sure Enough


Does pharmacist attendance at ward rounds increase adverse events in wards?

Answer: No


Does pharmacist attendance at ward rounds reduce adverse events in wards?

Answer: Yes


Is phase information helpful for predicting donor-recipient matches in organ transplantation?

Answer: Yes


Does physical activity improve cognitive function in individuals with Alzheimers?

Answer: No


Does physical activity level have an association with the difference in maximal oxygen consumption between black and white youth?

Answer: Not Sure Enough


Is physical activity level associated with the difference in maximal oxygen consumption between black and white youth?

Answer: Not Sure Enough


Does physical injury inhibit transglutaminase activity?

Answer: Not Sure Enough


Are Piezo1 channels sensors for cell migration in epithelial cells?

Answer: Yes


Is Pioglitazone use associated with an increased risk of prostate cancer?

Answer: No


Is the use of pioglitazone associated with an increased risk of pancreatic cancer?

Answer: Yes


Is the use of pioglitazone significantly associated with an increased risk of prostate cancer?

Answer: Yes


Does the pioneer factor OCT3/4 interact with major chromatin remodeling factors?

Answer: Yes


Does Polymeal nutrition increase cardiovascular mortality?

Answer: No


Does post-transcriptional handling of mitochondrial transcripts occur in mitochondrial RNA granules?

Answer: Yes


Is it true that pre-mRNAs associated with spliceosomal components are less stable than unassociated splicing substrates?

Answer: No


Are pre-mRNAs associated with spliceosomal components more stable than unassociated splicing substrates?

Answer: Yes


Does prescribed exercise training improve quality of life?

Answer: Yes


Does PrimPol degrade short DNA replication intermediates on the leading strand during DNA replication?

Answer: Not Sure Enough


Does PrimPol generate short DNA replication intermediates on the leading strand during DNA replication?

Answer: Not Sure Enough


Does primary cervical cancer screening with HPV detection have lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2?

Answer: No


Does primary cervical cytology screening with HPV detection have higher longitudinal sensitivity to detect severe cervical intraepithelial neoplasia than conventional cytology?

Answer: Yes


Do primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators?

Answer: Not Sure Enough


Are pro-inflammatory cytokines up regulated during tumor development?

Answer: Yes


Are pro-inflammatory cytokines repressed up during tumor development?

Answer: Not Sure Enough


Does Progerin induce premature aging in stem cells?

Answer: Yes


Are propriospinal interneurons integral for recovery from spinal cord injury because they play a role in the plastic reorganization of spinal circuits?

Answer: Yes


Does the pseudogene PTENP1 encode a transcript that regulates PTEN expression?

Answer: Yes


Is it true that pseudoknots are not evolutionarily conserved in most eukaryotes?

Answer: Not Sure Enough


Can pure neural progenitor cell populations be obtained without undergoing passaging, filtration, or other isolation and cell sorting methods?

Answer: Not Sure Enough


Does Pyridostatin decrease telomere fragility in BRCA2-deficient cells?

Answer: No


Does pyridostatin deregulate G2/M progression?

Answer: Yes


Does pyridostatin promote proliferation of homologous recombination-defective cells?

Answer: No


Does pyridostatin induce checkpoint activation?

Answer: Yes


Does Pyridostatin induce accumulation of double-strand breaks?

Answer: Yes


Does Pyridostatin prevent the accumulation of double-strand breaks?

Answer: No


Does Pyridostatin reduce the proliferation of homologous recombination-defective cells?

Answer: Yes


Does pyridostatin stabilize the G-quadruplex in the telomeric region?

Answer: Yes


Does R2D2 stop miRNA production by increasing the selectivity of Dcr2 for long dsRNA?

Answer: Not Sure Enough


Does the activation of RA induce hallmarks of transcriptionally active promoters in DIF2 and NB4 cells?

Answer: Not Sure Enough


Is RAD52 involved in break-induced DNA replication (BIR)?

Answer: Yes


Does the RANK-RANKL pathway signalling have any known association with the development of Aire-expressing medullary thymic epithelial cells?

Answer: No


Is the RANK-RANKL pathway signalling linked to the development of Aire-expressing medullary thymic epithelial cells?

Answer: Yes


Does RTEL1 interact with TRF2 through a C4C4 motif?

Answer: Yes


Answer: Not Sure Enough


Is RUNX1 downregulated or mutated in TLX1 T-ALL?

Answer: Yes


Does radioiodine treatment of non-toxic multinodular goitre increase thyroid volume?

Answer: No


Does rapamycin delay aging in fruit flies?

Answer: Yes


Does rapamycin increase the concentration of triacylglycerols in fruit flies?

Answer: Not Sure Enough


Is there a correlation between histidine kinase regulator specificity and rapid phosphotransfer rates?

Answer: Yes


Does recognition of start codons depend on the translation initiation factor IF3?

Answer: Yes


Does reduced levels of lipolysis lead to higher P38 phosphorylation in adipose tissue?

Answer: Not Sure Enough


Does reduced phosphorylation of PP2A increase HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction?

Answer: Not Sure Enough


Does reduced phosphorylation of PP2A suppress HDAC4 dephosphorylation?

Answer: Not Sure Enough


Is reduced responsiveness to interleukin-2 in regulatory T cells associated with autoimmune diseases such as Type 1 Diabetes?

Answer: Yes


Does reducing H3k4me3 methylation efficiently induce mouse epiblast stem cells to naive pluripotency?

Answer: Yes


Does reduction of Rpl38 alter the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis?

Answer: Yes


Does stronger spots for OmpA in 2D BN-PAGE gels indicate a reduction of purity of cytoplasmic membranes isolated from overexpressors?

Answer: Not Sure Enough


Is the reduction of purity of cytoplasmic membranes indicated by stronger spots for OmpF in 2D BN-PAGE gels?

Answer: Not Sure Enough


Does the removal of H3K9me3 by ectopic expression of other H3K9 demethylases decrease reprogramming efficiency in SCNT experiments?

Answer: No


Does ectopic expression of other H3K9 demethylases improve reprogramming efficiency in SCNT experiments by removing H3K9me3?

Answer: Yes


Does removal of H3K9me3 improve reprogramming efficiency in human somatic cell nuclear transfer experiments?

Answer: Yes


Does replacement of OCT4 and SOX2 genes with GATA3 have the ability to reprogram human cells?

Answer: Not Sure Enough


Is the replacement of OCT4 and SOX2 genes with GATA3 capable of reprogramming human cells?

Answer: Not Sure Enough


Does replacing histone H2A with H2A.Z accelerate gene activation in yeasts by destabilizing +1 nucleosomes?

Answer: Yes


Does repressing IL-18 have negative effects on atherosclerotic lesion composition and progression?

Answer: No


Is RORγ a therapeutic target for castration-resistant prostate cancer (CRPC)?

Answer: Yes


Does rhythmic expression of Cry1 lead to circadian regulation of cAMP signaling in gluconeogenesis?

Answer: Yes


Does rhythmic expression of Cry1 directly translate into a circadian regulation of cAMP signaling in hepatic glucose metabolism?

Answer: Yes


Is RP expression controlled in part by stress-activated regulators?

Answer: Not Sure Enough


Does Ribosome-inactivating protein-2 (RIP-2) interact with the p75 NTR death domain?

Answer: Not Sure Enough


Does ribosomopathies have a high degree of cell and tissue specific pathology?

Answer: Yes


Does risedronate increase the risk of both vertebral and non-vertebral fractures?

Answer: No


Does global warming increase the risk of dengue fever transmission due to rising temperatures?

Answer: Not Sure Enough


Does rising temperatures caused by global warming lower the risk of dengue fever transmission?

Answer: Not Sure Enough


Can the risk of cardiovascular events be reduced by a third among hemodialysis patients by using antihypertensive drug therapy?

Answer: Yes


Are risk-adjusted mortality rates similar in teaching and non-teaching hospitals?

Answer: Yes


Is it true that rotator cuff exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder?

Answer: Yes


Do roughly 55% of women with chronic pelvic pain have no underlying pathology?

Answer: Not Sure Enough


Is satellite cell dysfunction a key factor in sarcopenia development?

Answer: No


Does ScPif1p have a higher binding ability to G-rich ssDNA than to non-G-rich ssDNA?

Answer: Not Sure Enough


Does ScPif1p have reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA?

Answer: Not Sure Enough


Is it true that scapular stabilizer exercises are more effective than general exercise therapy in reducing pain and improving function of the shoulder?

Answer: Yes


Is self-advocacy training effective at decreasing homelessness?

Answer: Not Sure Enough


Has sepsis related mortality remained stable between 2009-2014?

Answer: Yes


Has sepsis related mortality risen from 2009 to 2014?

Answer: No


Is sequence conservation in gene regulatory regions between species a high-accuracy predictor of conserved functionality?

Answer: Not Sure Enough


Is sequence conservation in gene regulatory regions between species a good predictor of conserved functionality?

Answer: Not Sure Enough


Does the side effects of antidepressants represent a mortality risk to postmenopausal women?

Answer: No


Does taking antidepressants increase the risk of stroke due to potential side effects?

Answer: Yes


Does the use of antidepressants decrease the risk of myocardial infarction by causing side effects?

Answer: Not Sure Enough


Does sildenafil worsen erectile function in men who experience sexual dysfunction due to the use of SSRI antidepressants?

Answer: No


Does engagement of Smc5/6 halt the activation of Mms21 SUMO E3 ligase through ATP-dependent remolding?

Answer: No


Is Sn present on mature DCs during inflammation in vivo?

Answer: Not Sure Enough


Can specialized functional cell types be derived from human pluripotent stem cells?

Answer: Not Sure Enough


Is splenomegaly observed in knockin mouse lacking the SHP-2 MAPK pathway?

Answer: Yes


Is stacking more stable when a purine is present in the +5 position (C1698)?

Answer: Not Sure Enough


Does stiff substrate encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner?

Answer: No


Does the degradation of beta-catenin occur in an integrin-dependent manner that inhibits mesodermal differentiation on stiff substrates?

Answer: Yes


Do stroke patients with prior use of direct oral anticoagulants have a higher risk of in-hospital mortality than stroke patients with prior use of warfarin?

Answer: No


Is it true that students who perform poorly in the early years of medical school are at increased risk for professional misconduct later in their careers?

Answer: Yes


Is it true that students who perform poorly in the early years of medical school are less likely to commit professional misconduct later in their careers?

Answer: No


Is suboptimal nutrition a leading cause of premature death?

Answer: Yes


Can sudden death occur in patients with complex ventricular arrhythmias?

Answer: Not Sure Enough


Can sudden death occur in patients with orthostatic hypertension without cardiac conduction abnormalities?

Answer: Not Sure Enough


Do surfactin producing cells and exopolymer producing cells work together to create "Van Gogh" bundles with sliding abilities on specific media?

Answer: Yes


Is surgical treatment superior to non-surgical treatment in treating adults with displaced fractures of the proximal humerus?

Answer: Yes


Do sweet taste receptors on the tongue get deactivated by 1-10 mM glucose?

Answer: Not Sure Enough


Is sympathetic nerve activity elevated throughout normal pregnancy?

Answer: Yes


Is sympathetic nerve activity reduced throughout normal pregnancy?

Answer: No


Does systemic immunosuppressive (IS) therapy increase the likelihood of cancer mortality in patients with inflammatory eye disease (IED)?

Answer: Yes


Does systemic immunosuppressive (IS) therapy increase the chance of cancer mortality in patients with inflammatory eye disease (IED)?

Answer: No


Is systemic lupus erythematosus a risk factor for cardiovascular disease?

Answer: Yes


Are T cell receptor/CD3 microdomains necessary for inducing the immunologic synapse?

Answer: Yes


Answer: Yes


Is TNFAIP3 a tumor enhancer for glioblastoma?

Answer: Yes


Is TNFAIP3 a glioblastoma tumor suppressor?

Answer: No


Is TNFAIP3 a tumor enhancer in glioblastoma?

Answer: Yes


Do TRAP+ osteoclasts regulate the maintenance of mature osteoblasts?

Answer: Yes


Does taking 400mg of α-tocopheryl acetate prevent prostate cancer?

Answer: Yes


Does taking 400mg of α-tocopheryl acetate in combination with vitamin C reduce the risk of prostate cancer?

Answer: No


Is taking anti-depressants associated with a decrease in the Aβ level in the brain of experimental animals?

Answer: Yes


Did taxation of sugar-sweetened beverages reduce the incidence rate of type II diabetes in India?

Answer: Yes


Is it true that ten percent (10%) of kidney cancers in the UK are attributable to excess weight?

Answer: Yes


Does the C-type lectin receptor (CLEC-2) rearrange the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces?

Answer: Yes


Did the DESMOND program cause substantial weight loss in most participants?

Answer: No


Does the DESMOND program demonstrate a significant impact on biochemical outcomes?

Answer: Yes


Does the DESMOND program demonstrate significant impact on lifestyle outcomes?

Answer: Yes


Does the DESMOND program show any significant impact on weight loss?

Answer: Yes


Is the DEXI promoter region bound by multiple transcription factors in a murine haematopoietic progenitor cell line?

Answer: Not Sure Enough


Does the DdrB protein from Deinococcus radiodurans function as a pentamer?

Answer: Yes


Does the G34R/V mutation result in a hypomethylated phenotype at the H3K36 histone?

Answer: Not Sure Enough


Answer: Not Sure Enough


Is the H2A-H2B eviction defect compensated for by other histone chaperone(s)?

Answer: Not Sure Enough


Is the HSV-2 infection typically asymptomatic?

Answer: Not Sure Enough


Does the M2-phenotype in brown adipose tissue macrophages increase brown adipose tissue thermogenic activity?

Answer: Yes


Does the NF-κB essential modulator gene promote intestinal inflammation by inducing receptor-interacting protein (RIP) kinase 1 kinase activity-mediated epithelial cell death?

Answer: No


Does the NF-κB essential modulator gene prevent intestinal inflammation by inhibiting receptor-interacting protein (RIP) kinase 1 kinase activity-induced epithelial cell death?

Answer: Yes


Does the PDPN gene deactivate the C-type lectin receptor (CLEC-2)?

Answer: No


Does the PPR MDA5 have twenty N-terminal CARD domains?

Answer: Not Sure Enough


Is the PRDM1 gene a key determinant of primordial germ cells?

Answer: Yes


Does the PRDM1 gene have an important role in primordial germ cell specification when it is combined with the PRDM14 gene?

Answer: Yes


Does the PRR MDA5 have a C-terminal domain?

Answer: Not Sure Enough


Is the RANK-RANK-Ligand (RANKL) pathway involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs)?

Answer: Yes


Does the Snf1 complex regulate carbon and energy metabolism in baker's yeast (Saccharomyces cerevisiae)?

Answer: Yes


Does the TRaF1/C5 rs10818488 allele polymorphism regulate the neighboring C5 gene?

Answer: Not Sure Enough


Can the US health care system save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program?

Answer: No


Is the data collection process of the World Health Organization biased downward by unequal selection of larger outbreaks?

Answer: Not Sure Enough


Is it true that the ability of activator E2Fs in preventing cell death is limited to terminally differentiated cells?

Answer: Not Sure Enough


Does the amount of publicly available DNA data double every 10 months?

Answer: Not Sure Enough


Does the appearance of brown-like or beige cells primarily occur in visceral fat, not subcutaneous fat?

Answer: Not Sure Enough


Is the artifactual C-terminal helix swapping observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily?

Answer: Not Sure Enough


Does combining physical examinations with C-reactive protein values improve the accuracy of radiographically verified pneumonia predictions?

Answer: No


Does the composition of myosin-II isoform switch from the A isoform to the B isoform during hematopoietic differentiation?

Answer: Not Sure Enough


Is the cytokine receptor involved in the production of myeloperoxidase in the left atrium and regulate chemotaxis and formation of lymph nodes?

Answer: Not Sure Enough


Can the deamination of cytidine to uridine on the minus strand of viral DNA induce G-to-A mutations and inactivate the viral genome?

Answer: Yes


Does the density of cytokine receptor bearing cells affect the distance over which cytokines act?

Answer: Yes


Does the density of cytokine receptor bearing cells have an effect on the distance over which cytokines act?

Answer: No


Does the deregulated and prolonged activation of monocytes have deleterious effects in chronic infectious conditions?

Answer: Not Sure Enough


Does the deregulated and prolonged activation of monocytes improve inflammatory disease outcomes?

Answer: Not Sure Enough


Is the effect of Lipopolysaccharides on kidney barrier function dependent on inflammation levels?

Answer: Not Sure Enough


Is the first MBT repeat necessary for the interaction between Drosophila's Sfmbt or its mammalian ortholog L3MBTL2 and the spacer region of Drosophila's Pleiohomeotic or its human ortholog YY1?

Answer: Not Sure Enough


Is the gene daf-16 necessary for all traits relating to decreased insulin/insulin-like growth factor (Igf) signaling since it encodes forkhead Box O (FOXO)?

Answer: Not Sure Enough


Does the generation of reactive oxygen species by activated oncogenes contribute to the increased genomic instability of leukaemia cells?

Answer: Yes


Does the innate immune response struggle to remove small numbers of parasites?

Answer: No


Does the latent infection of myeloid cells with human cytomegalovirus induce a number of changes in gene expression?

Answer: Yes


Is the mean suicide rate in women higher after miscarriage than live birth?

Answer: Yes


Is the mean suicide rate in women lower after a miscarriage than after a live birth?

Answer: No


Is the microtubule-dependent delivery and secretion of matrix metalloproteases (MMPs) partially responsible for the disassembly of adhesion sites?

Answer: Yes


Does the minor G allele of FOXO3 downregulate pro-inflammatory cytokines?

Answer: Yes


Is the minor G allele of FOXO3 associated with milder symptoms of Crohn's Disease?

Answer: Yes


Does the minor G allele of FOXO3 up-regulate IL-10?

Answer: Yes


Is the morphology change from large white adipocytes to small brown adipocytes a sign of decreased energy expenditure potential in white adipose tissue?

Answer: Not Sure Enough


Is the morphology change from large white adipocytes to small brown adipocytes a sign of increased energy expenditure potential in white adipose tissue?

Answer: Not Sure Enough


Are the most prevalent adverse events to Semaglutide cardiovascular?

Answer: No


Are gastrointestinal adverse events the most prevalent with Semaglutide?

Answer: Yes


Does the myocardial cell lineage develop from cardiac progenitors of exclusively endodermal origin?

Answer: No


Does the number of unfertilized oocytes in mated hermaphrodites increase with age?

Answer: Not Sure Enough


Has the one-child policy created a hospitable environment for female infants?

Answer: No


Did the origin of the CRF01_1b2k protein occur between 1923 and 1956?

Answer: Not Sure Enough


Does the peak incidence of fractures occur during pubertal growth spurt in early adolescents?

Answer: Yes


Does the peak incidence of fractures occur in toddlers?

Answer: No


Is the predominant localization of Linc00173 in mononuclear macrophage nuclei?

Answer: Not Sure Enough


Does the proliferative capacity of neural progenitors differ across species?

Answer: Yes


Is the proliferative capacity of progenitors regulated cell-autonomously?

Answer: Yes


Is the proportion of people with visual difficulty higher in low-income countries than in high-income countries?

Answer: Not Sure Enough


Does the recruitment of Wdr5 to its target loci depend on Kat8?

Answer: Yes


Is the relationship between a breast cancer patient's capacity to metabolize tamoxifen and treatment outcome independent of the patient's genetic make-up?

Answer: No


Does the removal of reactive oxygen species by activated oncogenes contribute to the increased genomic instability of leukemia cells?

Answer: No


Does the repeat-variable diresidue (RVD) located in the loop of Transcription-Activator Like (TAL) effectors determine the nucleotides-amino acid contact at the target promoter element?

Answer: Yes


Does the risk of breast cancer among parous women decrease with placental weight of pregnancies?

Answer: No


Does the risk of cancer increase with level of alcohol consumption?

Answer: Yes


Is the risk of female prisoners harming themselves ten times higher than that of male prisoners?

Answer: Yes


Is the tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) decorated with VgrG and PAAR proteins?

Answer: Not Sure Enough


Does the tissue surrounding the granuloma in an immune cell induce an anti-inflammatory immune response?

Answer: Yes


Does Therapeutics receiving accelerated approval encounter a lower frequency of post-marketing safety events?

Answer: No


Is there a positive correlation between hip fractures and statin use?

Answer: No


Is there a relationship between Erythromycin use and hypertrophic pyloric stenosis?

Answer: Yes


Is there an association between HNF4A mutations and diabetes risks?

Answer: Not Sure Enough


Is there an increased risk of hypospadias with clomiphene?

Answer: No


Is there any known interaction between Pioneer factor OCT3/4 and major chromatin remodeling factors?

Answer: No


Answer: No


Was there an estimated 30 million cases of pneumonia in young children worldwide in 2010?

Answer: Yes


Can thiopurine active metabolites be catabolized through dephosphorylation of thioguanine nucleotides?

Answer: Not Sure Enough


Does Tirasemtiv have any effect on cardiac muscle?

Answer: Not Sure Enough


Answer: Not Sure Enough


Does Tirasemtiv target fast-twitch muscle?

Answer: Yes


Is Toll-like receptor (TLR) signaling involved in the pathogenesis of human MDS?

Answer: Not Sure Enough


Does tonic signaling from the scFv induce constitutive stimulation?

Answer: Not Sure Enough


Is the tonic signaling from the scFv amplified by MyD88/CD40?

Answer: Not Sure Enough


Does tonic signaling from the scFv prevent constitutive stimulation?

Answer: Not Sure Enough


Are traditional reviews biased in their interpretations?

Answer: Not Sure Enough


Do trans-acting factors, such as lncRNAs, influence mRNA translation?

Answer: Yes


Does Transcription factor EB induce transcription of pro-inflammatory cytokines in macrophages infected with Staphylococcus aureus?

Answer: Yes


Do transcription rates in S. cerevisiae range between 0.7 and 2 kb/min?

Answer: Not Sure Enough


Do transcription rates in S. cerevisiae range between 7 and 12 kb/min?

Answer: Not Sure Enough


Can transplanted human glial progenitor cells mature in their host animal?

Answer: Yes


Does treatment with a protein named FN impair regenerative abilities of aged muscles?

Answer: No


Does treatment with a protein named FN restore regenerative abilities of aged muscles?

Answer: Yes


Did treatment with the EC uptake inhibitor AM404 result in a dose-dependent decrease in the expression of immobility?

Answer: Not Sure Enough


Does the incidence of tuberculosis occur at higher rates in more sparsely populated areas in the UK?

Answer: No


Does tuberculosis-induced granulomas express different immune system protein signatures than the surrounding tissue?

Answer: Yes


Does tumor development occur in conjunction with the suppression of pro-inflammatory cytokines?

Answer: Not Sure Enough


Does tumor development occur in conjunction with upregulation of pro-inflammatory cytokines?

Answer: Not Sure Enough


Is it true that two variants of chromosome 6q21 are associated with radiation therapy-induced second malignancies in pediatric Hodgkin lymphoma patients?

Answer: Yes


Is Type 1 Diabetes associated with subtle perturbations in T reg development?

Answer: Yes


Does ultrasound guidance significantly reduce the number of needle insertion attempts necessary for a given procedure?

Answer: Yes


Does ultrasound guidance significantly reduce the number of traumatic procedures when attempting needle insertion?

Answer: Yes


Is understanding epigenetic regulation of replication essential for the rational design of episomally replicating vectors?

Answer: Not Sure Enough


Does up-regulation of the p53 pathway and related molecular events accelerate cancer progression?

Answer: Not Sure Enough


Does the emergence of new mutations in epidermal growth factor receptors lead to treatment failure when developing tyrosine-kinase inhibitor resistance?

Answer: Yes


Do influenza-specific memory CD4+ T cells reduce the early production of inflammatory chemokines in the lung upon viral challenge?

Answer: No


Do influenza-specific memory CD4+ T cells significantly increase the early production of inflammatory chemokines in the lung upon viral challenge?

Answer: Yes


Does upregulation of PD1 result in the downmodulation of Satb1?

Answer: Not Sure Enough


Does the upregulation of PD1 cause the upregulation of Satb1?

Answer: Not Sure Enough


Does upregulating dynein in Drosophila neurons increase the number of microtubule plus-ends growing toward the cell body of each neuron?

Answer: No


Is urbanization an important risk factor related to the transmission of dengue fever?

Answer: Not Sure Enough


Does V-9302 decrease cell death and oxidative stress, thus inhibiting antitumor responses?

Answer: No


Does vaccinating the gastrointestinal tract induce protection of rectal and vaginal mucosa?

Answer: Yes


Is varenicline monotherapy more effective than combination nicotine replacement therapies with varenicline or bupropion after 26 weeks of treatment?

Answer: No


Do varying expression levels of EBI2 affect the positioning and migration of B cells?

Answer: Yes


Does venules have less significant tunica adventitia than arterioles?

Answer: Not Sure Enough


Does the VgrG (Tssl) protein puncture membranes by forming a spike at the tip of the tube apparatus?

Answer: Yes


Does vitamin D deficiency affect birth weight?

Answer: Yes


Is vitamin D an important factor in the relationship between calcium and parathyroid hormone?

Answer: Yes


Did walking in traffic areas in London improve lung function in elderly adults?

Answer: Yes


Does walking in traffic areas in London improve lung function in elderly adults?

Answer: No


Do weighed food records (WFR) result in high completion due to their low cost to run and minimal participant burden?

Answer: Not Sure Enough


Do weighed food records result in poor completion due to the high participant burden and cost?

Answer: Not Sure Enough


Does whole brain radiotherapy increase the occurrence of new brain metastases?

Answer: No


Are women more susceptible to death due to pneumonia than men?

Answer: Yes


Is it true that women with a lower birth weight are more likely to develop breast cancer later in life?

Answer: No


Is YAP/TAZ required for intestinal regeneration in mouse models of ulcerative colitis?

Answer: Yes


Does aPKCz affect glutamine metabolism to cause tumour suppression?

Answer: Yes


Does cSMAC formation repress weak ligand signalling?

Answer: No


Is it true that eRNAs are linked to senescence, aging, and carcinogenesis?

Answer: Not Sure Enough


Is mcm 5 s 2 U required for proper decoding of NNR codons in eukaryotes?

Answer: Yes


Is miR-142-5P a known regulator of raised body temperature?

Answer: Yes


Is miR-142-5P a temperature-sensitive microRNA (miRNA)?

Answer: Yes


Do miRNAs suppress low-level "leaky" transcription to enforce homeostasis?

Answer: Yes


Do miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells?

Answer: Not Sure Enough


Is p16INK4A degradation linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs)?

Answer: Not Sure Enough


Is p16INK4A degradation encoded by CDKN2A?

Answer: Not Sure Enough


Does NADE interact with the death domain of p75 NTR?

Answer: Not Sure Enough


Is there an association between qSOFA scores and length of stay in emergency department patients?

Answer: Not Sure Enough


Are r-protein chaperones found in complexes with their r-protein binding partners?

Answer: Not Sure Enough


Does siRNA knockdown of A20 accelerate tumor progression in an in vivo murine xenograft model?

Answer: No


Does siRNA knockdown of A20 slow tumor progression in an in vivo murine xenograft model?

Answer: Yes


Do taa1 tar1 tar2 triple mutants in Arabidopsis make root meristem during embryogenesis?

Answer: Not Sure Enough


Does β-sheet opening occur during pleurotolysin pore formation?

Answer: Yes


Answer: Not Sure Enough


Do 10-20% of people with severe mental disorder receive no treatment in low and middle income countries?

Answer: No


Will 25% of patients with melanoma who respond to PD-1 blockade experience a progression in their melanoma?

Answer: Not Sure Enough


Do 50% of patients exposed to radiation show activated markers of myofibroblasts?

Answer: Not Sure Enough


Are 8% of burn patients admitted for hospitalization and further treatment after appearing at hospital emergency wards or outpatient clinics?

Answer: Not Sure Enough


Does a breast cancer patient's capacity to metabolize tamoxifen have any effect on treatment outcome?

Answer: No


Is the eligibility of a country for the Vaccine Alliance (GAVI) associated with accelerated adoption of the Hub vaccine?

Answer: Yes


Does a deficiency of folate decrease blood levels of homocysteine?

Answer: No


Does a deficiency of vitamin B6 increase blood levels of homocysteine?

Answer: Yes


Does the expression of APOE4 in iPSC-derived neurons result in increased tau phosphorylation?

Answer: Yes


Does AZT given with ribavirin alleviate anemia?

Answer: Not Sure Enough


Do adipocytes in major adipose depots come from cells that have a history of Pdgfra expression?

Answer: Yes


Are adult tissue-resident macrophages maintained independent of circulating monocytes?

Answer: Yes


Do adult tissue-resident macrophages possess a self-renewing capacity?

Answer: Yes


Does Alirocumab treatment increase the apo(a) fractional clearance rate?

Answer: Yes


Do all phenotypes associated with reduced IIS require the gene daf-16?

Answer: Yes


Are all six cathelicidins located on chromosome two?

Answer: Not Sure Enough


Are the allele and genotype frequencies of the rs4516035 and rs2298850 SNPs associated with region in Mexico in Mexican populations?

Answer: Not Sure Enough


Is Amitriptyline ineffective as a treatment for chronic tension-type headaches?

Answer: No


Does an N-formyl group on M3 molecules suppress strong binding to the second position of the groove?

Answer: Not Sure Enough


Does antibiotic-induced alterations in the gut microbiome increase resistance against Clostridium difficile?

Answer: No


Are approximately 22,500 people infected with human T-cell lymphotropic virus type 1 in the United Kingdom?

Answer: Not Sure Enough


Does aspirin encourage the production of PGE2?

Answer: No


Does asymptomatic bacteriuria have any effect on the risk for preterm delivery and low birth weight?

Answer: No


Does asymptomatic bacteriuria increase the risk for preterm delivery and low birth weight?

Answer: Not Sure Enough


Does autologous transplantation of mesenchymal stem cells have worse graft function compared to induction therapy with anti-interleukin-2 receptor antibodies?

Answer: No


Does autophagy deficiency in the liver protect from insulin resistance?

Answer: Yes


Does bariatric surgery reduce resolution of diabetes?

Answer: No


Do bnAb 10EB exhibit a strong affinity for phospholipids?

Answer: No


Does Bromodomain proteins promote the differentiation process of bloodstream form (BSF) to procyclic form (PCF) parasites?

Answer: No


Is bronchial responsiveness higher in the summer than in the winter?

Answer: No


Is bronchial responsiveness the same in the winter and summer seasons?

Answer: Yes


Is C-Met involved in epithelial-mesenchymal transition in tumor cells?

Answer: Yes


Does the activation of nuclear RNAi cause C. elegans germlines to lose their immortal character?

Answer: No


Does disabling nuclear RNAi cause C. elegans germlines to lose their immortal character?

Answer: Yes


Does CENP-B inhibit heterochromatin formation?

Answer: No


Do CRY proteins mediate light signal transduction?

Answer: Yes


Do carriers of the alcohol aldehyde dehydrogenase deficiency mutation drink more than non-carriers?

Answer: No


Does cell autonomous sex determination occur in Passeriformes?

Answer: No


Is cellular aging correlated with an older appearance?

Answer: No


Is the choice of specialty influenced by debt accrued from medical training?

Answer: Yes


Does chronic aerobic exercise alter endothelial function, impairing vasodilating mechanisms mediated by NO?

Answer: No


Answer: Yes


Does colloid exposure have any effect on morbidity?

Answer: No


Is there a significant difference in long-term abstinence rates at 52 weeks between combination nicotine replacement therapies with varenicline or bupropion and varenicline monotherapy?

Answer: Yes


Is combining phosphatidylinositide 3-kinase and MEK 1/2 inhibitors effective at treating KRAS mutant tumors?

Answer: No


Do conformational changes of the CD3 complex enable ITAM phosphorylation?

Answer: Not Sure Enough


Does consumption of whole fruits reduce the risk of type 2 diabetes?

Answer: Yes


Does coordinated stabilization of kinetochore-microtubule attachments occur at the prometaphase to metaphase transition?

Answer: Yes


Are correlative electron microscopy and superresolution fluorescence imaging imaging techniques?

Answer: Yes


Does cost effectiveness evaluations based on cRCT data represent patients in actual clinical practice?

Answer: Yes


Is Cyclin A2 synthesis necessary to switch from unstable to stable kt-mt attachments in mitosis?

Answer: No


Do cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1?

Answer: Not Sure Enough


Does downregulation of DUSP4 activate the Ras-ERK pathway?

Answer: Yes


Does de novo assembly of sequence data have longer contigs than unassembled sequence data?

Answer: Not Sure Enough