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“An 18-year-old male presented with a short history of 8 days of weakness of both lower limbs. There was no history of trauma or tuberculosis or skin lesions in form of papules or macules. No other complaint was associated and the past history was of no significance. The cranial neurological examination was normal. His... | The second child (Fig. ) of a 29-year-old woman was spontaneously born at 39 + 4 weeks of gestation after an unremarkable pregnancy. Birth weight was 3510 g (50th percentile), length 55 cm (75th percentile) and head circumference 33.5 cm (20th percentile). Apgar scores were 9/10/10. At the age of 3 months the girl was ... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
A 50-year-old male patient was referred to our hospital, with a 4-month history of neck pain and gradually progressive weakness of all four limbs. Over the past 2 weeks, the patient noticed significant deterioration and became bed bound. The patient denies any previous history of trauma, malignancy, or medical history ... | “An 18-year-old male presented with a short history of 8 days of weakness of both lower limbs. There was no history of trauma or tuberculosis or skin lesions in form of papules or macules. No other complaint was associated and the past history was of no significance. The cranial neurological examination was normal. His... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
The mother of a 1-year-old girl initially noticed reduced activity of the lower limbs which worsened over 8 days. On examination paraplegia, exaggerated deep tendon reflexes and positive Babinski sign were noted. No other neurological deficit found. Cutaneous lesions were absent. Magnetic resonance imaging (MRI) of the... | “An 18-year-old male presented with a short history of 8 days of weakness of both lower limbs. There was no history of trauma or tuberculosis or skin lesions in form of papules or macules. No other complaint was associated and the past history was of no significance. The cranial neurological examination was normal. His... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
“An 18-year-old male presented with a short history of 8 days of weakness of both lower limbs. There was no history of trauma or tuberculosis or skin lesions in form of papules or macules. No other complaint was associated and the past history was of no significance. The cranial neurological examination was normal. His... | A 15-year-old male presented with pain in the nape of the neck and gradually progressive ascending weakness of all four limbs along with bladder and bowel involvement for 3 years. On examination, tone was increased in all four limbs with 4/5 power in bilateral upper limbs and 2/5 power in both lower limbs, along with e... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
A 29-year-old male patient presented with right side weakness and left side numbness that occurred just after a car accident. Upon physical examination, there was no abnormal finding, except for tenderness in the upper cervical area. Routine laboratory tests demonstrated normal results. Motor weakness of right side ext... | “An 18-year-old male presented with a short history of 8 days of weakness of both lower limbs. There was no history of trauma or tuberculosis or skin lesions in form of papules or macules. No other complaint was associated and the past history was of no significance. The cranial neurological examination was normal. His... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
A 50-year-old male patient was referred to our hospital, with a 4-month history of neck pain and gradually progressive weakness of all four limbs. Over the past 2 weeks, the patient noticed significant deterioration and became bed bound. The patient denies any previous history of trauma, malignancy, or medical history ... | The second child (Fig. ) of a 29-year-old woman was spontaneously born at 39 + 4 weeks of gestation after an unremarkable pregnancy. Birth weight was 3510 g (50th percentile), length 55 cm (75th percentile) and head circumference 33.5 cm (20th percentile). Apgar scores were 9/10/10. At the age of 3 months the girl was ... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
The second child (Fig. ) of a 29-year-old woman was spontaneously born at 39 + 4 weeks of gestation after an unremarkable pregnancy. Birth weight was 3510 g (50th percentile), length 55 cm (75th percentile) and head circumference 33.5 cm (20th percentile). Apgar scores were 9/10/10. At the age of 3 months the girl was ... | The mother of a 1-year-old girl initially noticed reduced activity of the lower limbs which worsened over 8 days. On examination paraplegia, exaggerated deep tendon reflexes and positive Babinski sign were noted. No other neurological deficit found. Cutaneous lesions were absent. Magnetic resonance imaging (MRI) of the... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
The second child (Fig. ) of a 29-year-old woman was spontaneously born at 39 + 4 weeks of gestation after an unremarkable pregnancy. Birth weight was 3510 g (50th percentile), length 55 cm (75th percentile) and head circumference 33.5 cm (20th percentile). Apgar scores were 9/10/10. At the age of 3 months the girl was ... | A 15-year-old male presented with pain in the nape of the neck and gradually progressive ascending weakness of all four limbs along with bladder and bowel involvement for 3 years. On examination, tone was increased in all four limbs with 4/5 power in bilateral upper limbs and 2/5 power in both lower limbs, along with e... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
A 29-year-old male patient presented with right side weakness and left side numbness that occurred just after a car accident. Upon physical examination, there was no abnormal finding, except for tenderness in the upper cervical area. Routine laboratory tests demonstrated normal results. Motor weakness of right side ext... | The second child (Fig. ) of a 29-year-old woman was spontaneously born at 39 + 4 weeks of gestation after an unremarkable pregnancy. Birth weight was 3510 g (50th percentile), length 55 cm (75th percentile) and head circumference 33.5 cm (20th percentile). Apgar scores were 9/10/10. At the age of 3 months the girl was ... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
A 50-year-old male patient was referred to our hospital, with a 4-month history of neck pain and gradually progressive weakness of all four limbs. Over the past 2 weeks, the patient noticed significant deterioration and became bed bound. The patient denies any previous history of trauma, malignancy, or medical history ... | The mother of a 1-year-old girl initially noticed reduced activity of the lower limbs which worsened over 8 days. On examination paraplegia, exaggerated deep tendon reflexes and positive Babinski sign were noted. No other neurological deficit found. Cutaneous lesions were absent. Magnetic resonance imaging (MRI) of the... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
A 50-year-old male patient was referred to our hospital, with a 4-month history of neck pain and gradually progressive weakness of all four limbs. Over the past 2 weeks, the patient noticed significant deterioration and became bed bound. The patient denies any previous history of trauma, malignancy, or medical history ... | A 15-year-old male presented with pain in the nape of the neck and gradually progressive ascending weakness of all four limbs along with bladder and bowel involvement for 3 years. On examination, tone was increased in all four limbs with 4/5 power in bilateral upper limbs and 2/5 power in both lower limbs, along with e... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
A 50-year-old male patient was referred to our hospital, with a 4-month history of neck pain and gradually progressive weakness of all four limbs. Over the past 2 weeks, the patient noticed significant deterioration and became bed bound. The patient denies any previous history of trauma, malignancy, or medical history ... | A 29-year-old male patient presented with right side weakness and left side numbness that occurred just after a car accident. Upon physical examination, there was no abnormal finding, except for tenderness in the upper cervical area. Routine laboratory tests demonstrated normal results. Motor weakness of right side ext... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
A 15-year-old male presented with pain in the nape of the neck and gradually progressive ascending weakness of all four limbs along with bladder and bowel involvement for 3 years. On examination, tone was increased in all four limbs with 4/5 power in bilateral upper limbs and 2/5 power in both lower limbs, along with e... | The mother of a 1-year-old girl initially noticed reduced activity of the lower limbs which worsened over 8 days. On examination paraplegia, exaggerated deep tendon reflexes and positive Babinski sign were noted. No other neurological deficit found. Cutaneous lesions were absent. Magnetic resonance imaging (MRI) of the... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
A 29-year-old male patient presented with right side weakness and left side numbness that occurred just after a car accident. Upon physical examination, there was no abnormal finding, except for tenderness in the upper cervical area. Routine laboratory tests demonstrated normal results. Motor weakness of right side ext... | The mother of a 1-year-old girl initially noticed reduced activity of the lower limbs which worsened over 8 days. On examination paraplegia, exaggerated deep tendon reflexes and positive Babinski sign were noted. No other neurological deficit found. Cutaneous lesions were absent. Magnetic resonance imaging (MRI) of the... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
A 29-year-old male patient presented with right side weakness and left side numbness that occurred just after a car accident. Upon physical examination, there was no abnormal finding, except for tenderness in the upper cervical area. Routine laboratory tests demonstrated normal results. Motor weakness of right side ext... | A 15-year-old male presented with pain in the nape of the neck and gradually progressive ascending weakness of all four limbs along with bladder and bowel involvement for 3 years. On examination, tone was increased in all four limbs with 4/5 power in bilateral upper limbs and 2/5 power in both lower limbs, along with e... | 0 | Write a detailed clinical case vignette based on the following key phrases: Histiocytic lesions, Spinal cord compression, Xanthoma/xanthogranuloma |
A 58-year-old man presented to us three years ago with a history of progressive anterior neck swelling and hoarseness of voice for the past one month. On clinical examination, there was palpable left anterior neck swelling with cervical lymphadenopathy. A core needle biopsy of the lesion revealed invasive poorly differ... | Patient 3 was a 67-year-old female who presented with hoarseness and dysphagia for a few weeks. CT scans showed a 3.8 cm left thyroid tumor with superior mediastinal and tracheal involvements, i.e., stage pT4bN0M0. Complete resection of the tumor was successfully achieved by total thyroidectomy and central neck dissect... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 58-year-old man presented to us three years ago with a history of progressive anterior neck swelling and hoarseness of voice for the past one month. On clinical examination, there was palpable left anterior neck swelling with cervical lymphadenopathy. A core needle biopsy of the lesion revealed invasive poorly differ... | Patient 1 was a 61-year-old female who presented with a 5-cm anterior neck mass with retrosternal extension. She was surgically treated with a right thyroid lobectomy at another institution. The lesion was interpreted to be a poorly differentiated papillary thyroid cancer. Postoperative treatment consisted of sequentia... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 58-year-old man presented to us three years ago with a history of progressive anterior neck swelling and hoarseness of voice for the past one month. On clinical examination, there was palpable left anterior neck swelling with cervical lymphadenopathy. A core needle biopsy of the lesion revealed invasive poorly differ... | A 60-year-old gentleman with past medical history of cervical disk herniation presented with a 3-year history of progressive fatigue and bilateral upper extremity weakness. MRI was performed to evaluate the spine and was consistent with cervical spinal stenosis. T2 non-contrast images incidentally revealed an infiltrat... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 58-year-old man presented to us three years ago with a history of progressive anterior neck swelling and hoarseness of voice for the past one month. On clinical examination, there was palpable left anterior neck swelling with cervical lymphadenopathy. A core needle biopsy of the lesion revealed invasive poorly differ... | Patient 2 was a 48-year-old male pathologically diagnosed with stage pT4aN0M0 CASTLE postsurgery. He presented with rapidly growing thyroid nodules with fixation to underlying structures. He underwent total thyroidectomy with central neck dissection. On exploration, the thyroid mass was seen extended to the left laryng... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 58-year-old man presented to us three years ago with a history of progressive anterior neck swelling and hoarseness of voice for the past one month. On clinical examination, there was palpable left anterior neck swelling with cervical lymphadenopathy. A core needle biopsy of the lesion revealed invasive poorly differ... | A 34-year-old woman presented with a 2-month history of sore throat. The patient had no notable medical or family history. Physical examination revealed a palpable right thyroid mass. Thyroid function and calcium tests were within normal limits. Ultrasound showed a 1.7-cm, well demarcated, heterogeneous, low echoic sol... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 58-year-old man presented to us three years ago with a history of progressive anterior neck swelling and hoarseness of voice for the past one month. On clinical examination, there was palpable left anterior neck swelling with cervical lymphadenopathy. A core needle biopsy of the lesion revealed invasive poorly differ... | A 79-year old woman was hospitalized on April 25, 2018, at which time she had progressive dyspnea over the past 5 weeks, productive cough, poor appetite, and weight loss of 5 kg over the last 6 months currently weighing 81 kg. Her medical history included an invasive ductal breast cancer pT1cN0M0 G2 ER 90%, PR 20% 20 y... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 58-year-old man presented to us three years ago with a history of progressive anterior neck swelling and hoarseness of voice for the past one month. On clinical examination, there was palpable left anterior neck swelling with cervical lymphadenopathy. A core needle biopsy of the lesion revealed invasive poorly differ... | A 52-year-old woman was referred to our hospital because of severe dyspnea and the presence of a neck tumor. She had experienced dyspnea for the past 6 months and had recently noticed bloody sputum. A computed tomography examination of the neck revealed a thyroid tumor about 8 cm in size. The tumor had invaded the trac... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 58-year-old man presented to us three years ago with a history of progressive anterior neck swelling and hoarseness of voice for the past one month. On clinical examination, there was palpable left anterior neck swelling with cervical lymphadenopathy. A core needle biopsy of the lesion revealed invasive poorly differ... | A 76-year-old man was referred to our hospital for investigation of a 20-day history of rapidly deteriorating dyspnea and severe cough. This was associated with dysphagia and cervical pain. The patient was an ex-marble craftsman and an active smoker. His medical history included chronic pulmonary obstructive disease (C... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 58-year-old man presented to us three years ago with a history of progressive anterior neck swelling and hoarseness of voice for the past one month. On clinical examination, there was palpable left anterior neck swelling with cervical lymphadenopathy. A core needle biopsy of the lesion revealed invasive poorly differ... | The patient, a 28-year-old man with a 3-month-old mass in the neck was referred to our department. The mass, located on the left thyroid lobe, was elastic, hard, showed limited mobility, and measured approximately 30 × 20 mm. There was no remarkable tenderness over the mass.\nBlood examination results were normal, incl... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 58-year-old man presented to us three years ago with a history of progressive anterior neck swelling and hoarseness of voice for the past one month. On clinical examination, there was palpable left anterior neck swelling with cervical lymphadenopathy. A core needle biopsy of the lesion revealed invasive poorly differ... | A 60-year-old woman, who was diagnosed with cancer of the thyroid gland in 2015, was treated with total thyroidectomy and lymph node dissection. Her postoperative pathology showed carcinoma showing thymus-like differentiation (CASTLE). She was discharged on Levothyroxine 100 mg/day. She did not attend her follow-up app... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
Patient 3 was a 67-year-old female who presented with hoarseness and dysphagia for a few weeks. CT scans showed a 3.8 cm left thyroid tumor with superior mediastinal and tracheal involvements, i.e., stage pT4bN0M0. Complete resection of the tumor was successfully achieved by total thyroidectomy and central neck dissect... | Patient 1 was a 61-year-old female who presented with a 5-cm anterior neck mass with retrosternal extension. She was surgically treated with a right thyroid lobectomy at another institution. The lesion was interpreted to be a poorly differentiated papillary thyroid cancer. Postoperative treatment consisted of sequentia... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 60-year-old gentleman with past medical history of cervical disk herniation presented with a 3-year history of progressive fatigue and bilateral upper extremity weakness. MRI was performed to evaluate the spine and was consistent with cervical spinal stenosis. T2 non-contrast images incidentally revealed an infiltrat... | Patient 3 was a 67-year-old female who presented with hoarseness and dysphagia for a few weeks. CT scans showed a 3.8 cm left thyroid tumor with superior mediastinal and tracheal involvements, i.e., stage pT4bN0M0. Complete resection of the tumor was successfully achieved by total thyroidectomy and central neck dissect... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
Patient 3 was a 67-year-old female who presented with hoarseness and dysphagia for a few weeks. CT scans showed a 3.8 cm left thyroid tumor with superior mediastinal and tracheal involvements, i.e., stage pT4bN0M0. Complete resection of the tumor was successfully achieved by total thyroidectomy and central neck dissect... | Patient 2 was a 48-year-old male pathologically diagnosed with stage pT4aN0M0 CASTLE postsurgery. He presented with rapidly growing thyroid nodules with fixation to underlying structures. He underwent total thyroidectomy with central neck dissection. On exploration, the thyroid mass was seen extended to the left laryng... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 34-year-old woman presented with a 2-month history of sore throat. The patient had no notable medical or family history. Physical examination revealed a palpable right thyroid mass. Thyroid function and calcium tests were within normal limits. Ultrasound showed a 1.7-cm, well demarcated, heterogeneous, low echoic sol... | Patient 3 was a 67-year-old female who presented with hoarseness and dysphagia for a few weeks. CT scans showed a 3.8 cm left thyroid tumor with superior mediastinal and tracheal involvements, i.e., stage pT4bN0M0. Complete resection of the tumor was successfully achieved by total thyroidectomy and central neck dissect... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 79-year old woman was hospitalized on April 25, 2018, at which time she had progressive dyspnea over the past 5 weeks, productive cough, poor appetite, and weight loss of 5 kg over the last 6 months currently weighing 81 kg. Her medical history included an invasive ductal breast cancer pT1cN0M0 G2 ER 90%, PR 20% 20 y... | Patient 3 was a 67-year-old female who presented with hoarseness and dysphagia for a few weeks. CT scans showed a 3.8 cm left thyroid tumor with superior mediastinal and tracheal involvements, i.e., stage pT4bN0M0. Complete resection of the tumor was successfully achieved by total thyroidectomy and central neck dissect... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 52-year-old woman was referred to our hospital because of severe dyspnea and the presence of a neck tumor. She had experienced dyspnea for the past 6 months and had recently noticed bloody sputum. A computed tomography examination of the neck revealed a thyroid tumor about 8 cm in size. The tumor had invaded the trac... | Patient 3 was a 67-year-old female who presented with hoarseness and dysphagia for a few weeks. CT scans showed a 3.8 cm left thyroid tumor with superior mediastinal and tracheal involvements, i.e., stage pT4bN0M0. Complete resection of the tumor was successfully achieved by total thyroidectomy and central neck dissect... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 76-year-old man was referred to our hospital for investigation of a 20-day history of rapidly deteriorating dyspnea and severe cough. This was associated with dysphagia and cervical pain. The patient was an ex-marble craftsman and an active smoker. His medical history included chronic pulmonary obstructive disease (C... | Patient 3 was a 67-year-old female who presented with hoarseness and dysphagia for a few weeks. CT scans showed a 3.8 cm left thyroid tumor with superior mediastinal and tracheal involvements, i.e., stage pT4bN0M0. Complete resection of the tumor was successfully achieved by total thyroidectomy and central neck dissect... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
The patient, a 28-year-old man with a 3-month-old mass in the neck was referred to our department. The mass, located on the left thyroid lobe, was elastic, hard, showed limited mobility, and measured approximately 30 × 20 mm. There was no remarkable tenderness over the mass.\nBlood examination results were normal, incl... | Patient 3 was a 67-year-old female who presented with hoarseness and dysphagia for a few weeks. CT scans showed a 3.8 cm left thyroid tumor with superior mediastinal and tracheal involvements, i.e., stage pT4bN0M0. Complete resection of the tumor was successfully achieved by total thyroidectomy and central neck dissect... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 60-year-old woman, who was diagnosed with cancer of the thyroid gland in 2015, was treated with total thyroidectomy and lymph node dissection. Her postoperative pathology showed carcinoma showing thymus-like differentiation (CASTLE). She was discharged on Levothyroxine 100 mg/day. She did not attend her follow-up app... | Patient 3 was a 67-year-old female who presented with hoarseness and dysphagia for a few weeks. CT scans showed a 3.8 cm left thyroid tumor with superior mediastinal and tracheal involvements, i.e., stage pT4bN0M0. Complete resection of the tumor was successfully achieved by total thyroidectomy and central neck dissect... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 60-year-old gentleman with past medical history of cervical disk herniation presented with a 3-year history of progressive fatigue and bilateral upper extremity weakness. MRI was performed to evaluate the spine and was consistent with cervical spinal stenosis. T2 non-contrast images incidentally revealed an infiltrat... | Patient 1 was a 61-year-old female who presented with a 5-cm anterior neck mass with retrosternal extension. She was surgically treated with a right thyroid lobectomy at another institution. The lesion was interpreted to be a poorly differentiated papillary thyroid cancer. Postoperative treatment consisted of sequentia... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
Patient 2 was a 48-year-old male pathologically diagnosed with stage pT4aN0M0 CASTLE postsurgery. He presented with rapidly growing thyroid nodules with fixation to underlying structures. He underwent total thyroidectomy with central neck dissection. On exploration, the thyroid mass was seen extended to the left laryng... | Patient 1 was a 61-year-old female who presented with a 5-cm anterior neck mass with retrosternal extension. She was surgically treated with a right thyroid lobectomy at another institution. The lesion was interpreted to be a poorly differentiated papillary thyroid cancer. Postoperative treatment consisted of sequentia... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 34-year-old woman presented with a 2-month history of sore throat. The patient had no notable medical or family history. Physical examination revealed a palpable right thyroid mass. Thyroid function and calcium tests were within normal limits. Ultrasound showed a 1.7-cm, well demarcated, heterogeneous, low echoic sol... | Patient 1 was a 61-year-old female who presented with a 5-cm anterior neck mass with retrosternal extension. She was surgically treated with a right thyroid lobectomy at another institution. The lesion was interpreted to be a poorly differentiated papillary thyroid cancer. Postoperative treatment consisted of sequentia... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 79-year old woman was hospitalized on April 25, 2018, at which time she had progressive dyspnea over the past 5 weeks, productive cough, poor appetite, and weight loss of 5 kg over the last 6 months currently weighing 81 kg. Her medical history included an invasive ductal breast cancer pT1cN0M0 G2 ER 90%, PR 20% 20 y... | Patient 1 was a 61-year-old female who presented with a 5-cm anterior neck mass with retrosternal extension. She was surgically treated with a right thyroid lobectomy at another institution. The lesion was interpreted to be a poorly differentiated papillary thyroid cancer. Postoperative treatment consisted of sequentia... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 52-year-old woman was referred to our hospital because of severe dyspnea and the presence of a neck tumor. She had experienced dyspnea for the past 6 months and had recently noticed bloody sputum. A computed tomography examination of the neck revealed a thyroid tumor about 8 cm in size. The tumor had invaded the trac... | Patient 1 was a 61-year-old female who presented with a 5-cm anterior neck mass with retrosternal extension. She was surgically treated with a right thyroid lobectomy at another institution. The lesion was interpreted to be a poorly differentiated papillary thyroid cancer. Postoperative treatment consisted of sequentia... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 76-year-old man was referred to our hospital for investigation of a 20-day history of rapidly deteriorating dyspnea and severe cough. This was associated with dysphagia and cervical pain. The patient was an ex-marble craftsman and an active smoker. His medical history included chronic pulmonary obstructive disease (C... | Patient 1 was a 61-year-old female who presented with a 5-cm anterior neck mass with retrosternal extension. She was surgically treated with a right thyroid lobectomy at another institution. The lesion was interpreted to be a poorly differentiated papillary thyroid cancer. Postoperative treatment consisted of sequentia... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
The patient, a 28-year-old man with a 3-month-old mass in the neck was referred to our department. The mass, located on the left thyroid lobe, was elastic, hard, showed limited mobility, and measured approximately 30 × 20 mm. There was no remarkable tenderness over the mass.\nBlood examination results were normal, incl... | Patient 1 was a 61-year-old female who presented with a 5-cm anterior neck mass with retrosternal extension. She was surgically treated with a right thyroid lobectomy at another institution. The lesion was interpreted to be a poorly differentiated papillary thyroid cancer. Postoperative treatment consisted of sequentia... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 60-year-old woman, who was diagnosed with cancer of the thyroid gland in 2015, was treated with total thyroidectomy and lymph node dissection. Her postoperative pathology showed carcinoma showing thymus-like differentiation (CASTLE). She was discharged on Levothyroxine 100 mg/day. She did not attend her follow-up app... | Patient 1 was a 61-year-old female who presented with a 5-cm anterior neck mass with retrosternal extension. She was surgically treated with a right thyroid lobectomy at another institution. The lesion was interpreted to be a poorly differentiated papillary thyroid cancer. Postoperative treatment consisted of sequentia... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 60-year-old gentleman with past medical history of cervical disk herniation presented with a 3-year history of progressive fatigue and bilateral upper extremity weakness. MRI was performed to evaluate the spine and was consistent with cervical spinal stenosis. T2 non-contrast images incidentally revealed an infiltrat... | Patient 2 was a 48-year-old male pathologically diagnosed with stage pT4aN0M0 CASTLE postsurgery. He presented with rapidly growing thyroid nodules with fixation to underlying structures. He underwent total thyroidectomy with central neck dissection. On exploration, the thyroid mass was seen extended to the left laryng... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 60-year-old gentleman with past medical history of cervical disk herniation presented with a 3-year history of progressive fatigue and bilateral upper extremity weakness. MRI was performed to evaluate the spine and was consistent with cervical spinal stenosis. T2 non-contrast images incidentally revealed an infiltrat... | A 34-year-old woman presented with a 2-month history of sore throat. The patient had no notable medical or family history. Physical examination revealed a palpable right thyroid mass. Thyroid function and calcium tests were within normal limits. Ultrasound showed a 1.7-cm, well demarcated, heterogeneous, low echoic sol... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 60-year-old gentleman with past medical history of cervical disk herniation presented with a 3-year history of progressive fatigue and bilateral upper extremity weakness. MRI was performed to evaluate the spine and was consistent with cervical spinal stenosis. T2 non-contrast images incidentally revealed an infiltrat... | A 79-year old woman was hospitalized on April 25, 2018, at which time she had progressive dyspnea over the past 5 weeks, productive cough, poor appetite, and weight loss of 5 kg over the last 6 months currently weighing 81 kg. Her medical history included an invasive ductal breast cancer pT1cN0M0 G2 ER 90%, PR 20% 20 y... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 60-year-old gentleman with past medical history of cervical disk herniation presented with a 3-year history of progressive fatigue and bilateral upper extremity weakness. MRI was performed to evaluate the spine and was consistent with cervical spinal stenosis. T2 non-contrast images incidentally revealed an infiltrat... | A 52-year-old woman was referred to our hospital because of severe dyspnea and the presence of a neck tumor. She had experienced dyspnea for the past 6 months and had recently noticed bloody sputum. A computed tomography examination of the neck revealed a thyroid tumor about 8 cm in size. The tumor had invaded the trac... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 60-year-old gentleman with past medical history of cervical disk herniation presented with a 3-year history of progressive fatigue and bilateral upper extremity weakness. MRI was performed to evaluate the spine and was consistent with cervical spinal stenosis. T2 non-contrast images incidentally revealed an infiltrat... | A 76-year-old man was referred to our hospital for investigation of a 20-day history of rapidly deteriorating dyspnea and severe cough. This was associated with dysphagia and cervical pain. The patient was an ex-marble craftsman and an active smoker. His medical history included chronic pulmonary obstructive disease (C... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 60-year-old gentleman with past medical history of cervical disk herniation presented with a 3-year history of progressive fatigue and bilateral upper extremity weakness. MRI was performed to evaluate the spine and was consistent with cervical spinal stenosis. T2 non-contrast images incidentally revealed an infiltrat... | The patient, a 28-year-old man with a 3-month-old mass in the neck was referred to our department. The mass, located on the left thyroid lobe, was elastic, hard, showed limited mobility, and measured approximately 30 × 20 mm. There was no remarkable tenderness over the mass.\nBlood examination results were normal, incl... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 60-year-old gentleman with past medical history of cervical disk herniation presented with a 3-year history of progressive fatigue and bilateral upper extremity weakness. MRI was performed to evaluate the spine and was consistent with cervical spinal stenosis. T2 non-contrast images incidentally revealed an infiltrat... | A 60-year-old woman, who was diagnosed with cancer of the thyroid gland in 2015, was treated with total thyroidectomy and lymph node dissection. Her postoperative pathology showed carcinoma showing thymus-like differentiation (CASTLE). She was discharged on Levothyroxine 100 mg/day. She did not attend her follow-up app... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 34-year-old woman presented with a 2-month history of sore throat. The patient had no notable medical or family history. Physical examination revealed a palpable right thyroid mass. Thyroid function and calcium tests were within normal limits. Ultrasound showed a 1.7-cm, well demarcated, heterogeneous, low echoic sol... | Patient 2 was a 48-year-old male pathologically diagnosed with stage pT4aN0M0 CASTLE postsurgery. He presented with rapidly growing thyroid nodules with fixation to underlying structures. He underwent total thyroidectomy with central neck dissection. On exploration, the thyroid mass was seen extended to the left laryng... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 79-year old woman was hospitalized on April 25, 2018, at which time she had progressive dyspnea over the past 5 weeks, productive cough, poor appetite, and weight loss of 5 kg over the last 6 months currently weighing 81 kg. Her medical history included an invasive ductal breast cancer pT1cN0M0 G2 ER 90%, PR 20% 20 y... | Patient 2 was a 48-year-old male pathologically diagnosed with stage pT4aN0M0 CASTLE postsurgery. He presented with rapidly growing thyroid nodules with fixation to underlying structures. He underwent total thyroidectomy with central neck dissection. On exploration, the thyroid mass was seen extended to the left laryng... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 52-year-old woman was referred to our hospital because of severe dyspnea and the presence of a neck tumor. She had experienced dyspnea for the past 6 months and had recently noticed bloody sputum. A computed tomography examination of the neck revealed a thyroid tumor about 8 cm in size. The tumor had invaded the trac... | Patient 2 was a 48-year-old male pathologically diagnosed with stage pT4aN0M0 CASTLE postsurgery. He presented with rapidly growing thyroid nodules with fixation to underlying structures. He underwent total thyroidectomy with central neck dissection. On exploration, the thyroid mass was seen extended to the left laryng... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 76-year-old man was referred to our hospital for investigation of a 20-day history of rapidly deteriorating dyspnea and severe cough. This was associated with dysphagia and cervical pain. The patient was an ex-marble craftsman and an active smoker. His medical history included chronic pulmonary obstructive disease (C... | Patient 2 was a 48-year-old male pathologically diagnosed with stage pT4aN0M0 CASTLE postsurgery. He presented with rapidly growing thyroid nodules with fixation to underlying structures. He underwent total thyroidectomy with central neck dissection. On exploration, the thyroid mass was seen extended to the left laryng... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
The patient, a 28-year-old man with a 3-month-old mass in the neck was referred to our department. The mass, located on the left thyroid lobe, was elastic, hard, showed limited mobility, and measured approximately 30 × 20 mm. There was no remarkable tenderness over the mass.\nBlood examination results were normal, incl... | Patient 2 was a 48-year-old male pathologically diagnosed with stage pT4aN0M0 CASTLE postsurgery. He presented with rapidly growing thyroid nodules with fixation to underlying structures. He underwent total thyroidectomy with central neck dissection. On exploration, the thyroid mass was seen extended to the left laryng... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 60-year-old woman, who was diagnosed with cancer of the thyroid gland in 2015, was treated with total thyroidectomy and lymph node dissection. Her postoperative pathology showed carcinoma showing thymus-like differentiation (CASTLE). She was discharged on Levothyroxine 100 mg/day. She did not attend her follow-up app... | Patient 2 was a 48-year-old male pathologically diagnosed with stage pT4aN0M0 CASTLE postsurgery. He presented with rapidly growing thyroid nodules with fixation to underlying structures. He underwent total thyroidectomy with central neck dissection. On exploration, the thyroid mass was seen extended to the left laryng... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 34-year-old woman presented with a 2-month history of sore throat. The patient had no notable medical or family history. Physical examination revealed a palpable right thyroid mass. Thyroid function and calcium tests were within normal limits. Ultrasound showed a 1.7-cm, well demarcated, heterogeneous, low echoic sol... | A 79-year old woman was hospitalized on April 25, 2018, at which time she had progressive dyspnea over the past 5 weeks, productive cough, poor appetite, and weight loss of 5 kg over the last 6 months currently weighing 81 kg. Her medical history included an invasive ductal breast cancer pT1cN0M0 G2 ER 90%, PR 20% 20 y... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 34-year-old woman presented with a 2-month history of sore throat. The patient had no notable medical or family history. Physical examination revealed a palpable right thyroid mass. Thyroid function and calcium tests were within normal limits. Ultrasound showed a 1.7-cm, well demarcated, heterogeneous, low echoic sol... | A 52-year-old woman was referred to our hospital because of severe dyspnea and the presence of a neck tumor. She had experienced dyspnea for the past 6 months and had recently noticed bloody sputum. A computed tomography examination of the neck revealed a thyroid tumor about 8 cm in size. The tumor had invaded the trac... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 34-year-old woman presented with a 2-month history of sore throat. The patient had no notable medical or family history. Physical examination revealed a palpable right thyroid mass. Thyroid function and calcium tests were within normal limits. Ultrasound showed a 1.7-cm, well demarcated, heterogeneous, low echoic sol... | A 76-year-old man was referred to our hospital for investigation of a 20-day history of rapidly deteriorating dyspnea and severe cough. This was associated with dysphagia and cervical pain. The patient was an ex-marble craftsman and an active smoker. His medical history included chronic pulmonary obstructive disease (C... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 34-year-old woman presented with a 2-month history of sore throat. The patient had no notable medical or family history. Physical examination revealed a palpable right thyroid mass. Thyroid function and calcium tests were within normal limits. Ultrasound showed a 1.7-cm, well demarcated, heterogeneous, low echoic sol... | The patient, a 28-year-old man with a 3-month-old mass in the neck was referred to our department. The mass, located on the left thyroid lobe, was elastic, hard, showed limited mobility, and measured approximately 30 × 20 mm. There was no remarkable tenderness over the mass.\nBlood examination results were normal, incl... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 34-year-old woman presented with a 2-month history of sore throat. The patient had no notable medical or family history. Physical examination revealed a palpable right thyroid mass. Thyroid function and calcium tests were within normal limits. Ultrasound showed a 1.7-cm, well demarcated, heterogeneous, low echoic sol... | A 60-year-old woman, who was diagnosed with cancer of the thyroid gland in 2015, was treated with total thyroidectomy and lymph node dissection. Her postoperative pathology showed carcinoma showing thymus-like differentiation (CASTLE). She was discharged on Levothyroxine 100 mg/day. She did not attend her follow-up app... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 79-year old woman was hospitalized on April 25, 2018, at which time she had progressive dyspnea over the past 5 weeks, productive cough, poor appetite, and weight loss of 5 kg over the last 6 months currently weighing 81 kg. Her medical history included an invasive ductal breast cancer pT1cN0M0 G2 ER 90%, PR 20% 20 y... | A 52-year-old woman was referred to our hospital because of severe dyspnea and the presence of a neck tumor. She had experienced dyspnea for the past 6 months and had recently noticed bloody sputum. A computed tomography examination of the neck revealed a thyroid tumor about 8 cm in size. The tumor had invaded the trac... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 79-year old woman was hospitalized on April 25, 2018, at which time she had progressive dyspnea over the past 5 weeks, productive cough, poor appetite, and weight loss of 5 kg over the last 6 months currently weighing 81 kg. Her medical history included an invasive ductal breast cancer pT1cN0M0 G2 ER 90%, PR 20% 20 y... | A 76-year-old man was referred to our hospital for investigation of a 20-day history of rapidly deteriorating dyspnea and severe cough. This was associated with dysphagia and cervical pain. The patient was an ex-marble craftsman and an active smoker. His medical history included chronic pulmonary obstructive disease (C... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 79-year old woman was hospitalized on April 25, 2018, at which time she had progressive dyspnea over the past 5 weeks, productive cough, poor appetite, and weight loss of 5 kg over the last 6 months currently weighing 81 kg. Her medical history included an invasive ductal breast cancer pT1cN0M0 G2 ER 90%, PR 20% 20 y... | The patient, a 28-year-old man with a 3-month-old mass in the neck was referred to our department. The mass, located on the left thyroid lobe, was elastic, hard, showed limited mobility, and measured approximately 30 × 20 mm. There was no remarkable tenderness over the mass.\nBlood examination results were normal, incl... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 79-year old woman was hospitalized on April 25, 2018, at which time she had progressive dyspnea over the past 5 weeks, productive cough, poor appetite, and weight loss of 5 kg over the last 6 months currently weighing 81 kg. Her medical history included an invasive ductal breast cancer pT1cN0M0 G2 ER 90%, PR 20% 20 y... | A 60-year-old woman, who was diagnosed with cancer of the thyroid gland in 2015, was treated with total thyroidectomy and lymph node dissection. Her postoperative pathology showed carcinoma showing thymus-like differentiation (CASTLE). She was discharged on Levothyroxine 100 mg/day. She did not attend her follow-up app... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 52-year-old woman was referred to our hospital because of severe dyspnea and the presence of a neck tumor. She had experienced dyspnea for the past 6 months and had recently noticed bloody sputum. A computed tomography examination of the neck revealed a thyroid tumor about 8 cm in size. The tumor had invaded the trac... | A 76-year-old man was referred to our hospital for investigation of a 20-day history of rapidly deteriorating dyspnea and severe cough. This was associated with dysphagia and cervical pain. The patient was an ex-marble craftsman and an active smoker. His medical history included chronic pulmonary obstructive disease (C... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 52-year-old woman was referred to our hospital because of severe dyspnea and the presence of a neck tumor. She had experienced dyspnea for the past 6 months and had recently noticed bloody sputum. A computed tomography examination of the neck revealed a thyroid tumor about 8 cm in size. The tumor had invaded the trac... | The patient, a 28-year-old man with a 3-month-old mass in the neck was referred to our department. The mass, located on the left thyroid lobe, was elastic, hard, showed limited mobility, and measured approximately 30 × 20 mm. There was no remarkable tenderness over the mass.\nBlood examination results were normal, incl... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 52-year-old woman was referred to our hospital because of severe dyspnea and the presence of a neck tumor. She had experienced dyspnea for the past 6 months and had recently noticed bloody sputum. A computed tomography examination of the neck revealed a thyroid tumor about 8 cm in size. The tumor had invaded the trac... | A 60-year-old woman, who was diagnosed with cancer of the thyroid gland in 2015, was treated with total thyroidectomy and lymph node dissection. Her postoperative pathology showed carcinoma showing thymus-like differentiation (CASTLE). She was discharged on Levothyroxine 100 mg/day. She did not attend her follow-up app... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 76-year-old man was referred to our hospital for investigation of a 20-day history of rapidly deteriorating dyspnea and severe cough. This was associated with dysphagia and cervical pain. The patient was an ex-marble craftsman and an active smoker. His medical history included chronic pulmonary obstructive disease (C... | The patient, a 28-year-old man with a 3-month-old mass in the neck was referred to our department. The mass, located on the left thyroid lobe, was elastic, hard, showed limited mobility, and measured approximately 30 × 20 mm. There was no remarkable tenderness over the mass.\nBlood examination results were normal, incl... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
A 76-year-old man was referred to our hospital for investigation of a 20-day history of rapidly deteriorating dyspnea and severe cough. This was associated with dysphagia and cervical pain. The patient was an ex-marble craftsman and an active smoker. His medical history included chronic pulmonary obstructive disease (C... | A 60-year-old woman, who was diagnosed with cancer of the thyroid gland in 2015, was treated with total thyroidectomy and lymph node dissection. Her postoperative pathology showed carcinoma showing thymus-like differentiation (CASTLE). She was discharged on Levothyroxine 100 mg/day. She did not attend her follow-up app... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
The patient, a 28-year-old man with a 3-month-old mass in the neck was referred to our department. The mass, located on the left thyroid lobe, was elastic, hard, showed limited mobility, and measured approximately 30 × 20 mm. There was no remarkable tenderness over the mass.\nBlood examination results were normal, incl... | A 60-year-old woman, who was diagnosed with cancer of the thyroid gland in 2015, was treated with total thyroidectomy and lymph node dissection. Her postoperative pathology showed carcinoma showing thymus-like differentiation (CASTLE). She was discharged on Levothyroxine 100 mg/day. She did not attend her follow-up app... | 1 | Write a detailed clinical case vignette based on the following key phrases: Thyroid Cancer, CASTLE (Carcinoma showing Thymus-like Differentiation), Neck Mass |
Case 4 is a 42 years old male born in the jungle of Cusco state married with case 3. He was admitted to the hospital with fever, diffuse abdominal pain, cough, severe fatigue, 5 kg weight loss, rash in the lower extremities and buttocks, and hypereosinophilia (eosinophil count > 30,000/dL). Lumbreras rapid sedimentatio... | Case 7 was a 36 years old woman mother of case 5 diagnosed with chronic F. hepatica infection. She received 3 courses of triclabendazole (2 doses of 10 mg/kg every 12 hours) followed by a course of 2 doses of triclabendazole 10 mg/kg every 12 hours combined with nitaxozanide 500 mg every 12 hours for 7 days with persis... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 4 is a 42 years old male born in the jungle of Cusco state married with case 3. He was admitted to the hospital with fever, diffuse abdominal pain, cough, severe fatigue, 5 kg weight loss, rash in the lower extremities and buttocks, and hypereosinophilia (eosinophil count > 30,000/dL). Lumbreras rapid sedimentatio... | Case 5 was a 15 years old male who presented with epigastric pain, fever, shortness of breath, chest pain, 5 kg weight loss, hypereosinophilia, ascites, and pleural effusion. The stool tests for Fasciola were initially negative, but the Fas2 ELISA was positive. He was treated with a single dose of veterinary formulatio... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 4 is a 42 years old male born in the jungle of Cusco state married with case 3. He was admitted to the hospital with fever, diffuse abdominal pain, cough, severe fatigue, 5 kg weight loss, rash in the lower extremities and buttocks, and hypereosinophilia (eosinophil count > 30,000/dL). Lumbreras rapid sedimentatio... | Case 6 was a 12 years old male brother of case 5 diagnosed with asymptomatic F. hepatica infection. He failed the initial treatment with a single dose of triclabendazole. He was prescribed and failed 2 additional triclabendazole courses (2 doses of 10 mg/kg every 12 hours). He was subsequently treated with 2 doses of t... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 4 is a 42 years old male born in the jungle of Cusco state married with case 3. He was admitted to the hospital with fever, diffuse abdominal pain, cough, severe fatigue, 5 kg weight loss, rash in the lower extremities and buttocks, and hypereosinophilia (eosinophil count > 30,000/dL). Lumbreras rapid sedimentatio... | Case 2 was a 36 years old female with right upper quadrant abdominal pain, jaundice, severe joint pain, fatigue, 8 kg weight loss, and hypereosinophilia. Her stool tests and Fas-2 ELISA were positive for Fasciola. After failing a treatment course with triclabendazole (2 doses of 10 mg/kg every 12 hours), she was referr... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 4 is a 42 years old male born in the jungle of Cusco state married with case 3. He was admitted to the hospital with fever, diffuse abdominal pain, cough, severe fatigue, 5 kg weight loss, rash in the lower extremities and buttocks, and hypereosinophilia (eosinophil count > 30,000/dL). Lumbreras rapid sedimentatio... | Case 3 was a 43 years old female who was asymptomatic. She was tested for Fasciola hepatica ova after her husband (case 4) was diagnosed with the infection. Both Fas2 ELISA and stool tests were positive for Fasciola infection. She failed a course of triclabendazole (2 doses of 10 mg/kg every 12 hours) and was prescribe... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 4 is a 42 years old male born in the jungle of Cusco state married with case 3. He was admitted to the hospital with fever, diffuse abdominal pain, cough, severe fatigue, 5 kg weight loss, rash in the lower extremities and buttocks, and hypereosinophilia (eosinophil count > 30,000/dL). Lumbreras rapid sedimentatio... | Case 1 was a 51 years old female farmer with 16 kg weight loss, right upper quadrant abdominal pain, night sweats, anorexia, malaise, fever, and hypereosinophilia. She was first treated with a single dose of 10 mg/kg triclabendazole with improvement of symptoms. However, after 8 months her symptoms returned and she was... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 5 was a 15 years old male who presented with epigastric pain, fever, shortness of breath, chest pain, 5 kg weight loss, hypereosinophilia, ascites, and pleural effusion. The stool tests for Fasciola were initially negative, but the Fas2 ELISA was positive. He was treated with a single dose of veterinary formulatio... | Case 7 was a 36 years old woman mother of case 5 diagnosed with chronic F. hepatica infection. She received 3 courses of triclabendazole (2 doses of 10 mg/kg every 12 hours) followed by a course of 2 doses of triclabendazole 10 mg/kg every 12 hours combined with nitaxozanide 500 mg every 12 hours for 7 days with persis... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 6 was a 12 years old male brother of case 5 diagnosed with asymptomatic F. hepatica infection. He failed the initial treatment with a single dose of triclabendazole. He was prescribed and failed 2 additional triclabendazole courses (2 doses of 10 mg/kg every 12 hours). He was subsequently treated with 2 doses of t... | Case 7 was a 36 years old woman mother of case 5 diagnosed with chronic F. hepatica infection. She received 3 courses of triclabendazole (2 doses of 10 mg/kg every 12 hours) followed by a course of 2 doses of triclabendazole 10 mg/kg every 12 hours combined with nitaxozanide 500 mg every 12 hours for 7 days with persis... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 2 was a 36 years old female with right upper quadrant abdominal pain, jaundice, severe joint pain, fatigue, 8 kg weight loss, and hypereosinophilia. Her stool tests and Fas-2 ELISA were positive for Fasciola. After failing a treatment course with triclabendazole (2 doses of 10 mg/kg every 12 hours), she was referr... | Case 7 was a 36 years old woman mother of case 5 diagnosed with chronic F. hepatica infection. She received 3 courses of triclabendazole (2 doses of 10 mg/kg every 12 hours) followed by a course of 2 doses of triclabendazole 10 mg/kg every 12 hours combined with nitaxozanide 500 mg every 12 hours for 7 days with persis... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 3 was a 43 years old female who was asymptomatic. She was tested for Fasciola hepatica ova after her husband (case 4) was diagnosed with the infection. Both Fas2 ELISA and stool tests were positive for Fasciola infection. She failed a course of triclabendazole (2 doses of 10 mg/kg every 12 hours) and was prescribe... | Case 7 was a 36 years old woman mother of case 5 diagnosed with chronic F. hepatica infection. She received 3 courses of triclabendazole (2 doses of 10 mg/kg every 12 hours) followed by a course of 2 doses of triclabendazole 10 mg/kg every 12 hours combined with nitaxozanide 500 mg every 12 hours for 7 days with persis... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 1 was a 51 years old female farmer with 16 kg weight loss, right upper quadrant abdominal pain, night sweats, anorexia, malaise, fever, and hypereosinophilia. She was first treated with a single dose of 10 mg/kg triclabendazole with improvement of symptoms. However, after 8 months her symptoms returned and she was... | Case 7 was a 36 years old woman mother of case 5 diagnosed with chronic F. hepatica infection. She received 3 courses of triclabendazole (2 doses of 10 mg/kg every 12 hours) followed by a course of 2 doses of triclabendazole 10 mg/kg every 12 hours combined with nitaxozanide 500 mg every 12 hours for 7 days with persis... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 5 was a 15 years old male who presented with epigastric pain, fever, shortness of breath, chest pain, 5 kg weight loss, hypereosinophilia, ascites, and pleural effusion. The stool tests for Fasciola were initially negative, but the Fas2 ELISA was positive. He was treated with a single dose of veterinary formulatio... | Case 6 was a 12 years old male brother of case 5 diagnosed with asymptomatic F. hepatica infection. He failed the initial treatment with a single dose of triclabendazole. He was prescribed and failed 2 additional triclabendazole courses (2 doses of 10 mg/kg every 12 hours). He was subsequently treated with 2 doses of t... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 2 was a 36 years old female with right upper quadrant abdominal pain, jaundice, severe joint pain, fatigue, 8 kg weight loss, and hypereosinophilia. Her stool tests and Fas-2 ELISA were positive for Fasciola. After failing a treatment course with triclabendazole (2 doses of 10 mg/kg every 12 hours), she was referr... | Case 5 was a 15 years old male who presented with epigastric pain, fever, shortness of breath, chest pain, 5 kg weight loss, hypereosinophilia, ascites, and pleural effusion. The stool tests for Fasciola were initially negative, but the Fas2 ELISA was positive. He was treated with a single dose of veterinary formulatio... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 5 was a 15 years old male who presented with epigastric pain, fever, shortness of breath, chest pain, 5 kg weight loss, hypereosinophilia, ascites, and pleural effusion. The stool tests for Fasciola were initially negative, but the Fas2 ELISA was positive. He was treated with a single dose of veterinary formulatio... | Case 3 was a 43 years old female who was asymptomatic. She was tested for Fasciola hepatica ova after her husband (case 4) was diagnosed with the infection. Both Fas2 ELISA and stool tests were positive for Fasciola infection. She failed a course of triclabendazole (2 doses of 10 mg/kg every 12 hours) and was prescribe... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 1 was a 51 years old female farmer with 16 kg weight loss, right upper quadrant abdominal pain, night sweats, anorexia, malaise, fever, and hypereosinophilia. She was first treated with a single dose of 10 mg/kg triclabendazole with improvement of symptoms. However, after 8 months her symptoms returned and she was... | Case 5 was a 15 years old male who presented with epigastric pain, fever, shortness of breath, chest pain, 5 kg weight loss, hypereosinophilia, ascites, and pleural effusion. The stool tests for Fasciola were initially negative, but the Fas2 ELISA was positive. He was treated with a single dose of veterinary formulatio... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 2 was a 36 years old female with right upper quadrant abdominal pain, jaundice, severe joint pain, fatigue, 8 kg weight loss, and hypereosinophilia. Her stool tests and Fas-2 ELISA were positive for Fasciola. After failing a treatment course with triclabendazole (2 doses of 10 mg/kg every 12 hours), she was referr... | Case 6 was a 12 years old male brother of case 5 diagnosed with asymptomatic F. hepatica infection. He failed the initial treatment with a single dose of triclabendazole. He was prescribed and failed 2 additional triclabendazole courses (2 doses of 10 mg/kg every 12 hours). He was subsequently treated with 2 doses of t... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 3 was a 43 years old female who was asymptomatic. She was tested for Fasciola hepatica ova after her husband (case 4) was diagnosed with the infection. Both Fas2 ELISA and stool tests were positive for Fasciola infection. She failed a course of triclabendazole (2 doses of 10 mg/kg every 12 hours) and was prescribe... | Case 6 was a 12 years old male brother of case 5 diagnosed with asymptomatic F. hepatica infection. He failed the initial treatment with a single dose of triclabendazole. He was prescribed and failed 2 additional triclabendazole courses (2 doses of 10 mg/kg every 12 hours). He was subsequently treated with 2 doses of t... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 1 was a 51 years old female farmer with 16 kg weight loss, right upper quadrant abdominal pain, night sweats, anorexia, malaise, fever, and hypereosinophilia. She was first treated with a single dose of 10 mg/kg triclabendazole with improvement of symptoms. However, after 8 months her symptoms returned and she was... | Case 6 was a 12 years old male brother of case 5 diagnosed with asymptomatic F. hepatica infection. He failed the initial treatment with a single dose of triclabendazole. He was prescribed and failed 2 additional triclabendazole courses (2 doses of 10 mg/kg every 12 hours). He was subsequently treated with 2 doses of t... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 2 was a 36 years old female with right upper quadrant abdominal pain, jaundice, severe joint pain, fatigue, 8 kg weight loss, and hypereosinophilia. Her stool tests and Fas-2 ELISA were positive for Fasciola. After failing a treatment course with triclabendazole (2 doses of 10 mg/kg every 12 hours), she was referr... | Case 3 was a 43 years old female who was asymptomatic. She was tested for Fasciola hepatica ova after her husband (case 4) was diagnosed with the infection. Both Fas2 ELISA and stool tests were positive for Fasciola infection. She failed a course of triclabendazole (2 doses of 10 mg/kg every 12 hours) and was prescribe... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 2 was a 36 years old female with right upper quadrant abdominal pain, jaundice, severe joint pain, fatigue, 8 kg weight loss, and hypereosinophilia. Her stool tests and Fas-2 ELISA were positive for Fasciola. After failing a treatment course with triclabendazole (2 doses of 10 mg/kg every 12 hours), she was referr... | Case 1 was a 51 years old female farmer with 16 kg weight loss, right upper quadrant abdominal pain, night sweats, anorexia, malaise, fever, and hypereosinophilia. She was first treated with a single dose of 10 mg/kg triclabendazole with improvement of symptoms. However, after 8 months her symptoms returned and she was... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
Case 1 was a 51 years old female farmer with 16 kg weight loss, right upper quadrant abdominal pain, night sweats, anorexia, malaise, fever, and hypereosinophilia. She was first treated with a single dose of 10 mg/kg triclabendazole with improvement of symptoms. However, after 8 months her symptoms returned and she was... | Case 3 was a 43 years old female who was asymptomatic. She was tested for Fasciola hepatica ova after her husband (case 4) was diagnosed with the infection. Both Fas2 ELISA and stool tests were positive for Fasciola infection. She failed a course of triclabendazole (2 doses of 10 mg/kg every 12 hours) and was prescribe... | 2 | Write a detailed clinical case vignette based on the following key phrases: Fasciola hepatica infection, Triclabendazole treatment, Treatment failure |
This is a 65-year-old man known to have chronic myeloid leukemia (CML) on dasatinib. He presented with a short history of fever, productive cough, and dyspnea. The examination revealed low-grade fever, tachycardia, and bilateral rhonchi on chest examination. Chest X-ray showed bilateral lower lobe consolidation with ef... | The first case is a 74-year-old man known to have asthma, diabetes mellitus (DM), hypertension (HTN), coronary artery disease (CAD), and dyslipidemia (). He was admitted to a quarantine facility because of an asymptomatic COVID-19 infection identified through screening (RT-PCR). The local guideline at the time warrante... | 3 | Write a detailed clinical case vignette based on the following key phrases: COVID-19, Prolonged PCR positivity, Recovery and discharge |
This is a 65-year-old man known to have chronic myeloid leukemia (CML) on dasatinib. He presented with a short history of fever, productive cough, and dyspnea. The examination revealed low-grade fever, tachycardia, and bilateral rhonchi on chest examination. Chest X-ray showed bilateral lower lobe consolidation with ef... | A previously healthy 46-year-old man presented with a 7-day history of fever, dry cough, and mild dyspnea. On examination, he was febrile, mildly tachypneic, tachycardic, but maintained oxygen saturation on room air. His chest X-ray revealed consolidation involving the left mid and lower zones. SARS-CoV-2 PCR tested po... | 3 | Write a detailed clinical case vignette based on the following key phrases: COVID-19, Prolonged PCR positivity, Recovery and discharge |
This is a 65-year-old man known to have chronic myeloid leukemia (CML) on dasatinib. He presented with a short history of fever, productive cough, and dyspnea. The examination revealed low-grade fever, tachycardia, and bilateral rhonchi on chest examination. Chest X-ray showed bilateral lower lobe consolidation with ef... | A healthy 19-year-old man presented with a short history of fever and sore throat. The examination was remarkable for low-grade fever and tachycardia, and laboratory investigations and chest X-ray were unremarkable. He was diagnosed as a case of COVID-19 mild URTI and did not require hospital admission but transited th... | 3 | Write a detailed clinical case vignette based on the following key phrases: COVID-19, Prolonged PCR positivity, Recovery and discharge |
A 53-year-old man, known to have HTN, DM, and end-stage renal disease (ESRD), presented with fever, abdominal pain, diarrhea, nausea, and vomiting. Physical examination revealed a tired-looking man with mild abdominal tenderness but was otherwise unremarkable. Abdominal computed tomography (CT) scan was performed to ru... | This is a 65-year-old man known to have chronic myeloid leukemia (CML) on dasatinib. He presented with a short history of fever, productive cough, and dyspnea. The examination revealed low-grade fever, tachycardia, and bilateral rhonchi on chest examination. Chest X-ray showed bilateral lower lobe consolidation with ef... | 3 | Write a detailed clinical case vignette based on the following key phrases: COVID-19, Prolonged PCR positivity, Recovery and discharge |
This is a 65-year-old man known to have chronic myeloid leukemia (CML) on dasatinib. He presented with a short history of fever, productive cough, and dyspnea. The examination revealed low-grade fever, tachycardia, and bilateral rhonchi on chest examination. Chest X-ray showed bilateral lower lobe consolidation with ef... | A 35-year-old man presented with a 10-day history of fever, headache, and dry cough. Physical examination was unremarkable. His baseline blood investigation was remarkable for high inflammatory markers and mild transaminitis. Chest X-ray revealed left mid-zone consolidation with a cavitary lesion. He was found to be po... | 3 | Write a detailed clinical case vignette based on the following key phrases: COVID-19, Prolonged PCR positivity, Recovery and discharge |
A previously healthy 46-year-old man presented with a 7-day history of fever, dry cough, and mild dyspnea. On examination, he was febrile, mildly tachypneic, tachycardic, but maintained oxygen saturation on room air. His chest X-ray revealed consolidation involving the left mid and lower zones. SARS-CoV-2 PCR tested po... | The first case is a 74-year-old man known to have asthma, diabetes mellitus (DM), hypertension (HTN), coronary artery disease (CAD), and dyslipidemia (). He was admitted to a quarantine facility because of an asymptomatic COVID-19 infection identified through screening (RT-PCR). The local guideline at the time warrante... | 3 | Write a detailed clinical case vignette based on the following key phrases: COVID-19, Prolonged PCR positivity, Recovery and discharge |
The first case is a 74-year-old man known to have asthma, diabetes mellitus (DM), hypertension (HTN), coronary artery disease (CAD), and dyslipidemia (). He was admitted to a quarantine facility because of an asymptomatic COVID-19 infection identified through screening (RT-PCR). The local guideline at the time warrante... | A healthy 19-year-old man presented with a short history of fever and sore throat. The examination was remarkable for low-grade fever and tachycardia, and laboratory investigations and chest X-ray were unremarkable. He was diagnosed as a case of COVID-19 mild URTI and did not require hospital admission but transited th... | 3 | Write a detailed clinical case vignette based on the following key phrases: COVID-19, Prolonged PCR positivity, Recovery and discharge |
A 53-year-old man, known to have HTN, DM, and end-stage renal disease (ESRD), presented with fever, abdominal pain, diarrhea, nausea, and vomiting. Physical examination revealed a tired-looking man with mild abdominal tenderness but was otherwise unremarkable. Abdominal computed tomography (CT) scan was performed to ru... | The first case is a 74-year-old man known to have asthma, diabetes mellitus (DM), hypertension (HTN), coronary artery disease (CAD), and dyslipidemia (). He was admitted to a quarantine facility because of an asymptomatic COVID-19 infection identified through screening (RT-PCR). The local guideline at the time warrante... | 3 | Write a detailed clinical case vignette based on the following key phrases: COVID-19, Prolonged PCR positivity, Recovery and discharge |
A 35-year-old man presented with a 10-day history of fever, headache, and dry cough. Physical examination was unremarkable. His baseline blood investigation was remarkable for high inflammatory markers and mild transaminitis. Chest X-ray revealed left mid-zone consolidation with a cavitary lesion. He was found to be po... | The first case is a 74-year-old man known to have asthma, diabetes mellitus (DM), hypertension (HTN), coronary artery disease (CAD), and dyslipidemia (). He was admitted to a quarantine facility because of an asymptomatic COVID-19 infection identified through screening (RT-PCR). The local guideline at the time warrante... | 3 | Write a detailed clinical case vignette based on the following key phrases: COVID-19, Prolonged PCR positivity, Recovery and discharge |
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