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TOCKMAN", + "INCREASED RISK OF THROMBOSIS DUE TO ORAL CONTRACEPTIVES:", + "MAUREEN G. MAGUIRE, JAMES TONASCIA, PHILIP E. SARTWELL, PAUL D. STOLLEY AND", + "Maguire, M. G. (Dept. of Biostatistics, Johns Hopkins U. School of Hygiene", + "and Public Health, Baltimore, MD 21205), J. Tonascia, P. E. Sartwell, P. D.", + "Stolley and M. S. Tockman. Increased risk of thrombosis due to oral con-", + "traceptives: A further report. Am J Epidemiol 110:188-195, 1979.", + "In a previously reported case-control study of the relationship between oral", + "contraceptives and thromboembolism, there were 461 cases and 1302 controls,", + "individually matched on age, race, marital status, hospital, and date of admis-", + "sion. Initially, the control patients had not been matched with the cases for the", + "presence or absence of six factors thought to predispose to or precipitate", + "thromboembolic disease. The present paper reports the effects of taking into", + "consideration these factors in the controls. Two methods of analysis (matched", + "set, and logistic regression) gave closely similar results. Where the case series", + "consisted of idiopathic cases, the revised estimate of the relative risk was", + "reduced from 7.2 to 4.7 by these procedures; for predisposed cases, it was", + "increased from 1.2 to 2.2. The explanation suggested in the previous report for", + "the failure to find an increased risk for cases with predisposition receives", + "support from these findings. Variation in the relative risk was examined for four", + "separate diagnostic categories: venous thrombosis alone, pulmonary em-", + "bolism alone, venous thrombosis and pulmonary embolism together, and", + "myocardial infarction. The relative risk estimates were greater than unity for", + "each thrombosis category for both predisposed and non-predisposed cases.", + "The relative risk was not found to vary significantly according to age or smoking", + "status.", + "contraceptives, oral; myocardial infarct; pulmonary embolism; retrospective", + "studies; thromboembolism; thrombophlebitis", + "An earlier report (1) of a case-control", + "users in the idiopathic series and", + "study of the relationship of oral con-", + "twofold increase for the whole series. The", + "traception to thrombosis in 104 idiopathic", + "present report extends the earlier", + "cases, 357 other thrombosis cases (exclu-", + "analysis by giving consideration to the ef-", + "sive of cerebrovascular thrombosis) and", + "fects of factors which predispose to or pre-", + "1302 matched controls described a seven-", + "cipitate thrombosis on the relative risk", + "fold increase in risk for oral contraceptive", + "associated with oral contraceptive use,", + "Received for publication August 9, 1978, and in", + "of Hygiene and Public Health, 615 North Wolfe St.,", + "Baltimore, MD 21205.", + "final form January 26, 1979.", + "This work was supported by Grant No. 5-P01-", + "From The Johns Hopkins University School of", + "2", + "NS06229 from the National Institutes of Neurologi-", + "Hygiene and Public Health, Departments of Bio-", + "cal Disease and Stroke, Contract No. NIH-71-2296", + "statistics and Epidemiology, Baltimore, MD, and the", + "with the National Institutes of Health and Biomedi-", + "University of Pennsylvania, School of Medicine, De-", + "cal Research Support Grant FR-05445 from the", + "partment of Research Medicine, Philadelphia, PA.", + "Biomedical Research Support Branch. Division of", + ": Reprint requests to: Ms. Maguire, Department of", + "Research Facilities and Resources, National Insti-", + "Biostatistics, The Johns Hopkins University School", + "tutes of Health, Bethesda, MD.", + "188", + "Source: https://www.industrydocuments.ucsf.edu/docs/fmvh0034", + "Rug.", + "Vol 110. 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No. 2", + "ated in C.S.A.", + "tive risk of particular types of thrombosis", + "PTIVES:", + "diagnoses including the variation by", + "smoking and age.", + ".LEY AND", + "Complete details of the study popula-", + "tion and data collection methods may be", + "iene", + "found in the earlier report (1). The salient", + "P.D.", + "features may be summarized as follows:", + "con-", + "The study was a case-control (retrospec-", + "oral", + "tive) investigation of women with throm-", + "rois,", + "boembolic disease between the ages of 15", + "mis-", + "and 49 admitted to any of 37 collaborating", + "r the", + "hospitals during the study period from", + "tate", + "1970 to 1973. Cases were selected from", + "into", + "several diagnoses including pulmonary", + ":hed", + "embolism and infarction; phlebitis and", + "ries", + "thrombophlebitis of the lower extremities", + "was", + "and other sites; other venous embolism", + "was", + "and thrombosis; arterial embolism and", + "t for", + "thrombosis (excluding intracranial sites);", + "ives", + "four", + "and acute myocardial infarction. Women", + "em-", + "with strokes were excluded because of a", + "and", + "contemporaneous study in some of the", + "/ for", + "same institutions (2). Cases were accepted", + "ses.", + "even if they had predisposing or pre-", + "35", + "controls", + "group", + "cases", + "(/-ratio)", + "(I-ratio)", + "(t-ratio)", + "0.48", + "-0.47", + "0.09", + "(1.1)", + "(-0.91)", + "(0.17)", + "-0.94", + "2.2", + "- -1.0", + "(4.6)", + "(-1.6)", + "(-1.8)", + "1.9", + "-0.49", + "- -1.8", + "(1.2)", + "(-.32)", + "(-1.2)", + "2.2", + "-1.0", + "-0.30", + "(3.1)", + "(-1.3)", + "(-.28)", + "Disease", + "Predisposed group", + "Venous thrombosis only", + "150", + "670", + "86", + "670", + "28", + "670", + "45", + "632", + "- Covariable variables used in each model included age, marital status, years of admission, hospital", + "payment status, previous pregnancies, income level, employment setting, smoking. The myocardial infarc-", + "tion model also included presence of hypertension, presence of elevated cholesterol, and presence of diabetes.", + "excess mortality from circulatory diseases", + "associated with oral contraceptive use", + "and that this excess is multiplied by risks", + "associated with increasing age and", + "cigarette smoking. While the present data", + "on excess thrombotic morbidity do not", + "contradict a similar relationship, there", + "was a suggestion that the excess relative", + "risk associated with oral contraceptive", + "use decreases with smoking and age. Still", + "more data are required to clarify the rela-", + "tionship of age, smoking, and oral con-", + "traceptive use to thrombosis risk.", + "REFERENCES", + "1. Stolley PD, Tonascia JA, Tockman MS, et al:", + "Thrombosis with low-estrogen oral contracep-", + "tives. Am J Epidemiol 102:197-208, - 1975", + "2. Collaborative Group for the Study of Stroke in", + "Young Women: Oral contraception and in-", + "creased risk of cerebral ischemia or thrombosis.", + "N Engl J Med 288:871-878 -- 1973", + "3. Gart J: Point and interval estimation of the", + "common odds ratio in the combination of 2 x 2", + "tables with fixed marginals. Biometrika", + "57:471-475, 1970", + "4. Cox DR: Analysis of Binary Data. New York,", + "Methuen and Company, 1970", + "5. Prentice R: Use of the logistic model in retro-", + "spective studies. Biometrics 32:599- - 606. 1976", + "6. Sartwell PE, Masi AT, Arthes FG, et al: Throm-", + "boembolism and oral contraceptives: An", + "TI09680501", + "B.-", + "5." + ] + }, + { + "bbox": [ + [ + 0.411915, + 0.154606, + 0.322887, + 0.008546 + ], + [ + 0.853267, + 0.151819, + 0.024972, + 0.009918 + ], + [ + 0.283892, + 0.176301, + 0.275387, + 0.010879 + ], + [ + 0.602361, + 0.174969, + 0.277003, + 0.010577 + ], + [ + 0.284211, + 0.187793, + 0.16862, + 0.009916 + ], + [ + 0.602604, + 0.18643, + 0.098643, + 0.009259 + ], + [ + 0.267476, + 0.197924, + 0.29251, + 0.010842 + ], + [ + 0.585706, + 0.196445, + 0.294752, + 0.010609 + ], + [ + 0.286306, + 0.208638, + 0.274865, + 0.010978 + ], + [ + 0.603568, + 0.207497, + 0.276795, + 0.010439 + ], + [ + 0.286639, + 0.219818, + 0.195975, + 0.009153 + ], + [ + 0.603484, + 0.218397, + 0.277235, + 0.010525 + ], + [ + 0.268417, + 0.22987, + 0.292651, + 0.011031 + ], + [ + 0.603892, + 0.229345, + 0.184406, + 0.010079 + ], + [ + 0.042613, + 0.236678, + 0.05173, + 0.007402 + ], + [ + 0.068291, 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