| Year | Title | Role | Notes |
| 2001 | Crust | Receptionist | - |
| 2002 | Living In Hope | Ginny | - |
| 2002 | Anansi | Carla | - |
| 2002 | 28 Days Later | Selena | - |
| 2004 | Trauma | Elisa | - |
| 2004 | After the Sunset | Sophie | - |
| 2006 | Pirates of the Caribbean: Dead Man's Chest | Tia Dalma | - |
| 2006 | Miami Vice | Trudy Joplin | - |
| 2006 | A Cock and Bull Story | Jennie | - |
| 2007 | Pirates of the Caribbean: At World's End | Tia Dalma / Calypso | - |
| 2008 | Street Kings | Linda Washington | - |
| 2008 | Explicit Ills | Jill | - |
| 2008 | August | Sarah | - |
| 2009 | Morris: A Life with Bells On | Sonja | - |
| 2009 | Ninja Assassin | Mika Coretti | - |
| 2009 | Sex & Drugs & Rock & Roll | Denise | - |
| 2009 | My Last Five Girlfriends | Gemma | - |
| 2010 | The First Grader | Jane Obinchu | - |
| 2012 | Skyfall | Eve Moneypenny | - |
| 2013 | Mandela: Long Walk to Freedom | Winnie Mandela | - |
| 2015 | Southpaw | Angela Rivera | - |
| 2015 | Spectre | Eve Moneypenny | - |
| 2016 | Our Kind of Traitor | Gail Perkins | - |
| 2016 | Moonlight | Paula | - |
| 2016 | Collateral Beauty | Madeleine | - |
| 2018 | Rampage | Dr. Kate Caldwell | - |
| 2018 | Mowgli: Legend of the Jungle | Nisha | Motion-capture and voice |
| 2019 | Black and Blue | - | Post-production |
| 2020 | Bond 25 | Eve Moneypenny | Filming |