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{"drug_name":[{"name":"Doravirine/Islatravir","lang":"EN"},{"name":"ドラビリン/イスラトラビル水和物","lang":"JP"}],"alias":[{"name":"DOR/ISL","lang":"EN"},{"name":"Doravirine/Islatravir Hydrate","lang":"EN"},{"name":"Islatravir/doravirine","lang":"EN"}],"target":[[{"name":"Viral reverse transcriptase","lang":"EN"},{"name":"逆转录酶","lang":"CN"}]],"disease":[[{"name":"HIV Infections","lang":"EN"},{"name":"HIV感染","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Approved","first_approved_date":1772755200000,"first_approved_indication":[[{"name":"HIV Infections","lang":"EN"},{"name":"HIV感染","lang":"CN"}]],"approval_country":["United States","Japan"]}
{"drug_name":[{"name":"赛特美拉诺肽","lang":"CN"},{"name":"Setmelanotide Acetate","lang":"EN"}],"target":[[{"name":"Melanocortin receptor 4","lang":"EN"},{"name":"黑素皮质素受体4","lang":"CN"}]],"disease":[[{"name":"Hypothalamic obesity","lang":"EN"},{"name":"下丘脑性肥胖症","lang":"CN"}],[{"name":"Bardet-Biedl Syndrome","lang":"EN"},{"name":"巴德-比德尔综合征","lang":"CN"}],[{"name":"Proopiomelanocortin Deficiency","lang":"EN"},{"name":"阿黑皮素原缺乏症 ","lang":"CN"}],[{"name":"Obesity","lang":"EN"},{"name":"肥胖","lang":"CN"}],[{"name":"Combined Pituitary Hormone Deficiency","lang":"EN"},{"name":"合并垂体激素缺乏症","lang":"CN"}],[{"name":"Optic Nerve Hypoplasia","lang":"EN"},{"name":"视神经发育不全","lang":"CN"}],[{"name":"Septo-Optic Dysplasia","lang":"EN"},{"name":"透明隔-视神经发育不良","lang":"CN"}],[{"name":"Pediatric Obesity","lang":"EN"},{"name":"儿童肥胖","lang":"CN"}],[{"name":"Prader-Willi Syndrome","lang":"EN"},{"name":"普拉德-威利综合症","lang":"CN"}],[{"name":"Alstrom Syndrome","lang":"EN"},{"name":"Alstrom综合征","lang":"CN"}],[{"name":"Autoimmune Diseases","lang":"EN"},{"name":"自身免疫性疾病","lang":"CN"}],[{"name":"Diabetes Mellitus, Type 1","lang":"EN"},{"name":"1型糖尿病","lang":"CN"}],[{"name":"Hypertriglyceridemia","lang":"EN"},{"name":"高甘油三酯血症","lang":"CN"}],[{"name":"Leptin Deficiency","lang":"EN"},{"name":"瘦素缺乏","lang":"CN"}],[{"name":"Leptin Receptor Deficiency","lang":"EN"},{"name":"瘦素受体缺乏","lang":"CN"}],[{"name":"Lipodystrophy, Partial, Acquired","lang":"EN"},{"name":"获得性部分脂肪营养不良","lang":"CN"}],[{"name":"Obesity due to melanocortin 4 receptor deficiency","lang":"EN"},{"name":"黑皮质素4受体缺乏导致的肥胖","lang":"CN"}],[{"name":"Obesity, Morbid","lang":"EN"},{"name":"病态肥胖","lang":"CN"}],[{"name":"Smith-Magenis Syndrome","lang":"EN"},{"name":"Smith-Magenis综合征","lang":"CN"}]],"drug_type":["Synthetic peptide","Cyclic Peptide"],"global_highest_dev_status":"Pending","first_approved_date":1606262400000,"first_approved_indication":[[{"name":"Obesity","lang":"EN"},{"name":"肥胖","lang":"CN"}]],"approval_country":["United States","European Union","United Kingdom","Canada","Iceland","Liechtenstein","Norway"]}
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{"drug_name":[{"name":"重组三价新冠病毒（XBB+BA.5+Delta 变异株）三聚体蛋白疫苗（Sf9细胞）","lang":"CN"},{"name":"Recombinant COVID-19 Trivalent (XBB+BA.5+Delta) Protein Vaccine(Sf9 Cell) (WestVac Biopharma)","lang":"EN"}],"alias":[{"name":"Recombinant COVID19 vaccine (Sf9 cells) (trivalent)","lang":"EN"}],"target":[[{"name":"SARS-CoV-2 S protein","lang":"EN"},{"name":"新冠病毒刺突蛋白","lang":"CN"}]],"disease":[[{"name":"COVID-19","lang":"EN"},{"name":"新型冠状病毒感染","lang":"CN"}]],"drug_type":["Prophylactic vaccine","Multivalent vaccine","Genetically engineered subunit vaccine"],"global_highest_dev_status":"Approved","first_approved_date":1686182400000,"first_approved_indication":[[{"name":"COVID-19","lang":"EN"},{"name":"新型冠状病毒感染","lang":"CN"}]],"approval_country":["China"]}
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{"drug_name":[{"name":"利妥昔单抗生物类似药（上海生物制品研究所）","lang":"CN"},{"name":"Rituximab biosimilar (Shanghai Institute of Biological Products)","lang":"EN"}],"alias":[{"name":"Recombinant chimeric anti-CD20 antibody(Shanghai Institute of Biological Products)","lang":"EN"},{"name":"重组人鼠嵌合抗CD20单克隆抗体 (上海生物制品研究所)","lang":"CN"}],"target":[[{"name":"B-lymphocyte antigen CD20","lang":"EN"},{"name":"B淋巴细胞抗原CD20","lang":"CN"}]],"disease":[[{"name":"CD20 positive Diffuse Large B-Cell Lymphoma","lang":"EN"},{"name":"CD20阳性弥漫性大B细胞淋巴瘤","lang":"CN"}],[{"name":"Chronic Lymphocytic Leukemia","lang":"EN"},{"name":"慢性淋巴细胞白血病","lang":"CN"}],[{"name":"Follicular Lymphoma","lang":"EN"},{"name":"滤泡性淋巴瘤","lang":"CN"}],[{"name":"CD20 Positive B-Cell Non-Hodgkin Lymphoma","lang":"EN"},{"name":"CD20阳性的B细胞非霍奇金淋巴瘤","lang":"CN"}]],"drug_type":["Biosimilar","Monoclonal antibody"],"global_highest_dev_status":"Approved","first_approved_date":1710806400000,"first_approved_indication":[[{"name":"CD20 positive Diffuse Large B-Cell Lymphoma","lang":"EN"},{"name":"CD20阳性弥漫性大B细胞淋巴瘤","lang":"CN"}],[{"name":"Chronic Lymphocytic Leukemia","lang":"EN"},{"name":"慢性淋巴细胞白血病","lang":"CN"}],[{"name":"Follicular Lymphoma","lang":"EN"},{"name":"滤泡性淋巴瘤","lang":"CN"}]],"approval_country":["China"]}
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{"drug_name":[{"name":"维泊妥珠单抗","lang":"CN"},{"name":"Polatuzumab Vedotin-Piiq","lang":"EN"},{"name":"ポラツズマブ ベドチン（遺伝子組換え）","lang":"JP"}],"alias":[{"name":"Polatuzumab Vedotin(Genetical Recombination)","lang":"EN"},{"name":"anti-CD79b-VC-MMAE","lang":"EN"},{"name":"polatuzumab vedotin","lang":"EN"},{"name":"polatuzumab vedotin-piic","lang":"EN"},{"name":"泊洛妥珠单抗","lang":"CN"},{"name":"泊洛妥珠单抗维多汀","lang":"CN"},{"name":"维博妥珠单抗","lang":"CN"}],"target":[[{"name":"B-cell antigen receptor complex-associated protein beta chain","lang":"EN"},{"name":"B细胞抗原受体复合物相关蛋白β链","lang":"CN"}],[{"name":"Tubulin","lang":"EN"},{"name":"微管蛋白","lang":"CN"}]],"disease":[[{"name":"Large B-cell lymphoma","lang":"EN"},{"name":"大B细胞淋巴瘤","lang":"CN"}],[{"name":"High grade B-cell lymphoma","lang":"EN"},{"name":"高级别B细胞淋巴瘤","lang":"CN"}],[{"name":"Diffuse large B-cell lymphoma refractory","lang":"EN"},{"name":"难治性弥漫性大 B 细胞淋巴瘤","lang":"CN"}],[{"name":"Refractory Lymphoma","lang":"EN"},{"name":"难治性淋巴瘤","lang":"CN"}],[{"name":"Diffuse large B-cell lymphoma recurrent","lang":"EN"},{"name":"复发性弥漫性大B细胞淋巴瘤","lang":"CN"}],[{"name":"Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell Type","lang":"EN"},{"name":"难治性弥漫性大B细胞淋巴瘤活化B细胞型","lang":"CN"}],[{"name":"Diffuse Large B-Cell Lymphoma","lang":"EN"},{"name":"弥漫性大B细胞淋巴瘤","lang":"CN"}],[{"name":"B-cell lymphoma refractory","lang":"EN"},{"name":"难治性B细胞淋巴瘤","lang":"CN"}],[{"name":"Mediastinal large B-cell lymphoma","lang":"EN"},{"name":"纵隔大b细胞淋巴瘤","lang":"CN"}],[{"name":"ALK positive large B-cell lymphoma","lang":"EN"},{"name":"ALK阳性大B细胞淋巴瘤","lang":"CN"}],[{"name":"T-cell/histiocyte rich large B-cell lymphoma","lang":"EN"},{"name":"T细胞/组织细胞丰富的大B细胞淋巴瘤","lang":"CN"}],[{"name":"CD20 positive Diffuse Large B-Cell Lymphoma","lang":"EN"},{"name":"CD20阳性弥漫性大B细胞淋巴瘤","lang":"CN"}],[{"name":"High grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements","lang":"EN"},{"name":"高级别B细胞淋巴瘤伴 MYC 和 BCL2 和/或 BCL6 重排","lang":"CN"}],[{"name":"CD20 positive Large B-cell lymphoma","lang":"EN"},{"name":"CD20阳性大B细胞淋巴瘤","lang":"CN"}],[{"name":"Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma","lang":"EN"},{"name":"复发性转化滤泡性淋巴瘤至弥漫性大 B 细胞淋巴瘤","lang":"CN"}],[{"name":"Non-Hodgkin's lymphoma refractory","lang":"EN"},{"name":"难治性非霍奇金淋巴瘤","lang":"CN"}],[{"name":"Recurrent Non-Hodgkin Lymphoma","lang":"EN"},{"name":"复发性非霍奇金淋巴瘤","lang":"CN"}],[{"name":"Refractory Aggressive Non-Hodgkin Lymphoma","lang":"EN"},{"name":"难治性侵袭性非霍奇金淋巴瘤","lang":"CN"}],[{"name":"Follicular Lymphoma","lang":"EN"},{"name":"滤泡性淋巴瘤","lang":"CN"}],[{"name":"Indolent B-Cell Non-Hodgkin Lymphoma","lang":"EN"},{"name":"惰性B细胞非霍奇金淋巴瘤","lang":"CN"}],[{"name":"Marginal Zone B-Cell Lymphoma","lang":"EN"},{"name":"边缘区B细胞淋巴瘤","lang":"CN"}],[{"name":"Richter's syndrome","lang":"EN"},{"name":"里氏综合症","lang":"CN"}],[{"name":"Porphyria Cutanea Tarda","lang":"EN"},{"name":"迟发性皮肤卟啉病","lang":"CN"}],[{"name":"Mantle-Cell Lymphoma","lang":"EN"},{"name":"套细胞淋巴瘤","lang":"CN"}],[{"name":"Non-Hodgkin Lymphoma","lang":"EN"},{"name":"非霍奇金淋巴瘤","lang":"CN"}],[{"name":"Refractory Follicular Lymphoma","lang":"EN"},{"name":"难治性滤泡性淋巴瘤","lang":"CN"}],[{"name":"Aggressive B-Cell Non-Hodgkin Lymphoma","lang":"EN"},{"name":"侵袭性 B 细胞非霍奇金淋巴瘤","lang":"CN"}],[{"name":"Aggressive Non-Hodgkin Lymphoma","lang":"EN"},{"name":"侵袭性非霍奇金淋巴瘤","lang":"CN"}],[{"name":"Epstein-Barr virus associated Diffuse Large B-Cell Lymphoma","lang":"EN"},{"name":"爱泼斯坦-巴尔病毒相关弥漫性大B细胞淋巴瘤","lang":"CN"}],[{"name":"Gray Zone Lymphoma","lang":"EN"},{"name":"灰区淋巴瘤","lang":"CN"}],[{"name":"Refractory Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma","lang":"EN"},{"name":"难治性转化滤泡性淋巴瘤至弥漫性大 B 细胞淋巴瘤","lang":"CN"}]],"drug_type":["Antibody drug conjugate (ADC)"],"global_highest_dev_status":"Phase 1/2 Clinical","first_approved_date":1560124800000,"first_approved_indication":[[{"name":"Diffuse Large B-Cell Lymphoma","lang":"EN"},{"name":"弥漫性大B细胞淋巴瘤","lang":"CN"}]],"approval_country":["United States","China","European Union","Japan","United Kingdom","Canada","Australia","Iceland","South Korea","Liechtenstein","Norway","Taiwan Province"]}
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{"drug_name":[{"name":"Fosdenopterin Hydrobromide","lang":"EN"}],"alias":[{"name":"cPMP","lang":"EN"},{"name":"cPMP-cpd","lang":"EN"}],"target":[[{"name":"Molybdenum cofactor","lang":"EN"},{"name":"钼辅因子","lang":"CN"}]],"disease":[[{"name":"Molybdenum Cofactor Deficiency","lang":"EN"},{"name":"钼辅酶缺乏症","lang":"CN"}],[{"name":"Molybdenum Cofactor Deficiency, Complementation Group A","lang":"EN"},{"name":"钼辅因子缺乏症A型","lang":"CN"}],[{"name":"Autosomal Recessive Disorder","lang":"EN"},{"name":"常染色体隐性遗传病","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Approved","first_approved_date":1614297600000,"first_approved_indication":[[{"name":"Molybdenum Cofactor Deficiency, Complementation Group A","lang":"EN"},{"name":"钼辅因子缺乏症A型","lang":"CN"}]],"approval_country":["United States","European Union","United Kingdom","Israel","Iceland","Liechtenstein","Norway"]}
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{"drug_name":[{"name":"泽诺库珠单抗","lang":"CN"},{"name":"Zenocutuzumab-zbco","lang":"EN"}],"alias":[{"name":"HER3 x HER2 Biclonics","lang":"EN"},{"name":"Immunoglobulin g1, bispecific, anti-(human epidermal growth factor receptors, her2 and her3) (humanized clone mcla-128 .gamma.1-chain), disulfide with humanized clone mcla-128 light chain, dimer","lang":"EN"},{"name":"Mcla-128 (igg1 bispecific antibody with enhanced antibody-dependent cell-mediated cytotoxicity (adcc) activity targeting her2 and her3 receptors.)","lang":"EN"},{"name":"Zeno","lang":"EN"},{"name":"Zenocutuzomab","lang":"EN"},{"name":"Zenocutuzumab","lang":"EN"},{"name":"Zenocutuzumab (USAN/INN)","lang":"EN"},{"name":"泽妥珠单抗","lang":"CN"}],"target":[[{"name":"Receptor tyrosine-protein kinase erbB-2","lang":"EN"},{"name":"受体蛋白酪氨酸激酶 erbB-2","lang":"CN"}],[{"name":"Receptor tyrosine-protein kinase erbB-3","lang":"EN"},{"name":"受体酪氨酸蛋白激酶erbB-3","lang":"CN"}]],"disease":[[{"name":"Adenocarcinoma of pancreas with NRG1 fusion","lang":"EN"},{"name":"NRG1 融合的胰腺腺癌","lang":"CN"}],[{"name":"NRG1 Fusion Positive non-small cell lung cancer","lang":"EN"},{"name":"NRG1融合阳性非小细胞肺癌","lang":"CN"}],[{"name":"Carcinoma bile duct non-resectable","lang":"EN"},{"name":"不能切除的胆管癌","lang":"CN"}],[{"name":"Metastatic Cholangiocarcinoma","lang":"EN"},{"name":"转移性胆管癌","lang":"CN"}],[{"name":"NRG1 Fusion Positive Solid Tumors","lang":"EN"},{"name":"NRG1融合阳性实体瘤","lang":"CN"}],[{"name":"ER Positive/HER2 Low Breast Cancer","lang":"EN"},{"name":"ER阳性HER2低表达乳腺癌","lang":"CN"}],[{"name":"Metastatic castration-resistant prostate cancer","lang":"EN"},{"name":"转移性去势抵抗性前列腺癌","lang":"CN"}],[{"name":"Metastatic human epidermal growth factor 2 positive carcinoma of breast","lang":"EN"},{"name":"HER2阳性转移性乳腺癌","lang":"CN"}]],"drug_type":["Bispecific antibody"],"global_highest_dev_status":"Approved","first_approved_date":1733270400000,"first_approved_indication":[[{"name":"Adenocarcinoma of pancreas with NRG1 fusion","lang":"EN"},{"name":"NRG1 融合的胰腺腺癌","lang":"CN"}],[{"name":"NRG1 Fusion Positive non-small cell lung cancer","lang":"EN"},{"name":"NRG1融合阳性非小细胞肺癌","lang":"CN"}]],"approval_country":["United States"]}
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{"drug_name":[{"name":"颠茄总生物碱/马来酸氯苯那敏/盐酸DL-甲基麻黄碱","lang":"CN"},{"name":"Belladonna Total Alkaloid/Chlorpheniramine Maleate/DL-Methylephedrine Hydrochloride","lang":"EN"}],"target":[[{"name":"Adrenergic receptors","lang":"EN"},{"name":"肾上腺素能受体家族","lang":"CN"}],[{"name":"Histamine H1 receptor","lang":"EN"},{"name":"组胺H1受体","lang":"CN"}]],"disease":[[{"name":"Common Cold","lang":"EN"},{"name":"普通感冒","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Approved","first_approved_date":1700006400000,"first_approved_indication":[[{"name":"Common Cold","lang":"EN"},{"name":"普通感冒","lang":"CN"}]],"approval_country":["South Korea"]}
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{"drug_name":[{"name":"帕瑞昔布钠","lang":"CN"},{"name":"Parecoxib Sodium","lang":"EN"}],"alias":[{"name":"N-((p-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propionamide","lang":"EN"},{"name":"Parecoxib sodium (USAN)","lang":"EN"},{"name":"Rayzon","lang":"EN"},{"name":"Xapit","lang":"EN"},{"name":"parecoxib","lang":"EN"}],"target":[[{"name":"Cyclooxygenase-2","lang":"EN"},{"name":"环氧化酶-2","lang":"CN"}]],"disease":[[{"name":"Pain, Postoperative","lang":"EN"},{"name":"术后疼痛","lang":"CN"}],[{"name":"Colic","lang":"EN"},{"name":"绞痛","lang":"CN"}],[{"name":"Renal Colic","lang":"EN"},{"name":"肾绞痛","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Discontinued","first_approved_date":1016755200000,"first_approved_indication":[[{"name":"Pain, Postoperative","lang":"EN"},{"name":"术后疼痛","lang":"CN"}]],"approval_country":["China","European Union","Australia","Iceland","Liechtenstein","Norway"]}
{"drug_name":[{"name":"盐酸马尼地平","lang":"CN"},{"name":"Manidipine Hydrochloride","lang":"EN"},{"name":"マニジピン塩酸塩","lang":"JP"}],"alias":[{"name":"Artedil","lang":"EN"},{"name":"Calslot","lang":"EN"},{"name":"Iperten","lang":"EN"},{"name":"Manidipine","lang":"EN"},{"name":"Manidipine dihydrochloride","lang":"EN"},{"name":"Manivasc","lang":"EN"},{"name":"Manyper","lang":"EN"},{"name":"franidipine","lang":"EN"}],"target":[[{"name":"calcium voltage-gated channel subunit alpha1 A","lang":"EN"}]],"disease":[[{"name":"Essential Hypertension","lang":"EN"},{"name":"原发性高血压","lang":"CN"}],[{"name":"Hypertension","lang":"EN"},{"name":"高血压","lang":"CN"}],[{"name":"Rheumatoid Arthritis","lang":"EN"},{"name":"类风湿关节炎","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Preclinical","first_approved_date":960508800000,"first_approved_indication":[[{"name":"Hypertension","lang":"EN"},{"name":"高血压","lang":"CN"}]],"approval_country":["China","Japan","Germany","Spain","France","Greece","Italy"]}
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{"drug_name":[{"name":"恩塞芬汀","lang":"CN"},{"name":"Ensifentrine","lang":"EN"}],"alias":[{"name":"Ensifentrine (USAN/INN)","lang":"EN"},{"name":"恩司芬群","lang":"CN"},{"name":"恩替芬特林","lang":"CN"}],"target":[[{"name":"Phosphodiesterase 3","lang":"EN"},{"name":"磷酸二酯酶3","lang":"CN"}],[{"name":"Phosphodieterase 4","lang":"EN"},{"name":"磷酸二酯酶4","lang":"CN"}]],"disease":[[{"name":"Pulmonary Disease, Chronic Obstructive","lang":"EN"},{"name":"慢性阻塞性肺疾病","lang":"CN"}],[{"name":"Non-cystic fibrosis bronchiectasis","lang":"EN"},{"name":"非囊性支气管扩张","lang":"CN"}],[{"name":"Asthma","lang":"EN"},{"name":"哮喘","lang":"CN"}],[{"name":"Cystic Fibrosis","lang":"EN"},{"name":"囊性纤维化","lang":"CN"}],[{"name":"Asthma chronic","lang":"EN"},{"name":"慢性哮喘","lang":"CN"}],[{"name":"COVID-19","lang":"EN"},{"name":"新型冠状病毒感染","lang":"CN"}],[{"name":"Inflammation","lang":"EN"},{"name":"炎症","lang":"CN"}],[{"name":"Moderate chronic obstructive pulmonary disease","lang":"EN"},{"name":"中度慢性阻塞性肺疾病","lang":"CN"}],[{"name":"Rhinitis, Allergic","lang":"EN"},{"name":"过敏性鼻炎","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Phase 2 Clinical","first_approved_date":1719360000000,"first_approved_indication":[[{"name":"Pulmonary Disease, Chronic Obstructive","lang":"EN"},{"name":"慢性阻塞性肺疾病","lang":"CN"}]],"approval_country":["United States","Macao"]}
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{"drug_name":[{"name":"拓培非格司亭","lang":"CN"},{"name":"Telpegfilgrastim","lang":"EN"}],"alias":[{"name":"Y-branched pegylated recombinant human granulocyte colony stimulating factor","lang":"EN"},{"name":"Y-shaped branched pegylated filgrastim","lang":"EN"},{"name":"YPEG-G-CSF","lang":"EN"},{"name":"YPEG-filgrastim","lang":"EN"},{"name":"YPEG-rhG-CSF","lang":"EN"},{"name":"Y型PEG 化重组人粒细胞刺激因子（厦门特宝）","lang":"CN"},{"name":"Y型聚乙二醇重组人粒细胞刺激因子","lang":"CN"}],"target":[[{"name":"Colony stimulating factor 3 receptor","lang":"EN"},{"name":"巨噬细胞集落刺激因子3受体","lang":"CN"}]],"disease":[[{"name":"Neutropenia","lang":"EN"},{"name":"中性粒细胞减少","lang":"CN"}],[{"name":"Pre-Eclampsia","lang":"EN"},{"name":"先兆子痫","lang":"CN"}],[{"name":"Eclampsia","lang":"EN"},{"name":"子痫","lang":"CN"}],[{"name":"Febrile Neutropenia","lang":"EN"},{"name":"粒细胞减少性发热","lang":"CN"}]],"drug_type":["Colony-stimulating factors"],"global_highest_dev_status":"Approved","first_approved_date":1688083200000,"first_approved_indication":[[{"name":"Neutropenia","lang":"EN"},{"name":"中性粒细胞减少","lang":"CN"}]],"approval_country":["China"]}
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{"drug_name":[{"name":"Neltependocel","lang":"EN"},{"name":"ネルテペンドセル","lang":"JP"}],"alias":[{"name":"Human corneal endothelial cell therapy(Aurion Biotech)","lang":"EN"},{"name":"培養ヒト角膜内皮細胞","lang":"JP"}],"target":[[{"name":"Rho-associated kinases","lang":"EN"},{"name":"Rho-相关激酶","lang":"CN"}]],"disease":[[{"name":"Bullous keratopathy","lang":"EN"},{"name":"大疱性角膜病变","lang":"CN"}],[{"name":"Corneal Edema","lang":"EN"},{"name":"角膜水肿","lang":"CN"}],[{"name":"Endothelial dysfunction","lang":"EN"},{"name":"内皮功能障碍","lang":"CN"}],[{"name":"Fuchs' Endothelial Dystrophy","lang":"EN"},{"name":"Fuchs内皮营养不良","lang":"CN"}]],"drug_type":["Cell therapy"],"global_highest_dev_status":"Approved","first_approved_date":1679011200000,"first_approved_indication":[[{"name":"Bullous keratopathy","lang":"EN"},{"name":"大疱性角膜病变","lang":"CN"}]],"approval_country":["Japan"]}
{"drug_name":[{"name":"蔗糖铁","lang":"CN"},{"name":"Iron sucrose","lang":"EN"},{"name":"スクロオキシ水酸化鉄","lang":"JP"}],"alias":[{"name":"Ferric hydroxide sucrose complex","lang":"EN"},{"name":"Ferric oxide, saccharated","lang":"EN"},{"name":"Ferric oxyhydroxide","lang":"EN"},{"name":"Ferrihydrite","lang":"EN"},{"name":"Iron oxide saccharated","lang":"EN"},{"name":"Iron oxyhydroxide","lang":"EN"},{"name":"Iron saccharate","lang":"EN"},{"name":"Iron sucrose (USP)","lang":"EN"},{"name":"Iron sucrose complex","lang":"EN"},{"name":"Iron sugar","lang":"EN"},{"name":"Iron(III) hydroxide sucrose complex","lang":"EN"},{"name":"Phosphate binder - Vifor Pharma","lang":"EN"},{"name":"Saccharated ferric oxide","lang":"EN"},{"name":"Saccharated iron","lang":"EN"},{"name":"Saccharated iron oxide","lang":"EN"},{"name":"Sucroferric oxyhydroxide","lang":"EN"},{"name":"mixture of polynuclear iron(III)-oxyhydroxide, sucrose and starches","lang":"EN"},{"name":"スクロオキシ水酸化鉄","lang":"JP"},{"name":"含糖酸化鉄","lang":"CN"},{"name":"蔗糖氢氧化氧铁","lang":"CN"},{"name":"蔗糖羟基氧化铁","lang":"CN"}],"target":[[{"name":"Phosphates","lang":"EN"},{"name":"磷酸盐","lang":"CN"}]],"disease":[[{"name":"Kidney Failure, Chronic","lang":"EN"},{"name":"终末期肾脏病","lang":"CN"}],[{"name":"Hyperphosphatemia","lang":"EN"},{"name":"高磷血症","lang":"CN"}],[{"name":"Iron deficiency","lang":"EN"},{"name":"铁缺乏","lang":"CN"}],[{"name":"Chronic Kidney Diseases","lang":"EN"},{"name":"慢性肾病","lang":"CN"}],[{"name":"Anemia, Iron-Deficiency","lang":"EN"},{"name":"缺铁性贫血","lang":"CN"}],[{"name":"Inflammatory Bowel Diseases","lang":"EN"},{"name":"炎症性肠病","lang":"CN"}],[{"name":"Neoplasms","lang":"EN"},{"name":"肿瘤","lang":"CN"}],[{"name":"Proteinuria","lang":"EN"},{"name":"蛋白尿","lang":"CN"}]],"drug_type":["Polymer"],"global_highest_dev_status":"Pending","first_approved_date":-649555200000,"first_approved_indication":[[{"name":"Anemia, Iron-Deficiency","lang":"EN"},{"name":"缺铁性贫血","lang":"CN"}]],"approval_country":["United States","China","European Union","Japan","United Kingdom","Canada","Australia","Switzerland","Iceland","Liechtenstein","Norway"]}
{"drug_name":[{"name":"盐酸佐利替尼","lang":"CN"},{"name":"Zorifertinib","lang":"EN"}],"alias":[{"name":"佐利替尼","lang":"CN"}],"target":[[{"name":"EGFR exon 21 L858R mutation","lang":"EN"},{"name":"EGFR21外显子L858R突变","lang":"CN"}],[{"name":"EGFR exon 19 deletion","lang":"EN"},{"name":"EGFR19外显子缺失突变","lang":"CN"}]],"disease":[[{"name":"EGFR exon 19 Deletions Mutant Non-small Cell Lung Cancer","lang":"EN"},{"name":"EGFR 外显子 19 缺失突变型非小细胞肺癌","lang":"CN"}],[{"name":"EGFR exon 21 Substitution Mutant Non-small Cell Lung Cancer","lang":"EN"},{"name":"EGFR外显子21替代突变非小细胞肺癌","lang":"CN"}],[{"name":"Metastatic Malignant Neoplasm to the Leptomeninges","lang":"EN"},{"name":"软脑膜转移性恶性肿瘤","lang":"CN"}],[{"name":"Advanced Lung Non-Small Cell Carcinoma","lang":"EN"},{"name":"晚期非小细胞肺癌","lang":"CN"}],[{"name":"EGFR-mutated non-small Cell Lung Cancer","lang":"EN"},{"name":"EGFR突变的非小细胞肺癌","lang":"CN"}],[{"name":"EGFR positive non-small cell lung cancer","lang":"EN"},{"name":"EGFR阳性非小细胞肺癌","lang":"CN"}],[{"name":"EGFR T790M Mutation Positive Non-Small Cell Lung Carcinoma","lang":"EN"},{"name":"EGFR-T790M 突变非小细胞肺癌","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Phase 2 Clinical","first_approved_date":1731628800000,"first_approved_indication":[[{"name":"EGFR exon 19 Deletions Mutant Non-small Cell Lung Cancer","lang":"EN"},{"name":"EGFR 外显子 19 缺失突变型非小细胞肺癌","lang":"CN"}],[{"name":"EGFR exon 21 Substitution Mutant Non-small Cell Lung Cancer","lang":"EN"},{"name":"EGFR外显子21替代突变非小细胞肺癌","lang":"CN"}]],"approval_country":["China"]}
{"drug_name":[{"name":"Betibeglogene autotemcel","lang":"EN"}],"alias":[{"name":"2009 EGT-produced vector","lang":"EN"},{"name":"Autologous CD34+ cell enriched population that contains hematopoietic stem cells transduced with lentiglobin BB305 lentiviral vector encoding the beta-A-T87Q-globin gene","lang":"EN"},{"name":"Autologous CD34+ cells encoding βA-T87Q-globin gene","lang":"EN"},{"name":"Autologous CD34+ cells transduced with TNS9.3.55","lang":"EN"},{"name":"Autologous CD34+ stem cells","lang":"EN"},{"name":"Beta globin transduced bone marrow cells","lang":"EN"},{"name":"Lentiglobin","lang":"EN"},{"name":"TNS9-3-55 transduced CD34 cells","lang":"EN"},{"name":"Thalagen","lang":"EN"},{"name":"Thalassaemia gene therapy","lang":"EN"},{"name":"betibeglogene darolentivec","lang":"EN"}],"target":[[{"name":"Hemoglobin beta chain","lang":"EN"},{"name":"血红蛋白β链","lang":"CN"}]],"disease":[[{"name":"Thalassemia","lang":"EN"},{"name":"地中海贫血","lang":"CN"}],[{"name":"Beta-Thalassemia","lang":"EN"},{"name":"β地中海贫血","lang":"CN"}],[{"name":"Anemia, Sickle Cell","lang":"EN"},{"name":"镰状细胞血症","lang":"CN"}],[{"name":"Transfusion-dependent Beta Thalassemia","lang":"EN"},{"name":"输血依赖性β地中海贫血","lang":"CN"}],[{"name":"Transfusion-dependent Thalassemia","lang":"EN"},{"name":"输血依赖性地中海贫血","lang":"CN"}]],"drug_type":["Gene therapy","Hematopoietic stem cell therapy"],"global_highest_dev_status":"Approved","first_approved_date":1559088000000,"first_approved_indication":[[{"name":"Transfusion-dependent Beta Thalassemia","lang":"EN"},{"name":"输血依赖性β地中海贫血","lang":"CN"}]],"approval_country":["United States","United Kingdom"]}
{"drug_name":[{"name":"甲氧沙林","lang":"CN"},{"name":"Methoxsalen","lang":"EN"},{"name":"メトキサレン","lang":"JP"}],"alias":[{"name":"6-hydroxy-7-methoxy-5-benzofuranacrylic acid δ-lactone","lang":"EN"},{"name":"8-MP","lang":"EN"},{"name":"8-Methoxyfuranocoumarin","lang":"EN"},{"name":"8-methoxy-2',3',6,7-furocoumarin","lang":"EN"},{"name":"8-methoxy-4',5':6,7-furocoumarin","lang":"EN"},{"name":"8-methoxy-[furano-3'.2':6.7-coumarin]","lang":"EN"},{"name":"8-methoxypsoralen","lang":"EN"},{"name":"9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one","lang":"EN"},{"name":"Ammoidin","lang":"EN"},{"name":"Methoxsalen (JP17/USP)","lang":"EN"},{"name":"Methoxsalen solution","lang":"EN"},{"name":"Methoxsalen sterile solution - Therakos","lang":"EN"},{"name":"O-methylxanthotoxol","lang":"EN"},{"name":"Xanthotoxin","lang":"EN"},{"name":"Xanthotoxine","lang":"EN"}],"target":[[{"name":"DNA","lang":"EN"},{"name":"DNA","lang":"CN"}]],"disease":[[{"name":"Graft vs Host Disease","lang":"EN"},{"name":"移植物抗宿主病","lang":"CN"}],[{"name":"Cutaneous T-Cell Lymphoma","lang":"EN"},{"name":"皮肤T细胞淋巴瘤","lang":"CN"}],[{"name":"Psoriasis","lang":"EN"},{"name":"银屑病","lang":"CN"}],[{"name":"Vitiligo","lang":"EN"},{"name":"白癜风","lang":"CN"}],[{"name":"Scleroderma, Diffuse","lang":"EN"},{"name":"弥漫性硬皮病","lang":"CN"}],[{"name":"Rheumatoid Arthritis","lang":"EN"},{"name":"类风湿关节炎","lang":"CN"}],[{"name":"Acute Graft Versus Host Disease","lang":"EN"},{"name":"急性移植物抗宿主病","lang":"CN"}],[{"name":"AIDS-Related Complex","lang":"EN"},{"name":"艾滋病相关复合征","lang":"CN"}],[{"name":"Chronic graft-versus-host disease","lang":"EN"},{"name":"慢性移植物抗宿主病","lang":"CN"}],[{"name":"Colitis","lang":"EN"},{"name":"结肠炎","lang":"CN"}],[{"name":"Crohn Disease","lang":"EN"},{"name":"克罗恩病","lang":"CN"}],[{"name":"Mycosis Fungoides","lang":"EN"},{"name":"蕈样真菌病","lang":"CN"}],[{"name":"Refractory Acute Graft Versus Host Disease","lang":"EN"},{"name":"难治性急性移植物抗宿主病","lang":"CN"}],[{"name":"Sezary Syndrome","lang":"EN"},{"name":"塞扎里综合征","lang":"CN"}],[{"name":"Steroid Refractory Graft Versus Host Disease","lang":"EN"},{"name":"类固醇难治性移植物抗宿主病","lang":"CN"}],[{"name":"Unresectable Melanoma","lang":"EN"},{"name":"不可切除的黑色素瘤","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Discontinued","first_approved_date":-475891200000,"first_approved_indication":[[{"name":"Cutaneous T-Cell Lymphoma","lang":"EN"},{"name":"皮肤T细胞淋巴瘤","lang":"CN"}],[{"name":"Psoriasis","lang":"EN"},{"name":"银屑病","lang":"CN"}],[{"name":"Vitiligo","lang":"EN"},{"name":"白癜风","lang":"CN"}]],"approval_country":["United States","China","Japan","Australia"]}
{"drug_name":[{"name":"司帕生坦","lang":"CN"},{"name":"Sparsentan","lang":"EN"}],"alias":[{"name":"Sparsentan (USAN/INN)","lang":"EN"}],"target":[[{"name":"Angiotensin II Receptor Type 1","lang":"EN"},{"name":"血管紧张素II-1型受体","lang":"CN"}],[{"name":"Endothelin receptor type A","lang":"EN"},{"name":"内皮素A受体","lang":"CN"}]],"disease":[[{"name":"Glomerulosclerosis, Focal Segmental","lang":"EN"},{"name":"局灶性节段性肾小球硬化症","lang":"CN"}],[{"name":"Glomerulonephritis, IGA","lang":"EN"},{"name":"免疫球蛋白a肾病","lang":"CN"}],[{"name":"Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis","lang":"EN"},{"name":"抗中性粒细胞胞质抗体相关性血管炎","lang":"CN"}],[{"name":"Kidney Diseases","lang":"EN"},{"name":"肾脏疾病","lang":"CN"}],[{"name":"Glomerular disease","lang":"EN"},{"name":"肾小球疾病","lang":"CN"}],[{"name":"Nephritis, Hereditary","lang":"EN"},{"name":"Alport 综合征","lang":"CN"}],[{"name":"Nephrosis, Lipoid","lang":"EN"},{"name":"微小病变性肾病","lang":"CN"}],[{"name":"Purpura, Schoenlein-Henoch","lang":"EN"},{"name":"过敏性紫癜","lang":"CN"}],[{"name":"Proteinuria","lang":"EN"},{"name":"蛋白尿","lang":"CN"}],[{"name":"Hypertension","lang":"EN"},{"name":"高血压","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Phase 2 Clinical","first_approved_date":1676592000000,"first_approved_indication":[[{"name":"Glomerulonephritis, IGA","lang":"EN"},{"name":"免疫球蛋白a肾病","lang":"CN"}]],"approval_country":["United States","European Union","United Kingdom","Switzerland","Iceland","Liechtenstein","Norway"]}
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{"drug_name":[{"name":"盐酸氨柔比星","lang":"CN"},{"name":"Amrubicin Hydrochloride","lang":"EN"},{"name":"アムルビシン塩酸塩","lang":"JP"}],"alias":[{"name":"AMR","lang":"EN"},{"name":"Amrubicin","lang":"EN"},{"name":"Amrubicin hydrochloride (JAN/USAN)","lang":"EN"}],"target":[[{"name":"DNA","lang":"EN"},{"name":"DNA","lang":"CN"}],[{"name":"Topoisomerase II","lang":"EN"},{"name":"拓扑异构酶II","lang":"CN"}]],"disease":[[{"name":"Non-Small Cell Lung Cancer","lang":"EN"},{"name":"非小细胞肺癌","lang":"CN"}],[{"name":"Small Cell Lung Cancer","lang":"EN"},{"name":"小细胞肺癌","lang":"CN"}],[{"name":"Advanced Malignant Solid Neoplasm","lang":"EN"},{"name":"晚期恶性实体瘤","lang":"CN"}],[{"name":"Bladder Cancer","lang":"EN"},{"name":"膀胱癌","lang":"CN"}],[{"name":"Extensive stage Small Cell Lung Cancer","lang":"EN"},{"name":"广泛期小细胞肺癌","lang":"CN"}],[{"name":"Metastatic breast cancer","lang":"EN"},{"name":"转移性乳腺癌","lang":"CN"}],[{"name":"Metastatic urothelial carcinoma","lang":"EN"},{"name":"转移性尿路上皮癌","lang":"CN"}],[{"name":"Refractory Multiple Myeloma","lang":"EN"},{"name":"难治性多发性骨髓瘤","lang":"CN"}],[{"name":"Relapse multiple myeloma","lang":"EN"},{"name":"复发性多发性骨髓瘤","lang":"CN"}],[{"name":"thymic carcinoma","lang":"EN"},{"name":"胸腺癌","lang":"CN"}],[{"name":"Thymoma, Familial","lang":"EN"},{"name":"家族性胸腺瘤","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Discontinued","first_approved_date":1018483200000,"first_approved_indication":[[{"name":"Non-Small Cell Lung Cancer","lang":"EN"},{"name":"非小细胞肺癌","lang":"CN"}],[{"name":"Small Cell Lung Cancer","lang":"EN"},{"name":"小细胞肺癌","lang":"CN"}]],"approval_country":["Japan"]}
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{"drug_name":[{"name":"右酮洛芬氨丁三醇/盐酸曲马多","lang":"CN"},{"name":"Dexketoprofen Trometamol/Tramadol Hydrochloride","lang":"EN"}],"alias":[{"name":"DKP.TRIS/TRAM","lang":"EN"},{"name":"DKP.TRIS/TRAM.HCL","lang":"EN"},{"name":"DKP/TRAM","lang":"EN"},{"name":"DKP/TRAM.HCL","lang":"EN"},{"name":"Dexketoprofen trometamol/tramadol","lang":"EN"},{"name":"Dexketoprofen/tramadol","lang":"EN"},{"name":"Dexketoprofen/tramadol hydrochloride","lang":"EN"},{"name":"Dexketoprofene/tramadolo","lang":"EN"},{"name":"Lenizak","lang":"EN"},{"name":"Skudex","lang":"EN"},{"name":"Skudexa","lang":"EN"},{"name":"Skudexum","lang":"EN"},{"name":"Skudo","lang":"EN"},{"name":"TRAM.H","lang":"EN"}],"target":[[{"name":"Cyclooxygenase-1","lang":"EN"},{"name":"环氧化酶-1","lang":"CN"}],[{"name":"Cyclooxygenase-2","lang":"EN"},{"name":"环氧化酶-2","lang":"CN"}],[{"name":"Mu opioid receptor","lang":"EN"},{"name":"μ-阿片受体","lang":"CN"}]],"disease":[[{"name":"Acute Pain","lang":"EN"},{"name":"急性疼痛","lang":"CN"}],[{"name":"Pain, Postoperative","lang":"EN"},{"name":"术后疼痛","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Pending","first_approved_date":1450569600000,"first_approved_indication":[[{"name":"Acute Pain","lang":"EN"},{"name":"急性疼痛","lang":"CN"}]],"approval_country":["United Kingdom","Austria","Belgium","Bulgaria","Cyprus","Czechia","Germany","Denmark","Estonia","Spain","Finland","France","Greece","Croatia","Hungary","Ireland","Italy","Lithuania","Luxembourg","Latvia","Malta","Netherlands","Poland","Portugal","Romania","Sweden","Slovenia","Slovakia"]}
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{"drug_name":[{"name":"对乙酰氨基酚/马来酸氯苯那敏/氢溴酸右美沙芬水合物/愈创甘油醚/盐酸那可汀水合物/丁酸核黄素/盐酸呋喃硫胺","lang":"CN"},{"name":"Acetaminophen/Chlorpheniramine Maleate/Dextromethorphan Hydrobromide Hydrate/Guaifenesin/Noscapine Hydrochloride Hydrate/Riboflavin Butyrate/Fursultiamine Hydrochloride","lang":"EN"}],"target":[[{"name":"Cyclooxygenases","lang":"EN"},{"name":"环氧化酶","lang":"CN"}],[{"name":"Histamine H1 receptor","lang":"EN"},{"name":"组胺H1受体","lang":"CN"}],[{"name":"Glutamate [NMDA] receptor","lang":"EN"},{"name":"谷氨酸[NMDA]受体复合体","lang":"CN"}],[{"name":"Sigma opioid receptor","lang":"EN"},{"name":"σ-阿片受体","lang":"CN"}]],"disease":[[{"name":"Common Cold","lang":"EN"},{"name":"普通感冒","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Approved","first_approved_date":1764892800000,"first_approved_indication":[[{"name":"Common Cold","lang":"EN"},{"name":"普通感冒","lang":"CN"}]],"approval_country":["South Korea"]}
{"drug_name":[{"name":"阿伐替尼","lang":"CN"},{"name":"Avapritinib","lang":"EN"}],"alias":[{"name":"Avapritinib (USAN/INN)","lang":"EN"},{"name":"阿泊替尼","lang":"CN"}],"target":[[{"name":"Platelet-derived growth factor receptor alpha","lang":"EN"},{"name":"血小板衍生生长因子受体α","lang":"CN"}],[{"name":"Stem cell growth factor receptor","lang":"EN"},{"name":"干细胞生长因子受体","lang":"CN"}]],"disease":[[{"name":"Gastrointestinal Stromal Tumors","lang":"EN"},{"name":"胃肠道间质瘤","lang":"CN"}],[{"name":"Indolent systemic mastocytosis","lang":"EN"},{"name":"髓性系统性肥大细胞增多症","lang":"CN"}],[{"name":"Aggressive Systemic Mastocytosis","lang":"EN"},{"name":"侵袭性系统性肥大细胞增多症","lang":"CN"}],[{"name":"Mast-Cell Leukemia","lang":"EN"},{"name":"肥大细胞白血病","lang":"CN"}],[{"name":"Metastatic Gastrointestinal Stromal Tumor","lang":"EN"},{"name":"转移性胃肠道间质瘤","lang":"CN"}],[{"name":"Unresectable Gastrointestinal Stromal Tumor","lang":"EN"},{"name":"不可切除的胃肠道间质瘤","lang":"CN"}],[{"name":"Systemic Mastocytosis","lang":"EN"},{"name":"系统性肥大细胞增多症","lang":"CN"}],[{"name":"PDGFRA D842V mutation Gastrointestinal Stromal Tumors","lang":"EN"},{"name":"PDGFRA D842V突变胃肠道间质瘤","lang":"CN"}],[{"name":"PDGFRA Exon 18 Mutation-Positive Gastrointestinal Stromal Tumor","lang":"EN"},{"name":"PDGFRA 外显子 18 突变阳性胃肠道间质瘤","lang":"CN"}],[{"name":"Central Nervous System Neoplasms","lang":"EN"},{"name":"中枢神经系统肿瘤","lang":"CN"}],[{"name":"Relapsed Solid Neoplasm","lang":"EN"},{"name":"复发性实体肿瘤","lang":"CN"}],[{"name":"Advanced Malignant Solid Neoplasm","lang":"EN"},{"name":"晚期恶性实体瘤","lang":"CN"}],[{"name":"Astrocytoma, IDH-Mutant","lang":"EN"},{"name":"IDH突变星形细胞瘤","lang":"CN"}],[{"name":"Diffuse Midline Glioma","lang":"EN"},{"name":"弥漫性中线胶质瘤","lang":"CN"}],[{"name":"Glioblastoma","lang":"EN"},{"name":"胶质母细胞瘤","lang":"CN"}],[{"name":"Glioma","lang":"EN"},{"name":"胶质瘤","lang":"CN"}],[{"name":"IDH-mutant oligodendroglioma","lang":"EN"},{"name":"IDH 突变型少突胶质细胞瘤","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Approved","first_approved_date":1578528000000,"first_approved_indication":[[{"name":"PDGFRA Exon 18 Mutation-Positive Gastrointestinal Stromal Tumor","lang":"EN"},{"name":"PDGFRA 外显子 18 突变阳性胃肠道间质瘤","lang":"CN"}]],"approval_country":["United States","China","European Union","United Kingdom","Canada","Hong Kong","Iceland","Liechtenstein","Norway","Taiwan Province"]}
{"drug_name":[{"name":"甲磺酸伏美替尼","lang":"CN"},{"name":"Alflutinib Mesylate","lang":"EN"}],"alias":[{"name":"Alflutinib","lang":"EN"},{"name":"Firmonertinib","lang":"EN"},{"name":"Firmonertinib Mesilate","lang":"EN"},{"name":"Furmonertinib","lang":"EN"},{"name":"Furmonertinib Mesilate","lang":"EN"},{"name":"Furmonertinib mesylate","lang":"EN"},{"name":"Iflutinib mesylate","lang":"EN"},{"name":"Ivesa","lang":"EN"},{"name":"Vometinib mesylate","lang":"EN"},{"name":"甲磺酸艾氟替尼","lang":"CN"}],"target":[[{"name":"EGFR exon 21 L858R mutation","lang":"EN"},{"name":"EGFR21外显子L858R突变","lang":"CN"}],[{"name":"Epidermal Growth Factor Receptor T790M","lang":"EN"},{"name":"表皮生长因子受体T790M","lang":"CN"}],[{"name":"EGFR exon 20 Mutation","lang":"EN"},{"name":"EGFR exon 20突变","lang":"CN"}],[{"name":"EGFR exon 19 deletion","lang":"EN"},{"name":"EGFR19外显子缺失突变","lang":"CN"}]],"disease":[[{"name":"EGFR ex20ins mutation in non-small cell lung cancer","lang":"EN"},{"name":"EGFR 20号外显子插入突变非小细胞肺癌","lang":"CN"}],[{"name":"EGFR exon 19 Deletions Mutant Non-small Cell Lung Cancer","lang":"EN"},{"name":"EGFR 外显子 19 缺失突变型非小细胞肺癌","lang":"CN"}],[{"name":"EGFR exon 21 Substitution Mutant Non-small Cell Lung Cancer","lang":"EN"},{"name":"EGFR外显子21替代突变非小细胞肺癌","lang":"CN"}],[{"name":"EGFR T790M Mutation Positive Non-Small Cell Lung Carcinoma","lang":"EN"},{"name":"EGFR-T790M 突变非小细胞肺癌","lang":"CN"}],[{"name":"Advanced Lung Non-Small Cell Carcinoma","lang":"EN"},{"name":"晚期非小细胞肺癌","lang":"CN"}],[{"name":"EGFR mutation Solid Tumors","lang":"EN"},{"name":"EGFR 突变实体瘤","lang":"CN"}],[{"name":"Non-small cell lung cancer stage IIIB","lang":"EN"},{"name":"非小细胞肺癌IIIB期","lang":"CN"}],[{"name":"EGFR positive Neoplasms","lang":"EN"},{"name":"EGFR阳性肿瘤","lang":"CN"}],[{"name":"EGFR-mutated non-small Cell Lung Cancer","lang":"EN"},{"name":"EGFR突变的非小细胞肺癌","lang":"CN"}],[{"name":"EGFR positive Non-squamous non-small cell lung cancer","lang":"EN"},{"name":"EGFR阳性非鳞状非小细胞肺癌","lang":"CN"}],[{"name":"Lung Cancer with Brain Metastasis","lang":"EN"},{"name":"肺癌脑转移","lang":"CN"}],[{"name":"Non-squamous non-small cell lung cancer","lang":"EN"},{"name":"非鳞状非小细胞肺癌","lang":"CN"}],[{"name":"EGFR positive non-small cell lung cancer","lang":"EN"},{"name":"EGFR阳性非小细胞肺癌","lang":"CN"}],[{"name":"Locally Advanced Lung Non-Small Cell Carcinoma","lang":"EN"},{"name":"局部晚期非小细胞肺癌","lang":"CN"}],[{"name":"metastatic non-small cell lung cancer","lang":"EN"},{"name":"转移性非小细胞肺癌","lang":"CN"}],[{"name":"EGFR positive Adenocarcinoma of Lung","lang":"EN"},{"name":"EGFR阳性肺腺癌","lang":"CN"}],[{"name":"Adenocarcinoma of Lung","lang":"EN"},{"name":"肺腺癌","lang":"CN"}],[{"name":"EGFR Mutation Lung Cancer","lang":"EN"},{"name":"EGFR突变肺癌","lang":"CN"}],[{"name":"Malignant Pleural Effusion","lang":"EN"},{"name":"恶性胸腔积液","lang":"CN"}],[{"name":"HER2 mutant non-small cell lung cancer","lang":"EN"},{"name":"HER2突变型非小细胞肺癌","lang":"CN"}],[{"name":"Metastatic Non-Squamous Non-Small Cell Lung Carcinoma","lang":"EN"},{"name":"转移性非鳞状非小细胞肺癌","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Phase 3 Clinical","first_approved_date":1614729600000,"first_approved_indication":[[{"name":"EGFR T790M Mutation Positive Non-Small Cell Lung Carcinoma","lang":"EN"},{"name":"EGFR-T790M 突变非小细胞肺癌","lang":"CN"}]],"approval_country":["China"]}
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{"drug_name":[{"name":"Clostridium botulinum toxin type A(PharmaResearch BIO)","lang":"EN"}],"target":[[{"name":"Synaptosomal-associated protein 25","lang":"EN"},{"name":"突触相关蛋白25","lang":"CN"}]],"disease":[[{"name":"Glabellar frown lines","lang":"EN"},{"name":"眉间纹","lang":"CN"}]],"drug_type":["Toxin"],"global_highest_dev_status":"Approved","first_approved_date":1706745600000,"first_approved_indication":[[{"name":"Glabellar frown lines","lang":"EN"},{"name":"眉间纹","lang":"CN"}]],"approval_country":["South Korea"]}
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{"drug_name":[{"name":"比沙可啶/熊去氧胆酸/多库酯钠","lang":"CN"},{"name":"Bisacodyl/Ursodiol/Dioctyl Sodium Sulfosuccinate","lang":"EN"}],"alias":[{"name":"比沙可啶/熊去氧胆酸/二辛基磺化琥珀酸钠","lang":"CN"}],"target":[[{"name":"Bile acid receptor FXR","lang":"EN"},{"name":"胆汁酸受体FXR","lang":"CN"}]],"disease":[[{"name":"Constipation","lang":"EN"},{"name":"便秘","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Approved","first_approved_date":1724630400000,"first_approved_indication":[[{"name":"Constipation","lang":"EN"},{"name":"便秘","lang":"CN"}]],"approval_country":["South Korea"]}
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{"drug_name":[{"name":"FINLAY-FR2 anti-SARS-CoV-2 Vaccine(Finlay Vaccine Institute)","lang":"EN"}],"target":[[{"name":"SARS-CoV-2 S protein","lang":"EN"},{"name":"新冠病毒刺突蛋白","lang":"CN"}]],"disease":[[{"name":"COVID-19","lang":"EN"},{"name":"新型冠状病毒感染","lang":"CN"}]],"drug_type":["Prophylactic vaccine","Genetically engineered subunit vaccine"],"global_highest_dev_status":"Approved","first_approved_date":1633392000000,"first_approved_indication":[[{"name":"COVID-19","lang":"EN"},{"name":"新型冠状病毒感染","lang":"CN"}]],"approval_country":["Cuba","Iran","Nicaragua","Venezuela"]}
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{"drug_name":[{"name":"德谷门冬双胰岛素 (惠升生物)","lang":"CN"},{"name":"Insulin degludec/Insulin aspart (Huisheng Pharm)","lang":"EN"}],"alias":[{"name":"Insulin Degludec / Insulin Aspart Biosimilar (Jilin Huisheng Biological Pharmaceutical Co., Ltd.)","lang":"EN"},{"name":"德谷门冬双胰岛素生物类似药（Jilin Huisheng Biological Pharmaceutical Co., Ltd.）","lang":"CN"}],"target":[[{"name":"Insulin receptor","lang":"EN"},{"name":"胰岛素受体","lang":"CN"}]],"disease":[[{"name":"Diabetes Mellitus, Type 2","lang":"EN"},{"name":"2型糖尿病","lang":"CN"}]],"drug_type":["Biosimilar","Peptide Hormone"],"global_highest_dev_status":"Approved","first_approved_date":1722297600000,"first_approved_indication":[[{"name":"Diabetes Mellitus, Type 2","lang":"EN"},{"name":"2型糖尿病","lang":"CN"}]],"approval_country":["China"]}
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{"drug_name":[{"name":"Golodirsen","lang":"EN"}],"alias":[{"name":"Golodirsen (USAN/INN)","lang":"EN"}],"target":[[{"name":"Dystrophin exon 53","lang":"EN"},{"name":"DMD 外显子53","lang":"CN"}]],"disease":[[{"name":"Muscular Dystrophy, Duchenne","lang":"EN"},{"name":"杜氏肌营养不良症","lang":"CN"}]],"drug_type":["ASO"],"global_highest_dev_status":"Approved","first_approved_date":1576108800000,"first_approved_indication":[[{"name":"Muscular Dystrophy, Duchenne","lang":"EN"},{"name":"杜氏肌营养不良症","lang":"CN"}]],"approval_country":["United States"]}
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{"drug_name":[{"name":"埃索美拉唑锶/萘普生","lang":"CN"},{"name":"Esomeprazole Strontium/Naproxen","lang":"EN"}],"alias":[{"name":"Naproxen/esomeprazole SR","lang":"EN"}],"target":[[{"name":"Cyclooxygenases","lang":"EN"},{"name":"环氧化酶","lang":"CN"}],[{"name":"Proton pump","lang":"EN"},{"name":"质子泵","lang":"CN"}]],"disease":[[{"name":"Ankylosing Spondylitis","lang":"EN"},{"name":"强直性脊柱炎","lang":"CN"}],[{"name":"Osteoarthritis","lang":"EN"},{"name":"骨关节炎","lang":"CN"}],[{"name":"Rheumatoid Arthritis","lang":"EN"},{"name":"类风湿关节炎","lang":"CN"}],[{"name":"Low Back Pain","lang":"EN"},{"name":"腰痛","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Phase 3 Clinical","first_approved_date":1377043200000,"first_approved_indication":[[{"name":"Ankylosing Spondylitis","lang":"EN"},{"name":"强直性脊柱炎","lang":"CN"}],[{"name":"Osteoarthritis","lang":"EN"},{"name":"骨关节炎","lang":"CN"}],[{"name":"Rheumatoid Arthritis","lang":"EN"},{"name":"类风湿关节炎","lang":"CN"}]],"approval_country":["South Korea"]}
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{"drug_name":[{"name":"地舒单抗生物类似药 (山东博安生物)","lang":"CN"},{"name":"Denosumab Biosimilar (Boan Biological)","lang":"EN"}],"alias":[{"name":"Anti-RANKL monoclonal antibody (Boan Biological)","lang":"EN"},{"name":"Denosumab Biosimilar (Shandong Boan Biotechnology Co., Ltd.)","lang":"EN"},{"name":"地舒单抗生物类似药（山东博安生物技术股份有限公司）","lang":"CN"},{"name":"重组抗RANKL全人单克隆抗体 (博安生物)","lang":"CN"}],"target":[[{"name":"Tumor necrosis factor ligand superfamily member 11","lang":"EN"},{"name":"肿瘤坏死因子配体超家族成员11","lang":"CN"}]],"disease":[[{"name":"Giant Cell Tumor of Bone","lang":"EN"},{"name":"骨巨细胞瘤","lang":"CN"}],[{"name":"Osteoporosis, Postmenopausal","lang":"EN"},{"name":"绝经期后骨质疏松","lang":"CN"}],[{"name":"Advanced cancer","lang":"EN"},{"name":"晚期癌症","lang":"CN"}],[{"name":"Osteoporosis","lang":"EN"},{"name":"骨质疏松症","lang":"CN"}],[{"name":"Prostatic Cancer","lang":"EN"},{"name":"前列腺癌","lang":"CN"}],[{"name":"Fractures, Bone","lang":"EN"},{"name":"骨折","lang":"CN"}],[{"name":"Bone metastases","lang":"EN"},{"name":"骨转移癌","lang":"CN"}]],"drug_type":["Biosimilar","Monoclonal antibody"],"global_highest_dev_status":"Pending","first_approved_date":1667865600000,"first_approved_indication":[[{"name":"Osteoporosis, Postmenopausal","lang":"EN"},{"name":"绝经期后骨质疏松","lang":"CN"}]],"approval_country":["China","Bolivia","Macao"]}
{"drug_name":[{"name":"普拉曲沙","lang":"CN"},{"name":"Pralatrexate","lang":"EN"},{"name":"プララトレキサート","lang":"JP"}],"alias":[{"name":"(2S)-2-((4-((1RS)-1-((2,4-Diaminopteridin-6-yl)methyl)but-3-ynyl)benzoyl)amino)pentanedioic acid","lang":"EN"},{"name":"(2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid","lang":"EN"},{"name":"10-Propargyl-10-deazaaminopterin","lang":"EN"},{"name":"N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid","lang":"EN"},{"name":"PDX","lang":"EN"},{"name":"Pralatrexate (JAN/USAN/INN)","lang":"EN"}],"target":[[{"name":"Dihydrofolate reductase","lang":"EN"},{"name":"二氢叶酸还原酶","lang":"CN"}]],"disease":[[{"name":"Peripheral T-Cell Lymphoma","lang":"EN"},{"name":"外周T细胞淋巴瘤","lang":"CN"}],[{"name":"Peripheral T-cell lymphoma unspecified recurrent","lang":"EN"},{"name":"复发型外周T细胞淋巴瘤","lang":"CN"}],[{"name":"Peripheral T-cell lymphoma unspecified refractory","lang":"EN"},{"name":"难治性外周T细胞淋巴瘤","lang":"CN"}],[{"name":"Advanced Malignant Solid Neoplasm","lang":"EN"},{"name":"晚期恶性实体瘤","lang":"CN"}],[{"name":"Stomach Cancer","lang":"EN"},{"name":"胃癌","lang":"CN"}],[{"name":"Adenocarcinoma of Esophagus","lang":"EN"},{"name":"食管腺癌","lang":"CN"}],[{"name":"Advanced breast cancer","lang":"EN"},{"name":"晚期乳腺癌","lang":"CN"}],[{"name":"Advanced Lung Non-Small Cell Carcinoma","lang":"EN"},{"name":"晚期非小细胞肺癌","lang":"CN"}],[{"name":"ALK-positive anaplastic large cell lymphoma","lang":"EN"},{"name":"ALK阳性间变性大细胞淋巴瘤","lang":"CN"}],[{"name":"B-cell lymphoma refractory","lang":"EN"},{"name":"难治性B细胞淋巴瘤","lang":"CN"}],[{"name":"CD30-Positive recurrent or refractory Cutaneous T-Cell Lymphoma","lang":"EN"}],[{"name":"Cutaneous T-Cell Lymphoma","lang":"EN"},{"name":"皮肤T细胞淋巴瘤","lang":"CN"}],[{"name":"Esophageal Squamous Cell Carcinoma","lang":"EN"},{"name":"食管鳞状细胞癌","lang":"CN"}],[{"name":"Gastroesophageal junction adenocarcinoma","lang":"EN"},{"name":"胃食管交界处腺癌","lang":"CN"}],[{"name":"Hematologic Neoplasms","lang":"EN"},{"name":"血液肿瘤","lang":"CN"}],[{"name":"hepatosplenic T-cell lymphoma","lang":"EN"},{"name":"肝脾 T 细胞淋巴瘤","lang":"CN"}],[{"name":"Hodgkin's Lymphoma","lang":"EN"},{"name":"霍奇金淋巴瘤","lang":"CN"}],[{"name":"Immunoblastic Lymphadenopathy","lang":"EN"},{"name":"免疫母细胞性淋巴结病","lang":"CN"}],[{"name":"Malignant neoplasm of gastro-oesophageal junction","lang":"EN"},{"name":"胃食管交界处恶性肿瘤","lang":"CN"}],[{"name":"Metastatic breast cancer","lang":"EN"},{"name":"转移性乳腺癌","lang":"CN"}],[{"name":"Mucositis","lang":"EN"},{"name":"粘膜炎","lang":"CN"}],[{"name":"Mycosis Fungoides","lang":"EN"},{"name":"蕈样真菌病","lang":"CN"}],[{"name":"Non-Hodgkin's lymphoma refractory","lang":"EN"},{"name":"难治性非霍奇金淋巴瘤","lang":"CN"}],[{"name":"Non-Small Cell Lung Cancer","lang":"EN"},{"name":"非小细胞肺癌","lang":"CN"}],[{"name":"Primary Cutaneous Anaplastic Large Cell Lymphoma","lang":"EN"},{"name":"原发性皮肤间变性大细胞淋巴瘤","lang":"CN"}],[{"name":"Recurrent Bladder Cancer","lang":"EN"},{"name":"复发性膀胱癌","lang":"CN"}],[{"name":"Recurrent cutaneous T-cell lymphoma","lang":"EN"},{"name":"复发性皮肤T细胞淋巴瘤","lang":"CN"}],[{"name":"Recurrent Non-Small Cell Lung Cancer","lang":"EN"},{"name":"复发性非小细胞肺癌","lang":"CN"}],[{"name":"Refractory Aggressive Non-Hodgkin Lymphoma","lang":"EN"},{"name":"难治性侵袭性非霍奇金淋巴瘤","lang":"CN"}],[{"name":"Sezary Syndrome","lang":"EN"},{"name":"塞扎里综合征","lang":"CN"}],[{"name":"Squamous cell carcinoma of head and neck metastatic","lang":"EN"},{"name":"转移性头颈部鳞状细胞癌","lang":"CN"}],[{"name":"T-cell lymphoma recurrent","lang":"EN"},{"name":"复发性T细胞淋巴瘤","lang":"CN"}],[{"name":"Urothelial Carcinoma of the Urinary Bladder","lang":"EN"},{"name":"膀胱尿路上皮癌","lang":"CN"}],[{"name":"Waldenstrom Macroglobulinemia","lang":"EN"},{"name":"巨球蛋白血症","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Pending","first_approved_date":1253750400000,"first_approved_indication":[[{"name":"Peripheral T-Cell Lymphoma","lang":"EN"},{"name":"外周T细胞淋巴瘤","lang":"CN"}]],"approval_country":["United States","China","Japan","Canada","Australia","South Korea"]}
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{"drug_name":[{"name":"布洛芬/愈创甘油醚/氢溴酸右美沙芬水合物/盐酸甲基麻黄碱/盐酸溴己新","lang":"CN"},{"name":"Ibuprofen/Guaifenesin/Dextromethorphan Hydrobromide Hydrate/DL-Methylephedrine Hydrochloride/Bromhexine Hydrochloride","lang":"EN"}],"target":[[{"name":"Cyclooxygenase-1","lang":"EN"},{"name":"环氧化酶-1","lang":"CN"}],[{"name":"Cyclooxygenase-2","lang":"EN"},{"name":"环氧化酶-2","lang":"CN"}],[{"name":"Glutamate [NMDA] receptor","lang":"EN"},{"name":"谷氨酸[NMDA]受体复合体","lang":"CN"}],[{"name":"Adrenergic receptors","lang":"EN"},{"name":"肾上腺素能受体家族","lang":"CN"}],[{"name":"Sigma opioid receptor","lang":"EN"},{"name":"σ-阿片受体","lang":"CN"}]],"disease":[[{"name":"Common Cold","lang":"EN"},{"name":"普通感冒","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Approved","first_approved_date":1754438400000,"first_approved_indication":[[{"name":"Common Cold","lang":"EN"},{"name":"普通感冒","lang":"CN"}]],"approval_country":["South Korea"]}
{"drug_name":[{"name":"伊努西单抗","lang":"CN"},{"name":"Ebronucimab","lang":"EN"}],"alias":[{"name":"Bixolecumab","lang":"EN"}],"target":[[{"name":"Proprotein convertase subtilisin kexin type 9","lang":"EN"},{"name":"前蛋白转化酶枯草杆菌蛋白酶Kexin-9","lang":"CN"}]],"disease":[[{"name":"Complex dyslipidemia","lang":"EN"},{"name":"复杂性血脂异常","lang":"CN"}],[{"name":"Heterozygous familial hypercholesterolemia","lang":"EN"},{"name":"杂合子家族性高胆固醇血症","lang":"CN"}],[{"name":"Primary hypercholesterolemia","lang":"EN"},{"name":"原发性高胆固醇血症","lang":"CN"}],[{"name":"Hypercholesterolemia","lang":"EN"},{"name":"高胆固醇血症","lang":"CN"}],[{"name":"Cardiovascular Diseases","lang":"EN"},{"name":"心血管疾病","lang":"CN"}],[{"name":"Homozygous familial hypercholesterolemia","lang":"EN"},{"name":"纯合子家族性高胆固醇血症","lang":"CN"}],[{"name":"Hyperlipidemia, Familial Combined","lang":"EN"},{"name":"家族性混合型高脂血症","lang":"CN"}]],"drug_type":["Monoclonal antibody"],"global_highest_dev_status":"Pending","first_approved_date":1727308800000,"first_approved_indication":[[{"name":"Complex dyslipidemia","lang":"EN"},{"name":"复杂性血脂异常","lang":"CN"}],[{"name":"Heterozygous familial hypercholesterolemia","lang":"EN"},{"name":"杂合子家族性高胆固醇血症","lang":"CN"}],[{"name":"Primary hypercholesterolemia","lang":"EN"},{"name":"原发性高胆固醇血症","lang":"CN"}]],"approval_country":["China"]}
{"drug_name":[{"name":"苯磺酸氨氯地平/奥美沙坦酯/瑞舒伐他汀钙","lang":"CN"},{"name":"Amlodipine Besylate/Olmesartan Medoxomil/Rosuvastatin Calcium","lang":"EN"}],"alias":[{"name":"Amlodipine besylate/olmersartan medoxomil/rosuvastatin calcium","lang":"EN"},{"name":"Amlodipine/olmesartan/rosuvastatin","lang":"EN"},{"name":"Olmersartan medoxomil/amlodipine besilate/rosuvastatin calcium","lang":"EN"},{"name":"Olmersartan medoxomil/amlodipine besylate/rosuvastatin calcium","lang":"EN"},{"name":"Olmesartan/amlodipine/rosuvastatin","lang":"EN"},{"name":"Olomax","lang":"EN"}],"target":[[{"name":"Angiotensin II Receptor Type 1","lang":"EN"},{"name":"血管紧张素II-1型受体","lang":"CN"}],[{"name":"HMG-CoA reductase","lang":"EN"},{"name":"羟甲基戊二酰辅酶A合酶","lang":"CN"}],[{"name":"Voltage-gated calcium channel","lang":"EN"},{"name":"电压门控性钙通道复合体","lang":"CN"}]],"disease":[[{"name":"Essential Hypertension","lang":"EN"},{"name":"原发性高血压","lang":"CN"}],[{"name":"Primary hypercholesterolemia","lang":"EN"},{"name":"原发性高胆固醇血症","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Approved","first_approved_date":1551225600000,"first_approved_indication":[[{"name":"Essential Hypertension","lang":"EN"},{"name":"原发性高血压","lang":"CN"}],[{"name":"Primary hypercholesterolemia","lang":"EN"},{"name":"原发性高胆固醇血症","lang":"CN"}]],"approval_country":["South Korea"]}
{"drug_name":[{"name":"Tirzepatide(Geropharm LLC)","lang":"EN"}],"target":[[{"name":"Gastric inhibitory polypeptide receptor","lang":"EN"},{"name":"肠抑胃肽受体","lang":"CN"}],[{"name":"Glucagon-like peptide 1 receptor","lang":"EN"},{"name":"胰高血糖素样肽-1受体","lang":"CN"}]],"disease":[[{"name":"Diabetes Mellitus","lang":"EN"},{"name":"糖尿病","lang":"CN"}],[{"name":"Obesity","lang":"EN"},{"name":"肥胖","lang":"CN"}]],"drug_type":["Synthetic peptide"],"global_highest_dev_status":"Approved","first_approved_date":1744848000000,"first_approved_indication":[[{"name":"Diabetes Mellitus","lang":"EN"},{"name":"糖尿病","lang":"CN"}],[{"name":"Obesity","lang":"EN"},{"name":"肥胖","lang":"CN"}]],"approval_country":["Russia"]}
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{"drug_name":[{"name":"度拉糖肽生物类似药 (博安生物)","lang":"CN"},{"name":"Dulaglutide Biosimilar (Boan Biotech)","lang":"EN"}],"alias":[{"name":"Dulaglutide Biosimilar (Shandong Boan Biotechnology Co., Ltd.)","lang":"EN"},{"name":"度拉糖肽生物类似药（山东博安生物技术股份有限公司）","lang":"CN"}],"target":[[{"name":"Glucagon-like peptide 1 receptor","lang":"EN"},{"name":"胰高血糖素样肽-1受体","lang":"CN"}]],"disease":[[{"name":"Diabetes Mellitus, Type 2","lang":"EN"},{"name":"2型糖尿病","lang":"CN"}]],"drug_type":["Fc fusion protein","Biosimilar"],"global_highest_dev_status":"Approved","first_approved_date":1754352000000,"first_approved_indication":[[{"name":"Diabetes Mellitus, Type 2","lang":"EN"},{"name":"2型糖尿病","lang":"CN"}]],"approval_country":["China"]}
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{"drug_name":[{"name":"布洛芬/无水咖啡因/DL-盐酸甲基麻黄碱/马来酸氯苯那敏/氢溴酸右美沙芬水合物/愈创甘油醚/盐酸伪麻黄碱","lang":"CN"},{"name":"Ibuprofen/Anhydrous Caffeine/DL-Methylephedrine Hydrochloride/Chlorpheniramine Maleate/Dextromethorphan Hydrobromide Hydrate/Guaifenesin/Pseudoephedrine Hydrochloride","lang":"EN"}],"target":[[{"name":"Adenosine A2a receptor","lang":"EN"},{"name":"腺苷A2a受体","lang":"CN"}],[{"name":"Cyclooxygenase-2","lang":"EN"},{"name":"环氧化酶-2","lang":"CN"}],[{"name":"Cyclooxygenase-1","lang":"EN"},{"name":"环氧化酶-1","lang":"CN"}],[{"name":"Histamine H1 receptor","lang":"EN"},{"name":"组胺H1受体","lang":"CN"}],[{"name":"Sigma opioid receptor","lang":"EN"},{"name":"σ-阿片受体","lang":"CN"}],[{"name":"Adenosine A1 receptor","lang":"EN"},{"name":"腺苷A1受体","lang":"CN"}],[{"name":"Carbonic anhydrase IX","lang":"EN"},{"name":"碳酸酐酶IX","lang":"CN"}]],"disease":[[{"name":"Common Cold","lang":"EN"},{"name":"普通感冒","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Approved","first_approved_date":1759276800000,"first_approved_indication":[[{"name":"Common Cold","lang":"EN"},{"name":"普通感冒","lang":"CN"}]],"approval_country":["South Korea"]}
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{"drug_name":[{"name":"培非格司亭生物类似药","lang":"CN"},{"name":"Pegfilgrastim  Biosimilar (JAMP Pharma Corp.)","lang":"EN"}],"alias":[{"name":"培非格司亭生物类似药（JAMP Pharma Corp.）","lang":"CN"}],"target":[[{"name":"Colony stimulating factor 3 receptor","lang":"EN"},{"name":"巨噬细胞集落刺激因子3受体","lang":"CN"}]],"disease":[[{"name":"Neutropenia","lang":"EN"},{"name":"中性粒细胞减少","lang":"CN"}]],"drug_type":["Biosimilar","Colony-stimulating factors"],"global_highest_dev_status":"Approved","first_approved_date":1733011200000,"first_approved_indication":[[{"name":"Neutropenia","lang":"EN"},{"name":"中性粒细胞减少","lang":"CN"}]],"approval_country":["Canada"]}
{"drug_name":[{"name":"贝伐珠单抗生物类似药 (上海复宏汉霖)","lang":"CN"},{"name":"Bevacizumab biosimilar(Shanghai Henlius)","lang":"EN"}],"alias":[{"name":"Bevacizumab Biosimilar (Shanghai Henlius Biotech, Inc.)","lang":"EN"},{"name":"Hanbeitai","lang":"EN"},{"name":"rhuMAb-VEGF biosimilar","lang":"EN"},{"name":"贝伐珠单抗生物类似药（上海复宏汉霖生物技术股份有限公司）","lang":"CN"},{"name":"重组抗VEGF人源化单抗 (上海复宏汉霖生物)","lang":"CN"}],"target":[[{"name":"Vascular endothelial growth factor A","lang":"EN"},{"name":"血管内皮生长因子A","lang":"CN"}]],"disease":[[{"name":"Fallopian Tube Carcinoma","lang":"EN"},{"name":"输卵管癌","lang":"CN"}],[{"name":"Ovarian Epithelial Carcinoma","lang":"EN"},{"name":"卵巢上皮癌","lang":"CN"}],[{"name":"Primary peritoneal carcinoma","lang":"EN"},{"name":"原发性腹膜癌","lang":"CN"}],[{"name":"Uterine Cervical Cancer","lang":"EN"},{"name":"宫颈癌","lang":"CN"}],[{"name":"Colorectal Cancer","lang":"EN"},{"name":"结直肠癌","lang":"CN"}],[{"name":"Non-Small Cell Lung Cancer","lang":"EN"},{"name":"非小细胞肺癌","lang":"CN"}],[{"name":"Glioblastoma","lang":"EN"},{"name":"胶质母细胞瘤","lang":"CN"}],[{"name":"Metastatic Colorectal Carcinoma","lang":"EN"},{"name":"转移性结直肠癌","lang":"CN"}],[{"name":"Oncocytoma, Renal","lang":"EN"},{"name":"肾嗜酸细胞瘤","lang":"CN"}],[{"name":"Ovarian Cancer","lang":"EN"},{"name":"卵巢癌","lang":"CN"}],[{"name":"Wet age-related macular degeneration","lang":"EN"},{"name":"湿性年龄相关性黄斑变性","lang":"CN"}],[{"name":"Non-squamous non-small cell lung cancer","lang":"EN"},{"name":"非鳞状非小细胞肺癌","lang":"CN"}],[{"name":"Advanced Lung Non-Squamous Non-Small Cell Carcinoma","lang":"EN"},{"name":"晚期肺非鳞状非小细胞癌","lang":"CN"}],[{"name":"Carcinoma","lang":"EN"},{"name":"恶性上皮肿瘤","lang":"CN"}],[{"name":"Squamous non-small cell lung cancer","lang":"EN"},{"name":"鳞状非小细胞肺癌","lang":"CN"}],[{"name":"Portal Vein Thrombosis","lang":"EN"},{"name":"门静脉血栓形成","lang":"CN"}],[{"name":"Advanced Hepatocellular Carcinoma","lang":"EN"},{"name":"晚期肝细胞癌","lang":"CN"}],[{"name":"Advanced Malignant Solid Neoplasm","lang":"EN"},{"name":"晚期恶性实体瘤","lang":"CN"}]],"drug_type":["Biosimilar","Monoclonal antibody"],"global_highest_dev_status":"Approved","first_approved_date":1638230400000,"first_approved_indication":[[{"name":"Colorectal Cancer","lang":"EN"},{"name":"结直肠癌","lang":"CN"}],[{"name":"Non-Small Cell Lung Cancer","lang":"EN"},{"name":"非小细胞肺癌","lang":"CN"}]],"approval_country":["China","Bolivia"]}
{"drug_name":[{"name":"Glycol Salicylate/L-Menthol/Vanillyl Nonylamide/Tocopherol Acetate","lang":"EN"}],"target":[[{"name":"Free radicals","lang":"EN"},{"name":"自由基","lang":"CN"}],[{"name":"Transient receptor potential cation channel subfamily A member 1","lang":"EN"},{"name":"瞬时受体电位离子通道亚基1","lang":"CN"}],[{"name":"Transient receptor potential cation channel subfamily M member 8","lang":"EN"},{"name":"瞬时受体电位阳离子通道M8","lang":"CN"}],[{"name":"Transient receptor potential cation channel subfamily V member 1","lang":"EN"},{"name":"类香草素受体","lang":"CN"}],[{"name":"Kappa opioid receptor","lang":"EN"},{"name":"κ-阿片受体","lang":"CN"}]],"disease":[[{"name":"Insect Bites and Stings","lang":"EN"},{"name":"昆虫咬伤和螫伤","lang":"CN"}],[{"name":"Pain","lang":"EN"},{"name":"疼痛","lang":"CN"}],[{"name":"Pruritis (itchy skin)","lang":"EN"},{"name":"瘙痒（皮肤发痒）","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Approved","first_approved_date":1745452800000,"first_approved_indication":[[{"name":"Insect Bites and Stings","lang":"EN"},{"name":"昆虫咬伤和螫伤","lang":"CN"}],[{"name":"Pain","lang":"EN"},{"name":"疼痛","lang":"CN"}],[{"name":"Pruritis (itchy skin)","lang":"EN"},{"name":"瘙痒（皮肤发痒）","lang":"CN"}]],"approval_country":["South Korea"]}
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{"drug_name":[{"name":"非格司亭生物类似药(KASHIV BIOSCIENCES LLC)","lang":"CN"},{"name":"Filgrastim biosimilar(KASHIV BIOSCIENCES LLC)","lang":"EN"}],"alias":[{"name":"FILGRASTIM-AYOW","lang":"EN"}],"target":[[{"name":"Colony stimulating factor 3 receptor","lang":"EN"},{"name":"巨噬细胞集落刺激因子3受体","lang":"CN"}]],"disease":[[{"name":"Febrile Neutropenia","lang":"EN"},{"name":"粒细胞减少性发热","lang":"CN"}],[{"name":"Neutropenia","lang":"EN"},{"name":"中性粒细胞减少","lang":"CN"}]],"drug_type":["Biosimilar","Colony-stimulating factors"],"global_highest_dev_status":"Approved","first_approved_date":1645747200000,"first_approved_indication":[[{"name":"Febrile Neutropenia","lang":"EN"},{"name":"粒细胞减少性发热","lang":"CN"}],[{"name":"Neutropenia","lang":"EN"},{"name":"中性粒细胞减少","lang":"CN"}]],"approval_country":["United States"]}
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{"drug_name":[{"name":"硫酸伪麻黄碱","lang":"CN"},{"name":"Pseudoephedrine Sulfate","lang":"EN"}],"alias":[{"name":"Pseudoephedrine sulfate (USP)","lang":"EN"},{"name":"Pseudoephrine Sulfate","lang":"EN"}],"target":[[{"name":"Adrenergic receptor alpha-1","lang":"EN"},{"name":"肾上腺素能受体α-1家族","lang":"CN"}],[{"name":"Adrenergic receptors alpha-2","lang":"EN"},{"name":"肾上腺素能受体α-2家族","lang":"CN"}],[{"name":"Beta-1 adrenergic receptor","lang":"EN"},{"name":"β1-肾上腺素能受体","lang":"CN"}],[{"name":"Beta-2 adrenergic receptor","lang":"EN"},{"name":"β2-肾上腺素能受体","lang":"CN"}],[{"name":"Beta-3 adrenergic receptor","lang":"EN"},{"name":"β3-肾上腺素能受体","lang":"CN"}]],"disease":[[{"name":"Nasal Obstruction","lang":"EN"},{"name":"鼻塞","lang":"CN"}],[{"name":"Congestion of nasal mucosa","lang":"EN"},{"name":"鼻粘膜充血","lang":"CN"}],[{"name":"Rhinitis, Allergic","lang":"EN"},{"name":"过敏性鼻炎","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Withdrawn","first_approved_date":341712000000,"first_approved_indication":[[{"name":"Congestion of nasal mucosa","lang":"EN"},{"name":"鼻粘膜充血","lang":"CN"}],[{"name":"Rhinitis, Allergic","lang":"EN"},{"name":"过敏性鼻炎","lang":"CN"}]],"approval_country":["China"]}
{"drug_name":[{"name":"伯舒替尼","lang":"CN"},{"name":"Bosutinib Monohydrate","lang":"EN"},{"name":"ボスチニブ水和物","lang":"JP"}],"alias":[{"name":"BOSUTINIB","lang":"EN"},{"name":"Bosutinib Hydrate","lang":"EN"},{"name":"Bosutinib hydrate (JAN)","lang":"EN"},{"name":"bosutinib (as monohydrate)","lang":"EN"},{"name":"博苏替尼","lang":"CN"}],"target":[[{"name":"Bcr-Abl tyrosine kinase","lang":"EN"},{"name":"bcr-abl酪氨酸激酶","lang":"CN"}],[{"name":"Tyrosine-protein kinase SRC","lang":"EN"},{"name":"酪氨酸蛋白激酶SRC","lang":"CN"}]],"disease":[[{"name":"Chronic Myelogenous Leukemia","lang":"EN"},{"name":"慢性粒细胞性白血病","lang":"CN"}],[{"name":"Ductus Arteriosus, Patent","lang":"EN"},{"name":"动脉导管未闭","lang":"CN"}],[{"name":"Accelerated phase Philadelphia chromosome positive chronic myeloid leukemia","lang":"EN"},{"name":"加速期费城染色体阳性慢性粒细胞白血病","lang":"CN"}],[{"name":"Philadelphia chromosome positive chronic myeloid leukemia in blast crisis","lang":"EN"},{"name":"急变期费城染色体阳性慢性粒细胞白血病","lang":"CN"}],[{"name":"Philadelphia chromosome-positive chronic myeloid  leukemia in chronic phase","lang":"EN"},{"name":"慢性期费城染色体阳性慢性粒细胞白血病","lang":"CN"}],[{"name":"Philadelphia chromosome positive chronic myelogenous leukemia","lang":"EN"},{"name":"费城染色体阳性慢性粒细胞白血病","lang":"CN"}],[{"name":"Aggressive-Phase Chronic Myelocytic Leukemia","lang":"EN"},{"name":"加速期慢性骨髄性白血病","lang":"CN"}],[{"name":"Blast Phase Chronic Granulocytic Leukemia","lang":"EN"},{"name":"急性转化期慢性粒细胞性白血病","lang":"CN"}],[{"name":"Chronic phase chronic myeloid leukemia","lang":"EN"},{"name":"慢性期慢性髓性白血病","lang":"CN"}],[{"name":"Amyotrophic Lateral Sclerosis","lang":"EN"},{"name":"肌萎缩侧索硬化","lang":"CN"}],[{"name":"Hormone receptor positive breast cancer","lang":"EN"},{"name":"HR阳性乳腺癌","lang":"CN"}],[{"name":"Hormone receptor positive HER2 negative breast cancer","lang":"EN"},{"name":"HR阳性/HER2阴性乳腺癌","lang":"CN"}],[{"name":"Human epidermal growth factor 2 negative carcinoma of breast","lang":"EN"},{"name":"HEGF2阴性乳腺癌","lang":"CN"}],[{"name":"Lewy Body Disease","lang":"EN"},{"name":"路易体病","lang":"CN"}],[{"name":"Advanced Bile Duct Carcinoma","lang":"EN"},{"name":"晚期胆管癌","lang":"CN"}],[{"name":"Advanced breast cancer","lang":"EN"},{"name":"晚期乳腺癌","lang":"CN"}],[{"name":"Advanced Colorectal Adenocarcinoma","lang":"EN"},{"name":"晚期结直肠腺癌","lang":"CN"}],[{"name":"Advanced Malignant Solid Neoplasm","lang":"EN"},{"name":"晚期恶性实体瘤","lang":"CN"}],[{"name":"Chronic leukemia","lang":"EN"},{"name":"慢性白血病","lang":"CN"}],[{"name":"Glioblastoma Multiforme","lang":"EN"},{"name":"多形性胶质母细胞瘤","lang":"CN"}],[{"name":"Locally advanced breast cancer","lang":"EN"},{"name":"局部晚期乳腺癌","lang":"CN"}],[{"name":"Metastatic breast cancer","lang":"EN"},{"name":"转移性乳腺癌","lang":"CN"}],[{"name":"Pancreatic Cancer","lang":"EN"},{"name":"胰腺癌","lang":"CN"}],[{"name":"Philadelphia Chromosome Positive Leukemia","lang":"EN"},{"name":"费城染色体阳性白血病","lang":"CN"}],[{"name":"Polycystic Kidney, Autosomal Dominant","lang":"EN"},{"name":"常染色体显性多囊肾病","lang":"CN"}],[{"name":"Recurrent Glioblastoma","lang":"EN"},{"name":"复发性胶质母细胞瘤","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Pending","first_approved_date":1346716800000,"first_approved_indication":[[{"name":"Philadelphia chromosome positive chronic myelogenous leukemia","lang":"EN"},{"name":"费城染色体阳性慢性粒细胞白血病","lang":"CN"}]],"approval_country":["United States","European Union","Japan","Australia","Iceland","Liechtenstein","Norway"]}
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{"drug_name":[{"name":"磷酸瑞格列汀","lang":"CN"},{"name":"Retagliptin Phosphate","lang":"EN"}],"alias":[{"name":"瑞格列汀","lang":"CN"}],"target":[[{"name":"Dipeptidyl peptidase IV","lang":"EN"},{"name":"二肽基肽酶IV","lang":"CN"}]],"disease":[[{"name":"Diabetes Mellitus, Type 2","lang":"EN"},{"name":"2型糖尿病","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Approved","first_approved_date":1687824000000,"first_approved_indication":[[{"name":"Diabetes Mellitus, Type 2","lang":"EN"},{"name":"2型糖尿病","lang":"CN"}]],"approval_country":["China"]}
{"drug_name":[{"name":"马塔西单抗","lang":"CN"},{"name":"Marstacimab-hncq","lang":"EN"},{"name":"マルスタシマブ（遺伝子組換え）","lang":"JP"}],"alias":[{"name":"Marstacimab","lang":"EN"},{"name":"Marstacimab (USAN)","lang":"EN"}],"target":[[{"name":"Tissue factor pathway inhibitor","lang":"EN"},{"name":"组织因子通道抑制剂","lang":"CN"}]],"disease":[[{"name":"Hemophilia A","lang":"EN"},{"name":"血友病A","lang":"CN"}],[{"name":"Hemophilia B","lang":"EN"},{"name":"血友病B","lang":"CN"}]],"drug_type":["Monoclonal antibody"],"global_highest_dev_status":"Approved","first_approved_date":1728604800000,"first_approved_indication":[[{"name":"Hemophilia A","lang":"EN"},{"name":"血友病A","lang":"CN"}],[{"name":"Hemophilia B","lang":"EN"},{"name":"血友病B","lang":"CN"}]],"approval_country":["United States","China","European Union","Japan","United Kingdom","Australia","Iceland","South Korea","Liechtenstein","Norway"]}
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{"drug_name":[{"name":"富马酸泰吉利定","lang":"CN"},{"name":"Tegileridine Fumarate","lang":"EN"}],"target":[[{"name":"Mu opioid receptor","lang":"EN"},{"name":"μ-阿片受体","lang":"CN"}]],"disease":[[{"name":"Pain, Postoperative","lang":"EN"},{"name":"术后疼痛","lang":"CN"}],[{"name":"Analgesia","lang":"EN"},{"name":"镇痛","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Phase 2 Clinical","first_approved_date":1706572800000,"first_approved_indication":[[{"name":"Pain, Postoperative","lang":"EN"},{"name":"术后疼痛","lang":"CN"}]],"approval_country":["China"]}
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{"drug_name":[{"name":"人凝血酶原复合物(Octapharma)","lang":"CN"},{"name":"Human prothrombin complex (Octapharma)","lang":"EN"}],"alias":[{"name":"4 Factor Prothrombin Concentrate Complex - Octapharma","lang":"EN"},{"name":"4-FACTOR PCC","lang":"EN"},{"name":"4F PCC","lang":"EN"},{"name":"Human prothrombin complex","lang":"EN"},{"name":"Ocplex","lang":"EN"},{"name":"Octaplex","lang":"EN"},{"name":"Pronativ","lang":"EN"},{"name":"prothrombin complex concentrate, human-lans","lang":"EN"}],"target":[[{"name":"Coagulation factor X","lang":"EN"},{"name":"凝血因子X","lang":"CN"}],[{"name":"Coagulation factor IX","lang":"EN"},{"name":"凝血因子IX","lang":"CN"}],[{"name":"Coagulation factor VII","lang":"EN"},{"name":"凝血因子VII","lang":"CN"}],[{"name":"Factor IIa","lang":"EN"},{"name":"激活型凝血因子II","lang":"CN"}]],"disease":[[{"name":"Acquired coagulation factor deficiency","lang":"EN"},{"name":"获得性凝血因子缺乏","lang":"CN"}],[{"name":"Hemorrhage","lang":"EN"},{"name":"出血","lang":"CN"}]],"drug_type":["Non-recombinant coagulation factor"],"global_highest_dev_status":"Phase 3 Clinical","first_approved_date":1689897600000,"first_approved_indication":[[{"name":"Acquired coagulation factor deficiency","lang":"EN"},{"name":"获得性凝血因子缺乏","lang":"CN"}]],"approval_country":["United States"]}
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{"drug_name":[{"name":"左亚叶酸钙","lang":"CN"},{"name":"Levofolinate Calcium","lang":"EN"},{"name":"レボホリナートカルシウム","lang":"JP"}],"alias":[{"name":"Calcium Levofolinate","lang":"EN"},{"name":"Calcium Levofolinate Hydrate","lang":"EN"},{"name":"Calcium levofolinate (INN)","lang":"EN"},{"name":"LEVOLEUCOVORIN CALCIUM","lang":"EN"},{"name":"Levofolinate calcium (JAN)","lang":"EN"},{"name":"Levoleucovorin calcium (USAN)","lang":"EN"}],"target":[[{"name":"Thymidylate synthase","lang":"EN"},{"name":"胸苷酸合成酶","lang":"CN"}]],"disease":[[{"name":"Small intestine carcinoma","lang":"EN"},{"name":"小肠癌","lang":"CN"}],[{"name":"Pancreatic Cancer","lang":"EN"},{"name":"胰腺癌","lang":"CN"}],[{"name":"Colorectal Cancer","lang":"EN"},{"name":"结直肠癌","lang":"CN"}],[{"name":"Stomach Cancer","lang":"EN"},{"name":"胃癌","lang":"CN"}],[{"name":"Drug intoxication","lang":"EN"},{"name":"药物中毒","lang":"CN"}],[{"name":"Mucositis","lang":"EN"},{"name":"粘膜炎","lang":"CN"}],[{"name":"Non-Hodgkin's lymphoma refractory","lang":"EN"},{"name":"难治性非霍奇金淋巴瘤","lang":"CN"}],[{"name":"Osteosarcoma","lang":"EN"},{"name":"骨肉瘤","lang":"CN"}],[{"name":"recurrent gastric cancer","lang":"EN"},{"name":"复发性胃癌","lang":"CN"}],[{"name":"Recurrent Non-Small Cell Lung Cancer","lang":"EN"},{"name":"复发性非小细胞肺癌","lang":"CN"}],[{"name":"Stage III Colon Cancer","lang":"EN"},{"name":"III期结肠癌","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Discontinued","first_approved_date":929491200000,"first_approved_indication":[[{"name":"Stomach Cancer","lang":"EN"},{"name":"胃癌","lang":"CN"}]],"approval_country":["China","Japan"]}
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{"drug_name":[{"name":"地喹氯铵","lang":"CN"},{"name":"Dequalinium Chloride","lang":"EN"},{"name":"デカリニウム塩化物","lang":"JP"}],"alias":[{"name":"Degualinium Chloride","lang":"EN"},{"name":"Dequalinium chloride (JAN/INN)","lang":"EN"},{"name":"dequalinium chloride vaginal tablets","lang":"EN"}],"target":[[{"name":"Enzymes","lang":"EN"},{"name":"酶","lang":"CN"}]],"disease":[[{"name":"Bacterial Vaginosis","lang":"EN"},{"name":"细菌性阴道炎","lang":"CN"}],[{"name":"Stomatitis","lang":"EN"},{"name":"口腔炎","lang":"CN"}],[{"name":"Candidiasis, Vulvovaginal","lang":"EN"},{"name":"外阴阴道念珠菌病","lang":"CN"}],[{"name":"Infective vaginitis","lang":"EN"},{"name":"感染性阴道炎","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Withdrawn","first_approved_date":820454400000,"first_approved_indication":[[{"name":"Stomatitis","lang":"EN"},{"name":"口腔炎","lang":"CN"}]],"approval_country":["China","Canada","Belgium","Czechia","Germany","Slovakia"]}
{"drug_name":[{"name":"新型冠状病毒变异株mRNA疫苗 (沃森生物)","lang":"CN"},{"name":"SARS-CoV-2 mRNA Vaccine (Variants) (Walvax Biotechnology)","lang":"EN"}],"alias":[{"name":"Omicron XBB.1.5 (Walvax Biotechnology)","lang":"EN"},{"name":"新型冠状病毒变异株mRNA疫苗（Omicron XBB.1.5）(沃森生物)","lang":"CN"}],"target":[[{"name":"SARS-CoV-2 S protein","lang":"EN"},{"name":"新冠病毒刺突蛋白","lang":"CN"}]],"disease":[[{"name":"COVID-19","lang":"EN"},{"name":"新型冠状病毒感染","lang":"CN"}]],"drug_type":["Prophylactic vaccine","mRNA vaccine"],"global_highest_dev_status":"Approved","first_approved_date":1701388800000,"first_approved_indication":[[{"name":"COVID-19","lang":"EN"},{"name":"新型冠状病毒感染","lang":"CN"}]],"approval_country":["China"]}
{"drug_name":[{"name":"重组人白蛋白（水稻）（武汉禾元）","lang":"CN"},{"name":"Recombinant human serum albuminfrom OsrHSA (Wuhan Healthgen)","lang":"EN"}],"alias":[{"name":"OsrHSA","lang":"EN"},{"name":"Recombinant Human SerumAlbumin from Oryza Sativa","lang":"EN"},{"name":"Recombinant human serum albumin (Wuhan Healthgen)","lang":"EN"},{"name":"植物源重组人血清白蛋白（武汉禾元）","lang":"CN"}],"target":[[{"name":"Serum albumin","lang":"EN"},{"name":"血清白蛋白","lang":"CN"}]],"disease":[[{"name":"Hypoalbuminemia","lang":"EN"},{"name":"低白蛋白血症","lang":"CN"}],[{"name":"Hypovolemia","lang":"EN"},{"name":"血容量不足","lang":"CN"}],[{"name":"Decompensated cirrhosis of liver","lang":"EN"},{"name":"失代偿性肝硬化","lang":"CN"}],[{"name":"Hepatic ascites","lang":"EN"},{"name":"肝腹水症","lang":"CN"}],[{"name":"Edema","lang":"EN"},{"name":"水肿","lang":"CN"}],[{"name":"Fibrosis","lang":"EN"},{"name":"纤维化","lang":"CN"}]],"drug_type":["Recombinant protein"],"global_highest_dev_status":"Phase 2 Clinical","first_approved_date":1752537600000,"first_approved_indication":[[{"name":"Hypoalbuminemia","lang":"EN"},{"name":"低白蛋白血症","lang":"CN"}]],"approval_country":["China"]}
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{"drug_name":[{"name":"恩那司他","lang":"CN"},{"name":"Enarodustat","lang":"EN"},{"name":"エナロデュスタット","lang":"JP"}],"alias":[{"name":"Enarodustat (JAN)","lang":"EN"},{"name":"恩那度司他","lang":"CN"}],"target":[[{"name":"Hypoxia-inducible factor prolyl hydroxylase","lang":"EN"},{"name":"缺氧诱导因子脯氨酰羟化酶家族","lang":"CN"}]],"disease":[[{"name":"chronic renal failure anemia","lang":"EN"},{"name":"慢性肾衰竭贫血","lang":"CN"}],[{"name":"Anemia of renal disease","lang":"EN"},{"name":"肾性贫血","lang":"CN"}],[{"name":"Kidney Diseases","lang":"EN"},{"name":"肾脏疾病","lang":"CN"}],[{"name":"Chronic Kidney Diseases","lang":"EN"},{"name":"慢性肾病","lang":"CN"}],[{"name":"Altitude Sickness","lang":"EN"},{"name":"高原反应","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Phase 3 Clinical","first_approved_date":1600992000000,"first_approved_indication":[[{"name":"Anemia of renal disease","lang":"EN"},{"name":"肾性贫血","lang":"CN"}]],"approval_country":["China","Japan","South Korea"]}
{"drug_name":[{"name":"利妥昔单抗生物类似药(Amgen, Inc.)","lang":"CN"},{"name":"Rituximab-arrx(Amgen, Inc.)","lang":"EN"}],"alias":[{"name":"RIABNI","lang":"EN"},{"name":"Rituximab biosimilar","lang":"EN"}],"target":[[{"name":"B-lymphocyte antigen CD20","lang":"EN"},{"name":"B淋巴细胞抗原CD20","lang":"CN"}]],"disease":[[{"name":"Rheumatoid Arthritis","lang":"EN"},{"name":"类风湿关节炎","lang":"CN"}],[{"name":"Chronic Lymphocytic Leukemia","lang":"EN"},{"name":"慢性淋巴细胞白血病","lang":"CN"}],[{"name":"Granulomatosis With Polyangiitis","lang":"EN"},{"name":"肉芽肿伴多血管炎","lang":"CN"}],[{"name":"Microscopic Polyangiitis","lang":"EN"},{"name":"显微镜下多血管炎","lang":"CN"}],[{"name":"Non-Hodgkin Lymphoma","lang":"EN"},{"name":"非霍奇金淋巴瘤","lang":"CN"}],[{"name":"CD20 Positive B-Cell Non-Hodgkin Lymphoma","lang":"EN"},{"name":"CD20阳性的B细胞非霍奇金淋巴瘤","lang":"CN"}]],"drug_type":["Biosimilar","Monoclonal antibody"],"global_highest_dev_status":"Approved","first_approved_date":1608163200000,"first_approved_indication":[[{"name":"Chronic Lymphocytic Leukemia","lang":"EN"},{"name":"慢性淋巴细胞白血病","lang":"CN"}],[{"name":"Granulomatosis With Polyangiitis","lang":"EN"},{"name":"肉芽肿伴多血管炎","lang":"CN"}],[{"name":"Microscopic Polyangiitis","lang":"EN"},{"name":"显微镜下多血管炎","lang":"CN"}],[{"name":"Non-Hodgkin Lymphoma","lang":"EN"},{"name":"非霍奇金淋巴瘤","lang":"CN"}]],"approval_country":["United States","Canada"]}
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{"drug_name":[{"name":"Atidarsagene Autotemcel","lang":"EN"}],"alias":[{"name":"ARSA gene therapy","lang":"EN"},{"name":"Arsa-cel","lang":"EN"},{"name":"Autologous CD34+ cells encoding ARSA gene","lang":"EN"},{"name":"Lenmeldy","lang":"EN"}],"target":[[{"name":"Cerebroside-sulfatase","lang":"EN"},{"name":"脑苷脂硫酸酶","lang":"CN"}]],"disease":[[{"name":"Leukodystrophy, Metachromatic","lang":"EN"},{"name":"异染性脑白质病变","lang":"CN"}]],"drug_type":["Gene therapy","Hematopoietic stem cell therapy"],"global_highest_dev_status":"Approved","first_approved_date":1608163200000,"first_approved_indication":[[{"name":"Leukodystrophy, Metachromatic","lang":"EN"},{"name":"异染性脑白质病变","lang":"CN"}]],"approval_country":["United States","European Union","United Kingdom","Switzerland","Germany","France","Iceland","Italy","Liechtenstein","Norway"]}
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{"drug_name":[{"name":"对乙酰氨基酚/核黄素磷酸钠","lang":"CN"},{"name":"Acetaminophen/Riboflavin Sodium Phosphate","lang":"EN"}],"target":[[{"name":"Cyclooxygenases","lang":"EN"},{"name":"环氧化酶","lang":"CN"}]],"disease":[[{"name":"Fever","lang":"EN"},{"name":"发热","lang":"CN"}],[{"name":"Pain","lang":"EN"},{"name":"疼痛","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Approved","first_approved_date":1750636800000,"first_approved_indication":[[{"name":"Fever","lang":"EN"},{"name":"发热","lang":"CN"}],[{"name":"Pain","lang":"EN"},{"name":"疼痛","lang":"CN"}]],"approval_country":["South Korea"]}
{"drug_name":[{"name":"西格列汀/盐酸二甲双胍","lang":"CN"},{"name":"Sitagliptin/Metformin Hydrochloride","lang":"EN"}],"target":[[{"name":"Dipeptidyl peptidase IV","lang":"EN"},{"name":"二肽基肽酶IV","lang":"CN"}],[{"name":"Protein kinase AMP-activated non-catalytic subunit beta 1","lang":"EN"},{"name":"腺苷酸活化蛋白激酶亚基β1","lang":"CN"}]],"disease":[[{"name":"Diabetes Mellitus, Type 2","lang":"EN"},{"name":"2型糖尿病","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Approved","first_approved_date":1698969600000,"first_approved_indication":[[{"name":"Diabetes Mellitus, Type 2","lang":"EN"},{"name":"2型糖尿病","lang":"CN"}]],"approval_country":["United States"]}
{"drug_name":[{"name":"重组新型冠状病毒融合蛋白疫苗","lang":"CN"},{"name":"Recombinant Covid-19 Fusion Protein Vaccine(Livzon Mabpharm/Institute of Biophysics, Chinese Academy of Sciences)","lang":"EN"}],"alias":[{"name":"Recombinant SARSCoV2 Fusion Protein Vaccine","lang":"EN"},{"name":"Recombinant coronavirus fusion protein vaccine Livzon Mabpharm/Institute of Biophysics Chinese Academy of Sciences","lang":"EN"},{"name":"V01 Livzon Mabpharm/Institute of Biophysics Chinese Academy of Sciences","lang":"EN"},{"name":"丽康V-01","lang":"CN"}],"target":[[{"name":"SARS-CoV-2 S protein","lang":"EN"},{"name":"新冠病毒刺突蛋白","lang":"CN"}]],"disease":[[{"name":"COVID-19","lang":"EN"},{"name":"新型冠状病毒感染","lang":"CN"}]],"drug_type":["Prophylactic vaccine","Fusion protein"],"global_highest_dev_status":"Approved","first_approved_date":1662076800000,"first_approved_indication":[[{"name":"COVID-19","lang":"EN"},{"name":"新型冠状病毒感染","lang":"CN"}]],"approval_country":["China"]}
{"drug_name":[{"name":"Metazosin","lang":"EN"}],"alias":[{"name":"Kenosin","lang":"EN"}],"target":[[{"name":"Adrenergic receptor alpha-1","lang":"EN"},{"name":"肾上腺素能受体α-1家族","lang":"CN"}]],"disease":[[{"name":"Hypertension","lang":"EN"},{"name":"高血压","lang":"CN"}],[{"name":"Glaucoma","lang":"EN"},{"name":"青光眼","lang":"CN"}],[{"name":"Heart Failure","lang":"EN"},{"name":"心脏衰竭","lang":"CN"}],[{"name":"Prostatic Hyperplasia","lang":"EN"},{"name":"前列腺增生症","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Discontinued","first_approved_date":786758400000,"first_approved_indication":[[{"name":"Hypertension","lang":"EN"},{"name":"高血压","lang":"CN"}]],"approval_country":["Czechia"]}
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{"drug_name":[{"name":"莫匹罗星钙二水合物","lang":"CN"},{"name":"Mupirocin Calcium","lang":"EN"},{"name":"ムピロシンカルシウム水和物","lang":"JP"}],"alias":[{"name":"MUP","lang":"EN"},{"name":"Mupirocin Calcium Hydrate","lang":"EN"},{"name":"Mupirocin calcium (USP)","lang":"EN"},{"name":"Mupirocin calcium dihydrate","lang":"EN"},{"name":"Mupirocin calcium hydrate (JP17)","lang":"EN"},{"name":"mupirocin","lang":"EN"}],"target":[[{"name":"Isoleucyl-tRNA synthetase","lang":"EN"},{"name":"异亮氨酰-tRNA合成酶","lang":"CN"}]],"disease":[[{"name":"MRSA - Methicillin resistant Staphylococcus aureus infection","lang":"EN"},{"name":"耐甲氧西林金黄色葡萄球菌感染","lang":"CN"}],[{"name":"Staphylococcal Infections","lang":"EN"},{"name":"葡萄球菌感染","lang":"CN"}],[{"name":"Impetigo","lang":"EN"},{"name":"脓疱疮","lang":"CN"}],[{"name":"Streptococcal Infections","lang":"EN"},{"name":"链球菌感染","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Withdrawn","first_approved_date":682128000000,"first_approved_indication":[[{"name":"Staphylococcal Infections","lang":"EN"},{"name":"葡萄球菌感染","lang":"CN"}]],"approval_country":["Japan","Australia"]}
{"drug_name":[{"name":"羟乙磺酸达尔西利","lang":"CN"},{"name":"Dalpiciclib Isethionate","lang":"EN"}],"alias":[{"name":"Dalpiciclib","lang":"EN"},{"name":"达尔西利","lang":"CN"}],"target":[[{"name":"Cyclin-dependent kinase 4","lang":"EN"},{"name":"细胞周期蛋白依赖性激酶4","lang":"CN"}],[{"name":"Cyclin-dependent kinase 6","lang":"EN"},{"name":"细胞周期蛋白依赖性激酶6","lang":"CN"}]],"disease":[[{"name":"Hormone receptor positive HER2 negative breast cancer","lang":"EN"},{"name":"HR阳性/HER2阴性乳腺癌","lang":"CN"}],[{"name":"HER2-negative breast cancer","lang":"EN"},{"name":"HER2 阴性乳腺癌","lang":"CN"}],[{"name":"Hormone receptor positive breast cancer","lang":"EN"},{"name":"HR阳性乳腺癌","lang":"CN"}],[{"name":"Node-positive breast cancer","lang":"EN"},{"name":"淋巴结阳性乳腺癌","lang":"CN"}],[{"name":"Advanced breast cancer","lang":"EN"},{"name":"晚期乳腺癌","lang":"CN"}],[{"name":"HER2 Positive Breast Cancer","lang":"EN"},{"name":"HER2阳性乳腺癌","lang":"CN"}],[{"name":"HR Positive/HER2 Negative/Node positive breast cancer","lang":"EN"},{"name":"HR阳性HER2阴性淋巴结阳性乳腺癌","lang":"CN"}],[{"name":"Metastatic castration-resistant prostate cancer","lang":"EN"},{"name":"转移性去势抵抗性前列腺癌","lang":"CN"}],[{"name":"Advanced Lung Non-Small Cell Carcinoma","lang":"EN"},{"name":"晚期非小细胞肺癌","lang":"CN"}],[{"name":"Visceral spasms","lang":"EN"},{"name":"内脏痉挛","lang":"CN"}],[{"name":"Advanced HER2-Positive Breast Carcinoma","lang":"EN"},{"name":"晚期 HER2 阳性乳腺癌","lang":"CN"}],[{"name":"Metastatic breast cancer","lang":"EN"},{"name":"转移性乳腺癌","lang":"CN"}],[{"name":"Metastatic human epidermal growth factor 2 positive carcinoma of breast","lang":"EN"},{"name":"HER2阳性转移性乳腺癌","lang":"CN"}],[{"name":"Advanced Malignant Solid Neoplasm","lang":"EN"},{"name":"晚期恶性实体瘤","lang":"CN"}],[{"name":"Protein Deficiency","lang":"EN"},{"name":"蛋白质缺乏","lang":"CN"}],[{"name":"ER-positive/HER2-negative Breast Cancer","lang":"EN"},{"name":"ER阳性/HER2阴性乳腺癌","lang":"CN"}],[{"name":"Hormone receptor positive HER2 positive breast cancer","lang":"EN"},{"name":"HR阳性/HER2阳性乳腺癌","lang":"CN"}],[{"name":"Melanoma","lang":"EN"},{"name":"黑色素瘤","lang":"CN"}],[{"name":"Castration-sensitive prostate cancer","lang":"EN"},{"name":"去势敏感前列腺癌","lang":"CN"}],[{"name":"KRAS G12D mutation Solid Tumors","lang":"EN"},{"name":"KRAS G12D突变实体瘤","lang":"CN"}],[{"name":"Advanced Colorectal Adenocarcinoma","lang":"EN"},{"name":"晚期结直肠腺癌","lang":"CN"}],[{"name":"Advanced Hepatocellular Carcinoma","lang":"EN"},{"name":"晚期肝细胞癌","lang":"CN"}],[{"name":"Disease Progression","lang":"EN"},{"name":"疾病进展","lang":"CN"}],[{"name":"ER-positive/HER2-positive Breast Cancer","lang":"EN"},{"name":"ER阳性/HER2阳性乳腺癌","lang":"CN"}],[{"name":"Esophageal Squamous Cell Carcinoma","lang":"EN"},{"name":"食管鳞状细胞癌","lang":"CN"}],[{"name":"Estrogen receptor positive breast cancer","lang":"EN"},{"name":"ER阳性乳腺癌","lang":"CN"}],[{"name":"Ewing Sarcoma","lang":"EN"},{"name":"尤文肉瘤","lang":"CN"}],[{"name":"HER2 Positive Stomach Adenocarcinoma","lang":"EN"},{"name":"HER2阳性胃腺癌","lang":"CN"}],[{"name":"HER2-Low Breast Carcinoma","lang":"EN"},{"name":"HER2低表达乳腺癌","lang":"CN"}],[{"name":"HER2-positive gastric cancer","lang":"EN"},{"name":"HER2阳性胃癌","lang":"CN"}],[{"name":"Liver Injury","lang":"EN"},{"name":"肝损伤","lang":"CN"}],[{"name":"Locally Advanced Melanoma","lang":"EN"},{"name":"局部晚期黑色素瘤","lang":"CN"}],[{"name":"Metastatic Soft Tissue Sarcoma","lang":"EN"},{"name":"转移性软组织肉瘤","lang":"CN"}],[{"name":"Soft Tissue Sarcoma","lang":"EN"},{"name":"软组织肉瘤","lang":"CN"}],[{"name":"Unresectable Melanoma","lang":"EN"},{"name":"不可切除的黑色素瘤","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Phase 2 Clinical","first_approved_date":1640908800000,"first_approved_indication":[[{"name":"Hormone receptor positive HER2 negative breast cancer","lang":"EN"},{"name":"HR阳性/HER2阴性乳腺癌","lang":"CN"}]],"approval_country":["China"]}
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{"drug_name":[{"name":"盐酸芬戈莫德","lang":"CN"},{"name":"Fingolimod Hydrochloride","lang":"EN"},{"name":"フィンゴリモド塩酸塩","lang":"JP"}],"alias":[{"name":"FINGOLIMOD","lang":"EN"},{"name":"Fingolimod hydrochloride (JAN/USAN)","lang":"EN"},{"name":"Gilenia","lang":"EN"}],"target":[[{"name":"Sphingosine 1-phosphate receptor Edg-1","lang":"EN"},{"name":"鞘氨醇-1-磷酸受体-Edg-1","lang":"CN"}],[{"name":"Sphingosine 1-phosphate receptor Edg-3","lang":"EN"},{"name":"鞘氨醇-1-磷酸受体-Edg-3","lang":"CN"}],[{"name":"Sphingosine 1-phosphate receptor Edg-6","lang":"EN"},{"name":"鞘氨醇-1-磷酸受体-Edg-6","lang":"CN"}],[{"name":"Sphingosine 1-phosphate receptor Edg-8","lang":"EN"},{"name":"鞘氨醇-1-磷酸受体-Edg-8","lang":"CN"}]],"disease":[[{"name":"Multiple Sclerosis, Relapsing-Remitting","lang":"EN"},{"name":"复发-缓解型多发性硬化","lang":"CN"}],[{"name":"Multiple Sclerosis","lang":"EN"},{"name":"多发性硬化症","lang":"CN"}],[{"name":"Multiple sclerosis relapse","lang":"EN"},{"name":"复发性多发性硬化","lang":"CN"}],[{"name":"Acute Myeloid Leukemia","lang":"EN"},{"name":"急性髓性白血病","lang":"CN"}],[{"name":"Asthma","lang":"EN"},{"name":"哮喘","lang":"CN"}],[{"name":"Hepatitis C, Chronic","lang":"EN"},{"name":"慢性丙型肝炎","lang":"CN"}],[{"name":"Influenza, Human","lang":"EN"},{"name":"流感病毒感染","lang":"CN"}],[{"name":"Multifocal acquired demyelinating sensory and motor neuropathy","lang":"EN"},{"name":"多灶性获得性脱髓鞘性感觉和运动神经病","lang":"CN"}],[{"name":"Multiple Sclerosis, Primary Progressive","lang":"EN"},{"name":"原发性进行性多发性硬化","lang":"CN"}],[{"name":"Non-infectious posterior uveitis","lang":"EN"},{"name":"非感染性后葡萄膜炎","lang":"CN"}],[{"name":"Polyradiculoneuropathy, Chronic Inflammatory Demyelinating","lang":"EN"},{"name":"慢性炎症性脱髓鞘性多发性神经病","lang":"CN"}],[{"name":"Renal transplant rejection","lang":"EN"},{"name":"肾移植排斥反应","lang":"CN"}],[{"name":"Rett Syndrome","lang":"EN"},{"name":"Rett综合征","lang":"CN"}],[{"name":"Uveitis, Intermediate","lang":"EN"},{"name":"中间葡萄膜炎","lang":"CN"}]],"drug_type":["Small molecule drug"],"global_highest_dev_status":"Preclinical","first_approved_date":1285027200000,"first_approved_indication":[[{"name":"Multiple sclerosis relapse","lang":"EN"},{"name":"复发性多发性硬化","lang":"CN"}]],"approval_country":["United States","China","European Union","Japan","Australia","Iceland","South Korea","Liechtenstein","Norway"]}
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