pmid stringlengths 8 8 | text stringlengths 13.1k 59.8k | annotations listlengths 433 1.78k |
|---|---|---|
11319941 | Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number
Abstract
Background
The striatum plays a pivotal role in modulating motor activity and higher cognitive function. We analyzed variation in striatal volume and neuron number in mice and initiated a complex trait analysis ... | [
{
"offsets": [
[
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"text": [
"glutaraldehyde"
],
"db_name": "CHEBI",
"db_id": "CHEBI:64276"
},
{
"offsets": [
[
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],
"text": [
"cholinergic"
],
"db_name": "CHEBI",
"db... |
11604102 | Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL
Abstract
Background
DAZAP1 (DAZ Associated Protein 1) was originally identified by a yeast two-hybrid system through its interaction with a putative male infertility factor, DAZ (Deleted in ... | [
{
"offsets": [
[
10501,
10504
]
],
"text": [
"SDS"
],
"db_name": "CHEBI",
"db_id": "CHEBI:8984"
},
{
"offsets": [
[
11055,
11062
]
],
"text": [
"sucrose"
],
"db_name": "CHEBI",
"db_id": "CHEBI:179... |
14624252 | Additive Effects of PDGF Receptor β Signaling Pathways in Vascular Smooth Muscle Cell Development
Abstract
The platelet-derived growth factor β receptor (PDGFRβ) is known to activate many molecules involved in signal transduction and has been a paradigm for receptor tyrosine kinase signaling for many years. We have s... | [
{
"offsets": [
[
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"text": [
"effector"
],
"db_name": "CHEBI",
"db_id": "CHEBI:35224"
},
{
"offsets": [
[
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]
],
"text": [
"effector"
],
"db_name": "CHEBI",
"db_id": "CHEB... |
14675480 | Knockout of ERK5 causes multiple defects in placental and embryonic development
Abstract
Backgroud
ERK5 is a member of the mitogen activated protein kinase family activated by certain mitogenic or stressful stimuli in cells, but whose physiological role is largely unclear.
Results
To help determine the function of... | [
{
"offsets": [
[
187,
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]
],
"text": [
"mitogenic"
],
"db_name": "CHEBI",
"db_id": "CHEBI:52290"
},
{
"offsets": [
[
126,
133
]
],
"text": [
"mitogen"
],
"db_name": "CHEBI",
"db_id": "CHEBI:5229... |
14691534 | Pten Dose Dictates Cancer Progression in the Prostate
Abstract
Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the vast majority of CaPs at presentation. To determine the consequence of PTEN do... | [
{
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[
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"text": [
"phospho"
],
"db_name": "CHEBI",
"db_id": "CHEBI:32958"
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{
"offsets": [
[
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]
],
"text": [
"phosphatidylinositol 3,4,5-trisphosphate"
],
"db_nam... |
15018652 | Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice
Abstract
Background
In mice, germ cells are specified through signalling between layers of cells comprising the primitive embryo. The function of Dppa3 (also known as Pgc7 or stella), a gene expressed in primordial ger... | [
{
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[
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]
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"text": [
"molecules"
],
"db_name": "CHEBI",
"db_id": "CHEBI:36357"
},
{
"offsets": [
[
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]
],
"text": [
"hygromycin"
],
"db_name": "CHEBI",
"db_id": "CHE... |
15070402 | Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules
Abstract
Background
Opitz G/BBB syndrome is a genetic disorder characterized by developmental midline abnormalities, such as hypertelorism, cleft palate, an... | [
{
"offsets": [
[
872,
880
]
],
"text": [
"moieties"
],
"db_name": "CHEBI",
"db_id": "CHEBI:24433"
},
{
"offsets": [
[
37583,
37587
]
],
"text": [
"FITC"
],
"db_name": "CHEBI",
"db_id": "CHEBI:3792... |
15238161 | Hedgehog can drive terminal differentiation of amniote slow skeletal muscle
Abstract
Background
Secreted Hedgehog (Hh) signalling molecules have profound influences on many developing and regenerating tissues. Yet in most vertebrate tissues it is unclear which Hh-responses are the direct result of Hh action on a par... | [
{
"offsets": [
[
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],
"text": [
"biotin"
],
"db_name": "CHEBI",
"db_id": "CHEBI:15956"
},
{
"offsets": [
[
54554,
54560
]
],
"text": [
"biotin"
],
"db_name": "CHEBI",
"db_id": "CHEBI:... |
15328538 | Loss of Skeletal Muscle HIF-1α Results in Altered Exercise Endurance
Abstract
The physiological flux of oxygen is extreme in exercising skeletal muscle. Hypoxia is thus a critical parameter in muscle function, influencing production of ATP, utilization of energy-producing substrates, and manufacture of exhaustion-ind... | [
{
"offsets": [
[
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],
"text": [
"phosphoglucose"
],
"db_name": "CHEBI",
"db_id": "CHEBI:21008"
},
{
"offsets": [
[
17908,
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]
],
"text": [
"Electron"
],
"db_name": "CHEBI",
"db_id... |
15560850 | BAG-1 haplo-insufficiency impairs lung tumorigenesis
Abstract
Background
BAG-1 is a multifunctional co-chaperone of heat shock proteins (Hsc70/Hsp70) that is expressed in most cells. It interacts with Bcl-2 and Raf indicating that it might connect protein folding with other signaling pathways. Evidence that BAG-1 ex... | [
{
"offsets": [
[
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],
"text": [
"mitogenic"
],
"db_name": "CHEBI",
"db_id": "CHEBI:52290"
},
{
"offsets": [
[
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]
],
"text": [
"mitogenic"
],
"db_name": "CHEBI",
"db_id": "CHEB... |
15615595 | Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique
Abstract
Background
Congenital heart defects are the leading non-infectious cause of death in children. Genetic studies in the mouse have been crucial to uncover new genes and signaling pa... | [
{
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[
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"text": [
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],
"db_name": "CHEBI",
"db_id": "CHEBI:33252"
},
{
"offsets": [
[
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]
],
"text": [
"neomycin"
],
"db_name": "CHEBI",
"db_id": "CHEBI... |
15619330 | Dynamic in vivo imaging and cell tracking using a histone fluorescent protein fusion in mice
Abstract
Background
Advances in optical imaging modalities and the continued evolution of genetically-encoded fluorescent proteins are coming together to facilitate the study of cell behavior at high resolution in living org... | [
{
"offsets": [
[
50,
57
]
],
"text": [
"histone"
],
"db_name": "CHEBI",
"db_id": "CHEBI:15358"
},
{
"offsets": [
[
1282,
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]
],
"text": [
"photon"
],
"db_name": "CHEBI",
"db_id": "CHEBI:30212"
... |
15784609 | Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction
Abstract
Here we describe a triple transgenic mouse system, which combines the tissue specificity of any Cre-transgenic line with the inducibility of the reverse tetracycline t... | [
{
"offsets": [
[
5248,
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],
"text": [
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"db_name": "CHEBI",
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},
{
"offsets": [
[
5271,
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]
],
"text": [
"G418"
],
"db_name": "CHEBI",
"db_id": "CHEBI:42768... |
15850489 | GABAA receptor γ2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines
Abstract
Background
Gamma-aminobutyric acid type A receptors (GABAA-Rs) are the major inhibitory receptors in the mammalian brain and are modulated by a number of sedative/hypnotic drugs in... | [
{
"offsets": [
[
26513,
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"text": [
"formaldehyde"
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"db_name": "CHEBI",
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},
{
"offsets": [
[
26529,
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]
],
"text": [
"agarose"
],
"db_name": "CHEBI",
"db_id": ... |
15882093 | Neuronal Migration and Ventral Subtype Identity in the Telencephalon Depend on SOX1
Abstract
Little is known about the molecular mechanisms and intrinsic factors that are responsible for the emergence of neuronal subtype identity. Several transcription factors that are expressed mainly in precursors of the ventral te... | [
{
"offsets": [
[
7406,
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]
],
"text": [
"X-gal"
],
"db_name": "CHEBI",
"db_id": "CHEBI:75055"
},
{
"offsets": [
[
7859,
7864
]
],
"text": [
"X-gal"
],
"db_name": "CHEBI",
"db_id": "CHEBI:75055"... |
16026622 | Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice
Abstract
Background
Individuals may develop tolerance to the induction of adverse pulmonary effects following repeated exposures to inhaled toxicants. Previously, we demonstrated that genetic background plays an impor... | [
{
"offsets": [
[
243,
252
]
],
"text": [
"toxicants"
],
"db_name": "CHEBI",
"db_id": "CHEBI:64909"
},
{
"offsets": [
[
5487,
5491
]
],
"text": [
"chow"
],
"db_name": "CHEBI",
"db_id": "CHEBI:33290... |
16027110 | Identification and characterization of the mouse nuclear export factor (Nxf) family members
Abstract
TAP/hNXF1 is a key factor that mediates general cellular mRNA export from the nucleus, and its orthologs are structurally and functionally conserved from yeast to humans. Metazoans encode additional proteins that shar... | [
{
"offsets": [
[
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]
],
"text": [
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],
"db_name": "CHEBI",
"db_id": "CHEBI:22695"
},
{
"offsets": [
[
19671,
19676
]
],
"text": [
"basic"
],
"db_name": "CHEBI",
"db_id": "CHEBI:22... |
16410827 | The Notch Ligand JAG1 Is Required for Sensory Progenitor Development in the Mammalian Inner Ear
Abstract
In mammals, six separate sensory regions in the inner ear are essential for hearing and balance function. Each sensory region is made up of hair cells, which are the sensory cells, and their associated supporting ... | [
{
"offsets": [
[
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]
],
"text": [
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],
"db_name": "CHEBI",
"db_id": "CHEBI:22695"
},
{
"offsets": [
[
10418,
10426
]
],
"text": [
"neomycin"
],
"db_name": "CHEBI",
"db_id": "CHEBI:7... |
16517939 | An isoform of ZBP-89 predisposes the colon to colitis
Abstract
Alternative splicing enables expression of functionally diverse protein isoforms. The structural and functional complexity of zinc-finger transcription factor ZBP-89 suggests that it may be among the class of alternatively spliced genes. We identified a h... | [
{
"offsets": [
[
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]
],
"text": [
"basic"
],
"db_name": "CHEBI",
"db_id": "CHEBI:22695"
},
{
"offsets": [
[
26891,
26896
]
],
"text": [
"basic"
],
"db_name": "CHEBI",
"db_id": "CHEBI:22... |
16611361 | Generation of mice harbouring a conditional loss-of-function allele of Gata6
Abstract
The zinc finger transcription factor GATA6 is believed to have important roles in the development of several organs including the liver, gastrointestinal tract and heart. However, analyses of the contribution of GATA6 toward organog... | [
{
"offsets": [
[
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]
],
"text": [
"toxin"
],
"db_name": "CHEBI",
"db_id": "CHEBI:27026"
},
{
"offsets": [
[
13528,
13533
]
],
"text": [
"toxin"
],
"db_name": "CHEBI",
"db_id": "CHEBI:2702... |
16787536 | Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation
Abstract
Background
Cubilin is a peripheral membrane protein that interacts with the integral membrane proteins megalin and amnionless to mediate ligand endocytosis by absorptive epi... | [
{
"offsets": [
[
2079,
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]
],
"text": [
"cobalamin"
],
"db_name": "CHEBI",
"db_id": "CHEBI:30411"
},
{
"offsets": [
[
2090,
2093
]
],
"text": [
"Cbl"
],
"db_name": "CHEBI",
"db_id": "CHEBI:3041... |
16800892 | Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon
Abstract
Background
Insertional mutagenesis techniques with transposable elements have been popular among geneticists studying model organisms from E. coli to Drosophila and, more recently, the mouse. One such element is the Sleepi... | [
{
"offsets": [
[
4574,
4586
]
],
"text": [
"tetracycline"
],
"db_name": "CHEBI",
"db_id": "CHEBI:27902"
},
{
"offsets": [
[
4623,
4626
]
],
"text": [
"Tet"
],
"db_name": "CHEBI",
"db_id": "CHEBI:2... |
16968134 | Inhibition of Gap Junction Communication at Ectopic Eph/ephrin Boundaries Underlies Craniofrontonasal Syndrome
Abstract
Mutations in X-linked ephrin-B1 in humans cause craniofrontonasal syndrome (CFNS), a disease that affects female patients more severely than males. Sorting of ephrin-B1–positive and –negative cells ... | [
{
"offsets": [
[
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]
],
"text": [
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],
"db_name": "CHEBI",
"db_id": "CHEBI:15358"
},
{
"offsets": [
[
18006,
18009
]
],
"text": [
"dye"
],
"db_name": "CHEBI",
"db_id": "CHEBI:3795... |
17029558 | Mutation at the Evi1 Locus in Junbo Mice Causes Susceptibility to Otitis Media
Abstract
Otitis media (OM), inflammation of the middle ear, remains the most common cause of hearing impairment in children. It is also the most common cause of surgery in children in the developed world. There is evidence from studies of ... | [
{
"offsets": [
[
520,
541
]
],
"text": [
"N-ethyl-N-nitrosourea"
],
"db_name": "CHEBI",
"db_id": "CHEBI:23995"
},
{
"offsets": [
[
4449,
4452
]
],
"text": [
"ENU"
],
"db_name": "CHEBI",
"db_id": "... |
17201918 | SirT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
Abstract
Introduction
Estrogen and insulin-like growth factor-1 (IGF-1) play important roles in mammary gland development and breast cancer. SirT1 is a highly conserved protein deacetylase that can ... | [
{
"offsets": [
[
4398,
4402
]
],
"text": [
"food"
],
"db_name": "CHEBI",
"db_id": "CHEBI:33290"
},
{
"offsets": [
[
4519,
4535
]
],
"text": [
"steroid hormones"
],
"db_name": "CHEBI",
"db_id": "CH... |
17206865 | A Role for Alström Syndrome Protein, Alms1, in Kidney Ciliogenesis and Cellular Quiescence
Abstract
Premature truncation alleles in the ALMS1 gene are a frequent cause of human Alström syndrome. Alström syndrome is a rare disorder characterized by early obesity and sensory impairment, symptoms shared with other gene... | [
{
"offsets": [
[
7357,
7366
]
],
"text": [
"molecules"
],
"db_name": "CHEBI",
"db_id": "CHEBI:36357"
},
{
"offsets": [
[
30681,
30685
]
],
"text": [
"Ca2+"
],
"db_name": "CHEBI",
"db_id": "CHEBI:2... |
17465682 | PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism
Abstract
Peroxisome proliferator activated receptor gamma 2 (PPARg2) is the nutritionally regulated isoform of PPARg. Ablation of PPARg2 in the ob/ob background, PPARg2−/− Lepob/Lepob (POKO mouse), resulted ... | [
{
"offsets": [
[
41232,
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]
],
"text": [
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],
"db_name": "CHEBI",
"db_id": "CHEBI:8984"
},
{
"offsets": [
[
33278,
33283
]
],
"text": [
"lipid"
],
"db_name": "CHEBI",
"db_id": "CHEBI:18059... |
17503968 | A KATP Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans
Abstract
Glucagon, secreted from pancreatic islet α cells, stimulates gluconeogenesis and liver glycogen breakdown. The mechanism regulating glucagon release is debated, and variously attributed... | [
{
"offsets": [
[
552,
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]
],
"text": [
"Glucose"
],
"db_name": "CHEBI",
"db_id": "CHEBI:17234"
},
{
"offsets": [
[
1054,
1061
]
],
"text": [
"glucose"
],
"db_name": "CHEBI",
"db_id": "CHEBI:1723... |
17565376 | CARD15/NOD2 Is Required for Peyer's Patches Homeostasis in Mice
Abstract
Background
CARD15/NOD2 mutations are associated with susceptibility to Crohn's Disease (CD) and Graft Versus Host Disease (GVHD). CD and GVHD are suspected to be related with the dysfunction of Peyer's patches (PP) and isolated lymphoid follicl... | [
{
"offsets": [
[
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]
],
"text": [
"food"
],
"db_name": "CHEBI",
"db_id": "CHEBI:33290"
},
{
"offsets": [
[
24442,
24456
]
],
"text": [
"methylene blue"
],
"db_name": "CHEBI",
"db_id": "... |
17677002 | Complex Seizure Disorder Caused by Brunol4 Deficiency in Mice
Abstract
Idiopathic epilepsy is a common human disorder with a strong genetic component, usually exhibiting complex inheritance. We describe a new mouse mutation in C57BL/6J mice, called frequent-flyer (Ff), in which disruption of the gene encoding RNA-bin... | [
{
"offsets": [
[
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]
],
"text": [
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"db_name": "CHEBI",
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},
{
"offsets": [
[
8470,
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]
],
"text": [
"Prozac"
],
"db_name": "CHEBI",
"db_id": "CHEBI:5118"
... |
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