table,column,type,non_null_count,unique_value_count,sample_values,table_description
ago1_lnp_aso_endothelial_liver_vascular_context.csv,oligo_id,string,4,4,OLIGO_CTRL_NEG_LNP_AGO1_ASO_ALT_AST_STAB | OLIGO_CTRL_CONTEXT_ENDOTHELIAL_AGO1_NFKB | OLIGO_CTRL_CONTEXT_LNP_ASO_HYPERLIPIDEMI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,source_id,categorical,4,1,LIU_ENDOTHELIAL_AGO1_LNP_ASO_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,control_id,string,4,4,CTRL_NEG_LNP_AGO1_ASO_ALT_AST_STABLE | CTRL_CONTEXT_ENDOTHELIAL_AGO1_NFKB_INFLA | CTRL_CONTEXT_LNP_ASO_HYPERLIPIDEMIA_LIVE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,target_gene,string,4,3,AGO1 | AGO1_NFKB_context | AGO1_paracrine_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,modality,string,4,3,LNP-delivered LNA gapmer ASO | LNA gapmer ASO mechanism context | LNA gapmer ASO cell-interaction context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,sequence_length,integer,4,1,16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,gc_content,float,4,3,0.5 | 0.4375 | 0.5625,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,dose,integer,4,2,1.0 | 10.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,hepatotox_score,float,4,4,1.6 | 3.8 | 2.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,hepatotoxicity_label,categorical,4,1,low,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,value_origin,categorical,4,1,literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,assumption_id,categorical,4,1,ASM_039,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,ago1_lnp_aso_context,string,4,4,LNP_AGO1_ASO_low_hepatic_injury | endothelial_AGO1_NFKB_p65_inflammation | AAV9_PCSK9_HFHCD_liver_vascular_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,preprint_caution_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,LNP_formulation_flag,integer,4,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,LNA_gapmer_ASO_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,target_gene_context,categorical,4,1,AGO1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,primary_cell_context,categorical,4,1,endothelial_cell_or_liver_sinusoidal_end,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,disease_model_context,categorical,4,1,AAV9_PCSK9_high_fat_high_cholesterol_ath,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,AGO1_mRNA_knockdown_fraction_proxy,float,4,4,0.75 | 0.58 | 0.62,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,AGO1_ASO_dose_mg_kg_proxy,integer,4,2,1.0 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,NFkB_p65_coactivation_score_proxy,float,4,4,0.051 | 0.046 | 0.156,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,ICAM1_reduction_score_proxy,float,4,4,0.817 | 0.689 | 0.703,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,VCAM1_reduction_score_proxy,float,4,4,0.772 | 0.704 | 0.611,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,CCL2_reduction_score_proxy,float,4,4,0.766 | 0.684 | 0.596,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,THBS1_reduction_score_proxy,float,4,4,0.81 | 0.736 | 0.579,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,monocyte_adhesion_reduction_score_proxy,float,4,4,0.711 | 0.668 | 0.652,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,EC_hepatocyte_paracrine_context_flag,integer,4,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,lipid_profile_improvement_score_proxy,float,4,4,0.82 | 0.25 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,LDL_VLDL_reduction_score_proxy,float,4,4,0.861 | 0.22 | 0.743,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,HDL_ratio_improvement_score_proxy,float,4,4,0.707 | 0.452 | 0.568,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,hepatic_steatosis_reduction_score_proxy,float,4,4,0.597 | 0.23 | 0.666,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,hepatic_macrophage_infiltration_reduction_score_proxy,float,4,4,0.671 | 0.604 | 0.597,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,hepatic_fibrosis_reduction_score_proxy,float,4,4,0.498 | 0.406 | 0.531,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,atherosclerotic_plaque_reduction_score_proxy,float,4,4,0.775 | 0.541 | 0.742,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,ALT_fold_change_proxy,float,4,3,0.95 | 1.0 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,AST_fold_change_proxy,float,4,3,0.96 | 1.0 | 0.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,no_evident_hepatotoxicity_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,ALT_AST_safety_monitoring_score_proxy,integer,4,1,1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,direct_oligotox_relevance_modifier,float,4,1,0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,delivery_translatability_score_proxy,float,4,2,0.9 | 0.64,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,phase2_controls_relevance_score,float,4,1,0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,phase2_translatability_relevance_score,float,4,1,0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,ago1_lnp_aso_context_confidence_score,float,4,1,0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ago1_lnp_aso_endothelial_liver_vascular_context.csv,supporting_hepatotoxicity_class_proxy,string,4,4,negative_control_low_ALT_AST | mechanism_context | disease_model_safety_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,agt_knockdown_fraction_proxy,float,80,79,0.81166 | 0.95 | 0.79169,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,alt_fold_uln_proxy,float,80,80,1.27272 | 1.55479 | 3.57951,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,antisense_5prime_vinylphosphonate,integer,80,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,ast_fold_uln_proxy,float,80,78,1.18919 | 1.41634 | 3.13879,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,candidate_class,categorical,80,4,potent_safe_candidate | screened_candidate | toxic_offtarget_candidate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,duration_of_effect_days_proxy,float,80,80,171.76849 | 163.52268 | 64.96638,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,galnac_conjugated,integer,80,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,hepg2_ic50_pM_proxy,float,80,80,2.16816 | 15.56973 | 13.13051,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,histopathology_kidney_damage_score_proxy,float,80,71,0.06869 | 0.24681 | 0.38247,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,histopathology_liver_damage_score_proxy,float,80,72,0.08334 | 0.34752 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,huh7_ic50_pM_proxy,float,80,80,2.27624 | 15.80328 | 3.23476,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,judging_alignment,categorical,80,1,Ability_to_Solve_Challenge|Feasibility_a,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,modality,categorical,80,1,chemically_modified_GalNAc_AGT_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,modeling_value,categorical,80,1,direct_predictor_and_safety_label_module,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,modification_pattern_family,categorical,80,4,AL_alternating_2F_2MOE | DV29PG5_like | DV_reduced_2F_rearranged,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,module_record_id,identifier,80,80,AGT_SIRNA_TOX_0001 | AGT_SIRNA_TOX_0002 | AGT_SIRNA_TOX_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,oligo_id,string,80,80,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,predicted_offtarget_gene_count_proxy,integer,80,55,31 | 63 | 106,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,ps_linkage_count_proxy,integer,80,12,7 | 4 | 6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,rnaseq_dose_dependent_downregulated_gene_count_proxy,integer,80,57,16 | 86 | 254,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,safety_class_generated,categorical,80,4,favorable | screening_required | toxicity_signal,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,source_id,categorical,80,1,HUANG_AGT_GALNAC_SIRNA_TOXICOLOGY_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,target_gene,categorical,80,1,AGT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,two_prime_F_fraction_proxy,float,80,80,0.26653 | 0.30695 | 0.19715,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,two_prime_MOE_fraction_proxy,float,80,80,0.34198 | 0.41723 | 0.34811,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,urea_fold_baseline_proxy,float,80,80,1.16478 | 1.48813 | 1.30616,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
agt_galnac_sirna_development_toxicology.csv,value_origin,categorical,80,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,angptl3_context_id,string,1120,1120,ANGPTL3_CTRL_OLIGO_NEG_VEHICLE_MOCK | ANGPTL3_CTRL_OLIGO_NEG_LOW_RISK | ANGPTL3_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,angptl3_platform_context,categorical,1120,4,not_ANGPTL3_targeted | GalNAc_siRNA_ARO_ANG3_like | GalNAc_ASO_vupanorsen_like,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,angptl3_liver_safety_state,categorical,1120,5,baseline_non_ANGPTL3 | ANGPTL3_siRNA_moderate_inhibition_liver_ | ANGPTL3_ASO_high_inhibition_hepatic_fat_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,angptl3_target_inhibition_pct_proxy,float,1120,32,0.0 | 78.0 | 94.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,angptl3_hepatic_fat_change_pct_proxy,float,1120,42,0.0 | -28.0 | 72.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,angptl3_alt_ast_gt3x_uln_probability_proxy,float,1120,29,0.0 | 0.01 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,angptl3_transaminase_signal_fold_ULN_proxy,float,1120,42,1.0 | 1.05 | 3.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,angptl3_liver_safety_stress_modifier,float,1120,42,0.0 | 0.10986 | 1.6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,angptl3_liver_safety_protective_modifier,float,1120,26,0.0 | 0.9 | 0.33212,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,context_note,categorical,1120,2,platform-specific ANGPTL3 liver-safety p | platform-specific ANGPTL3 liver-safety c,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
angptl3_liver_safety.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,PK_PD_utility,string,5,5,supports_PK_PD_biodistribution | supports_extrahepatic_tissue_distributio | supports_systemic_PK,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,active_payload,categorical,5,1,free_unconjugated_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,analytical_platform,categorical,5,1,hybridization_LC-MS/MS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,capture_strategy,categorical,5,1,biotinylated_complementary_probe_hybridi,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,challenge_alignment,categorical,5,1,"supports feasibility, rigor, transparenc",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,conjugate_or_payload_context,string,5,4,Fab-ASO | antibody-ASO_or_Fab-ASO | intact_AOC_plus_ASO_linker,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,free_ASO_recovery_proxy,float,5,5,0.82 | 0.76 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,matrix,string,5,4,liver | gastrocnemius | plasma_or_serum,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,method_specificity_score_proxy,float,5,5,0.91 | 0.88 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,module_id,categorical,5,1,AOC_free_ASO_payload_bioanalysis,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,notes,categorical,5,1,Generated measurement-quality row; no pr,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,parent_or_linker_interference_risk,string,5,5,low | low_to_moderate | moderate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,provenance_label,categorical,5,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,sample_preparation_logic,string,5,4,removed_to_avoid_artifactual_conversion | method_dependent | removed_or_minimized,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,scenario_id,string,5,5,liver_free_ASO_payload | gastrocnemius_free_ASO_payload | plasma_serum_free_ASO_payload,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,source_id,categorical,5,1,JIANG_AOC_FREE_ASO_PAYLOAD_HYBRIDIZATION,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aoc_free_aso_payload_bioanalysis.csv,value_origin,categorical,5,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,ago2_loading_score_proxy,float,160,160,0.54062 | 0.63207 | 0.64345,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,alt_fold_uln_proxy,float,160,159,1.12338 | 0.99955 | 0.95159,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,apoc3_mrna_reduction_fraction_proxy,float,160,160,0.46835 | 0.54975 | 0.6303,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,candidate_scaffold_class,categorical,160,5,standard_clinical_surrogate | reduced_2F_long_acting_lead | high_2F_potent_shorter,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,delivery_ligand,categorical,160,1,triantennary_GalNAc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,dosing_interval_burden_score_proxy,float,160,156,0.17618 | 0.29272 | 0.2916,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,duration_index_proxy,float,160,156,0.82382 | 0.70728 | 0.7084,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,judging_alignment,categorical,160,1,Ability_to_Solve_Challenge|Potential_Imp,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,modeling_value,categorical,160,1,direct_GalNAc_siRNA_SAR_duration_safety_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,module_record_id,string,160,160,APOC3_SIRNA_0001 | APOC3_SIRNA_0002 | APOC3_SIRNA_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,ps_terminal_linkage_count_proxy,integer,160,9,4 | 3 | 2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,route,categorical,160,1,subcutaneous_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,safety_class_generated,categorical,160,3,favorable_long_acting | intermediate | selectivity_or_tolerability_concern,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,selectivity_offtarget_count_proxy,integer,160,66,21 | 15 | 36,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,source_id,categorical,160,1,PRAKASH_APOC3_LONG_ACTING_GALNAC_SIRNA_2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,species_or_system,categorical,160,4,human_hepatocyte_cell | huAPOC3_mouse | CD1_tolerability_mouse,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,target,categorical,160,1,APOC3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,tolerability_score_proxy,float,160,155,0.87779 | 0.85338 | 0.79009,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,triglyceride_reduction_fraction_proxy,float,160,159,0.54846 | 0.53884 | 0.6399,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,two_prime_F_fraction_proxy,float,160,160,0.39493 | 0.41112 | 0.40711,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,two_prime_OMe_MOE_fraction_proxy,float,160,158,0.50881 | 0.52948 | 0.52038,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
apoc3_galnac_sirna_sar_safety.csv,value_origin,categorical,160,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
approved_oligo_chemistry_landscape.csv,assumption_id,categorical,7,1,ASM_125,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
approved_oligo_chemistry_landscape.csv,chemistry_or_delivery_feature,string,7,7,phosphorothioate_backbone | 2prime_F_RNA | 2prime_OMe_RNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
approved_oligo_chemistry_landscape.csv,clinical_maturity_score_proxy,float,7,7,0.88 | 0.8 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
approved_oligo_chemistry_landscape.csv,dataset_context,string,7,7,broad_ASO_distribution_context | approved_siRNA_chemistry_context | common_approved_siRNA_modification,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
approved_oligo_chemistry_landscape.csv,delivery_specificity_score_proxy,float,7,7,0.8 | 0.74 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
approved_oligo_chemistry_landscape.csv,functional_interpretation,string,7,7,nuclease_resistance_and_protein_binding | stability_potency_modification | stability_and_immunostimulation_mitigati,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
approved_oligo_chemistry_landscape.csv,generic_safety_complexity_score_proxy,float,7,6,0.7 | 0.58 | 0.54,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
approved_oligo_chemistry_landscape.csv,module_id,categorical,7,1,approved_oligonucleotide_chemistry_deliv,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
approved_oligo_chemistry_landscape.csv,notes,categorical,7,1,Reference row used to standardize chemis,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
approved_oligo_chemistry_landscape.csv,primary_modality_context,string,7,5,ASO_gapmer_SSO | siRNA_aptamer | splice_switching_oligo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
approved_oligo_chemistry_landscape.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
approved_oligo_chemistry_landscape.csv,source_id,categorical,7,1,EGLI_MANOHARAN_APPROVED_OLIGO_CHEMISTRY_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
approved_oligo_chemistry_landscape.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,oligo_id,identifier,43,43,OLIGO_0000019 | OLIGO_0000043 | OLIGO_0000133,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,source_id,string,43,28,MA_HSD17B13_ASO_FIBROSIS_MOUSE_2024 | QU_CPG_ODN_APAP_TLR9_IRG1_2025 | JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,control_id,categorical,43,12,NON_CONTROL_GENERATED_RECORD | CTRL_POS_SEQUENCE_MOTIF_GAPMER_LIVER_RIS | CTRL_POS_LNA_GAPMER_HIGH_OTE_ALT_AST,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,target_gene,string,43,29,CYP2E1 | ANGPTL8 | PNPLA3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,modality,categorical,43,7,scpBNA2_gapmer_ASO | LNA_cEt_PS_gapmer_ASO | LNA gapmer ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,sequence_length,integer,43,11,23 | 21 | 22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,gc_content,float,43,32,0.5217391304347826 | 0.3333333333333333 | 0.4545454545454545,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,seed_region,string,11,11,CGCGUUG | CUAUCUU | ACGUAAA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,hepatotox_score,float,43,43,5.17518697853974 | 3.788891218794384 | 8.08105735589514,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,hepatotoxicity_label,categorical,43,3,moderate | low | high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,value_origin,categorical,43,2,literature_grounded_generated | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,assumption_id,categorical,43,8,ASM_002 | ASM_041 | ASM_043,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,aso_gapmer_screen_state,categorical,43,2,generated_background | encoded,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,lna_gapmer_screen_context_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,rnase_h1_gapmer_context_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,fully_phosphorothioated_gapmer_context_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,gapmer_length_nt_proxy,integer,43,3,14 | 16 | 15,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,acute_mouse_screen_days_proxy,integer,43,1,3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,acute_mouse_screen_dose_mg_kg_proxy,integer,43,2,100.0 | 30.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,repeat_dose_mouse_days_proxy,integer,43,1,15,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,repeat_dose_rank_concordance_score_proxy,float,43,39,0.735 | 0.722 | 0.753,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,plasma_ALT_fold_vs_control_proxy,float,43,43,7.452 | 4.395 | 6.944,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,plasma_AST_fold_vs_control_proxy,float,43,43,4.238 | 2.292 | 4.182,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,ALT_AST_average_fold_proxy,float,43,43,5.845 | 3.344 | 5.563,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,liver_weight_fold_vs_control_proxy,float,43,40,1.335 | 1.154 | 1.293,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,predicted_offtarget_hit_count_proxy,integer,43,43,286 | 75 | 463,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,potent_offtarget_effect_count_proxy,integer,43,24,37 | 9 | 25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,transcriptome_selectivity_score_proxy,float,43,42,0.617 | 0.776 | 0.648,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,mouse_human_OTE_concordance_score_proxy,float,43,37,0.779 | 0.91 | 0.743,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,in_silico_OTE_prediction_required_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,transcriptome_wide_selectivity_screen_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,ALT_AST_liver_weight_streamlined_endpoint_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,positive_negative_control_applicable_flag,integer,43,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,hepatotoxicity_screen_rank_label,categorical,43,6,high_OTE_hepatotoxicity_like | intermediate_screen_signal | high_OTE_high_ALT_AST_positive_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,screening_hepatotoxicity_class_proxy,categorical,43,4,high | moderate | low,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,screening_recommendation,categorical,43,5,deselect_or_redesign | redesign_or_follow_with_RNAseq_selectivi | progress_with_standard_safety_followup,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,phase2_experimental_design_relevance_score,float,43,2,0.67 | 0.94,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,phase2_translatability_relevance_score,float,43,2,0.62 | 0.91,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,phase2_controls_relevance_score,float,43,2,0.7 | 0.95,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_gapmer_hepatotoxicity_screening.csv,aso_gapmer_screen_context_confidence_score,float,43,2,0.55 | 0.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,PS_protein_binding_stress_score_proxy,float,6,6,0.7 | 0.15 | 0.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,assumption_id,categorical,6,1,ASM_081,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,challenge_alignment,categorical,6,1,supports feasibility and rigor by encodi,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,chemical_modification_context,string,6,6,none | clinical_like_reference | 2prime-OMe_gap_position_2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,late_onset_neurotoxicity_score_proxy,float,6,6,0.82 | 0.12 | 0.38,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,liver_oligotox_relevance,categorical,6,1,cross_organ_ASO_toxicity_and_chemistry_m,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,model_system,string,6,5,mouse_i_c_v_or_rat_i_t | CNS_reference | in_vitro_and_in_vivo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,modeling_role,string,6,6,toxic_parent_reference | non_toxic_reference | toxicity_reduction_candidate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,module_id,categorical,6,1,ASO_late_onset_neurotoxicity_chemical_mo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,notes,categorical,6,1,Generated cross-organ toxicity scenario ,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,oligo_modality,categorical,6,1,gapmer_PS_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,p53_regulated_transcript_stress_score_proxy,float,6,6,0.78 | 0.18 | 0.35,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,paraspeckle_p54nrb_mislocalization_score_proxy,float,6,6,0.75 | 0.16 | 0.32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,scenario_id,string,6,6,parent_gapmer_ASO_late_toxic | non_toxic_reference_ASO5 | 2prime_OMe_position_2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,source_id,categorical,6,1,KURODA_ASO_LATE_ONSET_NEUROTOX_5CP_MODIF,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,target_knockdown_preservation_score_proxy,float,6,6,0.35 | 0.6 | 0.55,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_late_onset_neurotox_chemical_modifications.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_metabolic_context_id,string,1120,1120,ASONAFLD_CTRL_OLIGO_NEG_VEHICLE_MOCK | ASONAFLD_CTRL_OLIGO_NEG_LOW_RISK | ASONAFLD_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_metabolic_nafld_state,categorical,1120,7,baseline_non_ASO_metabolic_context | GalNAc_ASO_hepatocyte_targeted_metabolic | high_affinity_gapmer_hepatotoxic_sequenc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_metabolic_target_class,categorical,1120,6,not_applicable | lipid_partitioning_or_DNL | DNL_or_lipid_target_with_injury_risk,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_RNase_H1_gapmer_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_GalNAc_hepatocyte_targeting_multiplier_proxy,integer,1120,2,1.0 | 10.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_predicted_steatosis_change_proxy,float,1120,119,0.0 | -0.42 | -0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_insulin_sensitivity_improvement_proxy,float,1120,119,0.0 | 0.26 | 0.05,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_DNL_pathway_suppression_proxy,float,1120,119,0.0 | -0.36 | -0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_metabolic_benefit_score,float,1120,117,0.0 | 0.78 | 0.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_hepatic_injury_challenge_score,float,1120,119,0.0 | 0.08 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_ALT_AST_monitoring_fold_proxy,float,1120,119,1.0 | 1.05 | 3.6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_GGT_monitoring_fold_proxy,float,1120,119,1.0 | 1.02 | 2.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_sequence_motif_toxicity_context,categorical,1120,5,not_applicable | none_detected | TCC,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_sequence_motif_risk_score,float,1120,107,0.0 | 0.05 | 0.92,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_type_I_interferon_response_proxy,float,1120,104,0.0 | 0.04 | 0.28,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_kidney_injury_monitoring_proxy,float,1120,100,0.0 | 0.05 | 0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_tissue_distribution_context,categorical,1120,3,not_applicable | hepatocyte_targeted_GalNAc | broad_ASO_distribution,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_hepatic_injury_modifier,float,1120,118,0.0 | 1.1072 | 0.52,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_metabolic_benefit_modifier,float,1120,117,0.0 | 0.78 | 0.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,aso_metabolic_safety_label,categorical,1120,4,ASO_context_intermediate | ASO_metabolic_benefit_low_injury | ASO_safety_challenge,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,context_note,categorical,1120,2,ASO metabolic/NAFLD benefit and safety-c | ASO metabolic/NAFLD context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_metabolic_nafld_context.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,HepG2_apoptosis_or_cell_stress_score_proxy,float,36,34,0.009 | 0.016 | 0.019,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,aso_profile_id,categorical,36,6,vehicle_PBS | 569713 | LNA32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,challenge_alignment,categorical,36,1,directly supports feasibility/rigor by m,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,chemistry_design,categorical,36,3,vehicle | LNA_3-10-3_PS_gapmer | LNA_3-8-3_PS_gapmer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,intended_on_target_transcript,categorical,36,5,none | none_control_ASO | mMYD88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,modeling_role,categorical,36,5,baseline_control | non_toxic_ASO_control | non_toxic_targeting_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,module_id,categorical,36,1,ASO_time_resolved_multiomics_safety,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,mouse_ALT_IU_per_L_proxy,integer,36,4,31 | 29 | 159,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,notes,categorical,36,1,Generated time-course row; proxy values ,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,pathway_perturbation_score_proxy,float,36,36,0.012 | 0.021 | 0.026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,protein_level_offtarget_burden_score_proxy,float,36,36,0.009 | 0.016 | 0.019,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,proteomics_de_risking_relevance,categorical,36,2,moderate_or_low | high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,provenance_label,categorical,36,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,rna_level_offtarget_burden_score_proxy,float,36,36,0.016 | 0.027 | 0.032,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,rna_protein_offtarget_discordance_score_proxy,float,36,34,0.006 | 0.011 | 0.013,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,safety_assessment_layer,categorical,36,1,RNAseq|global_proteomics|qPCR|western_bl,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,source_id,categorical,36,1,VAN_LEEUWEN_ASO_MULTIOMICS_TIME_RESOLVED,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,timepoint_hours,integer,36,6,8 | 24 | 32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,toxicity_class,categorical,36,4,non_toxic_reference | non_toxic | medium_liver_toxic,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
aso_multiomics_time_resolved_safety.csv,value_origin,categorical,36,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
assays.csv,assay_id,string,5600,5600,ASSAY_CTRL_OLIGO_NEG_VEHICLE_MOCK_T24 | ASSAY_CTRL_OLIGO_NEG_VEHICLE_MOCK_T72 | ASSAY_CTRL_OLIGO_NEG_VEHICLE_MOCK_T168,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assays.csv,oligo_id,string,5600,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assays.csv,source_id,string,5600,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assays.csv,control_id,string,5600,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assays.csv,model_system,categorical,5600,3,in_vitro_liver_model | clinical_proxy | animal_cell_model,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assays.csv,cell_model,string,5600,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assays.csv,human_in_vitro_or_clinical_proxy,integer,5600,2,1 | 0,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assays.csv,species,categorical,5600,3,human | mouse | rat,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assays.csv,organoid_or_MPS,integer,5600,2,0 | 1,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assays.csv,assay_type,categorical,5600,1,hepatotoxicity_readout_panel,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assays.csv,time_hours,integer,5600,5,24 | 72 | 168,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assays.csv,replicate_count,integer,5600,1,3,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assays.csv,record_origin,categorical,5600,1,dbbun_generated,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assays.csv,value_origin,categorical,5600,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Assay metadata: model system, cell model, species/human-proxy flag, organoid/MPS status, replicate count, time points, assay type."
assumptions.csv,assumption_id,identifier,76,76,ASM_001 | ASM_002 | ASM_003,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,assumption_category,string,58,58,synthetic_data_scope | predictor_framework | PS_content,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,assumption_text,string,62,62,"Generated records are not measured exper | Sequence-derived, chemistry-derived, bio | Higher phosphorothioate content increase",Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,impact,string,54,46,Prevents overclaiming and preserves tran | Defines the multivariable risk score and | Affects chemical modification table and ,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,confidence,categorical,52,8,high | medium_high | medium,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,record_origin,categorical,76,1,method_assumption,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,source_basis,string,5,5,RAPIROSIRAN_SANYAL_2025 | DUDZICZ_ZILEBESIRAN_HTN_REVIEW_2025 | HAUPTMANN_SIRNA_BULGES_GALNAC_2022,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,impact_on_generation,string,8,8,"Adds AGT/RAAS clinical-platform variable | Adds bulge length, position, region, gui | Adds FBLL1 expression, malignant-hepatoc",Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,assumption_label,string,1,1,OGT_sEV_LSEC_capillarization_MASLD_conte,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,description,string,14,14,"Lipotoxic hepatocyte-derived sEVs can be | HBx-induced MALAT1, m6A modification, IG | CD133-positive cancer stem cell enrichme",Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,applies_to,string,1,1,ogt_sev_lsec_masld_context.csv,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,risk_if_wrong,string,1,1,Could overstate relevance of extracellul,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,mitigation,string,1,1,"Label as supporting context only, keep v",Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,assumption_type,string,4,4,supporting_HBV_HCC_ASO_MALAT1_context | supporting_MASLD_HCC_CD133_siRNA_combina | supporting_GalNAc_RBC_EV_hepatocyte_deli,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,source_id,string,8,8,DU_MALAT1_HBV_HCC_ASO_2025 | PAN_CD133_MASLD_HCC_SIRNA_2025 | HUANG_GALNAC_RBC_EV_LIVER_DISEASE_2025,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,assumption_name,string,8,8,ALD_ALDH2_Nrf2_oxidative_stress_context | calcium_phosphate_hybrid_nanoparticle_si | PMEVL_sEV_small_RNA_loading_hepatic_siRN,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,source_ids,string,4,4,MA_FORMONONETIN_ALDH2_ALD_2025 | VALLE_HOXB7_HNP_TAMOXIFEN_BREAST_2024 | WANG_PMEVL_SEV_SMALL_RNA_PCSK9_2026,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,expected_use,string,4,4,supporting_liver_context_not_direct_olig | supporting_delivery_platform_safety_cont | supporting_sEV_RNA_delivery_and_hepatic_,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,evidence_source_id,identifier,23,23,BI_IFNA_DISULFIDPTOSIS_HCC_2026 | JANAS_GALNAC_RNAI_NONCLINICAL_SAFETY_201 | BOSCO_INCLISIRAN_FH_REALWORLD_2025,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,rationale,string,5,5,The source paper reports that a 3-day ac | The source preprint reports LNP-delivere | The GYS1 Pompe preprint reports a system,Explicit list of biological and modeling assumptions used in dataset generation.
assumptions.csv,generated_variables,string,4,4,"HSC activation, collagen translation/exp | Reversible silencing, induction, shRNA/s | RISC loading, 5-prime capping rescue, se",Explicit list of biological and modeling assumptions used in dataset generation.
bepirovirsen_immunomodulation_alt.csv,ALT_increase_association_score_proxy,float,6,6,0.05 | 0.18 | 0.25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,HBsAg_decline_response_score_proxy,float,6,6,0.05 | 0.21 | 0.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,apoptosis_liver_specific_protein_score_proxy,float,6,6,0.08 | 0.34 | 0.39,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,challenge_alignment,categorical,6,1,"directly strengthens Ability-to-Solve, P",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,clinical_biomarker_layers,categorical,6,1,serum_proteomics|whole_blood_transcripto,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,direct_antiviral_HBV_RNA_targeting,categorical,6,1,yes_all_HBV_RNAs,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,disease_context,categorical,6,1,chronic_HBV_on_stable_nucleoside_analog_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,immune_cell_transcript_activation_score_proxy,float,6,6,0.1 | 0.46 | 0.64,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,immune_effector_activation_score_proxy,float,6,6,0.12 | 0.72 | 0.66,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,module_id,categorical,6,1,bepirovirsen_ASO_immunomodulation_ALT_co,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,notes,categorical,6,1,Generated clinical-biomarker scenario ro,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,oligo_modality,categorical,6,1,unconjugated_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,scenario_id,string,6,6,baseline_NA_background | week3_effector_apoptotic_serum_proteins | week5_immune_cell_activation_transcripts,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,source_id,categorical,6,1,JOSHI_BEPIROVIRSEN_B_TOGETHER_IMMUNOMODU,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,therapeutic_ALT_interpretation,categorical,6,2,low_or_baseline_ALT_context | possible_infected_hepatocyte_killing_sig,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,time_context,string,6,6,pre_dose | week_3 | week_5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
bepirovirsen_immunomodulation_alt.csv,week_on_bepirovirsen_proxy,integer,6,4,0 | 3 | 5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,assumption_id,categorical,7,1,ASM_103,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,challenge_alignment,categorical,7,1,"supporting module for oligo modality, de",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,delivery_or_targeting_score_proxy,float,7,6,0.58 | 0.74 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,mechanism_or_specificity_score_proxy,float,7,7,0.62 | 0.78 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,modality_or_platform,string,7,4,EMNV | hybrid_EMNV_liposome | EMNV_surface_engineering,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,model_system,string,7,6,cell_derived_nanovesicles | extruded_Hyb_nanoparticles | HepG2_and_mouse_cell_lines,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,modeling_role,string,7,7,biological_nanoparticle_baseline | RNA_loading_and_fusion_context | intracellular_RNA_delivery_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,module_id,categorical,7,1,biologics_Hyb_EMNV_liposome_RNA_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,notes,categorical,7,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,primary_effect_score_proxy,float,7,6,0.64 | 0.86 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,scenario_id,string,7,7,EMNV_baseline_biological_nanovesicle | Hyb_extrusion_fusion_RNA_loading | FAM_RNA_intracellular_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,source_id,categorical,7,1,KOSTYUSHEVA_BIOLOGICS_HYB_TARGETED_RNA_D,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,toxicity_or_safety_signal_proxy,float,7,4,0.14 | 0.18 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biologics_hyb_targeted_rna_delivery.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
biophysical_properties.csv,biophysical_id,string,1120,1120,BIO_CTRL_OLIGO_NEG_VEHICLE_MOCK | BIO_CTRL_OLIGO_NEG_LOW_RISK | BIO_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,nucleotide_composition_A,integer,1120,18,0 | 8 | 6,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,nucleotide_composition_C,integer,1120,16,0 | 3 | 4,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,nucleotide_composition_G,integer,1120,17,0 | 4 | 5,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,nucleotide_composition_U,integer,1120,16,0 | 10 | 7,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,GC_content,float,1120,177,0.0 | 0.19 | 0.48,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,seed_region_GC,float,1120,14,0.0 | 0.14 | 0.43,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,longest_continuous_complementarity,integer,1120,19,0 | 2 | 5,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,mismatch_count_proxy,integer,1120,17,0 | 8 | 5,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,predicted_offtarget_hybridization_burden,float,1120,986,0.0 | 0.6 | 2.0,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,predicted_Tm_celsius,float,1120,1015,0.0 | 48.0 | 61.5,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,predicted_delta_G_kcal_mol,float,1120,1026,0.0 | -9.5 | -17.5,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,binding_affinity_proxy,float,1120,1015,0.0 | 0.55 | 1.35,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
biophysical_properties.csv,record_origin,categorical,1120,1,dbbun_generated,"Biophysical predictors per oligo: GC content, predicted Tm, ΔG, off-target hybridization burden, sequence-derived risk fields."
brothers_aso_pna_toxicity_mitigation.csv,alt_fold_uln_proxy,float,120,120,2.86136 | 2.8546 | 2.86853,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,aso_type,categorical,120,2,GalNAc_LNA_gapmer_ASO | ASO_PNA_BRO_duplex,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,body_weight_fraction_baseline_proxy,float,120,120,0.93419 | 0.95447 | 0.95169,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,design_class,categorical,120,6,parent_mPCS1_ssASO | BRO_PNA12_high_Tm | BRO_PNA11_high_Tm,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,dose_nmol_per_kg,integer,120,5,25 | 50 | 100,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,duplex_tm_celsius_proxy,float,120,120,-0.5003 | 3.12249 | -0.42215,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,ed50_nmol_per_kg_context_proxy,float,120,6,35.3 | 78.0 | 61.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,judging_alignment,categorical,120,1,Ability_to_Solve_Challenge|Feasibility_a,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,modeling_value,categorical,120,1,direct_ASO_offtarget_hepatotoxicity_miti,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,module_record_id,identifier,120,120,BRO_ASO_PNA_0001 | BRO_ASO_PNA_0002 | BRO_ASO_PNA_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,pcsk9_knockdown_fraction_proxy,float,120,120,0.60552 | 0.54928 | 0.55674,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,pna_brother_strand_length_nt,integer,120,6,0 | 12 | 11,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,protein_binding_score_proxy,float,120,120,0.60402 | 0.66532 | 0.60084,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,rna_offtarget_hybridization_score_proxy,float,120,120,0.77649 | 0.76773 | 0.72702,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,safety_class_generated,categorical,120,3,toxic_active_parent | low_activity_or_context | mitigated_hepatotoxicity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,source_id,categorical,120,1,TERADA_BROTHERS_ASO_PNA_TOEHOLD_2023,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,therapeutic_margin_score_proxy,float,120,120,0.20799 | 0.1891 | 0.19076,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,toehold_domain_present,integer,120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,toehold_mismatch_discrimination_score_proxy,float,120,120,0.22351 | 0.23227 | 0.27298,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
brothers_aso_pna_toxicity_mitigation.csv,value_origin,categorical,120,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_masld_hcc_state,categorical,1120,6,not_modeled | CD133_positive_CSC_MASLD_HCC_MKI_resista | VNP_siCD133_plus_MKI_MASLD_HCC_tumor_sup,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_masld_hcc_context_type,categorical,1120,2,not_applicable | MASLD_HCC_CD133_CSC_siRNA_combination_co,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_csc_enrichment_score_proxy,float,1120,11,0.0 | 0.6903 | 0.15281,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_lineage_expansion_score_proxy,float,1120,11,0.0 | 0.70237 | 0.26398,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_self_renewal_score_proxy,float,1120,11,0.0 | 0.52925 | 0.31909,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_tumor_initiating_capacity_proxy,float,1120,11,0.0 | 0.57136 | 0.3212,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_mki_resistance_score_proxy,float,1120,11,0.0 | 0.64538 | 0.295,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_myh9_interaction_score_proxy,float,1120,11,0.0 | 0.61556 | 0.40532,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_wnt_bcat_activation_score_proxy,float,1120,11,0.0 | 0.65246 | 0.26837,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_active_bcat_repression_after_sicd133_proxy,float,1120,11,0.0 | 0.14181 | 0.92585,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_vnp_sicd133_delivery_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_2prime_ome_pyrimidine_modification_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_sorafenib_combo_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_lenvatinib_combo_context_flag,integer,1120,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_tumor_weight_reduction_score_proxy,float,1120,10,0.0 | 0.01178 | 0.97091,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_ki67_reduction_score_proxy,float,1120,11,0.0 | 0.0748 | 0.7024,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_tunel_apoptosis_increase_score_proxy,float,1120,9,0.0 | 0.18804 | 0.9184,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_masld_hcc_therapeutic_rescue_score_proxy,float,1120,11,0.0 | 0.08229 | 0.88652,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_hepatocarcinogenesis_context_modifier,float,1120,10,0.0 | 0.52621 | 0.6982,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_direct_oligotox_relevance_modifier,float,1120,11,0.0 | 0.12161 | 0.15195,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,cd133_masld_hcc_context_confidence_score,float,1120,11,0.0 | 0.78501 | 0.90674,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,context_note,categorical,1120,3,Supporting CD133/MASLD-HCC siRNA context | Supporting MASLD-HCC CD133 cancer-stem-c | No CD133/MASLD-HCC siRNA context modeled,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd133_masld_hcc_sirna_context.csv,value_origin,categorical,1120,4,literature_grounded_generated | inferred_from_paper | not_reported,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,assumption_id,categorical,6,1,ASM_105,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,delivery_or_targeting_score_proxy,float,6,5,0.88 | 0.92 | 0.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,mechanism_or_specificity_score_proxy,float,6,6,0.76 | 0.78 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,modality_or_platform,categorical,6,2,GalNAc-siRNA | host_target_silencing,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,model_system,string,6,6,Hep3B_and_primary_mouse_hepatocytes | C57BL6_mouse_liver | rodent_malaria_mouse_challenge,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,modeling_role,string,6,6,hepatocyte_target_sequence_screening | durable_hepatocyte_receptor_silencing | host_factor_infection_prevention_endpoin,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,module_id,categorical,6,1,CD81_GalNAc_siRNA_liver_stage_malaria_pr,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,primary_effect_score_proxy,float,6,5,0.82 | 0.86 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,scenario_id,string,6,6,cross_species_siRNA_screen | in_vivo_liver_CD81_knockdown_durability | pyoelii_liver_stage_protection,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,source_id,categorical,6,1,STEEL_CD81_GALNAC_SIRNA_MALARIA_PROTECTI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,toxicity_or_safety_signal_proxy,float,6,4,0.16 | 0.18 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cd81_galnac_sirna_malaria_protection.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
challenge_alignment_scorecard.csv,dataset_evidence,string,10,10,"oligos, chemistry, dose/exposure, assays | information_gap_map.csv maps each source | validation_summary.csv, control profiles",Mapping of dataset components to challenge judging factors.
challenge_alignment_scorecard.csv,demonstration_file,string,10,10,model_readiness_report.csv; validation_s | information_gap_map.csv | validation_summary.csv; data_dictionary.,Mapping of dataset components to challenge judging factors.
challenge_alignment_scorecard.csv,judging_criterion,categorical,10,4,Ability to Solve the Challenge | Potential Impact | Feasibility and Rigor,Mapping of dataset components to challenge judging factors.
challenge_alignment_scorecard.csv,notes,string,10,10,Dataset is structured for in silico olig | Emphasizes gaps not well covered by sing | Reviewer-facing checks are generated wit,Mapping of dataset components to challenge judging factors.
challenge_alignment_scorecard.csv,status,categorical,10,1,demonstrated,Mapping of dataset components to challenge judging factors.
chemical_modifications.csv,modification_id,string,1120,1120,MOD_CTRL_OLIGO_NEG_VEHICLE_MOCK | MOD_CTRL_OLIGO_NEG_LOW_RISK | MOD_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,sugar_chemistry,string,1120,41,not_applicable | 2prime_OMe | mixed,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,backbone_class,categorical,1120,3,low_or_no_PS | partial_PS | high_PS,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,phosphorothioate_fraction,float,1120,906,0.0 | 0.05 | 0.22,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,phosphorothioate_tertile,categorical,1120,3,low_PS | high_PS | medium_PS,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,GalNAc_conjugated,integer,1120,2,0 | 1,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,modification_pattern,string,1120,94,not_applicable | 2prime_OMe|low_PS|GalNAc=0 | mixed|low_PS|GalNAc=1,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,modification_locations,string,1120,29,not_applicable | generated_terminal_and_internal_pattern_ | generated_terminal_and_internal_pattern_,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,purity,float,1120,901,1.0 | 0.985 | 0.975,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,purity_source_label,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,characterization_method,string,1120,60,not_applicable | HPLC+LC-MS | LC-MS,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,characterization_source_label,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,record_origin,categorical,1120,1,dbbun_generated,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
chemical_modifications.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Aggregate chemical modification metadata per oligo: sugar chemistry, backbone class, PS fraction, GalNAc conjugation, purity, characterization method."
cholangiocyte_cholestasis_recovery_context.csv,oligo_id,identifier,21,21,OLIGO_0000018 | OLIGO_0000027 | OLIGO_0000216,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,control_id,categorical,21,5,NON_CONTROL_GENERATED_RECORD | CTRL_POS_DDC_CHOLESTATIC_LIVER_INJURY_AL | CTRL_NEG_CHOLESTASIS_RECOVERY_R15_RESOLU,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,source_id,categorical,21,1,OLSON_CHOLANGIOCYTE_CHOLESTASIS_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,target_gene,string,21,17,CYP2E1 | APOC3 | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,modality,string,21,14,GalNAc-siRNA | gapmer | splice-switching_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,cell_model,unknown,0,0,,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,cholestasis_context_flag,integer,21,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,cholestasis_state,categorical,21,5,generated_cholestatic_cholangiocyte_cont | DDC_peak_cholestatic_liver_injury | R15_recovery_resolution_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,DDC_reversible_cholestasis_model_flag,integer,21,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,ALT_fold_proxy,float,21,21,8.4074 | 15.7998 | 13.9634,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,ALP_fold_proxy,float,21,21,2.4815 | 3.96 | 3.5927,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,bilirubin_fold_proxy,float,21,21,4.3333 | 7.6599 | 6.8335,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,cholesterol_fold_proxy,float,21,21,1.9259 | 2.85 | 2.6204,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,ductular_reaction_CK19_SOX9_score_proxy,float,21,21,0.5988 | 0.7427 | 0.7069,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,CX3CL1_expression_fold_proxy,float,21,20,3.5926 | 6.1799 | 5.5372,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,CX3CR1_macrophage_recruitment_score_proxy,float,21,21,0.4593 | 0.718 | 0.6537,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,PICSS_pathway_activation_score_proxy,float,21,21,0.5093 | 0.768 | 0.7037,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,PICSS_upregulated_gene_count_proxy,integer,21,17,50 | 75 | 68,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,NFYA_nuclear_activation_score_proxy,float,21,21,0.4407 | 0.681 | 0.6213,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,TGFB1_expression_score_proxy,float,21,21,0.4924 | 0.6245 | 0.5917,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,fibrosis_collagen_activation_score_proxy,float,21,21,0.4708 | 0.5435 | 0.5254,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,recovery_resolution_score_proxy,float,21,21,0.6296 | 0.26 | 0.3518,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,siRNA_NFYA_TGFB1_reduction_context_flag,integer,21,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,siRNA_NFYA_TGFB1_reduction_fraction_proxy,float,21,2,0.0 | 0.55,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,direct_oligotox_hepatotoxicity_relevance,categorical,21,1,supporting_not_direct,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,phase2_alignment,categorical,21,1,endpoint_diversity_cholestasis_fibrosis_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,value_origin,categorical,21,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cholangiocyte_cholestasis_recovery_context.csv,assumption_id,categorical,21,1,ASM_041,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
controls.csv,control_id,string,161,161,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,control_type,string,161,154,negative_control_vehicle_mock | negative_control_low_risk_oligo | clinical_low_hepatotoxicity_reference,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,control_role,string,109,109,baseline_no_active_oligo | low_sequence_chemistry_exposure_risk | GalNAc_siRNA_clinical_safety_reference,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,expected_behavior,string,84,68,"no oligo-driven hepatotoxicity signal | high viability, low ALT/AST proxy, low s | low-to-moderate synthetic hepatotoxicity","Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,control_rationale,string,93,60,"Represents mock/vehicle exposure with do | Low PS content, low off-target burden, m | Inspired by a Phase I GalNAc-siRNA trial","Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,source_basis,string,109,51,OligoTox alignment memo control logic | OligoTox predictor framework | RAPIROSIRAN_SANYAL_2025,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,provenance_label,categorical,98,2,literature_grounded_generated | inferred_from_paper,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,record_origin,categorical,161,1,dbbun_generated,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,license_for_generated_output,categorical,161,1,CC BY 4.0,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,expected_direction,string,56,55,low_hepatotoxicity_context | systemic_monitoring_not_primary_hepatoto | durable_PD_context,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,rationale,string,33,33,"Represents zilebesiran-like hepatocyte-t | Keeps hyperkalemia, hypotension, and eGF | Represents prolonged siRNA effect from h","Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,source_id,categorical,35,9,MA_FORMONONETIN_ALDH2_ALD_2025 | VALLE_HOXB7_HNP_TAMOXIFEN_BREAST_2024 | WANG_PMEVL_SEV_SMALL_RNA_PCSK9_2026,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,description,string,52,52,Alcohol-related liver injury context wit | Formononetin-like rescue context with AL | AAV8 siRNA knockdown context in which lo,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,expected_response,string,17,17,high_hepatotoxicity | low_hepatotoxicity | screening_context,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
controls.csv,expected_outcome,string,4,4,high_cholestatic_liver_injury_signal | resolved_or_low_cholestatic_liver_injury | cholangiocyte_macrophage_interaction_con,"Positive, negative, vehicle, and platform-specific control oligos with rationale, derived from the literature."
cpg_odn_apap_macrophage_immunomodulation.csv,acod1_irg1_expression_score_proxy,float,60,56,0.0 | 0.78419 | 0.85563,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,alt_fold_baseline_proxy,float,60,60,4.83313 | 2.72066 | 2.71467,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,apap_dose_mg_per_kg_context,integer,60,1,300,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,cpg_odn_dose_mg_per_kg_context,float,60,2,0.0 | 1.65,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,hepatocyte_viability_proxy,float,60,60,0.33992 | 0.82849 | 0.89456,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,inflammatory_cytokine_burden_proxy,float,60,60,0.80217 | 0.35343 | 0.35178,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,interpretation,categorical,60,3,APAP_liver_injury_reference | protective_macrophage_immunomodulation | loss_of_mechanism_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,itaconate_metabolite_score_proxy,float,60,60,0.04951 | 0.82117 | 0.91427,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,judging_alignment,categorical,60,1,Potential_Impact|Feasibility_and_Rigor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,macrophage_apoptosis_score_proxy,float,60,60,0.67357 | 0.12694 | 0.13935,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,modeling_value,categorical,60,1,immune_cell_liver_injury_context_and_mec,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,module_record_id,identifier,60,60,CPG_APAP_0001 | CPG_APAP_0002 | CPG_APAP_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,nfkb_activation_score_proxy,float,60,37,0.0 | 0.73879 | 0.66751,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,nrf2_antioxidant_response_score_proxy,float,60,60,0.28645 | 0.84815 | 0.82064,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,oligodeoxynucleotide_class,categorical,60,1,CpG_ODN_1826_like,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,ros_score_proxy,float,60,60,0.76397 | 0.24291 | 0.26175,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,scenario,categorical,60,5,APAP_only | CpG_ODN_pretreatment | CpG_ODN_treated_macrophage_reinfusion,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,source_id,categorical,60,1,QU_CPG_ODN_APAP_TLR9_IRG1_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,survival_improvement_score_proxy,float,60,60,0.32511 | 0.76079 | 0.72887,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,target_cell_context,categorical,60,4,AML12_hepatocyte_coculture | RAW2647_macrophage | Kupffer_cell,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,tlr9_activation_score_proxy,float,60,37,0.0 | 0.60034 | 0.84461,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cpg_odn_apap_macrophage_immunomodulation.csv,value_origin,categorical,60,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,assumption_id,categorical,6,1,ASM_122,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,delivery_or_targeting_score_proxy,float,6,6,0.12 | 0.16 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,mechanism_or_specificity_score_proxy,float,6,5,0.84 | 0.88 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,modality_or_platform,string,6,6,liver_injury_context | regulated_cell_death_mechanism | dose_response_stress,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,model_system,string,6,6,ATP7B_knockout_mouse_Wilson_disease_mode | ATP7B_KO_liver_and_HepG2_cuproptosis_mod | copper_exposed_HepG2_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,modeling_role,string,6,6,copper_overload_ALT_AST_LDH_hepatocellul | FDX1_DLAT_DLST_LIAS_mitochondrial_cell_d | copper_dose_viability_and_cytotoxicity_r,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,module_id,categorical,6,1,ATP7B_copper_cuproptosis_liver_injury_si,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,primary_effect_score_proxy,float,6,6,0.76 | 0.72 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,scenario_id,string,6,6,ATP7B_KO_copper_overload_liver_injury | cuproptosis_marker_activation | copper_exposure_LDH_viability_shift,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,source_id,categorical,6,1,TANG_CUPROPTOSIS_WILSON_DISEASE_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,toxicity_or_safety_signal_proxy,float,6,6,0.64 | 0.56 | 0.6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
cuproptosis_wilson_liver_injury.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
data_dictionary.csv,allowed_values_or_range,categorical,82,11,0 or 1 | 0 to 1 | controlled generated categories,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
data_dictionary.csv,column_name,string,256,253,source_id | title | source_role,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
data_dictionary.csv,data_type,categorical,367,7,string_or_numeric | integer_flag | float,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
data_dictionary.csv,description,string,380,369,Unique source identifier. | Source paper or memo title. | How the source contributes to generation,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
data_dictionary.csv,field_name,string,124,122,preprint_caution_flag | ALT_AST_safety_monitoring_score_proxy | delivery_translatability_score_proxy,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
data_dictionary.csv,origin_rule,categorical,256,1,reported/extracted/inferred/generated/no,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
data_dictionary.csv,provenance,categorical,13,1,literature_grounded_generated,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
data_dictionary.csv,provenance_expectation,categorical,35,2,source_metadata | literature_grounded_generated,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
data_dictionary.csv,required,categorical,367,2,yes | no,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
data_dictionary.csv,table_name,string,380,79,sources.csv | controls.csv | oligos.csv,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
data_dictionary.csv,type,categorical,13,1,float_or_string,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
data_dictionary.csv,value_origin,categorical,76,1,literature_grounded_generated,"Curated variable-level definitions, units, and value ranges for the core modeling tables."
dilimap_toxpredictor_dili_toxicogenomics.csv,assumption_id,categorical,6,1,ASM_111,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,delivery_or_targeting_score_proxy,float,6,4,0.32 | 0.36 | 0.38,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,mechanism_or_specificity_score_proxy,float,6,4,0.94 | 0.92 | 0.96,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,modality_or_platform,string,6,6,toxicogenomics | ML_toxicity_model | random_forest_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,model_system,string,6,6,sandwich_cultured_primary_human_hepatocy | multi_concentration_transcriptomics_PK_c | DILI_positive_negative_validation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,modeling_role,string,6,6,large_scale_human_hepatocyte_reference_r | dose_and_exposure_resolved_modeling_cont | validation_sensitivity_specificity_conte,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,module_id,categorical,6,1,DILImap_ToxPredictor_DILI_toxicogenomics,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,primary_effect_score_proxy,float,6,6,0.72 | 0.74 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,scenario_id,string,6,6,PHH_RNAseq_300_compound_library | dose_resolved_DILI_safety_margin | blind_validation_high_specificity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,source_id,categorical,6,1,BERGEN_DILIMAP_TOXPREDICTOR_DILI_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,toxicity_or_safety_signal_proxy,float,6,5,0.2 | 0.22 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dilimap_toxpredictor_dili_toxicogenomics.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dose_exposure.csv,dose_exposure_id,string,1120,1120,DOSE_CTRL_OLIGO_NEG_VEHICLE_MOCK | DOSE_CTRL_OLIGO_NEG_LOW_RISK | DOSE_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
dose_exposure.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
dose_exposure.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
dose_exposure.csv,dose_nM,float,1120,899,0.0 | 10.0 | 180.0,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
dose_exposure.csv,dose_tier,categorical,1120,6,vehicle_or_mock | very_low | medium,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
dose_exposure.csv,exposure_duration_days,integer,1120,24,1.0 | 3.0 | 84.0,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
dose_exposure.csv,treatment_frequency,string,1120,54,single | monthly | weekly,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
dose_exposure.csv,relative_exposure_normalization,float,1120,888,0.0 | 0.06667 | 1.2,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
dose_exposure.csv,relative_exposure_basis,categorical,1120,1,multiples_of_150_nM_reference,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
dose_exposure.csv,dose_source_label,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
dose_exposure.csv,record_origin,categorical,1120,1,dbbun_generated,"Dose, exposure duration, treatment frequency, and exposure normalization per oligo."
dual_rgd_sirna_nanocarrier_delivery.csv,assumption_id,categorical,6,1,ASM_101,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,challenge_alignment,categorical,6,1,"supporting module for delivery, immune-c",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,delivery_or_targeting_score_proxy,float,6,6,0.7 | 0.62 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,immune_or_cell_state_score_proxy,float,6,4,0.45 | 0.4 | 0.55,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,modality_or_platform,string,6,5,noncationic_protein_carrier | dual_RGD_targeting | histidine_buffering,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,model_system,string,6,6,in_vitro_binding | serum_RNase_assay | integrin_positive_cells,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,modeling_role,string,6,6,load_to_go_siRNA_binding | siRNA_protection_context | tumor_targeting_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,module_id,categorical,6,1,dual_RGD_non_cationic_siRNA_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,primary_effect_score_proxy,float,6,6,0.88 | 0.82 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,scenario_id,string,6,6,dual_RGD_dsRBD_18His_binding | RNase_serum_stability | integrin_avb3_targeting,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,source_id,categorical,6,1,YU_DUAL_RGD_DSRBD_18HIS_TUMOR_SIRNA_DELI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,toxicity_or_safety_signal_proxy,float,6,6,0.16 | 0.14 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
dual_rgd_sirna_nanocarrier_delivery.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,epigenetic_context_id,string,1120,1120,EPI_CTRL_OLIGO_NEG_VEHICLE_MOCK | EPI_CTRL_OLIGO_NEG_LOW_RISK | EPI_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,epigenetic_liver_state,categorical,1120,6,baseline | SULT1B1_siRNA_rescue | MASLD_H3K27ac_high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,h3k27ac_super_enhancer_activity_proxy,float,1120,1043,0.29499 | 0.38197 | 0.2496,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,cebp_beta_activity_proxy,float,1120,1047,0.49209 | 0.41983 | 0.49633,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,sult1b1_expression_proxy,float,1120,1042,0.15097 | 0.38913 | 0.26762,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,oleate_lipid_loading_model,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,jq1_like_SE_inhibition,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,sult1b1_siRNA_knockdown,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,cebp_beta_siRNA_knockdown,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,hepatocyte_lipid_accumulation_proxy,float,1120,1033,0.18698 | 0.34023 | 0.16991,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,epigenetic_liver_stress_modifier,float,1120,1002,0.11709 | 0.17455 | 0.10737,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,epigenetic_rescue_score,float,1120,4,0.0 | 0.4 | 0.35,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,epigenetic_lipid_context_label,categorical,1120,3,low | high | moderate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,super_enhancer_activity_label,categorical,1120,3,low | moderate | high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,context_note,categorical,1120,1,supporting MASLD epigenetic/lipid-accumu,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
epigenetic_liver_context.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,aptamer_length_nt_context,integer,55,1,40,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,auc_0_5400_proxy,float,55,55,12.30571 | 12.67163 | 15.87586,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,biliary_excretion_fraction_context,float,5,1,0.083,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,cmax_percent_injected_dose_per_g_proxy,float,55,55,7.32945 | 7.74009 | 7.89772,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,dominant_excretion_or_distribution_route,categorical,55,9,systemic_distribution | renal_excretion | hepatic_biliary_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,estimated_effective_dose_mGy_per_MBq_context,float,55,1,0.00189,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,hepatobiliary_or_renal_burden_flag,integer,55,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,judging_alignment,categorical,55,1,Feasibility_and_Rigor|Transparency_and_R,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,modeling_value,categorical,55,1,oligonucleotide_ADME_PK_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,module_record_id,string,55,55,ERBB2_APT_PK_0001 | ERBB2_APT_PK_0002 | ERBB2_APT_PK_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,oligonucleotide_type,categorical,55,1,ERBB2_specific_DNA_aptamer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,organ_or_tissue,categorical,55,11,heart | kidney | liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,radiolabeling_strategy,categorical,55,1,fluorine18_complementary_oligonucleotide,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,renal_excretion_fraction_context,float,10,1,0.778,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,route,categorical,55,1,intravenous,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,source_id,categorical,55,1,PARK_ERBB2_APTAMER_PET_PK_2023,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,target,categorical,55,1,ERBB2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,target_visualization_score_proxy,float,55,51,0.43803 | 0.46311 | 0.48553,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,terminal_half_life_seconds_proxy,float,55,55,1605.21774 | 1787.76691 | 1645.95571,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,tmax_seconds_proxy,float,55,55,222.74629 | 332.91156 | 278.52277,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
erbb2_aptamer_pet_pk.csv,value_origin,categorical,55,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,ALT_elevation_liability_proxy,float,25,25,0.14811 | 0.20586 | 0.45626,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,ESCplus_flag,integer,25,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,GNA_seed_flag,integer,25,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,assumption_id,categorical,25,1,ASM_062,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,challenge_gap_addressed,categorical,25,1,public_data_gap_for_GalNAc_siRNA_seed_of,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,chemistry_vs_global_tm_note,categorical,25,1,single_seed_GNA_or_2_5_RNA_modeled_as_sp,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,design_class,categorical,25,5,parent_ESC_GalNAc_siRNA | ESCplus_single_GNA_position6 | ESCplus_single_2_5_RNA_seed,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,dose_mg_per_kg_proxy,integer,25,5,1 | 3 | 10,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,judging_alignment,categorical,25,1,Ability_to_Solve|Potential_Impact|Feasib,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,modality,categorical,25,1,GalNAc_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,modeling_value,categorical,25,1,"directly supports seed-region chemistry,",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,module_record_id,string,25,25,supplemental_ESCPLUS_parent_ESC_GalNAc_s | supplemental_ESCPLUS_parent_ESC_GalNAc_s | supplemental_ESCPLUS_parent_ESC_GalNAc_s,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,on_target_activity_retention_proxy,float,25,23,1.0 | 0.97451 | 0.9318,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,predicted_offtarget_transcript_dysregulation_proxy,float,25,25,0.02201 | 0.20319 | 0.35283,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,seed_mediated_offtarget_binding_proxy,float,25,25,0.14563 | 0.23173 | 0.41861,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,seed_pairing_destabilization_score_proxy,float,25,25,0.85153 | 0.84323 | 0.82614,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,seed_region_modification,categorical,25,4,none | GNA_position6 | 2_5_RNA_seed,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,source_id,categorical,25,1,SCHLEGEL_ESCPLUS_SEED_PAIRING_GALNAC_SIR,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,source_role,categorical,25,1,direct_GalNAc_siRNA_offtarget_hepatotoxi,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,target_context,categorical,25,1,HBV_or_liver_expressed_target_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,therapeutic_window_proxy,float,25,25,3.04772 | 2.52553 | 1.46449,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
escplus_seed_pairing_safety_mechanism.csv,value_origin,categorical,25,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,extrahepatic_delivery_id,string,1120,1120,EXTRA_CTRL_OLIGO_NEG_VEHICLE_MOCK | EXTRA_CTRL_OLIGO_NEG_LOW_RISK | EXTRA_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,extrahepatic_delivery_state,categorical,1120,5,baseline_liver_focused | dystrophic_muscle_delivery | extrahepatic_delivery_with_liver_exposur,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,extrahepatic_conjugate_type,categorical,1120,2,none | cholesterol_conjugate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,extrahepatic_administration_route,categorical,1120,5,not_extrahepatic_context | intraperitoneal | intravenous,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,systemic_dose_mg_per_kg_proxy,integer,1120,3,0.0 | 10.0 | 20.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,extrahepatic_dosing_schedule,categorical,1120,5,not_applicable | weekly_x4 | single,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,treatment_duration_weeks_proxy,integer,1120,3,0.0 | 4.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,target_tissue_class,categorical,1120,4,not_extrahepatic_context | mdx_dystrophic_skeletal_muscle | mixed_muscle_and_liver_distribution,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,dystrophic_muscle_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,skeletal_muscle_knockdown_pct_proxy,float,1120,22,0.0 | 36.0 | 24.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,tibialis_anterior_knockdown_pct_proxy,float,1120,22,0.0 | 39.7 | 18.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,diaphragm_knockdown_pct_proxy,float,1120,22,0.0 | 32.7 | 15.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,heart_knockdown_pct_proxy,float,1120,21,0.0 | 12.0 | 10.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,liver_knockdown_pct_proxy,float,1120,17,0.0 | 41.3 | 44.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,liver_marker_signal_fold_proxy,float,1120,22,1.0 | 1.02 | 1.05,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,kidney_urea_signal_fold_proxy,float,1120,21,1.0 | 1.05 | 1.28493,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,extrahepatic_delivery_confidence_score,float,1120,22,0.0 | 0.65875 | 0.52045,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,liver_exposure_context_label,categorical,1120,2,minimal_or_not_modeled | measurable_liver_knockdown_without_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,context_note,categorical,1120,2,extrahepatic delivery/distribution conte | extrahepatic delivery context; not a dir,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
extrahepatic_delivery.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,EMT_reversal_score_proxy,float,6,6,0.06 | 0.08 | 0.35,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,H3K27me3_residual_score_proxy,float,6,6,0.9 | 0.82 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,apoptosis_or_cell_cycle_effect_score_proxy,float,6,6,0.08 | 0.12 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,challenge_alignment,categorical,6,1,supports ability-to-solve by adding spli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,exon14_skipping_score_proxy,float,6,6,0.03 | 0.06 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,full_length_EZH2_residual_score_proxy,float,6,6,0.92 | 0.86 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,liver_relevance,categorical,6,1,HCC_liver_therapeutic_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,mechanism,categorical,6,1,steric_blocking_exonic_splicing_enhancer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,model_system,string,6,4,MHCC97H_HCC | HCCLM3_HCC | mouse_peripheral_tissue_liver_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,modeling_role,string,6,6,baseline_HCC_control | sequence_specificity_control | lead_splice_switching_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,module_id,categorical,6,1,EZH2_exon_skipping_HCC_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,notes,categorical,6,1,Generated scenario row; proxy values enc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,oligo_modality,categorical,6,1,splice_switching_MOE_PS_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,scenario_id,string,6,6,buffer_control_HCC_cells | mismatch_MOE_PS_ASO | lead_ASO35_58_25nM,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,source_id,categorical,6,1,BAI_EZH2_EXON_SKIPPING_HCC_ASO_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,study_context,categorical,6,2,in_vitro | in_vivo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,target_or_splicing_element,string,6,3,none | mismatch_control | EZH2_exon14_ESE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,tumor_growth_inhibition_score_proxy,float,6,6,0.1 | 0.14 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ezh2_exon_skipping_hcc_aso.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_hcc_state,categorical,1120,5,not_modeled | generic_FBLL1_HCC_context | FBLL1_high_malignant_hepatocyte_spatial_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_expression_context,categorical,1120,3,not_applicable | high_FBLL1 | FBLL1_knockdown,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_malignant_hepatocyte_enrichment_score,float,1120,150,0.0 | 0.76989 | 0.89287,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_spatial_tumor_niche_score,float,1120,149,0.0 | 0.85403 | 0.90992,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_high_expression_survival_risk_proxy,float,1120,151,0.0 | 0.66233 | 0.91136,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_ribosome_biogenesis_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_siRNA_knockdown_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_knockdown_proliferation_suppression_proxy,float,1120,126,0.0 | 0.1273 | 0.18117,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_knockdown_colony_suppression_proxy,float,1120,121,0.0 | 0.3092 | 0.05518,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_overexpression_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_overexpression_tumorigenesis_proxy,float,1120,150,0.0 | 0.2359 | 0.00794,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_hepatocyte_dedifferentiation_score_proxy,float,1120,154,0.0 | 0.78178 | 0.56324,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_ALB_downregulation_proxy,float,1120,159,0.0 | 1.07112 | 1.39801,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_MYC_upregulation_proxy,float,1120,145,0.0 | 0.73209 | 0.20102,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_EGFR_ligand_upregulation_score_proxy,float,1120,141,0.0 | 0.9713 | 0.96127,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_EGFR_MAPK_activation_score_proxy,float,1120,156,0.0 | 0.67626 | 0.26712,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_HCC_malignant_context_modifier,float,1120,159,0.0 | 0.81614 | 0.77149,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_direct_oligotox_relevance_modifier,float,1120,5,0.0 | 0.1 | 0.05,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,fbll1_context_confidence_score,float,1120,159,0.0 | 0.68903 | 0.79043,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,context_note,categorical,1120,3,No FBLL1/HCC context modeled for this ro | Supporting FBLL1/HCC spatial multi-omics | Supporting FBLL1/HCC context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fbll1_hcc_spatial_oncogenic_context.csv,value_origin,categorical,1120,4,not_reported | literature_grounded_generated | inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,GalNAc_or_hepatocyte_targeting_context,string,4,2,yes | yes_contextual_GalNAc_hepatocyte_targeti,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,active_ingredient_or_landscape_item,string,4,4,fitusiran | donidalorsen | plozasiran,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,administration_route,categorical,4,1,subcutaneous,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,assumption_id,categorical,4,1,ASM_129,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,clinical_maturity_score_proxy,float,4,3,0.92 | 0.9 | 0.95,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,direct_oligotox_row_level_endpoint,categorical,4,1,no_landscape_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,indication_context,string,4,4,hemophilia_A_or_B_bleeding_prevention | hereditary_angioedema_attack_prevention | familial_chylomicronemia_syndrome_trigly,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,modality_context,string,4,3,siRNA | ASO_or_ligand_conjugated_oligo_context | GalNAc_platform,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,module_id,categorical,4,1,FDA_TIDES_2025_oligonucleotide_landscape,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,notes,categorical,4,1,Landscape row for current approved oligo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,provenance_label,categorical,4,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,source_id,categorical,4,1,ALSHAER_FDA_TIDES_HARVEST_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,therapeutic_target,string,4,4,antithrombin_III_mRNA | prekallikrein_mRNA | APOC3_mRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,trade_name_or_summary_label,string,4,4,Qfitlia | Dawnzera | Redemplo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fda_tides_2025_oligo_landscape.csv,value_origin,categorical,4,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
figure_label_dictionary.csv,display_label,string,12,12,Gapmer ASO | GalNAc-LNA ASO | EV liver context,Definitions of figure labels and panel descriptions.
figure_label_dictionary.csv,figure,categorical,12,1,fig07,Definitions of figure labels and panel descriptions.
figure_label_dictionary.csv,full_modality_name,string,12,12,gapmer | GalNAc-LNA-ASO | extracellular_vesicle_liver_context,Definitions of figure labels and panel descriptions.
figure_label_dictionary.csv,median_risk_score,float,12,10,10.0 | 9.78578 | 9.76845,Definitions of figure labels and panel descriptions.
figure_label_dictionary.csv,n_readouts,integer,12,10,1695 | 1155 | 150,Definitions of figure labels and panel descriptions.
formononetin_aldh2_nrf2_ald_context.csv,oligo_id,string,3,3,OLIGO_CTRL_POS_ALD_ACETALDEHYDE_ROS_MITO | OLIGO_CTRL_NEG_FORMONONETIN_ALDH2_NRF2_H | OLIGO_CTRL_CONTEXT_ALDH2_NRF2_SIRNA_LOSS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,source_id,categorical,3,1,MA_FORMONONETIN_ALDH2_ALD_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,control_id,string,3,3,CTRL_POS_ALD_ACETALDEHYDE_ROS_MITOCHONDR | CTRL_NEG_FORMONONETIN_ALDH2_NRF2_HEPATOP | CTRL_CONTEXT_ALDH2_NRF2_SIRNA_LOSS_OF_RE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,target_gene,string,3,3,ALDH2 | NFE2L2 | ALDH2_NFE2L2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,oligo_modality,categorical,3,1,siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,aldh2_nrf2_ald_state,string,3,2,formononetin_ALDH2_Nrf2_hepatoprotection | ALDH2_or_Nrf2_siRNA_loss_of_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,alcohol_related_liver_disease_context_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,formononetin_like_treatment_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,AAV8_siRNA_ALDH2_or_Nrf2_knockdown_context_flag,integer,3,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,ALDH2_activity_fold_proxy,float,3,2,1.28 | 0.34,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,acetaldehyde_burden_fold_proxy,float,3,2,0.58 | 2.6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,hepatic_ROS_fold_proxy,float,3,2,0.52 | 2.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,lipid_peroxidation_TBARS_fold_proxy,float,3,2,0.478 | 2.208,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,four_HNE_signal_fold_proxy,float,3,2,0.458 | 2.112,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,mitochondrial_quantity_TOM20_fold_proxy,float,3,2,1.18 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,NAD_NADH_ratio_fold_proxy,float,3,2,1.133 | 0.403,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,ATP_level_fold_proxy,float,3,2,1.097 | 0.391,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,complex_I_activity_fold_proxy,float,3,2,1.062 | 0.378,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,Nrf2_activity_fold_proxy,float,3,2,1.35 | 0.31,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,HO1_expression_fold_proxy,float,3,2,1.418 | 0.326,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,GSH_GSSG_ratio_fold_proxy,float,3,2,1.22 | 0.38,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,GPX4_level_fold_proxy,float,3,2,1.159 | 0.361,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,ERK1_2_AP1_activation_context_score,float,3,1,0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,ALT_AST_liver_injury_fold_proxy,float,3,2,0.72 | 1.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,ALD_oxidative_stress_modifier,float,3,2,-0.804 | 2.471,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,ALD_context_confidence_score,float,3,1,0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,assumption_id,categorical,3,1,ASM_029,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
formononetin_aldh2_nrf2_ald_context.csv,record_origin,categorical,3,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,ALT_signal_proxy,float,18,18,0.0 | 0.06004 | 0.13932,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,AST_signal_proxy,float,18,18,0.0 | 0.0834 | 0.03869,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,FXR_protective_axis_score_proxy,float,18,18,0.81342 | 0.83357 | 0.79115,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,G0s2_expression_proxy,float,18,18,0.76041 | 0.80551 | 0.77367,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,JNK_activation_proxy,float,18,18,0.0 | 0.01652 | 0.05831,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,assumption_id,categorical,18,1,ASM_064,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,bile_acid_disorder_proxy,float,18,18,0.03955 | 0.09328 | 0.13015,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,carnitine_disorder_proxy,float,18,18,0.06449 | 0.15989 | 0.11304,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,challenge_gap_addressed,categorical,18,1,mechanistic_liver_toxicity_pathway_covar,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,injury_model,categorical,18,1,triptolide_induced_hepatotoxicity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,intervention_arm,categorical,18,6,vehicle_control | triptolide_DILI | triptolide_plus_JNK_inhibitor_SP600125,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,judging_alignment,categorical,18,1,Ability_to_Solve|Potential_Impact,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,long_chain_fatty_acid_disorder_proxy,float,18,18,0.11929 | 0.1 | 0.07044,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,metabolic_hepatotoxicity_score_proxy,float,18,18,0.03 | 0.0802 | 0.0923,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,modality,categorical,18,1,DILI_pathway_siRNA_mechanism_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,modeling_value,categorical,18,1,supports liver-injury pathway features f,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,module_record_id,string,18,18,supplemental_DILI_vehicle_control_6h | supplemental_DILI_vehicle_control_24h | supplemental_DILI_vehicle_control_48h,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,siRNA_knockdown_context_flag,integer,18,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,source_id,categorical,18,1,LI_FXR_JNK_G0S2_TRIPTOLIDE_HEPATOTOXICIT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,source_role,categorical,18,1,supporting_liver_injury_metabolic_pathwa,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,timepoint_hour,integer,18,3,6 | 24 | 48,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
fxr_jnk_g0s2_dili_context.csv,value_origin,categorical,18,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,oligo_id,string,196,196,CTRL_OLIGO_POS_HIGH_OFFTARGET | CTRL_OLIGO_POS_TRANSCRIPTOMIC_STRESS | CTRL_OLIGO_NEG_ANGPTL3_SIRNA_LIVER_SAFET,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,control_id,categorical,196,19,CTRL_POS_HIGH_OFFTARGET | CTRL_POS_TRANSCRIPTOMIC_STRESS | CTRL_NEG_ANGPTL3_SIRNA_LIVER_SAFETY,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,source_id,string,196,44,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | OOSTVEEN_ANGPTL3_LIVER_SAFETY_2023 | PNPLA3_ROMEO_VALENTI_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,target_gene,string,196,58,generic_offtarget | generic_stress_pathway | ANGPTL3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,modality,categorical,196,15,siRNA | GalNAc-siRNA | gapmer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,dose,float,196,185,420.0 | 650.0 | 200.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,hepatotox_score,float,196,182,9.45832434447446 | 9.42258069012478 | 3.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_liver_delivery_context_flag,integer,196,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_liver_delivery_state,categorical,196,7,generated_GalNAc_siRNA_delivery_context | generated_GalNAc_delivery_review_context | generated_GalNAc_ASO_delivery_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_delivery_modality_class,categorical,196,5,GalNAc_siRNA | GalNAc_cross_platform | GalNAc_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,asgpr_hepatocyte_targeting_flag,integer,196,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,asgpr_receptor_copies_per_hepatocyte_proxy,integer,196,1,500000,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_cluster_valency_proxy,categorical,196,2,triantennary_or_trivalent | tetravalent_or_alternative_cluster,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_cluster_position_proxy,categorical,196,1,3prime_sense_strand_siRNA_or_5prime_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,naked_ASO_nonparenchymal_liver_uptake_pct_proxy,float,196,1,0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_ASO_hepatocyte_uptake_pct_proxy,float,196,175,0.8699 | 0.8486 | 0.9045,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_ASO_or_siRNA_potency_improvement_fold_proxy,float,196,196,71.9496 | 19.3095 | 9.5914,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_siRNA_ESC_or_ESCplus_context_flag,integer,196,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_ESCplus_seed_offtarget_mitigation_score_proxy,float,196,188,0.9113 | 0.4739 | 0.538,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,reversir_reversal_context_flag,integer,196,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_endosomal_escape_efficiency_pct_proxy,float,196,191,0.4531 | 0.8499 | 0.3083,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_monomer_loss_hours_proxy,float,196,195,1.0809 | 0.9203 | 0.7765,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_cluster_arm_cleavage_hours_proxy,float,196,196,4.2887 | 3.9335 | 4.0763,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,asgpr_saturation_high_dose_context_flag,integer,196,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_kidney_distribution_shift_score_proxy,float,196,192,0.3328 | 0.4119 | 0.3322,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_liver_to_kidney_distribution_ratio_proxy,float,196,195,2.608 | 1.9805 | 1.8949,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,registered_givosiran_context_flag,integer,196,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,clinical_pipeline_conjugate_count_proxy,integer,196,1,29,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,clinical_ALT_injection_reaction_monitoring_score_proxy,float,196,193,0.4598 | 0.5116 | 0.3931,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_delivery_therapeutic_window_score_proxy,float,196,185,0.8778 | 0.7685 | 0.6845,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,galnac_delivery_review_source_id,categorical,196,1,DEBACKER_GALNAC_LIVER_DELIVERY_REVIEW_20,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,value_origin,categorical,196,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_liver_delivery_review_context.csv,assumption_id,categorical,196,1,ASM_036,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,galnac_lnp_mkk4_state,categorical,1120,8,not_modeled | biocompatible_GalNAc_LNP_siMKK4_delivery | GalNAc_LNP_siMKK4_ACLF_regeneration_resc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_therapeutic_goal,categorical,1120,3,not_applicable | promote_liver_regeneration | injury_model_background,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_dual_targeting_context,categorical,1120,2,not_applicable | LNP_liver_tropism_plus_GalNAc_ASGPR_hepa,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_target_selectivity_mkk7_avoidance_score,float,1120,53,0.0 | 0.82337 | 0.77541,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_dotap_mol_pct_proxy,integer,1120,2,0.0 | 50.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_dspc_mol_pct_proxy,integer,1120,2,0.0 | 5.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_cholesterol_mol_pct_proxy,integer,1120,2,0.0 | 40.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_galnac_peg_dspe_mol_pct_proxy,integer,1120,2,0.0 | 5.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_np_ratio_proxy,integer,1120,2,0.0 | 6.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_particle_size_nm_proxy,float,1120,53,0.0 | 183.89947 | 171.3536,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_zeta_potential_mV_proxy,float,1120,53,0.0 | 25.43536 | 23.91005,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_pdi_proxy,float,1120,53,0.0 | 0.16935 | 0.17381,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_encapsulation_efficiency_pct_proxy,float,1120,38,0.0 | 92.87302 | 96.12801,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_gene_loading_pct_proxy,float,1120,37,0.0 | 2.72346 | 2.64053,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_rnase_protection_score_proxy,float,1120,42,0.0 | 0.88187 | 0.9479,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_siRNA_release_96h_pct_proxy,float,1120,31,0.0 | 40.59554 | 43.90138,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_hemolysis_pct_proxy,float,1120,34,0.0 | 1.47446 | 2.54001,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_liver_tropism_score,float,1120,53,0.0 | 0.84115 | 0.91175,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_hepatocyte_targeting_score,float,1120,53,0.0 | 0.91341 | 0.93345,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_kupffer_endothelial_offtarget_reduction_score,float,1120,50,0.0 | 0.79066 | 0.81439,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_mkk4_knockdown_score,float,1120,47,0.0 | 0.85347 | 0.55407,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_p_p38_reduction_score_proxy,float,1120,50,0.0 | 0.80704 | 0.44502,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_p_mkk7_activation_score_proxy,float,1120,53,0.0 | 0.79779 | 0.68029,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_p_jnk1_activation_score_proxy,float,1120,53,0.0 | 0.86172 | 0.51985,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_p_elk1_activation_score_proxy,float,1120,53,0.0 | 0.81428 | 0.65998,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_p_atf2_activation_score_proxy,float,1120,53,0.0 | 0.7893 | 0.6173,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_aml12_cell_viability_recovery_pct_proxy,float,1120,53,0.0 | 73.89268 | 63.88135,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_ki67_proliferation_score_proxy,float,1120,51,0.0 | 0.80589 | 0.69453,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_liver_regeneration_score_proxy,float,1120,51,0.0 | 0.80589 | 0.69453,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_apoptosis_reduction_score_proxy,float,1120,53,0.0 | 0.64719 | 0.42503,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_liver_function_recovery_score_proxy,float,1120,53,0.0 | 0.59367 | 0.57237,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_aclf_model_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_direct_hepatotoxicity_modifier,float,1120,47,0.0 | 0.16181 | 0.15177,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,mkk4_lnp_context_confidence_score,float,1120,53,0.0 | 0.89122 | 0.93403,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,context_note,categorical,1120,3,No GalNAc-LNP-siMKK4 context modeled for | Supporting GalNAc-LNP-siMKK4 hepatocyte  | Supporting GalNAc-LNP-siMKK4 delivery/re,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_lnp_mkk4_liver_regeneration.csv,value_origin,categorical,1120,4,not_reported | inferred_from_paper | literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,galnac_rbc_ev_state,categorical,1120,5,not_modeled | GalNAc_RBC_EV_ASGPR_hepatocyte_targeted_ | RBC_EV_GalNAc_miR155_ASO_ALF_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,galnac_rbc_ev_context_type,categorical,1120,6,not_modeled | delivery_biosafety | ALF_miR155_ASO_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_particle_size_nm_proxy,float,1120,17,0.0 | 120.2949 | 117.77362,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_galnac_surface_anchor_flag,integer,1120,2,0.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_asgpr_hepatocyte_uptake_score_proxy,float,1120,15,0.0 | 0.87888 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_kupffer_relative_uptake_score_proxy,float,1120,17,0.0 | 0.19799 | 0.10241,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_freeze_thaw_stability_score_proxy,float,1120,17,0.0 | 0.90936 | 0.97,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_payload_type,categorical,1120,6,not_modeled | GalNAc_RBC_EV_only | GalNAc_miR155_ASO_on_RBC_EV,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_pj34_loading_ug_per_100ug_ev_proxy,float,1120,13,0.0 | 5.50223 | 4.3153,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_mir155_knockdown_score_proxy,float,1120,14,0.0 | 0.08241 | 0.73229,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_rab7_knockdown_score_proxy,float,1120,14,0.0 | 0.18016 | 0.04953,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_parp1_par_reduction_score_proxy,float,1120,13,0.0 | 0.097 | 0.67905,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_alf_alt_ast_reduction_score_proxy,float,1120,8,0.0 | 0.72592 | 0.85525,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_panoptosis_reduction_score_proxy,float,1120,8,0.0 | 0.84345 | 0.76362,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_nafld_steatosis_reduction_score_proxy,float,1120,7,0.0 | 0.61844 | 0.70215,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_hcc_drug_retention_score_proxy,float,1120,8,0.0 | 0.74295 | 0.8428,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_hcc_tumor_suppression_score_proxy,float,1120,8,0.0 | 0.71941 | 0.66561,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_vital_organ_toxicity_score_proxy,float,1120,17,0.0 | 0.08768 | 0.04857,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_alt_ast_no_toxicity_flag,integer,1120,2,0.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_histopathology_no_toxicity_flag,integer,1120,2,0.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,rbc_ev_context_confidence_score,float,1120,17,0.0 | 0.94196 | 0.91389,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,context_note,categorical,1120,3,Supporting GalNAc-RBC-EV liver delivery  | Supporting GalNAc-modified RBC-EV hepato | No GalNAc-RBC-EV context modeled.,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_rbc_ev_liver_delivery.csv,value_origin,categorical,1120,4,literature_grounded_generated | inferred_from_paper | not_reported,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,ALT_AST_toxicity_signal_score_proxy,float,5,3,0.08 | 0.12 | 0.1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,CEBPB_knockdown_score_proxy,float,5,2,0.8 | 0.45,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,albumin_bilirubin_function_context,categorical,5,2,not_primary_endpoint | included,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,assumption_id,categorical,5,1,ASM_082,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,challenge_alignment,categorical,5,1,directly supports ability-to-solve and p,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,dose_or_regimen_context,string,5,3,dose_response | subcutaneous_10mgkg | continued_HFD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,inflammation_score_proxy,float,5,5,0.2 | 0.3 | 0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,liver_homeostasis_benefit_score_proxy,float,5,5,0.55 | 0.6 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,model_system,string,5,5,primary_mouse_hepatocytes | HFD_mouse_liver | HFD_mouse_MASLD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,modeling_role,string,5,5,in_vitro_target_engagement | in_vivo_hepatocyte_target_engagement | steatosis_reversal_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,module_id,categorical,5,1,GalNAc_siCEBPB_MASLD_liver_homeostasis,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,notes,categorical,5,1,Generated scenario row; proxy values enc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,oligo_modality,categorical,5,1,GalNAc_conjugated_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,provenance_label,categorical,5,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,safety_interpretation,categorical,5,1,unchanged_ALT_AST_no_hepatotoxicity_sign,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,scenario_id,string,5,5,PMH_dose_response_0_001_to_5uM | HFD_mouse_SC_10mgkg_target_knockdown | HFD_mouse_steatosis_reduction,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,source_id,categorical,5,1,KHORSANDI_GALNAC_SICEBPB_MASLD_HOMEOSTAS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,steatosis_score_proxy,float,5,5,0.2 | 0.35 | 0.25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,study_context,categorical,5,2,in_vitro | in_vivo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,target_gene,categorical,5,1,CEBPB,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicebpb_masld_liver_homeostasis.csv,value_origin,categorical,5,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,CIDEB_knockdown_score_proxy,float,6,6,0.92 | 0.94 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,MASH_steatosis_or_fibrosis_benefit_score_proxy,float,6,4,0.55 | 0.74 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,assumption_id,categorical,6,1,ASM_080,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,challenge_alignment,categorical,6,1,directly supports ability-to-solve and i,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,chemical_design_features,categorical,6,1,2prime-OMe|2prime-F|5prime-VP|isoGNA_spe,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,dose_or_regimen_context,string,6,5,screening | GalNAc_modified | ASGPR_free_uptake,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,model_system,string,6,5,Hep3B | primary_mouse_hepatocytes | AAV8_hCIDEB_mouse_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,modeling_role,string,6,6,initial_sequence_screen | lead_candidate_screen | cross_species_hepatocyte_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,module_id,categorical,6,1,GalNAc_siCIDEB_MASH_safety_efficacy,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,notes,categorical,6,1,Generated scenario row; proxy values enc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,observed_toxicity_score_proxy,float,6,5,0.2 | 0.16 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,offtarget_assessment_included,categorical,6,1,yes_transcriptome_or_reporter_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,oligo_modality,categorical,6,1,GalNAc_conjugated_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,residual_inflammation_or_liver_stress_score_proxy,float,6,5,0.3 | 0.24 | 0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,safety_interpretation,categorical,6,2,disease_model_residual_stress_context | minimal_offtarget_and_no_observed_toxici,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,scenario_id,string,6,6,screening_Hep3B_unconjugated_siRNA | modified_GalNAc_siCIDEB_Hep3B | primary_mouse_hepatocyte_free_uptake,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,source_id,categorical,6,1,LIN_GALNAC_SICIDEB_MASH_STEATOSIS_FIBROS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,study_context,categorical,6,2,in_vitro | in_vivo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,target_gene,categorical,6,1,CIDEB,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,target_specificity_score_proxy,float,6,5,0.65 | 0.78 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sicidEB_mash_safety.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,analyte,categorical,150,5,Givosiran | Givosiran_AS_Nminus1_3prime_metabolite | Lumasiran,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,bioanalysis_quality_class_generated,categorical,150,3,robust_generalizable | sequence_specific_or_costly | needs_optimization,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,cost_complexity_score_proxy,float,150,3,0.25 | 0.65 | 0.85,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,judging_alignment,categorical,150,1,Feasibility_and_Rigor|Transparency_and_R,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,lcms_platform,categorical,150,1,QTRAP_MRM_or_Orbitrap_HRMS_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,lloq_ng_per_mL_proxy,float,150,150,3.19469 | 4.12879 | 3.99932,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,matrix_interference_score_proxy,float,150,150,0.12336 | 0.13228 | 0.05311,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,modeling_value,categorical,150,1,measurement_quality_PK_TK_reproducibilit,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,module_record_id,identifier,150,150,GALNAC_LCMS_0001 | GALNAC_LCMS_0002 | GALNAC_LCMS_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,parent_metabolite_discrimination_flag,integer,150,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,pk_parameter_suitability_score_proxy,float,150,103,0.98747 | 0.9771 | 0.98976,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,precision_cv_proxy,float,150,150,0.09024 | 0.09879 | 0.13341,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,recovery_fraction_proxy,float,150,150,0.74192 | 0.71689 | 0.71235,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,sample_matrix,categorical,150,2,rat_plasma | human_plasma_proxy,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,sample_preparation_method,categorical,150,3,DPPT_optimized_ACN | SPE_context | hybridization_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,source_id,categorical,150,1,KIM_GALNAC_SIRNA_LCMS_DPPT_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_lcms_bioanalysis.csv,value_origin,categorical,150,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,oligo_id,string,319,319,CTRL_OLIGO_NEG_SPHEROID_TOLERATED | CTRL_OLIGO_POS_HIGH_OFFTARGET | CTRL_OLIGO_POS_TRANSCRIPTOMIC_STRESS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,control_id,string,319,25,CTRL_NEG_HUMAN_LIVER_SPHEROID_TOLERATED | CTRL_POS_HIGH_OFFTARGET | CTRL_POS_TRANSCRIPTOMIC_STRESS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,source_id,string,319,58,LIVER_SPHEROID_SCHOLTEN_2026 | MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RO7239958_GERETTI_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,target_gene,string,319,67,AHSA1 | generic_offtarget | generic_stress_pathway,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,modality,string,319,31,GalNAc-siRNA | siRNA | gapmer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,cell_model,string,319,31,human_liver_spheroid | HepaRG | clinical_liver_readout_proxy,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,galnac_sirna_nonclinical_context_flag,integer,319,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,galnac_sirna_safety_state,categorical,319,5,distribution_accumulation_liver_kidney_R | rat_sensitive_exaggerated_dose_screen | seed_region_offtarget_rat_hepatotoxicity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,ESC_chemistry_context_flag,integer,319,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,ASGPR_hepatocyte_receptor_capacity_proxy,float,319,269,0.9059 | 0.9746 | 0.9503,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,extrahepatic_distribution_fraction_proxy,float,319,242,0.0164 | 0.0 | 0.0129,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,terminal_PS_linkage_count_proxy,integer,319,1,4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,two_prime_OMe_full_modification_context,integer,319,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,two_prime_F_modification_context,integer,319,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,supratherapeutic_dose_multiple_proxy,integer,319,6,180.0 | 30.0 | 60.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,rat_hepatotoxicity_sensitivity_score_proxy,float,319,304,0.5943 | 0.5322 | 0.6673,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,monkey_adversity_score_proxy,float,319,308,0.3056 | 0.1073 | 0.3867,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,seed_region_offtarget_hepatotoxicity_risk_proxy,float,319,290,0.0463 | 0.1305 | 0.2295,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,seed_region_destabilization_mitigation_applicable,integer,319,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,centrilobular_degeneration_necrosis_score_proxy,float,319,290,0.1815 | 0.2091 | 0.2952,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,ALT_fold_ULN_exaggerated_dose_proxy,float,319,316,1.4791 | 1.4128 | 1.2725,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,kidney_elimination_accumulation_score_proxy,float,319,298,0.6186 | 0.151 | 0.3023,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,renal_function_change_score_proxy,float,319,94,0.1115 | 0.0 | 0.0008,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,RES_lymph_node_macrophage_accumulation_score_proxy,float,319,287,0.4056 | 0.0 | 0.1784,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,partial_complete_reversibility_score_proxy,float,319,304,0.6203 | 0.6824 | 0.6564,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,genotoxicity_negative_context_flag,integer,319,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,safety_pharmacology_negative_context_flag,integer,319,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,galnac_sirna_platform_safety_modifier,float,319,308,0.2112 | 0.1945 | 0.2843,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,galnac_sirna_platform_safety_label,categorical,319,3,selected_low_tox_platform_profile | seed_offtarget_hepatotox_screen_fail | distribution_monitoring_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,value_origin,categorical,319,1,literature_grounded_generated_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,assumption_id,categorical,319,1,ASM_034,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_nonclinical_safety.csv,record_origin,categorical,319,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,assumption_id,categorical,6,1,ASM_110,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,delivery_or_targeting_score_proxy,float,6,6,0.96 | 0.9 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,mechanism_or_specificity_score_proxy,float,6,4,0.88 | 0.9 | 0.92,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,modality_or_platform,string,6,5,GalNAc-siRNA | modified_GalNAc-siRNA | GalNAc-siRNA_design,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,model_system,string,6,6,rat_supratherapeutic_toxicology | rat_mouse_hepatotoxicity_rescue | liver_concentration_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,modeling_role,string,6,6,direct_ALT_AST_bilirubin_and_histopathol | RISC_loading_required_but_not_sufficient | chemistry_and_exposure_not_primary_drive,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,module_id,categorical,6,1,GalNAc_siRNA_seed_offtarget_rat_hepatoto,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,primary_effect_score_proxy,float,6,6,0.92 | 0.82 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,scenario_id,string,6,6,hepatotoxic_GalNAc_siRNA_repeat_dose_scr | antisense_5prime_capping_blocks_RISC_loa | liver_exposure_matched_RISC_inactive_con,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,source_id,categorical,6,1,JANAS_GALNAC_SIRNA_OFFTARGET_RAT_HEPATOT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,toxicity_or_safety_signal_proxy,float,6,5,0.44 | 0.18 | 0.14,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_offtarget_rat_hepatotoxicity.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,assumption_id,categorical,6,1,ASM_123,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,delivery_or_targeting_score_proxy,float,6,5,0.92 | 0.88 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,mechanism_or_specificity_score_proxy,float,6,4,0.88 | 0.9 | 0.92,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,modality_or_platform,string,6,6,GalNAc_siRNA_PK_mechanism | PK_PD_mechanism | modeling_rigor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,model_system,string,6,6,whole_body_PBPK_hepatocyte_ASGPR_model | GalNAc_siRNA_RISC_mRNA_target_protein_mo | cross_species_PK_PD_translation_framewor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,modeling_role,string,6,6,liver_specific_uptake_and_ASGPR_transpor | RISC_mRNA_knockdown_target_protein_PD_co | preclinical_to_clinical_translation_cont,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,module_id,categorical,6,1,GalNAc_siRNA_whole_body_PBPK_PD_species_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,primary_effect_score_proxy,float,6,5,0.84 | 0.82 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,scenario_id,string,6,6,ASGPR_hepatocyte_targeted_uptake | endosomal_escape_RISC_loading_PD | mouse_monkey_human_species_translation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,source_id,categorical,6,1,SALIM_GALNAC_SIRNA_WB_PBPK_PD_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,toxicity_or_safety_signal_proxy,float,6,4,0.24 | 0.22 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pbpk_pd_species_translation.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,assumption_id,categorical,6,1,ASM_107,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,delivery_or_targeting_score_proxy,float,6,6,0.32 | 0.3 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,mechanism_or_specificity_score_proxy,float,6,5,0.88 | 0.76 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,modality_or_platform,string,6,5,siRNA_design | siRNA | GalNAc-siRNA_comparator,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,model_system,string,6,6,PCSK9_mRNA_candidate_library | HEK293T_reporter_model | PCSK9_positive_control_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,modeling_role,string,6,6,sequence_design_and_offtarget_prediction | initial_activity_screening_context | approved_like_comparator_anchor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,module_id,categorical,6,1,GalNAc_siRNA_PCSK9_design_and_synthesis,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,primary_effect_score_proxy,float,6,6,0.76 | 0.78 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,scenario_id,string,6,6,in_silico_siRNA_candidate_selection | unmodified_siRNA_screening | Inclisiran_analog_comparator,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,source_id,categorical,6,1,DMITRIEV_GALNAC_SIRNA_PCSK9_LIQUID_PHASE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,toxicity_or_safety_signal_proxy,float,6,3,0.16 | 0.18 | 0.24,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_pcsk9_liquid_phase_design.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,assumption_id,categorical,7,1,ASM_124,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,hepatotoxicity_signal_score_proxy,float,7,7,0.4 | 0.92 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,mechanistic_role,string,7,7,on_target_catalytic_cleavage | seed_off_target_miRNA_like_repression | control_ARGONAUTE_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,modeled_readout_family,categorical,7,1,ALT_AST_liver_function_tests_transcripto,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,module_id,categorical,7,1,GalNAc_siRNA_RISC_offtarget_hepatotoxici,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,notes,string,7,7,AGO2 knockdown reduces intended GalNAc-s | AGO2 is modeled as a major mediator of u | AGO1/AGO4 knockdown is modeled as less p,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,off_target_activity_dependency_score_proxy,float,7,7,0.9 | 0.88 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,on_target_activity_dependency_score_proxy,float,7,7,0.95 | 0.86 | 0.25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,protective_knockdown_or_mitigation_score_proxy,float,7,7,0.3 | 0.72 | 0.16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,risc_component_or_feature,string,7,6,AGO2 | AGO1_AGO4 | TNRC6A_TNRC6B,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,scenario_id,string,7,7,AGO2_on_target_requirement | AGO2_off_target_hepatotoxicity_requireme | AGO1_AGO4_not_primary_protective,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,source_id,categorical,7,1,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
galnac_sirna_risc_offtarget_mechanism.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,ALT_AST_liability_fold_proxy,float,6,6,3.8 | 3.1 | 1.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,RNase_H1_dependency,string,6,3,yes | attenuated_by_RNaseH1_knockdown | yes_but_sequence_selective,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,affinity_modification,string,6,3,LNA | cEt | 2-MOE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,challenge_alignment,categorical,6,1,"directly supports ability-to-solve, rigo",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,gapmer_length_nt_proxy,integer,6,1,16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,high_affinity_modification_flag,integer,6,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,intended_target_context,categorical,6,1,F7_F11_SOD1_PTEN_BIRC5_style_mouse_or_hu,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,long_transcript_susceptibility_proxy,float,6,6,0.78 | 0.7 | 0.19,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,module_id,categorical,6,1,gapmer_RNaseH1_long_pre_mRNA_hepatotoxic,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,notes,categorical,6,1,Generated mechanism row; does not reprod,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,oligo_class,categorical,6,1,RNase_H_gapmer_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,pre_mRNA_length_enrichment_bin,string,6,3,very_long | mixed | short_to_mid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,scenario_id,string,6,6,LNA_high_affinity_toxic | cEt_high_affinity_toxic | MOE_gapmer_lower_liability,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,scenario_role,string,6,4,positive_control | negative_comparator | mechanistic_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,source_id,categorical,6,1,BUREL_GAPMER_RNASEH1_LONG_PREMRNA_HEPATO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,transcriptome_selectivity_index_proxy,float,6,6,0.18 | 0.24 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,transcriptomic_signature_timing,categorical,6,2,source_grounded_mechanism_proxy | concurrent_with_on_target_reduction_and_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,very_long_pre_mRNA_offtarget_reduction_proxy,float,6,6,0.82 | 0.76 | 0.24,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gapmer_rnaseh1_long_premrna_hepatotox.csv,wing_design_proxy,categorical,6,2,3-10-3 high affinity wings | MOE gapmer comparator,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
generated_records.csv,generated_record_id,string,17920,17920,GEN_CTRL_OLIGO_NEG_VEHICLE_MOCK | GEN_CTRL_OLIGO_NEG_LOW_RISK | GEN_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Aggregate counts and provenance summary of generated records by table.
generated_records.csv,record_type,categorical,17920,2,oligo_level_record | toxicity_readout_record,Aggregate counts and provenance summary of generated records by table.
generated_records.csv,primary_id,string,17920,17920,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Aggregate counts and provenance summary of generated records by table.
generated_records.csv,source_id,string,17920,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Aggregate counts and provenance summary of generated records by table.
generated_records.csv,control_id,string,17920,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Aggregate counts and provenance summary of generated records by table.
generated_records.csv,record_origin,categorical,17920,1,dbbun_generated,Aggregate counts and provenance summary of generated records by table.
generated_records.csv,value_origin,categorical,17920,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Aggregate counts and provenance summary of generated records by table.
generated_records.csv,measured_experimental_value,categorical,17920,1,no,Aggregate counts and provenance summary of generated records by table.
generated_records.csv,license_for_generated_output,categorical,17920,1,CC BY 4.0,Aggregate counts and provenance summary of generated records by table.
gys1_aso_pompe_skeletal_muscle.csv,assumption_id,categorical,6,1,ASM_115,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,delivery_or_targeting_score_proxy,float,6,6,0.62 | 0.6 | 0.58,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,mechanism_or_specificity_score_proxy,float,6,6,0.88 | 0.82 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,modality_or_platform,string,6,6,PS-cEt_gapmer_ASO | ASO_substrate_reduction | ASO_plus_enzyme_replacement,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,model_system,string,6,6,Gaa_knockout_mouse_skeletal_muscle | Pompe_myopathy_mouse_model | combination_therapy_mouse_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,modeling_role,string,6,6,extrahepatic_ASO_target_knockdown_contex | tissue_function_response_context | combination_intervention_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,module_id,categorical,6,1,GYS1_ASO_Pompe_skeletal_muscle_effects,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,primary_effect_score_proxy,float,6,6,0.82 | 0.84 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,scenario_id,string,6,6,systemic_Gys1_gapmer_ASO_knockdown | skeletal_muscle_glycogen_reduction | ERT_ASO_combination,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,source_id,categorical,6,1,WEISS_GYS1_ASO_POMPE_SKELETAL_MUSCLE_202,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,toxicity_or_safety_signal_proxy,float,6,3,0.24 | 0.22 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_aso_pompe_skeletal_muscle.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,oligo_id,string,4,4,OLIGO_CTRL_NEG_GYS1_ASO_NO_ALT_AST_ELEVA | OLIGO_CTRL_CONTEXT_GYS1_ASO_SUBSTRATE_RE | OLIGO_CTRL_CONTEXT_GYS1_ASO_ERT_COMBINAT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,source_id,categorical,4,1,WEISS_GYS1_ASO_POMPE_PREPRINT_2024,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,control_id,string,4,4,CTRL_NEG_GYS1_ASO_NO_ALT_AST_ELEVATION | CTRL_CONTEXT_GYS1_ASO_SUBSTRATE_REDUCTIO | CTRL_CONTEXT_GYS1_ASO_ERT_COMBINATION,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,gys1_pompe_state,string,4,4,Gys1_ASO_systemic_tolerability_low_ALT_A | Pompe_Gys1_substrate_reduction_ASO | Pompe_Gys1_ASO_plus_ERT_combination,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,therapy_context,string,4,3,GYS1_ASO_alone | GYS1_ASO_plus_rhGAA_ERT | specificity_screening_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,treatment_timing_context,string,4,4,preclinical_systemic_ASO_tolerability | early_or_reversal_treatment_context | combination_after_ASO_lead_in,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,aso_gapmer_length_nt,integer,4,1,16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,aso_backbone,categorical,4,1,phosphorothioate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,aso_sugar_modification,categorical,4,1,2prime_constrained_ethyl_cEt,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,gapmer_architecture,categorical,4,1,3_10_3_cEt_gapmer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,RNase_H1_mechanism_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,subcutaneous_weekly_dosing_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,dose_mg_kg_week_proxy,integer,4,1,25.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,treatment_duration_weeks_proxy,integer,4,1,16.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,ERT_combination_flag,integer,4,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,rhGAA_ERT_context_flag,integer,4,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,Gys1_mRNA_knockdown_fraction_proxy,float,4,4,0.86 | 0.82 | 0.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,GYS1_protein_reduction_fraction_proxy,float,4,4,0.94 | 0.9 | 0.98,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,GYS1_GYS2_isoform_specificity_score_proxy,float,4,4,0.8 | 0.784 | 0.81,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,GYS2_liver_spared_score_proxy,float,4,3,0.8808 | 0.8779 | 0.8845,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,quadriceps_glycogen_reduction_fraction_proxy,float,4,4,0.55 | 0.48 | 0.83,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,heart_glycogen_reduction_fraction_proxy,float,4,4,0.531 | 0.5016 | 0.8286,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,autophagy_marker_rescue_score_proxy,float,4,4,0.5575 | 0.512 | 0.8395,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,LAMP1_LC3_p62_rescue_context_score_proxy,float,4,4,0.5575 | 0.512 | 0.8395,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,motor_function_preservation_score_proxy,float,4,4,0.5505 | 0.511 | 0.804,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,ALT_fold_proxy,float,4,3,1.0 | 1.03 | 1.02,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,AST_fold_proxy,float,4,3,1.0 | 1.03 | 1.02,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,BUN_fold_proxy,float,4,2,1.0 | 1.01,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,CK_fold_proxy,float,4,4,1.02 | 0.92 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,organ_weight_change_abs_proxy,float,4,4,0.04 | 0.06 | 0.05,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,systemic_tolerability_score_proxy,float,4,4,0.95 | 0.9336 | 0.944,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,ALT_AST_safety_monitoring_score_proxy,float,4,3,1.0 | 0.985 | 0.99,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,preprint_caution_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,direct_oligotox_hepatotoxicity_relevance,categorical,4,1,supporting_not_direct,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,phase2_alignment,categorical,4,1,experimental_design_negative_controls_tr,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,confidence_score,float,4,4,0.58 | 0.56 | 0.57,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
gys1_pompe_aso_srt_context.csv,assumption_id,categorical,4,1,ASM_040,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_state,categorical,1120,4,baseline_non_HBV_RNAi_context | VIR2218_ESCplus_seed_modified_low_ALT_or | ALN_HBV_parent_seed_offtarget_ALT_elevat,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_therapeutic_context,categorical,1120,4,not_applicable | VIR-2218_ESCplus_healthy_volunteer | ALN-HBV_parent_ESC,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_target_region,categorical,1120,2,not_applicable | HBV_X_DR2_region_all_major_transcripts,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_ESCplus_seed_modification,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_gna_seed_substitution,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_seed_mediated_offtarget_reduction_score,float,1120,19,0.0 | 0.92625 | 0.02781,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_predicted_offtarget_gene_dysregulation_score,float,1120,15,0.0 | 0.02441 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_humanized_mouse_hALT_signal_proxy,float,1120,19,0.0 | 45.6359 | 97.93101,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_healthy_volunteer_ALT_elevation_pct_proxy,float,1120,8,0.0 | 28.0 | 24.47401,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_highest_ALT_xULN_proxy,float,1120,19,1.0 | 1.27008 | 7.20565,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_ALT_no_bilirubin_functional_impairment_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_clinical_dose_mg_proxy,integer,1120,7,0.0 | 100.0 | 200.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_dose_mg_per_kg_proxy,float,1120,14,0.0 | 1.56127 | 3.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_number_of_doses_proxy,integer,1120,3,0 | 1 | 2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_dosing_interval_weeks_proxy,integer,1120,2,0.0 | 4.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_HBsAg_reduction_week20_log10_proxy,float,1120,7,0.0 | -1.88006 | -0.47728,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_HBsAg_reduction_week48_log10_proxy,float,1120,7,0.0 | -1.04078 | -0.07665,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_HBsAg_below_100_IU_ml_probability_proxy,float,1120,3,0.0 | 0.7 | 0.25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_functional_cure_observed_flag,integer,1120,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_safety_modifier,float,1120,17,0.0 | -0.47282 | 1.75,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_antiviral_activity_score,float,1120,7,0.0 | 1.05 | 0.28926,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,hbv_rnai_confidence_score,float,1120,19,0.0 | 0.84624 | 0.69747,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,context_note,categorical,1120,3,not_applicable | VIR-2218/ALN-HBV generated proxy fields  | HBV RNAi ESC+ seed-region context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,value_origin,categorical,1120,3,not_reported | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hbv_rnai_escplus_safety.csv,license_for_generated_output,categorical,1120,1,CC BY 4.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,oligo_id,string,3,3,OLIGO_CTRL_NEG_HNP_SIHOXB7_LOW_HEPATIC_S | OLIGO_CTRL_CONTEXT_HOXB7_SIRNA_TAMOXIFEN | OLIGO_CTRL_CONTEXT_HNP_CALCIUM_PHOSPHATE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,source_id,categorical,3,1,VALLE_HOXB7_HNP_TAMOXIFEN_BREAST_2024,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,control_id,string,3,3,CTRL_NEG_HNP_SIHOXB7_LOW_HEPATIC_SIGNAL | CTRL_CONTEXT_HOXB7_SIRNA_TAMOXIFEN_COTRE | CTRL_CONTEXT_HNP_CALCIUM_PHOSPHATE_ENDOS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,target_gene,categorical,3,1,HOXB7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,oligo_modality,categorical,3,1,siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,hnp_hoxb7_state,string,3,3,HNP_siHOXB7_low_hepatic_signal | HOXB7_siRNA_tamoxifen_cotreatment | calcium_phosphate_HNP_siRNA_delivery_con,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,breast_cancer_context_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,calcium_phosphate_hybrid_nanoparticle_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,PEG_pGlu_shell_context_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,HOXB7_siRNA_payload_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,tamoxifen_cotreatment_flag,integer,3,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,mean_hydrodynamic_diameter_nm_proxy,float,3,2,74.4 | 70.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,PDI_proxy,float,3,2,0.1 | 0.07,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,zeta_potential_mV_proxy,float,3,1,-1.16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,siRNA_encapsulation_efficiency_pct_proxy,float,3,1,52.5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,acidic_pH_destabilization_flag,integer,3,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,endosomal_escape_context_score,float,3,1,0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,hemolysis_pct_proxy,float,3,2,0.4 | 0.5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,MCF7_viability_48h_pct_proxy,float,3,1,85.7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,migration_free_area_48h_pct_proxy,integer,3,1,52.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,advanced_tumor_survival_pct_proxy,integer,3,3,80.0 | 100.0 | 85.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,advanced_tumor_control_score_proxy,float,3,3,0.66 | 0.78 | 0.55,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,HOXB7_mRNA_expression_pct_of_control_proxy,integer,3,3,50.0 | 68.0 | 72.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,ALT_U_L_proxy,float,3,3,60.4 | 55.7 | 58.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,AST_U_L_proxy,float,3,3,218.0 | 175.5 | 190.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,WBC_systemic_tolerability_context_score,float,3,2,0.72 | 0.55,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,hepatotoxicity_safety_context_label,categorical,3,1,low_direct_hepatic_signal_supporting_con,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,hnp_hoxb7_context_confidence_score,float,3,1,0.77,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,assumption_id,categorical,3,1,ASM_030,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnp_hoxb7_tamoxifen_nanoparticle_context.csv,record_origin,categorical,3,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,administration_context,string,5,4,systemic | systemic_in_vivo_screen | systemic_PDX_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,assumption_id,categorical,5,1,ASM_086,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,challenge_alignment,categorical,5,1,supports delivery and biodistribution ri,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,delivery_related_toxicity_signal_proxy,float,5,4,0.22 | 0.2 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,formulation_or_screen,string,5,3,standard_LNP_reference | DNA_barcoded_LNP_library | LNPHNSCC,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,in_vivo_screening_relevance_score_proxy,float,5,4,0.7 | 0.78 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,liver_detargeting_context,categorical,5,2,no_or_reference | yes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,liver_hepatocyte_delivery_score_proxy,float,5,5,0.85 | 0.55 | 0.35,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,modeling_role,string,5,5,liver_offtarget_reference | high_throughput_discovery_context | tumor_delivery_liver_detargeting_candida,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,module_id,categorical,5,1,hnscc_lnp_liver_detargeting,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,notes,categorical,5,1,Generated delivery-biodistribution scena,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,payload_context,categorical,5,1,mRNA_or_barcoded_nucleic_acid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,provenance_label,categorical,5,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,scenario_id,string,5,5,standard_liver_tropic_LNP | barcoded_94_LNP_in_vivo_screen | LNPHNSCC_tumor_tropic,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,source_id,categorical,5,1,HUAYAMARES_HNSCC_LNP_TUMOR_TROPISM_LIVER,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,tumor_delivery_score_proxy,float,5,5,0.35 | 0.55 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hnscc_lnp_liver_detargeting.csv,value_origin,categorical,5,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_genetics_aso_translation.csv,assumption_id,categorical,7,1,ASM_127,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_genetics_aso_translation.csv,endpoint_family,string,7,7,ALT_AST | ALD_NAFLD_cirrhosis | NASH_histology,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_genetics_aso_translation.csv,evidence_confidence_score_proxy,float,7,6,0.82 | 0.84 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_genetics_aso_translation.csv,model_system,string,7,6,human_genetics | human_EHR_exome_cohorts | human_liver_samples,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_genetics_aso_translation.csv,module_id,categorical,7,1,HSD17B13_genetics_ASO_translation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_genetics_aso_translation.csv,notes,string,7,7,loss_of_function_variant_associated_with | protective_association_across_chronic_li | variant_associated_with_reduced_NASH_ris,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_genetics_aso_translation.csv,protective_or_target_rationale_score_proxy,float,7,6,0.86 | 0.84 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_genetics_aso_translation.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_genetics_aso_translation.csv,scenario_id,string,7,7,HSD17B13_rs72613567_TA_ALT_AST_lower | reduced_chronic_liver_disease_risk | NASH_not_steatosis_histology_distinction,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_genetics_aso_translation.csv,source_id,categorical,7,2,ABULHUSN_HSD17B13_PROTECTIVE_VARIANT_201 | MA_HSD17B13_ASO_FIBROSIS_MOUSE_2024,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_genetics_aso_translation.csv,toxicity_or_limitation_score_proxy,float,7,5,0.12 | 0.1 | 0.24,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_genetics_aso_translation.csv,translation_relevance_score_proxy,float,7,6,0.76 | 0.8 | 0.7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_genetics_aso_translation.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,hsd17b13_clinical_state,categorical,1120,7,baseline_non_HSD17B13_clinical_context | MASH_400mg_highest_dose_max_mRNA_knockdo | healthy_adult_single_ascending_dose_PK_s,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,hsd17b13_genotype_context,categorical,1120,4,not_applicable | no_homozygous_protective_variant | risk_allele_carrier_or_unknown,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,hsd17b13_risk_allele_status,categorical,1120,4,not_applicable | HSD17B13_risk_allele_present_or_unknown | heterozygous_protective_possible,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,pnpla3_rs738409_context,categorical,1120,4,not_applicable | PNPLA3_risk_status_balanced | PNPLA3_I148M_risk_allele_possible,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_like_dose_mg_proxy,integer,1120,6,0.0 | 400.0 | 200.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_number_of_doses_proxy,integer,1120,3,0 | 2 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_dosing_interval_weeks_proxy,integer,1120,2,0.0 | 12.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_route,categorical,1120,2,not_applicable | subcutaneous,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_ASGPR_GalNAc_delivery_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_HSD17B13_mRNA_change_month6_pct_proxy,float,1120,77,0.0 | -81.88884 | -70.27332,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_HSD17B13_mRNA_change_month12_pct_proxy,float,1120,36,0.0 | -28.54278 | -2.6684,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_ALT_change_day169_pct_proxy,float,1120,90,0.0 | -23.55218 | -4.41809,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_AST_change_day169_pct_proxy,float,1120,90,0.0 | -10.11747 | -4.6387,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_no_DILI_observed_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_injection_site_reaction_pct_proxy,integer,1120,3,0.0 | 6.0 | 11.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_ADA_incidence_pct_proxy,float,1120,3,0.0 | 2.8 | 2.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_NAS_change_direction_proxy,categorical,1120,6,not_applicable | numerically_improved_NAS_lobular_inflamm | not_applicable_healthy_adult,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_lobular_inflammation_ballooning_improvement_proxy,float,1120,67,0.0 | 0.33152 | -0.1682,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_fibrosis_stage_improvement_proxy,float,1120,69,0.0 | 0.48817 | 0.02754,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_Tmax_hours_proxy,float,1120,76,0.0 | 4.2037 | 5.41745,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_plasma_half_life_hours_proxy,float,1120,76,0.0 | 4.49061 | 6.59521,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_parent_urine_excretion_pct_proxy,float,1120,76,0.0 | 24.50557 | 32.36374,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_active_metabolite_urine_excretion_pct_proxy,float,1120,76,0.0 | 1.53607 | 0.61222,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_ASGPR_saturation_context,categorical,1120,4,not_applicable | transient_ASGPR_saturation_possible_high | ASGPR_mediated_hepatocyte_uptake,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_PD_durability_score_proxy,float,1120,74,0.0 | 0.81889 | 0.40617,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_clinical_safety_modifier,float,1120,6,0.0 | -0.54 | -0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_clinical_benefit_modifier,float,1120,41,0.0 | 0.81889 | 0.04,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,rapirosiran_clinical_confidence_score,float,1120,87,0.0 | 0.90878 | 0.78454,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,context_note,categorical,1120,3,HSD17B13/rapirosiran clinical context no | rapirosiran/HSD17B13 clinical PK-PD safe | HSD17B13/rapirosiran clinical context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hsd17b13_rapirosiran_clinical_pd.csv,license_for_generated_output,categorical,1120,1,CC BY 4.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,assumption_id,categorical,6,1,ASM_113,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,delivery_or_targeting_score_proxy,float,6,5,0.84 | 0.82 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,mechanism_or_specificity_score_proxy,float,6,5,0.78 | 0.74 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,modality_or_platform,string,6,6,nebulized_siRNA_HNP | delivery_physics_context | biomimetic_LNP_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,model_system,string,6,6,pulmonary_fibrosis_mouse_lung | fibrotic_airway_mucus_barrier | alveolar_macrophage_targeting,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,modeling_role,string,6,6,extrahepatic_siRNA_delivery_breadth | barrier_penetration_modeling_context | macrophage_affinity_and_delivery_specifi,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,module_id,categorical,6,1,nebulized_HNP_TGFb1_siRNA_pulmonary_fibr,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,primary_effect_score_proxy,float,6,6,0.8 | 0.66 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,scenario_id,string,6,6,aerosol_HNP_TGFb1_siRNA_delivery | hydrogen_mucus_barrier_disruption | apoptotic_T_cell_membrane_biomimetic_tar,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,source_id,categorical,6,1,LIU_HYDROGEN_HNP_TGFB1_SIRNA_PULMONARY_F,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,toxicity_or_safety_signal_proxy,float,6,3,0.2 | 0.18 | 0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
hydrogen_hnp_tgfb1_sirna_pulmonary_fibrosis.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,oligo_id,identifier,44,44,OLIGO_0000010 | OLIGO_0000024 | OLIGO_0000041,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,control_id,categorical,44,5,NON_CONTROL_GENERATED_RECORD | CTRL_POS_IFNA_DISULFIDPTOSIS_HCC | CTRL_NEG_DPEN_DISULFIDPTOSIS_RESCUE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,source_id,categorical,44,20,BI_IFNA_DISULFIDPTOSIS_HCC_2026 | KIM_NANP_LIPID_LIVER_TARGETING_2026 | BOSCO_INCLISIRAN_FH_REALWORLD_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,target_gene,string,44,30,CYP2E1 | APOB | PSMD9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,modality,categorical,44,20,DCA_conjugated_asymmetric_siRNA | GalNAc-siRNA | GalNAc-LNA-ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,cell_model,categorical,44,12,liver_on_chip | HepG2 | rat_primary_hepatocytes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,ifna_disulfidptosis_context_flag,integer,44,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,ifna_disulfidptosis_state,categorical,44,5,IFN_alpha_disulfidptosis_like_HCC_stress | background | IFN_alpha_candidate_ISG_upregulation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,hcc_cell_line_context,categorical,44,5,generated_liver_context | HepG2 | IFN_alpha_treated_HepG2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,ifna_concentration_IU_ml_proxy,integer,44,4,1000.0 | 500.0 | 250.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,ifna_duration_h_proxy,integer,44,3,48.0 | 72.0 | 24.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,glucose_availability_state,categorical,44,2,glucose_starvation_or_glucose_uptake_lim | standard_glucose,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,high_molecular_weight_protein_aggregation_score_proxy,float,44,44,0.7346 | 0.7778 | 0.8879,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,disulfide_bond_accumulation_score_proxy,float,44,44,0.7346 | 0.7778 | 0.8879,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,NADPH_depletion_score_proxy,float,44,44,0.7666 | 0.8248 | 0.6893,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,F_actin_collapse_score_proxy,float,44,42,0.5946 | 0.791 | 0.7048,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,D_penicillamine_rescue_score_proxy,float,44,43,0.0637 | 0.2322 | 0.2098,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,apoptosis_necroptosis_contribution_score_proxy,float,44,44,0.4434 | 0.3306 | 0.3244,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,z_vad_nec1_disulfide_rescue_flag,integer,44,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,SLC7A11_expression_response,categorical,44,3,IFN_alpha_upregulated_context | not_modeled | IFN_alpha_upregulated_but_knockdown_did_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,SLC7A11_knockdown_aggravation_score_proxy,float,44,44,0.3298 | 0.236 | 0.2918,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,B2M_upregulation_score_proxy,float,44,43,0.4092 | 0.4653 | 0.3845,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,USP18_upregulation_score_proxy,float,44,43,0.3303 | 0.3254 | 0.2616,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,PSME1_upregulation_score_proxy,float,44,43,0.3151 | 0.5025 | 0.5037,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,PSME1_protein_upregulation_flag,integer,44,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,disulfidptosis_relevance_modifier,float,44,44,0.7022 | 0.7959 | 0.7734,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,direct_oligotox_relevance_modifier,float,44,2,0.3 | 0.05,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,context_confidence_score,float,44,2,0.82 | 0.58,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,value_origin,categorical,44,1,literature_grounded_generated_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,assumption_id,categorical,44,1,ASM_033,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ifna_disulfidptosis_hcc_context.csv,record_origin,categorical,44,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,oligo_id,identifier,33,33,OLIGO_0000041 | OLIGO_0000048 | OLIGO_0000053,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,control_id,categorical,33,3,NON_CONTROL_GENERATED_RECORD | CTRL_CONTEXT_INCLISIRAN_FH_LDL_PWV_RESPO | CTRL_NEG_INCLISIRAN_ALT_AST_STABLE_REALW,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,source_id,categorical,33,11,BOSCO_INCLISIRAN_FH_REALWORLD_2025 | ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022 | HJELMGREN_PS_ASO_DDR_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,target_gene,categorical,33,15,PSMD9 | PCSK9 | RUBICON,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,modality,categorical,33,14,GalNAc-LNA-ASO | high_affinity_gapmer_RNaseH1_toxicity_me | splice-switching_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,cell_model,categorical,33,9,HepG2 | human_liver_spheroid | MelJuSo_DDR_toxicity_screen,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,inclisiran_realworld_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,inclisiran_clinical_state,categorical,33,4,secondary_prevention_response_context | six_month_inclisiran_FH_lipid_PWV_respon | stable_liver_muscle_enzyme_monitoring,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,familial_hypercholesterolemia_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,heterozygous_FH_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,PCSK9_hepatic_mRNA_silencing_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,LDLR_expression_restoration_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,inclisiran_dose_mg_proxy,integer,33,1,284.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,followup_months_proxy,integer,33,1,6.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,LDL_C_change_pct_proxy,float,33,33,-31.3591 | -31.3394 | -49.9518,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,ApoB_change_pct_proxy,float,33,33,-29.8864 | -28.2127 | -30.7554,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,non_HDL_C_change_pct_proxy,float,33,33,-43.7115 | -40.6484 | -38.2947,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,Lp_a_change_pct_proxy,float,33,33,-15.7633 | -17.489 | -16.2495,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,PWV_change_pct_proxy,float,33,33,-17.1142 | -20.5508 | -18.2562,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,LDL_C_target_attainment_probability_proxy,float,33,3,0.231 | 0.41 | 0.59,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,ALT_AST_stability_delta_proxy,float,33,33,0.0814 | 0.0059 | 0.0758,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,CPK_stability_delta_proxy,float,33,33,0.0733 | -0.0202 | 0.021,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,glucose_profile_stable_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,inflammatory_profile_stable_context_flag,integer,33,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,delta_LDL_delta_PWV_association_score_proxy,float,33,25,0.7156 | 0.8587 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,direct_hepatotoxicity_signal_modifier,float,33,33,0.1466 | 0.0107 | 0.1365,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,clinical_tolerability_context_score,float,33,1,0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,value_origin,categorical,33,1,literature_grounded_generated_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,assumption_id,categorical,33,1,ASM_035,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
inclisiran_fh_realworld_context.csv,record_origin,categorical,33,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
information_gap_map.csv,gap_addressed,categorical,144,3,"supporting delivery, mechanism, disease, | direct oligo toxicity or liver-safety re | tracked but not used as a full generatio",Identification of fields where future experimental data would have highest value.
information_gap_map.csv,hepatotoxicity_relevance,string,144,143,governing | supporting_liver_genetics_MASLD_precisio | directly_relevant_clinical_low_DILI_GalN,Identification of fields where future experimental data would have highest value.
information_gap_map.csv,judging_criterion,categorical,144,1,Potential Impact,Identification of fields where future experimental data would have highest value.
information_gap_map.csv,modality_focus,string,144,144,ASO|gapmer|siRNA|GalNAc-siRNA | siRNA|ASO | GalNAc-siRNA|HSD17B13|rapirosiran|MASH|A,Identification of fields where future experimental data would have highest value.
information_gap_map.csv,source_id,string,144,144,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | PNPLA3_ROMEO_VALENTI_2025 | RAPIROSIRAN_SANYAL_2025,Identification of fields where future experimental data would have highest value.
information_gap_map.csv,source_role,string,144,142,governing_schema_and_rules | PNPLA3_precision_genetics_siRNA_ASO_ther | HSD17B13_GalNAc_siRNA_clinical_PK_PD_liv,Identification of fields where future experimental data would have highest value.
information_gap_map.csv,source_title,string,144,142,DBbun OligoTox Phase 2 Alignment Memo | Fifteen Years of PNPLA3: Transforming He | Phase I randomized double-blind study of,Identification of fields where future experimental data would have highest value.
information_gap_map.csv,source_year,integer,144,12,2026 | 2025 | 2023,Identification of fields where future experimental data would have highest value.
information_gap_map.csv,triage_tier,categorical,144,3,supporting | direct | deferred,Identification of fields where future experimental data would have highest value.
information_gap_map.csv,use_in_core_dataset,string,144,52,yes | supporting | yes_core_clinical_PK_PD_safety_module,Identification of fields where future experimental data would have highest value.
information_gap_map.csv,value_origin,categorical,144,1,source_metadata_curated_generated,Identification of fields where future experimental data would have highest value.
kupffer_biomimetic_sirna_srli.csv,ALT_AST_liver_injury_score_proxy,float,6,6,0.88 | 0.91 | 0.49,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,challenge_alignment,categorical,6,1,supports potential impact and delivery r,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,delivery_carrier,string,6,4,none | ZIF-8@siRNA | K-EVs@ZIF-8@siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,inflammatory_cytokine_score_proxy,float,6,6,0.82 | 0.86 | 0.46,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,liver_injury_model,string,6,3,LPS | CLP | mechanism,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,liver_or_Kupffer_targeting_score_proxy,float,6,6,0.08 | 0.07 | 0.48,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,mechanistic_axis,categorical,6,1,BRCC3_NLRP1_inflammasome_pyroptosis_cont,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,modeling_role,string,6,6,injury_positive_context | sepsis_injury_positive_context | siRNA_nanocarrier_effect,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,module_id,categorical,6,1,Kupffer_biomimetic_BRCC3_siRNA_SRLI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,nanoparticle_features,categorical,6,2,ZIF-8_or_no_carrier | K-EV_membrane|ZIF-8|pH_sensitive|siRNA_l,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,notes,categorical,6,1,Generated liver-injury/delivery scenario,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,oligo_modality,categorical,6,1,siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,pyroptosis_inflammasome_score_proxy,float,6,6,0.79 | 0.83 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,scenario_id,string,6,6,LPS_SRLI_untreated | CLP_SRLI_untreated | ZIF8_BRCC3_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,siRNA_target,categorical,6,1,BRCC3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,source_id,categorical,6,1,MA_KUPFFER_BIOMIMETIC_ZIF8_BRCC3_SIRNA_S,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,target_cell_or_compartment,string,6,4,Kupffer_cell_liver | liver_partial_targeting | Kupffer_cell_targeted,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,therapeutic_efficacy_score_proxy,float,6,5,0.1 | 0.5 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
kupffer_biomimetic_sirna_srli.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,assumption_id,categorical,6,1,ASM_108,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,delivery_or_targeting_score_proxy,float,6,6,0.4 | 0.38 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,mechanism_or_specificity_score_proxy,float,6,5,0.92 | 0.88 | 0.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,modality_or_platform,string,6,6,human_single_nucleus_omics | transcriptional_regulation | Dicer substrate siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,model_system,string,6,6,MASH_MetALD_activated_HSCs | TGFb_stimulated_human_HSC | human_HSC_MASH_MetALD_donors,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,modeling_role,string,6,6,human_disease_relevant_fibrosis_expressi | activation_associated_TF_regulation_cont | RNAi_antifibrotic_target_perturbation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,module_id,categorical,6,1,LARP6_HSC_fibrosis_dsiRNA_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,primary_effect_score_proxy,float,6,6,0.7 | 0.68 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,scenario_id,string,6,6,human_MASH_MetALD_HSC_LARP6_upregulation | JUNB_driven_LARP6_activation | LARP6_dsiRNA_knockdown_HSC,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,source_id,categorical,6,1,KIM_LARP6_HSC_FIBROSIS_DSI_RNA_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,toxicity_or_safety_signal_proxy,float,6,4,0.22 | 0.2 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
larp6_hsc_fibrosis_dsirna.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,lipid_homeostasis_id,string,1120,1120,LIPID_CTRL_OLIGO_NEG_VEHICLE_MOCK | LIPID_CTRL_OLIGO_NEG_LOW_RISK | LIPID_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,lipid_export_state,categorical,1120,4,baseline | APOB_ASO_inhibition | combined_lipid_stress,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,mipomersen_like_APOB_ASO,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,apob_inhibition_proxy,float,1120,1008,0.05527 | 0.04932 | 0.06285,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,mttp_activity_suppression_proxy,float,1120,1031,0.0899 | 0.11823 | 0.06286,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,vldl_apob_secretion_proxy,float,1120,1043,0.91702 | 0.91149 | 0.97793,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,vldl_particle_size_nm_proxy,float,1120,6,0.0 | 75.0 | 160.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,oleate_challenge,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,heat_stress_challenge,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,lipid_export_stress_score,float,1120,1038,0.1837 | 0.04995 | 0.15272,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,lipotoxicity_context_label,categorical,1120,3,low | high | moderate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,context_note,categorical,1120,1,supporting lipid-homeostasis / ApoB-ASO ,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_homeostasis.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,oligo_id,identifier,15,15,OLIGO_0000024 | OLIGO_0000045 | OLIGO_0000152,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,control_id,categorical,15,1,NON_CONTROL_GENERATED_RECORD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,source_id,categorical,15,1,KIM_NANP_LIPID_LIVER_TARGETING_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,target_gene,string,15,13,APOB | MKK4 | MYC,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,modality,string,15,12,GalNAc-siRNA | ASO_PNA_BROTHERS_duplex | ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,NANP_DNA_origami_platform_flag,integer,15,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,cholesterol_lipidation_flag,integer,15,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,ligand_valency_proxy,float,15,15,5.56338 | 6.26571 | 6.24451,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,LDLR_SR_B1_engagement_score_proxy,float,15,15,0.72324 | 0.81454 | 0.81179,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,HepG2_hepatocyte_association_score_proxy,float,15,15,0.70469 | 0.79366 | 0.79097,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,Kupffer_macrophage_J774A1_association_score_proxy,float,15,15,0.53779 | 0.60569 | 0.60364,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,hepatocyte_selectivity_index_proxy,float,15,15,0.48216 | 0.54303 | 0.54119,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,siRNA_delivery_benchmark_score_proxy,float,15,15,0.50998 | 0.57436 | 0.57241,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,direct_oligotox_relevance,categorical,15,1,supporting_delivery_cell_type_targeting_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,value_origin,categorical,15,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,assumption_id,categorical,15,1,ASM_047,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lipid_nanp_liver_cell_targeting.csv,hash_proxy,float,15,15,0.04189 | 0.81118 | 0.78546,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,assumption_id,categorical,35,1,ASM_063,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,backbone_class,categorical,35,7,standard_PS_LNA | butyl_LNA_PTTE | hexyl_LNA_PTTE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,cell_toxicity_liability_proxy,float,35,35,0.52083 | 0.50398 | 0.49304,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,challenge_gap_addressed,categorical,35,1,expanded_backbone_chemistry_design_space,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,concentration_uM_proxy,float,35,5,0.5 | 1.0 | 5.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,conjugate_class,categorical,35,4,none_or_alkyl | amino_acid | carbohydrate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,contains_LNA,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,contains_phosphothiotriester,integer,35,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,duplex_stability_score_proxy,float,35,35,0.6195 | 0.65816 | 0.59954,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,estimated_backbone_charge_fraction_proxy,float,35,6,1.0 | 0.45 | 0.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,gymnotic_uptake_activity_proxy,float,35,35,0.06239 | 0.10524 | 0.29586,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,judging_alignment,categorical,35,1,Potential_Impact|Feasibility_and_Rigor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,modality,categorical,35,1,splice_switching_oligonucleotide,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,modeling_value,categorical,35,1,"supports backbone charge, PS reduction/r",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,module_record_id,string,35,35,supplemental_PTTE_standard_PS_LNA_0p5uM | supplemental_PTTE_standard_PS_LNA_1uM | supplemental_PTTE_standard_PS_LNA_5uM,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,predicted_PS_related_protein_binding_liability_proxy,float,35,35,0.67925 | 0.6267 | 0.66385,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,source_id,categorical,35,1,DHARA_LNA_PHOSPHOTHIOTRIESTER_SSO_CLICK_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,source_role,categorical,35,1,supporting_backbone_chemistry_bioactivit,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,splice_switching_activity_proxy,float,35,35,0.11214 | 0.13619 | 0.38301,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lna_phosphothiotriester_splice_switching.csv,value_origin,categorical,35,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,arm,categorical,20,5,PBS_control | LNP_CRISPR_negative_sgRNA | LNP_CRISPR_mHao1_low_dose,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,assumption_id,categorical,20,1,ASM_060,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,challenge_gap_addressed,categorical,20,1,long_duration_liver_targeted_nucleic_aci,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,disease_context,categorical,20,1,primary_hyperoxaluria_type_1_PH1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,dose_mg_per_kg_proxy,float,20,3,0.0 | 0.3 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,followup_day,integer,20,4,14 | 90 | 180,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,glycolate_oxidase_expression_reduction_proxy,float,20,16,0.0 | 0.05934 | 0.00466,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,immune_response_signal_proxy,float,20,20,0.02296 | 0.03147 | 0.04495,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,judging_alignment,categorical,20,1,Feasibility_and_Rigor|Transparency_and_R,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,kidney_crystal_burden_proxy,float,20,20,0.81597 | 0.88407 | 0.839,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,liver_editing_efficiency_fraction_proxy,float,20,15,0.0 | 0.01921 | 0.00378,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,liver_toxicity_signal_proxy,float,20,20,0.02274 | 0.03804 | 0.05959,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,modality,categorical,20,1,LNP_CRISPR_Cas9_sgRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,modeling_value,categorical,20,1,supports liver-targeted nucleic-acid del,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,module_record_id,string,20,20,supplemental_PH1_PBS_control_14d | supplemental_PH1_PBS_control_90d | supplemental_PH1_PBS_control_180d,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,predicted_offtarget_indel_signal_proxy,float,20,20,0.01274 | 0.02921 | 0.00654,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,route,categorical,20,1,intravenous_LNP,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,safety_specificity_score_proxy,float,20,20,0.9781 | 0.97016 | 0.95848,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,single_administration_durability_score_proxy,float,20,5,0.0 | 0.949 | 0.94377,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,source_id,categorical,20,1,JIANG_LNP_CRISPR_HAO1_PH1_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,source_role,categorical,20,1,supporting_liver_targeted_nucleic_acid_d,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,target_gene,categorical,20,1,HAO1/Hao1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,urinary_oxalate_burden_proxy,float,20,20,1.17734 | 1.19801 | 1.18831,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
lnp_crispr_hao1_ph1_safety.csv,value_origin,categorical,20,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_hbv_hcc_state,categorical,1120,5,not_modeled | HBx_MALAT1_IGF2BP3_oncogenic_HCC_state | ASO_MALAT1_HBV_HCC_tumor_suppression,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_hbv_context_type,categorical,1120,2,not_applicable | HBV_HBx_HCC_ASO_lncRNA_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_hbx_expression_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_hbv_related_hcc_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_expression_score_proxy,float,1120,12,0.0 | 0.84966 | 0.2903,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_hbv_hcc_poor_prognosis_score_proxy,float,1120,12,0.0 | 0.67882 | 0.36763,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_m6a_score_proxy,float,1120,12,0.0 | 0.67957 | 0.34899,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_mettl3_mettl14_wtap_recruitment_score_proxy,float,1120,12,0.0 | 0.80646 | 0.3334,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_m6a_site_6021A_score_proxy,float,1120,12,0.0 | 0.67229 | 0.32344,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_m6a_site_7265A_score_proxy,float,1120,12,0.0 | 0.66001 | 0.40102,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_igf2bp3_expression_score_proxy,float,1120,12,0.0 | 0.71822 | 0.46274,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_igf2bp3_binding_score_proxy,float,1120,12,0.0 | 0.69879 | 0.48949,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_igf2bp3_kh3_domain_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_cytoplasmic_export_score_proxy,float,1120,12,0.0 | 0.57292 | 0.53929,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_rna_stability_half_life_hours_proxy,float,1120,12,0.0 | 17.48589 | 14.68476,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_aso_treatment_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_aso_tumor_suppression_score_proxy,float,1120,11,0.0 | 0.15652 | 0.92421,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_xenograft_suppression_score_proxy,float,1120,12,0.0 | 0.20369 | 0.98247,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_orthotopic_liver_tumor_suppression_score_proxy,float,1120,12,0.0 | 0.25531 | 0.93951,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_hbv_pgRNA_reduction_proxy,float,1120,10,0.0 | 0.1154 | 0.25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_hbv_DNA_reduction_proxy,float,1120,11,0.0 | 0.40731 | 0.05191,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_emtscore_vimentin_proxy,float,1120,12,0.0 | 0.67226 | 0.41068,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_e_cadherin_recovery_score_proxy,float,1120,12,0.0 | 0.55824 | 0.90905,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_hepatocarcinogenesis_context_modifier,float,1120,11,0.0 | 0.65181 | 0.59177,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_direct_oligotox_relevance_modifier,float,1120,12,0.0 | 0.11954 | 0.15288,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,malat1_hbv_hcc_context_confidence_score,float,1120,12,0.0 | 0.86844 | 0.90746,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,context_note,categorical,1120,3,Supporting MALAT1/HBV/HCC ASO context | Supporting HBV/HBx-related HCC ASO-MALAT | No MALAT1/HBV/HCC ASO context modeled fo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
malat1_hbv_hcc_aso_context.csv,value_origin,categorical,1120,4,literature_grounded_generated | inferred_from_paper | not_reported,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_cirrhosis_state,categorical,1120,4,not_modeled | high_risk_cirrhosis_post_discharge_morta | low_risk_cirrhosis_post_discharge_mortal,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_context_type,categorical,1120,3,not_modeled | clinical_cirrhosis_mortality_risk_contex | not_applicable,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_cirrhosis_related_admission_flag,integer,1120,2,0.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_uses_emr_structured_variables_flag,integer,1120,2,0.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_variable_count_proxy,integer,1120,2,0.0 | 9.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_meld_na_component_count_proxy,integer,1120,2,0.0 | 4.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_albumin_g_dl_proxy,float,1120,11,0.0 | 2.54349 | 3.39428,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_total_bilirubin_mg_dl_proxy,float,1120,11,0.0 | 5.19518 | 0.87482,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_creatinine_mg_dl_proxy,float,1120,11,0.0 | 1.75739 | 0.76745,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_inr_proxy,float,1120,11,0.0 | 1.84089 | 0.96113,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_sodium_mmol_l_proxy,float,1120,11,0.0 | 136.42915 | 138.82276,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_wbc_th_cumm_proxy,float,1120,11,0.0 | 10.54493 | 3.07463,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_total_cholesterol_mg_dl_proxy,float,1120,11,0.0 | 94.15689 | 144.8127,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_age_years_proxy,float,1120,11,0.0 | 74.73189 | 45.84616,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_length_of_stay_days_proxy,float,1120,11,0.0 | 13.30606 | 1.92592,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_predicted_90day_mortality_probability_proxy,float,1120,11,0.0 | 0.31151 | 0.10331,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_risk_quintile_proxy,categorical,1120,5,not_modeled | Q1_highest_risk | Q4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_observed_predicted_alignment_score_proxy,float,1120,11,0.0 | 0.94965 | 0.97391,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_auroc_mgh_bwh_90day_proxy,float,1120,2,0.0 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_auroc_meldna_90day_proxy,float,1120,2,0.0 | 0.7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_auroc_mgh_bwh_approx_1yr_proxy,float,1120,2,0.0 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_auroc_external_validation_proxy,float,1120,2,0.0 | 0.69,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_improvement_over_meldna_90day_pct_proxy,float,1120,2,0.0 | 11.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_improvement_over_meldna_external_pct_proxy,float,1120,2,0.0 | 16.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_clinical_severity_modifier,float,1120,11,0.0 | 0.48347 | 0.28593,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_direct_oligotox_relevance_modifier,float,1120,11,0.0 | 0.08716 | 0.09268,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,meldplus_context_confidence_score,float,1120,11,0.0 | 0.72202 | 0.83528,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,context_note,categorical,1120,3,Supporting MELD-Plus clinical liver-risk | Supporting clinical cirrhosis severity/o | No MELD-Plus/cirrhosis clinical-risk con,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
meldplus_cirrhosis_risk_context.csv,value_origin,categorical,1120,4,literature_grounded_generated | inferred_from_paper | not_reported,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
model_readiness_report.csv,include_in_baseline_model,string,31,20,yes | yes_label | validation_only,Modeling-readiness summary across required predictor and outcome fields.
model_readiness_report.csv,modeling_role,string,31,24,primary_entity_table | predictor_table | assay_context_table,Modeling-readiness summary across required predictor and outcome fields.
model_readiness_report.csv,recommended_use,string,31,26,"oligo-level features, IDs, modality, tar | PS burden, sugar chemistry, backbone, li | GC, Tm, off-target and sequence-derived ",Modeling-readiness summary across required predictor and outcome fields.
model_readiness_report.csv,table_name,string,31,31,oligos.csv | chemical_modifications.csv | biophysical_properties.csv,Modeling-readiness summary across required predictor and outcome fields.
mptp_oxmtdna_mash_pyroptosis.csv,ALT_AST_liver_injury_score_proxy,float,5,4,0.78 | 0.34 | 0.73,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,NLRP3_activation_score_proxy,float,5,5,0.84 | 0.38 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,assumption_id,categorical,5,1,ASM_084,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,cell_context,string,5,3,macrophage | THP1_derived_macrophage | liver_macrophage,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,challenge_alignment,categorical,5,1,supports mechanistic liver-injury modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,condition_or_intervention,string,5,5,MCD_diet | MCD_plus_CsA | free_fatty_acid_in_vitro,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,cytosolic_ox_mtdna_context,categorical,5,2,high | reduced,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,fibrosis_or_progression_context_score_proxy,float,5,5,0.74 | 0.3 | 0.66,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,macrophage_pyroptosis_score_proxy,float,5,5,0.82 | 0.35 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,modeling_role,string,5,5,disease_context_positive | mechanism_rescue_control | in_vitro_stress_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,module_id,categorical,5,1,mptp_oxmtdna_mash_pyroptosis,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,notes,categorical,5,1,Generated scenario row; proxy values enc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,overall_MASH_injury_score_proxy,float,5,5,0.8 | 0.32 | 0.7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,provenance_label,categorical,5,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,scenario_id,string,5,5,MCD_MASH_baseline | MCD_CsA_mPTP_inhibition | FFA_THP1_macrophage_stress,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,siRNA_or_gene_silencing_context,categorical,5,2,no | yes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,source_id,categorical,5,1,ZHANG_MPTP_OXMTDNA_MASH_ITPR3_NLRP3_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
mptp_oxmtdna_mash_pyroptosis.csv,value_origin,categorical,5,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,oligo_id,identifier,4,4,OLIGO_0000174 | OLIGO_0000346 | OLIGO_0000579,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,control_id,categorical,4,1,NON_CONTROL_GENERATED_RECORD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,source_id,categorical,4,1,SOUSA_HDO_MULTIFUNCTIONAL_HELA_2022,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,target_gene,string,4,4,ALK4 | APOB | ERBB2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,modality,string,4,3,siRNA | GalNAc-LNA-ASO | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,heteroduplex_ASO_RNA_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,folate_ligand_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,peptide_ligand_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,dual_functionalization_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,intracellular_delivery_score_proxy,float,4,4,0.75649 | 0.79247 | 0.67222,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,GFP_fluorescence_reduction_pct_proxy,integer,4,1,5.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,BCL2_knockdown_score_proxy,float,4,4,0.69677 | 0.72991 | 0.61915,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,offtarget_toxicity_design_attention_score_proxy,float,4,4,0.54746 | 0.5735 | 0.48647,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,non_liver_delivery_gap_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,challenge_gap_addressed,categorical,4,1,delivery_design_context_for_non_liver_ol,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,direct_oligotox_relevance,categorical,4,1,supporting_delivery_design_context_not_l,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,value_origin,categorical,4,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,assumption_id,categorical,4,1,ASM_050,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,hash_proxy,float,4,4,0.47856 | 0.70699 | 0.01657,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
multifunctional_hdo_delivery.csv,hash_proxy_2,float,4,4,0.72506 | 0.22451 | 0.85407,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,oligo_id,identifier,10,10,OLIGO_0000342 | OLIGO_0000389 | OLIGO_0000396,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,control_id,categorical,10,1,NON_CONTROL_GENERATED_RECORD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,source_id,categorical,10,1,MEKONNEN_MYC_ASIRNA_DCA_TNBC_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,target_gene,string,10,9,DDR_repair_enzyme_binding_context | ANGPTL8 | PAPD7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,modality,string,10,9,gapmer | GalNAc-LNA-ASO | siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,asymmetric_siRNA_flag,integer,10,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,docosanoic_acid_conjugation_flag,integer,10,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,vinylphosphonate_modification_flag,integer,10,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,reduced_passenger_seed_offtarget_score_proxy,float,10,10,0.75647 | 0.80167 | 0.81737,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,nuclease_resistance_score_proxy,float,10,10,0.77638 | 0.82276 | 0.83888,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,durable_knockdown_days_proxy,integer,10,1,5.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,MYC_knockdown_score_proxy,float,10,10,0.73656 | 0.78057 | 0.79586,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,RRM2_RAD51_PARP1_downstream_suppression_proxy,float,10,10,0.6868 | 0.72783 | 0.74209,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,visible_toxicity_absence_score_proxy,float,10,10,0.8361 | 0.88605 | 0.90341,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,extrahepatic_delivery_context_flag,integer,10,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,challenge_gap_addressed,categorical,10,1,siRNA_design_offtarget_reduction_and_dur,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,direct_oligotox_relevance,categorical,10,1,supporting_modification_delivery_safety_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,value_origin,categorical,10,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,assumption_id,categorical,10,1,ASM_049,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,hash_proxy,float,10,10,0.47843 | 0.76839 | 0.87602,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
myc_asirna_dca_design_safety.csv,hash_proxy_2,float,10,10,0.25753 | 0.776 | 0.60876,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,delivery_id,string,1120,1120,DELIV_CTRL_OLIGO_NEG_VEHICLE_MOCK | DELIV_CTRL_OLIGO_NEG_LOW_RISK | DELIV_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,delivery_carrier_type,categorical,1120,20,cholesterol_conjugate | no_nanocarrier | PLGA_nanoparticle,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,delivery_carrier_class,categorical,1120,7,none | polymeric | direct_ligand_conjugate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,nanoparticle_size_nm,float,1120,407,0.0 | 122.66673 | 85.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,zeta_potential_mV,float,1120,412,0.0 | -0.33049 | -8.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,pegylated,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,targeting_ligand,categorical,1120,7,none | GalNAc | galactose,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,targeting_receptor,categorical,1120,5,none | ASGPR | mannose_receptor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,encapsulation_efficiency,float,1120,394,0.0 | 0.79382 | 0.90757,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,release_half_life_hours,float,1120,411,0.0 | 81.86958 | 14.03248,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,hepatic_targeting_score,float,1120,871,0.41749 | 0.28 | 0.96697,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,kupffer_clearance_risk,float,1120,883,0.03097 | 0.08 | 0.16635,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,delivery_immunogenicity_score,float,1120,878,0.08285 | 0.08 | 0.17857,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,delivery_oxidative_stress_score,float,1120,803,0.06177 | 0.03 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,delivery_toxicity_modifier,float,1120,895,-0.02771 | 0.0515 | -0.16845,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nanoparticle_delivery.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nat_model_selection_evidence.csv,assumption_id,categorical,7,1,ASM_128,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nat_model_selection_evidence.csv,key_model_selection_consideration,string,7,7,gene_isoform_expression_check | genome_context_and_variant_specificity | unassisted_cellular_uptake,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nat_model_selection_evidence.csv,model_type,string,7,7,immortalized_or_relevant_cell_line | patient_cells | in_vitro_delivery_condition,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nat_model_selection_evidence.csv,model_validity_score_proxy,float,7,7,0.74 | 0.82 | 0.68,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nat_model_selection_evidence.csv,module_id,categorical,7,1,preclinical_model_selection_for_NATs,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nat_model_selection_evidence.csv,notes,string,7,7,useful_for_screening_but_target_isoform_ | better_variant_specificity_and_individua | may_better_reflect_in_vivo_activity_than,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nat_model_selection_evidence.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nat_model_selection_evidence.csv,scenario_id,string,7,7,endogenous_target_cell_line_screen | patient_derived_cell_model | free_uptake_gymnosis_assay,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nat_model_selection_evidence.csv,source_id,categorical,7,1,OLIVER_HILL_MODEL_SELECTION_NAT_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nat_model_selection_evidence.csv,toxicity_interpretation_complexity_score_proxy,float,7,6,0.58 | 0.5 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nat_model_selection_evidence.csv,translation_relevance_score_proxy,float,7,6,0.6 | 0.72 | 0.36,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nat_model_selection_evidence.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,ALT_AST_liver_injury_score_proxy,float,6,6,0.7 | 0.78 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,NG2_CSPG4_expression_score_proxy,float,6,5,0.78 | 0.85 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,assumption_id,categorical,6,1,ASM_085,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,challenge_alignment,categorical,6,1,supports direct liver fibrosis and injur,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,collagen_fibrosis_score_proxy,float,6,6,0.74 | 0.82 | 0.76,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,intervention_or_observation,categorical,6,2,observational | Cspg4_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,model_system,string,6,5,human_fibrotic_liver | MCDHF_mouse_liver | CCl4_mouse_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,modeling_role,string,6,6,human_context | disease_model_positive | orthogonal_fibrosis_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,module_id,categorical,6,1,ng2_cspg4_sirna_liver_fibrosis,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,myofibroblast_activation_score_proxy,float,6,6,0.8 | 0.88 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,notes,categorical,6,1,Generated scenario row; proxy values enc,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,scenario_id,string,6,6,human_fibrotic_liver_CSPG4_high | MCDHF_fibrosis_NG2_high | CCl4_fibrosis_NG2_high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,siRNA_context,categorical,6,2,no | yes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,source_id,categorical,6,1,YANG_NG2_CSPG4_SIRNA_LIVER_FIBROSIS_2023,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,steatosis_inflammation_score_proxy,float,6,6,0.66 | 0.76 | 0.7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ng2_cspg4_sirna_liver_fibrosis.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,assumption_id,categorical,5,1,ASM_099,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,challenge_alignment,categorical,5,1,"supporting module for delivery, immune-c",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,delivery_or_targeting_score_proxy,float,5,5,0.45 | 0.7 | 0.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,immune_or_cell_state_score_proxy,float,5,5,0.82 | 0.2 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,modality_or_platform,string,5,4,systemic_ASO | tissue_selective_siRNA | genetic_comparator,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,model_system,string,5,5,APOE_Leiden_CETP_mouse | liver_adipose | lesional_macrophage_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,modeling_role,string,5,5,systemic_ASO_disease_modification | limited_effect_compartment_contrast | macrophage_compartment_mechanism,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,module_id,categorical,5,1,NNMT_ASO_macrophage_immunometabolism,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,notes,categorical,5,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,primary_effect_score_proxy,float,5,5,0.9 | 0.72 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,provenance_label,categorical,5,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,scenario_id,string,5,5,global_NNMT_ASO_hyperlipidemic_mice | liver_adipose_selective_NNMT_siRNA | Nnmt_KO_bone_marrow_transplant,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,source_id,categorical,5,1,SINHA_NNMT_ASO_MACROPHAGE_ATHEROSCLEROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,toxicity_or_safety_signal_proxy,float,5,4,0.22 | 0.18 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
nnmt_aso_macrophage_atherosclerosis.csv,value_origin,categorical,5,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,cell_model,string,1120,99,primary_human_hepatocytes | clinical_liver_readout_proxy | human_liver_spheroid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_lsec_state,categorical,1120,6,not_modeled | lipotoxic_hepatocyte_sEV_OGT_high | OGT_knockdown_sEV_reduced_capillarizatio,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_context_type,categorical,1120,2,not_applicable | supporting_MASLD_liver_microenvironment_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_lth_sev_dose_ug_ml_proxy,integer,1120,3,0.0 | 400.0 | 200.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_diameter_nm_proxy,float,1120,19,0.0 | 108.34859 | 92.75209,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_liver_enrichment_score_proxy,float,1120,19,0.0 | 0.69218 | 0.88031,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_lsec_endocytosis_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_ogt_cargo_score_proxy,float,1120,19,0.0 | 0.76398 | 0.13827,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_oga_change_score_proxy,float,1120,19,0.0 | 0.11032 | 0.01978,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_total_OGlcNAcylation_score_proxy,float,1120,17,0.0 | 0.82633 | 0.18459,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_HNF1A_ser471_OGlcNAcylation_score_proxy,float,1120,17,0.0 | 0.895 | 0.30292,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_HNF1A_nuclear_translocation_score_proxy,float,1120,19,0.0 | 0.73057 | 0.4005,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_Ang2_transcription_activation_score_proxy,float,1120,18,0.0 | 0.80701 | 0.19478,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_Ang2_serum_proxy_ng_ml_scaled,float,1120,19,0.0 | 498.00832 | 271.45422,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_LSEC_capillarization_score_proxy,float,1120,17,0.0 | 0.66364 | 0.13266,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_LSEC_defenestration_score_proxy,float,1120,19,0.0 | 0.61904 | 0.13405,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_CD31_vascularization_score_proxy,float,1120,19,0.0 | 0.69137 | 0.28806,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_alpha_SMA_activation_score_proxy,float,1120,17,0.0 | 0.70076 | 0.28217,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_collagen_deposition_score_proxy,float,1120,17,0.0 | 0.75936 | 0.26649,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_ALT_AST_correlation_context_score_proxy,float,1120,18,0.0 | 0.72069 | 0.39102,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_TG_correlation_context_score_proxy,float,1120,19,0.0 | 0.6132 | 0.3317,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_inflammation_IL1B_IL6_TNFA_score_proxy,float,1120,17,0.0 | 0.80429 | 0.25831,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_serum_OGT_AUC_proxy,float,1120,2,0.0 | 0.6832,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_serum_sEV_OGT_AUC_proxy,float,1120,2,0.0 | 0.7278,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_OGT_knockdown_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_BAGN_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_BAGN_dose_mg_proxy,float,1120,3,0.0 | 1.0 | 0.5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_BAGN_rescue_score_proxy,float,1120,3,0.0 | 0.35868 | 0.23267,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_masld_progression_modifier,float,1120,19,0.0 | 0.75195 | 0.26113,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_direct_oligotox_relevance_modifier,float,1120,19,0.0 | 0.09023 | 0.03134,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,ogt_sev_context_confidence_score,float,1120,19,0.0 | 0.966 | 0.83841,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,context_note,categorical,1120,3,No OGT/sEV/LSEC/MASLD context modeled fo | Supporting MASLD/LSEC extracellular-vesi | Supporting OGT/sEV/LSEC/MASLD context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ogt_sev_lsec_masld_context.csv,value_origin,categorical,1120,4,not_reported | inferred_from_paper | literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oligo_modification_positions.csv,oligo_id,string,24147,1089,CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE | CTRL_OLIGO_NEG_SPHEROID_TOLERATED,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
oligo_modification_positions.csv,strand,categorical,24147,2,antisense | single,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
oligo_modification_positions.csv,position,integer,24147,30,1 | 2 | 3,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
oligo_modification_positions.csv,base,categorical,24147,5,A | U | C,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
oligo_modification_positions.csv,sugar_modification,string,24147,40,2-prime-O-methyl | 2-prime-fluoro | 2-prime-MOE,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
oligo_modification_positions.csv,backbone_3prime_linkage,categorical,24147,2,phosphorothioate | phosphodiester,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
oligo_modification_positions.csv,region,categorical,24147,9,5_prime_terminal | seed_region | central,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
oligo_modification_positions.csv,terminal_conjugate,categorical,24147,2,none | GalNAc_3prime,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
oligo_modification_positions.csv,modification_provenance,categorical,24147,1,literature_grounded_generated,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
oligo_modification_positions.csv,source_id,string,24147,81,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Position-level chemical modifications for each oligo: per-position base, sugar modification, backbone linkage, region, conjugation, and provenance."
oligos.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oligos.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oligos.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oligos.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oligos.csv,sequence_5to3,string,1105,1066,AUAUCUAUAUCUAUAUCUAUA | GCUAUGAACUUGACUCUAUGA | UUCGAUAGGCCACGAGAUUAU,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oligos.csv,sequence_length,integer,1120,19,0 | 21 | 19,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oligos.csv,is_administered_oligo,boolean,1120,2,True | False,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oligos.csv,sequence_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oligos.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oligos.csv,control_type,string,1120,114,negative_control_vehicle_mock | negative_control_low_risk_oligo | clinical_low_hepatotoxicity_reference,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oligos.csv,record_origin,categorical,1120,1,dbbun_generated,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oligos.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oligos.csv,confidence_level,float,1120,936,0.88 | 0.9 | 0.82,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oligos.csv,license_for_generated_output,categorical,1120,1,CC BY 4.0,"Oligonucleotide-level metadata: identifiers, modality, sequence, length, target gene, control assignment."
oral_mir29a_liver_fibrosis_na.csv,alt_fold_baseline_proxy,float,120,120,3.81933 | 3.97865 | 3.45671,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,col1a1_suppression_fraction_proxy,float,120,104,0.0 | 0.01623 | 0.01699,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,collagen_deposition_score_proxy,float,120,120,0.96914 | 0.82144 | 0.94073,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,delivery_system,categorical,120,1,none_no_DDS_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,disease_context,categorical,120,2,CCl4_chronic_liver_fibrosis | in_vitro_target_suppression_screen,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,fibrosis_improvement_score_proxy,float,120,111,0.0 | 0.12487 | 0.15643,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,gi_tract_detection_score_proxy,float,120,116,0.02045 | 0.03524 | 0.01791,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,judging_alignment,categorical,120,1,Potential_Impact|Feasibility_and_Rigor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,liver_detection_score_proxy,float,120,109,0.04451 | 0.00787 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,modeling_value,categorical,120,1,supporting_liver_delivery_fibrosis_modif,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,modified_na_tolerability_score_proxy,float,120,120,0.77212 | 0.75704 | 0.73143,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,module_record_id,string,120,120,MIR29A_FIB_0001 | MIR29A_FIB_0002 | MIR29A_FIB_0003,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,nuclease_resistant_design,categorical,120,1,RNA_DNA_hybrid_LNA_PS_2primeF_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,pdgfc_suppression_fraction_proxy,float,120,109,0.08084 | 0.0 | 0.04634,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,route,categorical,120,2,oral | cell_transfection_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,source_id,categorical,120,1,UMEZU_ORAL_MIR29A_LIVER_FIBROSIS_NA_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,treatment_arm,categorical,120,5,CCl4_only | oral_seed_miR29a_like_modified_NA | oral_COL1A1_targeting_RNA_DNA_hybrid,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,value_origin,categorical,120,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
oral_mir29a_liver_fibrosis_na.csv,week_context,integer,120,4,1 | 2 | 5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,oligo_id,identifier,35,35,OLIGO_0000075 | OLIGO_0000093 | OLIGO_0000183,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,control_id,categorical,35,6,NON_CONTROL_GENERATED_RECORD | CTRL_NEG_PCDHA11_AMNA_2255_LOW_REVERSIBL | CTRL_NEG_PCDHA11_AMNA_3319_LOW_OFFTARGET,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,source_id,categorical,35,1,KANDA_PCDHA11_AMNA_ASO_2024,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,target_gene,categorical,35,1,PCDHA11,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,modality,categorical,35,1,AmNA-modified_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,cell_model,unknown,0,0,,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,pcdha11_amna_state,categorical,35,6,lower_liver_signal_2255_like_reversible_ | lower_offtarget_3319_like_reversible_con | high_sequence_dependent_reversible_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,pcdha11_candidate_proxy,categorical,35,6,hPCDHA11_2255_like | hPCDHA11_3319_like | hPCDHA11_3969_like,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,AmNA_modified_flanking_nucleotide_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,all_phosphate_groups_phosphorothioated_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,intraperitoneal_weekly_mouse_toxicology_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,in_vitro_transfection_context_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,in_vitro_transfection_nM_proxy,integer,35,3,400.0 | 25.0 | 100.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,mouse_intraperitoneal_dose_mg_proxy,float,35,3,0.2 | 0.6 | 2.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,mouse_dose_tier,categorical,35,3,0.2_mg_low | 0.6_mg_mid | 2.0_mg_high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,weekly_administration_weeks_proxy,integer,35,1,4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,post_cessation_recovery_weeks_proxy,integer,35,1,3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,PCDHA11_knockdown_efficacy_score_proxy,float,35,34,0.8708 | 0.4714 | 0.8584,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,tumor_growth_inhibition_score_proxy,float,35,35,0.6792 | 0.4123 | 0.6593,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,apoptosis_caspase_activation_score_proxy,float,35,34,0.5989 | 0.3792 | 0.5921,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,migration_invasion_spheroid_stemness_inhibition_score_proxy,float,35,34,0.6851 | 0.4534 | 0.6779,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,AST_peak_fold_proxy,float,35,35,4.3409 | 4.7041 | 4.9328,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,ALT_peak_fold_proxy,float,35,35,3.9666 | 4.2898 | 4.4916,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,ALP_peak_fold_proxy,float,35,22,2.0834 | 2.3169 | 2.4294,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,total_bilirubin_fold_proxy,integer,35,1,1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,bilirubin_elevation_flag,integer,35,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,renal_dysfunction_flag,integer,35,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,creatinine_fold_proxy,float,35,35,1.0266 | 1.0104 | 1.0219,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,urea_nitrogen_fold_proxy,float,35,35,1.0266 | 1.0104 | 1.0219,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,amylase_fold_proxy,float,35,34,1.023 | 1.0108 | 1.016,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,body_weight_ratio_end_to_baseline_proxy,float,35,28,1.0028 | 0.9999 | 1.0017,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,gross_skin_injection_site_signal_flag,integer,35,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,organ_histology_major_change_flag,integer,35,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,recovery_after_treatment_cessation_score_proxy,float,35,17,0.88 | 0.84 | 0.62,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,reversibility_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,sequence_dependent_liver_injury_score_proxy,float,35,18,0.32 | 0.38 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,dose_dependent_liver_injury_score_proxy,float,35,3,0.1 | 0.3 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,offtarget_mismatch_burden_proxy,integer,35,6,10 | 16 | 47,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,microarray_offtarget_perturbation_score_proxy,float,35,32,0.4563 | 0.5631 | 0.57,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,GGGenome_like_mismatch_screening_context_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,microarray_validation_context_flag,integer,35,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,PCDHA11_knockout_specificity_context_flag,integer,35,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,normal_Pcdha11_deficient_mouse_context_flag,integer,35,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,overall_pcdha11_amna_hepatotoxicity_score_proxy,float,35,35,3.0326 | 3.3525 | 3.4787,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,direct_oligotox_hepatotoxicity_relevance,categorical,35,1,direct_preclinical_oligo_hepatotoxicity_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,phase2_alignment,categorical,35,1,direct_liver_readouts_controls_dose_sequ,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,value_origin,categorical,35,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcdha11_amna_aso_hepatotoxicity.csv,assumption_id,categorical,35,1,ASM_042,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,assumption_id,categorical,6,1,ASM_114,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,delivery_or_targeting_score_proxy,float,6,6,0.7 | 0.66 | 0.44,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,mechanism_or_specificity_score_proxy,float,6,5,0.86 | 0.9 | 0.92,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,modality_or_platform,string,6,6,PCSK9-siRNA_plus_STING_agonist | siRNA_immunomodulation | cellular_trafficking_mechanism,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,model_system,string,6,6,BMDC_and_monocyte_reporter_models | STING_KO_validation_context | COPII_STING_anterograde_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,modeling_role,string,6,6,siRNA_modulation_of_innate_immune_pathwa | mechanistic_specificity_validation | subcellular_mechanism_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,module_id,categorical,6,1,PCSK9_siRNA_STING_hepatic_immune_toxicit,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,primary_effect_score_proxy,float,6,6,0.84 | 0.82 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,scenario_id,string,6,6,PCSK9_siRNA_STING_signal_amplification | STING_dependent_IFN_response | SURF4_STING_PCSK9_trafficking,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,source_id,categorical,6,1,SUN_PCSK9_SIRNA_STING_CANCER_IMMUNOTHERA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,toxicity_or_safety_signal_proxy,float,6,5,0.3 | 0.32 | 0.24,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pcsk9_sirna_sting_cancer_immunotherapy.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,assumption_id,categorical,6,1,ASM_117,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,delivery_or_targeting_score_proxy,float,6,4,0.86 | 0.88 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,mechanism_or_specificity_score_proxy,float,6,6,0.84 | 0.86 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,modality_or_platform,string,6,3,aptamer-siRNA_chimera | siRNA_gene_silencing | aptamer-siRNA_immunotherapy,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,model_system,string,6,6,PDL1_CD47_dual_targeting_design | Hepa1_6_HCC_tumor_infiltrating_Tregs | tumor_associated_Treg_cells,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,modeling_role,string,6,6,selective_RNA_payload_design_context | cell_selective_delivery_context | RNAi_target_knockdown_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,module_id,categorical,6,1,PDL1_aptamer_CD47_siRNA_Treg_HCC_module,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,primary_effect_score_proxy,float,6,6,0.76 | 0.82 | 0.84,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,scenario_id,string,6,6,PDL1_aptamer_CD47_siRNA_design | intratumoral_Treg_selective_binding | CD47_knockdown_Treg_cells,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,source_id,categorical,6,1,ZENG_PDL1_APTAMER_CD47_SIRNA_TREG_HCC_20,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,toxicity_or_safety_signal_proxy,float,6,5,0.24 | 0.2 | 0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pdl1_aptamer_cd47_sirna_treg_hcc.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,personalized_aso_id,string,1120,1120,PASO_CTRL_OLIGO_NEG_VEHICLE_MOCK | PASO_CTRL_OLIGO_NEG_LOW_RISK | PASO_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,personalized_aso_state,categorical,1120,6,baseline_not_personalized | n_of_1_clinical_monitoring | rat_intrathecal_toxicology,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,customized_to_patient_variant,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,splice_modulating_strategy,categorical,1120,3,not_personalized_context | cryptic_splice_acceptor_blocking | splice_enhancer_masking,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,cryptic_splice_site_targeted,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,aso_length_nt_proxy,integer,1120,7,0 | 22 | 23,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,aso_backbone_chemistry,categorical,1120,2,not_applicable | phosphorothioate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,aso_sugar_chemistry,categorical,1120,4,not_applicable | 2prime_MOE | 2prime_OMe,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,sequence_specific_offtarget_screen_pass,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,fibroblast_splice_rescue_fold_proxy,float,1120,25,0.0 | 3.0 | 2.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,normal_splicing_fraction_proxy,float,1120,25,0.0 | 0.34 | 0.28,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,functional_cell_rescue_score_proxy,float,1120,25,0.0 | 0.7 | 0.58,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,intrathecal_route_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,cns_targeting_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,rat_toxicology_dose_multiple_proxy,float,1120,4,0.0 | 2.5 | 10.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,transient_neurotoxicity_signal_proxy,float,1120,7,0.0 | 0.35 | 0.60793,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,human_dose_mg_proxy,integer,1120,6,0.0 | 42.0 | 35.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,dose_escalation_schedule_proxy,categorical,1120,4,not_applicable | escalating_loading_then_quarterly_mainte | preclinical_toxicology,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,csf_trough_ng_per_ml_proxy,float,1120,11,0.0 | 22.0 | 21.64432,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,systemic_exposure_context_label,categorical,1120,3,not_applicable | limited_systemic_exposure | not_clinical_dosing,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,personalized_workflow_confidence_score,float,1120,26,0.0 | 0.72 | 0.712,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,context_note,categorical,1120,2,patient-customized ASO design/safety wor | patient-customized ASO workflow context;,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
personalized_aso_workflow.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,oligo_id,identifier,17,17,OLIGO_0000023 | OLIGO_0000307 | OLIGO_0000458,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,source_id,categorical,17,1,WANG_PMEVL_SEV_SMALL_RNA_PCSK9_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,control_id,categorical,17,4,NON_CONTROL_GENERATED_RECORD | CTRL_NEG_PMEVL_SEV_SIPCSK9_LOW_SYSTEMIC_ | CTRL_CONTEXT_PMEVL_N_MYRISTOYLATION_RNA_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,target_gene,categorical,17,7,DGAT2 | PCSK9 | PNPLA3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,oligo_modality,categorical,17,1,engineered_sEV_siRNA_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,pmevl_state,categorical,17,3,PMEVL_sEV_siPcsk9_hepatic_delivery_safe | PMEVL_N_myristoylation_small_RNA_loading | not_primary_PMEVL_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,pmevl_context_flag,integer,17,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,engineered_sEV_delivery_flag,integer,17,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,N_myristoylation_peptide_loading_flag,integer,17,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,myr_peptide_class_proxy,categorical,17,1,CHMP6_or_optimized_Myr_peptide,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,RNA_cargo_class,categorical,17,3,siPcsk9 | multi_RNA_loading_context | not_applicable,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,PMEVL_target_gene_context,categorical,17,5,PCSK9 | APOC3 | DGAT2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,pri_miR30a_siRNA_scaffold_flag,integer,17,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,multi_siRNA_coloading_context_flag,integer,17,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,protein_RNA_coloading_context_flag,integer,17,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,sEV_size_nm_proxy,integer,17,1,134.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,sEV_particles_per_cell_proxy,integer,17,1,260.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,siRNA_loading_fold_enrichment_proxy,integer,17,4,410.0 | 60.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,miRNA_loading_fold_enrichment_proxy,integer,17,4,15.0 | 60.0 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,mRNA_loading_fold_enrichment_proxy,integer,17,1,278.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,ANXA2_RNA_sorting_context_score,float,17,1,0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,ALIX_TSG101_ESCRT_sorting_context_score,float,17,1,0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,AGO2_RISC_bridge_context_score,float,17,1,0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,ERK1_2_activation_score_proxy,float,17,1,0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,AMPK_autophagy_inhibition_score_proxy,float,17,1,0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,hepatic_biodistribution_score_proxy,float,17,3,0.86 | 0.35 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,hepatic_Pcsk9_knockdown_fraction_proxy,float,17,3,0.55 | 0.12 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,LDLR_expression_fold_proxy,float,17,3,1.75 | 1.05 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,serum_LDL_C_change_fraction_proxy,float,17,3,-0.28 | -0.04 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,serum_total_cholesterol_change_fraction_proxy,float,17,3,-0.224 | -0.032 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,serum_triglyceride_change_fraction_proxy,integer,17,1,0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,ALT_fold_normalized_proxy,float,17,2,1.02 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,AST_fold_normalized_proxy,float,17,2,1.01 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,major_organ_histology_abnormality_flag,integer,17,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,systemic_toxicity_context_label,categorical,17,3,low_systemic_toxicity_with_hepatic_RNAi_ | RNA_loading_context_no_direct_injury_sig | not_assessed_for_this_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,PMEVL_context_confidence_score,float,17,1,0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,assumption_id,categorical,17,1,ASM_031,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pmevl_sev_rna_loading_pcsk9_context.csv,record_origin,categorical,17,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,assumption_id,categorical,6,1,ASM_126,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,genotype_specificity_score_proxy,float,6,5,0.8 | 0.84 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,model_system,string,6,6,human_precision_genetics | human_primary_hepatocyte_3D_spheroid | human_transgenic_mouse,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,module_id,categorical,6,1,PNPLA3_AZD2693_precision_MASH_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,notes,string,6,6,MASH_fibrosis_cirrhosis_HCC_liver_mortal | preclinical_mRNA_protein_knockdown_conte | in_vivo_preclinical_target_engagement_co,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,pk_pd_interpretability_score_proxy,float,6,5,0.2 | 0.76 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,precision_medicine_context,categorical,6,1,PNPLA3_148M_homozygous_MASH,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,safety_signal_score_proxy,float,6,6,0.58 | 0.34 | 0.32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,scenario_id,string,6,6,PNPLA3_148M_homozygous_risk_context | AZD2693_3D_hepatocyte_spheroid_target_en | AZD2693_human_PNPLA3_transgenic_mouse,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,source_id,categorical,6,1,ARMISEN_AZD2693_PNPLA3_ASO_MASH_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,target_engagement_or_response_score_proxy,float,6,6,0.92 | 0.86 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,target_or_endpoint,string,6,6,PNPLA3_p.I148M | PNPLA3_mRNA_protein | PNPLA3_mRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_azd2693_precision_mash.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_context_id,string,1120,1120,PNPLA3_CTRL_OLIGO_NEG_VEHICLE_MOCK | PNPLA3_CTRL_OLIGO_NEG_LOW_RISK | PNPLA3_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_context_state,categorical,1120,5,baseline_non_PNPLA3 | PNPLA3_I148M_homozygous_lipid_stress | PNPLA3_homozygous_silencing_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_genotype,categorical,1120,4,not_modeled | GG_I148M_homozygous | CG_heterozygous,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_i148m_allele_count,integer,1120,3,0 | 2 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_homozygous_I148M,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_environmental_context,categorical,1120,6,not_PNPLA3_context | obesity_high_sugar_diet | overweight_insulin_resistance,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_expression_proxy,float,1120,43,0.0 | 0.72063 | 0.66325,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_lipid_droplet_accumulation_proxy,float,1120,37,0.0 | 1.0 | 0.64742,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_triglyceride_hydrolase_loss_proxy,float,1120,43,0.0 | 0.88758 | 0.97549,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_pnpla2_inhibition_proxy,float,1120,39,0.0 | 0.95 | 0.75077,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_liver_fat_liability_modifier,float,1120,36,0.0 | 1.5025 | 0.99307,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_precision_therapy_modality,categorical,1120,3,none | PNPLA3_siRNA_precision_silencing | PNPLA3_ASO_precision_silencing,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_target_knockdown_pct_proxy,float,1120,14,0.0 | 78.0 | 62.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_hepatic_fat_reduction_pct_proxy,float,1120,14,0.0 | 27.15312 | 11.78057,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_inflammation_reduction_proxy,float,1120,14,0.0 | 0.2765 | 0.07657,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_fibrosis_risk_modifier,float,1120,35,0.0 | 0.7212 | 0.31049,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_precision_rescue_modifier,float,1120,14,0.0 | 0.8309 | 0.33663,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,pnpla3_therapy_response_label,categorical,1120,5,baseline_non_PNPLA3_context | high_risk_no_precision_therapy | homozygous_precision_therapy_responder,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,context_note,categorical,1120,2,PNPLA3 precision-genetics and therapy-re | PNPLA3 precision-genetics context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pnpla3_precision_context.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,RNA_delivery_efficacy_score_proxy,float,6,6,0.32 | 0.9 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,biocompatibility_score_proxy,float,6,4,0.88 | 0.91 | 0.9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,challenge_alignment,categorical,6,1,"supports delivery realism, toxicity-safe",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,delivery_platform,string,6,5,MC3_standard_LNP | MC3_NS102_pLNP | ALC0315_NS102_pLNP,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,endosomal_escape_score_proxy,float,6,6,0.36 | 0.89 | 0.83,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,factor_VII_siRNA_activity_context,categorical,6,2,not_primary | included,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,liver_toxicity_liability_score_proxy,float,6,5,0.18 | 0.16 | 0.15,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,mRNA_expression_context,categorical,6,2,included | not_primary,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,module_id,categorical,6,1,polyamine_pLNP_RNA_delivery_safety_conte,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,notes,categorical,6,1,Generated delivery-platform row; no sour,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,pH_buffering_score_proxy,float,6,6,0.3 | 0.82 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,payload_type,string,6,4,mRNA | siRNA_FVII | mRNA_or_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,polyamine_component,categorical,6,2,none_or_standard | NS102_low_MW_tertiary_amine,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,primary_delivery_context,string,6,3,liver | systemic_or_intramuscular | mouse_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,scenario_id,string,6,6,standard_MC3_LNP_mRNA | NS102_4p5mol_pLNP_mRNA_liver | NS102_pLNP_siFVII_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,scenario_role,string,6,5,standard_lnp_reference | enhanced_liver_mRNA_expression | enhanced_siRNA_activity_lower_ED50,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,source_id,categorical,6,1,KANNAN_POLYAMINE_PLNP_RNA_DELIVERY_SAFET,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
polyamine_plnp_rna_delivery_safety.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,oligo_id,identifier,26,26,OLIGO_0000013 | OLIGO_0000048 | OLIGO_0000063,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,source_id,categorical,26,1,ANDERSSON_PRECLINICAL_OLIGO_SAFETY_2022,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,control_id,categorical,26,6,NON_CONTROL_GENERATED_RECORD | CTRL_CONTEXT_PRECLINICAL_OLIGO_SAFETY_FR | CTRL_POS_SEQUENCE_MOTIF_GAPMER_LIVER_RIS,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,target_gene,string,26,21,SULT1B1 | PCSK9 | STK25,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,oligo_modality,string,26,19,GalNAc-siRNA | high_affinity_gapmer_RNaseH1_toxicity_me | siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,sequence_length,integer,26,10,22 | 26 | 23,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,PS_fraction,float,26,24,0.2136853997268372 | 0.115637955917671 | 0.1532100225465447,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,sugar_chemistry,categorical,26,11,cEt | LNA | unmodified,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,GalNAc_flag,integer,26,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,off_target_burden_proxy,float,26,22,2.641432527839023 | 2.477738541255538 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,dose_proxy,float,26,24,6.293063088887665 | 3.6025086189026005 | 7.871927332709254,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,preclinical_safety_context_flag,integer,26,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,preclinical_safety_state,categorical,26,6,source_grounded_preclinical_safety_conte | integrated_preclinical_safety_framework | sequence_dependent_gapmer_liver_risk,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,OND_class_context,categorical,26,3,siRNA | ASO_gapmer | therapeutic_oligonucleotide_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,mechanism_class,categorical,26,3,RISC_RNAi | RNase_H_gapmer | mixed_or_general_OND,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,sequence_hybridization_dependency_class,categorical,26,7,sequence_dependent_hybridization_indepen | sequence_and_hybridization_dependent | delivery_or_Cmax_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,risk_domain_label,categorical,26,6,liver_kidney_inflammatory_monitoring | integrated_OND_safety_assessment | liver_sequence_motif_toxicity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,transcriptome_wide_in_silico_screen_required_flag,integer,26,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,in_vitro_offtarget_confirmation_required_flag,integer,26,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,on_target_exaggerated_pharmacology_review_flag,integer,26,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,cross_species_activity_limitation_flag,integer,26,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,surrogate_oligo_consideration_flag,integer,26,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,long_tissue_half_life_effect_duration_context_flag,integer,26,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,productive_uptake_distribution_label,categorical,26,3,hepatocyte_enriched | liver_kidney_spleen_exposure | delivery_platform_dependent,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,delivery_approach_context,categorical,26,3,GalNAc_ASGR_ASGPR_hepatocyte_targeting | unconjugated_or_not_reported | LNP_formulation_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,GalNAc_productive_uptake_multiplier_proxy,float,26,18,25.0 | 2.25 | 2.07,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,LNP_premedication_inflammation_context_flag,integer,26,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,plasma_Cmax_complement_or_coagulation_monitoring_flag,integer,26,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,complement_activation_risk_score_proxy,float,26,26,0.108 | 0.341 | 0.097,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,coagulation_time_risk_score_proxy,float,26,25,0.089 | 0.279 | 0.08,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,sequence_motif_hepatotoxicity_risk_score_proxy,float,26,26,0.562 | 0.551 | 0.206,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,kidney_high_exposure_monitoring_flag,integer,26,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,kidney_toxicity_risk_score_proxy,float,26,25,0.148 | 0.361 | 0.137,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,proinflammatory_risk_score_proxy,float,26,24,0.122 | 0.111 | 0.106,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,platelet_thrombocytopenia_monitoring_flag,integer,26,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,recommended_preclinical_species_context,categorical,26,1,rodent_plus_nonhuman_primate_or_surrogat,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,general_toxicology_duration_context,categorical,26,1,early_1_to_3_month_then_chronic_rodent_n,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,preclinical_safety_confidence_score,float,26,1,0.91,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,assumption_id,categorical,26,1,ASM_032,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
preclinical_oligo_safety_assessment.csv,record_origin,categorical,26,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
provenance.csv,provenance_id,string,144,144,PROV_MEMO_OLIGOTOX_PHASE2_ALIGNMENT | PROV_PNPLA3_ROMEO_VALENTI_2025 | PROV_RAPIROSIRAN_SANYAL_2025,Provenance category definitions used across the dataset.
provenance.csv,source_id,string,144,144,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | PNPLA3_ROMEO_VALENTI_2025 | RAPIROSIRAN_SANYAL_2025,Provenance category definitions used across the dataset.
provenance.csv,source_title,string,144,142,DBbun OligoTox Phase 2 Alignment Memo | Fifteen Years of PNPLA3: Transforming He | Phase I randomized double-blind study of,Provenance category definitions used across the dataset.
provenance.csv,source_type,string,144,131,alignment_memo | review_open_access | phase1_randomized_double_blind_clinical_,Provenance category definitions used across the dataset.
provenance.csv,doi_or_url,string,144,142,internal_db_bun_alignment_memo | 10.1111/liv.70240 | 10.1016/j.jhep.2025.05.031,Provenance category definitions used across the dataset.
provenance.csv,source_license_or_access,string,144,79,DBbun-authored working memo | Creative Commons Attribution | CC BY 4.0,Provenance category definitions used across the dataset.
provenance.csv,source_role,string,144,142,governing_schema_and_rules | PNPLA3_precision_genetics_siRNA_ASO_ther | HSD17B13_GalNAc_siRNA_clinical_PK_PD_liv,Provenance category definitions used across the dataset.
provenance.csv,records_generated_from_source,integer,144,29,14 | 16 | 56,Provenance category definitions used across the dataset.
provenance.csv,source_pdf_redistributed,categorical,144,1,no,Provenance category definitions used across the dataset.
provenance.csv,source_figures_or_tables_redistributed,categorical,144,1,no,Provenance category definitions used across the dataset.
provenance.csv,generation_method,categorical,144,1,single_file_configurable_synthetic_harmo,Provenance category definitions used across the dataset.
provenance.csv,record_origin_default,categorical,144,1,dbbun_generated,Provenance category definitions used across the dataset.
provenance.csv,output_license,categorical,144,1,CC BY 4.0,Provenance category definitions used across the dataset.
ps_aso_dna_damage_response.csv,oligo_id,identifier,27,27,OLIGO_0000011 | OLIGO_0000064 | OLIGO_0000079,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,control_id,categorical,27,4,NON_CONTROL_GENERATED_RECORD | CTRL_POS_PS_ASO_DDR_HIGH_CONDENSATE | CTRL_NEG_PO_ASO_LOW_DDR_NO_PS_BODY,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,source_id,categorical,27,1,HJELMGREN_PS_ASO_DDR_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,target_gene,string,27,20,PCDHA11 | PCSK9 | PAPD5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,modality,categorical,27,12,PS-ASO_DDR_toxicity_probe | AmNA-modified_ASO | GalNAc-LNP-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,cell_model_context,categorical,27,1,U2OS_HeLa_RPE1_MelJuSo_generated_DDR_scr,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,PS_backbone_fraction_proxy,float,27,27,0.8965 | 0.8925 | 0.7339,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,PO_backbone_contrast_flag,integer,27,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,single_stranded_ASO_context_flag,integer,27,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,LNA_gapmer_or_PS_ASO_context_flag,integer,27,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,transfection_concentration_nM_proxy,integer,27,2,50.0 | 100.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,PS_body_formation_score_proxy,float,27,27,0.7153 | 0.7071 | 0.432,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,nuclear_filament_context_score_proxy,float,27,27,0.5134 | 0.5089 | 0.3576,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,nucleolar_accumulation_score_proxy,float,27,27,0.4219 | 0.4182 | 0.2944,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,DNA_PKcs_binding_activation_score_proxy,float,27,27,0.7218 | 0.7144 | 0.457,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,ATM_binding_activation_score_proxy,float,27,27,0.6944 | 0.6868 | 0.4214,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,ATR_activation_score_proxy,float,27,27,0.4572 | 0.4522 | 0.2774,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,PARP1_binding_PARylation_score_proxy,float,27,27,0.7005 | 0.6933 | 0.4478,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,phase_separation_condensate_score_proxy,float,27,27,0.6722 | 0.6657 | 0.4456,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,DNA_break_independent_DDR_flag,integer,27,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,DNA_damage_marker_absent_from_PSBodies_context_flag,integer,27,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,cell_cycle_checkpoint_activation_score_proxy,float,27,27,0.5853 | 0.5801 | 0.3999,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,homologous_recombination_suppression_score_proxy,float,27,27,0.56 | 0.5536 | 0.3323,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,toxic_DNA_lesion_accumulation_score_proxy,float,27,27,0.4803 | 0.4761 | 0.3318,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,radiosensitivity_context_score_proxy,float,27,27,0.3585 | 0.3561 | 0.2724,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,sequence_independence_context_flag,integer,27,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,concentration_dependence_context_flag,integer,27,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,overall_ASO_DDR_toxicity_mechanism_score_proxy,float,27,27,0.6753 | 0.6681 | 0.4235,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,direct_oligotox_relevance,categorical,27,1,direct_mechanistic_ASO_toxicity_not_live,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,value_origin,categorical,27,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_aso_dna_damage_response.csv,assumption_id,categorical,27,1,ASM_043,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,antiviral_potency_score_proxy,float,15,5,0.91743 | 0.4717 | 0.36364,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,assumption_id,categorical,15,1,ASM_061,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,cell_model,categorical,15,1,MT4_HIV1_A6_infection_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,cell_viability_fraction_proxy,float,15,15,0.91634 | 0.92651 | 0.90449,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,challenge_gap_addressed,categorical,15,1,PS_LNA_modification_internalization_and_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,construct,categorical,15,5,PS_only_integrase_target | PS_LNA_5prime_integrase_target | PS_LNA_3prime_conserved_target,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,cytoplasmic_internalization_score_proxy,float,15,15,0.37933 | 0.58669 | 0.89668,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,ic50_uM_proxy,float,15,5,0.09 | 1.12 | 1.75,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,judging_alignment,categorical,15,1,Ability_to_Solve|Feasibility_and_Rigor,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,lna_terminal_modification_count,integer,15,3,0 | 1 | 2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,membrane_sorption_score_proxy,float,15,15,0.40598 | 0.67045 | 0.89485,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,modality,categorical,15,2,PS_ASO_vehicle_free | PS_LNA_ASO_vehicle_free,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,modeling_value,categorical,15,1,"supports ASO chemical-modification, upta",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,modification_tolerability_score_proxy,float,15,15,0.75524 | 0.82457 | 0.90215,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,module_record_id,string,15,15,supplemental_HIV_ASO_PS_only_integrase_t | supplemental_HIV_ASO_PS_only_integrase_t | supplemental_HIV_ASO_PS_only_integrase_t,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,phosphorothioate_flag,integer,15,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,source_id,categorical,15,1,GOTFRID_PS_LNA_HIV_ASO_ACTIVITY_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,source_role,categorical,15,1,supporting_ASO_chemistry_internalization,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,target_region,categorical,15,2,integrase | conserved_HIV_region,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,timepoint_h,integer,15,3,2 | 24 | 48,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,uptake_efficiency_score_proxy,float,15,15,0.39265 | 0.62857 | 0.89576,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,value_origin,categorical,15,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ps_lna_hiv_aso_internalization_toxicity.csv,vehicle_free_delivery_flag,integer,15,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,HSC_activation_score_proxy,float,6,6,0.68 | 0.84 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,PUM1_enriched_exosome_protection_proxy,float,6,6,0.18 | 0.12 | 0.14,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,PUM1_state,string,6,5,low | knockdown | high,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,TPM4_translation_suppression_axis,categorical,6,2,contextual | included,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,challenge_alignment,categorical,6,1,supports potential-impact and biological,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,fibrosis_relevance,categorical,6,1,supporting_MASLD_fibrosis_liver_injury_c,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,hepatocyte_lipid_deposition_score_proxy,float,6,6,0.78 | 0.86 | 0.83,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,hepatocyte_lipotoxic_death_score_proxy,float,6,6,0.7 | 0.82 | 0.77,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,liver_model_context,string,6,6,human_MASLD_liver | mouse_WD_CCl4 | mouse_CDAHFD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,module_id,categorical,6,1,PUM1_exosome_MASLD_HSC_fibrosis_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,notes,categorical,6,1,Supporting liver-biology context; not tr,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,oligo_or_RNA_tool_context,string,6,5,observational | AAV8_shPum1 | PUM1_upregulation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,scenario_id,string,6,6,MASLD_patient_low_PUM1 | WD_CCl4_AAV8_shPum1_aggravation | CDAHFD_AAV8_shPum1_aggravation,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,scenario_role,string,6,5,disease_context | injury_aggravation | hepatocyte_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,source_id,categorical,6,1,WAN_PUM1_EXOSOMES_MASLD_HSC_FIBROSIS_202,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
pum1_exosome_masld_hsc_fibrosis.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,assumption_id,categorical,6,1,ASM_106,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,delivery_or_targeting_score_proxy,float,6,6,0.22 | 0.42 | 0.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,mechanism_or_specificity_score_proxy,float,6,5,0.86 | 0.88 | 0.84,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,modality_or_platform,string,6,6,CRISPR_screen_context | siRNA_knockdown | siRNA_knockdown_or_indisulam,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,model_system,string,6,6,liver_derived_cell_lines | hepatocyte_polyIC_TLR3_model | viral_infection_liver_cell_models,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,modeling_role,string,6,6,innate_immunity_target_discovery_context | dsRNA_TLR3_response_modulation_context | viral_dsRNA_interferon_response_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,module_id,categorical,6,1,RBM39_hepatocyte_interferon_response_con,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,primary_effect_score_proxy,float,6,6,0.68 | 0.72 | 0.7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,scenario_id,string,6,6,genome_wide_TLR3_screen | RBM39_siRNA_knockdown_polyIC_response | viral_infection_ISG_response,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,source_id,categorical,6,1,LI_RBM39_HEPATOCYTE_IFN_INNATE_IMMUNITY_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,toxicity_or_safety_signal_proxy,float,6,5,0.24 | 0.3 | 0.32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rbm39_hepatocyte_innate_immunity.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
reviewed_not_encoded_sources.csv,source_id,string,1,1,BAO_ARSENIC_IRE1A_ALPHAKG_2025,Sources reviewed but not encoded as direct contributors to the schema.
reviewed_not_encoded_sources.csv,decision,string,1,1,not_encoded_in,Sources reviewed but not encoded as direct contributors to the schema.
reviewed_not_encoded_sources.csv,reason,string,1,1,Environmental arsenic developmental hepa,Sources reviewed but not encoded as direct contributors to the schema.
rna_nanoparticle_hcc_multitarget.csv,oligo_id,identifier,14,14,OLIGO_0000185 | OLIGO_0000198 | OLIGO_0000434,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,control_id,categorical,14,1,NON_CONTROL_GENERATED_RECORD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,source_id,categorical,14,1,SUN_HCC_RNA_NANOPARTICLE_MULTITARGET_202,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,target_gene,string,14,13,DGAT2 | BCL2 | CYP2E1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,modality,string,14,7,gapmer | GalNAc-siRNA | ASO_PNA_BROTHERS_duplex,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,Hep3B_liver_cancer_context_flag,integer,14,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,carrier_free_platform_flag,integer,14,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,hTERT_mRNA_knockdown_score_proxy,float,14,14,0.75574 | 0.84952 | 0.76193,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,BIRC5_mRNA_knockdown_score_proxy,float,14,14,0.77512 | 0.8713 | 0.78146,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,FGFR1_mRNA_knockdown_score_proxy,float,14,14,0.69761 | 0.78417 | 0.70332,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,proliferation_inhibition_score_proxy,float,14,14,0.73636 | 0.82774 | 0.74239,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,migration_inhibition_score_proxy,float,14,14,0.71698 | 0.80595 | 0.72286,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,apoptosis_induction_score_proxy,float,14,14,0.60072 | 0.67526 | 0.60564,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,xenograft_tumor_growth_inhibition_proxy,float,14,14,0.67823 | 0.76239 | 0.68378,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,non_cancer_cell_dose_window_score_proxy,float,14,14,0.56196 | 0.63169 | 0.56656,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,offtarget_toxicity_monitoring_score_proxy,float,14,14,0.69761 | 0.78417 | 0.70332,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,challenge_gap_addressed,categorical,14,1,carrier_free_RNAi_platform_liver_cell_ac,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,direct_oligotox_relevance,categorical,14,1,supporting_liver_RNAi_platform_safety_co,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,value_origin,categorical,14,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,assumption_id,categorical,14,1,ASM_048,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,hash_proxy,float,14,14,0.35888 | 0.94902 | 0.39411,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_nanoparticle_hcc_multitarget.csv,hash_proxy_2,float,14,14,0.16691 | 0.44223 | 0.91066,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,rna_payload_id,string,1120,1120,RNA_CTRL_OLIGO_NEG_VEHICLE_MOCK | RNA_CTRL_OLIGO_NEG_LOW_RISK | RNA_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,rna_payload_type,categorical,1120,6,single_siRNA | single_ASO | dual_siRNA_mRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,siRNA_payload_fraction,float,1120,47,1.0 | 0.0 | 0.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,mRNA_payload_fraction,float,1120,47,0.0 | 0.7 | 1.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,pcsk9_knockdown_pct_proxy,float,1120,467,14.25184 | 27.91866 | 4.05302,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,MHC_I_upregulation_fold_proxy,float,1120,1056,0.97161 | 1.60632 | 0.78655,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,antigen_presentation_fold_proxy,float,1120,1050,1.03137 | 1.46579 | 1.40284,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,rna_encapsulation_efficiency,float,1120,962,0.63973 | 0.80919 | 0.64498,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,immune_activation_score,float,1120,986,0.19703 | 0.04427 | 0.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,inflammatory_context_score,float,1120,1047,0.19337 | 0.08899 | 0.10056,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,payload_context_note,categorical,1120,1,payload/immunotherapy context; not a mea,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_payload_systems.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_targeted_therapeutics_platform.csv,assumption_id,categorical,6,1,ASM_130,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_targeted_therapeutics_platform.csv,delivery_interpretation_score_proxy,float,6,6,0.82 | 0.7 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_targeted_therapeutics_platform.csv,mechanistic_interpretation,string,6,6,sequence_specific_target_binding | protein_binding_distribution_RNaseH_or_s | sense_passenger_drug_delivery_device_Ago,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_targeted_therapeutics_platform.csv,modality_context,string,6,5,ASO_siRNA | ASO | siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_targeted_therapeutics_platform.csv,module_id,categorical,6,1,RNA_targeted_therapeutics_platform_logic,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_targeted_therapeutics_platform.csv,notes,string,6,6,Programmability supports rapid design bu | Single-stranded PS ASOs distribute diffe | The antisense guide is pharmacologically,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_targeted_therapeutics_platform.csv,platform_feature,string,6,6,Watson_Crick_programmability | ASO_single_stranded_structure | siRNA_double_stranded_prodrug,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_targeted_therapeutics_platform.csv,platform_rationale_score_proxy,float,6,6,0.92 | 0.82 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_targeted_therapeutics_platform.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_targeted_therapeutics_platform.csv,safety_modeling_complexity_score_proxy,float,6,6,0.54 | 0.62 | 0.6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_targeted_therapeutics_platform.csv,source_id,categorical,6,1,CROOKE_RNA_TARGETED_THERAPEUTICS_2018,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rna_targeted_therapeutics_platform.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,assumption_id,categorical,6,1,ASM_109,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,delivery_or_targeting_score_proxy,float,6,6,0.3 | 0.86 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,mechanism_or_specificity_score_proxy,float,6,5,0.86 | 0.88 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,modality_or_platform,string,6,6,AAV_shRNA | GalNAc-siRNA | single_stranded_oligonucleotide,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,model_system,string,6,6,hepatocyte_directed_AAV8_reporter | liver_AAV_transgene_control | RISC_decoy_reversal_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,modeling_role,string,6,6,vectorized_RNAi_cis_control_design | clinically_validated_liver_RNAi_control | reversible_RNAi_pharmacology_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,module_id,categorical,6,1,RNAi_REVERSIR_AAV_transgene_rheostat,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,primary_effect_score_proxy,float,6,5,0.66 | 0.76 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,scenario_id,string,6,6,self_silencing_AAV_shRNA_design | GalNAc_siRNA_transgene_silencing | REVERSIR_rescue_of_RNAi_activity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,source_id,categorical,6,1,SUBRAMANIAN_RNAI_RHEOSTAT_AAV_TRANSGENE_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,toxicity_or_safety_signal_proxy,float,6,3,0.18 | 0.16 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rnai_rheostat_aav_transgene_control.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,assumption_id,categorical,6,1,ASM_112,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,delivery_or_targeting_score_proxy,float,6,5,0.86 | 0.92 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,mechanism_or_specificity_score_proxy,float,6,5,0.84 | 0.9 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,modality_or_platform,string,6,3,GalNAc-LNA-ASO | RNaseH_LNA_ASO | clinical_ASO_safety,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,model_system,string,6,6,phase1_healthy_volunteers | population_PK_liver_exposure_model | liver_exposure_PD_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,modeling_role,string,6,6,clinical_single_dose_safety_and_transami | hepatic_uptake_saturation_and_extrahepat | target_knockdown_PKPD_modeling_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,module_id,categorical,6,1,RO7239958_GalNAc_LNA_ASO_clinical_PKPD_s,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,primary_effect_score_proxy,float,6,6,0.72 | 0.68 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,scenario_id,string,6,6,healthy_volunteer_single_ascending_dose | ASGPR_saturation_plasma_PK_signal | PAPD5_PAPD7_mRNA_knockdown_prediction,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,source_id,categorical,6,1,GERETTI_RO7239958_GALNAC_LNA_ASO_HBV_PHA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,toxicity_or_safety_signal_proxy,float,6,6,0.36 | 0.42 | 0.24,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ro7239958_galnac_lna_aso_hbv_phase1.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,assumption_id,categorical,6,1,ASM_102,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,challenge_alignment,categorical,6,1,"supporting module for oligo modality, de",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,delivery_or_targeting_score_proxy,float,6,6,0.2 | 0.42 | 0.44,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,mechanism_or_specificity_score_proxy,float,6,6,0.68 | 0.7 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,modality_or_platform,string,6,3,RPSAP52_non_coding_RNA_target | shRNA_context | LNA_GapmeR_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,model_system,string,6,6,EOC_patient_expression_context | ovarian_cancer_cell_lines | subcutaneous_ova15_or_skov3_models,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,modeling_role,string,6,6,noncoding_target_prioritization_context | target_validation_context | in_vivo_target_validation_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,module_id,categorical,6,1,RPSAP52_LNA_GapmeR_extrahepatic_oncology,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,primary_effect_score_proxy,float,6,5,0.72 | 0.76 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,scenario_id,string,6,6,tcga_expression_survival_context | lentiviral_RPSAP52_depletion_cell_growth | lentiviral_RPSAP52_depletion_in_vivo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,source_id,categorical,6,1,RAMESH_KUMAR_RPSAP52_LNA_GAPMER_OVARIAN_,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,toxicity_or_safety_signal_proxy,float,6,3,0.16 | 0.18 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
rpsap52_lna_gapmer_ovarian_pdox.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,oligo_id,identifier,28,28,OLIGO_0000007 | OLIGO_0000083 | OLIGO_0000095,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,control_id,categorical,28,1,NON_CONTROL_GENERATED_RECORD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,source_id,categorical,28,1,YAMAGUCHI_SCPBNA2_REDUCED_HEPATOTOX_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,target_gene,string,28,20,generic_RNaseH_ASO_target | APOB | generic_offtarget,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,modality,string,28,15,siRNA | ERBB2_DNA_aptamer | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,scpBNA2_or_mixed_scpBNA_scpBNA2_flag,integer,28,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,PS_fraction_proxy,float,28,28,0.61637 | 0.6409 | 0.65639,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,nuclease_stability_score_proxy,float,28,28,0.85496 | 0.88899 | 0.91047,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,target_RNA_knockdown_score_proxy,float,28,28,0.8152 | 0.84764 | 0.86813,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,ALT_fold_ULN_proxy,float,28,28,0.84502 | 0.87865 | 0.89989,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,AST_fold_ULN_proxy,float,28,28,0.89473 | 0.93033 | 0.95282,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,activity_safety_window_score_proxy,float,28,28,0.77543 | 0.80629 | 0.82578,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,direct_oligotox_relevance,categorical,28,1,direct_ASO_chemistry_hepatotoxicity_redu,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,value_origin,categorical,28,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,assumption_id,categorical,28,1,ASM_045,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
scpBNA2_aso_chemistry_safety.csv,hash_proxy,float,28,28,0.46069 | 0.73461 | 0.91768,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,sequence_toxicity_id,string,1120,1120,SEQTOX_CTRL_OLIGO_NEG_VEHICLE_MOCK | SEQTOX_CTRL_OLIGO_NEG_LOW_RISK | SEQTOX_CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,sequence_modification_toxicity_state,categorical,1120,5,baseline_sequence_toxicity_not_modeled | LNA_PS_gapmer_high_hepatotoxic_potential | sequence_redesign_lower_toxicity_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,lna_gapmer_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,phosphorothioate_full_backbone_context,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,dinucleotide_feature_encoding,categorical,1120,2,not_modeled | 64_dinucleotide_count_vector_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,toxic_gap_motif_count_proxy,integer,1120,11,0 | 1 | 9,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,protective_or_lower_risk_motif_count_proxy,integer,1120,17,0 | 14 | 6,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,model_family,categorical,1120,2,not_modeled | random_forest_style_dinucleotide_classif,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,training_set_oligo_count_proxy,integer,1120,2,0 | 206,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,screened_oligo_count_proxy,integer,1120,2,0 | 236,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,independent_validation_count_proxy,integer,1120,2,0 | 23,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,oob_accuracy_proxy,float,1120,2,0.0 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,validation_accuracy_proxy,float,1120,2,0.0 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,ALT_ULN_lowtox_threshold_fold_proxy,integer,1120,2,0.0 | 2.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,ALT_ULN_hightox_threshold_fold_proxy,integer,1120,2,0.0 | 5.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,predicted_sequence_hepatotoxicity_probability_proxy,float,1120,178,0.0 | 0.97633 | 0.98839,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,predicted_ALT_fold_from_sequence_model_proxy,float,1120,178,1.0 | 9.45655 | 10.18815,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,predicted_sequence_toxicity_class,categorical,1120,3,not_modeled | high_toxicity_potential | low_toxicity_potential,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,nearest_training_edit_distance_proxy,integer,1120,9,0 | 4 | 8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,prediction_confidence_by_distance_label,categorical,1120,4,not_modeled | medium_distance_moderate_confidence | far_distance_lower_confidence,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,prediction_accuracy_by_distance_proxy,float,1120,4,0.0 | 0.8 | 0.69,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,redesign_to_lower_toxicity_applicable,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,sequence_redesign_risk_reduction_proxy,float,1120,168,0.0 | 0.50842 | 0.72601,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,sequence_modification_toxicity_modifier,float,1120,178,0.0 | 0.93745 | 0.82256,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,context_note,categorical,1120,2,sequence/modification hepatotoxicity pre | sequence/modification toxicity context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sequence_modification_toxicity.csv,value_origin,categorical,1120,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,oligo_id,identifier,17,17,OLIGO_0000038 | OLIGO_0000157 | OLIGO_0000231,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,control_id,categorical,17,1,NON_CONTROL_GENERATED_RECORD,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,source_id,categorical,17,1,LIU_CYP2E1_LNP_APAP_AILI_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,target_gene,string,17,12,DGAT2 | generic_offtarget | PAPD7,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,modality,string,17,11,siCyp2e1_LNP | PS-ASO_DDR_toxicity_probe | long_acting_GalNAc_APOC3_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,APAP_acute_liver_injury_context_flag,integer,17,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,Cyp2e1_mRNA_knockdown_score_proxy,float,17,17,0.95757 | 0.92687 | 0.91553,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,serum_ALT_fold_ULN_proxy,float,17,17,1.19697 | 1.15858 | 1.14441,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,serum_AST_fold_ULN_proxy,float,17,17,1.24901 | 1.20896 | 1.19417,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,ROS_score_proxy,float,17,17,0.26021 | 0.25187 | 0.24879,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,overall_APAP_AILI_rescue_score_proxy,float,17,17,0.85349 | 0.82612 | 0.81602,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,direct_oligotox_relevance,categorical,17,1,direct_liver_injury_RNAi_intervention_co,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,value_origin,categorical,17,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,assumption_id,categorical,17,1,ASM_046,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
siCyp2e1_lnp_apap_aili.csv,hash_proxy,float,17,17,0.78611 | 0.55073 | 0.46737,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,sirna_bulge_state,categorical,1120,7,not_modeled | guide_passenger_1nt_bulge_tolerated | galnac_ttr_position14_bulge_in_vivo_acti,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,guide_strand_bulge_mode,categorical,1120,4,not_applicable | guide_passenger_duplex | guide_target_duplex_degenerate_target,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,bulge_length_nt_proxy,integer,1120,3,0 | 1 | 2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,bulge_position_guide_nt_proxy,integer,1120,18,0 | 13 | 14,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,bulge_region_label,categorical,1120,7,not_applicable | tolerated_nonseed_region | central_3prime_side_position14,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,guide_strand_sequence_unchanged_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,passenger_strand_shortening_design_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,modified_sirna_OMe_F_PS_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,galnac_conjugated_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,receptor_mediated_hepatocyte_uptake_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,melting_temperature_reduction_K_proxy,float,1120,238,0.0 | 14.0 | 10.53559,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,in_vitro_target_repression_score_proxy,float,1120,358,0.0 | 0.8093 | 0.93721,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,in_vivo_target_repression_score_proxy,float,1120,346,0.0 | 0.32645 | 0.8434,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,offtarget_degenerate_target_repression_score_proxy,float,1120,350,0.0 | 0.04427 | 0.14515,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,offtarget_prediction_include_deletions_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,seed_region_bulge_tolerability_score_proxy,float,1120,312,0.0 | 0.49133 | 0.71539,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,central_region_bulge_tolerability_score_proxy,float,1120,177,0.0 | 0.7 | 0.38312,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,terminal_region_bulge_tolerability_score_proxy,float,1120,281,0.0 | 0.61669 | 0.38418,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,bulge_related_offtarget_risk_modifier,float,1120,350,0.0 | 0.214 | 0.17,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,bulge_related_activity_modifier,float,1120,5,0.0 | 0.03 | -0.06,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,sirna_bulge_context_confidence_score,float,1120,364,0.0 | 0.74241 | 0.70953,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,context_note,categorical,1120,3,No siRNA bulge/off-target context assign | Supporting siRNA design/off-target-predi | Supporting siRNA bulge context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_bulge_offtarget_tolerance.csv,value_origin,categorical,1120,4,not_reported | literature_grounded_generated | inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,oligo_id,string,4,4,OLIGO_CTRL_CONTEXT_SIRNA_RISC_AGO2_MECHA | OLIGO_CTRL_CONTEXT_SIRNA_PKPD_BARRIERS | OLIGO_CTRL_CONTEXT_SIRNA_IMMUNE_OFFTARGE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,control_id,string,4,4,CTRL_CONTEXT_SIRNA_RISC_AGO2_MECHANISM | CTRL_CONTEXT_SIRNA_PKPD_BARRIERS | CTRL_CONTEXT_SIRNA_IMMUNE_OFFTARGET_SCRE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,source_id,categorical,4,1,RANASINGHE_SIRNA_PHARMACOLOGY_REVIEW_202,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,target_gene,string,4,4,RISC_AGO2_siRNA_mechanism_proxy | NAKED_SIRNA_PKPD_BARRIER_PROXY | SIRNA_IMMUNE_OFFTARGET_SCREENING_PROXY,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,modality,string,4,3,GalNAc-siRNA | naked-siRNA | siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,sequence_length,integer,4,1,21,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,dose,integer,4,2,5.0 | 25.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,hepatotox_score,float,4,4,0.8 | 2.4 | 4.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,hepatotoxicity_label,string,4,2,low | moderate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,value_origin,categorical,4,1,literature_grounded_generated_control,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,assumption_id,categorical,4,1,ASM_037,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,sirna_review_state,categorical,4,1,encoded,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,siRNA_duplex_structure_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,guide_strand_RISC_loading_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,AGO2_mRNA_cleavage_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,seed_region_nt2_8_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,central_region_nt9_12_cleavage_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,supplementary_region_nt13_17_context_flag,integer,4,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,naked_siRNA_rapid_renal_clearance_context_flag,integer,4,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,nuclease_degradation_barrier_score_proxy,float,4,3,0.18 | 0.78 | 0.28,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,endosomal_escape_limitation_score_proxy,float,4,2,0.7 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,chemical_stabilization_score_proxy,float,4,3,0.8944 | 0.724 | 0.7144,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,GalNAc_ASGPR_delivery_context_flag,integer,4,2,1 | 0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,LNP_delivery_context_flag,integer,4,1,0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,immune_activation_TLR_cytokine_risk_proxy,float,4,3,0.0516 | 0.306 | 0.1396,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,seed_region_offtarget_silencing_risk_proxy,float,4,4,0.204 | 0.616 | 0.76286,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,RISC_miRNA_pathway_competition_context_flag,integer,4,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,delivery_success_score_proxy,float,4,3,0.74 | 0.0 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,clinical_translation_context_score_proxy,float,4,3,0.4 | 0.2 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,approved_or_late_stage_siRNA_context_flag,integer,4,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirna_pharmacology_clinical_development_context.csv,sirna_pharmacology_context_confidence_score,float,4,1,0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,oligo_id,identifier,11,11,OLIGO_0000050 | OLIGO_0000097 | OLIGO_0000188,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,control_id,categorical,11,4,NON_CONTROL_GENERATED_RECORD | CTRL_NEG_SIRUBICON_ROS_GALNAC_LIVER_FUNC | CTRL_CONTEXT_ROS_GALNAC_HEPATOCYTE_TARGE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,source_id,categorical,11,1,LAN_SIRUBICON_ROS_GALNAC_MASH_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,target_gene,categorical,11,1,RUBICON,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,modality,categorical,11,1,ROS-responsive_GalNAc-siRNA_nanoparticle,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,delivery_platform,categorical,11,1,PPH-PEI_GalNAc_siRNA_generated_proxy,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,ROS_responsive_shell_flag,integer,11,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,PEI25k_GalNAc_core_flag,integer,11,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,GalNAc_ASGPR_hepatocyte_targeting_flag,integer,11,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,PEGylated_negative_surface_circulation_flag,integer,11,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,MASH_oxidative_microenvironment_context_flag,integer,11,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,ROS_triggered_shell_disassembly_score_proxy,float,11,11,0.867 | 0.6704 | 0.8883,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,ASGPR_hepatocyte_uptake_score_proxy,float,11,11,0.9341 | 0.878 | 0.7606,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,hepatocyte_selectivity_score_proxy,float,11,11,0.9483 | 0.8792 | 0.9234,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,nonparenchymal_cell_sparing_score_proxy,float,11,11,0.744 | 0.7299 | 0.7342,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,Rubicon_knockdown_score_proxy,float,11,11,0.8466 | 0.7671 | 0.839,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,lipophagy_activation_score_proxy,float,11,11,0.7249 | 0.6756 | 0.7202,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,hepatic_steatosis_reduction_score_proxy,float,11,11,0.6149 | 0.5854 | 0.6121,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,ALT_relative_to_MASH_control_proxy,float,11,11,0.8548 | 0.8644 | 0.8564,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,AST_relative_to_MASH_control_proxy,float,11,11,0.8932 | 0.9019 | 0.8948,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,albumin_relative_to_MASH_control_proxy,float,11,10,1.1158 | 1.1108 | 1.1152,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,liver_accumulation_score_proxy,float,11,11,0.8495 | 0.7747 | 0.8576,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,lung_accumulation_monitoring_score_proxy,float,11,11,0.3131 | 0.2119 | 0.324,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,heart_kidney_change_low_context_flag,integer,11,1,1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,offtarget_organ_retention_score_proxy,float,11,11,0.3159 | 0.2316 | 0.325,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,PEI_cationic_vector_cytotoxicity_monitoring_score_proxy,float,11,11,0.1432 | 0.1263 | 0.145,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,nanocarrier_immune_clearance_monitoring_score_proxy,float,11,11,0.2021 | 0.1802 | 0.2045,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,overall_delivery_benefit_minus_safety_risk_score_proxy,float,11,11,0.4921 | 0.4754 | 0.4825,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,direct_oligotox_relevance,categorical,11,1,supporting_liver_targeted_siRNA_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,value_origin,categorical,11,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sirubicon_ros_galnac_mash_delivery.csv,assumption_id,categorical,11,1,ASM_044,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,ALP_signal_score_proxy,float,7,7,0.05 | 0.12 | 0.16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,ALT_signal_score_proxy,float,7,7,0.08 | 0.16 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,challenge_alignment,categorical,7,1,directly supports ability-to-solve and r,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,immune_or_complement_activation_score_proxy,float,7,6,0.02 | 0.08 | 0.1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,microscopic_platform_effect_score_proxy,float,7,6,0.03 | 0.12 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,modeling_role,string,7,7,specific_target_knockdown_no_relevant_of | liver_targeted_distribution | known_platform_distribution_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,module_id,categorical,7,1,SLN360_GalNAc_siRNA_preclinical_toxicolo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,notes,categorical,7,1,Generated preclinical-safety scenario ro,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,offtarget_screening_included,categorical,7,1,yes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,oligo_modality,categorical,7,1,GalNAc_conjugated_siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,primary_tissue_or_matrix,string,7,6,primary_human_hepatocyte | liver | kidney,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,reversibility_or_nonadverse_label,categorical,7,1,reversible_or_nonadverse,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,scenario_id,string,7,7,primary_human_hepatocyte_specificity | rat_liver_distribution_peak | rat_kidney_distribution_peak,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,source_id,categorical,7,1,RIDER_SLN360_LPA_GALNAC_SIRNA_PRECLINICA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,species_relevance,categorical,7,1,human|rat|cynomolgus_monkey,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,study_context,string,7,6,in_vitro | rat_PK_TK | rat_toxicology,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,target_knockdown_or_PD_score_proxy,float,7,7,0.9 | 0.78 | 0.58,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,target_or_safety_endpoint,string,7,7,LPA_mRNA | LPA_surrogate_context | non_target_distribution,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sln360_galnac_sirna_preclinical_toxicology.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,aso_chemistry_context,string,6,6,PS_DNA_gapmer | SNA2_PS_gapmer | SNA4_PS_gapmer,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,challenge_alignment,categorical,6,1,"supports chemistry/delivery coverage, sy",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,liver_damage_liability_score_proxy,float,6,6,0.18 | 0.14 | 0.13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,module_id,categorical,6,1,SNA_ASO_systemic_delivery_safety_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,notes,categorical,6,1,Supporting ASO chemistry and systemic sa,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,nuclease_resistance_score_proxy,float,6,6,0.4 | 0.72 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,organ_uptake_score_proxy,float,6,6,0.34 | 0.7 | 0.8,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,pharmacodynamic_glucosuria_score_proxy,float,6,6,0.3 | 0.63 | 0.73,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,primary_organ_context,string,6,4,kidney_proximal_tubule | kidney_and_liver | renal_proximal_tubule,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,rnaseH1_gapmer_mechanism_context,categorical,6,1,yes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,safety_interpretation,categorical,6,2,no_severe_liver_damage_proxy | higher_liver_damage_comparator,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,scenario_id,string,6,6,SGLT2_DNA_ASO_reference | SGLT2_SNA2_ASO | SGLT2_SNA4_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,scenario_role,string,6,6,reference_ASO | improved_stability_and_activity | high_renal_uptake_and_prolonged_activity,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,source_id,categorical,6,1,TSUBOI_SNA_ASO_SGLT2_KIDNEY_SYSTEMIC_SAF,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,target_gene,categorical,6,1,SGLT2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,target_knockdown_score_proxy,float,6,6,0.38 | 0.68 | 0.77,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sna_aso_kidney_systemic_safety.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
source_corpus_access_statement.csv,assumption_id,identifier,1,1,ASM_131,Statement of source corpus access boundary (open-access only).
source_corpus_access_statement.csv,future_work_note,string,1,1,Paywalled or inaccessible papers are not,Statement of source corpus access boundary (open-access only).
source_corpus_access_statement.csv,original_filenames_in_outputs,string,1,1,no,Statement of source corpus access boundary (open-access only).
source_corpus_access_statement.csv,pdf_uploads_total_in_conversation_after_supplement,integer,1,1,151,Statement of source corpus access boundary (open-access only).
source_corpus_access_statement.csv,source_identifier_policy,string,1,1,paper_title_short_title_source_id_only,Statement of source corpus access boundary (open-access only).
source_corpus_access_statement.csv,statement,string,1,1,The source corpus for this version was a,Statement of source corpus access boundary (open-access only).
source_corpus_access_statement.csv,statement_id,string,1,1,CORPUS_ACCESS_BOUNDARY,Statement of source corpus access boundary (open-access only).
source_corpus_access_statement.csv,statement_type,string,1,1,source_corpus_boundary,Statement of source corpus access boundary (open-access only).
source_corpus_access_statement.csv,supplemental_pdf_count,integer,1,1,8,Statement of source corpus access boundary (open-access only).
source_corpus_access_statement.csv,supplemental_pdf_size_mb_title_based,float,1,1,23.28627,Statement of source corpus access boundary (open-access only).
source_triage_log.csv,decision,categorical,5,2,defer | add_supporting,"Documentation of source-level inclusion, deferral, and exclusion decisions."
source_triage_log.csv,judging_use,categorical,144,1,supports rigor/transparency by documenti,"Documentation of source-level inclusion, deferral, and exclusion decisions."
source_triage_log.csv,license_or_access,string,144,79,DBbun-authored working memo | Creative Commons Attribution | CC BY 4.0,"Documentation of source-level inclusion, deferral, and exclusion decisions."
source_triage_log.csv,module_added,string,5,3,no | rpsap52_lna_gapmer_ovarian_pdox.csv | biologics_hyb_targeted_rna_delivery.csv,"Documentation of source-level inclusion, deferral, and exclusion decisions."
source_triage_log.csv,phase2_fit,string,5,5,low_to_moderate_context_only | low_context_only | moderate_supporting_ASO_modality_safety,"Documentation of source-level inclusion, deferral, and exclusion decisions."
source_triage_log.csv,reason,string,149,149,"Defines target tables, predictors, contr | Adds PNPLA3 I148M genotype context, homo | Strengthened from uploaded paper: phase ","Documentation of source-level inclusion, deferral, and exclusion decisions."
source_triage_log.csv,source_id,string,149,144,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | PNPLA3_ROMEO_VALENTI_2025 | RAPIROSIRAN_SANYAL_2025,"Documentation of source-level inclusion, deferral, and exclusion decisions."
source_triage_log.csv,source_type,string,144,131,alignment_memo | review_open_access | phase1_randomized_double_blind_clinical_,"Documentation of source-level inclusion, deferral, and exclusion decisions."
source_triage_log.csv,title,string,144,142,DBbun OligoTox Phase 2 Alignment Memo | Fifteen Years of PNPLA3: Transforming He | Phase I randomized double-blind study of,"Documentation of source-level inclusion, deferral, and exclusion decisions."
source_triage_log.csv,triage_decision,categorical,144,4,include_context_metadata | include_supporting_module_or_context | include_full_or_direct_module,"Documentation of source-level inclusion, deferral, and exclusion decisions."
sources.csv,source_id,string,144,144,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | PNPLA3_ROMEO_VALENTI_2025 | RAPIROSIRAN_SANYAL_2025,"Literature source metadata: paper titles, source IDs, relevance category, license."
sources.csv,title,string,144,142,DBbun OligoTox Phase 2 Alignment Memo | Fifteen Years of PNPLA3: Transforming He | Phase I randomized double-blind study of,"Literature source metadata: paper titles, source IDs, relevance category, license."
sources.csv,year,integer,144,12,2026 | 2025 | 2023,"Literature source metadata: paper titles, source IDs, relevance category, license."
sources.csv,source_type,string,144,131,alignment_memo | review_open_access | phase1_randomized_double_blind_clinical_,"Literature source metadata: paper titles, source IDs, relevance category, license."
sources.csv,doi_or_url,string,144,142,internal_db_bun_alignment_memo | 10.1111/liv.70240 | 10.1016/j.jhep.2025.05.031,"Literature source metadata: paper titles, source IDs, relevance category, license."
sources.csv,license_or_access,string,144,79,DBbun-authored working memo | Creative Commons Attribution | CC BY 4.0,"Literature source metadata: paper titles, source IDs, relevance category, license."
sources.csv,source_role,string,144,142,governing_schema_and_rules | PNPLA3_precision_genetics_siRNA_ASO_ther | HSD17B13_GalNAc_siRNA_clinical_PK_PD_liv,"Literature source metadata: paper titles, source IDs, relevance category, license."
sources.csv,modality_focus,string,144,144,ASO|gapmer|siRNA|GalNAc-siRNA | siRNA|ASO | GalNAc-siRNA|HSD17B13|rapirosiran|MASH|A,"Literature source metadata: paper titles, source IDs, relevance category, license."
sources.csv,hepatotoxicity_relevance,string,144,143,governing | supporting_liver_genetics_MASLD_precisio | directly_relevant_clinical_low_DILI_GalN,"Literature source metadata: paper titles, source IDs, relevance category, license."
sources.csv,use_in_core_dataset,string,144,52,yes | supporting | yes_core_clinical_PK_PD_safety_module,"Literature source metadata: paper titles, source IDs, relevance category, license."
sources.csv,notes,string,144,144,"Defines target tables, predictors, contr | Adds PNPLA3 I148M genotype context, homo | Strengthened from uploaded paper: phase ","Literature source metadata: paper titles, source IDs, relevance category, license."
sources.csv,record_origin,categorical,144,1,source_metadata,"Literature source metadata: paper titles, source IDs, relevance category, license."
sources.csv,original_pdf_redistributed,categorical,144,1,no,"Literature source metadata: paper titles, source IDs, relevance category, license."
sources.csv,license_for_generated_output,categorical,144,1,CC BY 4.0,"Literature source metadata: paper titles, source IDs, relevance category, license."
sptlc2_lnp_sirna_mash_ceramide.csv,assumption_id,categorical,6,1,ASM_116,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,delivery_or_targeting_score_proxy,float,6,5,0.28 | 0.84 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,mechanism_or_specificity_score_proxy,float,6,4,0.88 | 0.82 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,modality_or_platform,categorical,6,2,target_discovery_context | LNP-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,model_system,string,6,6,human_MASLD_MASH_liver_lipidomics_snRNAs | hepatocyte_targeted_delivery_model | MASH_mouse_liver_lipidomics,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,modeling_role,string,6,6,human_liver_target_prioritization_contex | hepatocyte_delivery_and_knockdown_contex | mechanistic_lipid_toxicity_readout,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,module_id,categorical,6,1,SPTLC2_LNP_siRNA_MASH_ceramide_liver_mod,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,primary_effect_score_proxy,float,6,6,0.78 | 0.86 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,scenario_id,string,6,6,human_MASLD_ceramide_SPTLC2_signal | LNP_SPTLC2_siRNA_hepatocyte_delivery | hepatic_ceramide_reduction,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,source_id,categorical,6,1,YU_SPTLC2_LNP_SIRNA_MASH_CERAMIDE_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,toxicity_or_safety_signal_proxy,float,6,4,0.3 | 0.22 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
sptlc2_lnp_sirna_mash_ceramide.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
supplemental_source_decisions.csv,access_basis,categorical,8,1,open_access_or_freely_downloadable_pdf_a,Supplemental literature triage decisions and reasoning.
supplemental_source_decisions.csv,doi_or_url,string,8,8,10.1089/nat.2024.0090 | 10.1093/nar/gkad067 | 10.1016/j.jhep.2024.12.046,Supplemental literature triage decisions and reasoning.
supplemental_source_decisions.csv,filename_stored_or_displayed,categorical,8,1,no,Supplemental literature triage decisions and reasoning.
supplemental_source_decisions.csv,incorporation_decision,string,8,5,row_level_module_added | row_level_reference_module_added | platform_module_added,Supplemental literature triage decisions and reasoning.
supplemental_source_decisions.csv,module_or_table,string,8,7,galnac_sirna_risc_offtarget_mechanism.cs | approved_oligo_chemistry_landscape.csv | pnpla3_azd2693_precision_mash.csv,Supplemental literature triage decisions and reasoning.
supplemental_source_decisions.csv,paper_title,string,8,8,"Mechanistic Insights into Hybridization- | Chemistry, Structure and Function of App | AZD2693, a PNPLA3 antisense oligonucleot",Supplemental literature triage decisions and reasoning.
supplemental_source_decisions.csv,rationale,string,8,8,High-priority mechanistic source for AGO | Standardizes approved-oligo chemistry an | Original clinical/preclinical PNPLA3 ASO,Supplemental literature triage decisions and reasoning.
supplemental_source_decisions.csv,short_title,string,8,8,agarwal-galnac-sirna-offtarget-2025 | egli-manoharan-approved-oligo-chemistry- | armisen-azd2693-pnpla3-aso-mash-2025,Supplemental literature triage decisions and reasoning.
supplemental_source_decisions.csv,source_category,string,8,5,core | core_reference | supporting,Supplemental literature triage decisions and reasoning.
supplemental_source_decisions.csv,source_id,string,8,8,AGARWAL_GALNAC_SIRNA_OFFTARGET_2025 | EGLI_MANOHARAN_APPROVED_OLIGO_CHEMISTRY_ | ARMISEN_AZD2693_PNPLA3_ASO_MASH_2025,Supplemental literature triage decisions and reasoning.
supplemental_source_decisions.csv,source_pdf_size_mb,float,8,8,1.64399 | 10.07143 | 1.27878,Supplemental literature triage decisions and reasoning.
supplemental_source_decisions.csv,value_origin,categorical,8,1,source_inventory_metadata,Supplemental literature triage decisions and reasoning.
supplemental_source_decisions.csv,year,integer,8,5,2025 | 2023 | 2018,Supplemental literature triage decisions and reasoning.
systemic_hdo_drg_sciatic_delivery.csv,RNase_H1_release_logic,categorical,7,2,direct_ASO_RNase_H1_target_degradation | cRNA_cleavage_releases_ASO_then_RNase_H1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,challenge_alignment,categorical,7,1,supports impact and rigor by adding olig,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,delivery_ligand_or_duplex_design,categorical,7,2,single_stranded_parent_gapmer_ASO | alpha_tocopherol_conjugated_cRNA_duplexe,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,dose_regimen,categorical,7,3,single | weekly_x4 | systemic,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,extrahepatic_distribution_score_proxy,float,7,7,0.2 | 0.42 | 0.22,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,modeling_role,string,7,7,parent_ASO_reference | enhanced_HDO_delivery | parent_repeated_reference,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,module_id,categorical,7,1,systemic_Toc_HDO_DRG_sciatic_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,nominal_ASO_equivalent_dose_mg_per_kg,float,7,2,50.0 | 12.5,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,notes,categorical,7,1,Generated delivery scenario row; proxy v,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,oligo_modality,categorical,7,2,ASO | Toc_HDO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,potency_improvement_vs_parent_ASO_score_proxy,float,7,6,0.2 | 0.38 | 0.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,provenance_label,categorical,7,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,safety_modeling_relevance,categorical,7,1,adds_extrahepatic_biodistribution_and_pe,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,scenario_id,string,7,7,Malat1_parent_ASO_single_50mgkg_lumbar_D | Malat1_Toc_HDO_single_50mgkg_lumbar_DRG | Malat1_parent_ASO_repeated_12_5mgkg_cerv,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,source_id,categorical,7,1,KABURAGI_TOC_HDO_DRG_SCIATIC_SYSTEMIC_DE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,target_knockdown_score_proxy,float,7,7,0.55 | 0.86 | 0.58,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,target_tissue,string,7,5,lumbar_DRG | cervical_DRG | lumbar_and_cervical_DRG,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,target_transcript,string,7,4,Malat1 | Dmpk | Scarb1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
systemic_hdo_drg_sciatic_delivery.csv,value_origin,categorical,7,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,assumption_id,categorical,6,1,ASM_121,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,delivery_or_targeting_score_proxy,float,6,4,0.86 | 0.88 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,mechanism_or_specificity_score_proxy,float,6,5,0.82 | 0.84 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,modality_or_platform,string,6,6,hybrid_lipid_nanovesicle_siRNA_delivery | siRNA_delivery | delivery_mechanism,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,model_system,string,6,6,HCC_TDEV_membrane_DPPC_LEV_platform | Sk_hep1_HCC_parent_cell_homing_model | HCC_cell_internalization_pathway,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,modeling_role,string,6,6,advanced_delivery_vehicle_design_context | tumor_selective_delivery_context | cell_entry_mechanism_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,module_id,categorical,6,1,TDEV_membrane_hybrid_lipid_nanovesicle_s,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,primary_effect_score_proxy,float,6,5,0.7 | 0.76 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,scenario_id,string,6,6,TDEV_membrane_hybrid_LEV_design | parent_HCC_tumor_homing | HSPG_mediated_internalization,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,source_id,categorical,6,1,ZHOU_TDEV_MEMBRANE_LEV_SIRNA_HCC_DELIVER,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,toxicity_or_safety_signal_proxy,float,6,4,0.24 | 0.22 | 0.2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tdev_membrane_lev_sirna_hcc_delivery.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,assumption_id,categorical,6,1,ASM_119,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,delivery_or_targeting_score_proxy,float,6,5,0.16 | 0.32 | 0.3,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,mechanism_or_specificity_score_proxy,float,6,5,0.78 | 0.86 | 0.88,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,modality_or_platform,string,6,5,liver_injury_context | siRNA_knockdown | protein_crosslinking_mechanism,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,model_system,string,6,6,HepG2_and_primary_hepatocyte_GCDCA_model | GCDCA_treated_HepG2_cells | keratin_hepatocyte_death_model,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,modeling_role,string,6,6,cholestatic_bile_acid_apoptosis_readout_ | mechanistic_knockdown_reversal_context | cytoskeletal_apoptosis_pathway_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,module_id,categorical,6,1,TG1_TG2_K18_K8_bile_acid_hepatocyte_apop,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,primary_effect_score_proxy,float,6,6,0.7 | 0.74 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,scenario_id,string,6,6,GCDCA_dose_dependent_hepatocyte_apoptosi | TG1_TG2_siRNA_apoptosis_attenuation | K18_K8_siRNA_protective_effect,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,source_id,categorical,6,1,TATSUKAWA_TG_KERATIN_BILE_ACID_HEPATOCYT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,toxicity_or_safety_signal_proxy,float,6,6,0.58 | 0.34 | 0.36,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
tg_keratin_bile_acid_hepatocyte_death.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,assumption_id,categorical,6,1,ASM_118,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,delivery_or_targeting_score_proxy,float,6,4,0.2 | 0.18 | 0.36,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,mechanism_or_specificity_score_proxy,float,6,3,0.82 | 0.84 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,modality_or_platform,string,6,6,proteomics_biomarker_context | biomarker_context | siRNA_knockdown,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,model_system,string,6,6,rat_radiation_induced_liver_injury | radiation_dose_RILI_plasma_liver_correla | BRL_BRL3A_THLE2_hepatocyte_models,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,modeling_role,string,6,6,liver_injury_biomarker_discovery_context | injury_monitoring_readout_context | mechanistic_target_validation_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,module_id,categorical,6,1,THBS1_RILI_proteomics_siRNA_fibrosis_mod,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,primary_effect_score_proxy,float,6,5,0.72 | 0.76 | 0.74,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,scenario_id,string,6,6,RILI_TMT_proteomics_biomarker_screen | THBS1_plasma_tissue_dose_response | THBS1_siRNA_knockdown_hepatocytes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,source_id,categorical,6,1,WANG_THBS1_RILI_PROTEOMICS_SIRNA_2025,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,toxicity_or_safety_signal_proxy,float,6,6,0.42 | 0.48 | 0.32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
thbs1_rili_proteomics_sirna.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
toxicity_readouts.csv,readout_id,string,16800,16800,READ_CTRL_OLIGO_NEG_VEHICLE_MOCK_T24_R1 | READ_CTRL_OLIGO_NEG_VEHICLE_MOCK_T24_R2 | READ_CTRL_OLIGO_NEG_VEHICLE_MOCK_T24_R3,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,assay_id,string,16800,5600,ASSAY_CTRL_OLIGO_NEG_VEHICLE_MOCK_T24 | ASSAY_CTRL_OLIGO_NEG_VEHICLE_MOCK_T72 | ASSAY_CTRL_OLIGO_NEG_VEHICLE_MOCK_T168,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,oligo_id,string,16800,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,source_id,string,16800,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,control_id,string,16800,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,time_hours,integer,16800,5,24 | 72 | 168,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,replicate_id,integer,16800,3,1 | 2 | 3,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,viability_pct,float,16800,16800,85.99561595094147 | 91.06775186321384 | 85.49070622192647,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,ALT_AST_proxy_fold_change,float,16800,16800,1.9788627647805892 | 1.5715849901010643 | 1.626738080633759,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,apoptosis_score,float,16800,16800,0.298932836512114 | 0.2977209242066459 | 0.3577897617808117,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,stress_response_score,float,16800,16800,0.3283811496058296 | 0.3425986449232235 | 0.5688441746526677,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,transcriptomic_perturbation_score,float,16800,16795,0.2396605765951162 | 0.2399277160889206 | 0.3171385261514008,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,immune_activation_score,float,16800,15136,0.2154366846768191 | 0.1827922881801677 | 0.1664045783582166,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,inflammatory_context_score,float,16800,16021,0.236647832095342 | 0.1996169007156055 | 0.2366170013904089,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,overall_hepatotoxicity_risk_score,float,16800,16800,2.6518167631613823 | 2.2405881055627197 | 2.8658984364223388,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,hepatotoxicity_label,categorical,16800,3,low | moderate | high,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,measured_experimental_value,categorical,16800,1,no,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,record_origin,categorical,16800,1,dbbun_generated,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,value_origin,categorical,16800,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,provenance_label,categorical,16800,3,literature_grounded_generated | inferred_from_paper | literature_grounded_generated_control,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,assumption_id,identifier,16800,30,ASM_007 | ASM_018 | ASM_019,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
toxicity_readouts.csv,confidence_level,float,16800,936,0.88 | 0.9 | 0.82,"Replicate-level toxicity readouts: viability, ALT/AST proxy, apoptosis, stress response, transcriptomic perturbation, immune activation, inflammatory context, overall risk score, hepatotoxicity label."
trim16_yap1_nrf2_septic_liver_injury.csv,assumption_id,categorical,6,1,ASM_120,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,challenge_alignment,categorical,6,1,supports in silico oligo-toxicity modeli,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,delivery_or_targeting_score_proxy,float,6,6,0.18 | 0.34 | 0.52,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,mechanism_or_specificity_score_proxy,float,6,4,0.82 | 0.84 | 0.86,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,modality_or_platform,string,6,6,liver_injury_context | siRNA_knockdown | AAV9_overexpression,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,model_system,string,6,6,LPS_injured_hepatocyte_model | LPS_hepatocyte_injury_model | CLP_septic_liver_injury_mouse,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,modeling_role,string,6,6,acute_inflammatory_hepatocyte_stress_con | knockdown_worsening_safety_axis_context | rescue_and_liver_function_boundary_conte,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,module_id,categorical,6,1,TRIM16_YAP1_NRF2_septic_liver_injury_mod,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,primary_effect_score_proxy,float,6,5,0.68 | 0.7 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,scenario_id,string,6,6,LPS_reduces_TRIM16_hepatocyte_stress | TRIM16_siRNA_exacerbates_ALT_AST | TRIM16_overexpression_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,source_id,categorical,6,1,ZHANG_TRIM16_YAP1_NRF2_SEPTIC_LIVER_INJU,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,toxicity_or_safety_signal_proxy,float,6,6,0.54 | 0.58 | 0.28,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trim16_yap1_nrf2_septic_liver_injury.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,assumption_id,categorical,5,1,ASM_083,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,cellular_uptake_score_proxy,float,5,5,0.1 | 0.65 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,challenge_alignment,categorical,5,1,supports impact by adding an alternative,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,cytotoxicity_score_proxy,float,5,4,0.1 | 0.22 | 0.12,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,delivery_efficiency_score_proxy,float,5,5,0.1 | 0.55 | 0.82,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,delivery_strategy,string,5,5,none | commercial_lipofection | trivalent_disulfide_masked,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,endocytosis_independent_context,categorical,5,2,no_or_not_primary | yes,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,liver_distribution_context,categorical,5,2,yes | not_primary_endpoint,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,model_system,categorical,5,2,HeLa_S3 | mouse_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,modeling_role,string,5,5,negative_delivery_reference | commercial_delivery_comparator | enhanced_delivery_candidate,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,module_id,categorical,5,1,trivalent_disulfide_ODN_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,notes,categorical,5,1,Generated delivery-chemistry scenario ro,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,observed_toxicity_score_proxy,float,5,5,0.05 | 0.2 | 0.16,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,payload_or_probe,categorical,5,2,ODN_FAM | SS-ODN_FAM,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,provenance_label,categorical,5,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,scenario_id,string,5,5,ODN_FAM_no_delivery | Lipo2000_ODN_FAM | SS_ODN_FAM_trivalent_disulfide,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,source_id,categorical,5,1,WANG_TRIVALENT_DISULFIDE_MASKED_ODN_DELI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,thiol_exchange_dependency_score_proxy,float,5,5,0.05 | 0.25 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
trivalent_disulfide_odn_delivery.csv,value_origin,categorical,5,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,assumption_id,categorical,6,1,ASM_100,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,challenge_alignment,categorical,6,1,"supporting module for delivery, immune-c",Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,delivery_or_targeting_score_proxy,float,6,6,0.9 | 0.75 | 0.65,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,immune_or_cell_state_score_proxy,float,6,6,0.55 | 0.5 | 0.68,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,modality_or_platform,string,6,3,TY1_C2_casein_chitosan_micelles | TY1_C2_oral | C2_formulated_ASO,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,model_system,string,6,6,in_vitro_formulation | healthy_mouse | rat_myocardial_infarction,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,modeling_role,string,6,6,encapsulation_and_enzyme_protection | tolerability_liver_enzyme_histology_cont | disease_modifying_activity_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,module_id,categorical,6,1,TY1_oral_ncRNA_macrophage_delivery,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,notes,categorical,6,1,Generated qualitative scenario row; prox,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,primary_effect_score_proxy,float,6,6,0.95 | 0.8 | 0.72,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,scenario_id,string,6,6,TY1C2_encapsulation_protection | healthy_mouse_chronic_oral_tolerability | rat_MI_single_oral_dose,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,source_id,categorical,6,1,YAMAGUCHI_TY1_ORAL_NCRNA_MACROPHAGE_C2_2,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,toxicity_or_safety_signal_proxy,float,6,5,0.12 | 0.1 | 0.18,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
ty1_oral_ncrna_macrophage_delivery.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
validation_summary.csv,metric,string,385,27,row_count | hepatotoxicity_label_count | control_present_in_oligos,"Automated validation checks: row counts, identifier mapping, range checks, schema consistency."
validation_summary.csv,status,categorical,385,3,ok | warning_missing | review_needed,"Automated validation checks: row counts, identifier mapping, range checks, schema consistency."
validation_summary.csv,table_name,string,385,126,sources.csv | controls.csv | oligos.csv,"Automated validation checks: row counts, identifier mapping, range checks, schema consistency."
validation_summary.csv,value,string,385,288,144 | 161 | 1120,"Automated validation checks: row counts, identifier mapping, range checks, schema consistency."
xist_hsc_ferroptosis_fibrosis.csv,ALT_AST_liver_injury_score_proxy,float,6,6,0.18 | 0.82 | 0.42,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,GPX4_activity_score_proxy,float,6,6,0.18 | 0.85 | 0.38,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,HSC_activation_score_proxy,float,6,6,0.15 | 0.8 | 0.32,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,RNA_axis,categorical,6,1,lncRNA_XIST_sponges_miR-663a_to_upregula,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,challenge_alignment,categorical,6,1,supports potential impact and biological,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,ferroptosis_score_proxy,float,6,6,0.25 | 0.2 | 0.78,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,fibrosis_score_proxy,float,6,6,0.1 | 0.82 | 0.4,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,hydroxyproline_HYP_fibrosis_score_proxy,float,6,6,0.1 | 0.75 | 0.35,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,intervention_or_perturbation,string,6,6,none | ethanol | si-XIST,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,model_system,categorical,6,2,LX-2_HSC | mouse_liver,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,modeling_role,string,6,6,baseline_control | activated_HSC_positive_context | XIST_knockdown_ferroptosis_rescue,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,module_id,categorical,6,1,XIST_miR663a_GPX4_HSC_ferroptosis_fibros,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,notes,categorical,6,1,Generated fibrosis/ferroptosis scenario ,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,oligo_or_RNA_tool,categorical,6,2,none | siRNA_or_shRNA_or_miRNA_antagonist,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,provenance_label,categorical,6,1,inferred_from_paper,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,readout_family,categorical,6,1,alpha_SMA|CoL1A1|GPX4|Fe2+|MDA|GSH|ALT|A,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,scenario_id,string,6,6,control_LX2 | ethanol_activated_LX2 | ethanol_si_XIST,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,source_id,categorical,6,1,DAI_XIST_MIR663A_GPX4_HSC_FERROPTOSIS_FI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,study_context,categorical,6,2,in_vitro | in_vivo,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
xist_hsc_ferroptosis_fibrosis.csv,value_origin,categorical,6,1,literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,oligo_id,string,1120,1120,CTRL_OLIGO_NEG_VEHICLE_MOCK | CTRL_OLIGO_NEG_LOW_RISK | CTRL_OLIGO_NEG_RAPIROSIRAN_LIKE,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,source_id,string,1120,83,MEMO_OLIGOTOX_PHASE2_ALIGNMENT | RAPIROSIRAN_SANYAL_2025 | LIVER_SPHEROID_SCHOLTEN_2026,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,control_id,string,1120,121,CTRL_NEG_VEHICLE_MOCK | CTRL_NEG_LOW_RISK_OLIGO | CTRL_NEG_CLINICAL_LOW_HEPATOTOX_RAPIROSI,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,oligo_modality,string,1120,71,vehicle_mock | siRNA | GalNAc-siRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,target_gene,string,1120,124,none | generic_low_risk | HSD17B13,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_state,categorical,1120,5,not_zilebesiran_or_AGT_context | zilebesiran_like_low_direct_hepatotoxici | RAAS_systemic_safety_monitoring_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_clinical_context,categorical,1120,2,not_applicable | hypertension_AGT_siRNA_RAAS_context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_target_gene,categorical,1120,2,not_applicable | AGT,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_target_mRNA,categorical,1120,2,not_applicable | angiotensinogen_mRNA,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_route,categorical,1120,2,not_applicable | subcutaneous,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_GalNAc_ASGPR_hepatocyte_delivery_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_clathrin_endocytosis_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_endosomal_depot_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_RISC_recycling_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_single_dose_mg_proxy,float,1120,7,0.0 | 300.0 | 600.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_dosing_interval_months_proxy,integer,1120,3,0.0 | 6.0 | 3.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_duration_of_PD_months_proxy,float,1120,24,0.0 | 6.2837 | 5.94321,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_serum_AGT_reduction_pct_proxy,float,1120,20,0.0 | 99.5 | 94.12331,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_systolic_BP_reduction_mmHg_proxy,float,1120,24,0.0 | 5.2747 | 10.45933,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_diastolic_BP_reduction_mmHg_proxy,float,1120,24,0.0 | 3.66768 | 3.50522,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_angII_reduction_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_aldosterone_reduction_context_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_hyperkalemia_pct_proxy,float,1120,24,0.0 | 3.13713 | 1.8146,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_hypotension_pct_proxy,float,1120,23,0.0 | 1.13129 | 3.02209,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_eGFR_decline_event_pct_proxy,float,1120,20,0.0 | 0.52718 | 2.75901,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_injection_site_reaction_pct_proxy,float,1120,24,0.0 | 0.57365 | 8.10577,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_immunogenicity_pct_proxy,float,1120,24,0.0 | 2.26563 | 3.12769,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_renal_function_monitoring_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_potassium_monitoring_flag,integer,1120,2,0 | 1,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_hypovolemia_rescue_context,categorical,1120,2,not_applicable | angiotensin_II_or_norepinephrine_or_flud,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_adherence_benefit_context_score,float,1120,10,0.0 | 0.98 | 0.95822,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_prolonged_PD_score,float,1120,10,0.0 | 0.98 | 0.94946,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_systemic_RAAS_safety_monitoring_score,float,1120,24,0.0 | 0.20613 | 0.21777,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_direct_hepatotoxicity_modifier,float,1120,24,0.0 | -0.14422 | -0.11156,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,zilebesiran_context_confidence_score,float,1120,24,0.0 | 0.83034 | 0.89445,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,context_note,categorical,1120,3,No zilebesiran/AGT RAAS context modeled  | Supporting GalNAc-siRNA AGT/RAAS platfor | Supporting AGT GalNAc-siRNA RAAS context,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,value_origin,categorical,1120,4,not_reported | inferred_from_paper | literature_grounded_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,record_origin,categorical,1120,1,dbbun_generated,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.
zilebesiran_raas_safety.csv,license_for_generated_output,categorical,1120,1,CC BY 4.0,Per-source evidence module: literature-grounded generation logic and design rationale contributed by a single source paper or context.