data_dictionary.csv

allowed_values_or_range,column_name,data_type,description,field_name,origin_rule,provenance,provenance_expectation,required,table_name,type,value_origin
,source_id,string_or_numeric,Unique source identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sources.csv,,
,title,string_or_numeric,Source paper or memo title.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sources.csv,,
,source_role,string_or_numeric,How the source contributes to generation logic.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sources.csv,,
,use_in_core_dataset,string_or_numeric,"Whether source is core, supporting, or governing.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sources.csv,,
,control_id,string_or_numeric,Unique control identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,controls.csv,,
,control_type,string_or_numeric,"Negative, positive, vehicle/mock, clinical reference, or stress-test control type.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,controls.csv,,
,control_rationale,string_or_numeric,Why this control is included.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,controls.csv,,
,expected_behavior,string_or_numeric,Expected synthetic readout behavior.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,controls.csv,,
,oligo_id,string_or_numeric,Unique generated oligonucleotide identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,oligos.csv,,
,sequence_5to3,string_or_numeric,Generated RNA sequence in 5 to 3 orientation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,oligos.csv,,
,oligo_modality,string_or_numeric,"ASO, gapmer, siRNA, GalNAc-siRNA, or related modality.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,oligos.csv,,
,control_id,string_or_numeric,"Control link, or NON_CONTROL_GENERATED_RECORD.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,oligos.csv,,
True | False,is_administered_oligo,boolean,"True if this row represents an administered oligonucleotide with an explicit sequence; False if this row represents a context-only record (e.g., vehicle/mock control, clinical risk-score reference, extracellular-vesicle delivery context, non-administered injury-model context).",,computed from sequence_length and oligo_modality,label carried where applicable,,yes,oligos.csv,,
,sugar_chemistry,string_or_numeric,Generated/inferred sugar chemistry class.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,chemical_modifications.csv,,
,phosphorothioate_fraction,string_or_numeric,Generated fraction of possible backbone linkages represented as PS.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,chemical_modifications.csv,,
,GalNAc_conjugated,string_or_numeric,"1 if GalNAc conjugation is present, else 0.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,chemical_modifications.csv,,
,purity,string_or_numeric,Generated or inferred oligo purity value.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,chemical_modifications.csv,,
,GC_content,string_or_numeric,Sequence GC fraction.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,biophysical_properties.csv,,
,seed_region_GC,string_or_numeric,GC fraction in seed-like region.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,biophysical_properties.csv,,
,predicted_offtarget_hybridization_burden,string_or_numeric,"Synthetic off-target burden score, 0-10.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,biophysical_properties.csv,,
,predicted_Tm_celsius,string_or_numeric,Generated melting temperature proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,biophysical_properties.csv,,
,predicted_delta_G_kcal_mol,string_or_numeric,Generated hybridization free energy proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,biophysical_properties.csv,,
,dose_nM,string_or_numeric,Generated or inferred concentration in nM.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,dose_exposure.csv,,
,dose_tier,string_or_numeric,Categorical dose tier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,dose_exposure.csv,,
,exposure_duration_days,string_or_numeric,Generated exposure duration.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,dose_exposure.csv,,
,relative_exposure_normalization,string_or_numeric,Dose normalized to 150 nM reference.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,dose_exposure.csv,,
,delivery_carrier_type,string_or_numeric,Generated delivery system or nanocarrier type.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
,delivery_carrier_class,string_or_numeric,"Lipid-based, polymeric, metallic/inorganic, biomimetic, direct conjugate, or none.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
,nanoparticle_size_nm,string_or_numeric,Generated particle size in nanometers; zero for direct conjugate or no carrier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
,zeta_potential_mV,string_or_numeric,Generated surface charge proxy in millivolts.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
,pegylated,string_or_numeric,1 if PEGylation or stealth-like coating is modeled.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
,targeting_ligand,string_or_numeric,"Generated active targeting ligand such as GalNAc, galactose, mannose, or none.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
,targeting_receptor,string_or_numeric,"Generated receptor context such as ASGPR, NTCP, mannose receptor, or none.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
,hepatic_targeting_score,string_or_numeric,Generated 0-1 liver-targeting score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
,kupffer_clearance_risk,string_or_numeric,Generated 0-1 Kupffer/RES clearance risk.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
,delivery_immunogenicity_score,string_or_numeric,Generated 0-1 delivery-related immunogenicity score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
,delivery_oxidative_stress_score,string_or_numeric,Generated 0-1 delivery-related oxidative stress score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,nanoparticle_delivery.csv,,
,rna_payload_type,string_or_numeric,"Generated RNA payload architecture such as single siRNA, single ASO, mRNA vaccine, or dual siRNA+mRNA.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
,siRNA_payload_fraction,string_or_numeric,Generated fraction of RNA payload represented as siRNA.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
,mRNA_payload_fraction,string_or_numeric,Generated fraction of RNA payload represented as mRNA.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
,pcsk9_knockdown_pct_proxy,string_or_numeric,Generated proxy for PCSK9 knockdown percentage when relevant.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
,MHC_I_upregulation_fold_proxy,string_or_numeric,Generated proxy for MHC-I upregulation fold-change when relevant.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
,antigen_presentation_fold_proxy,string_or_numeric,Generated proxy for antigen-presentation enhancement when relevant.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
,immune_activation_score,string_or_numeric,"Generated 0-1 immune-activation context score, separated from direct hepatotoxicity readouts.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
,inflammatory_context_score,string_or_numeric,Generated 0-1 inflammatory context score for stress-testing readout logic.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,rna_payload_systems.csv,,
,lipid_export_state,string_or_numeric,"Generated lipid-export context such as baseline, APOB-ASO inhibition, oleate challenge, heat-stress challenge, or combined lipid stress.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,lipid_homeostasis.csv,,
,mipomersen_like_APOB_ASO,string_or_numeric,Indicator that the row represents a Mipomersen-like APOB ASO context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,lipid_homeostasis.csv,,
,apob_inhibition_proxy,string_or_numeric,Generated proxy for APOB suppression; not a measured value.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,lipid_homeostasis.csv,,
,mttp_activity_suppression_proxy,string_or_numeric,Generated proxy for MTTP activity suppression in lipid-export context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,lipid_homeostasis.csv,,
,vldl_apob_secretion_proxy,string_or_numeric,Generated proxy for VLDL-ApoB secretion capacity.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,lipid_homeostasis.csv,,
,lipid_export_stress_score,string_or_numeric,Generated lipid-homeostasis stress score kept separate from direct hepatotoxicity evidence.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,lipid_homeostasis.csv,,
,epigenetic_liver_state,string_or_numeric,"Generated MASLD epigenetic/lipid state such as baseline, H3K27ac-high, SULT1B1-siRNA rescue, CEBPB-siRNA rescue, JQ1-like SE inhibition, or oleate-induced lipid accumulation.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,epigenetic_liver_context.csv,,
,h3k27ac_super_enhancer_activity_proxy,string_or_numeric,Generated proxy for H3K27ac/super-enhancer activity.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,epigenetic_liver_context.csv,,
,cebp_beta_activity_proxy,string_or_numeric,Generated proxy for C/EBPbeta activity.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,epigenetic_liver_context.csv,,
,sult1b1_expression_proxy,string_or_numeric,Generated proxy for SULT1B1 expression/activity.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,epigenetic_liver_context.csv,,
,hepatocyte_lipid_accumulation_proxy,string_or_numeric,Generated proxy for hepatocyte lipid accumulation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,epigenetic_liver_context.csv,,
,epigenetic_liver_stress_modifier,string_or_numeric,Generated modifier used to stress-test hepatotoxicity scoring under MASLD-like liver context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,epigenetic_liver_context.csv,,
,angptl3_platform_context,string_or_numeric,"Generated ANGPTL3 platform context: GalNAc-ASO/vupanorsen-like, GalNAc-siRNA/ARO-ANG3-like, mAb reference, or non-ANGPTL3.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,angptl3_liver_safety.csv,,
,angptl3_target_inhibition_pct_proxy,string_or_numeric,Generated proxy for ANGPTL3 target inhibition percentage.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,angptl3_liver_safety.csv,,
,angptl3_hepatic_fat_change_pct_proxy,string_or_numeric,Generated proxy for percent hepatic-fat change relative to baseline.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,angptl3_liver_safety.csv,,
,angptl3_alt_ast_gt3x_uln_probability_proxy,string_or_numeric,Generated probability proxy for ALT/AST greater than 3x ULN.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,angptl3_liver_safety.csv,,
,angptl3_transaminase_signal_fold_ULN_proxy,string_or_numeric,Generated transaminase signal proxy in fold upper limit of normal.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,angptl3_liver_safety.csv,,
,angptl3_liver_safety_stress_modifier,string_or_numeric,Generated stress modifier used to stress-test ANGPTL3 platform liver-safety context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,angptl3_liver_safety.csv,,
,pnpla3_genotype,string_or_numeric,"Generated PNPLA3 genotype context: wildtype, heterozygous, or I148M homozygous.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,pnpla3_precision_context.csv,,
,pnpla3_lipid_droplet_accumulation_proxy,string_or_numeric,Generated proxy for PNPLA3-associated lipid-droplet accumulation context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,pnpla3_precision_context.csv,,
,pnpla3_precision_therapy_modality,string_or_numeric,"Generated PNPLA3-targeted precision therapy context: none, siRNA, or ASO.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,pnpla3_precision_context.csv,,
,pnpla3_target_knockdown_pct_proxy,string_or_numeric,Generated proxy for PNPLA3 knockdown percentage.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,pnpla3_precision_context.csv,,
,pnpla3_hepatic_fat_reduction_pct_proxy,string_or_numeric,Generated proxy for hepatic-fat reduction under PNPLA3 silencing context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,pnpla3_precision_context.csv,,
,pnpla3_therapy_response_label,string_or_numeric,"Generated label describing homozygous response, heterozygous uncertainty, or baseline context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,pnpla3_precision_context.csv,,
,extrahepatic_delivery_state,string_or_numeric,"Generated extrahepatic delivery state, including cholesterol-conjugated siRNA muscle-delivery contexts.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
,extrahepatic_conjugate_type,string_or_numeric,"Generated conjugate type such as cholesterol conjugate, GalNAc conjugate, or none.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
,extrahepatic_administration_route,string_or_numeric,"Generated route such as intraperitoneal, intravenous, in vitro transfection, or gymnosis.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
,systemic_dose_mg_per_kg_proxy,string_or_numeric,Generated systemic dose proxy in mg/kg for animal delivery contexts.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
,skeletal_muscle_knockdown_pct_proxy,string_or_numeric,Generated proxy for skeletal-muscle target mRNA knockdown percentage.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
,diaphragm_knockdown_pct_proxy,string_or_numeric,Generated proxy for diaphragm knockdown percentage.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
,liver_knockdown_pct_proxy,string_or_numeric,"Generated proxy for liver target mRNA knockdown percentage, used as exposure/distribution context rather than injury evidence.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
,liver_marker_signal_fold_proxy,string_or_numeric,Generated liver-marker signal proxy; values near 1 imply no major signal.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
,extrahepatic_delivery_confidence_score,string_or_numeric,Generated confidence score for extrahepatic delivery/distribution context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,extrahepatic_delivery.csv,,
,personalized_aso_state,string_or_numeric,"Generated patient-customized ASO workflow state, such as design, fibroblast screen, intrathecal dosing, toxicology, or N-of-1 monitoring.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
,customized_to_patient_variant,string_or_numeric,1 when the record is modeled as patient-specific variant-informed ASO design context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
,splice_modulating_strategy,string_or_numeric,Generated splice-modulation strategy such as cryptic splice acceptor blocking.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
,aso_backbone_chemistry,string_or_numeric,"Generated ASO backbone chemistry context, e.g., phosphorothioate.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
,aso_sugar_chemistry,string_or_numeric,"Generated sugar chemistry context, e.g., 2prime-MOE.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
,sequence_specific_offtarget_screen_pass,string_or_numeric,Generated binary proxy indicating whether the sequence passed a basic off-target screen.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
,fibroblast_splice_rescue_fold_proxy,string_or_numeric,Generated proxy for in vitro splice rescue fold change.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
,rat_toxicology_dose_multiple_proxy,string_or_numeric,Generated preclinical toxicology dose multiple context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
,human_dose_mg_proxy,string_or_numeric,"Generated human intrathecal dose context in mg, when applicable.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
,csf_trough_ng_per_ml_proxy,string_or_numeric,Generated CSF trough concentration context for intrathecal dosing records.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
,personalized_workflow_confidence_score,string_or_numeric,Generated confidence score for the ASO workflow context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,personalized_aso_workflow.csv,,
,aso_metabolic_nafld_state,string_or_numeric,"Generated ASO metabolic/NAFLD context such as GalNAc-targeted benefit, native ASO broad distribution, lipid/DNL target ASO, sequence-motif toxicity, type-I IFN response, or kidney monitoring context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_metabolic_target_class,string_or_numeric,"Generated target class such as DNL/lipid partitioning, immune/adipose context, or general ASO metabolic context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_RNase_H1_gapmer_context,string_or_numeric,1 when an RNase-H1/gapmer-like ASO mechanism is modeled.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_GalNAc_hepatocyte_targeting_multiplier_proxy,string_or_numeric,Generated GalNAc hepatocyte-targeting potency multiplier proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_predicted_steatosis_change_proxy,string_or_numeric,Generated proxy for steatosis change; negative values indicate modeled improvement.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_insulin_sensitivity_improvement_proxy,string_or_numeric,Generated proxy for insulin-sensitivity improvement under metabolic ASO contexts.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_DNL_pathway_suppression_proxy,string_or_numeric,Generated proxy for de novo lipogenesis or lipid-partitioning pathway suppression.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_metabolic_benefit_score,string_or_numeric,Generated 0-1 metabolic benefit score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_hepatic_injury_challenge_score,string_or_numeric,Generated 0-1 hepatic injury/safety-challenge score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_ALT_AST_monitoring_fold_proxy,string_or_numeric,Generated ALT/AST monitoring fold-change proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_GGT_monitoring_fold_proxy,string_or_numeric,Generated GGT monitoring fold-change proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_sequence_motif_toxicity_context,string_or_numeric,"Generated sequence-motif toxicity context, including TGC/TCC-like motif flags when relevant.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_type_I_interferon_response_proxy,string_or_numeric,Generated type-I-interferon off-target response proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_kidney_injury_monitoring_proxy,string_or_numeric,Generated kidney-injury monitoring proxy for ASO safety context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,aso_metabolic_safety_label,string_or_numeric,Generated label summarizing ASO metabolic benefit versus safety challenge.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,aso_metabolic_nafld_context.csv,,
,assay_id,string_or_numeric,Unique generated assay identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,assays.csv,,
,cell_model,string_or_numeric,Liver-relevant model system.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,assays.csv,,
,human_in_vitro_or_clinical_proxy,string_or_numeric,1 for human-relevant in vitro or clinical proxy models.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,assays.csv,,
,time_hours,string_or_numeric,Assay readout timepoint.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,assays.csv,,
,viability_pct,string_or_numeric,Generated viability percentage.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
,ALT_AST_proxy_fold_change,string_or_numeric,Generated ALT/AST-like liver injury proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
,apoptosis_score,string_or_numeric,Generated apoptosis score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
,stress_response_score,string_or_numeric,Generated stress signaling score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
,transcriptomic_perturbation_score,string_or_numeric,Generated transcriptomic perturbation score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
,immune_activation_score,string_or_numeric,"Generated immune-activation context score, separated from direct hepatotoxicity measurement.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
,inflammatory_context_score,string_or_numeric,Generated inflammatory-context score used to stress-test readout generation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
,overall_hepatotoxicity_risk_score,string_or_numeric,"Composite time-adjusted synthetic risk score, 0-10.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
,hepatotoxicity_label,string_or_numeric,"low, moderate, or high.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,toxicity_readouts.csv,,
,generated_record_id,string_or_numeric,Unified generated record identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,generated_records.csv,,
,record_type,string_or_numeric,oligo_level_record or toxicity_readout_record.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,generated_records.csv,,
,measured_experimental_value,string_or_numeric,Always no unless later manually upgraded.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,generated_records.csv,,
,assumption_id,string_or_numeric,Unique assumption identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,assumptions.csv,,
,assumption_text,string_or_numeric,Human-readable assumption statement.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,assumptions.csv,,
,provenance_id,string_or_numeric,Unique provenance row identifier.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,provenance.csv,,
,source_pdf_redistributed,string_or_numeric,No; source PDFs are not included in generated output.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,provenance.csv,,
,sequence_modification_toxicity_state,string_or_numeric,"Generated sequence/modification toxicity state, including LNA/PS gapmer low-risk, high-risk, redesign, or applicability-domain context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,lna_gapmer_context,string_or_numeric,1 when the record is modeled as an LNA/gapmer-style sequence-toxicity context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,phosphorothioate_full_backbone_context,string_or_numeric,1 when high/full PS-backbone context is modeled.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,dinucleotide_feature_encoding,string_or_numeric,"Generated descriptor of the sequence encoding concept, such as 64-dinucleotide count vector context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,toxic_gap_motif_count_proxy,string_or_numeric,Generated count of higher-risk motif proxies in the DNA-like sequence representation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,protective_or_lower_risk_motif_count_proxy,string_or_numeric,Generated count of lower-risk/protective motif proxies in the DNA-like sequence representation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,model_family,string_or_numeric,"Generated model-family label, such as random-forest-style dinucleotide classifier context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,training_set_oligo_count_proxy,string_or_numeric,Source-informed training-set size proxy used for context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,oob_accuracy_proxy,string_or_numeric,Source-informed out-of-bag accuracy proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,validation_accuracy_proxy,string_or_numeric,Source-informed independent validation accuracy proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,predicted_sequence_hepatotoxicity_probability_proxy,string_or_numeric,Generated probability-like proxy for sequence/modification hepatotoxicity potential.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,predicted_ALT_fold_from_sequence_model_proxy,string_or_numeric,Generated ALT fold proxy derived from sequence/modification risk context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,predicted_sequence_toxicity_class,string_or_numeric,Generated low/high/not-modeled sequence-toxicity class.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,nearest_training_edit_distance_proxy,string_or_numeric,Generated edit-distance/applicability-domain proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,prediction_confidence_by_distance_label,string_or_numeric,Generated confidence label based on near/medium/far distance context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,redesign_to_lower_toxicity_applicable,string_or_numeric,1 when a sequence redesign-to-lower-toxicity concept is applicable.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,sequence_redesign_risk_reduction_proxy,string_or_numeric,Generated risk-reduction proxy for redesigned sequence context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,sequence_modification_toxicity_modifier,string_or_numeric,Generated risk-score modifier from sequence/modification toxicity profile.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sequence_modification_toxicity.csv,,
,hsd17b13_clinical_state,string_or_numeric,Generated HSD17B13/rapirosiran clinical context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
,rapirosiran_like_dose_mg_proxy,string_or_numeric,Generated rapirosiran-like clinical dose proxy in mg.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
,rapirosiran_HSD17B13_mRNA_change_month6_pct_proxy,string_or_numeric,Generated percentage-change proxy for liver HSD17B13 mRNA at Month 6.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
,rapirosiran_ALT_change_day169_pct_proxy,string_or_numeric,Generated ALT percentage-change proxy around Day 169/Month 6 clinical context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
,rapirosiran_AST_change_day169_pct_proxy,string_or_numeric,Generated AST percentage-change proxy around Day 169/Month 6 clinical context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
,rapirosiran_no_DILI_observed_flag,string_or_numeric,Generated flag representing no drug-induced liver injury context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
,rapirosiran_ASGPR_saturation_context,string_or_numeric,Generated ASGPR/GalNAc uptake and transient saturation context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
,rapirosiran_clinical_safety_modifier,string_or_numeric,Generated risk-score safety modifier from rapirosiran clinical context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
,rapirosiran_clinical_benefit_modifier,string_or_numeric,Generated benefit/PD modifier from HSD17B13 knockdown and clinical context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hsd17b13_rapirosiran_clinical_pd.csv,,
,hbv_rnai_state,string_or_numeric,Generated VIR-2218/ALN-HBV ESC+ HBV RNAi context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
,hbv_rnai_ESCplus_seed_modification,string_or_numeric,Generated flag for ESC+ seed-region modification context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
,hbv_rnai_gna_seed_substitution,string_or_numeric,Generated flag for glycol nucleic acid seed-region substitution context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
,hbv_rnai_seed_mediated_offtarget_reduction_score,string_or_numeric,Generated score representing reduced seed-mediated off-target binding context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
,hbv_rnai_predicted_offtarget_gene_dysregulation_score,string_or_numeric,Generated off-target gene-dysregulation proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
,hbv_rnai_healthy_volunteer_ALT_elevation_pct_proxy,string_or_numeric,Generated percentage proxy for healthy-volunteer ALT-elevation context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
,hbv_rnai_highest_ALT_xULN_proxy,string_or_numeric,Generated highest ALT relative to upper limit of normal proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
,hbv_rnai_HBsAg_reduction_week20_log10_proxy,string_or_numeric,Generated Week-20 HBsAg log10 reduction proxy for cHBV context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
,hbv_rnai_HBsAg_reduction_week48_log10_proxy,string_or_numeric,Generated Week-48 HBsAg log10 reduction proxy for cHBV context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
,hbv_rnai_safety_modifier,string_or_numeric,Generated modifier linking seed/off-target/ALT context to synthetic hepatotoxicity score.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
,hbv_rnai_antiviral_activity_score,string_or_numeric,Generated antiviral PD context score based on HBsAg reduction proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,hbv_rnai_escplus_safety.csv,,
,zilebesiran_state,string_or_numeric,Generated zilebesiran/AGT GalNAc-siRNA RAAS context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
,zilebesiran_target_mRNA,string_or_numeric,Target mRNA context for angiotensinogen/AGT silencing.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
,zilebesiran_GalNAc_ASGPR_hepatocyte_delivery_flag,string_or_numeric,Flag for GalNAc-ASGPR hepatocyte-targeted delivery context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
,zilebesiran_endosomal_depot_context_flag,string_or_numeric,Flag for prolonged endosomal-depot context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
,zilebesiran_RISC_recycling_context_flag,string_or_numeric,Flag for RISC-recycling and repeated target mRNA degradation context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
,zilebesiran_single_dose_mg_proxy,string_or_numeric,Generated fixed-dose mg proxy for zilebesiran-like clinical context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
,zilebesiran_serum_AGT_reduction_pct_proxy,string_or_numeric,Generated serum angiotensinogen reduction percentage proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
,zilebesiran_systolic_BP_reduction_mmHg_proxy,string_or_numeric,Generated systolic blood-pressure reduction proxy in mmHg.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
,zilebesiran_hyperkalemia_pct_proxy,string_or_numeric,Generated hyperkalemia event percentage proxy for systemic RAAS safety monitoring.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
,zilebesiran_hypotension_pct_proxy,string_or_numeric,Generated hypotension event percentage proxy for systemic RAAS safety monitoring.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
,zilebesiran_eGFR_decline_event_pct_proxy,string_or_numeric,Generated eGFR-decline/renal-function monitoring event proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
,zilebesiran_hypovolemia_rescue_context,string_or_numeric,Generated context label for reversibility/rescue strategies when RAAS is suppressed.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
,zilebesiran_direct_hepatotoxicity_modifier,string_or_numeric,Generated modifier showing that this source contributes little direct hepatotoxicity signal while tracking systemic safety separately.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,zilebesiran_raas_safety.csv,,
,sirna_bulge_state,string_or_numeric,Generated siRNA bulge-context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
,guide_strand_bulge_mode,string_or_numeric,Guide-passenger or guide-target/degenerate target bulge mode.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
,bulge_length_nt_proxy,string_or_numeric,Generated bulge length proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
,bulge_position_guide_nt_proxy,string_or_numeric,Generated guide-strand position proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
,bulge_region_label,string_or_numeric,"Seed, central, terminal, or reference region label.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
,offtarget_prediction_include_deletions_flag,string_or_numeric,Flag indicating off-target prediction should consider nucleotide omissions/deletions that create tolerated bulges.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
,bulge_related_offtarget_risk_modifier,string_or_numeric,Generated off-target-risk modifier from tolerated/degenerated bulge context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,sirna_bulge_offtarget_tolerance.csv,,
,fbll1_hcc_state,string_or_numeric,Generated FBLL1/HCC spatial-oncogenic context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
,fbll1_malignant_hepatocyte_enrichment_score,string_or_numeric,Generated proxy for FBLL1 enrichment in malignant hepatocytes / tumor regions.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
,fbll1_siRNA_knockdown_context_flag,string_or_numeric,Flag for FBLL1 siRNA knockdown functional experiment context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
,fbll1_knockdown_proliferation_suppression_proxy,string_or_numeric,Generated proxy for proliferation suppression after FBLL1 knockdown.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
,fbll1_overexpression_tumorigenesis_proxy,string_or_numeric,Generated proxy for tumorigenesis/colony/migration context after FBLL1 overexpression.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
,fbll1_EGFR_MAPK_activation_score_proxy,string_or_numeric,Generated proxy for c-Myc/EGFR-ligand/MAPK activation context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
,fbll1_direct_oligotox_relevance_modifier,string_or_numeric,Small modifier clarifying that this source is mostly HCC/RNAi functional context rather than direct oligonucleotide hepatotoxicity evidence.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,fbll1_hcc_spatial_oncogenic_context.csv,,
,galnac_lnp_mkk4_state,string_or_numeric,Generated GalNAc-LNP-siMKK4 hepatocyte-targeted liver-regeneration context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
,mkk4_lnp_dual_targeting_context,string_or_numeric,LNP liver tropism plus GalNAc/ASGPR hepatocyte active-targeting context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
,mkk4_lnp_target_selectivity_mkk7_avoidance_score,string_or_numeric,Generated proxy for MKK4-selective siRNA design relative to MKK7 off-target concern.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
,mkk4_lnp_particle_size_nm_proxy,string_or_numeric,Generated particle-size proxy based on GalNAc-LNP-siMKK4 characterization.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
,mkk4_lnp_encapsulation_efficiency_pct_proxy,string_or_numeric,Generated encapsulation-efficiency proxy for GalNAc-LNP-siMKK4.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
,mkk4_lnp_hepatocyte_targeting_score,string_or_numeric,Generated ASGPR/HNF-4a hepatocyte-targeting proxy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
,mkk4_lnp_mkk4_knockdown_score,string_or_numeric,Generated proxy for MKK4 silencing strength.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
,mkk4_lnp_liver_regeneration_score_proxy,string_or_numeric,Generated proxy for liver-regeneration/proliferation rescue.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
,mkk4_lnp_direct_hepatotoxicity_modifier,string_or_numeric,Modifier separating background injury model from direct oligo/LNP hepatotoxicity.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_lnp_mkk4_liver_regeneration.csv,,
,ogt_sev_lsec_state,string_or_numeric,"Generated state for OGT-enriched hepatocyte-derived sEV, LSEC capillarization, OGT knockdown, BAGN rescue, or healthy-sEV reference context.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
,ogt_sev_ogt_cargo_score_proxy,string_or_numeric,Generated proxy for OGT cargo enrichment in hepatocyte-derived or serum sEVs.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
,ogt_sev_HNF1A_ser471_OGlcNAcylation_score_proxy,string_or_numeric,Generated proxy for HNF1A Ser471 O-GlcNAcylation linked to Ang-2 transcriptional activation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
,ogt_sev_Ang2_transcription_activation_score_proxy,string_or_numeric,Generated proxy for Ang-2 transcription/expression activation downstream of HNF1A.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
,ogt_sev_LSEC_capillarization_score_proxy,string_or_numeric,Generated proxy for LSEC capillarization/angiogenesis/defenestration context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
,ogt_sev_ALT_AST_correlation_context_score_proxy,string_or_numeric,Generated proxy for MASLD serum ALT/AST association with OGT/sEV context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
,ogt_sev_BAGN_rescue_score_proxy,string_or_numeric,Generated proxy for BAGN-mediated O-GlcNAc inhibition and MASLD/LSEC rescue.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
,ogt_sev_masld_progression_modifier,string_or_numeric,Modifier representing MASLD microenvironment stress from OGT/sEV/LSEC capillarization context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
,ogt_sev_direct_oligotox_relevance_modifier,string_or_numeric,Small modifier indicating indirect relevance to OligoTox liver context; not direct oligo toxicity evidence.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,ogt_sev_lsec_masld_context.csv,,
,malat1_hbv_hcc_state,string_or_numeric,"Generated state for HBx-induced MALAT1, m6A/IGF2BP3 shuttling, ASO-MALAT1 rescue, HBV replication context, or non-modeled reference.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
,malat1_expression_score_proxy,string_or_numeric,Generated proxy for MALAT1 expression in HBV/HBx-related HCC context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
,malat1_m6a_score_proxy,string_or_numeric,Generated proxy for MALAT1 m6A modification level.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
,malat1_mettl3_mettl14_wtap_recruitment_score_proxy,string_or_numeric,Generated proxy for MALAT1 recruitment of m6A writer complex METTL3/METTL14/WTAP.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
,malat1_m6a_site_6021A_score_proxy,string_or_numeric,Generated proxy for contribution of MALAT1 6021A m6A site.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
,malat1_m6a_site_7265A_score_proxy,string_or_numeric,Generated proxy for contribution of MALAT1 7265A m6A site.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
,malat1_igf2bp3_binding_score_proxy,string_or_numeric,Generated proxy for m6A-dependent MALAT1 binding by IGF2BP3.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
,malat1_cytoplasmic_export_score_proxy,string_or_numeric,Generated proxy for IGF2BP3-associated MALAT1 nuclear-cytoplasmic shuttling.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
,malat1_aso_tumor_suppression_score_proxy,string_or_numeric,Generated proxy for ASO-MALAT1 suppression of HBV-related HCC tumor growth/spread.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
,malat1_hbv_pgRNA_reduction_proxy,string_or_numeric,Generated proxy for reduction in HBV pgRNA context following ASO-MALAT1 treatment.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
,malat1_hepatocarcinogenesis_context_modifier,string_or_numeric,Modifier representing HBV/HBx/MALAT1 liver-cancer context severity.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
,malat1_direct_oligotox_relevance_modifier,string_or_numeric,Small modifier indicating indirect relevance to OligoTox through ASO liver intervention and liver disease context; not direct oligo toxicity evidence.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,malat1_hbv_hcc_aso_context.csv,,
,cd133_masld_hcc_state,string_or_numeric,"Generated state for CD133-positive MASLD-HCC cancer stem cell enrichment, MYH9/beta-catenin mechanism, multikinase-inhibitor resistance, or VNP-siCD133 rescue.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
,cd133_csc_enrichment_score_proxy,string_or_numeric,Generated proxy for enrichment of CD133-positive cancer stem cell context in MASLD-HCC.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
,cd133_lineage_expansion_score_proxy,string_or_numeric,Generated proxy for CD133 lineage expansion/clonal amplification context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
,cd133_self_renewal_score_proxy,string_or_numeric,Generated proxy for organoid/self-renewal stemness context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
,cd133_tumor_initiating_capacity_proxy,string_or_numeric,Generated proxy for tumor-initiating capacity in MASLD-HCC models.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
,cd133_mki_resistance_score_proxy,string_or_numeric,Generated proxy for resistance to multikinase inhibitors such as sorafenib or lenvatinib.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
,cd133_myh9_interaction_score_proxy,string_or_numeric,Generated proxy for CD133-MYH9 physical/mechanistic interaction context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
,cd133_wnt_bcat_activation_score_proxy,string_or_numeric,Generated proxy for Wnt/active-beta-catenin pathway activation.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
,cd133_vnp_sicd133_delivery_context_flag,string_or_numeric,Flag indicating VNP-siCD133 nanoparticle delivery context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
,cd133_2prime_ome_pyrimidine_modification_flag,string_or_numeric,Flag indicating stabilizing 2-prime-O-methyl pyrimidine-modified siRNA context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
,cd133_tumor_weight_reduction_score_proxy,string_or_numeric,Generated proxy for tumor-weight/burden reduction after VNP-siCD133 plus multikinase inhibitor context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
,cd133_masld_hcc_therapeutic_rescue_score_proxy,string_or_numeric,Composite generated proxy for therapeutic rescue after CD133-targeted siRNA combination therapy.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
,cd133_direct_oligotox_relevance_modifier,string_or_numeric,Small modifier indicating indirect relevance to OligoTox through siRNA liver intervention and liver-disease context; not direct oligo toxicity evidence.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,cd133_masld_hcc_sirna_context.csv,,
,galnac_rbc_ev_state,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
,rbc_ev_asgpr_hepatocyte_uptake_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
,rbc_ev_payload_type,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
,rbc_ev_mir155_knockdown_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
,rbc_ev_rab7_knockdown_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
,rbc_ev_parp1_par_reduction_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
,rbc_ev_alf_alt_ast_reduction_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
,rbc_ev_panoptosis_reduction_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
,rbc_ev_nafld_steatosis_reduction_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
,rbc_ev_hcc_tumor_suppression_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
,rbc_ev_vital_organ_toxicity_score_proxy,string_or_numeric,GalNAc-RBC-EV hepatocyte delivery / liver disease context field from Huang et al. 2025 module.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,galnac_rbc_ev_liver_delivery.csv,,
,meldplus_cirrhosis_state,string_or_numeric,Generated MELD-Plus/cirrhosis clinical risk context state.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
,meldplus_variable_count_proxy,string_or_numeric,Number of structured clinical variables represented in the MELD-Plus model context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
,meldplus_albumin_g_dl_proxy,string_or_numeric,Generated proxy for albumin value used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
,meldplus_total_bilirubin_mg_dl_proxy,string_or_numeric,Generated proxy for total bilirubin value used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
,meldplus_creatinine_mg_dl_proxy,string_or_numeric,Generated proxy for creatinine value used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
,meldplus_inr_proxy,string_or_numeric,Generated proxy for INR value used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
,meldplus_sodium_mmol_l_proxy,string_or_numeric,Generated proxy for sodium value used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
,meldplus_wbc_th_cumm_proxy,string_or_numeric,Generated proxy for white blood cell count used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
,meldplus_total_cholesterol_mg_dl_proxy,string_or_numeric,Generated proxy for total cholesterol used in MELD-Plus context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
,meldplus_predicted_90day_mortality_probability_proxy,string_or_numeric,Generated proxy for MELD-Plus-like 90-day post-discharge mortality probability.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
,meldplus_auroc_mgh_bwh_90day_proxy,string_or_numeric,Paper-reported AUROC context for MGH/BWH 90-day MELD-Plus model.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
,meldplus_auroc_external_validation_proxy,string_or_numeric,Paper-reported AUROC context for external validation cohort.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
,meldplus_clinical_severity_modifier,string_or_numeric,Generated clinical liver-severity modifier used to connect hepatotoxicity outputs to cirrhosis outcome-risk context.,,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
,meldplus_direct_oligotox_relevance_modifier,string_or_numeric,"Small modifier indicating indirect clinical liver-risk relevance, not direct oligo intrinsic toxicity evidence.",,reported/extracted/inferred/generated/not_reported label carried where applicable,,,yes,meldplus_cirrhosis_risk_context.csv,,
0 or 1,,integer_flag,Flag indicating source is supporting preprint context rather than definitive peer-reviewed OligoTox evidence.,preprint_caution_flag,,,source_metadata,yes,ago1_lnp_aso_endothelial_liver_vascular_context.csv,,
0 to 1,,float,Generated proxy score summarizing ALT/AST safety-monitoring context for LNP-AGO1-ASO-like records.,ALT_AST_safety_monitoring_score_proxy,,,literature_grounded_generated,yes,ago1_lnp_aso_endothelial_liver_vascular_context.csv,,
0 to 1,,float,Generated proxy score for delivery and translational relevance of LNP-ASO context.,delivery_translatability_score_proxy,,,literature_grounded_generated,yes,ago1_lnp_aso_endothelial_liver_vascular_context.csv,,
controlled generated categories,,string,"Generated state label for GYS1 ASO Pompe substrate-reduction, combination therapy, tolerability, or specificity context.",gys1_pompe_state,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
2prime_constrained_ethyl_cEt,,string,Sugar modification context for the systemic GYS1 ASO module.,aso_sugar_modification,,,source_metadata,yes,gys1_pompe_aso_srt_context.csv,,
3_10_3_cEt_gapmer,,string,Gapmer architecture used to represent the source ASO design.,gapmer_architecture,,,source_metadata,yes,gys1_pompe_aso_srt_context.csv,,
0 to 1,,float,Generated proxy for Gys1 mRNA knockdown fraction in muscle-context records.,Gys1_mRNA_knockdown_fraction_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
0 to 1,,float,Generated proxy for specificity of GYS1 targeting versus liver GYS2 sparing.,GYS1_GYS2_isoform_specificity_score_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
0 to 1,,float,Generated proxy for muscle glycogen reduction fraction in the Pompe ASO substrate-reduction context.,quadriceps_glycogen_reduction_fraction_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
positive,,float,Generated proxy for ALT fold-change safety monitoring in systemic ASO treatment context.,ALT_fold_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
positive,,float,Generated proxy for AST fold-change safety monitoring in systemic ASO treatment context.,AST_fold_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
positive,,float,Generated proxy for kidney/safety chemistry monitoring context.,BUN_fold_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
positive,,float,Generated proxy for muscle injury/safety chemistry monitoring context.,CK_fold_proxy,,,literature_grounded_generated,yes,gys1_pompe_aso_srt_context.csv,,
0 or 1,,integer_flag,Flag indicating source is supporting preprint context rather than definitive peer-reviewed OligoTox evidence.,preprint_caution_flag,,,source_metadata,yes,gys1_pompe_aso_srt_context.csv,,
controlled generated categories,,string,"Generated state label for DDC cholestasis, recovery/resolution, CX3CL1-CX3CR1 macrophage recruitment, or NFYA/TGFB1 fibrosis context.",cholestasis_state,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
positive,,float,Generated ALT fold-change proxy for cholestatic hepatobiliary injury context.,ALT_fold_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
positive,,float,Generated alkaline phosphatase fold-change proxy for cholestatic injury context.,ALP_fold_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
positive,,float,Generated bilirubin fold-change proxy for cholestasis context.,bilirubin_fold_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
positive,,float,Generated proxy for cholangiocyte CX3CL1 expression fold-change.,CX3CL1_expression_fold_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
0 to 1,,float,Generated score for periportal CX3CR1-positive macrophage recruitment context.,CX3CR1_macrophage_recruitment_score_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
0 to 1,,float,Generated score for pathogen-induced cytokine storm signaling pathway activation in cholangiocytes.,PICSS_pathway_activation_score_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
0 to 1,,float,Generated score for NF-YA nuclear activation in cholangiocytes.,NFYA_nuclear_activation_score_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
0 to 1,,float,Generated score for cholangiocyte TGFβ1 expression/fibrogenic signaling context.,TGFB1_expression_score_proxy,,,literature_grounded_generated,yes,cholangiocyte_cholestasis_recovery_context.csv,,
0 or 1,,integer_flag,Flag for mechanistic siRNA NF-YA suppression reducing TGFβ1 expression in human cholangiocytes.,siRNA_NFYA_TGFB1_reduction_context_flag,,,source_metadata,yes,cholangiocyte_cholestasis_recovery_context.csv,,
controlled generated categories,,string,"Generated state label for PCDHA11 AmNA-ASO target-specificity, off-target-screening, or sequence-dependent reversible liver-injury context.",pcdha11_amna_state,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
0 or 1,,integer_flag,Flag indicating generated AmNA-modified flanking nucleotide ASO context.,AmNA_modified_flanking_nucleotide_flag,,,source_metadata,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
0 or 1,,integer_flag,Flag indicating generated fully phosphorothioated ASO backbone context.,all_phosphate_groups_phosphorothioated_flag,,,source_metadata,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
"0.2, 0.6, 2.0 or generated nearby values",,float,"Generated mouse intraperitoneal dose proxy corresponding to the 0.2, 0.6, or 2.0 mg study structure.",mouse_intraperitoneal_dose_mg_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
positive,,float,Generated peak AST fold-change proxy for AmNA-ASO liver-enzyme response.,AST_peak_fold_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
positive,,float,Generated peak ALT fold-change proxy for AmNA-ASO liver-enzyme response.,ALT_peak_fold_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
positive,,float,Generated peak ALP fold-change proxy for AmNA-ASO liver-enzyme/cholestatic response.,ALP_peak_fold_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
0 to 1,,float,Generated score for recovery of liver-enzyme signals after treatment cessation.,recovery_after_treatment_cessation_score_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
0 to 1,,float,Generated score representing sequence-dependent liver-injury liability among PCDHA11 ASO candidates.,sequence_dependent_liver_injury_score_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
non-negative,,integer,Generated mismatch/off-target burden proxy based on the source paper's in silico and microarray screening structure.,offtarget_mismatch_burden_proxy,,,literature_grounded_generated,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
0 or 1,,integer_flag,Flag for target-specificity context comparing parental PCDHA11-expressing cells with PCDHA11-knockout cells.,PCDHA11_knockout_specificity_context_flag,,,source_metadata,yes,pcdha11_amna_aso_hepatotoxicity.csv,,
0 to 1,,float,Generated score for PS-ASO nuclear PS-body/condensate formation under DNA-damage-response toxicity context.,PS_body_formation_score_proxy,,,,yes,ps_aso_dna_damage_response.csv,,literature_grounded_generated
0 to 1,,float,Generated score for ASO-associated DNA-PKcs binding/activation proxy.,DNA_PKcs_binding_activation_score_proxy,,,,yes,ps_aso_dna_damage_response.csv,,literature_grounded_generated
0 to 1,,float,Generated score for ASO-associated ATM binding/activation proxy.,ATM_binding_activation_score_proxy,,,,yes,ps_aso_dna_damage_response.csv,,literature_grounded_generated
0 to 1,,float,Generated score for ASO-associated PARP1 binding/PARylation proxy.,PARP1_binding_PARylation_score_proxy,,,,yes,ps_aso_dna_damage_response.csv,,literature_grounded_generated
0 to 1,,float,Composite generated proxy for PS-ASO DNA-damage-response toxicity mechanism.,overall_ASO_DDR_toxicity_mechanism_score_proxy,,,,yes,ps_aso_dna_damage_response.csv,,literature_grounded_generated
0 to 1,,float,Generated score for oxidative-stress responsive nanocarrier shell disassembly in MASH context.,ROS_triggered_shell_disassembly_score_proxy,,,,yes,sirubicon_ros_galnac_mash_delivery.csv,,literature_grounded_generated
0 to 1,,float,Generated score for GalNAc/ASGPR hepatocyte uptake context.,ASGPR_hepatocyte_uptake_score_proxy,,,,yes,sirubicon_ros_galnac_mash_delivery.csv,,literature_grounded_generated
0 to 1,,float,Generated Rubicon knockdown score proxy for siRubicon records.,Rubicon_knockdown_score_proxy,,,,yes,sirubicon_ros_galnac_mash_delivery.csv,,literature_grounded_generated
positive,,float,"Generated ALT proxy relative to MASH control context, where lower values indicate improved liver-function context.",ALT_relative_to_MASH_control_proxy,,,,yes,sirubicon_ros_galnac_mash_delivery.csv,,literature_grounded_generated
0 to 1,,float,Composite generated proxy balancing delivery/lipophagy benefit against nanocarrier safety risk.,overall_delivery_benefit_minus_safety_risk_score_proxy,,,,yes,sirubicon_ros_galnac_mash_delivery.csv,,literature_grounded_generated
0 to 1,,float,"Composite generated score balancing ASO knockdown, nuclease stability, and ALT/AST toxicity proxies.",activity_safety_window_score_proxy,,,,yes,scpBNA2_aso_chemistry_safety.csv,,literature_grounded_generated
0 to 1,,float,Composite generated score for APAP liver-injury rescue context.,overall_APAP_AILI_rescue_score_proxy,,,,yes,siCyp2e1_lnp_apap_aili.csv,,literature_grounded_generated
0 to 1,,float,Generated index balancing hepatocyte association against nonparenchymal-cell association.,hepatocyte_selectivity_index_proxy,,,,yes,lipid_nanp_liver_cell_targeting.csv,,literature_grounded_generated
see table,,string_or_numeric,Generated score representing monitoring of non-target/off-target toxicity and dose-window evidence for self-assembling RNA nanoparticles.,offtarget_toxicity_monitoring_score_proxy,,,,yes,rna_nanoparticle_hcc_multitarget.csv,,literature_grounded_generated
see table,,string_or_numeric,Generated score representing no-visible-toxicity/tolerability context for DCA-conjugated asymmetric siRNA.,visible_toxicity_absence_score_proxy,,,,yes,myc_asirna_dca_design_safety.csv,,literature_grounded_generated
see table,,string_or_numeric,Generated score representing ligand/peptide-enabled intracellular delivery context for multifunctional HDOs.,intracellular_delivery_score_proxy,,,,yes,multifunctional_hdo_delivery.csv,,literature_grounded_generated
see table,,string_or_numeric,Official Phase 2 judging criterion represented by dataset components.,judging_criterion,,,,yes,challenge_alignment_scorecard.csv,,literature_grounded_generated
see table,,string_or_numeric,Public-domain information gap addressed by a source/module.,gap_addressed,,,,yes,information_gap_map.csv,,literature_grounded_generated
see table,,string_or_numeric,Field/table role for predictive modeling or validation.,modeling_role,,,,yes,model_readiness_report.csv,,literature_grounded_generated
see table,,string_or_numeric,"Decision to include, support, defer, or exclude a source.",triage_decision,,,,yes,source_triage_log.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,"Generated candidate class: screened, potent safe, toxicity-signal, or benchmark comparator.",candidate_class,,,,no,agt_galnac_sirna_development_toxicology.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated RNAseq-style dose-dependent downregulated gene count proxy used as an off-target/toxicity indicator.,rnaseq_dose_dependent_downregulated_gene_count_proxy,,,,no,agt_galnac_sirna_development_toxicology.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated safety-class label derived from ALT/AST/urea/histopathology/off-target proxies.,safety_class_generated,,,,no,agt_galnac_sirna_development_toxicology.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated IRG1/ACOD1 expression proxy after CpG ODN/APAP/macrophage scenario simulation.,acod1_irg1_expression_score_proxy,,,,no,cpg_odn_apap_macrophage_immunomodulation.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated itaconate pathway proxy linked to macrophage protection and oxidative-stress mitigation.,itaconate_metabolite_score_proxy,,,,no,cpg_odn_apap_macrophage_immunomodulation.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated survival/improvement score for APAP injury scenarios.,survival_improvement_score_proxy,,,,no,cpg_odn_apap_macrophage_immunomodulation.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated PET/PK organ Cmax proxy expressed as percent injected dose per gram.,cmax_percent_injected_dose_per_g_proxy,,,,no,erbb2_aptamer_pet_pk.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated PET/PK AUC proxy for organ/tissue exposure across the dynamic acquisition window.,auc_0_5400_proxy,,,,no,erbb2_aptamer_pet_pk.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Flag for organs relevant to renal/hepatobiliary exposure and oligo ADME context.,hepatobiliary_or_renal_burden_flag,,,,no,erbb2_aptamer_pet_pk.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated score for ASO/PNA BRO toehold-mediated mismatch discrimination and RNA off-target reduction.,toehold_mismatch_discrimination_score_proxy,,,,no,brothers_aso_pna_toxicity_mitigation.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated efficacy-to-ALT safety-margin score for parent ASO versus BRO designs.,therapeutic_margin_score_proxy,,,,no,brothers_aso_pna_toxicity_mitigation.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated long-duration activity index for APOC3 GalNAc-siRNA scaffold scenarios.,duration_index_proxy,,,,no,apoc3_galnac_sirna_sar_safety.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated rodent/NHP/cell tolerability proxy integrating off-target and ALT context.,tolerability_score_proxy,,,,no,apoc3_galnac_sirna_sar_safety.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated lower-limit-of-quantification proxy for GalNAc-siRNA LC/MS bioanalysis.,lloq_ng_per_mL_proxy,,,,no,galnac_sirna_lcms_bioanalysis.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated suitability score for deriving PK/TK parameters from siRNA bioanalysis workflow.,pk_parameter_suitability_score_proxy,,,,no,galnac_sirna_lcms_bioanalysis.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated fibrosis-improvement score for oral modified miR-29a-like nucleic-acid therapy context.,fibrosis_improvement_score_proxy,,,,no,oral_mir29a_liver_fibrosis_na.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Delivery system context; this source emphasizes no-DDS oral modified nucleic-acid delivery.,delivery_system,,,,no,oral_mir29a_liver_fibrosis_na.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated liver-editing efficiency proxy for LNP-CRISPR-Cas9 HAO1/Hao1 PH1 context.,liver_editing_efficiency_fraction_proxy,,,,no,lnp_crispr_hao1_ph1_safety.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated off-target indel signal proxy for CRISPR delivery specificity context.,predicted_offtarget_indel_signal_proxy,,,,no,lnp_crispr_hao1_ph1_safety.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated liver toxicity signal proxy for long-term LNP-CRISPR safety context.,liver_toxicity_signal_proxy,,,,no,lnp_crispr_hao1_ph1_safety.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated cell-viability proxy for PS and PS/LNA modified ASO tolerability context.,cell_viability_fraction_proxy,,,,no,ps_lna_hiv_aso_internalization_toxicity.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated cytoplasmic internalization proxy for vehicle-free PS/LNA ASO uptake context.,cytoplasmic_internalization_score_proxy,,,,no,ps_lna_hiv_aso_internalization_toxicity.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated seed-mediated off-target binding proxy for ESC/ESC+ GalNAc-siRNA safety context.,seed_mediated_offtarget_binding_proxy,,,,no,escplus_seed_pairing_safety_mechanism.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated ALT elevation liability proxy for GalNAc-siRNA seed-offtarget hepatotoxicity context.,ALT_elevation_liability_proxy,,,,no,escplus_seed_pairing_safety_mechanism.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated therapeutic-window proxy integrating activity retention and ALT liability.,therapeutic_window_proxy,,,,no,escplus_seed_pairing_safety_mechanism.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated backbone-charge proxy for LNA-phosphothiotriester and comparator oligonucleotides.,estimated_backbone_charge_fraction_proxy,,,,no,lna_phosphothiotriester_splice_switching.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated splice-switching activity proxy for SSO chemistry context.,splice_switching_activity_proxy,,,,no,lna_phosphothiotriester_splice_switching.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated liver metabolic-hepatotoxicity proxy for FXR/JNK/G0s2 DILI context.,metabolic_hepatotoxicity_score_proxy,,,,no,fxr_jnk_g0s2_dili_context.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated proxy for RNase H1-dependent off-target reduction of very long pre-mRNA transcripts by high-affinity gapmer ASOs.,very_long_pre_mRNA_offtarget_reduction_proxy,,,,no,gapmer_rnaseh1_long_premrna_hepatotox.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated transaminase-liability proxy for ASO chemistry/scenario context.,ALT_AST_liability_fold_proxy,,,,no,gapmer_rnaseh1_long_premrna_hepatotox.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated inverse of broad off-target transcript reduction; higher means more selective.,transcriptome_selectivity_index_proxy,,,,no,gapmer_rnaseh1_long_premrna_hepatotox.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated method-specificity proxy for hybridization LC-MS/MS free-ASO payload quantification.,method_specificity_score_proxy,,,,no,aoc_free_aso_payload_bioanalysis.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated sample-preparation recovery proxy for free ASO payload measurement.,free_ASO_recovery_proxy,,,,no,aoc_free_aso_payload_bioanalysis.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated HSC activation proxy for MASLD/fibrosis context.,HSC_activation_score_proxy,,,,no,pum1_exosome_masld_hsc_fibrosis.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated proxy for PUM1-enriched exosome protection against HSC activation/lipotoxic injury.,PUM1_enriched_exosome_protection_proxy,,,,no,pum1_exosome_masld_hsc_fibrosis.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated proxy for early immune effector/apoptotic protein activation after bepirovirsen treatment.,immune_effector_activation_score_proxy,,,,no,bepirovirsen_immunomodulation_alt.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated proxy for ALT association with liver/apoptosis-specific protein signals and responder biology.,ALT_increase_association_score_proxy,,,,no,bepirovirsen_immunomodulation_alt.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated proxy for HBsAg decline/response context linked to bepirovirsen treatment.,HBsAg_decline_response_score_proxy,,,,no,bepirovirsen_immunomodulation_alt.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated proxy for ASO stability/nuclease-resistance context associated with SNA modification.,nuclease_resistance_score_proxy,,,,no,sna_aso_kidney_systemic_safety.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,"Generated proxy for liver damage/safety comparison among SNA, DNA, and MOE ASO contexts.",liver_damage_liability_score_proxy,,,,no,sna_aso_kidney_systemic_safety.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated proxy for enhanced endosomal release of RNA payloads from polyamine-incorporated LNPs.,endosomal_escape_score_proxy,,,,no,polyamine_plnp_rna_delivery_safety.csv,,literature_grounded_generated
,,generated_numeric_or_categorical,Generated proxy for liver-toxicity liability in LNP/p-LNP delivery scenarios.,liver_toxicity_liability_score_proxy,,,,no,polyamine_plnp_rna_delivery_safety.csv,,literature_grounded_generated
0_to_1_proxy_or_categorical,,,Generated proxy for ASO off-target burden observed at RNA/transcriptome level.,rna_level_offtarget_burden_score_proxy,,literature_grounded_generated,,,aso_multiomics_time_resolved_safety.csv,float_or_string,
0_to_1_proxy_or_categorical,,,Generated proxy for corresponding off-target signal observed at protein/proteomics level.,protein_level_offtarget_burden_score_proxy,,literature_grounded_generated,,,aso_multiomics_time_resolved_safety.csv,float_or_string,
0_to_1_proxy_or_categorical,,,Generated proxy for RNA/protein mismatch indicating why proteomics can complement RNA-focused off-target assessment.,rna_protein_offtarget_discordance_score_proxy,,literature_grounded_generated,,,aso_multiomics_time_resolved_safety.csv,float_or_string,
0_to_1_proxy_or_categorical,,,Generated proxy for ALT signal in GalNAc-siRNA preclinical safety scenarios.,ALT_signal_score_proxy,,literature_grounded_generated,,,sln360_galnac_sirna_preclinical_toxicology.csv,float_or_string,
0_to_1_proxy_or_categorical,,,Generated proxy for known GalNAc-siRNA platform-related microscopic liver/kidney findings.,microscopic_platform_effect_score_proxy,,literature_grounded_generated,,,sln360_galnac_sirna_preclinical_toxicology.csv,float_or_string,
0_to_1_proxy_or_categorical,,,Generated proxy for liver/Kupffer-cell targeting by biomimetic siRNA nanoparticles.,liver_or_Kupffer_targeting_score_proxy,,literature_grounded_generated,,,kupffer_biomimetic_sirna_srli.csv,float_or_string,
0_to_1_proxy_or_categorical,,,Generated proxy for NLRP1/inflammasome/pyroptosis pathway activity in sepsis-related liver injury context.,pyroptosis_inflammasome_score_proxy,,literature_grounded_generated,,,kupffer_biomimetic_sirna_srli.csv,float_or_string,
0_to_1_proxy_or_categorical,,,Generated proxy for ASO-induced EZH2 exon 14 skipping in liver/HCC contexts.,exon14_skipping_score_proxy,,literature_grounded_generated,,,ezh2_exon_skipping_hcc_aso.csv,float_or_string,
0_to_1_proxy_or_categorical,,,Generated proxy for residual H3K27me3 epigenetic signal after EZH2 splice-switching ASO intervention.,H3K27me3_residual_score_proxy,,literature_grounded_generated,,,ezh2_exon_skipping_hcc_aso.csv,float_or_string,
0_to_1_proxy_or_categorical,,,Generated proxy for extrahepatic DRG/sciatic nerve exposure after systemic HDO/ASO administration.,extrahepatic_distribution_score_proxy,,literature_grounded_generated,,,systemic_hdo_drg_sciatic_delivery.csv,float_or_string,
0_to_1_proxy_or_categorical,,,Generated proxy for relative HDO delivery/potency improvement over parent single-stranded ASO.,potency_improvement_vs_parent_ASO_score_proxy,,literature_grounded_generated,,,systemic_hdo_drg_sciatic_delivery.csv,float_or_string,
0_to_1_proxy_or_categorical,,,Generated proxy for ferroptosis induction or suppression in hepatic stellate cell/fibrosis contexts.,ferroptosis_score_proxy,,literature_grounded_generated,,,xist_hsc_ferroptosis_fibrosis.csv,float_or_string,
0_to_1_proxy_or_categorical,,,Generated proxy for fibrosis-related hydroxyproline signal in mouse liver contexts.,hydroxyproline_HYP_fibrosis_score_proxy,,literature_grounded_generated,,,xist_hsc_ferroptosis_fibrosis.csv,float_or_string,
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing GalNAc-siRNA CIDEB target silencing in vitro/in vivo.,CIDEB_knockdown_score_proxy,,,,yes,galnac_sicidEB_mash_safety.csv,,literature_grounded_generated
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing steatosis/fibrosis benefit context in MASH models.,MASH_steatosis_or_fibrosis_benefit_score_proxy,,,,yes,galnac_sicidEB_mash_safety.csv,,literature_grounded_generated
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing late-onset CNS toxicity context for ASO chemistry scenarios.,late_onset_neurotoxicity_score_proxy,,,,yes,aso_late_onset_neurotox_chemical_modifications.csv,,literature_grounded_generated
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing preservation of target knockdown despite toxicity-mitigating chemistry.,target_knockdown_preservation_score_proxy,,,,yes,aso_late_onset_neurotox_chemical_modifications.csv,,literature_grounded_generated
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing liver-enzyme toxicity signal context.,ALT_AST_toxicity_signal_score_proxy,,,,yes,galnac_sicebpb_masld_liver_homeostasis.csv,,literature_grounded_generated
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing liver-function/metabolic improvement context.,liver_homeostasis_benefit_score_proxy,,,,yes,galnac_sicebpb_masld_liver_homeostasis.csv,,literature_grounded_generated
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing cellular uptake of disulfide-unit-masked ODNs.,cellular_uptake_score_proxy,,,,yes,trivalent_disulfide_odn_delivery.csv,,literature_grounded_generated
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing thiol-exchange dependence of uptake.,thiol_exchange_dependency_score_proxy,,,,yes,trivalent_disulfide_odn_delivery.csv,,literature_grounded_generated
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing macrophage pyroptosis in MASH/Ox-mtDNA/NLRP3 contexts.,macrophage_pyroptosis_score_proxy,,,,yes,mptp_oxmtdna_mash_pyroptosis.csv,,literature_grounded_generated
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing NLRP3 inflammasome activation context.,NLRP3_activation_score_proxy,,,,yes,mptp_oxmtdna_mash_pyroptosis.csv,,literature_grounded_generated
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing NG2/CSPG4 expression or intervention state in fibrosis models.,NG2_CSPG4_expression_score_proxy,,,,yes,ng2_cspg4_sirna_liver_fibrosis.csv,,literature_grounded_generated
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing collagen/fibrosis burden context.,collagen_fibrosis_score_proxy,,,,yes,ng2_cspg4_sirna_liver_fibrosis.csv,,literature_grounded_generated
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing tumor-directed LNP nucleic-acid delivery context.,tumor_delivery_score_proxy,,,,yes,hnscc_lnp_liver_detargeting.csv,,literature_grounded_generated
0-1 proxy score unless otherwise specified,,numeric_or_string,Generated score representing off-target liver hepatocyte delivery context.,liver_hepatocyte_delivery_score_proxy,,,,yes,hnscc_lnp_liver_detargeting.csv,,literature_grounded_generated