Update README.md
Browse files
README.md
CHANGED
|
@@ -14,51 +14,45 @@ tags:
|
|
| 14 |
|
| 15 |
# Clarus Clinical Stability Benchmark
|
| 16 |
|
| 17 |
-
The Clarus Clinical Stability Benchmark evaluates whether machine learning models can infer latent system instability from interacting proxy signals across multiple physiological and operational regimes.
|
| 18 |
-
|
| 19 |
-
Unlike traditional tabular benchmarks that reward threshold detection or single-feature correlations, Clarus datasets are designed so that instability emerges from interactions between variables.
|
| 20 |
-
|
| 21 |
-
The benchmark therefore measures stability reasoning rather than pattern memorization.
|
| 22 |
-
|
| 23 |
The Clarus Clinical Stability Benchmark evaluates whether machine learning models can detect **latent instability in complex clinical systems**.
|
| 24 |
|
| 25 |
-
Most tabular benchmarks
|
| 26 |
-
|
| 27 |
-
This benchmark instead evaluates **reasoning about interacting system signals** that determine whether a system remains stable or moves toward collapse.
|
| 28 |
|
| 29 |
-
|
| 30 |
|
| 31 |
---
|
| 32 |
|
| 33 |
# Benchmark Concept
|
| 34 |
|
| 35 |
-
|
| 36 |
|
| 37 |
-
|
| 38 |
|
| 39 |
Examples include:
|
| 40 |
|
| 41 |
-
- circulatory compensation failure
|
| 42 |
-
- microvascular perfusion loss
|
| 43 |
-
- metabolic energy collapse
|
| 44 |
-
- respiratory control failure
|
| 45 |
-
- endocrine dysregulation
|
| 46 |
-
- thermoregulatory breakdown
|
| 47 |
-
- coagulation instability
|
| 48 |
-
- hospital operational overload
|
| 49 |
|
| 50 |
-
Each dataset
|
|
|
|
| 51 |
|
| 52 |
-
The
|
| 53 |
|
| 54 |
-
Models must infer instability from
|
| 55 |
|
| 56 |
---
|
| 57 |
|
| 58 |
# Included Datasets
|
| 59 |
|
| 60 |
-
| Regime | Dataset
|
| 61 |
-
|---
|
| 62 |
| Hemodynamic collapse | ClarusC64/clinical-hemodynamic-collapse-v0.1 |
|
| 63 |
| Sepsis trajectory instability | ClarusC64/clinical-sepsis-trajectory-instability-v0.1 |
|
| 64 |
| Intervention delay failure | ClarusC64/clinical-intervention-delay-failure-v0.1 |
|
|
@@ -75,18 +69,20 @@ Models must infer instability from **interacting proxy signals**.
|
|
| 75 |
| Coagulation instability | ClarusC64/clinical-coagulation-instability-v0.1 |
|
| 76 |
| Hospital operational collapse | ClarusC64/clinical-hospital-operational-collapse-v0.1 |
|
| 77 |
|
| 78 |
-
Each dataset
|
| 79 |
-
|
| 80 |
-
|
| 81 |
-
|
| 82 |
-
scorer.py
|
| 83 |
README.md
|
| 84 |
|
|
|
|
| 85 |
---
|
| 86 |
|
| 87 |
# Evaluation Protocol
|
| 88 |
|
| 89 |
-
|
|
|
|
|
|
|
| 90 |
scenario_id,prediction
|
| 91 |
|
| 92 |
|
|
@@ -97,20 +93,23 @@ MC101,0
|
|
| 97 |
MC102,1
|
| 98 |
|
| 99 |
|
| 100 |
-
|
|
|
|
|
|
|
| 101 |
|
| 102 |
|
| 103 |
python scorer.py --predictions predictions.csv --truth data/test.csv --output metrics.json
|
| 104 |
|
| 105 |
|
| 106 |
-
|
|
|
|
|
|
|
| 107 |
|
| 108 |
- accuracy
|
| 109 |
- precision
|
| 110 |
- recall
|
| 111 |
- f1
|
| 112 |
- confusion matrix
|
| 113 |
-
- dataset integrity diagnostics
|
| 114 |
|
| 115 |
---
|
| 116 |
|
|
@@ -122,7 +121,9 @@ The benchmark supports three evaluation settings.
|
|
| 122 |
|
| 123 |
Train and test on the same dataset.
|
| 124 |
|
| 125 |
-
|
|
|
|
|
|
|
| 126 |
|
| 127 |
---
|
| 128 |
|
|
@@ -132,15 +133,12 @@ Train on one regime and test on another.
|
|
| 132 |
|
| 133 |
Example:
|
| 134 |
|
| 135 |
-
Train
|
| 136 |
-
|
| 137 |
-
clinical-hemodynamic-collapse
|
| 138 |
|
| 139 |
-
|
| 140 |
|
| 141 |
-
|
| 142 |
-
|
| 143 |
-
Large performance drops indicate the model learned **surface patterns rather than stability reasoning**.
|
| 144 |
|
| 145 |
---
|
| 146 |
|
|
@@ -148,17 +146,21 @@ Large performance drops indicate the model learned **surface patterns rather tha
|
|
| 148 |
|
| 149 |
Train on multiple datasets simultaneously.
|
| 150 |
|
| 151 |
-
Evaluate
|
|
|
|
|
|
|
|
|
|
|
|
|
| 152 |
|
| 153 |
---
|
| 154 |
|
| 155 |
# Dataset Design Principles
|
| 156 |
|
| 157 |
-
The Clarus datasets follow several design rules.
|
| 158 |
|
| 159 |
### No Single-Feature Dominance
|
| 160 |
|
| 161 |
-
No observable variable strongly predicts the label
|
| 162 |
|
| 163 |
Target:
|
| 164 |
|
|
@@ -168,7 +170,7 @@ Target:
|
|
| 168 |
|
| 169 |
### Interaction-Based Labels
|
| 170 |
|
| 171 |
-
Instability emerges from interactions between multiple variables.
|
| 172 |
|
| 173 |
---
|
| 174 |
|
|
@@ -182,26 +184,40 @@ This prevents trivial heuristics.
|
|
| 182 |
|
| 183 |
### Decoy Variables
|
| 184 |
|
| 185 |
-
Some variables appear meaningful but
|
| 186 |
|
| 187 |
---
|
| 188 |
|
| 189 |
### Hidden Generative Logic
|
| 190 |
|
| 191 |
-
The dataset generator and
|
| 192 |
|
| 193 |
Models must infer instability from proxy signals.
|
| 194 |
|
| 195 |
---
|
| 196 |
|
| 197 |
-
#
|
|
|
|
|
|
|
| 198 |
|
| 199 |
-
|
| 200 |
|
| 201 |
-
|
|
|
|
| 202 |
|
| 203 |
---
|
| 204 |
-
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 205 |
|
| 206 |
---
|
| 207 |
|
|
@@ -209,13 +225,11 @@ They are designed for research into **latent stability reasoning**, not clinical
|
|
| 209 |
|
| 210 |
The benchmark supports research into:
|
| 211 |
|
| 212 |
-
- stability reasoning
|
| 213 |
-
- interaction-based tabular
|
| 214 |
-
- cross-domain
|
| 215 |
-
- clinical early warning
|
| 216 |
-
-
|
| 217 |
-
|
| 218 |
-
The Clarus benchmark evaluates whether models can detect latent instability across interacting system regimes rather than learning surface patterns within a single dataset.
|
| 219 |
|
| 220 |
---
|
| 221 |
|
|
|
|
| 14 |
|
| 15 |
# Clarus Clinical Stability Benchmark
|
| 16 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 17 |
The Clarus Clinical Stability Benchmark evaluates whether machine learning models can detect **latent instability in complex clinical systems**.
|
| 18 |
|
| 19 |
+
Most tabular benchmarks reward models for learning correlations within a single dataset.
|
| 20 |
+
The Clarus benchmark instead evaluates whether models can infer instability from **interacting proxy signals across multiple physiological and operational regimes**.
|
|
|
|
| 21 |
|
| 22 |
+
Each dataset represents a simplified regime in which instability emerges from multi-variable interaction rather than single-variable thresholds.
|
| 23 |
|
| 24 |
---
|
| 25 |
|
| 26 |
# Benchmark Concept
|
| 27 |
|
| 28 |
+
In real clinical systems, deterioration rarely occurs because one measurement crosses a threshold.
|
| 29 |
|
| 30 |
+
Instead, instability emerges when several components drift simultaneously.
|
| 31 |
|
| 32 |
Examples include:
|
| 33 |
|
| 34 |
+
- circulatory compensation failure
|
| 35 |
+
- microvascular perfusion loss
|
| 36 |
+
- metabolic energy collapse
|
| 37 |
+
- respiratory control failure
|
| 38 |
+
- endocrine dysregulation
|
| 39 |
+
- thermoregulatory breakdown
|
| 40 |
+
- coagulation instability
|
| 41 |
+
- hospital operational overload
|
| 42 |
|
| 43 |
+
Each dataset exposes a different regime while keeping the underlying structure similar:
|
| 44 |
+
**instability arises from interacting system signals.**
|
| 45 |
|
| 46 |
+
The generative rules that determine the labels are intentionally not published.
|
| 47 |
|
| 48 |
+
Models must infer instability from observable proxies.
|
| 49 |
|
| 50 |
---
|
| 51 |
|
| 52 |
# Included Datasets
|
| 53 |
|
| 54 |
+
| Stability Regime | Dataset |
|
| 55 |
+
|---|---|
|
| 56 |
| Hemodynamic collapse | ClarusC64/clinical-hemodynamic-collapse-v0.1 |
|
| 57 |
| Sepsis trajectory instability | ClarusC64/clinical-sepsis-trajectory-instability-v0.1 |
|
| 58 |
| Intervention delay failure | ClarusC64/clinical-intervention-delay-failure-v0.1 |
|
|
|
|
| 69 |
| Coagulation instability | ClarusC64/clinical-coagulation-instability-v0.1 |
|
| 70 |
| Hospital operational collapse | ClarusC64/clinical-hospital-operational-collapse-v0.1 |
|
| 71 |
|
| 72 |
+
Each dataset repository contains:
|
| 73 |
+
data/train.csv
|
| 74 |
+
data/test.csv
|
| 75 |
+
scorer.py
|
|
|
|
| 76 |
README.md
|
| 77 |
|
| 78 |
+
|
| 79 |
---
|
| 80 |
|
| 81 |
# Evaluation Protocol
|
| 82 |
|
| 83 |
+
Predictions must follow the format:
|
| 84 |
+
|
| 85 |
+
|
| 86 |
scenario_id,prediction
|
| 87 |
|
| 88 |
|
|
|
|
| 93 |
MC102,1
|
| 94 |
|
| 95 |
|
| 96 |
+
Evaluation is performed using the **scorer located in the dataset repository**.
|
| 97 |
+
|
| 98 |
+
Example:
|
| 99 |
|
| 100 |
|
| 101 |
python scorer.py --predictions predictions.csv --truth data/test.csv --output metrics.json
|
| 102 |
|
| 103 |
|
| 104 |
+
The `--truth` path refers to the dataset's local `data/test.csv` file.
|
| 105 |
+
|
| 106 |
+
Metrics reported include:
|
| 107 |
|
| 108 |
- accuracy
|
| 109 |
- precision
|
| 110 |
- recall
|
| 111 |
- f1
|
| 112 |
- confusion matrix
|
|
|
|
| 113 |
|
| 114 |
---
|
| 115 |
|
|
|
|
| 121 |
|
| 122 |
Train and test on the same dataset.
|
| 123 |
|
| 124 |
+
Purpose:
|
| 125 |
+
|
| 126 |
+
Measure baseline performance within a single stability regime.
|
| 127 |
|
| 128 |
---
|
| 129 |
|
|
|
|
| 133 |
|
| 134 |
Example:
|
| 135 |
|
| 136 |
+
Train → clinical-hemodynamic-collapse-v0.1
|
| 137 |
+
Test → clinical-microcirculation-instability-v0.1
|
|
|
|
| 138 |
|
| 139 |
+
Purpose:
|
| 140 |
|
| 141 |
+
Determine whether models learn **general stability reasoning** rather than dataset-specific correlations.
|
|
|
|
|
|
|
| 142 |
|
| 143 |
---
|
| 144 |
|
|
|
|
| 146 |
|
| 147 |
Train on multiple datasets simultaneously.
|
| 148 |
|
| 149 |
+
Evaluate performance across all regimes.
|
| 150 |
+
|
| 151 |
+
Purpose:
|
| 152 |
+
|
| 153 |
+
Test whether models can learn shared stability representations across physiological systems.
|
| 154 |
|
| 155 |
---
|
| 156 |
|
| 157 |
# Dataset Design Principles
|
| 158 |
|
| 159 |
+
The Clarus datasets follow several explicit design rules.
|
| 160 |
|
| 161 |
### No Single-Feature Dominance
|
| 162 |
|
| 163 |
+
No observable variable strongly predicts the label independently.
|
| 164 |
|
| 165 |
Target:
|
| 166 |
|
|
|
|
| 170 |
|
| 171 |
### Interaction-Based Labels
|
| 172 |
|
| 173 |
+
Instability emerges from interactions between multiple variables rather than isolated thresholds.
|
| 174 |
|
| 175 |
---
|
| 176 |
|
|
|
|
| 184 |
|
| 185 |
### Decoy Variables
|
| 186 |
|
| 187 |
+
Some variables appear meaningful but do not determine the label independently.
|
| 188 |
|
| 189 |
---
|
| 190 |
|
| 191 |
### Hidden Generative Logic
|
| 192 |
|
| 193 |
+
The dataset generator and rule equations are intentionally not published.
|
| 194 |
|
| 195 |
Models must infer instability from proxy signals.
|
| 196 |
|
| 197 |
---
|
| 198 |
|
| 199 |
+
# Baseline Results
|
| 200 |
+
|
| 201 |
+
Reference baseline experiments are provided in:
|
| 202 |
|
| 203 |
+
baseline_results.md
|
| 204 |
|
| 205 |
+
|
| 206 |
+
These establish approximate difficulty levels for common tabular models.
|
| 207 |
|
| 208 |
---
|
| 209 |
+
|
| 210 |
+
# Benchmark Architecture
|
| 211 |
+
|
| 212 |
+
The benchmark can be interpreted as observing a **shared stability manifold** through different clinical regimes.
|
| 213 |
+
|
| 214 |
+
Each dataset exposes a different control system while preserving the underlying concept of instability emerging from interacting signals.
|
| 215 |
+
|
| 216 |
+
Additional details are provided in:
|
| 217 |
+
|
| 218 |
+
|
| 219 |
+
stability_manifold.md
|
| 220 |
+
|
| 221 |
|
| 222 |
---
|
| 223 |
|
|
|
|
| 225 |
|
| 226 |
The benchmark supports research into:
|
| 227 |
|
| 228 |
+
- system stability reasoning
|
| 229 |
+
- interaction-based tabular learning
|
| 230 |
+
- cross-domain generalization
|
| 231 |
+
- clinical early warning modeling
|
| 232 |
+
- infrastructure and system risk detection
|
|
|
|
|
|
|
| 233 |
|
| 234 |
---
|
| 235 |
|