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README.md
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splits:
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num_bytes: 3963751573
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num_examples: 408
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download_size: 3964118620
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dataset_size: 3963751573
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- config_name: nuclei
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features:
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- name: image
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dtype: image
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- name: patient_id
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dtype: int32
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- name: roi_id
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dtype: int32
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dtype: float32
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dtype: string
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splits:
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num_bytes: 96942013
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num_examples: 67
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- name: validation
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num_bytes: 55692546
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num_examples: 36
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- name: test
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num_bytes: 65050351
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num_examples: 32
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download_size: 217694424
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dataset_size: 217684910
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- config_name: pdl1
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features:
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- name: image
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dtype: image
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- name: patient_id
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dtype: int32
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dtype: int32
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dtype: string
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dtype: string
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dtype: float32
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dtype: string
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splits:
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num_bytes: 1057978657
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num_examples: 185
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- name: validation
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num_bytes: 483032882
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num_examples: 61
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num_bytes: 51005544
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num_examples: 98
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download_size: 1592071431
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dataset_size: 1592017083
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configs:
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- config_name: he
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---
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---
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+
license: cc-by-nc-sa-4.0
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+
task_categories:
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- image-segmentation
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- object-detection
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+
language:
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- en
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tags:
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- medical
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- pathology
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- histopathology
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- h-and-e
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- pd-l1
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- lung
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- nsclc
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- ignite
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size_categories:
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- n<1K
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configs:
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- config_name: he
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data_files:
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- split: train
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path: he/train-*
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- config_name: pdl1
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data_files:
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- split: train
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path: pdl1/train-*
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- split: validation
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path: pdl1/validation-*
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- split: test
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path: pdl1/test-*
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- config_name: nuclei
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data_files:
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- split: train
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path: nuclei/train-*
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- split: validation
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path: nuclei/validation-*
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- split: test
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path: nuclei/test-*
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---
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# IGNITE Data Toolkit (mirror)
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Mirror of the **IGNITE Data Toolkit** by Spronck et al. (Radboud UMC),
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originally distributed on [Zenodo (10.5281/zenodo.15674785)](https://zenodo.org/records/15674785)
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and accompanied by [DIAGNijmegen/ignite-data-toolkit](https://github.com/DIAGNijmegen/ignite-data-toolkit).
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The dataset accompanies *"A tissue and cell-level annotated H&E and PD-L1 histopathology image
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dataset in non-small cell lung cancer"* ([arXiv:2507.16855](https://arxiv.org/abs/2507.16855)).
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**License:** [CC BY-NC-SA 4.0](https://creativecommons.org/licenses/by-nc-sa/4.0/) —
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non-commercial, share-alike. Attribution to the original authors is required.
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## Contents
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155 unique patients, 887 fully annotated regions of interest from a multi-stain,
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multi-centric, multi-scanner cohort (Radboud UMC, Sacro Cuore Don Calabria, TCGA-LUAD/LUSC).
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The release splits into three task-defined subsets, exposed here as named configs:
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| Config | Task | ROIs |
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|----------|---------------------------------------|-----:|
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| `he` | H&E tissue compartment segmentation | 408 |
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| `pdl1` | PD-L1+ tumor cell detection | 344 |
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| `nuclei` | PD-L1 IHC nuclei detection | 135 |
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## H&E tissue segmentation (`he` config)
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Each row is **one ROI** with paired image/mask in two field-of-view variants:
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| Column | Type | Description |
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|------------------------|---------|--------------------------------------------------------------|
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| `image` | `Image` | Base ROI (inner annotated region only) |
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| `mask` | `Image` | 16-class pixel mask aligned to `image` |
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| `image_with_context` | `Image` | Same ROI extended to a 1792x1792 view (annotated context) |
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| `mask_with_context` | `Image` | 16-class pixel mask aligned to `image_with_context` |
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| `validation_fold` | string | 5-fold CV assignment (`fold0`..`fold4`) |
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| `patient_id` | int32 | Patient identifier |
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| `roi_id` | int32 | ROI index within patient |
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| `name` | string | `patient<id>_he_roi<idx>` (matches the original release) |
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| `source` | string | `rumc`, `scdc`, or `tcga` |
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| `specimen_type` | string | `resection`, `biopsy`, or `tissue_microarray` |
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| `organ` | string | Anatomical site (lung, liver, bone, brain, ...) |
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| `histological_subtype` | string | `adenocarcinoma`, `squamous_cell_carcinoma`, ... |
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| `stain` | string | Always `H&E` for this config |
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| `scanner` | string | WSI scanner model |
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| `shape` | string | Original `(height, width)` tuple as a string |
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| `area_mm2` | float32 | Annotated tissue area in mm^2 |
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| `original_tcga_id` | string | TCGA case ID for TCGA-sourced ROIs (empty otherwise) |
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Labels (also shipped as `he_label_map.json`):
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| ID | Class | ID | Class |
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|---:|----------------------|---:|----------------------|
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| 0 | Unannotated | 9 | Erythrocytes |
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| 1 | Background | 10 | Bronchial epithelium |
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| 2 | Tumor epithelium | 11 | Mucus/Plasma/Fluids |
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| 3 | Reactive epithelium | 12 | Cartilage/Bone |
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| 4 | Stroma | 13 | Macrophages |
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| 5 | Inflammation | 14 | Muscle |
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| 6 | Alveolar tissue | 15 | Liver |
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| 7 | Fatty tissue | 16 | Keratinization |
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| 8 | Necrotic tissue | | |
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> **Mirror-specific note:** In the original Zenodo release, base ROI masks (the inner-crop view)
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> store class label `L` as the byte value `(256 - L) mod 256` (e.g. label 4 -> byte 252).
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> The `_with_context` masks already store labels directly. In this HuggingFace mirror **both
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> `mask` and `mask_with_context` are written with the canonical 0..16 labels** — base masks were
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> pre-decoded during upload, so downstream code does not need to handle the encoding quirk.
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The `he` config has a single `train` split — use `validation_fold` to assemble
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5-fold cross-validation as recommended by the paper.
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## PD-L1 / nuclei detection (`pdl1`, `nuclei` configs)
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+
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These configs hold images plus per-image metadata only (same columns as `he` except no
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`mask`/`_with_context` fields and no `validation_fold`). The detection ground truth is
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in **MS-COCO JSON** format and is shipped as raw sidecar files because COCO-style nested
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annotations are a poor fit for columnar parquet:
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| Path | Subset | Notes |
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|-------------------------------------|--------|--------------------------------------------|
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| `coco/pdl1_annotations.json` | pdl1 | Main annotations |
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| `coco/pdl1_test_set_all_readers.json` | pdl1 | Multi-reader test set |
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| `coco/nuclei_annotations.json` | nuclei | Main annotations |
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| `coco/nuclei_test_set_all_readers.json` | nuclei | Multi-reader test set |
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Use the row's `name` field (== `image_id` in COCO `images[*].file_name = "<name>.png"`)
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to look up bounding-box / point annotations.
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Splits follow `data_overview.csv` directly (no fold column for the detection tasks).
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## Loading
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+
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```python
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from datasets import load_dataset
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# H&E tissue segmentation (single train split, use validation_fold for 5-fold CV)
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+
he = load_dataset("Angelou0516/IGNITE", "he", split="train")
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+
print(he[0]["mask"]) # PIL Image L-mode, labels 0..16
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+
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# PD-L1+ tumor cell detection
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pdl1 = load_dataset("Angelou0516/IGNITE", "pdl1")
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+
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# PD-L1 IHC nuclei detection
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nuc = load_dataset("Angelou0516/IGNITE", "nuclei")
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+
```
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+
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For detection COCO annotations, download the JSON sidecars with `huggingface_hub.hf_hub_download`.
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+
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## Sidecar files (raw)
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+
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+
- `he_label_map.json` — class id -> name
|
| 152 |
+
- `data_overview.csv` — per-ROI metadata (887 rows x 17 cols), authoritative for splits / folds
|
| 153 |
+
- `coco/*.json` — detection annotations (4 files, see table above)
|
| 154 |
+
|
| 155 |
+
## Citation
|
| 156 |
+
|
| 157 |
+
```bibtex
|
| 158 |
+
@article{Spronck2025ignite,
|
| 159 |
+
title = {A tissue and cell-level annotated H\&E and PD-L1 histopathology image dataset in non-small cell lung cancer},
|
| 160 |
+
author = {Spronck, Joey and van Eekelen, Leander and van Midden, Dominique and others},
|
| 161 |
+
journal = {arXiv preprint arXiv:2507.16855},
|
| 162 |
+
year = {2025},
|
| 163 |
+
doi = {10.48550/arXiv.2507.16855}
|
| 164 |
+
}
|
| 165 |
+
```
|
| 166 |
+
|
| 167 |
+
Mirror maintained by `Angelou0516`. For the official authoritative release see the
|
| 168 |
+
[Zenodo record](https://zenodo.org/records/15674785) and
|
| 169 |
+
[GitHub toolkit](https://github.com/DIAGNijmegen/ignite-data-toolkit).
|