---
library_name: tedbench
license: bsd-3-clause
pipeline_tag: graph-ml
tags:
- protein
- structure
- fold-classification
- tedbench
---

# TEDBench — Fine-tuned from pretrained MiAE (structure only)

**Variant:** `miae_l`  |  **Parameters:** 339M  |  **Layers:** 24  |  **Hidden dim:** 1024  |  **Attn heads:** 16

This **MiAEClassifier** was initialised from a pretrained MiAE and fine-tuned on TEDBench for fold classification.

Part of the [TEDBench](https://github.com/BorgwardtLab/TEDBench) benchmark for protein fold classification (ICML 2026), introduced in the paper [Protein Fold Classification at Scale: Benchmarking and Pretraining](https://arxiv.org/abs/2605.18552).

- **Code:** [GitHub Repository](https://github.com/BorgwardtLab/TEDBench)
- **Paper:** [arXiv:2605.18552](https://arxiv.org/abs/2605.18552)

MiAE is an SE(3)-invariant masked autoencoder that masks up to 90% of backbone frames and reconstructs the full structure with a lightweight decoder.

## Architecture sizes

| Variant | Params | Layers | Hidden dim | Attn heads |
|---------|-------:|-------:|-----------:|-----------:|
| `miae_s` | 29 M | 6 | 512 | 8 |
| `miae_b` | 102 M | 12 | 768 | 12 |
| `miae_l` | 339 M | 24 | 1 024 | 16 |

Append `+model.use_seq_input=true` to `miae_b` for the **+seq** variant.

## Usage

### Load from the HuggingFace Hub

```python
from tedbench.utils.io import load_from_hf

model = load_from_hf("TEDBench/miae-l-ft")
model.eval()
```

### From a Lightning checkpoint

```python
from tedbench.model import MiAEClassifier

model = MiAEClassifier.load_from_checkpoint("model.ckpt", weights_only=False)
model.eval()
```

## Citation

```bibtex
@inproceedings{chen2026tedbench,
  title={Protein Fold Classification at Scale: Benchmarking and Pretraining},
  author={Chen, Dexiong and Manolache, Andrei and Niepert, Mathias and Borgwardt, Karsten},
  booktitle={Proceedings of the 43rd International Conference on Machine Learning},
  year={2026}
}
```