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README.md
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library_name: transformers
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tags: []
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---
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# NOTE
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The GitHub with the implementation and requirements can be found [here](https://github.com/Synthyra/FastPLMs.git).
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# DPLM2
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Synthyra DPLM2 checkpoints are HuggingFace AutoModel compatible and include FastPLMs embedding helpers.
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## Supported models
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```python
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model_dict = {
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"Synthyra/DPLM2-150M": "airkingbd/dplm2_150m",
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"Synthyra/DPLM2-650M": "airkingbd/dplm2_650m",
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"Synthyra/DPLM2-3B": "airkingbd/dplm2_3b",
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}
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```
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## Use with transformers
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```python
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import torch
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from transformers import AutoModel, AutoModelForMaskedLM
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model_path = "Synthyra/DPLM2-150M"
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model = AutoModel.from_pretrained(model_path, trust_remote_code=True, dtype=torch.float16).eval()
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tokenizer = model.tokenizer
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batch = tokenizer(["MPRTEIN", "MSEQWENCE"], padding=True, return_tensors="pt")
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with torch.no_grad():
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hidden = model(**batch).last_hidden_state
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mlm = AutoModelForMaskedLM.from_pretrained(model_path, trust_remote_code=True, dtype=torch.float16).eval()
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with torch.no_grad():
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logits = mlm(**batch).logits
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```
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## DPLM2 modality types
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DPLM2 infers `type_ids` automatically from `input_ids` and `attention_mask` when they are not provided.
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## Attention backends
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`sdpa` (PyTorch Scaled Dot Product Attention) is the default.
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| Backend | Key | Notes |
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| :--- | :--- | :--- |
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| PyTorch SDPA | `"sdpa"` | Default. Exact numerics, stable on all hardware. |
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| Flash Attention | `"kernels_flash"` | Fastest on Ampere/Hopper GPUs. Requires `pip install kernels` (pre-built β no hours-long compilation). Outputs are not bitwise identical to SDPA due to online softmax reordering; differences are often small but not guaranteed to be inconsequential β use `"sdpa"` if exact numerics matter. |
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| Flex Attention | `"flex"` | Skips padding tokens via block mask β faster on variable-length batches. Near-exact numerics. First use compiles a Triton kernel (30β120 s). Best combined with `torch.compile`. |
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| Auto | `"auto"` | Picks the best available: `kernels_flash` β `flex` β `sdpa`. |
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Set via config before loading, or change on the model after loading (DPLM2 propagates the change to all attention layers immediately):
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```python
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from transformers import AutoConfig, AutoModel
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# Option 1: set before loading
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config = AutoConfig.from_pretrained("Synthyra/DPLM2-150M", trust_remote_code=True)
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config.attn_backend = "flex"
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model = AutoModel.from_pretrained("Synthyra/DPLM2-150M", config=config, trust_remote_code=True)
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# Option 2: set after loading
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model = AutoModel.from_pretrained("Synthyra/DPLM2-150M", trust_remote_code=True)
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model.attn_backend = "flex" # propagates to all attention layers in-place
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```
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## Embed datasets
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All DPLM2 models inherit `EmbeddingMixin`, so you can call `model.embed_dataset(...)` directly.
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## Citations
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```bibtex
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@article{wang2024dplm2,
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title={DPLM-2: A Multimodal Diffusion Protein Language Model},
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author={Wang, Xinyou and Ye, Zaixiang and Huang, Fei and Cao, Dongyan and Liang, Shujian and Huang, Liang},
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journal={arXiv preprint arXiv:2410.13782},
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year={2024}
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}
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```
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```bibtex
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@misc{FastPLMs,
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author={Hallee, Logan and Bichara, David and Gleghorn, Jason P.},
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title={FastPLMs: Fast, efficient, protein language model inference from Huggingface AutoModel.},
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year={2024},
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url={https://huggingface.co/Synthyra/ESMplusplus_small},
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DOI={10.57967/hf/3726},
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publisher={Hugging Face}
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}
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```
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```bibtex
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@article{dong2024flexattention,
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title={Flex Attention: A Programming Model for Generating Optimized Attention Kernels},
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author={Dong, Juechu and Feng, Boyuan and Guessous, Driss and Liang, Yanbo and He, Horace},
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journal={arXiv preprint arXiv:2412.05496},
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year={2024}
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}
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```
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```bibtex
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@inproceedings{paszke2019pytorch,
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title={PyTorch: An Imperative Style, High-Performance Deep Learning Library},
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author={Paszke, Adam and Gross, Sam and Massa, Francisco and Lerer, Adam and Bradbury, James and Chanan, Gregory and Killeen, Trevor and Lin, Zeming and Gimelshein, Natalia and Antiga, Luca and Desmaison, Alban and K{\"o}pf, Andreas and Yang, Edward and DeVito, Zach and Raison, Martin and Tejani, Alykhan and Chilamkurthy, Sasank and Steiner, Benoit and Fang, Lu and Bai, Junjie and Chintala, Soumith},
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booktitle={Advances in Neural Information Processing Systems 32},
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year={2019}
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}
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```
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---
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library_name: transformers
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tags: []
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+
---
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+
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# NOTE
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The GitHub with the implementation and requirements can be found [here](https://github.com/Synthyra/FastPLMs.git).
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+
|
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+
# DPLM2
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+
Synthyra DPLM2 checkpoints are HuggingFace AutoModel compatible and include FastPLMs embedding helpers.
|
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+
|
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## Supported models
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```python
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model_dict = {
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"Synthyra/DPLM2-150M": "airkingbd/dplm2_150m",
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+
"Synthyra/DPLM2-650M": "airkingbd/dplm2_650m",
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"Synthyra/DPLM2-3B": "airkingbd/dplm2_3b",
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}
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```
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## Use with transformers
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```python
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import torch
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from transformers import AutoModel, AutoModelForMaskedLM
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+
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model_path = "Synthyra/DPLM2-150M"
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model = AutoModel.from_pretrained(model_path, trust_remote_code=True, dtype=torch.float16).eval()
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tokenizer = model.tokenizer
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+
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batch = tokenizer(["MPRTEIN", "MSEQWENCE"], padding=True, return_tensors="pt")
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with torch.no_grad():
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hidden = model(**batch).last_hidden_state
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mlm = AutoModelForMaskedLM.from_pretrained(model_path, trust_remote_code=True, dtype=torch.float16).eval()
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with torch.no_grad():
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logits = mlm(**batch).logits
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```
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+
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## DPLM2 modality types
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+
DPLM2 infers `type_ids` automatically from `input_ids` and `attention_mask` when they are not provided.
|
| 41 |
+
|
| 42 |
+
## Attention backends
|
| 43 |
+
|
| 44 |
+
`sdpa` (PyTorch Scaled Dot Product Attention) is the default.
|
| 45 |
+
|
| 46 |
+
| Backend | Key | Notes |
|
| 47 |
+
| :--- | :--- | :--- |
|
| 48 |
+
| PyTorch SDPA | `"sdpa"` | Default. Exact numerics, stable on all hardware. |
|
| 49 |
+
| Flash Attention | `"kernels_flash"` | Fastest on Ampere/Hopper GPUs. Requires `pip install kernels` (pre-built β no hours-long compilation). Outputs are not bitwise identical to SDPA due to online softmax reordering; differences are often small but not guaranteed to be inconsequential β use `"sdpa"` if exact numerics matter. |
|
| 50 |
+
| Flex Attention | `"flex"` | Skips padding tokens via block mask β faster on variable-length batches. Near-exact numerics. First use compiles a Triton kernel (30β120 s). Best combined with `torch.compile`. |
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| 51 |
+
| Auto | `"auto"` | Picks the best available: `kernels_flash` β `flex` β `sdpa`. |
|
| 52 |
+
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| 53 |
+
Set via config before loading, or change on the model after loading (DPLM2 propagates the change to all attention layers immediately):
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| 54 |
+
|
| 55 |
+
```python
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+
from transformers import AutoConfig, AutoModel
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+
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# Option 1: set before loading
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config = AutoConfig.from_pretrained("Synthyra/DPLM2-150M", trust_remote_code=True)
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config.attn_backend = "flex"
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model = AutoModel.from_pretrained("Synthyra/DPLM2-150M", config=config, trust_remote_code=True)
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# Option 2: set after loading
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model = AutoModel.from_pretrained("Synthyra/DPLM2-150M", trust_remote_code=True)
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model.attn_backend = "flex" # propagates to all attention layers in-place
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```
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+
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## Embed datasets
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All DPLM2 models inherit `EmbeddingMixin`, so you can call `model.embed_dataset(...)` directly.
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+
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+
## Citations
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+
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+
```bibtex
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+
@article{wang2024dplm2,
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+
title={DPLM-2: A Multimodal Diffusion Protein Language Model},
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| 76 |
+
author={Wang, Xinyou and Ye, Zaixiang and Huang, Fei and Cao, Dongyan and Liang, Shujian and Huang, Liang},
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journal={arXiv preprint arXiv:2410.13782},
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year={2024}
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}
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```
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+
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```bibtex
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+
@misc{FastPLMs,
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author={Hallee, Logan and Bichara, David and Gleghorn, Jason P.},
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+
title={FastPLMs: Fast, efficient, protein language model inference from Huggingface AutoModel.},
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+
year={2024},
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url={https://huggingface.co/Synthyra/ESMplusplus_small},
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DOI={10.57967/hf/3726},
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publisher={Hugging Face}
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}
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```
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+
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+
```bibtex
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+
@article{dong2024flexattention,
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+
title={Flex Attention: A Programming Model for Generating Optimized Attention Kernels},
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+
author={Dong, Juechu and Feng, Boyuan and Guessous, Driss and Liang, Yanbo and He, Horace},
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+
journal={arXiv preprint arXiv:2412.05496},
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+
year={2024}
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}
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```
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+
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```bibtex
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+
@inproceedings{paszke2019pytorch,
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+
title={PyTorch: An Imperative Style, High-Performance Deep Learning Library},
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| 105 |
+
author={Paszke, Adam and Gross, Sam and Massa, Francisco and Lerer, Adam and Bradbury, James and Chanan, Gregory and Killeen, Trevor and Lin, Zeming and Gimelshein, Natalia and Antiga, Luca and Desmaison, Alban and K{\"o}pf, Andreas and Yang, Edward and DeVito, Zach and Raison, Martin and Tejani, Alykhan and Chilamkurthy, Sasank and Steiner, Benoit and Fang, Lu and Bai, Junjie and Chintala, Soumith},
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booktitle={Advances in Neural Information Processing Systems 32},
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year={2019}
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}
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```
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