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- ---
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- license: cc-by-4.0
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- ---
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
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+ ---
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+ license: cc-by-nc-nd-4.0
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+ tags:
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+ - spatial-transcriptomics
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+ - pathology
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+ - histology
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+ - deep-learning
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+ - pytorch
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+ ---
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+
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+ # MoLF: Mixture-of-Latent-Flow for Pan-Cancer Spatial Gene Expression Prediction from Histology
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+
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+ <div align="center">
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+
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+ [![arXiv](https://img.shields.io/badge/arXiv-2601.21560-b31b1b.svg)](https://arxiv.org/abs/2602.02282)
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+ [![Model Architecture](https://img.shields.io/badge/Model-MoLF-blue)]()
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+ [![Dataset](https://img.shields.io/badge/Dataset-HEST-green)]()
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+
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+ </div>
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+ **MoLF** is a deep learning model designed to bridge the gap between histology images (H&E) and spatial gene expression.
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+ Check out the details in the [github repo](https://github.com/susuhu/MoLF).
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+ This repository contains the weights for the checkpoints in the paper trained on the HEST v1.1.0 dataset.
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+ ## 📄 Paper
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+ **Title:** MoLF: Mixture-of-Latent-Flow for Pan-Cancer Spatial Gene Expression Prediction from Histology
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+ **Authors:** Hu, Susu and Speidel, Stefanie
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+ **Link:** [ICLR 2026 arXiv](https://arxiv.org/abs/2602.02282)
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+
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+
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+ ## 💻 Usage
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+ To load this checkpoint, ensure you have the MoLF codebase or compatible model definition.
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+ ```python
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+ from huggingface_hub import hf_hub_download
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+ import torch
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+
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+ # Download the model checkpoint
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+ checkpoint_path = hf_hub_download(repo_id="HuSusu/MoLF", filename="MoLF_latent_vae.ckpt")
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+
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+ # Load weights (Pseudo-code: replace with your actual model class)
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+ # model = HistoPrism(config=...)
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+ # checkpoint = torch.load(path, map_location=map_location)
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+ # model.load_state_dict(checkpoint["model_state"])
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+