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# TD3B: Transition-Directed Discrete Diffusion for Allosteric Binder Generation
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TD3B is a sequence-based generative framework that designs peptide binders with specified agonist or antagonist behavior. It combines a Direction Oracle, a soft binding-affinity gate, and amortized fine-tuning of a pre-trained discrete diffusion model (MDLM).
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# TD3B: Transition-Directed Discrete Diffusion for Allosteric Binder Generation
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<div align="center">
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<a href="https://arxiv.org/abs/2605.09810"><img src="https://img.shields.io/badge/Arxiv-2605.09810-red?style=for-the-badge&logo=Arxiv" alt="arXiv"/></a>
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</div>
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TD3B is a sequence-based generative framework that designs peptide binders with specified agonist or antagonist behavior. It combines a Direction Oracle, a soft binding-affinity gate, and amortized fine-tuning of a pre-trained discrete diffusion model (MDLM).
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