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README.md
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---
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license: mit
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---
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license: mit
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tags:
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- medical-imaging
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- computational-pathology
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- survival-analysis
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- multimodal
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- tcga
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datasets:
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- TCGA
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library_name: pytorch
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---
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# ProtoPathway
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Pretrained checkpoints, preprocessed cohort data, and the curated pathway
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graph for **ProtoPathway**, an interpretable-by-design multimodal framework
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for cancer survival prediction.
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See the [code repository](https://github.com/AmayaGS/ProtoPathway) for usage,
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training, and evaluation instructions.
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## Layout
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```
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pathways/ shared curated Reactome + Hallmark pathways
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cohorts/{cohort}/
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gene_expression.csv preprocessed expression matrix
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bipartite_graph.pt cohort-specific gene-pathway graph
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labels.csv survival times, events, and bins
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data_splits.pkl 5-fold CV splits (SurvPath-compatible)
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checkpoints/best_fold_{0..4}.pt trained model weights
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```
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## Cohorts
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Five TCGA cohorts: BRCA (N=714), BLCA (N=359), COADREAD (N=227),
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HNSC (N=392), STAD (N=318). Gene expression is the preprocessed
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SurvPath release. WSI patch features (UNI2-h) are not redistributed
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here and should be obtained from the
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[Mahmood Lab](https://huggingface.co/MahmoodLab/UNI2-h) directly.
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## Quick load
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```python
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from huggingface_hub import snapshot_download
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# Everything for one cohort plus the shared pathway file
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snapshot_download(
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repo_id="AmayaGS/ProtoPathway",
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local_dir="./assets",
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allow_patterns=["cohorts/TCGA-BLCA/*", "pathways/*"],
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)
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```
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## Citation
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```bibtex
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@article{protopathway2026,
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title = {ProtoPathway: Interpretable Multimodal Cancer Survival Prediction
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via Prototype-Pathway Cross-Modal Attention},
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author = {...},
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year = {2026}
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}
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```
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